Immunology and Inflammation

Immunology and Inflammation

eLife reviews research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Immunology and Inflammation

    Nociceptor neurons control pollution-mediated neutrophilic asthma

    Jo-Chiao Wang, Amelia Kulle ... Sebastien Talbot
    Air pollution activates macrophage-derived artemin, sensitizing TRPA1 nociceptors to drive neutrophilic asthma, revealing new therapeutic targets for refractory airway inflammation.
    1. Immunology and Inflammation

    Beta-Glucan Modulates Monocyte Plasticity and Differentiation Capacity to Mitigate DSS-Induced Colitis

    Yinyin Lv, Yanyun Fan ... Hongzhi Xu
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Immunology and Inflammation

    During an inflammatory response, zebrafish tnfa and tnfb are expressed by different cell types and have distinct expression kinetics

    Kaylee SE van Dijk, Christina Begon-Pescia ... Maria Forlenza
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Adaptor protein supersaturation drives innate immune signaling and cell fate

    Alejandro Rodriguez Gama, Tayla Miller ... Randal Halfmann
    In-cell biophysical analyses identify a sequence-encoded energy storage function of innate immune adaptor proteins that allows cells to respond quickly and decisively to pathogenic signals.
    1. Cancer Biology
    2. Immunology and Inflammation

    The 1000+ mouse project for large-scale spatiotemporal parametrization and modeling of preclinical cancer immunotherapies

    Adam L Kenet, Sooraj Achar ... Grégoire Y Altan-Bonnet
    An automated bioluminescent image analysis framework, maRQup, parametrizes tumor dynamics and provides quantitative metrics, enabling large-scale evaluation and optimization of preclinical cancer immunotherapies.
    1. Immunology and Inflammation

    Ex vivo and in vivo CRISPR/Cas9 screenings identify the roles of protein N-glycosylation in regulating T-cell activation and functions

    Yu Hong, Xiaofang Si ... Yu Zhang
    Inactivation of beta 1,4-galactosyltransferase 1 leads to enhanced T-cell receptor activation and CD8+ T-cell function by affecting the galactosylation of T-cell receptor and CD8.
    1. Immunology and Inflammation

    A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification

    Jordan Z Zhou, Bihui Huang ... Kang Chen
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Cell Biology
    2. Immunology and Inflammation

    Clathrin-independent endocytosis and retrograde transport in cancer cells tune immune synapse organization and CD8 T cell response

    Shiqiang Xu, Alix Buridant ... Henri-François Renard
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Developmental Biology
    2. Immunology and Inflammation

    HEB collaborates with TCR signaling to upregulate Id3 and enable γδT17 cell maturation in the fetal thymus

    Johanna S Selvaratnam, Juliana Dutra Barbosa da Rocha ... Michele K Anderson
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Immunology and Inflammation

    Temporal single-cell analysis reveals age-associated delay in immune resolution after respiratory viral infection

    Yue Wu, Chaofan Li ... Jie Sun
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
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Highlights

    1. Developmental Biology
    2. Immunology and Inflammation

    A hemocyte atlas for an insect

    Samuel Liegeois, Dominique Ferrandon
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    The immune basis of disease susceptibility

    Ruy M Ribeiro, Luis Graca
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Parkinson's and innate immunity

    Rebecca L Wallings, Mary K Herrick, Malú Gámez Tansey

Senior editors

  1. Diane M Harper
    University of Michigan, United States
  2. Joshua T Schiffer
    Fred Hutchinson Cancer Research Center, United States
  3. Aleksandra Walczak
    Ecole Normale Superieure, France
  4. See more editors