Karla J Suchacki, Benjamin J Thomas ... William P Cawthorn
The health benefits of caloric restriction, including decreasing body fat and blood glucose, differ between males and females and this difference depends on the age at which caloric restriction begins.
Mice with a mutation that disrupts the release of growth hormone show greatly increased lifespan, which can be further increased by caloric restriction.
Bone marrow adipocyte lipolysis is required for maintaining bone mass under conditions of energy deficiency and is necessary for myelopoiesis following caloric restriction and irradiation.
The use of forward genetic screens in zebrafish identifies a new model of vertebrate aging, defining the regulating of the onset of aging phenotypes through maintenance of progenitor cell populations.
Marie Francois, Isabella Canal Delgado ... Lori Zeltser
Systematic testing of experimental variables in a common neurobehavioral paradigm revealed that conditions that more closely match human physiology reliably elicit stress eating in mice.
Activation of mu-opioid receptors in the nucleus accumbens by their endogenous ligands promotes consumption of high-fat food in sated but not hungry rats, via enhancement of a neural signal that promotes cued approach behavior.