Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology

    Phenylhydrazone-based endoplasmic reticulum proteostasis regulator compounds with enhanced biological activity

    Gabriel M Kline, Lisa Boinon ... R Luke Wiseman
    Establishment of AA263 analogs with improved potential for correcting pathologic disruptions of endoplasmic reticulum proteostasis implicated in the onset and pathogenesis of etiologically diverse diseases.
    1. Biochemistry and Chemical Biology

    Stall force measurement of the kinesin-3 motor KIF1A using a programmable DNA origami nanospring

    Nobumichi Takamatsu, Hiroko Furumoto ... Kumiko Hayashi
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology

    Purified Zymogens Reveal Mechanisms of Snake Venom Metalloproteinase Auto-Activation

    Sophie Hall, Iara Aimê Cardoso ... Christiane Schaffitzel
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Shifting the PPARγ conformational ensemble toward a transcriptionally repressive state improves covalent inhibitor efficacy

    Liudmyla Arifova, Brian S MacTavish ... Douglas J Kojetin
    Covalent PPARγ inhibitors that better stabilize a repressive conformation are more effective inhibitors, but structural plasticity still allows ligand cobinding by enabling a shift back to an active conformation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Effects of residue substitutions on the cellular abundance of proteins

    Thea K Schulze, Kresten Lindorff-Larsen
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology

    The interplay between biomolecular assembly and phase separation

    Giacomo Bartolucci, Ivar S Haugerud ... Christoph A Weber
    Biomolecular assembly typically promotes phase separation while the presence of coexisting phases alters assembly kinetics.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Affinity-guided labeling reveals P2X7 nanoscale membrane redistribution during BV2 microglial activation

    Benoit Arnould, Adeline Martz ... Thomas Grutter
    An affinity-guided chemical strategy enabling highly specific biotinylation of P2X7 receptors reveals, by super-resolution microscopy, how the nanoscale organization of endogenous P2X7 in BV2 microglial cells dynamically changes upon activation.
    1. Biochemistry and Chemical Biology

    Differential Regulation of Hepatic Macrophage Fate by Chi3l1 in MASLD

    Jia He, Bo Chen ... Zhao Shan
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Superoxide Dismutases maintain niche homeostasis in stem cell populations

    Olivia Majhi, Aishwarya Chhatre ... Devanjan Sinha
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Convincing
    • Inadequate
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Investigating the native functions of [NiFe]-carbon monoxide dehydrogenases through genomic context analysis

    Maximilian Böhm, Henrik Land
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
Load more

Highlights

    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

    Submit to our latest special issue in systems genetics

    1. Biochemistry and Chemical Biology

    A molecular dual carriageway

    William J Allen, Ian Collinson

Senior editors

  1. Qiang Cui
    Boston University, United States
  2. David Ron
    Cambridge University, United Kingdom
  3. Kenton J Swartz
    National Institute of Neurological Disorders and Stroke, NIH, United States
  4. See more editors