Immunology

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Autophagy is required for CD8+ T cell memory formation; in aged individuals autophagy levels are diminished, and increasing autophagy enhances their CD8+ T cell responses.
Daniel J Puleston, Hanlin Zhang, Timothy J Powell, Elina Lipina, Stuart Sims, Isabel Panse, Alexander S Watson, Vincenzo Cerundolo, Alain RM Townsend, Paul Klenerman, Anna Katharina Simon
10.7554/eLife.03706
The co-stimulatory molecule CD28 is required after T cell priming for helper T cell polarization in response to an infection.
Michelle A Linterman, Alice E Denton, Devina P Divekar, Ilona Zvetkova, Leanne Kane, Cristina Ferreira, Marc Veldhoen, Simon Clare, Gordon Dougan, Marion Espéli, Kenneth GC Smith
10.7554/eLife.03180
A novel zinc finger transcription factor regulates expression of multiple genes in late stage thymocytes and recent thymic emigrants to promote formation of the naïve T cell compartment.
Brenda Y Han, Shuang Wu, Chuan-Sheng Foo, Robert M Horton, Craig N Jenne, Susan R Watson, Belinda Whittle, Chris C Goodnow, Jason G Cyster
10.7554/eLife.03549
Activation of lung macrophage nitric oxide synthase-3 improves both bacterial clearance and outcome in primary and secondary pneumonia models.
Zhiping Yang, Yuh-Chin T Huang, Henry Koziel, Rini de Crom, Hartmut Ruetten, Paulus Wohlfart, Reimar W Thomsen, Johnny A Kahlert, Henrik Toft Sørensen, Szczepan Jozefowski, Amy Colby, Lester Kobzik
10.7554/eLife.03711
The transcription factor NFIL3 is essential for the development of a committed bone marrow precursor that gives rise to all known innate lymphoid cell lineages in mice.
Xiaofei Yu, Yuhao Wang, Mi Deng, Yun Li, Kelly A Ruhn, Cheng Cheng Zhang, Lora V Hooper
10.7554/eLife.04406

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