Biochemistry

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Comprehensive structural and compositional characterization of the in vivo 30S ribosomal assembly landscape reveals parallel pathways for 3′-domain formation and a previously unknown role for the assembly factor RimP.
Dipali G Sashital, Candacia A Greeman, Dmitry Lyumkis, Clinton S Potter, Bridget Carragher, James R Williamson
10.7554/eLife.04491
Reconstructing ancestral enzymes has revealed that a switch in kinase substrate preference evolved via an expanded specificity intermediate that is tolerated in vivo, thus providing a path for kinase diversification.
Conor J Howard, Victor Hanson-Smith, Kristopher J Kennedy, Chad J Miller, Hua Jane Lou, Alexander D Johnson, Benjamin E Turk, Liam J Holt
10.7554/eLife.04126

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