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    1. Computational and Systems Biology

    Permute-match tests detect significant correlations between time series despite nonstationarity and limited replicates

    Alex E Yuan, Wenying Shou
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Neuroscience

    Thalamo-accumbal circuit adaptations following extended oxycodone abstinence

    Yanaira Alonso-Caraballo, Yan Li ... Elena H Chartoff
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Compelling
    1. Developmental Biology

    Junctional β-Catenin Stabilization Links Wnt Signaling and Force Generation

    Agimaa Otgonbaatar, Sujithra Shankar ... Nicholas S Tolwinski
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Medicine
    2. Immunology and Inflammation

    TLR4 signaling drives tissue inflammation, Claudin-5 internalization, and vascular barrier breakdown in a mouse model of neonatal meningitis

    Philip V Seegren, Amir Rattner ... Jeremy Nathans
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Identifying molecular instructions to hard-wire a sensory neuron’s synaptic connectivity

    Júnia Vieira dos Santos, Renee Yin Yu ... Brian E Chen
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Medicine

    Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injury

    Yaying Zhu, Chengxiang Deng ... Zhao Shan
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Incomplete
    1. Cell Biology

    CROP2, a Retriever–PROPPIN complex mediating protein export from endosomes to the plasma membrane in human cells

    Maria Giovanna De Leo, Andreas Mayer
    Endosomes operate several exit routes that sort protein cargo and depend on pathway-specific associations of a PROPPIN with the responsible protein coat, such as the here identified CROP2, to support the departure of the cargo carriers.
    1. Cancer Biology

    JAK-STAT Pathway Heterogeneity Governs Immunotherapy Response in Breast Cancer

    Jianbo Zhou, Heng Zhang ... Fu Peng
    Revised
    Reviewed Preprint v3
    Updated
    • Fundamental
    • Convincing
    1. Developmental Biology
    2. Genetics and Genomics

    Multiple Molecular Pathways to Longevity: Opposing Gene Expression Programs Define Distinct Aging Strategies

    Zenith D Rudich, Jiaxi Guan ... Jeremy M Van Raamsdonk
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Genetics and Genomics

    RiboTRAP-seq identifies spatially distinct functions for the anterior and posterior intestine in immune and metabolic regulation in C. elegans

    Chung-Chih Liu, Nicolas Seban, Supriya Srinivasan
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
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