Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Computational and Systems Biology

    A neuromorphic model of active vision shows how spatiotemporal encoding in lobula neurons can aid pattern recognition in bees

    HaDi MaBouDi, Mark Roper ... James AR Marshall
    Active vision dynamically refines spatiotemporal neural representations, optimising visual processing through scanning behaviour and non-associative learning, providing insights into efficient sensory encoding in dynamic environments.
    1. Developmental Biology

    Cardiac fibroblasts regulate myocardium and coronary vasculature development in the murine heart via the collagen signaling pathway

    Yiting Deng, Yuanhang He ... Guang Li
    Cardiac fibroblasts play a critical role throughout the various phases of murine heart development ranging from the embryonic to the neonatal stage.
    1. Immunology and Inflammation

    CD131 contributes to ulcerative colitis pathogenesis by promoting macrophage infiltration

    Zhiyuan Wu, Lindi Liu ... Xiaodong Tan
    CD131 contributes to intestinal inflammation in ulcerative colitis, possibly by promoting the infiltration of macrophages, while targeting CD131 might potentially be a treatment remedy for ulcerative colitis.
    1. Biochemistry and Chemical Biology

    Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediate

    Prateeka Borar, Tapan Biswas ... Smarajit Polley
    Autocatalytic dual specificity of kinase IKK2/β, a Serine/Threonine kinase, is important for its substrate phosphorylation activity through an uncommon phosphorelay mechanism.
    1. Neuroscience

    Sex chromosome gene expression associated with vocal learning following hormonal manipulation in female zebra finches

    Matthew Davenport, Ha Na Choe ... Erich Jarvis
    Hormonal manipulation, laser microdissection, and bulk RNA sequencing indicate that Z chromosome dosage in the brain region HVC during development regulates the subsequent sexually dimorphic transcriptional specialization of zebra finch song nuclei.
    1. Structural Biology and Molecular Biophysics

    Expanding automated multiconformer ligand modeling to macrocycles and fragments

    Jessica Flowers, Nathaniel Echols ... Stephanie A Wankowicz
    qFit-ligand is a computational algorithm that enables accurate modeling of multiple conformational states of ligands in X-ray crystallography and cryo-electron microscopy (cryo-EM).
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice

    Laura Sophie Kremer, Guanbin Gao ... Nils-Göran Larsson
    Regulation of mitochondrial DNA copy number is highly tissue-specific and context-dependent, particularly in the presence of disease.
    1. Neuroscience

    Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues

    Adam Glaser, Jayaram Chandrashekar ... Karel Svoboda
    Large-scale microscopy combined with tissue clearing and expansion enables nanoscale imaging of centimeter scale specimens.
    1. Neuroscience

    Effects of experiencing the COVID-19 pandemic on optimistically biased belief updating

    Iraj Khalid, Orphee Morlaas ... Liane Schmidt
    Exposure to a real-life adversity, such as the COVID-19 pandemic, reduced the optimism bias typically observed in belief updating about future life events, shifting behavior toward more rational, Bayesian-like learning.
    1. Computational and Systems Biology

    Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism

    David Dierks, Ran Shachar ... Schraga Schwartz
    A quantitative model explains intra- and intercellular changes in m6A gene methylation as passive consequences of mRNA metabolism.