Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Single-molecule tracking of transcription factors in living cells revealed how mutations that make short activation domains stronger increased the fraction of transcription factor molecules bound to chromatin and led to longer residence times on chromatin.
Marta Chaverra, John Paul Toney ... R Steven Stowers
Drosophila internal male reproductive organs exhibit parallel innervation by two types of multi-transmitter neurons, a subset of which are essential for fertility, and organ-specific spatially discrete neurotransmitter receptor expression.
An affinity-guided chemical strategy enabling highly specific biotinylation of P2X7 receptors reveals, by super-resolution microscopy, how the nanoscale organization of endogenous P2X7 in BV2 microglial cells dynamically changes upon activation.
Olympia Colizoli, Tessa M van Leeuwen ... Harold Bekkering
Pupil dilation provides a physiological readout of information gain during the brain's internal process of belief updating in the context of associative learning.
Sarah E Sandkuhler, Kayla S Youngs ... Samuel J Mackenzie
Evidence from multiple model systems supports a shift away from heme transport and toward metabolic dysfunction and oxidative stress as key drivers of TANGO2 deficiency.
A low-dimensional voice latent space derived from deep learning captures speaker-identity representations in the temporal voice areas and supports reconstruction of voices preserving identity information.
