Browse the latest research

18,852 results found
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the bicarbonate receptor GPR30

    Shota Kaneda, Airi Jo-Watanabe ... Osamu Nureki
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Cell Biology

    An ancient transcription factor functions as the master regulator of primary cilia formation

    Weihua Wang, Xiqi Zhang ... Zhangfeng Hu
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cell Biology
    2. Computational and Systems Biology

    Geometry shapes cytoplasmic Cdk1 waves that drive cortical dynamics

    Daniel Cebrián-Lacasa, Marcin Leda ... Lendert Gelens
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Immunology and Inflammation

    Selective JAK Inhibition Reveals Paradoxical and Hierarchical Control of interferon-γ-driven Autoimmunity in AIRE Deficiency

    Eliezer Heller, Lucas dos Santos Dias, Michail S Lionakis
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Dichotomy between extracellular signatures of active dendritic chemical synapses and gap junctions

    Richa Sirmaur, Rishikesh Narayanan
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Biochemistry and Chemical Biology

    Purified Zymogens Reveal Mechanisms of Snake Venom Metalloproteinase Auto-Activation

    Sophie Hall, Iara Aimê Cardoso ... Christiane Schaffitzel
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Developmental Biology

    HSD17B7 is required for the function of sensory hair cells by regulating cholesterol synthesis

    Yuqian Shen, Ziyang Wang ... Dong Liu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Physics of Living Systems

    Collective epithelial migration mediated by the unbinding of hexatic defects

    Dimitrios Krommydas, Livio N Carenza, Luca Giomi
    Theoretical and computational analyses demonstrate that cell intercalation within epithelial cell layers is analogous to the unbinding of topological defects in hexatic liquid crystals, offering a framework for calculating cellular forces and velocities during collective migration.
    1. Neuroscience

    Auditory perception and neural representation of temporal features are altered by age but not by cochlear synaptopathy

    Friederike Steenken, Rainer Beutelmann ... Georg M Klump
    In aging gerbils, compromised temporal fine structure perception is explained by a more prominent representation in auditory nerve fibers of temporal fluctuations of the signal envelope, rather than by synaptopathy.
    1. Neuroscience

    Hugin-AstA circuitry is a novel central energy sensor that directly regulates sweet sensation in Drosophila and mouse

    Wusa Qin, Tingting Song ... Rui Huang
    A conserved neuropeptidergic circuit directly links internal glucose levels to sweet taste sensitivity, providing a central mechanism for coupling metabolic state to feeding behavior.

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