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    1. Genetics and Genomics
    2. Neuroscience

    Morphine regulates astrocyte transcriptional dynamics in the ventral tegmental area by stimulation of glucocorticoid signaling

    Jennifer J Tuscher, Angela Cleere ... Jeremy J Day
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Adult-neurogenesis allows for representational stability and flexibility in early olfactory system

    Zhen Chen, Krishnan Padmanabhan
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Incomplete
    1. Computational and Systems Biology

    Fully computational design of PAM-relaxed Staphylococcus aureus Cas9 with expanded targeting capability using UniDesign

    Youcai Xiong, Li-Kuang Tsai ... Xiaoqiang Huang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Ecology

    Full factorial construction of synthetic microbial communities

    Juan Diaz-Colunga, Pablo Catalan ... Alvaro Sanchez
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Redirection of SARS-CoV-2 to Phagocytes by Intranasal sACE2-Fc as a Universal Decoy Confers Complete Prophylactic Protection

    Jingyi Wang, Jiangchuan Li ... Bo Feng
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Neuroscience

    Reassessing prediction in the brain: Pre-onset neural encoding during natural listening does not reflect pre-activation

    Sahel Azizpour, Britta U Westner ... Linda Geerligs
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Physics of Living Systems

    Colony demographics shape nest construction in Camponotus fellah ants

    Harikrishnan Rajendran, Roi Weinberger ... Ofer Feinerman
    The architecture of an ant nest serves as a fossilized record of the colony's demographic history, with distinct growth patterns and catastrophic events through age-specific digging behaviors.
    1. Cell Biology
    2. Immunology and Inflammation

    Clathrin-independent endocytosis and retrograde transport in cancer cells tune immune synapse organization and CD8 T cell response

    Shiqiang Xu, Alix Buridant ... Henri-François Renard
    Endophilin-A3-mediated clathrin-independent endocytosis and retrograde trafficking in cancer cells regulate ICAM1 organization at the immune synapse and influence cytotoxic CD8 T cell response.
    1. Developmental Biology
    2. Immunology and Inflammation

    HEB collaborates with TCR signaling to upregulate Id3 and enable γδT17 cell maturation in the fetal thymus

    Johanna S Selvaratnam, Juliana DB da Rocha ... Michele Kay Anderson
    Dynamic regulation of the E-protein/Id axis links TCR signaling to the maturation of IL-17-producing γδ T cells.
    1. Structural Biology and Molecular Biophysics

    SMC complex unidirectionally translocates DNA by coupling segment capture with an asymmetric kleisin path

    Masataka Yamauchi, Giovanni Bruno Brandani ... Shoji Takada
    An asymmetric kleisin path breaks the symmetry of the SMC homodimer, ensuring unidirectional DNA translocation via a segment capture mechanism.
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