Browse our latest research

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    1. Genetics and Genomics

    Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome

    Tanja Nielsen, Anaïs Kervadec ... Alexandre R Colas
    Cross-species functional genomics identify ribosomal protein genes as key regulators of cardiomyocyte proliferation and heart development, implicating them as candidate modifiers for HLHS and revealing new avenues for therapeutic discovery.
    1. Biochemistry and Chemical Biology

    General trends in the calnexin-dependent expression and pharmacological rescue of clinical CFTR variants

    Austin Tedman, John A Olson ... Jonathan P Schlebach
    Combining deep mutational scanning with CRISPR, interactome measurements, and electrophysiology reveals nuanced effects of the lectin chaperone calnexin on the pharmacological properties of 232 cystic fibrosis variants.
    1. Evolutionary Biology
    2. Neuroscience

    A single-cell transcriptomic atlas reveals resident dendritic-like cells in the zebrafish brain parenchyma

    Mireia Rovira, Giuliano Ferrero ... Valerie Wittamer
    The zebrafish brain combines a conserved heterogeneity of immune cells with a unique dendritic cell-like population.
    1. Physics of Living Systems

    Advantageous and disadvantageous inequality aversion can be taught through learning of others’ preferences

    Shen Zhang, Oriel FeldmanHall ... A Ross Otto
    Like disadvantageous inequity aversion, advantageous inequity aversion can be learned by observing another’s fairness preferences.
    1. Cell Biology
    2. Developmental Biology

    The oocyte zinc transporter Slc39a10/Zip10 is a regulator of zinc sparks during fertilization in mice

    Atsuko Kageyama, Narumi Ogonuki ... Junya Ito
    The zinc transporter Slc39a10/Zip10 is important for zinc homeostasis during fertilization and embryonic development in mice.
    1. Evolutionary Biology

    Integration of multi-level dental diversity links macro-evolutionary patterns to ecological strategies across sharks

    Roland Zimm, Vitória Tobias Santos, Nicolas Goudemand
    Shark dentition is a complex and hyper-diverse trait integrating multiple spatial levels, with mid-scale features being most crucial for functional adaptation, revealing evolutionary patterns that offer insights into distinct ecological strategies.
    1. Cancer Biology

    Mitochondrial Protein Carboxyl-Terminal Alanine-Threonine Tailing Promotes Glioblastoma Tumor Growth by Regulating Mitochondrial Function

    Bei Zhang, Ting Cai ... Zhihao Wu
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Neuroscience

    Causal evidence for a domain-specific role of left superior frontal sulcus in human perceptual decision making

    Miguel Barretto García, Marcus Grueschow ... Christian C Ruff
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Evolution of a fuzzy ribonucleoprotein complex in viral assembly

    Huaying Zhao, Tiansheng Li ... Peter Schuck
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Decision-making components and times revealed by the single-trial electro-encephalogram

    Gabriel Weindel, Jelmer P Borst, Leendert van Maanen
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing