Biochemistry

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How nuclear pore complexes establish their permeability barrier has been a long-standing question; now, this process can be reconstituted by a surprisingly simple and rapid self-assembly of Nup98 FG domains into selective FG phases.
Hermann Broder Schmidt, Dirk Görlich
10.7554/eLife.04251
Building on previous work (Ly et al., 2014), we show that elutriated cells and arrested cells have similar patterns of DNA content and cyclin expression: however, a large fraction of the proteome changes detected in arrested cells are found to reflect arrest-specific responses rather than physiological cell cycle regulation.
Tony Ly, Aki Endo, Angus I Lamond
10.7554/eLife.04534
Selective docking of HAC1 mRNA on Ire1 clusters at a site separate from the Ire1 RNase domain is key for endoplasmic reticulum stress signaling.
Eelco van Anken, David Pincus, Scott Coyle, Tomás Aragón, Christof Osman, Federica Lari, Silvia Gómez Puerta, Alexei V Korennykh, Peter Walter
10.7554/eLife.05031
Two membrane proteins that belong to a new type of cell-surface receptor mediate the transmembrane signaling for a secreted factor that has broad therapeutic value.
Guo Cheng, Ming Zhong, Riki Kawaguchi, Miki Kassai, Muayyad Al-Ubaidi, Jun Deng, Mariam Ter-Stepanian, Hui Sun
10.7554/eLife.05401
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Cytosolic and organellar Hsp90s from higher eukaryotes have evolved a variable, and environmentally responsive N-terminal extension to regulate their activity.
James R Partridge, Laura A Lavery, Daniel Elnatan, Nariman Naber, Roger Cooke, David A Agard
10.7554/eLife.03487
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