Highlights

  • Closing the neural tube

    High-throughput arrayed CRISPR interference screening of organoid models gives insight into genetic regulators of neural tube closure in humans.

    Roya E Huang, Giridhar M Anand ... Sharad Ramanathan
    Research Article

  • Mechanics of oncogenesis

    Integrative mechanobiological approaches provide insight into the biophysics of tissue-specific tumor growth.

    Amrapali Datta, Phanindra Dewan ... Medhavi Vishwakarma
    Research Article

  • Signals for retinal development

    Synchronous waves of activity in the developing retina of postnatal mice potentially involve purinergic signalling triggered by apoptotic retinal ganglia.

    Michael A Savage, Cori Bertram ... Evelyne Sernagor
    Reviewed Preprint Updated

  • Publish-review-curate at eLife

    eLife is rethinking how research is reviewed and published.

    Timothy E Behrens, Yamini Dalal, Diane M Harper
    Editorial

  • Hippocampal memory

    Genetic evidence highlights the roles of atypical protein kinase C isoforms in hippocampal late-phase long-term potentiation and long-term memory.

    Panayiotis Tsokas, Changchi Hsieh ... Todd Charlton Sacktor
    Research Advance

  • Science under threat

    How should the scientific community respond to ideological attacks on science?

    Humberto J Debat
    Feature Article
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Microbiology and Infectious Disease

    Five-layer systems analysis of Leishmania stage differentiation reveals an essential role for protein degradation in parasite development

    Pascale Pescher, Thibaut Douché ... Gerald F Späth
    Integrated multi-omics profiling provides evidence for coordinated changes across RNA turnover, translation, phosphorylation, and protein degradation during Leishmania differentiation, generating candidate therapeutic targets for leishmaniasis.
    1. Neuroscience

    Human brain-wide activation of sleep rhythms

    Haiteng Wang, Qihong Zou ... Yunzhe Liu
    Simultaneous EEG–fMRI recordings in 107 human participants link coupled slow oscillations and sleep spindles to thalamic coordination of hippocampal–prefrontal communication during deep sleep.
    1. Neuroscience

    Closed-loop neurofeedback reshapes preparatory brain states to bias subsequent pain processing

    Yinhua Zhang, Shuang Qiu ... Weiwei Peng
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    A shared neural code for gender across faces, bodies, and objects in the human brain

    Wenjie Liu, Xiqian Lu ... Yi Jiang
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Physiology

    Reproductive experience promotes permanent body growth independently of growth hormone

    Gabriel O de Souza, Willian O dos Santos ... Jose Donato
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Essential role for plasma membrane glutamate transporters in stimulus intensity coding in auditory neurons

    Tenzin Ngodup, Laurence O Trussell
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Hierarchical Neural Circuit Theory of Normalization and Inter-areal Communication

    Asit Pal, Shivang Rawat ... Stefano Martiniani
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Neural computations in the foveal and peripheral visual fields during active search

    Jie Zhang, Xiaocang Zhu ... Huihui Zhou
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    Individual differences drive social hierarchies in male mouse societies

    Jonathan R Reinwald, Sarah Ghanayem ... Wolfgang Kelsch
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Investigation of Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis

    Marie Shimogawa, Ming-Hao Li ... E James Petersson
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
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Magazine

    1. Epidemiology and Global Health

    Malaria Prevention: Using mathematical models to optimise mosquito net distribution

    Carlos A Prete Jr
    1. Plant Biology

    Mixotrophy: An updated view of glucose pathways in cyanobacteria

    José Manuel García-Fernández
  3. Mountain gorilla

    Episode 104: July 2026

    1. Cell Biology
    2. Developmental Biology

    Organ Development: Following your heart as it takes shape

    Alexandra Trouilloud, Nicole C Dubois
    1. Cancer Biology

    Tumor Biology: The two faces of JAK-STAT

    Qianying Lu, Yingyi Zhang
    1. Neuroscience

    Brain Mapping: Understanding the cellular architecture of Huntington’s disease

    Dorian Pustina
    1. Physics of Living Systems

    Vector Biology: The exquisite mechanics of a tsetse bite

    Katelyn Fealy, Álvaro Acosta-Serrano
  8. See more Magazine articles

Categories

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  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
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