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A novel high-throughput, whole organism chemical screening platform was used to identify existing drugs that increase pancreatic beta-cell mass in zebrafish, implicating unique roles for the NF-κB and serotonergic signaling pathways in regulating pancreatic biology.
Guangliang Wang, Surendra K Rajpurohit, Fabien Delaspre, Steven L Walker, David T White, Alexis Ceasrine, Rejji Kuruvilla, Ruo-jing Li, Joong S Shim, Jun O Liu, Michael J Parsons, Jeff S Mumm
10.7554/eLife.08261
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Fish trace amine-associated receptors evolved a novel structural motif that enables the detection of chemically diverse amine odors in a non-canonical 'inverted' orientation.
Qian Li, Yaw Tachie-Baffour, Zhikai Liu, Maude W Baldwin, Andrew C Kruse, Stephen D Liberles
10.7554/eLife.10441
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C. elegans germline stem cells become quiescent under starved conditions, and this quiescence maintains the stem cell state even in the absence of GLP-1/Notch signaling, which is otherwise essential for stem cell maintenance.
Hannah S Seidel, Judith Kimble
10.7554/eLife.10832
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A transcriptome-based metric for aging reveals a longevity mechanism that specifically prolongs the duration of young adulthood rather than slowing overall aging.
Sunitha Rangaraju, Gregory M Solis, Ryan C Thompson, Rafael L Gomez-Amaro, Leo Kurian, Sandra E Encalada, Alexander B Niculescu III, Daniel R Salomon, Michael Petrascheck
10.7554/eLife.08833
Primary and higher order visual area dimensions in the neocortex are determined by the same genetic mechanisms during development which in turn also control the proportionate scaling between them.
Andreas Zembrzycki, Adam M Stocker, Axel Leingärtner, Setsuko Sahara, Shen-Ju Chou, Valery Kalatsky, Scott R May, Michael P Stryker, Dennis DM O'Leary
10.7554/eLife.11416
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Building on previous work (Kaneko and Stryker, 2014), we report that the specific population of inhibitory neurons that increases the responses of neurons in the visual cortex during locomotion will also, when activated or blocked artificially, dramatically alter adult cortical plasticity, revealing that the aerobic exercise of locomotion is not necessary.
Yu Fu, Megumi Kaneko, Yunshuo Tang, Arturo Alvarez-Buylla, Michael P Stryker
10.7554/eLife.05558
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