Browse our latest research

Page 2 of 1,855
    1. Neuroscience

    Experience shapes the transformation of olfactory representations along the cortico-hippocampal pathway

    Eleonore Schiltz, Martijn Broux ... Haesler Sebastian
    The representation of stimulus identity and experience is transformed from primary olfactory cortex to memory-related multisensory areas in the hippocampus.
    Version of Record
    Short Report
    • Important
    • Solid
    1. Evolutionary Biology

    Experimental evolution to thermal stress indicates climate resilience in a cosmopolitan arthropod

    Gaoke Lei, Huiling Zhou ... Shijun You
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Developmental Synchrony of Retinal Waves, Apoptosis, and Angiogenesis in Postnatal Retina

    Michael A Savage, Cori Bertram ... Evelyne Sernagor
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Developmental Biology
    2. Neuroscience

    Complementary vertebrate Wac models exhibit phenotypes relevant to DeSanto-Shinawi Syndrome

    Kang-Han Lee, April M Stafford ... Daniel Vogt
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Brain-wide arousal signals are segregated from movement planning in the superior colliculus of the macaque

    Richard Johnston, Matthew A Smith
    Arousal signals are present in the superior colliculus but appear to be organized in a way that they avoid directly triggering motor plans that lead to saccades.
    1. Microbiology and Infectious Disease

    A macroevolution-inspired approach to reveal novel antibiotic resistance mechanisms

    Fernanda T Subtil, Teresa FG Machado ... Luiz Pedro S de Carvalho
    Using macroevolution, species not strains, uncovered important diversity in how mycobacteria respond to and resist antibiotics, revealing novel resistance determinants.
    1. Chromosomes and Gene Expression

    Uncoupling the TFIIH Core and Kinase Modules leads to misregulated RNA polymerase II CTD Serine 5 phosphorylation

    Gabriela Giordano, Robin Buratowski ... Stephen Buratowski
    The TFIIH subunit Tfb3/MAT1 can be split into two parts to uncouple the TFIIH kinase and DNA translocase modules, resulting in unfocused C-terminal domain phosphorylation.
    1. Genetics and Genomics
    2. Neuroscience

    Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling

    Kasturi Biswas, Caroline Moore ... Michael M Francis
    Muscarinic cholinergic signaling links neural activity to organism‑wide transcriptional and proteostatic responses that protect against chronic oxidative stress.
    1. Neuroscience

    A comprehensive mechanosensory connectome reveals a somatotopically organized neural circuit architecture controlling stimulus-aimed grooming of the Drosophila head

    Steven A Calle-Schuler, Alexis Santana-Cruz ... Andrew M Seeds
    A synaptic-resolution map reveals how spatially organized touch pathways in the fly brain shape aimed head grooming through parallel excitatory circuits and inhibitory control.
    1. Structural Biology and Molecular Biophysics

    Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity

    Jordan M Mancl, Wenguang G Liang ... Wei-Jen Tang
    Integrative structural analysis identifies the structural basis and key residues responsible for IDE conformational dynamics that control the unfolding and selective degradation of amyloid peptides.