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    1. Cell Biology

    Defective Neuronal Differentiation in Lowe Syndrome is Associated with Mitochondrial Dysfunction and Impaired Cilia-related Sonic Hedgehog Signaling

    Grzegorz Walkiewicz, Siyu Chen ... Yang Sun
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Evolutionary Biology

    The population structure of invasive Lantana camara is shaped by its mating system

    P Praveen, Rajesh Gopal, Uma Ramakrishnan
    Invasive Lantana camara exhibits strong genetic structure, unlike many invasive species, likely driven by predominant self-fertilization across its invasive range rather than the presence of multiple species.
    1. Computational and Systems Biology

    Large-scale synthetic data enable digital twins of human excitable cells

    Pei-Chi Yang, Mao-Tsuen Jeng ... Colleen E Clancy
    Large-scale synthetic datasets enable construction of digital twins of individual human excitable cells from a single voltage-clamp recording.
    1. Structural Biology and Molecular Biophysics

    Structural dynamics of IRE1 and its interaction with unfolded peptides

    Elena Spinetti, Grzegorz Ścibisz ... Roberto Covino
    A unified structural model of IRE1 activation reconciles conflicting sensing theories by characterizing specific peptide-binding sites and the mechanism by which BiP regulates oligomerization during the unfolded protein response.
    1. Computational and Systems Biology

    Functional muscle networks as biomarkers of post-stroke motor impairment and therapeutic responsiveness

    David O'Reilly, Giorgia Pregnolato ... Giacomo Severini
    The proposed muscle network analysis framework identifies a redundancy-to-synergy shift as a marker of stroke recovery, yielding new biomarkers that could objectively quantify functional impairment and rehabilitation efficacy.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A tool to pulse-label yeast Nuclear Pore Complexes in imaging and biochemical experiments

    Annemiek C Veldsink, Jonas S Fischer ... Liesbeth M Veenhoff
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Zapit: Open Source Laser-Scanning Photostimulation For Neuroscience

    Michael Lohse, Oliver M Gauld ... Robert AA Campbell
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology

    Identification of key Y4R residues enables the discovery of selective non-peptide small-molecule agonists

    Tim Pelczyk, Corinna Schüß ... Annette G Beck-Sickinger
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Plant Biology
    2. Ecology

    Asymmetric introgression and thermal advantage jointly drive climate-mediated lineage turnover in a mixed-ploidy reed

    Lele Liu, Wenyi Sheng ... Weihua Guo
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Convincing
    1. Cell Biology
    2. Physiology

    Aging induced structural alterations in SR-Mitochondria interaction in skeletal muscle: Emerging insights

    Unmod Senapati, Barsha Priyadarshini Kar ... Naresh Chandra Bal
    Not revised
    Reviewed Preprint v1
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