Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
A boundary between the sensory and nonsensory domains contains cells that undergo a series of morphological changes and form basal constriction to separate the segregating inner ear sensory organs.
Fitness constraints on the HIV envelope protein are highly similar in humans and rhesus macaques, emphasizing the utility of macaque models of infection and antibody development.
Eye-specific differences in presynaptic release site addition and clustering correlate with axonal segregation outcomes during retinogeniculate refinement in the mouse.
Spatially and temporally overlapping target and distractor are both rhythmically sampled at ~1 Hz, and the phase relationship between target sampling and distractor sampling predicts behavior.
Single-molecule imaging uncovers how distinct membrane-binding motifs and the intrinsically disordered C-terminal domain control RNase E’s membrane association and diffusion, linking structural divergence to RNA-processing dynamics in bacteria.
Yaeram Jeong, Chung-ha O Davis ... Nicholas Marsh-Armstrong
Increased transfer of axonal mitochondria to optic nerve astrocytes after expression of glaucoma-associated Optineurin variants suggest that increased transcellular degradation of axonal mitochondria may play a causative role in at least some forms of glaucoma.
Ultrasound localization microscopy in awake mice enables high-resolution imaging of cerebral microvasculature in a natural physiological state, eliminates confounding effects of anesthetics, and supports reliable longitudinal vascular assessment across weeks.
