Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Targeted computational redesign of an IL-7 superkine with enhanced folding efficiency and receptor affinity demonstrates superior immune-stimulatory and antitumor activity over wild-type IL-7.
The glial-specific role of betaPix during cerebral blood vessel development has been revealed by establishing a new betaPix conditional trap allele in zebrafish.
Distinct patterns of SARS-CoV-2 viral dynamics in saliva reveal heterogeneity that cannot be sufficiently explained by conventional clinical characteristics or microRNA profiles alone.
Christos Sourmpis, Carl CH Petersen ... Guillaume Bellec
Multi area RNN models fitted to in-vivo cortical activity predict behavioral changes induced by optogenetic perturbations, if biologically informed connectivity constraints on the optogenetically targeted inhibitory neurons are applied.
A simple statistical model captures the essential features of object motion in a large database of natural scenes, helping to shed light on the challenges posed to sensory and motor systems.
BK and CaV1.3 channels interact early during biogenesis, assembling intracellularly before membrane localization, indicating coordinated processes for functional coupling.
Genetic approaches identify Rtf1-dependent transcriptional pausing as an essential mechanism governing the deployment of the cardiac gene program during myocardial differentiation from the mesoderm.
Exosome-associated THSD7A is identified as a key trigger of filopodia formation in cancer cells and neurons, revealing a novel pathway with implications for metastasis, neuronal connectivity, and other filopodia-dependent processes.
Bioinformatics, RNA-protein interactions, and HuR-based functional studies demonstrated that the rs13900T allele modulates CCL2 transcript levels, providing a functional link between the CCL2 rs1024611G-rs13900T haplotype and disease susceptibility/progression.
