Browse our latest research

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    1. Immunology and Inflammation

    Metabolic support of trained immune responses in myeloid cells

    Aitor Jarit-Cabanillas, Gillian Dunphy ... David Sancho
    A review of literature regarding trained immunity (TI) differentiates two distinct stages of metabolic immune regulation, with primary metabolic changes influencing early epigenetic adaptations that drive TI induction and secondary metabolic adaptations providing building blocks required for enhanced immune function.
    1. Neuroscience

    Tunable Bessel beam two-photon fluorescence microscopy for high-speed volumetric imaging of brain dynamics

    Mengyang Jacky Li, Jinghui Wang ... Tian-Ming Fu
    Tunable Bessel beam two-photon fluorescence microscopy enables high-speed volumetric intravital imaging of subcellular dynamics within living mouse brains with fully tunable spatial resolution and volume coverage, allowing flexible sampling and measurements of vascular, neuronal, and immune dynamics.
    1. Neuroscience

    Multi-timescale neural adaptation underlying long-term musculoskeletal reorganization

    Roland Philipp, Yuki Hara ... Kazuhiko Seki
    Long-term motor recovery after musculoskeletal alteration relies on gradually developing novel compensatory movements to overcome the rigid, maladaptive timing of stable muscle synergies.
    1. Immunology and Inflammation
    2. Neuroscience

    Cribriform Plate Microenvironment Assembles a Suppressive Myeloid Network during EAE-induced Neuroinflammation

    Collin Laaker, Martin Hsu ... Zsuzsanna Fabry
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    Celldetective: an AI-enhanced image analysis tool for unraveling dynamic cell interactions

    Rémy Torro, Beatriz Díaz-Bello ... Laurent Limozin
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology

    Sex-biased expression of enteroendocrine cell-derived hormones contributes to higher fat storage in Drosophila females

    Puja Biswas, Elizabeth J Rideout
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Immunology and Inflammation

    Simplifying principles that underlie the highly complex peptide motif of the promiscuous chicken class I molecule, BF2*21:01

    Michael Harrison, Paul E Chappell ... Jim Kaufman
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Synaptotagmin isoforms differentially regulate glutamate and GABA release in the lateral habenula

    Dustin N White, J Keenan Kushner ... Michael HB Stowell
    Not revised
    Reviewed Preprint v1
    • Useful
    • Inadequate
    1. Neuroscience

    Fragile polyQ assemblies cause Golgipathy in Huntington’s disease

    Lixiang Ma, Xinyu Chen ... Hexige Saiyin
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Microbiology and Infectious Disease

    Virus specific impacts on honey bee flight performance are mediated by the octopamine pathway

    Naomi G Kaku, Michelle L Flenniken
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete