Immunology

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Experiment-driven quantitative model of IL-2 secretion demonstrates how T cells integrate their digital antigen responses into an analog-scaled output.
Karen E Tkach, Debashis Barik, Guillaume Voisinne, Nicole Malandro, Matthew M Hathorn, Jesse W Cotari, Robert Vogel, Taha Merghoub, Jedd Wolchok, Oleg Krichevsky, Grégoire Altan-Bonnet
10.7554/eLife.01944
Natural killer cells that were commonly thought to circulate around the body can actually reside in distinct tissues, such as in the liver, skin or uterus, and do not re-circulate.
Dorothy K Sojka, Beatrice Plougastel-Douglas, Liping Yang, Melissa A Pak-Wittel, Maxim N Artyomov, Yulia Ivanova, Chao Zhong, Julie M Chase, Paul B Rothman, Jenny Yu, Joan K Riley, Jinfang Zhu, Zhigang Tian, Wayne M Yokoyama
10.7554/eLife.01659
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To avoid recognition by the immune system, bacteria use autolysins to trim fragments of peptidoglycans that are exposed on the bacterial cell wall.
Magda Luciana Atilano, Pedro Matos Pereira, Filipa Vaz, Maria João Catalão, Patricia Reed, Inês Ramos Grilo, Rita Gonçalves Sobral, Petros Ligoxygakis, Mariana Gomes Pinho, Sérgio Raposo Filipe
10.7554/eLife.02277
Inhibition of the catalytic activity of the Zap70 kinase reveals that discrete TCR-regulated events control the remodelling of the actin cytoskeleton when the cytotoxic T cell interacts with its target.
Misty R Jenkins, Jane C Stinchcombe, Byron B Au-Yeung, Yukako Asano, Alex T Ritter, Arthur Weiss, Gillian M Griffiths
10.7554/eLife.01310
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Both beneficial and pathogenic bacteria can use their sheathed flagella during host colonization as a novel toxin-/signal-delivery mechanism.
Caitlin A Brennan, Jason R Hunt, Natacha Kremer, Benjamin C Krasity, Michael A Apicella, Margaret J McFall-Ngai, Edward G Ruby
10.7554/eLife.01579
Mitochondrial anti-viral signaling proteins form three-stranded helical filaments in launching innate immune responses against RNA viruses.
Hui Xu, Xiaojing He, Hui Zheng, Lily J Huang, Fajian Hou, Zhiheng Yu, Michael Jason de la Cruz, Brian Borkowski, Xuewu Zhang, Zhijian J Chen, Qiu-Xing Jiang
10.7554/eLife.01489

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