Highlights

  • The safety-efficiency dilemma

    The Pavlovian fear system has a larger role in decision-making than previously thought, helping to keep it both safe and efficient during exploratory behaviour.

    Pranav Mahajan, Shuangyi Tong ... Ben Seymour
    Research Article
  • New university partnerships

    eLife is partnering with two leading UK universities on open access agreements that promote a more open and equitable approach to scientific publishing.

    Press Pack
  • Inside a thylakoid membrane

    The molecular architecture of the thylakoid membrane in a vascular plant has been determined with single-molecule precision.

    Wojciech Wietrzynski, Lorenz Lamm ... Benjamin D Engel
    Research Advance
  • Enzyme production in fungi

    The secretion of enzymes by A. oryzae, a filamentous fungus with multiple nuclei that is widely used in food production, increases with cell volume and nuclear number.

    Ayaka Itani, Haruto Motomura ... Norio Takeshita
    Research Article
  • The benefits of disorder

    The presence of an intrinsically disordered region in a transcription factor enhances both target binding and search efficiency.

    Wencheng Ji, Ori Hachmo ... Ariel Amir
    Research Article
  • Tracing cell fates in embryos

    Differences in the activity of an enzyme called CARM1 influence whether blastomeres become part of the embryo or the placenta.

    Ying Zhang, Qi Chen
    Insight

Latest research

    1. Microbiology and Infectious Disease

    Heterogeneity of Genetic Sequence within Quasi-species of Influenza Virus Revealed by Single-Molecule Sequencing

    Kenji Tamao, Hiroyuki Noji, Kazuhito V Tabata
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Functional connectivity, structural connectivity, and inter-individual variability in Drosophila melanogaster

    Takuto Okuno, Alexander Woodward ... Junichi Hata
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience
    2. Physics of Living Systems

    A Deep Learning Pipeline for Mapping in situ Network-level Neurovascular Coupling in Multi-photon Fluorescence Microscopy

    Matthew Rozak, James Mester ... Bojana Stefanovic
    Revised
    Reviewed Preprint v4
    Updated
    • Valuable
    • Solid
    1. Computational and Systems Biology

    TrueProbes: Quantitative Single-Molecule RNA-FISH Probe Design Improves RNA Detection

    Jason J Hughes, Benjamin K Kesler ... Gregor Neuert
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Immunology and Inflammation

    Layers of immunity: Deconstructing the Drosophila effector response

    Faustine Ryckebusch, Yao Tian ... Bruno Lemaitre
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Immunology and Inflammation
    2. Evolutionary Biology

    Evolutionary Adaptations of IRG1 Refines Itaconate Synthesis and Mitigates Innate Immunometabolism Trade-offs

    Richard V Szeligowski, Francois Miros ... Hongying Shen
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Plant Biology

    Life-cycle-related gene expression patterns in the brown algae

    Pélagie Ratchinski, Olivier Godfroy ... J Mark Cock
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    When word order matters: human brains represent sentence meaning differently from large language models

    James Fodor, Carsten Murawski, Shinsuke Suzuki
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Nocebo effects are stronger and more persistent than placebo effects in healthy individuals

    Angelika Kunkel, Katharina Schmidt ... Ulrike Bingel
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Ecology

    Desmodium volatiles in ‘push-pull’ cropping systems and protection against the fall armyworm, Spodoptera frugiperda

    Daria M Odermatt, Frank Chidawanyika ... Meredith C Schuman
    'Push-pull' agro-ecosystems appear to protect maize against the fall armyworm, but volatiles from Desmodium intercrops are not sufficient to reliably repel this herbivore, indicating that additional mechanisms contribute to protection.