A hierarchical framework integrating artificial intelligence with chemical principles enables the conversion of fragile α-helices into ultrastable protein scaffolds.
Dysregulated exocytosis of bis(monoacylglycerol)phosphate (BMP)-enriched extracellular vesicles driven by pathogenic LRRK2 activity supports elevated urinary BMP levels and its use as a biomarker for Parkinson's disease.
Peptidoglycan recycling is essential for proper cell growth and intrinsic ampicillin resistance in Caulobacter crescentus, highlighting PG recycling enzymes as potential antibacterial targets.
