All research categories

Highlights

  • Deep mutational scanning

    High-resolution approach has been used to assess the effect of more than 6000 protein-coding variants in a G protein-coupled receptor associated with obesity.

    Conor J Howard, Nathan S Abell ... Nathan B Lubock
    Reviewed Preprint Updated

  • eLife wins award for UX

    eLife wins user experience (UX) award from OpenAthens for its user-driven approach to the design of Reviewed Preprints.

    Press Pack

  • eLife Community Ambassadors

    Over 100 early-career researchers from around the world have joined scheme to create change across the global research community.

    Inside eLife

Latest research

    1. Microbiology and Infectious Disease
    2. Ecology

    Effects of parental care on skin microbial community composition in poison frogs

    Marie-Therese Fischer, Katherine S Xue ... Lauren A O’Connell
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Neuroscience

    Minimal background noise enhances neural speech tracking: Evidence of stochastic resonance

    Björn Herrmann
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Evolutionary Biology

    Social and environmental predictors of gut microbiome age in wild baboons

    Mauna R Dasari, Kimberly E Roche ... Elizabeth A Archie
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    MLCK/MLCP regulates mammalian axon regeneration and redistributes the growth cone F-actin

    Saijilafu, Wei-Hua Wang ... Yan-Xia Ma
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Microbiology and Infectious Disease

    Amidase and lysozyme dual functions in TseP reveal a new family of chimeric effectors in the type VI secretion system

    Zeng-Hang Wang, Ying An ... Tao Dong
    Structural and functional analyses identify a new family of bifunctional cell-wall-targeting type VI secretion system (T6SS) effectors and a surface-charge-engineering strategy that expands T6SS activity against Gram-positive cells.
    1. Developmental Biology

    Single-nucleus multiomics reveals the gene regulatory networks underlying sex determination of murine primordial germ cells

    Adriana K Alexander, Karina F Rodriguez ... Humphrey HC Yao
    Single-cell multiomic analyses reveal known and new genes and pathways involved in the development of germ cells and provide a discovery platform for the scientific community.
    1. Neuroscience

    Aminergic and peptidergic modulation of insulin-producing cells in Drosophila

    Martina Held, Rituja S Bisen ... Jan M Ache
    The combination of receptor expression analysis, optogenetics, physiological approaches, and connectomics reveals how a heterogeneous population of insulin-producing cells in Drosophila integrates diverse modulatory inputs to adjust insulin release.
    1. Neuroscience

    Dopamine increases protein synthesis in hippocampal neurons enabling dopamine-dependent LTP

    Tanja Fuchsberger, Imogen Stockwell ... Ole Paulsen
    The reward signal dopamine modulates synaptic plasticity by increasing protein synthesis, revealing a potential molecular mechanism for long-term memory storage.
    1. Developmental Biology

    The asymmetric expression of HSPA2 in blastomeres governs the first embryonic cell-fate decision

    Jiayin Gao, Jiawei Wang ... Keliang Wu
    HSPA2 as a critical early regulator of the first cell-fate decision in mammalian embryos.
    1. Neuroscience

    Cross-modal interaction of Alpha Activity does not reflect inhibition of early sensory processing: A frequency tagging study using EEG and MEG

    Marion Brickwedde, Rupali Limachya ... Ali Mazaheri
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
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Magazine

    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Cellular Energy Production: Mycofactocin and the mycobacterial electron transport chain

    Stephanie M Stuteley, Ghader Bashiri
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Transcription: The plusses and minuses of DNA torsion

    Steven Henikoff, David L Levens

  3. Episode 97: February 2025

    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Neurodegeneration: A role for RNA knots in Alzheimer’s disease

    Silvia Galli, Marco Di Antonio
    1. Developmental Biology

    Morphogenesis: Fluid transport comes to the fore

    Yufei Wu, Sean X Sun
    1. Developmental Biology
    2. Neuroscience

    Axon Guidance: Watching axons on the move

    Maria I Lazaro-Pena, Carlos A Diaz-Balzac
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Drug Discovery: How to exploit the recycling system of a cell

    Sasha L Evans, Bethany A Haynes ... Rivka L Isaacson
  8. See more Magazine articles

Research categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
  16. Plant Biology
  17. Stem Cells and Regenerative Medicine
  18. Structural Biology and Molecular Biophysics
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