Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Two-way Dispatched function in Sonic hedgehog shedding and transfer to high-density lipoproteins

    Kristina Ehring, Sophia Friederike Ehlers ... Kay Grobe
    A composite hedgehog release model that incorporates and supports a previously disparate set of observations has been presented.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Point of View: Teaching troubleshooting skills to graduate students

    Gina Partipilo, Yang Gao ... Benjamin K Keitz
    Pipettes and Problem Solving is an initiative that teaches some of the skills needed to figure out why an experiment is producing unexpected results.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Structure and evolution of alanine/serine decarboxylases and the engineering of theanine production

    Hao Wang, Biying Zhu ... Zhaoliang Zhang
    Comparative structural analysis and biochemical characterization unraveled the mechanisms behind enzymatic substrate selectivity, leading to an amplified theanine yield through active mutant protein screening, thus refining strategies for theanine production.
    1. Biochemistry and Chemical Biology

    Prominin 1 and Tweety Homology 1 both induce extracellular vesicle formation

    Tristan A Bell, Bridget E Luce ... Luke H Chao
    Prominin 1 and Tweety Homology 1, two proteins that regulate membrane shape in neural and neuroepithelial cells, have shared evolutionary history and both cause cells to secrete extracellular vesicles.
    1. Biochemistry and Chemical Biology

    Syntaxin-6 delays prion protein fibril formation and prolongs the presence of toxic aggregation intermediates

    Daljit Sangar, Elizabeth Hill ... Jan Bieschke
    A new native prion protein aggregation assay shows that syntaxin-6, a risk factor for sporadic Creutzfeldt–Jakob disease, delays prion protein fibril formation and prolongs the presence of toxic aggregation intermediates.