Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Genetics and Genomics

   Genome-wide structural variant landscape following HDR-enhanced CRISPR editing in human hematopoietic stem and progenitor cells

   Fanny-Meï Cloarec-Ung, Guy Sauvageau ... David JHF Knapp
2. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Metabolically Activated Proteostasis Regulators Reduce Differentiation of CD4⁺ T_H17 Cells

   Priyadarshini Chatterjee, Keishla Sánchez Ortiz ... R Luke Wiseman
3. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Molidustat targets a synthetic lethal vulnerability in APC-mutant colorectal cancer through GSTP1 and PHD2 co-inhibition

   Chiara Asselborn, Agata N Makar ... Alex von Kriegsheim

   Simultaneous loss of GSTP1 and PHD2 activity is synthetically lethal in APC-mutant colorectal cells, driving cell-cycle arrest, metabolic collapse, and apoptosis.
4. 1. Biochemistry and Chemical Biology
   2. Developmental Biology

   NAD boosting mediated by CD38 inhibition drives reversal of a pathological vicious cycle of intracrine activity and inflammation in eyelid meibomian gland dysfunction

   Yuki Hamada, Takehide Sakamoto ... Masao Doi
5. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Kinesin-1 holoenzyme assembly coordinates cargo-adaptor recognition with heavy-chain autoinhibition

   Jingling Niu, Mengmeng Zhang ... Chao Wang
6. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in colorectal cancer

   Qian Wang, Liping Li ... Chuo Chen

   Catalytic inhibition of tankyrase induces tankyrase accumulation and rigidifies the β-catenin destruction complex, limiting its ability to suppress WNT signaling.
7. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

   Sarah M Chang, Muhammad Bin Munim ... Matthew G Vander Heiden

   Examining the metabolic response of cancer cells to nutrient depletion reveals how the cell NAD+/NADH ratio can determine what nutrient environments are compatible with cancer cell proliferation.
8. 1. Biochemistry and Chemical Biology

   Inhibiting the interaction between the mitochondrial receptor Tom70 and SARS CoV 2 Orf9b with small molecules

   CJ San Felipe, Kliment A Verba ... James S Fraser
9. 1. Biochemistry and Chemical Biology

   Glycolipid MPIase is essential for the TAT (twin-arginine translocation) pathway

   Hanako Nishikawa, Nachi Yamamoto ... Ken-ichi Nishiyama

   The glycolipid MPIase acts as a receptor of twin-arginine translocation (TAT) signals, inserts them into membranes, and potentially modulates the TatABC structure to facilitate TAT translocation.
10. 1. Biochemistry and Chemical Biology

    Lateral opening site of human oligopeptide transporter 2 plays a key role in the interaction with polymyxins

    Xukai Jiang, Yining Luo ... Jian Li

    Mapping the molecular interactions between polymyxins and hPepT2 enables rational design of safer lipopeptide antibiotics with reduced renal toxicity while retaining antibacterial activity.