Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    Dependence of contextual modulation in macaque V1 on interlaminar signal flow

    Shude Zhu, Yu Jin Oh ... Tirin Moore
    Interactions between neurons across cortical layers reflect the balance of feedforward and feedback inputs.
    1. Plant Biology

    Rice stripe virus utilizes a Laodelphax striatellus salivary carbonic anhydrase to facilitate plant infection by direct molecular interaction

    Jing Zhao, Xiangyi Meng ... Lili Zhang
    Planthopper salivary carbonic anhydrase enhances a plant β-1,3-glucanase to suppress callose deposition, facilitating early viral establishment of rice stripe virus.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Decoding the biogenesis of HIV-induced CPSF6 puncta and their fusion with nuclear speckles

    Chiara Tomasini, Celine Cuche ... Francesca Di Nunzio
    HIV hijacks SRRM2 to enlarge nuclear speckles, stabilizing CPSF6 puncta and promoting efficient viral replication.
    1. Neuroscience

    Neural coding of multiple motion speeds in visual cortical area MT

    Xin Huang, Bikalpa Ghimire ... Steven Wiesner
    Neuronal responses in cortical area MT to two speeds show a robust bias toward the faster speed when stimulus speeds are slow, which could benefit figure-ground segregation in natural scenes.
    1. Microbiology and Infectious Disease

    Heterogeneity of genetic sequence within quasi-species of influenza virus revealed by single-molecule sequencing

    Kenji Tamao, Hiroyuki Noji, Kazuhito Tabata
    High-accuracy single-molecule unique molecular identifier sequencing reveals non-random, biologically driven mutation heterogeneity within influenza quasi-species, enabling precise profiling of intra-host viral evolutionary potential.
    1. Cell Biology

    CCDC32 stabilizes clathrin-coated pits and drives their invagination

    Ziyan Yang, Changsong Yang ... Zhiming Chen
    Live cell imaging and biochemical analyses reveal that CCDC32 interacts with AP2 to stabilize and drive invagination of clathrin-coated pits, and that clinical mutations disrupting this interaction cause cardio-facio-neuro-developmental syndrome.
    1. Ecology

    Female moths incorporate plant acoustic emissions into their oviposition decision-making process

    Rya Seltzer, Guy Zer Eshel ... Yossi Yovel
    Acoustic ecology introduces an additional dimension in plant-insect communication, revealing that female moths use ultrasonic emissions from dehydrated plants to guide oviposition decisions.
    1. Neuroscience

    Population analyses reveal heterogenous encoding in the medial prefrontal cortex during naturalistic foraging

    Ji Hoon Jeong, June-Seek Choi
    During foraging under predatory threat, overlapping prefrontal neuron populations flexibly switch between encoding navigational space and predicting avoidance decisions.
    1. Neuroscience

    Differential destinations, dynamics, and functions of high- and low-order features in the feedback signal during object processing

    Wenhao Hou, Sheng He, Jiedong Zhang
    Feedback signals to the early visual cortex convey both high-order and low-order visual information, but with different laminar profiles, and the high-order information is important for object recognition.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Deletion of the moeA gene in Flavobacterium IR1 drives structural color shift from green to blue and alters polysaccharide metabolism

    Álvaro Escobar Doncel, Constantinos Patinios ... Colin J Ingham
    Disrupting a single molybdenum cofactor gene allowed us to connect metabolic regulation of complex carbohydrates with cell organization, enabling genetic tuning of bacterial structural color for biomaterial applications.