Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
A system to enrich yeast in metaphase of mitosis, meiosis I, or meiosis II reveals reduced spindle assembly checkpoint robustness in meiosis I and distinct kinetochore composition and phosphorylation states.
Detecting replay during longer time periods (e.g. resting state or sleep) with temporally delayed linear modeling (TDLM) requires biologically implausible event densities, and purely synthetic simulations substantially overestimate the method's sensitivity.
The phase of cortical activity, measured in the gray matter, is organized at multiple spatial scales, with the largest scales explaining most variance in phase at a given temporal frequency.
Direct survival benefits in larger groups rather than kin-selected indirect fitness primarily drive the evolution of division of labor in cooperatively breeding vertebrates, particularly under harsh environmental conditions.
Elucidation of the Hox code defining forelimb positioning provides novel insights into lateral plate mesoderm patterning and the integration of vertebrate column structure and limb positioning.
Analysis of scRNA-seq data from primate embryoid bodies highlights the value of cross-species comparisons for identifying and characterizing cell types, as marker genes can evolve fast.
Structural characterization of the CTLH-CRA domain-mediated pairing in the CTLH ubiquitin ligase complex enables rational engineering of interfaces with altered binding specificity.
Frederick A Matsen IV, Will Dumm ... Hugh K Haddox
Factoring out nucleotide-level mutation biases from antibody language models dramatically improves prediction of functional mutation effects while reducing computational cost by orders of magnitude.
Genomic neighborhood signatures delineate catalytic versus putative regulatory CODH clades, establishing a framework for predicting enzyme functionality and guiding discovery of biocatalysts for CO2 reduction.
