Highlights

  • The safety-efficiency dilemma

    The Pavlovian fear system has a larger role in decision-making than previously thought, helping to keep it both safe and efficient during exploratory behaviour.

    Pranav Mahajan, Shuangyi Tong ... Ben Seymour
    Research Article
  • Inside a thylakoid membrane

    The molecular architecture of the thylakoid membrane in a vascular plant has been determined with single-molecule precision.

    Wojciech Wietrzynski, Lorenz Lamm ... Benjamin D Engel
    Research Advance
  • Genetic pathways in brown algae

    Life-cycle-related patterns of gene expression are conserved across the brown algae.

    Pélagie Ratchinski, Olivier Godfroy ... J Mark Cock
    Reviewed Preprint Updated
  • Is ‘number sense’ a sense?

    Experiments on domestic chicks shed light on the links between brain lateralization and the left-to-right mental number line.

    Toshiya Matsushima
    Insight
  • Tracing cell fates in embryos

    Differences in the activity of an enzyme called CARM1 influence whether blastomeres become part of the embryo or the placenta.

    Ying Zhang, Qi Chen
    Insight
  • New university partnerships

    eLife is partnering with two leading UK universities on open access agreements that promote a more open and equitable approach to scientific publishing.

    Press Pack

Latest research

    1. Genetics and Genomics

    BreakLoops: A New Feature for the Multi-Gene, Multi-Cancer Family History-Based Model, Fam3Pro

    Nicolas Kubista, Ryan Hernandez-Cancela ... Danielle Braun
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Immunology and Inflammation

    Lipopolysaccharide stimulates dynamic changes in B cell metabolism to promote proliferation

    Dana MS Cheung, Momchil Razsolkov ... J Simon C Arthur
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Neuroscience
    2. Evolutionary Biology

    A single-cell transcriptomic atlas reveals resident dendritic-like cells in the zebrafish brain parenchyma

    Mireia Rovira, Giuliano Ferrero ... Valérie Wittamer
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Cell Biology
    2. Developmental Biology

    BICC1 Interacts with PKD1 and PKD2 to Drive Cystogenesis in ADPKD

    Uyen Tran, Andrew J Streets ... Oliver Wessely
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Epigenetic delineation of the earliest cardiac lineage segregation by single-cell multi-omics

    Peng Xie, Xu Jiang ... Chengqi Lin
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Inadequate
    1. Cancer Biology

    Blocking Osteoprotegerin Reprograms Cancer Associated Fibroblast to Promotes Immune Infiltration into the Tumor Microenvironment

    Yao Wang, Hara Apostolopoulou ... Anil Bhushan
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Plant Biology

    Fifteenth century CE Bolivian maize reveals genetic affinities with ancient Peruvian maize

    Huan Chen, Amy Baetsen-Young ... Gabriel Wrobel
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Inadequate
    1. Medicine

    Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injury

    Yaying Zhu, Chengxiang Deng ... Zhao Shan
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Cell Biology
    2. Computational and Systems Biology

    Extrusion-modulated DnaA activity oscillations coordinate DNA replication with biomass growth

    Dengjin Li, Hai Zheng ... Chenli Liu
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing