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Biochemistry

Biochemistry


The eLife journal publishes research in the field of Biochemistry, from chemical biology and enzymology to metabolism and membrane proteins. eLife is a unique, non-profit, researcher-driven initiative. Editorial decisions are made exclusively by working scientists in your field.


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A rationally designed small molecule ATP-mimetic activates IRE1 and PERK signaling in cells by inducing conformational changes that template the assembly of higher-order enzymatically active structures.
Aaron S Mendez, Jennifer Alfaro, Marisol A Morales-Soto, Arvin C Dar, Emma McCullagh, Katja Gotthardt, Han Li, Diego Acosta-Alvear, Carmela Sidrauski, Alexei V Korennykh, Sebastian Bernales, Kevan M Shokat, Peter Walter
10.7554/eLife.05434
Structural analysis of the kinesin-13 MCAK bound to its C-terminal tail reveals the molecular basis for the conformation of kinesin-13 in solution and the mechanism that triggers long-range conformational changes upon microtubule binding.
Sandeep K Talapatra, Bethany Harker, Julie PI Welburn
10.7554/eLife.06421
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TRIM23 plays a critical role in the switching from early to late adipogenic enhanceosomes by stabilizing the PPARγ protein.
Masashi Watanabe, Hidehisa Takahashi, Yasushi Saeki, Takashi Ozaki, Shihori Itoh, Masanobu Suzuki, Wataru Mizushima, Keiji Tanaka, Shigetsugu Hatakeyama
10.7554/eLife.05615
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Showing results 1 - 10 of 210