Highlights

  • Re-evolving traits

    Hybridization chain reaction and confocal imaging reveal latent ocelli gene regulatory network expression in ant workers, with a role in partial re-evolution of caste-specific traits.

    Angelly Vasquez-Correa, Johanna Arnet ... Ehab Abouheif
    Research Article
  • Body size and urban survival

    A global study of 30,000 species reveals how body size affects whether wildlife thrives or struggles in cities.

    Corey T Callaghan, Diana E Bowler ... Thomas Merckx
    Research Article
  • T-cells target TB-infected cells

    Complementary human in vitro systems suggest a non-classical T-cell pathway contributing to immunity against Mycobacterium tuberculosis infection

    Matthew Milton, Sahar H Farag ... Salah Mansour
    Reviewed Preprint Updated
  • Publish-review-curate at eLife

    eLife is rethinking how research is reviewed and published.

    Timothy E Behrens, Yamini Dalal, Diane M Harper
    Editorial
  • AI in research communication

    eLife has partnered on a number of projects harnessing AI for improving human and machine reader engagement with research.

    Inside eLife
  • Science under threat

    How should the scientific community respond to ideological attacks on science?

    Humberto J Debat
    Feature Article

Latest research

    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The C3–C3aR axis modulates trained immunity in alveolar macrophages

    Alexander P Earhart, Alberto E Lopez ... Hrishikesh S Kulkarni
    Complement component C3, a key component of immune responses at mucosal sites, affects alveolar macrophage reprogramming via the C3aR.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Genetics and Genomics

    The genetic control of rapid genome content divergence in Arabidopsis thaliana

    Christopher J Fiscus, Daniel Koenig
    Repeat variation in wild Arabidopsis thaliana arises from centromere-proximal sequence changes and rare variants in DNA replication, repair, and methylation genes, consistent with purifying selection constraining genome expansion.
    1. Genetics and Genomics

    AGES for Ageing: Evaluating the auxin-inducible gene expression system for use in Drosophila ageing studies

    Taylor McGilvary, Kriti Gupta ... Nathan Woodling
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Neuroscience

    Supervised Domain Adaptation Mitigates Cross-Ethnicity Prediction Error in Neuroimaging-Based Cognitive Prediction

    Farzane Lal Khakpoor, William van der Vliet ... Narun Pat
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    WNK-SPAK/OSR1 signaling pathway facilitates ictal activity via reduced neuronal chloride extrusion rate

    Volodymyr I Dzhala, Fu Hung Shiu ... Kevin J Staley
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Selective loss of Nkx2.1-lineage neurons in the lateral septum alters the balance between novelty seeking and threat avoidance

    Miguel Turrero García, Diana N Tran ... Corey C Harwell
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Inhibition tunes prefrontal circuit dynamics to promote sociosexual behavior in female mice

    Elizabeth A Amadei, Pau Vilimelis Aceituno ... Benjamin F Grewe
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Fast-ripples are emergent properties of neuronal networks

    Laurent Sheybani, Yichen Qiu ... Matthew C Walker
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    The transcription factor BCL11A restores differentiation potential to aged oligodendrocyte progenitor cells

    Tanay Ghosh, Roey Baror ... Robin JM Franklin
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Neuroscience

    Designing optimal perturbation inputs for system identification in neuroscience

    Mikito Ogino, Daiki Sekizawa ... Masafumi Oizumi
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling