Browse our latest research

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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Distinct mechanisms of inhibition of Kv2 potassium channels by tetraethylammonium and RY785

    Shan Zhang, Robyn Stix ... José D Faraldo-Gómez
    Computer simulations reveal the structural basis for a selective mechanism of ion-channel inhibition that could guide future pharmacological developments against associated human health disorders.
    1. Neuroscience

    AFD thermosensory neurons mediate tactile-dependent locomotion modulation in C. elegans

    Manuel Rosero, Jihong Bai
    The thermosensory neuron AFD unexpectedly modulates locomotion based on tactile experience through molecular and circuit mechanisms distinct from those underlying thermosensation.
    1. Immunology and Inflammation

    B cell expression of an enzymatic intermediary in ether lipid biosynthesis promotes antibody responses and germinal center size

    Sung Hoon Cho, Marissa A Jones ... Mark R Boothby
    Genetic experiments combined with cellular and biochemical analyses including lipidomics performed by imaging mass spectrometry reveal that the capacity of mature B lymphocytes and germinal center B cells to synthesize some ether phospholipids is vital for normal humoral responses.
    1. Neuroscience

    A Context-Free Model of Savings in Motor Learning

    Mahdiyar Shahbazi, Olivier Codol ... Paul L Gribble
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Medial prefrontal cortex encodes but is not required to generate goal-directed actions under threat

    Muhammad S Sajid, Ji Zhou, Manuel A Castro-Alamancos
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Ecology

    Wetness modulates the effects of grazing on net ecosystem productivity in global grasslands

    Yueqiang Wu, Le Qi ... Biao Zhu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Genetics and Genomics
    2. Neuroscience

    Oxytocin receptor controls promiscuity and development in prairie voles

    Ruchira Sharma, Kristen M Berendzen ... Devanand S Manoli
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    Olfactory combinatorial coding supports risk-reward decision making in C. elegans

    Md Zubayer Hossain Saad, William G Ryan ... Bruce A Bamber
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Dissociable after-effects of prosocial acts: Effort is costly for others but valued for self

    Ya Zheng, Rumeng Tang
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Cell Biology

    Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus

    Qiwang Xiang, Camille Wouters ... Jiou Wang
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid