Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Hidden outward-facing intermediates and long-lived ATP-bound states reveal how ATP binding drives conformational dynamics in the heterodimeric ABC transporter TmrAB.
Fangfang Hong, Ruby Bouhassira ... David H Brainard
Leveraging the smooth variation of internal noise makes comprehensive characterization of color discrimination practical, offering an efficient framework for studying perceptual limits across various sensory domains.
Hanane Hadj-Moussa, Megan Ulusan ... Jonathan Houseley
Re-engineering a highly conserved metabolic pathway in yeast prevents age-related functional decline and proves that ageing is not inevitably linked to loss of fitness.
Rachel H Clare, Adam Westhorpe ... Nicholas R Casewell
Despite the variation in venom across the Bothrops snake genus, repurposed drugs demonstrated pan-species neutralisation in enzymatic, coagulation, and haemorrhage assays, highlighting their value as novel therapies for Neotropical snakebites.
Inflammatory activation of endothelial cells triggers Pink1-dependent mitophagy and mitochondrial formyl peptides release, which drives neutrophil recruitment and lung injury.
Fundamental distinctions in the extracellular signatures of active-dendritic chemical and electrical synapses necessitate a revision of conventional interpretations of local field potentials centered on chemical synapses.
A time-dependent genetic interaction between the µ opioid receptor and genes drives early morphine responses in mice, highlighting pathways linked to human substance use disorder.
