Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Dietary sulfur amino acid restriction elicits a cold-like transcriptional response in inguinal but not epididymal white adipose tissue of male mice

    Philip MM Ruppert, Aylin S Güller ... Jan-Wilhelm Kornfeld
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology

    Stall force measurement of the kinesin-3 motor KIF1A using a programmable DNA origami nanospring

    Nobumichi Takamatsu, Hiroko Furumoto ... Kumiko Hayashi
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology

    An aphid-resistant plant metabolite as a candidate aphicide: Insight into the bioactivity and action mode of betulin against aphids

    Junxiu Wang, Matthana Klakong ... Hong Zhou
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Pleomorphic effects of three small-molecule inhibitors on transcription elongation by Mycobacterium tuberculosis RNA polymerase

    Omar Herrera-Asmat, Alexander B Tong ... Carlos Bustamante
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Squidly: Enzyme Catalytic Residue Prediction Harnessing a Biology-Informed Contrastive Learning Framework

    William JF Rieger, Mikael Boden ... Ariane Mora
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites

    Steven P Maher, Malina A Bakowski ... Dennis E Kyle
    Drug repurposing screens reveal several epigenetic inhibitors as active against P. vivax hypnozoites demonstrating that epigenetic pathways play a central role in hypnozoite quiescence.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    MORC2 Mediates Transcriptional Regulation Through Liquid-Liquid Phase Separation and DNA Binding

    Yanshen Zhang, Weiya Xu ... Yihui Bi
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Synthetic gene circuits that selectively target RAS-driven cancers

    Gabriel Senn, Leon Nissen, Yaakov Benenson
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology

    Brown Adipose Tissue and Skeletal Muscle Coordinately Contribute to Thermogenesis in Mice

    Yuna Izumi-Mishima, Rie Tsutsumi ... Hiroshi Sakaue
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    The glycoprotein quality control factor Malectin promotes coronavirus replication and viral protein biogenesis

    Jonathan P Davies, Lars Plate
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
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Highlights

    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

    Submit to our latest special issue in systems genetics

    1. Biochemistry and Chemical Biology

    A molecular dual carriageway

    William J Allen, Ian Collinson

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Qiang Cui
    Boston University, United States
  3. Volker Dötsch
    Goethe University, Germany
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