Immunology

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Sialoside-based pattern recognition by Siglecs directly regulates toll-like receptor signaling and a sialidase inhibitor protects against endotoxemia.
Guo-Yun Chen, Nicholas K Brown, Wei Wu, Zahra Khedri, Hai Yu, Xi Chen, Diantha van de Vlekkert, Alessandra D'Azzo, Pan Zheng, Yang Liu
10.7554/eLife.04066
Serum amyloid A proteins bind retinol with nanomolar affinity, and do so by forming oligomers that create a hydrophobic pocket that shields retinol from the aqueous environment.
Mehabaw G Derebe, Clare M Zlatkov, Sureka Gattu, Kelly A Ruhn, Shipra Vaishnava, Gretchen E Diehl, John B MacMillan, Noelle S Williams, Lora V Hooper
10.7554/eLife.03206
Novel virus-host systems yield insights into how Lepidopterans (moths and butterflies) combat RNA virus infection and reveal that poxvirus A51R proteins can suppress the host's immune system and stabilize microtubules in host cells.
Don B Gammon, Sophie Duraffour, Daniel K Rozelle, Heidi Hehnly, Rita Sharma, Michael E Sparks, Cara C West, Ying Chen, James J Moresco, Graciela Andrei, John H Connor, Darryl Conte Jr., Dawn E Gundersen-Rindal, William L Marshall, John R Yates, Neal Silverman, Craig C Mello
10.7554/eLife.02910
IL-6 signaling in T cells controls how sensitive they are to suppression by T regulatory cells, and the way mature to become memory T cells.
Simone A Nish, Dominik Schenten, F Thomas Wunderlich, Scott D Pope, Yan Gao, Namiko Hoshi, Shuang Yu, Xiting Yan, Heung Kyu Lee, Lesley Pasman, Igor Brodsky, Brian Yordy, Hongyu Zhao, Jens Brüning, Ruslan Medzhitov
10.7554/eLife.01949

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