Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Cargo-adaptor binding to the KLC-TPR domains binding triggers structural rearrangements that relieve kinesin-1 autoinhibition, enabling MAP7 recruitment, through an allosteric mechanism that connects cargo recognition to motor activation.
Synaptotagmin 1 and Synaptotagmin 7 promote MAIT cell activation during Mycobacterium tuberculosis infection by facilitating MR1 trafficking and antigen presentation.
Shwetha Srinivasan, Xingcheng Lin ... Gabriela S Schlau-Cohen
Membrane composition modulates EGFR conformational dynamics and signaling, revealing that the bilayer properties can override ligand control to influence receptor activation in health and disease.
Geometric confinement paradoxically enhances bacterial chemotaxis through chiral surface swimming and sidewall alignment, with optimal performance when lane width matches the circular swimming radius.
Ken-ichiro F Kamei, Koseki J Kobayashi-Kirschvink ... Yuichi Wakamoto
Conservation levels of gene expression abundance ratios are globally coordinated in cells, and cellular state changes under such biologically relevant stoichiometric constraints are readable as low-dimensional changes in Raman spectra.
Olfactory fear conditioning biases olfactory stem cell receptor fate, increasing the frequency by which maturing neurons express the receptor of the paired odor and changing the representation of the olfactory sensory neuron landscape in the next generation.
Brett A Hathaway, Dexter R Kim ... Catharine Winstanley
Sensory cues increase risky choice when paired with wins but reduce risky choice when paired with losses, with parallel shifts in sensitivity to negative outcomes.
Maryam Karimian, Mark Jonathan Roberts ... Mario Senden
Principles of weakly coupled oscillators capture human figure-ground segregation and its training-induced enhancement, indicating gamma synchrony remains a plausible grouping mechanism.
