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Biochemistry

Biochemistry

eLife publishes research spanning chemical biology and enzymology to metabolism and membrane proteins. Decisions are made by journal editors who are active researchers in biochemistry.


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CLR01 is a small molecule that could be an effective topical microbicide to eliminate HIV (and other enveloped viruses), and to antagonize host-encoded amyloid fibrils that promote HIV infection.
Edina Lump, Laura M Castellano, Christoph Meier, Janine Seeliger, Nelli Erwin, Benjamin Sperlich, Christina M Stürzel, Shariq Usmani, Rebecca M Hammond, Jens von Einem, Gisa Gerold, Florian Kreppel, Kenny Bravo-Rodriguez, Thomas Pietschmann, Veronica M Holmes, David Palesch, Onofrio Zirafi, Drew Weissman, Andrea Sowislok, Burkhard Wettig, Christian Heid, Frank Kirchhoff, Tanja Weil, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan, Elsa Sanchez-Garcia, Roland Winter, James Shorter, Jan Münch
10.7554/eLife.05397
Building on previous work (Muir et al., 2014), we validate the utility of a screen for new protein kinase substrates and define the underlying molecular basis of a new mechanism for responding to hypertonic conditions.
Alexander Muir, Françoise M Roelants, Garrett Timmons, Kristin L Leskoske, Jeremy Thorner
10.7554/eLife.09336
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