Highlights

  • From disorder to stability

    An intrinsically disordered region in a scaffolding protein called Zasp52 is required to stabilize Z-discs in the indirect flight muscle in Drosophila.

    Nikolai Ho, Frieder Schöck
    Reviewed Preprint

  • Context-dependent behavior

    A region of the brain called the retrosplenial cortex has an important role in integrating contextual information and sensory stimuli in mice.

    Pol Bech, Robin F Dard ... Carl CH Petersen
    Reviewed Preprint Updated

  • Seeing movement

    Inhibitory feedback from GABAergic interneurons C2 and C3 is tied to neural computation of moving visual stimuli in Drosophila.

    Miriam Henning, Madhura D Ketkar ... Marion Silies
    Research Article

  • Publish-review-curate at eLife

    eLife is rethinking how research is reviewed and published.

    Timothy E Behrens, Yamini Dalal, Diane M Harper
    Editorial

  • Science under threat

    How should the scientific community respond to ideological attacks on science?

    Humberto J Debat
    Feature Article

  • How to respond to peer reviewers

    Responding to peer reviews is a crucial part of publishing, but early-career researchers are rarely taught about it.

    Eric Kalkhoven, Manon Kluijtmans
    Feature Article
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Neuroscience

    Experience shapes the transformation of olfactory representations along the cortico-hippocampal pathway

    Eleonore Schiltz, Martijn Broux ... Haesler Sebastian
    The representation of stimulus identity and experience is transformed from primary olfactory cortex to memory-related multisensory areas in the hippocampus.
    Version of Record
    Short Report
    • Important
    • Solid
    1. Developmental Biology
    2. Neuroscience

    Complementary vertebrate Wac models exhibit phenotypes relevant to DeSanto-Shinawi Syndrome

    Kang-Han Lee, April M Stafford ... Daniel Vogt
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Developmental Synchrony of Retinal Waves, Apoptosis, and Angiogenesis in Postnatal Retina

    Michael A Savage, Cori Bertram ... Evelyne Sernagor
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Evolutionary Biology

    Experimental evolution to thermal stress indicates climate resilience in a cosmopolitan arthropod

    Gaoke Lei, Huiling Zhou ... Shijun You
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Chromosomes and Gene Expression

    Uncoupling the TFIIH Core and Kinase Modules leads to misregulated RNA polymerase II CTD Serine 5 phosphorylation

    Gabriela Giordano, Robin Buratowski ... Stephen Buratowski
    The TFIIH subunit Tfb3/MAT1 can be split into two parts to uncouple the TFIIH kinase and DNA translocase modules, resulting in unfocused C-terminal domain phosphorylation.
    1. Neuroscience

    A comprehensive mechanosensory connectome reveals a somatotopically organized neural circuit architecture controlling stimulus-aimed grooming of the Drosophila head

    Steven A Calle-Schuler, Alexis Santana-Cruz ... Andrew M Seeds
    A synaptic-resolution map reveals how spatially organized touch pathways in the fly brain shape aimed head grooming through parallel excitatory circuits and inhibitory control.
    1. Microbiology and Infectious Disease

    Membrane binding controls the ATPase cycle and localization of MinD in Bacillus subtilis

    Helge Feddersen, Charlotte Dyckmans, Marc Bramkamp
    Dynamic relocalization of MinD in Bacillus subtilis arises from membrane binding of monomers and dimers with membrane-triggered ATP hydrolysis, suggesting MinE-like activators are unnecessary for Min system dynamics.
    1. Neuroscience

    Brain-wide arousal signals are segregated from movement planning in the superior colliculus of the macaque

    Richard Johnston, Matthew A Smith
    Arousal signals are present in the superior colliculus but appear to be organized in a way that they avoid directly triggering motor plans that lead to saccades.
    1. Structural Biology and Molecular Biophysics

    Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity

    Jordan M Mancl, Wenguang G Liang ... Wei-Jen Tang
    Integrative structural analysis identifies the structural basis and key residues responsible for IDE conformational dynamics that control the unfolding and selective degradation of amyloid peptides.
    1. Genetics and Genomics
    2. Neuroscience

    Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling

    Kasturi Biswas, Caroline Moore ... Michael M Francis
    Muscarinic cholinergic signaling links neural activity to organism‑wide transcriptional and proteostatic responses that protect against chronic oxidative stress.
Load more

Magazine

    1. Neuroscience

    Verbal Memory: Language acquisition in newborns

    Marcela Peña

  2. Episode 103: May 2026

    1. Neuroscience

    Visual Perception: Insights into perceptual learning

    Zhong-Lin Lu
    1. Neuroscience

    Neuroendocrinology: Surging towards a better understanding of ovulation

    Lillian Rose, Alexander S Kauffman
    1. Cell Biology
    2. Neuroscience

    Auditory Hair Cells: Examining the role of lipids in hearing

    Yein Christina Park, Angela Ballesteros

  6. Point of View: Science under threat around the world

    Humberto J Debat
    1. Biochemistry and Chemical Biology

    Lipid Transport: How membranes shape up for lipid transfer

    Takashi Hirashima, Toshiya Endo
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
  16. Physiology
  17. Plant Biology
  18. Stem Cells and Regenerative Medicine
  19. Structural Biology and Molecular Biophysics
Back to top