Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Pascale Pescher, Thibaut Douché ... Gerald F Späth
Integrated multi-omics profiling provides evidence for coordinated changes across RNA turnover, translation, phosphorylation, and protein degradation during Leishmania differentiation, generating candidate therapeutic targets for leishmaniasis.
Simultaneous EEG–fMRI recordings in 107 human participants link coupled slow oscillations and sleep spindles to thalamic coordination of hippocampal–prefrontal communication during deep sleep.
Population-level analysis of dendritic spine nanostructure identifies distinct synaptic signatures of schizophrenia and autism, revealing Ecrg4 as a regulator of schizophrenia-associated spine pathology.
Corey T Callaghan, Diana E Bowler ... Thomas Merckx
Across the tree of life, urban communities are consistently characterized by many urban-avoiding species and few urban exploiters, revealing a general pattern in biodiversity responses to urbanization.
Bordetella pertussis hijacks the host innate immune protein PGLYRP1 via tracheal cytotoxin to suppress inflammation and evade killing, revealing a novel immune evasion strategy.
Vasileios Ioakeimidis, Marco Palombo ... Claudia Metzler-Baddeley
Novel SANDI diffusion modelling reveals Huntington’s disease-related striatal abnormalities in proxy soma measures, explaining atrophy and motor impairment, and supporting SANDI indices as in vivo biomarkers of human neurodegenerative processes.
Stefan Zdraljevic, Laura Walter-McNeill ... Leonid Kruglyak
A maternal toxin-antidote element has degenerated into an antidote-only remnant in some Caenorhabditis elegans isolates, while in others, the toxin may instead be silenced by small RNAs.
The pathogenicity of MECP2 C-terminal deletions is determined by translational reading frame, enabling prediction of clinical outcome and a shared therapeutic genome editing strategy.
