Browse our latest research

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    1. Cancer Biology
    2. Evolutionary Biology

    Punctuated mutagenesis promotes multi-step evolutionary adaptation in human cancers

    Christopher Graser, Wenbo Wu ... Franziska Michor
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Neuroscience

    Fitting bifurcation structure, not voltage traces: A biophysically inspired derivation of reduced neuron models exemplified by potassium dynamics

    Louisiane Lemaire, Mahraz Behbood ... Susanne Schreiber
    Not revised
    Reviewed Preprint v1
    • Useful
    • Convincing
    1. Chromosomes and Gene Expression

    Genome organization by SATB1 binding to base-unpairing regions (BURs) provides a scaffold for SATB1-regulated gene expression

    Yoshinori Kohwi, Xianrong Wong ... Terumi Kohwi-Shigematsu
    Modified ChIP-seq and 4C-seq approaches, using urea-purified crosslinked chromatin, uncovered a two-tiered chromatin organization mediated by SATB1 that is linked to gene expression.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility

    Shivraj M Yabaji, Vadim Zhernovkov ... Igor Kramnik
    Myc dysregulation in activated macrophages impairs antioxidant defenses, locking them in a vicious cycle that amplifies type I interferon signaling, driving hyperinflammation and immunosuppression.
    1. Neuroscience

    Age-related changes in ‘cortical’ 1/f dynamics are linked to cardiac activity

    Fabian Schmidt, Sarah K Danböck ... Nathan Weisz
    Age-related differences in cortical aperiodic signals can be driven by cardiac influences, emphasizing the need to control for cardiac contributions in studies interpreting cortically measured aperiodic dynamics.
    1. Immunology and Inflammation

    Trained immunity in skin infections: Macrophages and beyond

    Vitka Gres, Merve Göcer ... Philipp Henneke
    Review of the emerging understanding of trained immunity in the skin and how infection-driven cellular processes induce long-lasting immune adaptation and modulate skin barrier integrity.
    1. Neuroscience

    Balancing safety and efficiency in human decision-making

    Pranav Mahajan, Shuangyi Tong ... Ben Seymour
    A separate fear system, flexibly gated by outcome uncertainty, guides decision-making to be both safe and efficient during exploration.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Understanding the global rise of artemisinin resistance: Insights from over 100,000 Plasmodium falciparum samples

    Andrew J Balmer, Nina FD White ... Cristina Ariani
    Spatiotemporal analysis of global kelch13 surveillance data reveals that artemisinin resistance is increasing in East Africa, mirroring patterns previously observed in Southeast Asia.
    1. Cell Biology
    2. Neuroscience

    Endophilin A1 facilitates organization of the GABAergic postsynaptic machinery to maintain excitation-inhibition balance

    Xue Chen, Deng Pan ... Yanrui Yang
    Endophilin A1 at postsynaptic sites promotes inhibitory postsynaptic organization through interaction with gephyrin to maintain E/I balance, which is essential for the suppression of epilepsy susceptibility.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Tracking maternal proteins uncovers a central role for the residual body in organelle recycling during Toxoplasma gondii replication

    Julia von Knoerzer-Suckow, Parnian Sazegar ... Markus Meissner
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete