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Immunology

Immunology

eLife publishes research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Decisions are made by journal editors who are active researchers in the field of immunology.

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Pancreatic α and β cells have different cell autonomous signatures; this explains why α but not β cells can clear infections by potentially diabetogenic viruses.
Laura Marroqui, Miguel Lopes, Reinaldo S dos Santos, Fabio A Grieco, Merja Roivainen, Sarah J Richardson, Noel G Morgan, Anne Op de beeck, Decio L Eizirik
10.7554/eLife.06990
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A chemical biology approach has identified the kinase DYRK1A as a new regulator of the inflammatory response.
Bernard Khor, John D Gagnon, Gautam Goel, Marly I Roche, Kara L Conway, Khoa Tran, Leslie N Aldrich, Thomas B Sundberg, Alison M Paterson, Scott Mordecai, David Dombkowski, Melanie Schirmer, Pauline H Tan, Atul K Bhan, Rahul Roychoudhuri, Nicholas P Restifo, John J O'Shea, Benjamin D Medoff, Alykhan F Shamji, Stuart L Schreiber, Arlene H Sharpe, Stanley Y Shaw, Ramnik J Xavier
10.7554/eLife.05920
Interleukin 6 (IL-6) can mediate pathogenesis of autoimmune diseases through its effects on mitochondrial function.
Rui Yang, Dario Lirussi, Tina M Thornton, Dawn M Jelley-Gibbs, Sean A Diehl, Laure K Case, Muniswamy Madesh, Douglas J Taatjes, Cory Teuscher, Laura Haynes, Mercedes Rincón
10.7554/eLife.06376
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Atypical memory B cells (MBCs) appear to differentiate from classical MBCs during chronic exposure to the malaria parasite Plasmodium falciparum, and may interfere with the acquisition of immunity to the disease.
Silvia Portugal, Christopher M Tipton, Haewon Sohn, Younoussou Kone, Jing Wang, Shanping Li, Jeff Skinner, Kimmo Virtaneva, Daniel E Sturdevant, Stephen F Porcella, Ogobara K Doumbo, Safiatou Doumbo, Kassoum Kayentao, Aissata Ongoiba, Boubacar Traore, Inaki Sanz, Susan K Pierce, Peter D Crompton
10.7554/eLife.07218
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The integration of signals via the pleiotropic NF-kappaB (NF-κB) system enables microenvironmental cues to tune cellular responses to pathogenic substances.
Balaji Banoth, Budhaditya Chatterjee, Bharath Vijayaragavan, MVR Prasad, Payel Roy, Soumen Basak
10.7554/eLife.05648
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The number of different peptides presented by major histocompatibility complex class I molecules to the immune system's T lymphocytes is inversely correlated with cell surface expression and is strongly associated with the response to infectious disease.
Paul E Chappell, El Kahina Meziane, Michael Harrison, Łukasz Magiera, Clemens Hermann, Laura Mears, Antoni G Wrobel, Charlotte Durant, Lise Lotte Nielsen, Søren Buus, Nicola Ternette, William Mwangi, Colin Butter, Venugopal Nair, Trudy Ahyee, Richard Duggleby, Alejandro Madrigal, Pietro Roversi, Susan M Lea, Jim Kaufman
10.7554/eLife.05345
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By contributing to the maintenance of ROS homeostasis, CD33-related Siglecs control oxidative damage and influence rate of aging and lifespan.
Flavio Schwarz, Oliver MT Pearce, Xiaoxia Wang, Annie N Samraj, Heinz Läubli, Javier O Garcia, Hongqiao Lin, Xiaoming Fu, Andrea Garcia-Bingman, Patrick Secrest, Casey E Romanoski, Charles Heyser, Christopher K Glass, Stanley L Hazen, Nissi Varki, Ajit Varki, Pascal Gagneux
10.7554/eLife.06184

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Showing results 1 - 10 of 70