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    1. Cancer Biology

    Targeting Polθ Helicase with RP-3467: Preclinical Validation and Clinical Response in a gBRCA1 ovarian cancer patient with an acquired PARPi resistance mutation in TP53BP1

    Ezra Y Rosen, Marie-Claude Mathieu ... Agnel Sfeir
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Female acoustic signaling of sexual immaturity depresses male courtship in Drosophila

    Martin Bernet, Anne C von Philipsborn
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Dual reinforcement-learning network modules for modeling decision-making with multiple strategies

    Hayato Maeda, Shuo Wang, Akihiro Funamizu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Developmental Biology
    2. Neuroscience

    A comparative single-cell transcriptomic atlas for diverse populations of vertebrate hair cells

    Mahashweta Basu, Nesrine Benkafadar ... Lisa V Goodrich
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    A complementary learning system for continual episodic memory in large language models

    Xu Pan, Ely Hahami ... Haim Sompolinsky
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Stem Cells and Regenerative Medicine

    Stimulating neurogenesis of distinct retinal lineages in human retinal pigmented epithelium (RPE) with proneural transcription factors

    Lew Kaplan, Abigail L Green ... Thomas A Reh
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in colorectal cancer

    Qian Wang, Liping Li ... Chuo Chen
    Catalytic inhibition of tankyrase induces tankyrase accumulation and rigidifies the β-catenin destruction complex, limiting its ability to suppress WNT signaling.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

    Sarah M Chang, Muhammad Bin Munim ... Matthew G Vander Heiden
    Examining the metabolic response of cancer cells to nutrient depletion reveals how the cell NAD+/NADH ratio can determine what nutrient environments are compatible with cancer cell proliferation.
    1. Genetics and Genomics
    2. Medicine

    Estimating bone marrow adiposity from head MRI and identifying its genetic architecture

    Tobias Kaufmann, Pål Marius Bjørnstad ... Timothy Hughes
    Previously overlooked information in standard head MRI scans combined with a novel deep learning method enables large-scale investigation of human bone marrow biology across existing imaging cohorts.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Cryo-electron tomography sheds light on the largest protein in the Trypanosoma brucei tripartite attachment complex

    Irina Bregy, Robin Benjamin Eberle ... Torsten Ochsenreiter
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
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