Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Continuous noisy learning in neural networks leads to slow, directed qualitative changes in their internal representations, without affecting their quality.
Marco van den Noort, Panagiotis Drougkas ... Bert Poolman
Transient and weak interactions between the substrate-binding proteins of the ATP-binding cassette transporter OpuA can influence the transport efficiency.
Rita De Gasperi, Laszlo Csernoch ... Christopher P Cardozo
Genetic reduction of Numb or Numb/Nubl is linked to deterioration of the Septin cytoskeleton and suggests cytoskeletal abnormalities are the consequences of and contribute to age-related changes in skeletal muscle.
The N-terminal domain of Staphylococcus aureus GpsB, a scaffolding protein, forms an atypical asymmetric dimer and binds to the C-termini of FtsZ and PBP4, influencing the localization and regulation of both the Z-ring and cell wall synthesis.
Diversified genetic and transcriptional changes in parallel evolved Escherichia coli populations for improved growth revealed that the evolution complementing genome reduction was like all roads leading to Rome.
Genome-wide PARP-1 binding analysis advances the understanding of molecular mechanisms governing gene regulation in response to developmental cues and environmental stressors.
Local abnormal fungi in Caesarean section scar diverticulum can affect the abundance of bacteria through specific metabolites, thereby destroying the stability of bacteria and the entire microbial community.
Timothy J Walker, Eduardo Reyes-Alvarez ... Lois M Mulligan
TMEM127 depletion alters membrane dynamics, promoting cell surface accumulation and constitutive activity of growth factor receptors, and ultimately providing a novel paradigm for oncogenesis through aberrant receptor localization and signaling.
