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19,238 results found
    1. Cell Biology
    2. Physics of Living Systems

    Sarcomere dynamic instability and stochastic heterogeneity drive robust cardiomyocyte contraction

    Daniel Haertter, Lara Hauke ... Christoph F Schmidt
    A non-monotonic force–velocity relationship in cardiac sarcomeres causes dynamic instability, leading to stochastic heterogeneity in contracting cardiomyocytes, which can have a protective function.
    1. Neuroscience

    Auditory cortical feedback signals are modulated during songbird courtship

    Caleb Jones, Jesse H Goldberg
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Zebrafish Rif1 impacts zygotic genome activation, replication timing, and sex determination

    Emily A Masser, Tyler D Noble ... Christopher L Sansam
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Distinct allosteric remodeling of HIV-1 Env dynamics on virions by gp41-directed antibodies reveals two modes of neutralization

    Wang Xu, Narendra Kumar Gonepudi ... Maolin Lu
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Dissociable Roles of Reward Prediction Error in the Contrasting Mood Dynamics of Depression and Anxiety

    Zhihao Wang, Ting Wang ... Pengfei Xu
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Plant Biology
    2. Evolutionary Biology

    Adaptation of an herbivorous arthropod to green tea plants by overcoming catechin defenses

    Naoki Takeda, Brendan Abiskaroon ... Takeshi Suzuki
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology

    Distinct Mechanisms for Inhibition of SARS-CoV-2 Main Protease: Dimerization Promoted by Peptidomimetic Inhibitors and Disrupted by Ebselen

    Chengxi Liu, Qinyu Jia ... Zhong-Ping Yao
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    PKD2L1 channels segregated to the apical compartment are the dual-mode pH sensor in cerebrospinal fluid-contacting neurons

    Magdalena Vitar, Daniel Prieto ... Federico F Trigo
    Revised
    Reviewed Preprint v3
    Updated
    • Fundamental
    • Compelling
    1. Evolutionary Biology
    2. Genetics and Genomics

    Intersecting experimental evolution and CRISPR screens to identify novel toxin resistance loci

    Michele Marconcini, Steeve Cruchet ... Richard Benton
    Selection of animal populations and of cultured cells provides complementary datasets to identify candidate genes involved in conferring resistance to a natural insecticide.
    1. Cancer Biology

    Nerve injury-induced protein 2 preserves lysosomal membrane integrity to suppress ferroptosis

    Jin Zhang, Miranda Bustamante ... Xinbin Chen
    Revealing a role for NINJ2 in maintaining lysosomal homeostasis and preventing ferroptosis, laying the foundation for the development of cancer therapeutics targeting NINJ2.
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