Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Ji Zhou, Muhammad Sarmad Sajid ... Manuel A Castro-Alamancos
Cautious action timing under threat depends on glutamatergic signaling from the subthalamic nucleus to the midbrain, revealing a circuit mechanism for adaptive goal-directed behavior.
Miguel Barretto-Garcia, Marcus Grueschow ... Christian C Ruff
Disrupting left superior frontal sulcus selectively impaired perceptual but not value-based decisions, revealing segregated prefrontal circuits for integrating sensory evidence versus subjective preferences in human choice behaviour.
Facial emotion representations expand from sensory cortex to prefrontal regions across development, suggesting that the prefrontal cortex matures with development to enable a full understanding of facial emotion.
The carboxyl-terminal alanine-threonine-tailed protein ATP5α helps glioblastoma mitochondria maintain a high membrane potential and keep the permeability transition pore closed, thereby promoting tumor growth and increasing resistance to apoptosis.
Centralized migration accelerates adaptation and drives parallel evolution, emphasizing the key influence of spatial organization on evolutionary dynamics across systems from pathogen transmission to species range shifts.
Profiling cell-specific immune responses reveals altered neutrophil function and enhanced T-cell mediated cell death following acute in vivo exposure to tobacco-flavored e-cigarette aerosol using single-cell technology.
Fluid flow analysis reveals that both swimming and sessile ciliates achieve competitive nutrient uptake, resolving the long-standing debate over the hydrodynamic advantage of either strategy.
Intrinsic conformational flexibility of a solute transporter is restrained by substrates, resulting in Na+ allosterically enhancing primary substrate binding through cooperative constraints on the dynamics of the cytoplasmic inner barrier.
A novel F-actin-binding motif consisting of an α-helix hairpin from a Legionella pneumophila lysine fatty acyltransferase has the potential to be developed as an F-actin probe.
