Customized AlphaFold-based modeling of distinct functional states of the hERG channel, a major drug anti-target, significantly improves drug affinity predictions, enhancing cardiac safety screening for arrhythmia risk.
Saloni Goyal, Divya Rajendran ... Athi N Naganathan
Polyphosphate, a universal stress response regulator, binds distinctively to different starting ensembles of the same protein leading to either condensates or aggregates that in turn can solubilize or further aggregate, showcasing their ability to finely control the assembly process.
Joseph M Barnby, Jen Nguyen ... London Personality and Mood Disorders Consortium
Individuals with borderline personality disorder maintain rigid, distinct self-other representations, disrupting the bidirectional generalisation that underpins adaptive social learning and interpersonal trust.
Humans can appropriately use relationships among pieces of sensory evidence (pairwise correlations) to inform decisions, rather than relying only on the physical features of individual evidence samples.
