Browse the latest research

18,506 results found
    1. Microbiology and Infectious Disease

    A dual role for PGLYRP1 in host defense and immune regulation during B. pertussis infection

    David M Rickert, Sasha Cardozo ... Ciaran Skerry
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Squidly: Enzyme Catalytic Residue Prediction Harnessing a Biology-Informed Contrastive Learning Framework

    William JF Rieger, Mikael Boden ... Ariane Mora
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Investigating the native functions of [NiFe]-carbon monoxide dehydrogenases through genomic context analysis

    Maximilian Böhm, Henrik Land
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Perceptual predictions track subjective, over objective, statistical structure

    Jessye Clarke, Kirsten Rittershofer ... Clare Press
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    SMC complex unidirectionally translocates DNA by coupling segment capture with an asymmetric kleisin path

    Masataka Yamauchi, Giovanni B Brandani ... Shoji Takada
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology
    2. Immunology and Inflammation

    Male-Biased Cyp17a2 Orchestrates Antiviral Sexual Dimorphism in Fish via STING Stabilization and Viral Protein Degradation

    Long-Feng Lu, Bao-jie Cui ... Shun Li
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Deletion of the moeA gene in Flavobacterium IR1 drives structural color shift from green to blue and alters polysaccharide metabolism

    Álvaro Escobar Doncel, Constantinos Patinios ... Colin J Ingham
    Disrupting a single molybdenum cofactor gene allowed us to connect metabolic regulation of complex carbohydrates with cell organization, enabling genetic tuning of bacterial structural color for biomaterial applications.
    1. Neuroscience

    Differential destinations, dynamics, and functions of high- and low-order features in the feedback signal during object processing

    Wenhao Hou, Sheng He, Jiedong Zhang
    Feedback signals to the early visual cortex convey both high-order and low-order visual information, but with different laminar profiles, and the high-order information is important for object recognition.
    1. Cell Biology

    Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (p97-PROTAC)

    Constanza Salinas-Rebolledo, Javier Blesa ... Alejandro Rojas-Fernandez
    Synthetic adaptors combining camelid nanobodies with the UBX domain of the p97 adaptor FAF1 enable targeted substrate delivery to p97, establishing an E3 ubiquitin ligase-independent mechanism for selective protein degradation.
    1. Computational and Systems Biology

    Targeted Computational Design of an Interleukin-7 Superkine with Enhanced Folding Efficiency and Immunotherapeutic Efficacy

    See-Khai Lim, Wen-Ching Lin ... Kurt Yun Mou
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
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