Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    Acquisition of auditory discrimination mediated by different processes through two distinct circuits linked to the lateral striatum

    Susumu Setogawa, Takashi Okauchi ... Kazuto Kobayashi
    Two lateral striatal subregions integrate the acquisition of stimulus-based decision-making in spatiotemporally and functionally different manners, challenging the prior model through a dominance change from the associative to sensorimotor subregions.
    1. Neuroscience

    Ultraslow serotonin oscillations in the hippocampus delineate substates across NREM and waking

    Claire Cooper, Daniel Parthier ... Dietmar Schmitz
    The fine-tuning of mutual inhibition and disinhibition of sleep-regulating neurons and also the memory consolidation that occurs during NREM sleep are controlled by oscillations in serotonin levels.
    1. Cell Biology

    The microbiome interacts with the circadian clock and dietary composition to regulate metabolite cycling in the Drosophila gut

    Yueliang Zhang, Sara B Noya ... Amita Sehgal
    The Drosophila microbiome regulates the cycling of gut metabolites in a circadian clock and diet-dependent manner.
    1. Developmental Biology

    NR2F2 is required in the embryonic testis for fetal Leydig cell development

    Aitana Perea-Gomez, Natividad Bellido Carreras ... Marie-Christine Chaboissier
    NR2F2 regulates fetal Leydig cell differentiation and steroidogenesis in mouse testes, providing mechanistic insight into testis development and the etiology of 46,XY differences in sex development.
    1. Microbiology and Infectious Disease

    Bacteriophage infection drives loss of β-lactam resistance in methicillin-resistant Staphylococcus aureus

    My Tran, Angel J Hernandez Viera ... Charlie Y Mo
    In methicillin-resistant Staphylococcus aureus, evolution of bacteriophage resistance causes trade-offs that re-sensitize the bacteriato β-lactam antibiotics.
    1. Neuroscience

    A temporally restricted function of the dopamine receptor Dop1R2 during memory formation

    Jenifer C Kaldun, Emanuele Calia ... Simon G Sprecher
    The dopamine receptor Dop1R2 plays a crucial role in the formation of longer-lasting memories, while it is dispensable for short-term memories.
    1. Evolutionary Biology
    2. Structural Biology and Molecular Biophysics

    Prebiotic gas flow environment enables isothermal nucleic acid replication

    Philipp Schwintek, Emre Eren ... Dieter Braun
    Exponential nucleic acid replication can occur isothermally in a prebiotically plausible setting that accumulates and simultaneously separates the strands of nucleic acids through evaporation-driven flows at the gas–water interface.
    1. Microbiology and Infectious Disease

    Fast evolution of SOS-independent multi-drug resistance in bacteria

    Le Zhang, Yunpeng Guan ... Dayong Jin
    A single β-lactam exposure rapidly drives stable multidrug resistance in RecA-deficient bacteria through an SOS-independent mechanism involving oxidative stress-induced mutagenesis and antibiotic-driven selection.
    1. Stem Cells and Regenerative Medicine

    CRISPR-edited DPSCs constitutively expressing BDNF enhance dentin regeneration in injured teeth

    Ji Hyun Kim, Muhammad Irfan ... Seung Chung
    Brain-derived neurotrophic factor/tropomyosin receptor kinase B signaling in promoting the differentiation and dentin-repair capacity of dental stem cells under inflammatory conditions offers a potential clinical strategy for repairing damaged teeth.
    1. Neuroscience

    Molecular characterization of gustatory second-order neurons reveals integrative mechanisms of gustatory and metabolic information

    Rubén Mollá-Albaladejo, Manuel Jiménez-Caballero, Juan Antonio Sanchez-Alcaniz
    Leucokinin neurons integrate sweet and bitter taste inputs with starvation signals to regulate feeding initiation, balancing nutrient intake against the risk of toxin ingestion.