Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Saloni Goyal, Divya Rajendran ... Athi N Naganathan
Polyphosphate, a universal stress response regulator, binds distinctively to different starting ensembles of the same protein leading to either condensates or aggregates that in turn can solubilize or further aggregate, showcasing their ability to finely control the assembly process.
Customized AlphaFold-based modeling of distinct functional states of the hERG channel, a major drug anti-target, significantly improves drug affinity predictions, enhancing cardiac safety screening for arrhythmia risk.
Joseph M Barnby, Jen Nguyen ... London Personality and Mood Disorders Consortium
Individuals with borderline personality disorder maintain rigid, distinct self-other representations, disrupting the bidirectional generalisation that underpins adaptive social learning and interpersonal trust.
Claire Cooper, Daniel Parthier ... Dietmar Schmitz
The fine-tuning of mutual inhibition and disinhibition of sleep-regulating neurons and also the memory consolidation that occurs during NREM sleep are controlled by oscillations in serotonin levels.
Two lateral striatal subregions integrate the acquisition of stimulus-based decision-making in spatiotemporally and functionally different manners, challenging the prior model through a dominance change from the associative to sensorimotor subregions.
NR2F2 regulates fetal Leydig cell differentiation and steroidogenesis in mouse testes, providing mechanistic insight into testis development and the etiology of 46,XY differences in sex development.
In methicillin-resistant Staphylococcus aureus, evolution of bacteriophage resistance causes trade-offs that re-sensitize the bacteriato β-lactam antibiotics.
