Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Three newly developed biosensors demonstrate that the C-terminal tail of α-tubulin does not freely extend from the microtubule surface as widely thought, but rather is inaccessible along most microtubules in cells.
Harrison A Grier, Sohrab Salimian, Matthew T Kaufman
Mouse primary motor and somatosensory cortices contain detailed information about the many time-varying arm and paw joint angles during reaching and grasping, implying a 'low-level' role in controlling these movements.
Drug repurposing analyses show that citalopram exerts anti-tumor effects by targeting C5aR1 on tumor-associated macrophages to enhance phagocytosis and CD8+ T cell immunity.
Philémon Roussel, Mingyi Zhou ... Auguste Genovesio
Metabolic imaging of the Drosophila mushroom body reveals distinct profiles among Kenyon cell subtypes and detects a subtle learning-associated metabolic change.
Muscle stem cells repurpose the tenogenic factor Scx to establish a muscle-specific transcriptional program that sustains stem cell expansion, migration, differentiation, fusion, self-renewal, and survival.
Upregulated expression of transcription factors promoting cone identity in late-stage retinal progenitors drives development of the cone-dominant retina of 13-lined ground squirrels.
Small-molecule mitochondrial transcription factor A modulators stabilize mtDNA, preventing cytosolic escape and suppressing cGAS-STING interferon signaling, while improving bioenergetics and fibrosis markers in disease models.
A multidisciplinary approach demonstrates that glycolysis orchestrates fungal morphogenesis and virulence by regulating the de novo biosynthesis of sulfur-containing amino acids, thereby establishing a novel metabolic paradigm.
Mir195 enables Ebf1-deficient hematopoietic progenitor cells to mature into B cells, suggesting some miRNA can substitute for transcription factors in differentiation.
The IL-17–Ly6G⁺ granulocyte axis is a key driver and correlate of tuberculosis pathology and represents a potential target for improving vaccine-induced protection and therapeutic outcomes.
