Highlights

  • The safety-efficiency dilemma

    The Pavlovian fear system has a larger role in decision-making than previously thought, helping to keep it both safe and efficient during exploratory behaviour.

    Pranav Mahajan, Shuangyi Tong ... Ben Seymour
    Research Article
  • New university partnerships

    eLife is partnering with two leading UK universities on open access agreements that promote a more open and equitable approach to scientific publishing.

    Press Pack
  • Inside a thylakoid membrane

    The molecular architecture of the thylakoid membrane in a vascular plant has been determined with single-molecule precision.

    Wojciech Wietrzynski, Lorenz Lamm ... Benjamin D Engel
    Research Advance
  • Enzyme production in fungi

    The secretion of enzymes by A. oryzae, a filamentous fungus with multiple nuclei that is widely used in food production, increases with cell volume and nuclear number.

    Ayaka Itani, Haruto Motomura ... Norio Takeshita
    Research Article
  • The benefits of disorder

    The presence of an intrinsically disordered region in a transcription factor enhances both target binding and search efficiency.

    Wencheng Ji, Ori Hachmo ... Ariel Amir
    Research Article
  • Tracing cell fates in embryos

    Differences in the activity of an enzyme called CARM1 influence whether blastomeres become part of the embryo or the placenta.

    Ying Zhang, Qi Chen
    Insight

Latest research

    1. Physics of Living Systems

    The Matthew effect and early-career setbacks in research funding—a replication study

    Vincent Traag, Emer Brady ... Carter Bloch
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience
    2. Computational and Systems Biology

    Absence of Systematic Effects of Internalizing Psychopathology on Learning Under Uncertainty

    Muhammad H Satti, Katharina Wille ... Rasmus Bruckner
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cell Biology

    Organelle membrane-associated proteins recruit cGAS via phase separation to facilitate its membrane localization

    Chengrui Shi, Chaofei Su ... Hang Yin
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Neuroscience

    Distinct cortical encoding of acoustic and electrical cochlear stimulation

    Ariel Edward Hight, Michele N Insanally ... Robert C Froemke
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Genetics and Genomics

    Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment

    Nicholas Tolman, Taibo Li ... Simon WM John
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Computational and Systems Biology

    A network regularized linear model to infer spatial expression pattern for single cell

    Chaohao Gu, Hu Chen, Zhandong Liu
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Convincing
    1. Neuroscience

    Frequency and Laminar Profile of Feature Specific Visual Activity Revealed by Interleaved EEG-fMRI

    Tommy Clausner, José P Marques ... Mathilde Bonnefond
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cell Biology
    2. Neuroscience

    Death receptor 6 does not regulate axon degeneration and Schwann cell injury responses during Wallerian degeneration

    Bogdan Beirowski, Haoran Huang, Elisabetta Babetto
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Active regulation of the epidermal growth factor receptor by the membrane bilayer

    Shwetha Srinivasan, Xingcheng Lin ... Gabriela S Schlau-Cohen
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing