Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    Phase-specific premotor inhibition modulates leech rhythmic motor output

    Martina Radice, Agustin Sanchez Merlinsky ... Lidia Szczupak
    Premotor nonspiking neurons regulate the level of motor activity through a recurrent inhibitory circuit.
    1. Cell Biology
    2. Genetics and Genomics

    Cross-species evaluation of TANGO2 homologs, including HRG-9 and HRG-10 in Caenorhabditis elegans, challenges a proposed role in heme trafficking

    Sarah E Sandkuhler, Kayla S Youngs ... Samuel J Mackenzie
    Evidence from multiple model systems supports a shift away from heme transport and toward metabolic dysfunction and oxidative stress as key drivers of TANGO2 deficiency.
    1. Computational and Systems Biology
    2. Neuroscience

    Reconstructing voice identity from noninvasive auditory cortex recordings

    Charly Lamothe, Etienne Thoret ... Pascal Belin
    A low-dimensional voice latent space derived from deep learning captures speaker-identity representations in the temporal voice areas and supports reconstruction of voices preserving identity information.
    1. Neuroscience

    Barcode activity in a recurrent network model of the hippocampus enables efficient memory binding

    Ching Fang, Jack W Lindsey ... Selmaan N Chettih
    The representation of individual memories in a recurrent neural network can be efficiently differentiated using chaotic recurrent dynamics.
    1. Neuroscience

    Dissecting surveying behavior of reactive microglia under chronic neurodegeneration

    Sunitha Subhramanian, Olga Bocharova ... Ilia V Baskakov
    In chronic neurodegeneration associated with prion disease, reactive microglia adopt a highly mobile, neuron-by-neuron surveillance strategy, replacing homeostatic process-based monitoring with dynamic somatic migration and prolonged neuronal engagement.
    1. Neuroscience

    Pupil dilation offers a time-window on prediction error

    Olympia Colizoli, Tessa M van Leeuwen ... Harold Bekkering
    Pupil dilation provides a physiological readout of information gain during the brain's internal process of belief updating in the context of associative learning.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Atypical collective oscillatory activity in cardiac tissue uncovered by optogenetics

    Alexander S Teplenin, Nina N Kudryashova ... Tim De Coster
    Collective frequency-selective resonance in depolarised cardiac tissue enables reversible switching between quiescent and ectopic oscillations through hidden bi-stability, which is shaped by light intensity, illuminated area, and pacing frequency.
    1. Cancer Biology
    2. Genetics and Genomics

    Replication stress-inducing ELF3 upregulation promotes BRCA1-deficient breast tumorigenesis in luminal progenitors

    Jiadong Zhou, Xiao Albert Zhou ... Jiadong Wang
    A replication stress–ELF3 axis enables luminal progenitor transformation in BRCA1-deficient breast cancer by reducing genomic instability and promoting progenitor identity.
    1. Cancer Biology

    Identification of a Musashi2 translocation as a novel oncogene in myeloid leukemia

    Kyle Spinler, Michael Hamilton ... Tannishtha Reya
    A naturally occurring Musashi2 genetic translocation reported to occur in blast crisis chronic myelogenous leukemia patients can act as an oncogene and drive myeloid leukemia.
    1. Plant Biology

    Rice stripe virus utilizes a Laodelphax striatellus salivary carbonic anhydrase to facilitate plant infection by direct molecular interaction

    Jing Zhao, Xiangyi Meng ... Lili Zhang
    Planthopper salivary carbonic anhydrase enhances a plant β-1,3-glucanase to suppress callose deposition, facilitating early viral establishment of rice stripe virus.