Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
A combination of three transcriptional regulators (CEBPB, NFE2L2, and BCL3) can shift macrophages from an M1 to an M2 phenotype, altering their susceptibility to bacterial infection.
The glycolipid MPIase acts as a receptor of twin-arginine translocation (TAT) signals, inserts them into membranes, and potentially modulates the TatABC structure to facilitate TAT translocation.
Infectious disease resistance in chickens strongly depends on a genomic region called the MHC, and the rules governing pathogen peptide presentation for a key MHC molecule may aid vaccine development.
Yi Lueningschroer-Wang, Emilia Derksen ... Christian Wegener
Wall-following and total walking activity in a behavioural assay can serve as indicators of emotional valence and arousal and provide evidence for the presence of emotion primitives in fruit flies.
The choice of fitness metric is crucial in microbial ecology—commonly chosen metrics lead to different results that may affect the conclusions from pairwise competition assays and high-throughput genetic screens.
Morgane Vandendoren, Jason G Landen ... Adam Nelson
Oxytocin neurons couple physiological warming to behavioral arousal, revealing a homeostatic mechanism that coordinates transitions between low- and high-energy states.
Simulation-based inference predicts putative circuit mechanisms of hyperexcitability in a phenomenological microcircuit simulator with more than 30 free intrinsic and synaptic parameters.
The interaction of important signaling pathway members identified through in silico and in vitro approaches provides a model that suggests local receptor multimerization through bridging functions of various ligands.
A large-scale convergence gradient and a fine-scale divergence gradient in cortical architecture capture visual hierarchy, areal boundaries, and behavior, uncovering an undescribed retinotopic representation in anterior temporal cortex.
