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    1. Cell Biology

    Defective Neuronal Differentiation in Lowe Syndrome is Associated with Mitochondrial Dysfunction and Impaired Cilia-related Sonic Hedgehog Signaling

    Grzegorz Walkiewicz, Siyu Chen ... Yang Sun
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Neuroscience

    Excitation–inhibition balance controls coupling stability and network reorganization in a plastic Kuramoto model

    Satoshi Kuroki, Kenji Mizuseki
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Genetics and Genomics

    RiboTRAP-seq identifies spatially distinct functions for the anterior and posterior intestine in immune and metabolic regulation in C. elegans

    Chung-Chih Liu, Nicolas Seban, Supriya Srinivasan
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology

    ᴅ-serine suppresses one-carbon metabolism by competing with mitochondrial ʟ-serine transport

    Masataka Suzuki, Kenichiro Adachi ... Jumpei Sasabe
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Cell Biology

    Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidification and rupture

    Jessica Tittelmeier, Carl Alexander Sandhof ... Carmen Nussbaum-Krammer
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cancer Biology

    JAK-STAT Pathway Heterogeneity Governs Immunotherapy Response in Breast Cancer

    Jianbo Zhou, Heng Zhang ... Fu Peng
    Revised
    Reviewed Preprint v3
    Updated
    • Fundamental
    • Convincing
    1. Developmental Biology
    2. Genetics and Genomics

    Multiple Molecular Pathways to Longevity: Opposing Gene Expression Programs Define Distinct Aging Strategies

    Zenith D Rudich, Jiaxi Guan ... Jeremy M Van Raamsdonk
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Frequency and Laminar Profile of Feature Specific Visual Activity Revealed by Interleaved EEG-fMRI

    Tommy Clausner, José P Marques ... Mathilde Bonnefond
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Structural dynamics of IRE1 and its interaction with unfolded peptides

    Elena Spinetti, Grzegorz Ścibisz ... Roberto Covino
    A unified structural model of IRE1 activation reconciles conflicting sensing theories by characterizing specific peptide-binding sites and the mechanism by which BiP regulates oligomerization during the unfolded protein response.
    1. Computational and Systems Biology

    Large-scale synthetic data enable digital twins of human excitable cells

    Pei-Chi Yang, Mao-Tsuen Jeng ... Colleen E Clancy
    Large-scale synthetic datasets enable construction of digital twins of individual human excitable cells from a single voltage-clamp recording.
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