Highlights
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Closing the neural tube
High-throughput arrayed CRISPR interference screening of organoid models gives insight into genetic regulators of neural tube closure in humans.
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Evolution in eutherian mammals
Following the end-Cretaceous extinction, eutherian mammals in China evolved larger teeth before developing more specialised biting adaptations.
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Insights into synaptic dysfunction
LRRK2, a protein linked to Parkinson’s disease, interacts with an actin-binding protein, drebrin, to regulate synaptic function and has a role in BDNF-dependent synaptic modulation.
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Publish-review-curate at eLife
eLife is rethinking how research is reviewed and published.
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Modulating hyperexcitability
PRRT2, a transmembrane protein, helps to limit neuronal hyperexcitability by modulating slow inactivation of voltage-gated sodium channels.
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Science under threat
How should the scientific community respond to ideological attacks on science?
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.
Patrick Allard, UCLA and eLife author
Researchers explain why they published in eLifeMagazine
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