Highlights

  • Closing the neural tube

    High-throughput arrayed CRISPR interference screening of organoid models gives insight into genetic regulators of neural tube closure in humans.

    Roya E Huang, Giridhar M Anand ... Sharad Ramanathan
    Research Article

  • Pikas power yak pastures

    Plateau pikas play a role in enhancing weight gains in yaks, by suppressing toxic plants and improving the availability and quality of palatable forage.

    Zhiwei Zhong, Bingbo Ni ... Zhibin Zhang
    Reviewed Preprint Updated

  • Re-evolving traits

    Hybridization chain reaction and confocal imaging reveal latent ocelli gene regulatory network expression in ant workers, with a role in partial re-evolution of caste-specific traits.

    Angelly Vasquez-Correa, Johanna Arnet ... Ehab Abouheif
    Research Article

  • Publish-review-curate at eLife

    eLife is rethinking how research is reviewed and published.

    Timothy E Behrens, Yamini Dalal, Diane M Harper
    Editorial

  • AI in research communication

    eLife has partnered on a number of projects harnessing AI for improving human and machine reader engagement with research.

    Inside eLife

  • Science under threat

    How should the scientific community respond to ideological attacks on science?

    Humberto J Debat
    Feature Article
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Cell Biology

    SETD6-mediated methylation of PPARγ establishes a transcriptional feedback circuit promoting lipid accumulation in liver-derived cells

    Noa Nashnaz, Dana Goldberg ... Dan Levy
    SETD6-mediated methylation of PPARγ establishes a positive feedback mechanism that enhances transcriptional activation and promotes hepatic lipid accumulation.
    1. Neuroscience

    Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation

    Sofie S Jacobsen, Allison B Morehouse ... Celia Kjaerby
    Very-low-frequency heart rate variability reflects locus coeruleus activity during sleep and predicts spindle-dependent memory consolidation across mice and humans.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Pre-Cambrian origin of envelope-carrying retrotransposons in metazoans

    Shashank Chary, Rippei Hayashi
    Envelope-carrying Ty3/gypsy LTR retrotransposons are ancient and widespread across animals, revealing deep evolutionary links between retroelements, viral fusogens, and retroviruses.
    1. Neuroscience

    Dynamic fMRI networks of human emotion

    Niels Janssen, Uriel KA Elvira ... Theo GM van Erp
    Time-resolved mapping of whole-brain functional MRI networks during human emotional experience reveals a dynamic systems-level organization that links temporal processing with large-scale functional brain architecture.
    1. Epidemiology and Global Health

    Understanding pain in women with polyendocrine metabolic ovarian syndrome: health risks and treatment effectiveness

    Tess Cherlin, Stephanie Mohammed ... Shefali Setia Verma
    Pain affects one in five women with PMOS, with pronounced racial disparities and meaningful reduction following targeted medical treatment.
    1. Genetics and Genomics

    Systematic cross-study assessment of RNA-Seq experimental workflows for plasma cell-free transcriptome profiling

    Cristina Tuñí-Domínguez, Giovanni Asole ... Julien Lagarde
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Genetics and Genomics

    Genomic variation and ancestry of Helicobacter pylori in the admixed population of Cabo Verde reveal host adaptation, limited host–pathogen ancestry concordance, and signatures of trans-Atlantic slave trade migrations

    Timothy Archampong, Yi Ling Tam ... Sandra Beleza
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Multi-timescale dynamics organize descending pain modulation

    Carl Ashworth, Melissa Martenson ... Flavia Mancini
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Ecology

    Monkey hear, monkey do what? An application of Automated Behavioural Response systems for hypothesis testing in the world’s smallest monkey

    Larissa Barker, Sarah Papworth
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Prenatal Alcohol Exposure Disrupts γ-Secretase Activity and Impairs Learning and Memory in Wild-Type and 3xTg-AD Mice

    Paola Montenegro, Rachel Kim ... Hermes Yeh
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
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Magazine

  1. Point of View: Scientific writing is not a murder mystery

    Charlotte A Dodson
    1. Neuroscience

    Visual Categorization: How monkeys carve up the visual world

    Binxu Wang
    1. Cell Biology

    Stress: How to give cells an identity crisis

    Paige Dillon, Julie Hollien
    1. Epidemiology and Global Health

    Malaria Prevention: Using mathematical models to optimise mosquito net distribution

    Carlos A Prete Jr
    1. Plant Biology

    Mixotrophy: An updated view of glucose pathways in cyanobacteria

    José Manuel García-Fernández
  6. Mountain gorilla

    Episode 104: July 2026

    1. Cell Biology
    2. Developmental Biology

    Organ Development: Following your heart as it takes shape

    Alexandra Trouilloud, Nicole C Dubois
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
  16. Physiology
  17. Plant Biology
  18. Stem Cells and Regenerative Medicine
  19. Structural Biology and Molecular Biophysics
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