Browse our latest research

Page 2 of 1,864
    1. Neuroscience

    Analysis of dendritic input currents during place field dynamics

    Bence Fogel, Balazs B Ujfalussy
    A new analysis method to measure the propagation of different membrane currents along complex dendritic trees reveals the conditions leading to burst firing in a computational model of place cells.
    1. Computational and Systems Biology

    TopoMetry systematically learns and evaluates the latent geometry of single-cell data

    David Sidarta-Oliveira, Ana I Domingos, Licio A Velloso
    A framework for analyzing single-cell genomics data, in which geometrical properties are harnessed to obtain insights on cellular diversity, including precise clustering, clear visualizations, and intuitive diagnostics.
    1. Medicine

    Navigating the path: Advice to physician-scientists on choosing a clinical specialty

    Talia Swartz, Jose E Cavazos ... Christopher S Williams
    This article provides critical insights in guiding aspiring physician-scientist medical students on how to choose a clinical specialty.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Non-canonical amino acid incorporation enables minimally disruptive labeling of stress granule and TDP-43 proteinopathy

    Hao Chen, Haocheng Wang ... Jiou Wang
    Minimally disruptive genetic code expansion enables faithful, site-specific labeling of G3BP1 and TDP-43, revealing native stress granule dynamics and ALS-linked protein behavior in live cells.
    1. Neuroscience

    Neural activity profiles reveal overlapping, intermingled subpopulations spanning area borders in mouse sensorimotor cortex

    Sohrab Salimian, Harrison Grier, Matthew Tyler Kaufman
    Single neurons in mouse sensorimotor cortex are organized by their activity features into distinct subpopulations with area-spanning footprints whose boundaries align closely with anatomical and somatotopic borders.
    1. Cell Biology

    Nuclear export modulates TDP-43 phase transition and cytoplasmic aggregation

    Natalie Chin, Qi Zhang ... Yihong Ye
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Developmental Biology

    Genome-wide discovery of cis-regulatory elements in a large genome

    Gillian Forbes, Emilia Skafida ... Mathilde Paris
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Cell Biology

    Membrane contact site resident PTP1B limits superoxide production by suppressing a Syk-Shc1-Phagocyte Oxidase relay

    Minhyoung Lee, Haggag S Zein ... Gregory D Fairn
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Medicine

    Large-scale synthetic data enable digital twins of human excitable cells

    Pei-Chi Yang, Mao-Tsuen Jeng ... Colleen E Clancy
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Mood computational mechanisms underlying increased risk behavior in adolescent suicidal patients

    Zhihao Wang, Tian Nan ... Bastien Blain
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing