Vikash Verma, Patricia Wadsworth, Thomas J Maresca
TIRF imaging of CRISPR-edited human cells shows dynein–dynactin complexes move processively with motility parameters consistent with the presence of multi-dynein assemblies (>one dynein heavy chain dimer per dynactin) in cells.
Independent experimental approaches demonstrate changes in TFAM binding to UVC-irradiated DNA, providing a potential mechanism for DNA damage sensing in the mitochondria.
A DNA origami nanospring introduces a force-sensing technology that enables measurement of motor protein stall forces without optical trapping, detecting force changes in kinesin KIF1A and its disease-related mutants.
Marilina Raices, Fabiola Balmir ... Judith L Yanowitz
HIM-5 emerges as a central scaffold that coordinates SPO-11 accessory complexes to control different aspects of meiotic DNA double-strand breaks, ensuring robust crossover formation on autosomes and the X chromosome.
Uev1A and APC/C degrade CycA to counteract oncogenic Ras, thereby protecting against cell death in polyploid Drosophila nurse cells and suppressing overgrowth in diploid germline and human colorectal tumor cells.
