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Biochemistry

Biochemistry

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The chaperone protein BiP forms complexes with Ire1 and Perk that dissociate when unfolded proteins bind to BiP to activate the unfolded protein response in the ER.
Marta Carrara, Filippo Prischi, Piotr R Nowak, Megan C Kopp, Maruf MU Ali
10.7554/eLife.03522
A cluster of cofilin along an otherwise bare actin filament induces distinctively asymmetric cooperative conformational changes to the filament on either side of the cluster.
Kien Xuan Ngo, Noriyuki Kodera, Eisaku Katayama, Toshio Ando, Taro QP Uyeda
10.7554/eLife.04806
Most of the mRNAs whose translation is resistant to the stress-induced repression of protein synthesis contain upstream open reading frames that are efficiently translated under normal conditions.
Dmitry E Andreev, Patrick BF O'Connor, Ciara Fahey, Elaine M Kenny, Ilya M Terenin, Sergey E Dmitriev, Paul Cormican, Derek W Morris, Ivan N Shatsky, Pavel V Baranov
10.7554/eLife.03971
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