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A combination of advanced optical imaging and cryogenic electron microscopy has been used to explore membrane fusion in a synthetic system and provide new insights into neurotransmitter release.
Jiajie Diao, Patricia Grob, Daniel J Cipriano, Minjoung Kyoung, Yunxiang Zhang, Sachi Shah, Amie Nguyen, Mark Padolina, Ankita Srivastava, Marija Vrljic, Ankita Shah, Eva Nogales, Steven Chu, Axel T Brunger
10.7554/eLife.00109
Optogenetic techniques, whereby light is used to activate neuronal cells, are quickly becoming widely used in neuroscience; but excessive exposure to light can actually silence certain types of neuronal cells.
Alexander M Herman, Longwen Huang, Dona K Murphey, Isabella Garcia, Benjamin R Arenkiel
10.7554/eLife.01481
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