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Immunology

Immunology

eLife publishes research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Decisions are made by journal editors who are active researchers in the field of immunology.

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Showing results 1 - 10 of 69
A chemical biology approach has identified the kinase DYRK1A as a new regulator of the inflammatory response.
Bernard Khor, John D Gagnon, Gautam Goel, Marly I Roche, Kara L Conway, Khoa Tran, Leslie N Aldrich, Thomas B Sundberg, Alison M Paterson, Scott Mordecai, David Dombkowski, Melanie Schirmer, Pauline H Tan, Atul K Bhan, Rahul Roychoudhuri, Nicholas P Restifo, John J O'Shea, Benjamin D Medoff, Alykhan F Shamji, Stuart L Schreiber, Arlene H Sharpe, Stanley Y Shaw, Ramnik J Xavier
10.7554/eLife.05920
Accepted manuscript
Silvia Portugal, Christopher M Tipton, Haewon Sohn, Younoussou Kone, Jing Wang, Shanping Li, Jeff Skinner, Kimmo Virtaneva, Daniel E Sturdevant, Stephen F Porcella, Ogobara K Doumbo, Safiatou Doumbo, Kassoum Kayentao, Aissata Ongoiba, Boubacar Traore, Inaki Sanz, Susan K Pierce, Peter D Crompton
10.7554/eLife.07218
The integration of signals via the pleiotropic NF-kappaB (NF-κB) system enables microenvironmental cues to tune cellular responses to pathogenic substances.
Balaji Banoth, Budhaditya Chatterjee, Bharath Vijayaragavan, MVR Prasad, Payel Roy, Soumen Basak
10.7554/eLife.05648
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The number of different peptides presented by major histocompatibility complex class I molecules to the immune system's T lymphocytes is inversely correlated with cell surface expression and is strongly associated with the response to infectious disease.
Paul E Chappell, El Kahina Meziane, Michael Harrison, Łukasz Magiera, Clemens Hermann, Laura Mears, Antoni G Wrobel, Charlotte Durant, Lise Lotte Nielsen, Søren Buus, Nicola Ternette, William Mwangi, Colin Butter, Venugopal Nair, Trudy Ahyee, Richard Duggleby, Alejandro Madrigal, Pietro Roversi, Susan M Lea, Jim Kaufman
10.7554/eLife.05345
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By contributing to the maintenance of ROS homeostasis, CD33-related Siglecs control oxidative damage and influence rate of aging and lifespan.
Flavio Schwarz, Oliver MT Pearce, Xiaoxia Wang, Annie N Samraj, Heinz Läubli, Javier O Garcia, Hongqiao Lin, Xiaoming Fu, Andrea Garcia-Bingman, Patrick Secrest, Casey E Romanoski, Charles Heyser, Christopher K Glass, Stanley L Hazen, Nissi Varki, Ajit Varki, Pascal Gagneux
10.7554/eLife.06184
The cytotoxicity exerted by CD8+ T cells against parasitized erythroblasts helps to protect against blood-stage malaria by making parasitized cells susceptible to phagocytosis.
Takashi Imai, Hidekazu Ishida, Kazutomo Suzue, Tomoyo Taniguchi, Hiroko Okada, Chikako Shimokawa, Hajime Hisaeda
10.7554/eLife.04232
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T cell receptor signaling is regulated by newly polymerized F-actin foci at the immunological synapse.
Sudha Kumari, David Depoil, Roberta Martinelli, Edward Judokusumo, Guillaume Carmona, Frank B Gertler, Lance C Kam, Christopher V Carman, Janis K Burkhardt, Darrell J Irvine, Michael L Dustin
10.7554/eLife.04953

Pages

Show10255075100rows
Showing results 1 - 10 of 69