Biochemistry

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‘Optical tweezers’ measurements of single ribosomes and single mRNA molecules show that the translation rate depends exponentially on the applied force, and suggests that the ribosome functions as a Brownian ratchet.
Tingting Liu, Ariel Kaplan, Lisa Alexander, Shannon Yan, Jin-Der Wen, Laura Lancaster, Charles E Wickersham, Kurt Fredrik, Harry Noller, Ignacio Tinoco, Carlos J Bustamante
10.7554/eLife.03406
Studies of the substrate selectivity of concentrative nucleoside transporters provide proof of principle for structure-based improvement of drug delivery by these transporters.
Zachary Lee Johnson, Jun-Ho Lee, Kiyoun Lee, Minhee Lee, Do-Yeon Kwon, Jiyong Hong, Seok-Yong Lee
10.7554/eLife.03604
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