Browse our latest research

Page 2 of 1,872
    1. Cell Biology

    Decoupling AMPK from fatty acid synthesis allows maintenance of fitness late in life

    Hanane Hadj-Moussa, Megan Ulusan ... Jonathan Houseley
    Re-engineering a highly conserved metabolic pathway in yeast prevents age-related functional decline and proves that ageing is not inevitably linked to loss of fitness.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    ATP-driven conformational dynamics reveal hidden intermediates in a heterodimeric ABC transporter

    Matija Pečak, Christoph Nocker, Robert Tampé
    Hidden outward-facing intermediates and long-lived ATP-bound states reveal how ATP binding drives conformational dynamics in the heterodimeric ABC transporter TmrAB.
    1. Neuroscience

    Comprehensive characterization of human color discrimination thresholds

    Fangfang Hong, Ruby Bouhassira ... David H Brainard
    Leveraging the smooth variation of internal noise makes comprehensive characterization of color discrimination practical, offering an efficient framework for studying perceptual limits across various sensory domains.
    1. Cell Biology
    2. Immunology and Inflammation

    Pink1-mediated mitophagy in the endothelium releases proteins encoded by mitochondrial DNA and activates neutrophil responses during inflammation

    Priyanka Gajwani, Li Wang ... Jalees Rehman
    Inflammatory activation of endothelial cells triggers Pink1-dependent mitophagy and mitochondrial formyl peptides release, which drives neutrophil recruitment and lung injury.
    1. Structural Biology and Molecular Biophysics

    Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching

    Kexin Zhang, Timothy Grant, Nikolaus Grigorieff
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Neuroscience

    A hierarchical coordinate system for sequence memory in human entorhinal cortex

    Anna Shpektor, Jacob JW Bakermans ... Timothy EJ Behrens
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Biochemistry and Chemical Biology

    Glycolipid MPIase is essential for the TAT (Twin-Arginine Translocation) pathway

    Hanako Nishikawa, Nachi Yamamoto ... Ken-ichi Nishiyama
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Solid
    1. Neuroscience

    Neural correlates of perceptual consciousness from within: A narrative review of human intracranial research

    François Stockart, Alexis Robin ... Nathan Faivre
    Combining intracranial recordings with no-report paradigms and computational models offers the clearest path yet to isolating genuine neural correlates of consciousness from their prerequisites and consequences.