Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    Recovery of the full in vivo firing range in post-lesion surviving DA SN neurons associated with Kv4.3-mediated pacemaker plasticity

    Lora Kovacheva, Josef Shin ... Jochen Roeper
    Dopamine midbrain neurons surviving a lesion slowly recover their in vivo firing patterns by homeostatic pacemaker acceleration mediated by Kv4.3 channel downregulation.
    1. Computational and Systems Biology
    2. Neuroscience

    Correlation detection as a stimulus computable account for audiovisual perception, causal inference, and saliency maps in mammals

    Cesare V Parise
    Optimal cue integration, Bayesian Causal Inference, spatial orienting, speech illusions and other key phenomena in audiovisual perception naturally emerge from the collective behavior of a population of Multisensory Correlation Detector.
    1. Medicine

    Cell-autonomous and non-cell-autonomous effects of Arginase 2 on cardiac aging

    Duilio M Potenza, Xin Cheng ... Xiu-Fen Ming
    Arginase 2 in macrophages promotes cardiac aging phenotype via paracrine release of IL-1β.
    1. Neuroscience

    Characterization of postsynaptic glutamate transporter functionality in the zebrafish retinal first synapse across different wavelengths

    Marco Garbelli, Stephanie Niklaus, Stephan CF Neuhauss
    Loss of the glutamate transporters EAAT5b and EAAT7 disrupts wavelength-specific visual processing and UV-dependent prey detection in zebrafish, revealing their key roles in modulating light integration and behaviorally relevant vision.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Short heat shock factor A2 regulates heat resistance and growth balance in Arabidopsis

    Wanxia Chen, Jiaqi Zhao ... Xiaoting Qi
    Short heat shock factor variants prevent hyperactivation of thermotolerance through a noncanonical heat shock response, thereby balancing heat stress response and plant growth.
    1. Biochemistry and Chemical Biology

    Insight into the bioactivity and action mode of betulin, a candidate aphicide from plant metabolite, against aphids

    Junxiu Wang, Matthana Klakong ... Hong Zhou
    The insecticidal activity of betulin, a plant-derived metabolite, against the peach aphid depends on specific targeting and inhibition of MpGABR.
    1. Cell Biology
    2. Developmental Biology

    Glucose-stimulated KIF5B-driven microtubule sliding organizes microtubule networks in mouse pancreatic β cells

    Kai M Bracey, Margret A Fye ... Irina Kaverina
    Sub-membrane microtubule array, known to prevent excessive glucose-stimulated insulin secretion, depends on kinesin-1 KIF5B, which moves microtubules to both generate and remodel this array, potentially regulating the dosage of secretion.
    1. Neuroscience

    Relative timescale of channel voltage dependence and channel density regulation impacts assembly and recovery of activity

    Yugarshi Mondal, Ronald L Calabrese, Eve Marder
    Ion channel voltage-dependence alterations can shape intrinsic homeostatic plasticity, even if operating faster than other intrinsic regulatory processes—where timescale separation would suggest its influence should be negligible.
    1. Biochemistry and Chemical Biology

    Engineering NIR-sighted bacteria

    Stefanie SM Meier, Michael Hörzing ... Andreas Möglich
    Custom-tailored bathy-phytochromes control bacterial gene expression by near-infrared light while exhibiting minimal response to red light, thus unlocking innovative application scenarios.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Characterization of binding kinetics and intracellular signaling of new psychoactive substances targeting cannabinoid receptor using transition-based reweighting method

    Soumajit Dutta, Diwakar Shukla
    New psychoactive substances activate cannabinoid receptors using distinct ligand-receptor interactions.