Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    Dissociable roles of reward prediction error in the contrasting mood dynamics of depression and anxiety

    Zhihao Wang, Ting Wang ... Pengfei Xu
    Depression-specific symptoms blunt mood responses to unexpected outcomes, whereas anxiety-specific symptoms amplify them in non-clinical participants, with depression-related blunting also replicated in patients with affective disorders.
    1. Neuroscience

    PKD2L1 channels segregated to the apical compartment are the dual-mode pH sensor in cerebrospinal fluid-contacting neurons

    Magdalena Vitar, Daniel Prieto ... Federico F Trigo
    Apical PKD2L1 channels generate phasic and sustained currents that together make spinal cerebrospinal fluid-contacting neurons exquisite pH sensors.
    1. Computational and Systems Biology
    2. Developmental Biology

    Single-cell spatial mapping reveals reproducible cell type organization and spatially dependent gene expression in gastruloids

    Catherine Triandafillou, Pranav Sompalle ... Arjun Raj
    Detailed, single-cell spatial gene expression across multiple gastruloids highlights macro-scale organizational consistency, simultaneous with variance in meso-scale patterning.
    1. Cell Biology
    2. Neuroscience

    Tau hyperphosphorylation impairs cooperative binding to microtubules and perturbs organelle trafficking in neurons

    Daniel Beaudet, Christopher L Berger, Adam G Hendricks
    Single-molecule motility assays and live-cell imaging in neurons reveal that tau hyperphosphorylation disrupts the formation of cooperative tau envelopes along microtubules and lysosomal transport.
    1. Structural Biology and Molecular Biophysics

    Bifunctional architecture enables substrate catalysis and channeling in Paracoccus TMAO demethylase

    Trung Thach, KanagaVijayan Dhanabalan ... Ramaswamy Subramanian
    Trimethylamine N-oxide demethylase uses substrate channeling to couple trimethylamine N-oxide demethylation with one-carbon metabolism, safely detoxifying formaldehyde while enhancing metabolic efficiency.
    1. Structural Biology and Molecular Biophysics

    Two Glu/Asp residues cooperatively mediate an early step of ATP hydrolysis in GHKL ATPases MutL and GyrB

    Kenji Fukui, Ayaka Shibuya ... Takato Yano
    A cooperative catalytic mechanism provides a revised framework for understanding ATP hydrolysis in a broad subset of GHKL ATPases.
    1. Neuroscience

    Retinal curl as a functional signal for heading estimation beyond the focus of expansion

    Kontessa I Zorpala, Joan López-Moliner
    The rotational retinal flow generated by natural gaze stabilization is not merely visual noise to be subtracted but actively shapes human heading perception.
    1. Neuroscience

    Developmental synchrony of retinal waves, apoptosis, and angiogenesis in postnatal retina

    Michael A Savage, Cori Bertram ... Evelyne Sernagor
    An interdisciplinary approach uncovers a never-before-seen multifaceted synchrony of developmental processes in the rodent retina which are driven by purinergic signalling from apoptotic retinal ganglion cells.
    1. Developmental Biology

    Cellular basis of accelerated whole-tooth regeneration

    Talha Mubeen, Haowen He ... Jeffrey T Streelman
    Tooth plucking triggers a rapid, coordinated regeneration program in cichlids, accelerating replacement more than threefold through temporally organized epithelial, mesenchymal, immune, vascular, and neural signaling.
    1. Biochemistry and Chemical Biology

    Integrated respirometry and metabolomics unveil circadian metabolic dynamics in Drosophila

    Farheen Akhtar, Dania M Malik ... Aalim Weljie
    Wild-type flies anticipate daily respiratory demands by coordinating substrate use, whereas short-sleep and clock-deficient mutants shift toward reactive fuel use and altered redox metabolism.
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