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    1. Medicine

    Navigating the Path: Advice to Physician-Scientists on Choosing a Clinical Specialty

    Talia H Swartz, José E Cavazos ... Christopher S Williams
    Revised
    Reviewed Preprint v2
    Updated
    1. Developmental Biology
    2. Computational and Systems Biology

    Single-cell spatial mapping reveals reproducible cell type organization and spatially-dependent gene expression in gastruloids

    Catherine G Triandafillou, Pranav Sompalle ... Arjun Raj
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    α/β-Hydrolase domain-containing 6 (ABHD6) accelerates the desensitization and deactivation of TARP γ-2-containing AMPA receptors

    Rixu Cong, Huiran Li ... Chen Zhang
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Developmental Biology

    The NTR/prodrug revolution: Tools for controlling cell loss and regeneration

    Gha-Hyun J Kim, Michael Parsons
    Improved nitroreductase variants, optimized prodrugs, and careful experimental design enable scalable, precise cell ablation across model systems for disease modeling, regeneration studies, and high-throughput discovery.
    1. Neuroscience

    Growth in early infancy drives optimal brain functional connectivity which predicts cognitive flexibility in later childhood

    Chiara Bulgarelli, Anna Blasi ... The BRIGHT Study Team
    In Gambian infants, positive growth from 0 to 5 months of age predicted more mature brain networks, which in turn predicted cognitive outcomes at 3-5 years.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    A genetic toolkit for stable episomal transgenesis in the anaerobic gut parasite Blastocystis ST7-B

    M Rey Toleco, Kevin SW Tan, Mark van der Giezen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Compelling
    1. Genetics and Genomics

    Autosomal Allelic Inactivation: Variable Replication and Dosage Sensitivity

    Michael B Heskett, Athanasios E Vouzas ... Mathew J Thayer
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Ribosomal RNA methylation by GidB modulates discrimination of mischarged tRNA

    Zhuo Bi, Yu-Xiang Chen ... Babak Javid
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Experimental verification of the error minimization theory using non-standard genetic codes constructed in vitro

    Ryota Miyachi, Norikazu Ichihashi
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Boosting Hyperalignment Performance with Age-specific Templates

    Yuqi Zhang, Maria Ida Gobbini ... Ma Feilong
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
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