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    1. Physics of Living Systems

    Cell strain-stiffening drives cell breakout from embedded spheroids

    Shabeeb Ameen, Kyungeun Kim ... Tao Zhang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics

    In-cell cryo-electron tomography reveals differential effects of type I and type II kinase inhibitors on LRRK2 filament formation and microtubule association

    Tamar Basiashvili, Joshua Hutchings ... Elizabeth Villa
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Training neural networks from scratch in a videogame leads to brittle brain encoding

    François Paugam, Basile Pinsard ... Lune Bellec
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Neuroscience

    Confidence phenotypes: a unified computational account of value and decision certainty in reinforcement learning

    Nicolás A Comay, Guillermo Solovey, Pablo Barttfeld
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Opposing BOLD signals and oxygen metabolism largely arise from statistical uncertainty in metabolic estimates

    Ole Goltermann, Alexander Huth, Christian Büchel
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Physiology

    Optical single-channel recording of CRAC channels with HaloTag and a Ca2+-sensitive ligand

    Harsharan Dhillon, Richard S Lewis
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Epigenetic and 3D Genome Changes Drive Primary Trastuzumab Resistance in HER2+ Breast Cancer

    Ningjun Duan, Yijia Hua ... Yongmei Yin
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    From multiplicity of infection to force of infection in sparsely sampled high-transmission Plasmodium falciparum populations

    Qi Zhan, Kathryn E Tiedje ... Mercedes Pascual
    Queuing theory links multiplicity of infection (MOI) to force of infection (FOI), enabling the estimation of transmission intensity for falciparum malaria (and other infectious diseases) from sparsely sampled surveys.
    1. Structural Biology and Molecular Biophysics

    Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling

    Nevin K Zacharia, Stefanie Kuhns ... Esben Lorentzen
    The IFT172 C-terminus bridges IFT-A and IFT-B complexes through mutually exclusive interactions with IFT140 and IFT144, and harbors a U-box-like domain linking intraflagellar transport to ubiquitin-dependent ciliary signaling.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Patient-specific midbrain organoids with CRISPR correction recapitulate neuronopathic Gaucher disease phenotypes and enable evaluation of novel therapies

    Yi Lin, Benjamin Liou ... Ying Sun
    Human midbrain organoids provide a foundation for the development of patient-specific preclinical models to support personalized therapeutic approaches and enable evaluation of disease mechanisms and therapeutic strategies in human context.
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