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    1. Neuroscience

    Robust and replicable effects of ageing on resting-state brain electrophysiology measured with MEG

    Andrew J Quinn, Jemma Pitt ... Mark W Woolrich
    Resting-state MEG reveals a replicable, full-frequency profile of ageing that offers a foundation for comparing and validating brain health biomarkers although detecting specific effects requires careful consideration of statistical power.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Product-stabilized filamentation by human glutamine synthetase allosterically tunes metabolic activity

    Eric Greene, Richard Muniz ... James S Fraser
    Glutamine drives its own synthetase to assemble into inhibitory filaments, linking product concentration directly to a conformational switch that gates the active site.
    1. Neuroscience

    Synaptic connectome of a neurosecretory network in the Drosophila brain

    Theresa H McKim, Jayati Gera ... Meet Zandawala
    Connectome-level analysis of the Drosophila neuroendocrine system reveals the organizational logic by which the brain integrates sensory information to regulate hormonal signaling.
    1. Developmental Biology

    Svep1 orchestrates distal airway patterning and alveolar differentiation in murine lung development

    Nicole Foxworth, Julie Wells ... Maria Loscertales
    Genetic and functional analyses identify SVEP1 as an extracellular matrix regulator that coordinates airway branching, smooth muscle differentiation, and alveolar maturation during lung development.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Zebrafish Rif1 impacts zygotic genome activation, replication timing, and sex determination

    Emily A Masser, Tyler D Noble ... Christopher L Sansam
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Gene function and expression profiling in yeast spores, killifish diapause embryos, and their post-dormant offspring cells

    Shaimaa Hassan, Maria Rodriguez-López ... Jürg Bähler
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structures of LolB bound to LolA or lipoprotein resolve the final steps of bacterial lipoprotein trafficking

    Abigail E Jepson, Elise Kaplan ... Vassilis Koronakis
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Sequence adaptations satisfy the constraints of mitochondrial membrane protein evolution

    Tarun Yadav, Jonathan H Borowsky ... Jared Rutter
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology
    2. Cancer Biology

    P95-HER2 promotes metastatic progression by biasing MRTFA dependent signaling

    Joseph D Fernandes, Erin Bresnahan ... Joshua C Snyder
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Whole brain mapping of spinal-projecting neurons in larval zebrafish

    Martin Carbo-Tano, Kevin Fidelin ... Claire Wyart
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
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