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    1. Genetics and Genomics

    Stranded short nascent strand sequencing reveals the topology of DNA replication origins in Trypanosoma brucei

    Slavica Stanojcic, Bridlin Barckmann ... Yvon Sterkers
    Replication origins in Trypanosoma brucei integrate multiple features previously described individually in opisthokonts, revealing a unified structural topology built from strand-specific nucleotide composition, G‑quadruplex enrichment, and distinctive nucleosome patterns.
    1. Neuroscience

    Drug-induced changes in connectivity to midbrain dopamine cells revealed by rabies monosynaptic tracing

    Katrina Bartas, Pieter Derdeyn ... Kevin T Beier
    Addictive drugs, as well as ketamine/xylazine, change the connectivity to ventral tegmental area dopamine cells, which may be related to cellular activity.
    1. Cancer Biology
    2. Developmental Biology

    Tumors mimic the niche to inhibit neighboring stem cell differentiation

    Yang Zhang, Yuejia Wang ... Shaowei Zhao
    Drosophila female germline tumors mutant for bam or bgcn mimic the stem cell niche to inhibit the differentiation of neighboring wild-type germline stem cells.
    1. Biochemistry and Chemical Biology

    The role of ATP synthase subunit e (ATP5I) in mediating the metabolic and antiproliferative effects of metformin in cancer cells

    Guillaume Lefrançois, Emilie Lavallée ... Gerardo Ferbeyre
    Biochemical and genetic evidence identifies ATP5I as a biguanide target, redefining biguanide action through ATP synthase regulation and assembly, mitochondrial architecture, and mitochondrial protein turnover.
    1. Neuroscience

    Bilateral equalization of synaptic output in olfactory glomeruli of Xenopus tadpoles

    Marta Casas, Beatrice Terni, Artur Llobet
    A novel bilateral compensatory mechanism important for the activity of olfactory glomeruli in Xenopus tropicalis tadpoles was uncovered.
    1. Developmental Biology

    The NTR/Prodrug Revolution: Tools for Controlling Cell Loss and Regeneration

    Gha-Hyun J Kim, Michael J Parsons
    Revised
    Reviewed Preprint v2
    Updated
    1. Developmental Biology

    Stemness factor Mex3a times translation and protein trafficking to ensure robust differentiation of olfactory sensory neurons

    Martín Escamilla del Arenal, Lauren C Tang ... Rachel Duffié
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cell Biology

    Zasp52’s differentially expressed intrinsically disordered region confers thin filament stability at the Z-disc

    Nikolai Ho, Frieder Schöck
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Medicine

    Platelets promote acute liver injury via extracellular vesicles-mediated Aldolase A

    Ruoxue Yang, Jinghua Liu ... Zhao Shan
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Chromosomes and Gene Expression

    Uncoupling the TFIIH Core and Kinase Modules Leads To Misregulated RNA Polymerase II CTD Serine 5 Phosphorylation

    Gabriela Giordano, Robin Buratowski ... Stephen Buratowski
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
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