Highlights

  • The safety-efficiency dilemma

    The Pavlovian fear system has a larger role in decision-making than previously thought, helping to keep it both safe and efficient during exploratory behaviour.

    Pranav Mahajan, Shuangyi Tong ... Ben Seymour
    Research Article

  • Inside a thylakoid membrane

    The molecular architecture of the thylakoid membrane in a vascular plant has been determined with single-molecule precision.

    Wojciech Wietrzynski, Lorenz Lamm ... Benjamin D Engel
    Research Advance

  • Genetic pathways in brown algae

    Life-cycle-related patterns of gene expression are conserved across the brown algae.

    Pélagie Ratchinski, Olivier Godfroy ... J Mark Cock
    Reviewed Preprint Updated

  • Is ‘number sense’ a sense?

    Experiments on domestic chicks shed light on the links between brain lateralization and the left-to-right mental number line.

    Toshiya Matsushima
    Insight

  • Tracing cell fates in embryos

    Differences in the activity of an enzyme called CARM1 influence whether blastomeres become part of the embryo or the placenta.

    Ying Zhang, Qi Chen
    Insight

  • New university partnerships

    eLife is partnering with two leading UK universities on open access agreements that promote a more open and equitable approach to scientific publishing.

    Press Pack
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Ecology
    2. Physics of Living Systems

    The dominant–egalitarian transition in species-rich communities

    David A Kessler, Nadav M Shnerb
    A model of a species-rich neutral ecosystem, perturbed by environmental noise impacting each species differently, predicts that for large noise the community is dominated by a few species, while for weaker noise it is more egalitarian, with many significant species.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Degradation of LMO2 in T cell leukaemia results in collateral breakdown of transcription complex partners and causes LMO2-dependent apoptosis

    Naphannop Sereesongsaeng, Carole JR Bataille ... Terry H Rabbitts
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Genetics and Genomics
    2. Evolutionary Biology

    The Primate Major Histocompatibility Complex: A Case Study of Gene Family Evolution

    Alyssa Lyn Fortier, Jonathan K Pritchard
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Genetics and Genomics

    MerQuaCo: a computational tool for quality control in image-based spatial transcriptomics

    Naomi Martin, Paul Olsen ... Jack Waters
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Neuroscience

    Foveated metamers of the early visual system

    William F Broderick, Gizem Rufo ... Eero P Simoncelli
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Neuroscience

    Toward Robust Neuroanatomical Normative Models: Influence of Sample Size and Covariates Distributions

    Camille Elleaume, Bruno Hebling Vieira ... the Australian Imaging Biomarkers and Lifestyle flagship study of ageing
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Genetics and Genomics

    Independent Validation of Transgenerational Inheritance of Learned Pathogen Avoidance in Caenorhabditis elegans

    Aalimah Akinosho, Joseph Alexander ... Andrés Vidal-Gadea
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Adult-neurogenesis allows for representational stability and flexibility in early olfactory system

    Zhen Chen, Krishnan Padmanabhan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    HIF1A-mediated pathways promote euploid cell survival in chromosomally mosaic embryos

    Estefania Sanchez-Vasquez, Marianne E Bronner, Magdalena Zernicka-Goetz
    Aneuploid mosaic mouse embryos require hypoxia for survival, and understanding these pathways may inform new strategies to support embryo viability.
    1. Neuroscience

    Homeostatic synaptic plasticity of miniature excitatory postsynaptic currents in mouse cortical cultures requires neuronal Rab3a

    Andrew G Koesters, Mark M Rich, Kathrin Engisch
    The first demonstration that a protein thought to function presynaptically (Rab3a) is required for homeostatic, activity-dependent synaptic plasticity of quantal size in central neurons.
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Magazine

    1. Neuroscience

    Primate Research: Probing the staying power of chemogenetics

    Maria Puchik, Igor Kagan
    1. Genetics and Genomics
    2. Neuroscience

    Aging: Unlocking the longevity code with stress

    Loren Cocciolone, Valeria Uvarova, Patricija van Oosten-Hawle
    1. Developmental Biology

    Blastomeres: Tracing cell fates in embryos

    Ying Zhang, Qi Chen
    1. Cancer Biology

    Transcription Factor-Dependent Cancers: Targeting chromatin remodeling complexes to treat uveal melanoma

    Jonas A Nilsson
    1. Structural Biology and Molecular Biophysics

    Enzyme Dynamics: Capturing enzymes in motion

    Álvaro de la Gándara, Agnieszka A Kendrick

  6. Living Science: My grandmother’s rug

    Eve Marder
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Wnt Signaling: Exploring the origins of a signaling pathway

    Balaji Santhanam
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
  16. Plant Biology
  17. Stem Cells and Regenerative Medicine
  18. Structural Biology and Molecular Biophysics
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