Biochemistry

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Interactions between Aim24 and the mitochondrial outer and inner membrane contact site complex (MICOS) are essential for mitochondrial ultrastructure, lipid composition and oxidative phosphorylation.
Max Emanuel Harner, Ann-Katrin Unger, Toshiaki Izawa, Dirk M Walther, Cagakan Özbalci, Stefan Geimer, Fulvio Reggiori, Britta Brügger, Matthias Mann, Benedikt Westermann, Walter Neupert
10.7554/eLife.01684
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Phosphorylation of the Wnt receptor LRP6 directly inhibits glycogen synthase kinase-3 by acting as a pseudosubstrate that stabilizes an active conformation of the enzyme, identical to autoinhibition by phosphorylation of its N terminus.
Jennifer L Stamos, Matthew Ling-Hon Chu, Michael D Enos, Niket Shah, William I Weis
10.7554/eLife.01998
The mechanism of inhibition by unfair competition is central to determining the protein phosphorylation states that govern cell cycle transitions between M phase and interphase.
Byron C Williams, Joshua J Filter, Kristina A Blake-Hodek, Brian E Wadzinski, Nicholas J Fuda, David Shalloway, Michael L Goldberg
10.7554/eLife.01695
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Quantitative analysis of protein and mRNA expression across a minimally perturbed cell cycle in human myeloid cells has identified myeloid-specific and cell cycle-regulated gene expression, including examples of isoform- and phosphorylation-specific regulation, with all data made available in a searchable, online database.
Tony Ly, Yasmeen Ahmad, Adam Shlien, Dominique Soroka, Allie Mills, Michael J Emanuele, Michael R Stratton, Angus I Lamond
10.7554/eLife.01630
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