Biochemistry

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The Polycomb group protein SCML2 contributes to the assembly and gene silencing function of Polycomb Repressive Complex 1 (PRC1) and requires an RNA-binding region to reach chromatin targets.
Roberto Bonasio, Emilio Lecona, Varun Narendra, Philipp Voigt, Fabio Parisi, Yuval Kluger, Danny Reinberg
10.7554/eLife.02637
The identification of four acidic amino acids as potential calcium-binding residues in the TMEM16A calcium-activated chloride channel furthers the molecular understanding of this ion channel family.
Jason Tien, Christian J Peters, Xiu Ming Wong, Tong Cheng, Yuh Nung Jan, Lily Yeh Jan, Huanghe Yang
10.7554/eLife.02772
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Genome neighborhood networks provide an efficient large-scale approach to mine metabolic pathway context for entire families of proteins and enzymes.
Suwen Zhao, Ayano Sakai, Xinshuai Zhang, Matthew W Vetting, Ritesh Kumar, Brandan Hillerich, Brian San Francisco, Jose Solbiati, Adam Steves, Shoshana Brown, Eyal Akiva, Alan Barber, Ronald D Seidel, Patricia C Babbitt, Steven C Almo, John A Gerlt, Matthew P Jacobson
10.7554/eLife.03275
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