Leadership team

The working scientists who serve as eLife editors, our early-career advisors, governing board, and our executive staff all work in concert to realise eLife’s mission to accelerate discovery.

Editor-in-Chief

  1. Mike Eisen

    Michael B Eisen

    HHMI, University of California, Berkeley, United States

    Michael Eisen majored in math as an undergraduate at Harvard, exploiting the department’s lack of interest in what students did outside of the field to pursue his true love of ecology and evolutionary biology. Trying to unite his quantitative side with his interest in biology, he entered the Harvard Graduate Program in Biophysics, completing his PhD with Don Wiley, using X-ray crystallography to study the evolution of influenza virus proteins.

    After a stint as the play-by-play voice of the Columbia (Tennessee) Mules Professional Baseball Club, he joined the labs of Pat Brown and David Botstein at Stanford at the dawn of the era of functional genomics, where he played multiple roles in the development of DNA microarrays as a tool for studying biology. His most notable contribution was a 1998 paper showing how clustering methods can reveal underlying biological structure in genomic data that helped to establish many analytical paradigms in genomics.

    He began his independent career at Lawrence Berkeley National Lab, before moving to the Department of Molecular and Cell Biology at UC Berkeley. In addition to the main focus of his lab – using experimental, computational and evolutionary methods to study spatial patterns of gene regulation in the early Drosophila embryo – he has a longstanding interest in understanding the molecular basis for the varied microorganisms that have evolved to manipulate animal behavior.

    Outside of the lab, he has been a fervent and occasionally strident advocate for opening up the system of scholarly publishing, founding, along with Brown and Harold Varmus, the Public Library of Science (PLOS). More recently he has dabbled in politics and serves as an advisor to Impossible Foods, a company Brown started to create plant-based meats to end the planetary scourge of animal farming.

    Expertise
    Developmental Biology
    Genetics and Genomics
    Research focus
    development
    genomics
    embryogenesis
    computational biology
    Experimental organism
    D. melanogaster
    Competing interests statement
    Impossible Foods: I am an advisor to Impossible Foods, a company founded by my former postdoctoral advisor Patrick Brown, to develop plant-based alternatives to foods derived from animal projects. I got involved in the company because animal farming has a massively negative effect on the planet, and because I believe we can reduce this negative impact by offering consumers products that satisfy their desire for meat, cheese and other dairy products that have less of an impact on the environment. I spend time on the company because I believe deeply in its mission, but I also receive a small stipend for my work and own equity. 23andMe: I used to serve on the Scientific Advisory Board of 23andMe, a company that provides consumers with information on their DNA through genotyping and through a website that offers information on ancestry and ties the unique collection of DNA variants they contain to the emerging scientific literature on the effect of these mutation. I do not hold any equity in the company, but I support their mission and my long affiliation with them may constitute a conflict of interest. Public Library of Science: For 20 years I have been a public advocate for reforming the way scientists communicate, and much of my work in this domain focused on the Public Library of Science, a non-profit publisher of open-access scientific and medical journals on whose board of directors I served from 2002–18. My work for PLOS was strictly on a volunteer basis: at no point did I receive any compensation from the company for my role. Despite having no financial interest in PLOS, I have put a huge amount of blood, sweat and tears into the company. I believe fervently in its mission and have an obvious personal stake in its success, even though I am no longer affiliated with them. Science funding: As a working scientist who has received grants from a variety of government funding agencies, I have a professional interest in promoting science funding and in influencing the way research funds are distributed. Anyone who follows me knows that I speak my mind freely on the NIH and other funding agencies and their problems, but I will admit that I used to pull my punches occasionally for fear that it would influence my prospects of funding. I currently receive virtually all of my lab’s funding from the Howard Hughes Medical Institute, and thus I clearly have a professional conflict when talking about HHMI. Institutional: I work at the University of California, Berkeley, and have an institutional conflict of interest on anything dealing with UCB, with the University of California writ large, educational funding in California, and, arguably, public higher education policy at the national and state level. I also have a conflict of interest when talking about areas where UC, UCB or my department (Molecular and Cell Biology) have a financial interest, especially on patents. This is currently most relevant in regards to the patent interference case being contested by Berkeley, MIT and others over CRISPR technology. (Modified from “My Conflicts of Interest” at michaeleisen.org/blog.)

Deputy editors

  1. Anna Akhmanova

    Anna Akhmanova

    Utrecht University, Netherlands

    Anna Akhmanova is a Professor of Cell Biology at the Department of Biology, Faculty of Science, Utrecht University, the Netherlands. She studied biochemistry and molecular biology at the Moscow State University and obtained her PhD at the University of Nijmegen, the Netherlands. Akhmanova studies cytoskeletal organization and trafficking processes, which contribute to cell polarization, differentiation, vertebrate development and human disease. The main focus of the work in her group is the microtubule cytoskeleton. Research in the group relies on combining high-resolution live cell imaging and quantitative analysis of cytoskeletal dynamics with in vitro reconstitution experiments. Her work has resulted in identification and characterization of a broad variety of factors which control microtubule organization and dynamics and motor attachment to membrane organelles. Anna Akhmanova is an elected member of the European Molecular Biology Organization and the Royal Netherlands Academy of Arts and Sciences.

    Expertise
    Cell Biology
    Research focus
    cytoskeletal dynamics
    microtubule-binding proteins
    microtubule-based motors
    membrane transport
    Competing interests statement
    Anna Akhmanova receives funding from the European Research Council, Human Frontier Science Program, and the Netherlands Organization for Scientific Research. She is a member of the Scientific Advisory Board of the Netherlands Institute for Neuroscience. She served on the editorial boards of BMC Cell Biology and Journal of Biological Chemistry. She is a currently on the editorial boards of PLOS Biology, Journal of Cell Science, Traffic, and BioArchitecture.
  2. Eve Marder

    Eve Marder

    Brandeis University, United States

    Eve Marder is the Victor and Gwendolyn Beinfield Professor of Neuroscience at Brandeis University. Marder is a Past President of the Society for Neuroscience (SfN). Marder is a member of the National Academy of Sciences, the Institute of Medicine, the American Academy of Arts and Sciences, and a Fellow of the Biophysical Society, the American Association for the Advancement of Science, and the International Society of Neuroethology. She received the Miriam Salpeter Award from WIN, the WF Gerard Prize from the SfN, the Miller Prize from the Society for Cognitive Neuroscience, the Karl Spenser Lashley Prize from the American Philosophical Society, and the Gruber Prize in Neuroscience. Marder served on the NIH BRAIN Initiative working group. Marder studies the dynamics of small neuronal networks, and her work was instrumental in demonstrating that neuronal circuits are not "hard-wired" but are reconfigured by neuromodulators to produce a variety of outputs. She now studies the extent to which similar network performance can arise from different sets of network parameters.

    Expertise
    Neuroscience
    Research focus
    systems neuroscience
    neurobiology
    central pattern generators
    neuromodulation
    homeostasis
    circuit dynamics
    neuronal excitability
    computational models of neuronal dynamics
    Competing interests statement
    Eve Marder is employed by Brandeis University. She receives research and training funding from the National Institutes of Health, the Leir Foundation, and the Swartz Foundation. She serves on the Scientific Advisory Board of Janelia Farm. She is a member of the National Academy of Sciences, the American Academy of Arts and Sciences, a Fellow of the American Association of Science, and a Fellow of the Biophysical Society. She presently serves on editorial boards of Current Biology, Current Opinion in Neurobiology, and Progress in Neurobiology.
  3. Detlef Weigel

    Max Planck Institute for Developmental Biology, Germany

    Detlef Weigel received his PhD in 1988 from the Max Planck Institute for Developmental Biology. After postdoctoral work at the California Institute of Technology, he joined the faculty of the Salk Institute in 1993. Since 2002, he has been director of the Department of Molecular Biology at the Max Planck Institute for Developmental Biology. His current research interests focus on natural genetic variation and evolutionary genomics of plants. Examples of recent important projects are the 1001 Genomes project for Arabidopsis thaliana, and the systematic dissection of deleterious epistasis between Arabidopsis strains due to autoimmunity. Among the awards he has received are the Young Investigator Award of the National Science Foundation, the Gottfried Wilhelm Leibniz Award of the Deutsche Forschungsgemeinschaft, and the Otto Bayer Award. He is a member of the US National Academy of Sciences, the German National Academy of Sciences Leopoldina and the Royal Society.

    Expertise
    Plant Biology
    Genetics and Genomics
    Evolutionary Biology
    Research focus
    natural variation
    epigenetics
    evolutionary genomics
    plant biology
    genomics
    evolutionary biology
    immunity
    Experimental organism
    A. thaliana
    Competing interests statement
    Detlef Weigel has received funding from the Max Planck Society, the Deutsche Forschungsgemeinschaft, the Foundation of the State of Baden-Württemberg, the German Ministry for Education and Research, the European Commission, the Human Frontiers Science Program Organization, and several US Federal agencies. He serves on the Editorial Boards of Annual Review of Cell and Developmental Biology and Genome Biology. He is Chair of EMBO Council, and is serving or has recently served on the Advisory Boards of the Epigenomics of Plants International Consortium, Bayer Crop Science, The Arabidopsis Information Resource, Flanders Institute of Biotechnology, Temasek Life Sciences Laboratory, and the Sainsbury Laboratory. He is a co-founder of Computomics and CeMet.

Senior editors

  1. Richard Aldrich

    Richard Aldrich

    The University of Texas at Austin, United States

    Rick Aldrich is the Karl Folkers Chair II in Interdisciplinary Biomedical Research and Professor of Neuroscience at The University of Texas at Austin. He joined the faculty in 2006 and served as chair until 2011. Previously he was on the faculty of Neurobiology (1985-1990) and of Molecular and Cellular Physiology (1990-2006) at Stanford University where he served as department chair from 2001–2004. He was an investigator with the Howard Hughes Medical Institute from 1990 to 2006. His work is on molecular mechanisms of ion channels and calcium signaling proteins, with an emphasis on understanding gated conformational changes and allosteric mechanisms. Work in the laboratory is multidisciplinary including electrophysiology, biochemistry, spectroscopy, informatics and computation. He is a member of the National Academy of Science and the American Academy of Arts and Sciences, and is a Fellow of the American Association for the Advancement of Science and of the Biophysical Society. He is past president of the Biophysical Society and the Society of General Physiologists, and has received the Kenneth Cole Award for Membrane Physiology from the Biophysical Society and Alden Spencer Award for Neuroscience Research from Columbia University.

    Expertise
    Structural Biology and Molecular Biophysics
    Neuroscience
    Research focus
    ion channels
    calcium binding proteins
    membrane transport
    allostery and cooperativity
    cellular neurophysiology
    biochemical neuroscience
    Competing interests statement
    Richard Aldrich is employed by The University of Texas at Austin. He receives research funding from the National Institutes of Health. He is a member of the National Academy of Science and the American Academy of Arts and Sciences, and is a Fellow of the American Association for the Advancement of Science and of the Biophysical Society. He serves actively on the editorial boards of Proceedings of the National Academy of Sciences and The Journal of General Physiology.
  2. Ian Baldwin

    Ian Baldwin

    Max Planck Institute for Chemical Ecology, Germany

    Ian Baldwin studied biology and chemistry at Dartmouth College in Hanover, New Hampshire and graduated 1981 with an AB. In 1989, he received a PhD in Chemical Ecology from Cornell University, in the Section of Neurobiology and Behavior. He was an Assistant (1989), Associate (1993) and Full Professor (1996) in the Department of Biology at SUNY Buffalo. In 1996 he became the Founding Director of the Max Planck Institute for Chemical Ecology, where he now heads of the Department of Molecular Ecology. In 1999 he was appointed Honorary Professor at Friedrich Schiller University in Jena, Germany. In 2002 he founded the International Max Planck Research School at the Max Planck Institute in Jena. Baldwin's scientific work is devoted to understanding the traits that allow plants to survive in the real world. To achieve this, he has developed a molecular toolbox for the native tobacco, Nicotiana attenuata (coyote tobacco) and a graduate program that trains “genome-enabled field biologists” to combine genomic and molecular genetic tools with field work to understand the genes that matter for plant-herbivore, -pollinator, -plant, -microbial interactions under real-world conditions. He has also been a driver behind the open-access publication efforts of the Max Planck Society.

    Expertise
    Ecology
    Evolutionary Biology
    Plant Biology
    Research focus
    evolutionary biology
    plant biology
    evolution and ecology
    secondary metabolism
    organismic level gene function
    Competing interests statement
    Ian Baldwin has received funding from the Max Planck Society, the Deutsche Forschungsgemeinschaft, the US National Science Foundation, the AW Mellon Foundation, the European Research Council, and the Human Frontiers Science Program Organization. He currently serves on the editorial board of The Journal of Integrated Plant Biology; and previously, Oecologia, Ecological Studies Series, Chemoecology, and The Plant Journal. He serves on the advisory boards of the Copenhagen Plant Science Centre, Lytle Preserve, Brigham Young University, and more MPG programs than can be listed; and previously, the Institute of the Chemistry and Dynamics of the Geosphere, Jülich, the Minerva Center for Arid Ecosystems Research, Hebrew University, the Wissenschaftskolleg, Berlin, the Swiss NSF Priority Program "Plant Survival in Natural and Agricultural Ecosystems”, and the DFG Priority Programs "Biological radiations" and "Trophic interactions and dynamics of communities".
  3. Utpal Banerjee

    University of California, Los Angeles, United States

    Utpal Banerjee is the Irving and Jean Stone Professor and Chair of the Department of Molecular, Cell and Developmental Biology at the University of California, Los Angeles, with a joint appointment in the Department of Biological Chemistry at the David Geffen School of Medicine. He also serves as Co-Director of the Broad Stem Cell Research Center and as Director of the UCLA Interdepartmental Minor in Biomedical Research. He is a member of UCLA’s Jonsson Comprehensive Cancer Center and is affiliated with the Brain Research Institute and the Neuroscience Graduate Program.

    Banerjee’s laboratory has worked on several oncogenic and metabolic signals that are important in development and disease. The lab studies the effects of systemic signals on the maintenance of blood progenitors in Drosophila, and the role of metabolic pathways in the control of proliferation and differentiation in the preimplantation mouse embryo.

    Expertise
    Developmental Biology
    Stem Cells and Regenerative Medicine
    Cancer Biology
    Research focus
    haematopoiesis
    cancer biology
    Experimental organism
    D. melanogaster
    mouse
  4. Naama Barkai

    Naama Barkai

    Weizmann Institute of Science, Israel

    Naama Barkai is a systems and computational biologist interested in how bio-molecular circuits are designed. She joined the Weizmann Institute in 1999, following a post-doc (Princeton) and graduate studies (Hebrew University) in physics. She is currently chair of the Department of Molecular Genetics, and the head of the Azrieli and Kahan Centers for Systems Biology at the Weizmann Institute. In 2013, Barkai was elected to a Vallee Foundation Visiting Professorship and awarded the Abisch Frankel prize.

    Expertise
    Computational and Systems Biology
    Physics of Living Systems
    Genetics and Genomics
    Research focus
    systems biology
    modeling
    functional genomics
    yeast genetics
    morphogen gradients
    Competing interests statement
    Naama Barkai's main funding sources are from the European Research Council (ERC), the Human Frontier Science Program (HFSP), the Israel Science Foundation (ISF), Minerva, and the Bi-national Science Foundation (BSF). Barkai also serves on the editorial board of Development.
  5. Timothy Behrens

    Timothy Behrens

    University of Oxford, United Kingdom

    Tim Behrens is Professor of Computational Neuroscience at Oxford University and University College London, and a Wellcome Trust Senior Research Fellow. His work investigating the neural mechanisms that control behaviour has made an impact across scales from cells to brain regions across mammalian species. He has also developed widely used approaches for measuring brain connections non-invasively that have been taken up by the Human Connectome Project, where he is a senior investigator and chair of the anatomical connectivity team.

    Expertise
    Neuroscience
    Research focus
    brain imaging
    fMRI
    learning
    cognition
    behavioural neuroscience
    learning and decision making
    brain connectivity
    computational neuroscience
    neural coding
    Experimental organism
    macaque
    Competing interests statement
    Tim Behrens receives funding from the Wellcome Trust, the James S McDonnell Foundation, the National Institute of Health, and the UK Engineering and Physical Sciences Research Council. He is on the editorial board of PLOS Biology.
  6. Olga Boudker

    Weill Cornell Medicine, United States

    Olga Boudker is an Associate Professor of Physiology and Biophysics at Weill Cornell Medicine and a Howard Hughes Medical Institute Investigator. Boudker's lab uses crystallography and cryo-EM to define the high-resolution structures of key functional states of transporters; single molecule FRET TIRF microscopy and NMR to probe their dynamics; biochemical approaches and isothermal titration calorimetry to probe their function and energetics; and bioinformatics to follow their evolution.

    Expertise
    Structural Biology and Molecular Biophysics
    Neuroscience
    Research focus
    membrane transporters
    membrane biology
    glutamate pumps
    membrane protein structure and function
    x-ray crystallography
  7. Marianne E Bronner

    Marianne E Bronner

    California Institute of Technology, United States

    Marianne Bronner is a developmental biologist with a long-standing interest in specification, migration and differentiation of neural crest stem cells. Using a pan-vertebrate approach, her lab has been systematically studying the gene regulatory network responsible for neural crest formation and evolutionary origin. Born in Budapest, Hungary, Marianne’s family escaped to Austria during the Hungarian revolution when she was a small child. She received her ScB in Biophysics from Brown University and then a PhD in Biophysics from Johns Hopkins University. She assumed her first faculty position at the University of California, Irvine, before moving to Caltech in 1996. Marianne received the Conklin Medal from The Society for Developmental Biology in 2013, the Women in Cell Biology Senior Award from the American Society for Cell Biology in 2012, as well as several teaching awards from her institution. She was elected to American Academy of Arts and Sciences in 2009 and the National Academy of Sciences in 2015.

    Expertise
    Developmental Biology
    Stem Cells and Regenerative Medicine
    Research focus
    neural crest
    peripheral nervous system
    placodes
    developmental neurobiology
    vertebrate development biology
    cell lineage
    cell migration
    vertebrate evolution
    Experimental organism
    chick
    lamprey
    zebrafish
    Xenopus
    Competing interests statement
    Marianne Bronner is employed by the California Institute of Technology and receives research funding from the National Institutes of Health. She is on the board of the International Society for Stem Cell Research, and member of several other societies (e.g., Society for Developmental Biology, the American Society for Cell Biology, Society for Neuroscience, International Society for Differentiation). In addition to being a Senior Editor for eLife, she is Editor-in-Chief of Developmental Biology and serves actively as monitoring editor of Journal of Cell Biology, Molecular Biology of the Cell, PLOS Biology and PNAS. She is presently on the boards of the Sontag Foundation and Curci Foundation as well as the Conference Evaluation Committee of the Gordon Research Conferences.
  8. Christian Büchel

    University Medical Center Hamburg-Eppendorf, Germany

    Christian Büchel is a member of the Hamburg Center for Neuroscience in Hamburg, where he is also the Director of the Department for Systems Neuroscience at Hamburg University Medical Center. He holds an Affiliate Professor appointment in the Psychology department at the University of Hamburg. After Medical School at the University of Heidelberg, he performed postdoctoral research with Karl Friston as a Wellcome Research Fellow at the Wellcome Department of Imaging Neuroscience at UCL in London with a focus on effective connectivity.

    Establishing his lab in Hamburg, he focused on the cognitive neuroscience of pain and motivation and initially studied decision making with an emphasis on delay discounting. In a parallel stream of projects he observed that the pain modulation underlying placebo analgesia can already be observed at the spinal cord level, a finding which he later also established for nocebo hyperalgesia. He is part of the IMAGEN study and during his time at Stanford he identified hypoactivation of reward circuits as a potential risk factor for addiction.

    He is a member of the Academy of Science in Hamburg and was awarded the Jung Award for Medicine, the Gottfried Wilhelm Leibniz-Preis by the German Research Foundation, and the Wiley Young Investigator Award of the Organization for Human Brain Mapping for recognition of his work in cognitive neuroscience.

    Expertise
    Neuroscience
    Research focus
    cognitive neuroscience
    pain modulation
    decision-making
    fear and anxiety
    addiction
    Experimental organism
    human
    Competing interests statement
    Christian Büchel has received research grants from the European Research Council, Deutsche Forschungsgemeinschaft and Bundesministerium für Bildung und Forschung. He serves on the board of reviewing editors of Science magazine. He serves on the Swiss National Research Council, the Scientific Advisory Board of the ICM in Paris and the Center for Behavioral Brain Sciences, Magdeburg, Germany.
  9. Ronald L Calabrese

    Emory University, United States

    Ron Calabrese earned his BS in Biochemistry from Cornell University and a PhD in Neurobiology from Stanford University. He has been on the Faculty of the Department of Biology, Emory University since 1986 and is currently the Samuel Candler Dobbs Professor of Biology and Senior Associate Dean for Research. Calabrese's research focuses on the cellular mechanisms of motor control by central pattern generator (CPG) networks and the importance and implications of individual variation for network function and motor performance. His group uses an invertebrate model system, leeches, and focuses on the CPG that controls the beating of the animals two coordinated hearts. His research closely integrates electrophysiological experiments and computational modeling. They are particularly excited about their discovery, in collaboration with GS Cymbalyuk, that the Na/K pump current contributes to the bursting dynamics of oscillator neurons that pace the CPG, and in their recent eLife publication on output variability across animals and levels in a the leech-heartbeat motor system. Calabrese has been actively engaged in training 12 doctoral students, 2 masters' students, and 22 postdoctoral fellows. In 2017, he received the Award for Education in Neuroscience of the Society for Neuroscience.

    Expertise
    Computational and Systems Biology
    Neuroscience
    Research focus
    motor pattern generation
    neuronal and small networks models
    electrophysiological properties of neurons and synapse
    computational neuroscience
    Experimental organism
    leech
    Competing interests statement
    Over the past 30 years, Ron Calabrese has been consistently supported by NIH R01 grants. Since 2015, Calabrese has been a regular member of the SMI study section of NIH.
  10. Kathryn Cheah

    The University of Hong Kong, Hong Kong SAR China

    Kathryn Cheah is a developmental geneticist and Jimmy & Emily Tang Professor in Molecular Genetics and Chair Professor of Biochemistry at the University of Hong Kong. She received her BSc Hons degree in Biology from the University of London and PhD in Molecular Biology from Cambridge University, U.K. After postdoctoral training at the University of Manchester and Imperial Cancer Research Fund in the UK, she joined the University of Hong Kong. Her research focuses on using functional genomics and mouse models to understand gene function and regulation, the associated gene regulatory networks and mechanisms of disease, with a focus on skeletal and inner ear development, congenital and common skeletal disorders. Notable contributions are the identification of SOX2 as essential for prosensory development in the inner ear, SOX9 as a key regulator of COL2A1 and the cartilage gene regulatory network, a lineage continuum for cartilage and bone cells and a causative mechanistic link between endoplasmic reticulum stress and skeletal disorders. She is an elected Fellow of the Global Science Academy, The World Academy Sciences (TWAS).

    She was the founding President of the Hong Kong Society for Developmental Biology and the Hong Kong representative for the Asia-Pacific Developmental Biology Network and the International Society of Developmental Biology (2004-2013), elected President of the International Society for Matrix Biology (2006-2008), Senior External Fellow of the University of Freiburg Institute of Advanced Studies (2011-2012) and elected member of the Board of Directors of the International Society of Differentiation (2012-2018).

    She brings editorial expertise to eLife having previously served as Associate Editor for Genesis, guest Associate Editor for PLOS Genetics, Asian Editor for Development Growth & Differentiation (2015-2016), editorial board member of Matrix Biology, BioEssays, Annual Reviews of Genomics & Human Genetics, and as Reviewing Editor of eLife.

    Expertise
    Developmental Biology
    Genetics and Genomics
    Research focus
    gene regulation and development
    inherited and degenerative skeletal disorder
    inner ear
    matrix biology
    Experimental organism
    mouse
    human
    Competing interests statement
    Kathryn Cheah receives research funding from the Hong Kong Research Grants Council and the Hong Kong Health and Medical Research Fund. She is serving as a member of Hong Kong’s University Grants Council Biology Panel for the Research Assessment Exercise 2020. She currently also serves on the editorial boards of Scientific Reports, Genesis and Journal of Orthopaedic Research. She is also serving on the Hong Kong Advisory Board of the Gordon Research Conferences (GRC) and the GRC Conference Evaluation Committee.
  11. Philip Cole

    Harvard Medical School, United States

    Phil Cole is Professor of Medicine and Biological Chemistry and Molecular Pharmacology at Harvard Medical School and is a Senior Investigator in the Division of Genetics at Brigham and Women's Hospital. He graduated from Yale University with a B.S. in Chemistry and then spent a year as a Churchill Scholar at the University of Cambridge prior to obtaining M.D. and Ph.D. degrees from Johns Hopkins School of Medicine where he pursued research in bioorganic chemistry. Cole then entered post-doctoral and clinical training at Harvard Medical School and Brigham and Women's Hospital. He subsequently held faculty positions at Rockefeller University and then Johns Hopkins where he was Chair of Pharmacology prior to returning to Harvard in 2017. His research interests are related to the chemical biology of cell signaling and epigenetics. His group has developed and applied methods for protein semisynthesis and small molecule probes for kinases, acyltransferases, deacetylases, and demethylases. His honors include election to the ASCI, fellow of the AAAS, and receipt of an NIH MERIT award.

    Expertise
    Biochemistry and Chemical Biology
    Research focus
    chemical biology
    signal transduction
    epigenetics
    Competing interests statement
    Philip Cole is on the Scientific Advisory Boards of Memorial Sloan-Kettering Cancer Center, the Maryland Institute of Bioscience and Biotechnology Research, and the Searle Scholars Program. He is a cofounder of Acylin Therapeutics Inc and a science advisor for the Abbvie, Epizyme, and Forma companies and has been a consultant for MPM Capital. Cole has received research funding from the NIH, the FAMRI foundation, and the V Foundation. He is a member of the editorial boards of the following journals: J Biol Chem, Biomed Central Biology, ChemBioChem, and Bioorganic Chemistry.
  12. Laura Colgin

    The University of Texas at Austin, Center for Learning and Memory, United States

    Laura Colgin is an Associate Professor in the Department of Neuroscience and co-Director of the Center for Learning and Memory at the University of Texas at Austin. Her research focuses on understanding the functional significance of brain rhythms for learning and memory operations. Her lab also investigates how different brain rhythms affect neuronal ensemble representations of spatial memories, and how aberrant rhythmic activity influences neuronal activity and cognitive function in brain disorders. She received her PhD from the University of California at Irvine and completed her postdoctoral training in the Moser Lab at the Norwegian Institute of Science and Technology. She is a recipient of the Peter and Patricia Gruber International Research Award in Neuroscience, an Alfred P Sloan Foundation Research Fellowship, the Klingenstein Foundation Award in the Neurosciences, an Office of Naval Research Young Investigator award, and an NSF CAREER award.

    Expertise
    Neuroscience
    Research focus
    Brain rhythms
    memory operations
    entorhinal-hippocampal network
    aberrant rhythmic activity in brain disorders
    place cells
    grid cells
    Competing interests statement
    Laura Colgin currently receives funding from the National Institutes of Health, the USAMRMC Congressionally Directed Medical Research Program, and the National Science Foundation. She is an Associate Editor for Progress in Neurobiology and a Review Editor for Frontiers in Synaptic Neuroscience. She serves on the Scientific Review Board for the Simons Foundation SFARI initiative and is a member of the Neurobiology of Learning and Memory (LAM) study section for the National Institutes of Health.
  13. Jonathan A Cooper

    Jonathan A Cooper

    Fred Hutchinson Cancer Research Center, United States

    Jon Cooper is a member of the Fred Hutchinson Cancer Research Center in Seattle, where he is also a Senior Vice-President and Director of the Division of Basic Sciences. He holds an Affiliate Professor appointment in the Biochemistry department at the University of Washington. After undergraduate studies at the University of Cambridge and post-graduate research at the University of Warwick, he performed postdoctoral research with Bernard Moss at the NIH and with Tony Hunter at the Salk Institute. With Tony, he found that oncogenic retroviruses (Rous sarcoma virus and others) and growth factors (EGF and PDGF) stimulate the tyrosine phosphorylation of overlapping subsets of cell proteins, which were candidates to regulate cell proliferation and metabolism. He joined Fred Hutch in 1985 to continue the work he started at the Salk, investigating the mechanisms by which protein kinases regulate cell proliferation and transformation. His laboratory played important roles in establishing how Src is regulated, how activated growth factor receptors recruit signaling proteins, and Ras-Raf-MAPK signaling. In 1995, postdoc Brian Howell knocked out the gene for a Src substrate and observed a distinctive brain development phenotype. Efforts by several laboratories rapidly established a signaling pathway that regulates neuron migrations during brain development. Further studies on this pathway revealed the importance of ubiquitination and degradation for terminating signaling, and led in recent years to detailed investigation of the roles of Cullin-RING ligases in regulating signal transduction events in vivo and in cultured cells.

    Expertise
    Cell Biology
    Neuroscience
    Research focus
    signaling pathways
    cell migration
    phosphorylation
    cell transformation
    Competing interests statement
    Jon Cooper receives research grants from the NIH and he serves on the editorial board of Molecular and Cellular Biology.
  14. Floris de Lange

    Donders Institute for Brain, Cognition and Behaviour, Netherlands

    Floris de Lange is a Professor at the Radboud University in Nijmegen, Netherlands and Principal Investigator of the Predictive Brain Lab at the Donders Institute, where he studies how various forms of prior knowledge modify perception and decision-making, both in health and disease. He is an elected member of the Young Academy of the Royal Netherlands Academy of Sciences (KNAW) and the International Neuropsychological Society (INS).

    Expertise
    Neuroscience
    Research focus
    perception
    prediction
    attention
    decision-making
    neuroimaging
    Experimental organism
    human
    Competing interests statement
    Editorial duties include membership of the Wellcome Trust Cognitive Neuroscience and Mental Health Expert Review Group. Current funding includes ERC Starting Grant (European Research Committee, ERC), Vidi Innovational Research Incentives Scheme Award (Netherlands Science Foundation, NWO) and the James S McDonnell Scholar Award (McDonnell Foundation).
  15. Harry Dietz

    Harry Dietz

    HHMI, Johns Hopkins University School of Medicine, United States

    Dr Dietz is Victor A McKusick Professor of Pediatrics, Medicine, and Molecular Biology & Genetics in the Institute of Genetic Medicine at the Johns Hopkins University School of Medicine. He is also an Investigator at the Howard Hughes Medical Institute. His undergraduate training in biomedical engineering was performed at Duke University and his MD degree was received from the Health Sciences University of Syracuse. Clinical and research training in pediatrics, pediatric cardiology, and genetics occurred at Johns Hopkins University School of Medicine. Dr Dietz’s research is focused on elucidation of the etiology and pathogenesis of connective tissue disorders that involve the cardiovascular system. Dr Dietz has received multiple prestigious awards including the Curt Stern Award from the American Society of Human Genetics, the Taubman Prize for excellence in translational medical science, and the Harrington Prize from the American Society for Clinical Investigation and the Harrington Discovery Institute. He is an inductee of the American Society for Clinical Investigation, American Association for the Advancement of Science, Academy of American Physicians, The National Academy of Medicine, Association of American Physicians, and the National Academy of Sciences.

    Expertise
    Human Biology and Medicine
    Genetics and Genomics
    Research focus
    human genetics
    extracellular matrix
    connective tissue disorders
    genetics of cardiovascular disease
    Competing interests statement
    Hal Dietz receives funding from the Howard Hughes Medical Institute, National Institutes of Heath, Leducq Foundation, Marfan Foundation, and Scleroderma Research Foundation. He currently serves on the editorial board of Science Translation Medicine and the Journal of Clinical Investigation. He serves on the advisory board of GlaxoSmithKline, is founder and consultant for Blade Therapeutics, and also consults for Eli Lilly and Bristol-Myers Squibb. He is President Elect of the American Society of Human Genetics.
  16. Catherine Dulac

    Catherine Dulac

    Harvard University, United States

    Catherine Dulac is a Howard Hughes Medical Institute Investigator, Higgins Professor of Molecular and Cellular Biology, and Chair of the Department of Molecular and Cellular Biology in the Faculty of Arts & Sciences at Harvard University. Her work explores the molecular biology of pheromone detection and signaling in mammals, and the neural mechanisms underlying age-, species-, and sex-specific behaviors. She graduated from the Ecole Normale Supérieure, Paris; received her PhD from the University of Paris VI at the Institute of Molecular and Cellular Embryology (Nogent-sur-Marne); and was a postdoctoral fellow at Columbia University. She is a Fellow of the American Academy of Arts and Sciences; of the American Association for the Advancement of Science; and a member of the French Academy of Sciences, Institute of France. She is a recipient of the Liliane Bettencourt Prize, the Richard Lounsbery Award, the Perl/UNC Neuroscience Prize and the IPSEN Foundation Neuronal Plasticity prize.

    Expertise
    Neuroscience
    Research focus
    cellular and molecular neuroscience
    molecular and genetic basis of sex and species-specific social behavior
    Competing interests statement
    Catherine Dulac receives funding from the Howard Hughes Medical Institute and the National Institutes of Health. She is a member of the editorial boards of Current Opinion in Neurobiology and The Journal of Comparative Neurology. She is a member of selection committees for the following awards and prizes: McKnight Foundation Technical Innovation Award, Radcliffe Institute for Advanced Study Fellowship Program, The Esther A. and Joseph Klingenstein Fund, the New York Stem Cell Foundation Innovator Awards in Neuroscience, the Smith Family Awards Program for Excellence in Biomedical Research and the Searle Scholars. She also serves on the Scientific Advisory Boards for the following organizations: Senomyx, Allen Institute, Friedrich Miescher Institute for Biomedical Research, and the Max Planck Institute for Medical Research. She is a member of the Visiting Committee for MIT’s Department of Brain and Cognitive Sciences, and she serves as a reviewer for the National Institutes of Health Somatosensory and Chemosensory Study Section.
  17. Neil Ferguson

    Imperial College London, United Kingdom

    Neil Ferguson is Head of the Department of Infectious Disease Epidemiology at Imperial College London, where he leads the MRC Centre for Outbreak Analysis and Modelling. His research aims to improve the understanding of epidemiological factors and population processes that shape infectious disease spread in human and animal populations. A practical focus of his work is the analysis and optimisation of intervention strategies that are aimed at reducing transmission or disease burden.

    Expertise
    Epidemiology and Global Health
    Microbiology and Infectious Disease
    Research focus
    epidemiology and infectious disease
    emerging infections
    mosquito-borne infections
    statistical and mathematical tools
  18. Eduardo Franco

    McGill University, Canada

    Eduardo Franco is Professor and Chairman, Department of Oncology, and Director, Division of Cancer Epidemiology, McGill University, Montreal. He holds BSc (1975) and Licentiate (1976) degrees in biology from Universidade de Campinas, Brazil, and master's (MPH) and doctoral (DrPH) degrees in public health microbiology from the University of North Carolina at Chapel Hill (1981-84). He was a Guest Researcher at the US Centers for Disease Control in Atlanta (1980-81 and 1983-84), and a post-doctoral fellow in cancer epidemiology during 1984 at the International Agency for Research on Cancer in Lyon, France, at the US National Cancer Institute (NCI) in Bethesda, and at Louisiana State University, in New Orleans. Since 1985, he has conducted epidemiologic research on the causes of cancer and on the means to prevent it or to improve patient survival. He is mostly known for his contributions to our understanding of human papillomavirus infection as the cause of cervical cancer and using this knowledge to prevent this cancer via vaccination and improved screening strategies. He received the Canadian Cancer Research Alliance’s Distinguished Service to Cancer Research Award, Lifetime Achievement Awards from the American Society for Colposcopy and Cervical Pathology and from the International Papillomavirus Society, the Women in US Government’s Leadership Award, the Canadian Cancer Society’s Warwick Prize, the Geoffrey Howe Outstanding Contribution Award from the Canadian Society for Epidemiology and Biostatistics, the University of British Columbia’s Chew Wei Memorial Prize in Cancer Research, and the McLaughlin-Gallie Award from the Royal College of Physicians of Canada. He has mentored 115 graduate students and post-doctoral fellows, and 30 undergraduate trainees. He is Officer of the Order of Canada and Fellow of the Royal Society of Canada and of the Canadian Academy of Health Sciences. Heholds an honorary doctorate from Universidade Fernando Pessoa, Porto, Portugal.

    Expertise
    Cancer Biology
    Epidemiology and Global Health
    Human Biology and Medicine
    Research focus
    molecular epidemiology and prevention of cervical cancer and human papillomavirus-associated diseases
    cancers of the upper aero-digestive tract
    prostate, endometrium, and childhood tumours
    efficacy of cancer screening strategies
    the impact of measurement error in epidemiology
    societal and clinical influences on cancer patient survival
    Competing interests statement
    Entire research program funded by the Medical Research Council of Canada (until 1999), Canadian Institutes of Health Research (CIHR) (1999-present), National Institutes of Health, Canadian Cancer Society, and Cancer Research Society. He has received salary awards from the Fonds de Recherche Quebec Santé and CIHR. He holds a James McGill Professorship and the Minda de Gunzburg Endowed Chair at McGill University. He serves as Editor-in-Chief for Preventive Medicine and Preventive Medicine Reports and serves on the editorial boards of Cancer Epidemiology, Biomarkers & Prevention, International Journal of Cancer, Papillomavirus Research, and Salud Publica de Mexico. He has served as occasional consultant to companies involved with HPV vaccination (Merck and GSK) and HPV diagnostics (Roche, Abbott, Qiagen, and BD).
  19. Michael J Frank

    Brown University, United States

    Michael J Frank is Professor of Cognitive, Linguistic & Psychological Sciences affiliated with the Brown Institute for Brain Science at Brown University, where he directs the Brown Initiative for Computation in Brain and Mind. He received his PhD in Neuroscience and Psychology in 2004 at the University of Colorado, following undergraduate and master's degrees in electrical engineering and biomedicine. Dr. Frank’s work focuses primarily on theoretical models of frontostriatal circuits and their modulation by dopamine, especially in terms of their cognitive functions and implications for neurological and psychiatric disorders. The models are tested and refined with multimodal experiments across species. He is a Kavli Science Fellow, and recipient of the Cognitive Neuroscience Society Young Investigator Award (2011), the Janet T Spence Award for early career transformative contributions (Association for Psychological Science, 2010) and the DG Marquis award for best paper published in Behavioral Neuroscience (2006).

    Expertise
    Neuroscience
    Research focus
    computational neuroscience
    prefrontal cortex
    basal ganglia
    cognitive control
    reinforcement learning
    Competing interests statement
    Michael Frank serves of the editorial boards of Journal of Neuroscience and Behavioral Neuroscience, and he receives consulting fees for work with F Hoffman LaRoche Pharmaceuticals.
  20. Wendy S Garrett

    Wendy S Garrett

    Harvard T.H. Chan School of Public Health, United States

    Wendy Garrett is a Professor of Immunology and Infectious Diseases at the Harvard T. H. Chan School of Public Health, co-Director of the Harvard Chan Center for the Microbiome in Public Health, and an Associate Member of the Broad Institute. Her work explores host-microbiota interactions underlying mucosal immune homeostasis, gastrointestinal inflammatory disorders, and cancer. She graduated from the Yale College; received her MD PhD from Yale University and completed post-graduate training at Harvard.

    Expertise
    Immunology and Inflammation
    Microbiology and Infectious Disease
    Human Biology and Medicine
    Research focus
    host-microbiota interactions
    microbiome
    mucosal immunology
    Competing interests statement
    Wendy Garrett serves on advisory boards of Evelo Biosciences, Kintai Therapeutics, and Leap Therapeutics. She is a member of the Cell Reports and Journal of Clinical Microbiology editorial boards.
  21. Joshua I Gold

    University of Pennsylvania, United States

    Joshua I Gold is Professor of Neuroscience, Chair of the Neuroscience Graduate Group, and Co-Director of the Computational Neuroscience Initiative at the University of Pennsylvania, where he has been since 2002. He studied models of synaptic plasticity with Drs Mark Bear and Leon Cooper as an undergraduate at Brown University, plasticity in the sound-localization pathway of the barn owl with Dr Eric Knudsen as a graduate student at Stanford University, and computational and neural mechanisms of deicsion-making with Dr Michael Shadlen as a post-doc at the University of Washington. Gold currently studies the neural basis of learning and decision-making in the primate brain, with a focus on interactions between physiological arousal and cognitive processing. His work uses several complementary approaches, including theory and modeling; measures of behavior and pupil diameter in humans; and measures of behavior, pupil diameter, and brain activity in non-human primates. Much of his current work involves understanding how the brain adaptively processes information in dynamic environments. He won early career awards from the Burroughs-Wellcome Fund, the McKnight Foundation, and the Sloan Foundation.

    Expertise
    Neuroscience
    Research focus
    computational neuroscience
    systems neuroscience
    decision-making
    perception
    arousal
    learning
    electrophysiology
    Competing interests statement
    Joshua Gold is employed by the University of Pennsylvania. He receives funding from the National Institutes of Health, the National Science Foundation, and the Office of Naval Research. He has also received funding from the Burroughs Wellcome Fund, the McKnight Foundation for Neuroscience, and the Sloan Foundation. He is on the editorial board of the Journal of Neurophysiology.
  22. Christian S Hardtke

    Christian S Hardtke

    University of Lausanne, Switzerland

    Christian Hardtke obtained a PhD in Developmental Biology from the Ludwig-Maximilians University of Munich in 1997 for his work on plant embryogenesis. He then moved to Yale University as an HFSP postdoctoral fellow to study photomorphogenesis, before joining McGill University as Assistant Professor in 2001. He was appointed Associate Professor at the University of Lausanne in 2004, where he became Full Professor and director of the Department of Plant Molecular Biology in 2010. His research revolves around the molecular genetic control of plant development, with a focus on quantitative aspects of plant growth and morphology. He is particularly interested in mechanisms of vascular tissue differentiation and their relation to root system architecture, as well as the intersection of these mechanisms with natural genetic variation.

    Expertise
    Plant Biology
    Developmental Biology
    Research focus
    plant development
    developmental cell biology
    natural variation
    Experimental organism
    A. thaliana
    Brachypodium
    Competing interests statement
    Christian Hardtke has received funding from the Human Frontier Science Program, the Natural Sciences and Engineering Research Council of Canada, various EU research programs and the Swiss National Science Foundation. He is currently an editor of Plant and Cell Physiology and also serves on the editorial board of EMBO Reports.
  23. Richard Ivry

    University of California, Berkeley, United States

    Rich Ivry is a Professor of Psychology and Neuroscience at the University of California, Berkeley. Ivry studies various aspects of human performance using behavioral studies in healthy and neurologically impaired populations, brain stimulation, neuroimaging, and computational modeling. His work has advanced our understanding of how people select and implement movements, and acquire new motor skills, with a special interest in how subcortical systems interact with the cortex in sensorimotor control and learning. For over a decade, Ivry served as an associate editor for the Journal of Cognitive Neuroscience and is co-author of the textbook, The Cognitive Neurosciences: The Biology of the Mind.

    Expertise
    Neuroscience
    Research focus
    cognitive neuroscience and psychology
    non-invasive brain stimulation
    human performance
    sensorimotor control and learning
    behavior
    cognition
    brain
    attention
    coordination
    executive control
    motor control
    motor learning
    Competing interests statement
    Rich Ivry receives funding from the National Institutes of Health. He serves on the editorial boards of the Journal of Cognitive Neuroscience and the Cerebellum.
  24. Andrew J King

    Andrew J King

    University of Oxford, United Kingdom

    Andrew King is Professor of Neurophysiology and a Wellcome Trust Principal Research Fellow at the University of Oxford, where he heads the Auditory Neuroscience Group in the Department of Physiology, Anatomy and Genetics. His research uses an interdisciplinary approach to investigate the neural basis for auditory perception and multisensory integration. His group is currently investigating the representation and coding of sound features by populations of neurons, how neural responses adjust to changes in the statistical distribution of sounds associated with different acoustic environments, and the capacity of the brain to compensate for the changes in inputs that result from hearing loss. He was awarded the Wellcome Prize in Physiology in 1990 and was made a Fellow of the UK Academy of Medical Sciences in 2011.

    Expertise
    Neuroscience
    Research focus
    Ferret
    auditory system
    auditory perception
    multisensory integration
    Competing interests statement
    Andrew King receives funding for his research from the Wellcome Trust, the University of Oxford, and from Action on Hearing Loss. He serves on the editorial boards of The Journal of Physiology and Frontiers in Systems Neuroscience. He is a member of the Sir Henry Dale Fellowship Interview Committee, Action on Hearing Loss PhD Review Panel, Auditory Verbal UK Advisory Board, and the Agir Pour L’Audition Scientific Prize Committee.
  25. Karla Kirkegaard

    Stanford University School of Medicine, United States

    Karla Kirkegaard is the Violetta L Horton Research Professor of Genetics and former Chair of the Department of Microbiology and Immunology in the Stanford University School of Medicine. She received her PhD in Biochemistry and Molecular Biology with James C Wang at Harvard University, and performed her postdoctoral work in the laboratory of David Baltimore at the Whitehead Institute. As an Assistant and Associate Professor at the University of Colorado in Boulder, she received numerous awards, including a fellowship from the David and Lucile Packard Foundation, an American Cancer Society Young Investigator Award, a Searle Scholar Award, and sponsorship by the Howard Hughes Medical Institute. Karla Kirkegaard combined her interests in biochemistry, cell biology, and genetics in the study of RNA virology, using poliovirus and other positive-strand RNA viruses to understand the cell biology of viral infections and the genetics of viral variability. Since her move to Stanford University School of Medicine in 1996, her interests have focused increasingly on the impact of basic science discoveries on the transmission of viruses in infected hosts. Kirkegaard’s honors include an Ellison Foundation Senior Scholar Award in Global Infectious Disease and, in 2006, the NIH Director’s Pioneer Award, for her approach to guide the selection of antiviral targets with the goal of suppressing the drug-resistant RNA genomes that will inevitably be formed due to the high error rates of RNA replication. She has been recently elected as a Member of the National Academies of Arts and Sciences and a Fellow of the American Association for the Advancement of Science. Her work continues to focus on the mechanisms of diversity and propagation of viruses and suppression of this diversity and spread.

    (Reproduced from http://web.stanford.edu/group/kirkegaard/karla.html)

    Expertise
    Microbiology and Infectious Disease
    Immunology and Inflammation
    Research focus
    drug resistance
    viral evolution
    dominant genes
    Experimental organism
    human
    mouse
    viruses
  26. John Kuriyan

    John Kuriyan

    University of California, Berkeley, United States

    John Kuriyan is Professor of Molecular and Cell Biology and also of Chemistry at the University of California, Berkeley. Before this, he was on the faculty at The Rockefeller University, New York, where he began his career in 1987, leaving for Berkeley in 2001. Since 1990, he has been an Investigator of the Howard Hughes Medical Institute. Kuriyan completed undergraduate studies in chemistry at Juniata College, Huntingdon, PA. His doctoral research, on the dynamics of proteins, was carried out at MIT, under the guidance of Greg Petsko and Martin Karplus (Harvard University). Kuriyan’s research is aimed at understanding the structure and mechanism of the enzymes and molecular switches that carry out cellular signal transduction and DNA replication. His laboratory uses x-ray crystallography to determine the three-dimensional structures of proteins involved in signaling and replication, as well as biochemical, biophysical, and computational analyses to elucidate mechanisms. Kuriyan was elected to the US National Academy of Sciences in 2001.

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    protein science and biochemistry
    signaling
    crystallography
    electron microscopy
    modeling
    molecular dynamics
    Competing interests statement
    John Kuriyan has received funding from the Howard Hughes Medical Institute, the US National Institutes of Health, and the Leukemia and Lymphoma Society. He serves on the editorial board of the Proceedings of the National Academy of Sciences, and on the Scientific Advisory Boards of Carmot Therapeutics (San Francisco) and Jubilant Biosys (Bangalore). He is a founder of Nurix (San Francisco).
  27. Vivek Malhotra

    The Barcelona Institute of Science and Technology, Spain

    Vivek Malhotra was a professor in the biology division at UC San Diego from 2007 and is now the ICREA Professor and Chair of the Cell and Developmental Biology at Center for Genomic Regulation (CRG) in Barcelona. His research focuses on a central station of the secretory pathway, the Golgi complex. Specifically, his work has resulted in the identification of the machinery required for the sorting and packaging of secretory cargoes. His recent work has uncovered a novel secretory routing that bypasses the conventional pathway of protein secretion. He has identified new genes required for the export of bulky collagens and the regulated secretion of mucins. He received his BSc from Stirling University and was a Pirie–Reid scholar at Oxford; a Damon Runyon Walter Winchell and an American Cancer Society postdoctoral fellow at Stanford; and Basil O’Conner scholar, established Investigator of the American Heart Association, and Senior Investigator of Sandler’s Foundation for Asthma at UC San Diego. He received the MERCK award from the American Society of Biochemistry and Molecular Biology, is a fellow of the American association of the arts and science, and is an elected EMBO member.

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Research focus
    Golgi apparatus: biogenesis, structure, and function
    Collagen and Mucin secretion
    Competing interests statement
    Vivek Malhotra receives funding from ERC/European Research Council, Ministerio de Economía y Competitividad, AGAUR and the Plan Nacional (Spain) He is a Scientific Advisory Board member of TIGEM (Naples, Italy), CNR (Naples, Italy), CBMSO (Madrid, Spain) and Department of Biotechnology (India). He has served on the editorial board of Cell and was an associate editor of Molecular Biology of the Cell. He is currently on the editorial boards of Journal of Cell Biology and Current Opinion in Cell Biology.
  28. James Manley

    Columbia University, United States

    James Manley received a BS from Columbia University, a PhD from Stony Brook/Cold Spring Harbor Labs, and did postdoctoral work at MIT. He has been in the Department of Biological Sciences at Columbia University since 1980, was Chair from 1995–2001, and Julian Clarence Levi Professor of Life Sciences since 1995. His research interests center on understanding the mechanisms and regulation of gene expression in eukaryotes, especially with regard to mRNA splicing and 3’ end formation; how these processes are linked to transcription, cell signaling pathways, and maintenance of genomic stability; and how they contribute to cell differentiation and disease. He has authored or coauthored nearly 300 research articles and reviews on these topics, and is an ISI Highly Cited Researcher. Dr. Manley is a Fellow of the American Academy of Microbiology, the American Academy of Arts and Sciences, and the American Association for the Advancement of Science, and a member of the National Academy of Sciences.

    Expertise
    Chromosomes and Gene Expression
    Research focus
    chromosomes and gene expression
    transcription
    RNA processing
    translation
    RNA localization and turnover
    Experimental organism
    human
    S. cerevisiae
    Competing interests statement
    Jim Manley receives research support from the National Institutes of Health and Columbia’s Motor Neuron Center. He is currently an Associate Editor of Gene Expression and Editor of Molecular and Cellular Biology. He is also on the editorial boards of Genes and Development, RNA, Molecular Cell, BMC Molecular Biology, BMC Biology, Recent Patents on DNA & Gene Sequences, and Transcription.
  29. Michael Marletta

    Michael Marletta

    University of California, Berkeley, United States

    Michael Marletta is the Aldo DeBenedictis Distinguished Professor of Chemistry and of Biochemistry and Molecular Biology at the University of California, Berkeley. Previous to his appointment at UC Berkeley, he was a former President and CEO of The Scripps Research Institute. He has also been on the faculty of the University of Michigan, where he was an HHMI Investigator, and MIT. Marletta obtained an A.B. in chemistry and biology from the State University of New York at Fredonia, a Ph.D. from UCSF under George Kenyon and, after a postdoctoral appointment at MIT under Chris Walsh, began his independent career. His work has spanned protein chemistry and enzymology. He has made many contributions to our understanding of nitric oxide signaling and more generally in molecular mechanisms of gas sensing in eukaryotes and prokaryotes. More recent studies have involved novel enzymes involved with cellulose degradation. Marletta is a member of the National Academy of Sciences, the Institute of Medicine, and the American Academy of Arts and Sciences.

    Expertise
    Biochemistry and Chemical Biology
    Research focus
    chemical biology
    nitric oxide signaling
    gas sensing
    structural basis of enzyme activity
    Experimental organism
    E. coli
    human
    Competing interests statement
    Michael Marletta has received funding from the NIH, HHMI, and Burroughs-Wellcome Fund. He was a member of the PNAS Editorial Board (until July 2012) and Biochemistry. He is a Scientific Advisory Board member of Lycera, Inc., Galleon Pharmaceuticals, Viamet Pharmaceuticals, and N30. He serves on the Scientific Review Board of HHMI. He is an External Review Board member of the Vanderbilt Institute of Chemical Biology, Georgia Tech School of Chemistry and Biochemistry, and Chair, Natural Science Advisory Council, SUNY Fredonia. He is a co-founder of Omniox, Inc.
  30. Mark McCarthy

    Mark McCarthy

    University of Oxford, United Kingdom

    Mark McCarthy is the Robert Turner Professor of Diabetes Medicine at the University of Oxford, based at the Oxford Centre for Diabetes, Endocrinology, and Metabolism and the Wellcome Trust Centre for Human Genetics. He is also a Consultant Physician at the Oxford University Hospitals Trust and is currently Visiting Professor at the University of Geneva. Following medical training in Cambridge and London, a spell as an MRC Travelling Fellow at the Whitehead Institute in Massachusetts, and 8 years at Imperial College, he moved to Oxford in 2002. He is a physician-scientist and human geneticist interested in the biological basis of complex disease. His research group is focused on the identification and characterisation of genetic variants influencing risk of type 2 diabetes and related traits, and on using those discoveries to drive biological inference and translational opportunities. He works closely with colleagues in Oxford and beyond to establish the mechanisms whereby T2D-risk variants influence islet function, and to explore the value of this information to drive clinical advances. He has played a major role in establishing and leading a number of the global initiatives in this field including the DIAGRAM, MAGIC, GIANT, EGG, GoT2D, ENGAGE, and T2D-GENES consortia. He has been a Senior Editor at eLife since 2015.

    Expertise
    Genetics and Genomics
    Research focus
    genetics
    metabolism
    genome wide association and resequencing studies
    systems biology
    human genetics and genomics
    multifactorial disease
    metabolic disease
    biomarkers
    Experimental organism
    human
    Competing interests statement
    Mark McCarthy has received funding from the UK Medical Research Council, Wellcome Trust, Diabetes UK, British Heart Foundation, the (UK) National Institute for Health Research, the (US) National Institutes of Health, the European Commission, the Foundation of the NIH, the Juvenile Diabetes Research Foundation, and from the Innovative Medicines Initiative. He is a member of the Scientific Advisory Boards (or equivalent advisory committees) for the Wellcome Trust Sanger Institute (Human Genetics), the H3A Bionet, and Genome Quebec. He is a member of the MRC Population and Systems Medicine Board and Cross Board Cohort Advisory Group. He has, via the IMI, received research funding, and/or has research collaborations with multiple pharma companies including Pfizer, Lilly, Sanofi-Aventis, NovoNordisk, and Boehringer Ingelheim.
  31. Edward Morrisey

    University of Pennsylvania, United States

    Edward E Morrisey, PhD is the Robinette Professor of Medicine and a Professor of Cell and Developmental Biology at the University of Pennsylvania. Dr Morrisey received his BS degree from the University of Illinois and his PhD from Northwestern University. He is the founding Director of the Penn-CHOP Lung Biology Institute (LBI), an organization dedicated to identifying new therapeutic approaches to alleviate pulmonary disease by supporting research that spans basic discovery through translational application. The Morrisey Lab has identified many of the key cell lineages and molecular pathways that are critical for development and regeneration of the mouse and human lungs. Findings from his lab have been leveraged to generate human lung epithelial cells from pluripotent stem cells. The overall goals of his lab are to better understand how the lung responds to injury, whether pathways important for lung development are reactivated or suppressed after injury, and use this knowledge to identify ways to promote proper repair and regeneration of the respiratory system.

    Expertise
    Developmental Biology
    Stem Cells and Regenerative Medicine
    Research focus
    lung development
    cardiac development
    vascular development
    regulation of gene transcription
    wnt signaling
    GATA
    forkhead
    Competing interests statement
    Dr Morrisey has been an editor for several scientific journals including the Journal of Clinical Investigation and eLife. He has been or currently is a principal investigator on several NIH and privately supported research consortia related to stem cell and regenerative biology, including the Progenitor Cell Biology Consortium, the Lung Repair and Regeneration Consortium, the NextGen Stem Cell Consortium, the Progenitor Cell Translational Consortium, and the Longfonds BREATH Consortium.
  32. Maureen Murphy

    The Wistar Institute, United States

    Maureen E. Murphy, Ph.D., is a Professor and Program Leader in the Molecular and Cellular Oncogenesis Program of The Wistar Institute. Dr. Murphy joined Wistar in 2011 and became a Program Leader in early 2012. She is also an adjunct professor at Drexel University College of Medicine and The Perelman School of Medicine at the University of Pennsylvania. Previously, Dr. Murphy was a professor at the Fox Chase Cancer Center. Since 1999, she has received continuous support from the National Cancer Institute (NCI) for her research on the p53 tumor suppressor protein and the HSP70 molecular chaperone.

    A noted expert in the role of the p53 gene in cancer, Dr. Murphy’s laboratory focuses on how p53 functions to suppress tumor development. Through her lab’s work, Dr. Murphy is investigating the genetics of cancer health disparities. In efforts to improve precision medicine, her group is performing drug screens on tumor cells containing this variant, with the goal of finding drugs that will kill these cells preferentially. For her work on p53, Dr. Murphy is the recipient of the 2016 Gateway for Cancer Research Leadership in Cancer Advocacy Award. Murphy’s group also studies the stress-induced protein HSP70. With the knowledge that HSP70 is overexpressed in late stage cancers, Dr. Murphy’s group has pioneered the use of inhibitors of HSP70 for cancer therapy, particularly metastatic melanoma. For this effort, in 2014 her group won a Discovery Fast Track award from GlaxoSmithKline for the development of HSP70 inhibitors for cancer therapy.

    In addition to her research, Dr. Murphy also plays pivotal administrative roles as Wistar’s Associate Vice President for Faculty Affairs, the Principal Investigator of its Training Grant in Basic Cancer Research, the head of the Junior Faulty Mentoring program, and the Director of its Postdoctoral Training Program. A member of the NCI’s Cancer and Molecular Pathology (CAMP) federal grant review committee, Dr. Murphy has also reviewed grants for the New Jersey Commission for Cancer Research, the Department of Defense, and Alex’s Lemonade Stand Foundation for Pediatric Cancer Research.

    Dr. Murphy earned a Bachelor of Science degree in biochemistry at Rutgers University, followed by a doctorate in molecular biology at the University of Pennsylvania School of Medicine. In 1994, she began postdoctoral research at Princeton University in the laboratory of Arnold J. Levine, Ph.D., a co-discoverer of p53 and a pioneer in the field of tumor suppressor genes and cancer biology.

    Expertise
    Cancer Biology
    Research focus
    p53
    ferroptosis
    mitochondria
    colon cancer
    HSP70
    polymorphism
    Competing interests statement
    Maureen Murphy is a member of the American Association for Cancer Research (AACR). In addition to eLife, she holds editorial positions at Cancer Biology and Therapy (Senior Editor), Cancer Research (Senior Editor), Molecular Cancer Research and Carcinogenesis Integrative Research. She is a member of the NIH NCI Cancer and Molecular Pathology federal grant review committee, and receives federal funding from the National Institutes of Health (NIH).
  33. Päivi Ojala

    University of Helsinki, Finland
    Imperial College London, United Kingdom

    Päivi Ojala is the Professor of Cancer Cell Biology at University of Helsinki and Chair of Viral Tumorigenesis at Imperial College London. She has made significant contributions to the Kaposi’s Sarcoma herpesvirus (KSHV) field and has more recently focused also on the role of lymphatic endothelial microenvironment on cancer cell metastasis. She has expertise in organotypic 3D co-culture models, cell-based high-content screens, protein kinase signalling and viral technologies. Her work has led to demonstration of restoration of p53 function by small molecule inhibitors as a therapeutic modality for KSHV-induced lymphomas, identification of host Pim kinases, nucleophosmin, and the p53-p21 axis as novel regulators of viral replication, and shown that KSHV infection reprograms lymphatic endothelial cells (LECs) to a new, more invasive cell type. They have also demonstrated that LEC interaction with melanoma cells leads to increased distant organ metastasis in vivo, which is dependent on MMP14, Notch3 and b1-integrin- Dr. Ojala holds a doctoral degree in Molecular Genetics from the University of Helsinki, and has received postdoctoral training at the Yale School of Medicine, CT, USA.

    Expertise
    Cancer Biology
    Microbiology and Infectious Disease
    Research focus
    human tumor viruses
    virus-host interactions
    tumor microenvironment
    metastasis
    Competing interests statement
    Päivi Ojala receives funding from the Academy of Finland, Sigrid Juselius Foundation, Cancer Foundation Finland and University of Helsinki.
  34. Suzanne R Pfeffer

    Stanford University School of Medicine, United States

    Suzanne Pfeffer is the Emma Pfeiffer Merner Professor of Medical Sciences and Professor of Biochemistry at Stanford University School of Medicine. She is an expert in the field of membrane trafficking in the secretory and endocytic pathways, and her research currently focuses on the molecular basis of LRRK2-mediated, familial Parkinson's Disease and Niemann Pick Type C disease, with emphasis on Rab GTPase regulation and cholesterol export from lysosomes. She is a past President of the American Society for Cell Biology and the American Society of Biochemistry and Molecular Biology and a Fellow of the American Society for Cell Biology, the American Association for the Advancement of Science and the American Academy of Arts and Sciences.

    Expertise
    Cell Biology
    Research focus
    membrane traffic
    endosomes
    lysosomes
    golgi complex
    secretory pathway
    cholesterol transport
    Competing interests statement
    Suzanne Pfeffer's research is currently funded by the National Institutes of Health, the Michael J. Fox Foundation and the Ara Parseghian Medical Research Foundation. She serves on the Scientific Advisory Board of the Ara Parseghian Medical Research Foundation, the Swiss National Science Foundation funded NCCR program in Chemical Biology at the EPFL and University of Geneva, and she is a chartered member of the NIH NCSD review panel. Suzanne Pfeffer also serves as Co-Section Head for Membranes and Sorting, Faculty of 1000.
  35. Satyajit Rath

    Indian Institute of Science Education and Research (IISER), Pune, India

    Satyajit Rath was trained as a physician and a pathologist in Pune and Mumbai, India. He has worked on various issues related to the mechanisms involved in the development and functioning of the immune system since the nineteen-eighties, initially in post-doctoral stints across the world and then as a faculty member at the National Institute of Immunology (NII) in New Delhi over 1991-2017. Over 2017-2018, he held the Agharkar Chair at the Agharkar Research Institute, Pune, India. Currently, he is an adjunct faculty member at the Indian Institute of Science Education and Research (IISER) in Pune, at the Translational Health Science and Technology Institute, Faridabad, India, and at the Christian Medical College,Vellore, India. Satyajit also works on science-and-society policies as well as science education and outreach with both government agencies and civil society groups.

    Expertise
    Immunology and Inflammation
    Research focus
    immune physiology
    lymphocyte development
    lymphocyte responses
    macrophage activation
    immunity in disease
    Competing interests statement
    Research support for Satyajit's group over the years has come mainly from agencies of the government of India. He serves as a member of the scientific advisory committees/councils as well as management boards of a number of life science institutions in India. He currently serves as an Associate Editor for Frontiers in Immunology. He is a non-executive director of Ahammune Biosciences Private Limited, Pune, India, and a member of the scientific advisory boards of Curadev Pharma Private Limited, NOIDA, India, and Mynvax Private Limited, Bangalore, India.
  36. Peter Rodgers

    Features Editor, eLife, United Kingdom

    Peter joined eLife as Features editor in June 2012 and has worked in scientific publishing for more than twenty years. As Features Editor he oversees the non-research content of eLife and also the Digests that are included in all Research articles and Short reports. Previously he has been the Chief Editor of Nature Nanotechnology (2006-2012), where he had overall responsibility for all research and non-research content, and the Editor of Physics World magazine (1996-2005). Peter has a degree in physics from Imperial College London (1984) and a PhD from the Queen's University of Belfast (1988), and worked at the Rutherford Appleton Laboratory before joining Physics World as an Assistant Editor in 1990.

  37. David Ron

    Cambridge University, United Kingdom

    David Ron is a Professor at Cambridge University. He directs a lab at the Cambridge Institute for Medical Research (CIMR) studying protein-folding homeostasis in the endoplasmic reticulum (ER). The lab uses biochemical, biophysical and cell-based tools to research both the molecular mechanisms that recognize the burden of unfolded proteins and thus initiate signalling in the ER unfolded protein response (UPR) and the downstream effector pathways by which cells adapt to unfolded protein stress in their ER. These effector mechanisms engage post-translational regulation of ER chaperone function, regulated translation of mRNA and transcriptional control of gene expression and thus interface with other cellular stress pathways.

    To eLife, David Ron brings scientific expertise in the study of the unfolded protein response, chaperone function and stress-induced regulation of mRNA translation and editorial experience from having served as an eLife Reviewing Editor since 2012.

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Research focus
    chaperones
    unfolded protein response
    oxidative protein folding
    protein synthesis
    Experimental organism
    C. elegans
    E. coli
    human
    mouse
    S. cerevisiae
    Competing interests statement
    David Ron holds a Wellcome Trust Principal Research Fellowship and is on the editorial advisory boards of J. Cell Science, PLOS Biology and EMBO J.
  38. Clifford Rosen

    Maine Medical Center Research Institute, United States

    Dr Clifford Rosen is a Professor of Medicine at Tufts University School of Medicine and Principal Investigator for the Rosen Musculoskeletal Laboratory at the Maine Medical Center Research Institute (MMCRI). He is a board-certified endocrinologist with more than twenty-five years of continuous NIH funding, first at The Jackson Laboratory and subsequently at MMCRI. In the last ten years the Rosen laboratory has been studying mesenchymal stem cell fate with particular reference to the switch between pre-adipocytes and pre-osteoblasts, and with a focus on the bioenergetic programs of those progenitors. There are currently four NIH funded projects in his laboratory, focused on a central theme of lineage allocation, its biochemical determinants and its alterations in osteoporosis. An R24 program project on the biology of marrow adiposity is now finishing in its seventh year at NIDDK, and Dr. Rosen is the contact PI for that four-center interdisciplinary program. There are three other NIH funded research projects for which Dr Rosen serves as the PI: an R01 from NIDDK in collaboration with Roland Baron at Harvard Medical Dental School that examines the role of the PTH1R in cell fate, an RO1 from NIAMS studying mechanical strength in outbred strains of mice and an R21 (NIAMS) to delineate the impact of anabolic therapy on marrow adipogenesis. A U19 Program Project from NIA has recently been awarded to Dr Rosen and Zaidi on the effects of FSH as an aging hormone. Dr Rosen is also the Director of the Physiology Core of the MMCRI Stem Cell COBRE and the newly-funded COBRE in Mesenchymal and Neural Regulation of Metabolic Networks (NIGMS). The Rosen laboratory has also been interested in mitochondrial function in osteoblasts with an R21 on control of osteogenic bioenergetics that was recently completed. He also serves as the Principal Investigator for a NIGMS sponsored U54: The Northern New England Clinical and Translational Research Network

    Expertise
    Human Biology and Medicine
    Research focus
    skeletal biology
    bone disease
    Experimental organism
    mouse
    Competing interests statement
    Dr Rosen is the past president of ASBMR and is a council member for the Endocrine Society. He is an Associate Editor at New England Journal of Medicine. Dr Rosen is a member of the NIH Advisory (NACA) Council.
  39. Christian Rutz

    University of St Andrews, United Kingdom

    Christian Rutz is Professor of Biology at the University of St Andrews, Scotland, where he heads a research group studying animal tool behaviour. He combines observational, experimental and theoretical approaches, to investigate why tool use is so rare across the animal kingdom, and how rudimentary technologies advance and diversify. Since 2005, he has been leading a long-term field project on New Caledonian crows – tropical birds that have the remarkable ability to fashion complex foraging tools from plant materials. Rutz led the team that discovered in 2013 that the critically-endangered Hawaiian crow is also a highly skilled tool user, opening up exciting opportunities for comparative research. He has pioneered the use of miniature, animal-borne video-cameras and proximity loggers for studying wild birds, and currently serves as Founding President of the International Bio-Logging Society. With long-standing interests in conservation biology and science policy making, he is currently contributing to efforts to extend the scope of UNEP’s Convention on the Conservation of Migratory Species of Wild Animals (CMS). Rutz obtained his doctorate as a Rhodes Scholar from the University of Oxford, was subsequently awarded a £1.44-million David Phillips Research Fellowship to establish an independent research group (first at Oxford, and later at St Andrews), and held visiting appointments at the Universities of Oxford, Tokyo and New South Wales. His research has attracted a string of academic awards – including the 2014 Isambard–Kingdom–Brunel Award (British Science Association), the 2014 Hans Löhrl Prize (German Ornithologists’ Union), and the 2013 Marsh Award for Innovative Ornithology (British Trust for Ornithology) – and was showcased at the 2017 Royal Society Summer Science Exhibition in London, UK. Rutz was elected in 2013 to the Royal Society of Edinburgh’s Young Academy of Scotland (YAS), and has recently been named the 2019–2020 Grass Fellow at Harvard University’s Radcliffe Institute for Advanced Study, USA. Christian Rutz's broad areas of expertise are behavioural ecology, evolutionary ecology, urban ecology, comparative cognition, field ornithology and bio-logging science.

    Expertise
    Ecology
    Research focus
    tool behaviour
    social learning and cultural evolution
    animal behaviour and cognition
    foraging ecology
    predator-prey systems
    urban ecology
    conservation biology
    policy making
    animal tracking (bio-logging/bio-telemetry)
    Experimental organism
    crow
    raptors
    birds
    human
    Competing interests statement
    Christian Rutz is employed by the University of St Andrews, UK, holds a Senior Visiting Fellowship at the University of New South Wales, Australia, and is the 2019–2020 Grass Fellow at the Radcliffe Institute for Advanced Study, Harvard University, USA. Most of his research was, and still is, funded by competitive grants from the UK’s Biotechnology and Biological Sciences Research Council (BBSRC). He was an elected member of the Royal Society of Edinburgh’s Young Academy of Scotland (YAS), and is presently serving as Founding President of the International Bio-Logging Society, Scientific Advisor for UNEP’s Convention on the Conservation of Migratory Species of Wild Animals (CMS), and Editor of Ethology.
  40. Jeffrey Settleman

    Pfizer, United States

    Jeff Settleman is Senior Vice President and Group Head of Oncology Research and Development at Pfizer. Before joining Pfizer, Dr. Settleman was Head of Oncology Research at Calico Life Sciences, an aging-focused biotechnology company in South San Francisco. His research is focused on cancer cell biology and therapeutics. He is particularly interested in mechanisms of drug resistance and the phenotypic heterogeneity within cell populations that drives tumor evolution. He received a Ph.D. degree in Genetics from Yale University in 1989, conducting thesis research under the mentorship of Dr. Dan Dimaio, and from 1989-1992 was a postdoctoral fellow at the Whitehead Institute for Biomedical Research at M.I.T. in Dr. Robert Weinberg’s laboratory. He joined the Harvard School of Medicine faculty in 1992, and was named the Laurel Schwartz Professor of Oncology at Harvard Medical School in 2008. He was also the Director of the Center for Molecular Therapeutics, the Scientific Director of the Massachusetts General Hospital Cancer Center, and the Leader of the Cancer Cell Biology program within the Dana Farber/Harvard Cancer Center. In 2010, Dr. Settleman transitioned from academia to industry, joining Genentech as the Senior Director of Discovery Oncology, where he oversaw efforts to identify and validate targets for oncology drug discovery and to discover predictive biomarkers for new cancer therapies.

    Expertise
    Cancer Biology
    Research focus
    cancer cell biology
    signal transduction
    tumor heterogeneity
    signaling
    epigenetics
  41. Barbara G Shinn-Cunningham

    Carnegie Mellon University, United States

    Barbara Shinn-Cunningham is an electrical engineer turned neuroscientist who uses behavioral, neuroimaging, and computational methods to understand auditory processing and perception. Her interests span from sensory coding in the cochlea to influences of brain networks on auditory processing in cortex (and everything in between). She is the Director of the Carnegie Mellon Neuroscience Institute, a position she took up after over two decades on the faculty of Boston University. In her copious spare time, she competes in saber fencing and plays the oboe/English horn. She received the 2019 Helmholtz-Rayleigh Interdisciplinary Silver Medal and the 2013 Mentorship Award, both from the Acoustical Society of America (ASA). She is a Fellow of the ASA and of the American Institute for Medical and Biological Engineers, a lifetime National Associate of the National Research Council, and a recipient of fellowships from the Alfred P Sloan Foundation, the Whitaker Foundation, and the Vannevar Bush Fellows program.

    Expertise
    Neuroscience
    Research focus
    auditory perception
    auditory cognitive neuroscience
    attention
    sensory coding
    fMRI
    EEG
    MEG
    computational modeling
    Experimental organism
    human
    Competing interests statement
    Barbara Shinn-Cunningham receives funding from the National Institutes of Health, the National Science Foundation, the Office of Naval Research, and the Department of Defense. She is on the editorial board of Auditory Perception and Cognition.
  42. Dominique Soldati-Favre

    University of Geneva, Switzerland

    Dr Dominique Soldati-Favre studied biochemistry and earned her PhD degree in molecular biology from the University of Zürich (Switzerland) in 1990. She then conducted postdoctoral research in the Department of Microbiology and Immunology of the Stanford University School of Medicine. In 1995 she was appointed assistant professor at the Center for Molecular Biology at the University of Heidelberg (Germany). In 2001 she moved to Imperial College London (United Kingdom) and became Reader. Since 2004, she is professor at the Faculty of Medicine of the University of Geneva.

    Her laboratory is studying obligate intracellular parasitism using Toxoplasma gondii and is also increasingly engaged in malaria research. The main line of research focuses on the cell biology underlying how these pernicious pathogens glide into mammalian cells. Her group is also aiming at defining the metabolic needs and capabilities of the parasites as well as how they subvert host cellular functions in particular to access nutrients.

    Expertise
    Microbiology and Infectious Disease
    Research focus
    parasitology
    cell motility
    signaling
    proteases
    protein trafficking
    organelle biogenesis
    metabolism
    Experimental organism
    T. gondii
    P. falciparum
    Competing interests statement
    Dominique Soldati-Favre currently receives funding from the European Research Council and from the Swiss National Science Foundation. She is editor for Parasitology at Molecular Microbiology and she is on the editorial boards of PLOS Pathogens, Traffic and mBio.
  43. Didier Stainier

    Max Planck Institute for Heart and Lung Research, Germany

    Didier Stainier is the director of the Department of Developmental Genetics at the Max Planck Institute for Heart and Lung Research, Bad Nauheim (Frankfurt), Germany. He studied Biology in Wales, Belgium and the USA (Brandeis University) where he got a BA in 1984. He then received his PhD in Biochemistry and Biophysics from Harvard University (1990) where he investigated the cellular basis of axon guidance and target recognition in the developing mouse brain with Wally Gilbert. After a Helen Hay Whitney postdoctoral fellowship with Mark Fishman at the Massachusetts General Hospital (Boston), where he initiated the studies on zebrafish cardiac development, he set up his lab at the University of California, San Francisco in 1995, where he expanded his research to investigate questions of cell differentiation, tissue morphogenesis, organ homeostasis and function, as well as organ regeneration, in the zebrafish cardiovascular system and endodermal organs. In 2012, he moved to the Max Planck Institute where he continues to utilize both forward and reverse genetic approaches to investigate cellular and molecular mechanisms of developmental processes during vertebrate organ formation, in both zebrafish and mouse. He is also an Honorary Professor at Goethe University in Frankfurt. In addition to research and mentorship awards at UCSF, he was a Packard Fellow, Basil O’Connor scholar, established Investigator of the American Heart Association, received the American Association of Anatomists Harland Mossman Award in Developmental Biology, and was elected as a Fellow of the American Association for the Advancement of Science, Academia Europaea and European Molecular Biology Organization, as well as an Officier de l’ordre de Léopold de Belgique.

    Expertise
    Developmental Biology
    Research focus
    developmental genetics
    organogenesis
    tissue morphogenesis
    organ homeostasis
    Experimental organism
    zebrafish
    mouse
    Competing interests statement
    Didier Stainier has received funding from the Max Planck Society, the European Research Council, the National Institutes of Health, the Packard Foundation, the Deutsche Forschungsgemeinschaft, the American Heart Association, the Juvenile Diabetes Research Foundation and the Leducq Foundation among others. In addition to being a Senior Editor for eLife, he currently serves as a Managing Editor for Mechanisms of Development, is on the editorial board of Development and FEBS letters, and is an International Strategic Advisor for the National Institute of Genetics in Mishima, Japan. He previously served as a Section Editor for BMC Developmental Biology and was the founding chair of the Dev1 study section of the National Institutes of Health.
  44. Gisela Storz

    National Institute of Child Health and Human Development, United States

    Gisela Storz has been an Investigator in the Eunice Kennedy Shriver Institute of Child Health and Human Development in Bethesda, Maryland since 1991. She obtained a BA in Biochemistry from the University of Colorado in 1984 and a PhD in Biochemistry from the University of California, Berkeley in 1988, where she studied the bacterial response to oxidative stress working with Bruce Ames. Her current work is focused on understanding gene regulation in response to environmental signals and elucidating the roles of small RNAs and small proteins of less than 50 amino acids in these regulatory networks. Dr. Storz was the recipient of the American Society for Microbiology Eli Lilly Award and is a member of the American Academy of Microbiology, American Academy of Arts and Sciences and US National Academy of Sciences.

    Expertise
    Microbiology and Infectious Disease
    Chromosomes and Gene Expression
    Research focus
    small noncoding RNAs
    oxidative stress
    gene regulation
    bacterial physiology
    regulatory RNAs
    Experimental organism
    E. coli
    Competing interests statement
    Gisela Storz is employed by the Intramural Program of the National Institutes of Health. She served on the Scientific Advisory Board of Max Planck Institute for Terrestrial Microbiology. In addition to being a Senior Editor for eLife, she is an Editor at RNA and on the Editorial Boards of mBio, Annual Reviews of Genetics and Microbiology Spectrum.
  45. Kevin Struhl

    Harvard Medical School, United States

    Kevin Struhl received a BS and MS from MIT, a PhD from Stanford University Medical School, and did postdoctoral work at the MRC Laboratory of Molecular Biology in Cambridge, UK. He has been in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School since 1982, was acting Chair from 1997–98, and has been the David Wesley Gaiser Professor since 1991. His research combines genetic, molecular, genomic, and evolutionary approaches to address a wide variety of fundamental questions about transcriptional regulatory mechanisms and chromatin structure in yeast. In addition, he is interested in elucidating transcriptional regulatory circuits that mediate the process of cellular transformation and the formation of cancer stem cells. He has authored or co-authored nearly 300 research articles and reviews, and is an ISI Highly Cited Researcher. He received the Eli Lilly Award in Microbiology and is a Distinguished Researcher at the Institute of Molecular Biology and Biotechnology in Crete. Dr. Struhl is a Fellow of the American Academy of Microbiology, the American Association for the Advancement of Science, the American Academy of Arts and Sciences, the National Academy of Sciences, and the National Academy of Medicine.

    Expertise
    Chromosomes and Gene Expression
    Cell Biology
    Research focus
    chromatin biology
    cancer biology
    transcription mechanisms
    transcription
    gene regulatory circuits
    epigenetics
    mRNA decay
    biological function
    cellular transformation
    cancer stem cells
    molecular biology
    Competing interests statement
    Kevin Struhl receives funding from the National Institutes of Health. He is on the Scientific Advisory Board of Sangamo, Inc and the Klarman Cell Observatory at the Broad Institute. He is on the editorial boards of Current Protocols in Molecular Biology and Epigenetics and Chromatin.
  46. Kenton J Swartz

    National Institute of Neurological Disorders and Stroke, NIH, United States

    Kenton Swartz has been a Senior Investigator in the National Institute of Neurological Disorders and Stroke within the National Institutes of Health in Bethesda, Maryland since 2003. He obtained a BS in Chemistry and Biology from Eastern Mennonite College in 1986 and a PhD in Neurobiology from Harvard Medical School in 1993, where he worked with Bruce Bean studying the regulation of voltage-gated calcium channels by G-proteins and protein kinases. He obtained postdoctoral training with Roderick MacKinnon at Harvard Medical School, where he began isolating and studying toxins that interact with voltage-activated potassium channels. His laboratory uses biochemical, molecular biological, biophysical and structural techniques to understand how ion channel proteins sense critical biological stimuli, including membrane voltage, temperature, and both chemical and mechanical signals. He received an NIH Directors Award for Scientific Achievement in 2008, an NIH Office of the Director Honor Award on behalf of the Diversity Task Force in 2011 and the Kenneth S. Cole Award from the Biophysical Society in 2017. He has also served as the president of the Society of General Physiologists.

    Expertise
    Structural Biology and Molecular Biophysics
    Neuroscience
    Research focus
    ion channel proteins as molecular sensors
    voltage-activated ion channels
    Transient Receptor Potential (TRP) channels
    ATP-activated P2X receptor channels
    Mechanosensitive ion channels
    Competing interests statement
    Kenton Swartz is employed by the Intramural Research Program of the National Institute of Neurological Disorders and Stroke, National Institutes of Health. In addition to serving as a Senior Editor at eLife, he has served as a Reviewing Editor for eLife and as an Associate Editor at the Journal of General Physiology. He also teaches yoga at LifeTime Athletic.
  47. Tadatsugu Taniguchi

    Tadatsugu Taniguchi

    Research Center for Advanced Science and Technology, The University of Tokyo, Japan

    Tada Taniguchi is Professor Emeritus of The University of Tokyo and Advisor to the Office of President, working at the Research Center for Advanced Science and Technology of the University. He also served as Director of the Max Planck–The University of Tokyo Center for Integrative Inflammology from 2014 to 2018. He received his Ph.D. from the University of Zurich. His work principally concerns the mechanisms of signal transduction and gene expression that underlie immunity and oncogenesis. Many of his research projects have stemmed from his original discovery of two cytokine genes, interferon-beta and interleukin-2. These discoveries have laid the groundwork for the molecular characterization of the various systems of cytokines as well as therapeutic advances achieved by the administration of cytokines. One extension of this research was his discovery of a new family of transcription factors, the interferon regulatory factors (IRFs), which he and others have since identified as playing integral roles in the regulation of the immunity, inflammation and cancer. He has received numerous awards, including the Robert Koch Prize, Pezcoller-AACR International Award for Cancer Research, and was bestowed the Person of Cultural Merit award from the Government of Japan. He was also elected Foreign Associate Member of the National Academy of Sciences, USA, in 2003, International Member of the National Academy of Medicine in 2016 and Associate Member of EMBO in 2018.

    Expertise
    Immunology and Inflammation
    Research focus
    inflammation
    innate immunity
    adaptive immunity
    immunological disease
    anti-tumor immunity
    gene regulation in immune cells
    signaling in immune cells
    gene regulation in host defence
    Competing interests statement
    Tada Taniguchi has received funding from the Ministry of Education, Culture, Sports, Science & Technology, and Japan Agency for Medical Research and Development in Japan. He is a member of the editorial boards of Proceedings of the National Academy of Sciences, and Immunity. He is a member of the board of directors of the Japan Molecular Biology Society, and served as member of the Science Council of Japan between 2005 and 2011. He also served as co-chairperson of the International Affairs Committee of The American Association for Cancer Research between 2002 and 2008.
  48. Diethard Tautz

    Max-Planck Institute for Evolutionary Biology, Germany

    Diethard Tautz is since 2006 Director of the Department for Evolutionary Genetics at the Max-Planck Institute for Evolutionary Biology in Plön, Germany. He did his PhD at the EMBL in Heidelberg, followed by postdoc phases on molecular evolution in Cambridge (UK) and on the molecular analysis of developmental processes in Drosophila at the MPI for Developmental Biology in Tübingen, where he joined the group of Herbert Jäckle. In 1991 he became Professor in the Department of Zoology in Munich and in 1998 he moved to a chair in "Evolutionary Genetics" at the Department of Genetics of the University of Cologne. In his research, he combined his interests in molecular evolution and developmental biology, and was one of the founders of the emerging Evo-Devo field. In parallel, he worked on questions of behavioral ecology and speciation mechanisms, based on his discovery of microsatellite-based DNA fingerprinting. His current interests center around studying the genetics of adaptations, using wild populations of the house mouse as a model system. He is also continuing his work on molecular evolution, with a special emphasis on the de novo evolution of genes. He has served as Editor-in-Chief for Development, Genes and Evolution, and was a co-founder of the open-access journal Frontiers in Zoology.

    Expertise
    Evolutionary Biology
    Genetics and Genomics
    Research focus
    evolutionary genetics
    population genomics
    molecular evolution
    evolution of development
    comparative genomics
    adaptation
    behavioral ecology
    speciation
    Experimental organism
    mouse
    Competing interests statement
    Diethard Tautz is funded by the Max-Planck Society and the European Research Council. He currently serves as Senior Editor for Molecular Ecology and on the editorial board of Frontiers in Zoology, Development Genes and Evolution, and Briefings in Functional Genomics and Proteomics. He served on a number of Max-Planck committees and on the evaluation committees for academic institutions.
  49. Jessica Tyler

    Weill Cornell Medicine, United States

    Jessica Tyler was born in England in 1969. After graduating from the University of Sheffield with a Bachelors degree and the Hans Krebs Prize in Biochemistry, she performed her PhD studies at the MRC Virology Unit in Glasgow, Scotland. During her postdoctoral studies with Dr James Kadonaga at the University of California, San Diego, she identified the key chromatin assembly factors Anti-silencing Function 1 (Asf1) and characterized Chromatin Assembly Factor 1 (CAF-1) from Drosophila. In 2000, Dr Tyler started her first faculty position in the Department of Biochemistry and Molecular Genetics at the University of Colorado School of Medicine, Denver, USA. In the next 10 years, Dr Tyler revealed that chromatin assembly and disassembly not only regulates S phase events, but also gene expression and the DNA damage response. Dr Tyler was a Leukemia and Lymphoma Society Scholar and was awarded the Charlotte Friend Woman in Cancer Research Award for 2009 from the American Association of Cancer Research (AACR). Having risen rapidly to the rank of full professor at the University of Colorado, Dr Tyler moved in 2010 to the Department of Biochemistry and Molecular Biology at MD Anderson Cancer Center in Houston. Her recent work has extended to the broader influence of chromatin assembly on mitosis, aging and cancer. She is now in the Department of Epigenetics and Molecular Carcinogenesis, where she co-directs the Center for Cancer Epigenetics and holds the Edward Rotan Distinguished Professorship in Cancer Research. Her most proud achievement is being mother to 11 year-old triplets. In November 2015, she became a Professor in the Department of Pathology and Laboratory Medicine at Weill Cornell Medical College in New York.

    Expertise
    Chromosomes and Gene Expression
    Genetics and Genomics
    Research focus
    epigenetic regulation
    chromatin
    gene expression
    mitosis
    aging
    cancer
    Experimental organism
    S. cerevisiae
    Competing interests statement
    Previous funding has come from March of Dimes, Susan Komen, the Leukemia and Lymphoma Foundation, NIH, and CPRIT. Jessica Tyler serves on the editorial boards of Journal of Biological Chemistry, Molecular and Cellular Biology, and Chromatin and Epigenetics.
  50. K VijayRaghavan

    K VijayRaghavan

    National Centre for Biological Sciences, Tata Institute of Fundamental Research, India

    Vijay’s research aims to understand motor- and olfactory- circuit assembly: from deciphering how each component is made, interacts, and stabilises into functioning in the animal to allow behaviour in the real world. Related to the development of network function is its maintenance in the mature animal; another aspect of the work in the laboratory addresses how mature neurons and muscles are maintained. The laboratory uses a genetic approach, mainly using the fruit fly but also collaborating with those using mouse and cell-culture. VijayRaghavan is Secretary to the Government of India in the Ministry of Science and Technology in the Department of Biotechnology. He temporarily holds additional charge of the Department of Biotechnology. VijayRaghavan’s research continues at the National Centre for Biological Sciences (NCBS) of the Tata Institute of Fundamental Research (TIFR) in Bangalore, India, where he is Distinguished Professor. He studied engineering at the Indian Institute of Technology, Kanpur. His doctoral work was at TIFR, Mumbai and postdoctoral work at the California Institute of Technology. VijayRaghavan is a Fellow of the Royal Society, a Foreign Associate of the US National Academy of Sciences and a Foreign Associate of the European Molecular Biology Organization.

    Expertise
    Developmental Biology
    Chromosomes and Gene Expression
    Neuroscience
    Research focus
    genetics and genomics
    developmental biology
    neurogenetics
    neurobiology
    genetic basis of behavior
    Experimental organism
    D. melanogaster
    human
    mouse
    Competing interests statement
    K VijayRaghavan currently receives research support from the Indo–French research agency CEFIPRA, and core support from the National Centre for Biological Sciences (NCBS) of the Tata Institute of Fundamental Research (TIFR). Previous support was from the Rockefeller Foundation, the Wellcome Trust, the Indian Department of Science and Technology (DST), Department of Biotechnology (DBT), CEFIPRA, the Human Frontier Science Program (HFSP), and the US National Institutes of Health (NIH). VijayRaghavan serves on the Board of Governors of the Okinawa Institute of Science and Technology, is a member of the Advisory Committee of the Janelia Farm Research Campus of the HHMI, Chair of the Research Council of the Institute of Genomics and Integrative Biology, and Member of the Governing Council of the National Institute of Immunology. He is Associate Editor of BMC Developmental Biology, and a member of the editorial boards of Development, Seminars in Developmental Biology, and Bioconcepts. He is Chair of the Board of the Center for Cellular and Molecular Platforms (C-CAMP), a not-for-profit company of the National Centre for Biological Sciences and the stem cell institute, inStem, created to manage platform technologies and for technology transfer on the NCBS–inStem campus. He is a member of the board of the Madhuram Narayanan Centre for Exceptional Children, a not-for-profit school for disabled children in Chennai, and a member of the Board of Trustees of the Human Frontier Science Program.
  51. Aleksandra Walczak

    Ecole Normale Superieure, France

    Aleksandra Walczak received her PhD in physics at UCSD working on models of stochastic gene expression. After a graduate fellowship at KITP, she was a Princeton Center for Theoretical Science Fellow, focusing on applying information theory to signal processing in small gene regulatory networks. Currently she is a CNRS researcher at the Ecole Normale Superieure in Paris, interested in a variety of problems in the physics of living systems.

    She actively works on development, collective behavior of bird flocks and statistical descriptions of the immune system.

    Expertise
    Computational and Systems Biology
    Physics of Living Systems
    Research focus
    systems biology
    gene regulatory networks
    immune system
    population genetics
    Competing interests statement
    Aleksandra Walczak is the recipient of a CNRS-Chicago Cooperation Grant, a FACCTS CNRS-Chicago Cooperation Grant, an IRN CNRS Predictability, Adaptability Evolution network collaboration grant, a CNRS-MIT Cooperation Grant, a q-Life Grant "The physics of repair and silencing foci?, an ERC Proof of Concept Grant "Automated evaluation and correction of generation bias in immune receptor repertoires", a DFG CRC "Predictability in evolution", an ERC International Training Network QuanTII grant, and an ERC Consolidator Grant "Statistical physics of immune-viral co-evolution”.
  52. Kate Wassum

    University of California, Los Angeles, United States

    Kate is an Associate Professor of Behavioral Neuroscience in the Psychology Department at UCLA. Her research focuses on the neural signals and circuits underlying appetitive associative learning, motivated behavior, and decision making and how dysfunction in these mechanisms can produce the maladaptive behavior underlying mental illness. Her lab uses multidisciplinary approach, combining behavioral procedures rooted in the rich traditions of learning theory with advanced systems neuroscience and molecular methods.

    Expertise
    Neuroscience
    Research focus
    behavioural neuroscience
    systems neuroscience
    learning and memory
    motivation
    reward
    decision making
    addiction
    Experimental organism
    rat
    mouse
    Competing interests statement
    Kate Wassum currently receives funding from the National Institutes of Health. She is an associate editor at the Journal of Neuroscience, editorial board member at Neuropsychopharmacology, ACS Chemical Neuroscience, and Scientific Reports, and a consulting editor at Journal of Experimental Psychology Animal Learning & Cognition.
  53. Gary Westbrook

    Vollum Institute, United States

    Gary Westbrook is a Senior Scientist and Co-Director of the Vollum Institute and Rocky and Julie Dixon Professor of Neurology at Oregon Health and Science University. Dr Westbrook is a member of the National Academy of Medicine (formerly Institute of Medicine), the American Academy of Arts and Sciences, and past editor-in-chief of the Journal of Neuroscience. He has received Javits and Merit awards from NIH for his research as well as an International Cooperation Award from the Max Planck Society. Dr Westbrook received his medical training and did graduate study in Biomedical Engineering at Case Western Reserve University, followed by residencies in Internal Medicine and Neurology, and basic neuroscience research at the National Institutes of Health in Bethesda. Earlier work in his lab was mostly directed at the level of receptors, particularly N-methyl-D-aspartate (NMDA) receptors, and the function of single synapses. The emphasis has now largely shifted to studies of small networks (microcircuits) in the hippocampus and olfactory system. Dr Westbrook maintains interests in clinical neurology, particularly epilepsy, as well as graduate research training – he currently serves as the director of the Neuroscience Graduate Program at Vollum/OHSU.

    Expertise
    Neuroscience
    Research focus
    clinical neurology
    synaptic transmission
    olfactory system
    hippocampus
    neuroscience
    brain microcircuits
    neurological diseases
    Experimental organism
    mouse
    Competing interests statement
    Gary Westbrook is employed by Oregon Health and Science University. He receives research and training funding from the National Institutes of Health and the Ellison Medical Foundation. He is a member of the National Academy of Medicine (formerly Institute of Medicine) and the American Academy of Arts and Sciences. He serves on Scientific Advisory Boards for Max Planck Institutes in Göttingen (MPIEM) and Florida (MPFI), the Myelin Repair Foundation, and on study sections for the National Institutes of Health. He is currently a member of editorial boards for Physiological Reviews and Philosophical Transactions of the Royal Society B.
  54. Richard M White

    Memorial Sloan Kettering Cancer Center, United States

    Richard White, M.D., Ph.D, is a physician-scientist at the Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College. He is interested in basic mechanisms underlying metastasis, using the zebrafish as a model system. His work has established numerous techniques for cancer modeling and high-resolution imaging in the fish. Using these tools, the lab is focused on the cross-talk between tumor cells and the microenvironment, and how this interplay influences metastatic success. His work has revealed novel interactions between melanoma cells and adipocytes in the microenvironment, and how neural crest programs play roles in melanoma progression. He has been awarded the NIH Director’s New Innovator Award, the Pershing Square Foundation Award, and the Mark Foundation ASPIRE award.

    Expertise
    Cancer Biology
    Developmental Biology
    Research focus
    metastasis
    melanocyte development
    neural crest
    melanoma
    adipocytes
    microenvironment
    melanocytes
    Experimental organism
    zebrafish
    Competing interests statement
    Richard White receives funding from the National Institutes of Health, the Pershing Square Sohn Foundation, the Mark Foundation, the Melanoma Research Alliance, the American Cancer Society and the Harry J. Lloyd Foundation. He receives consulting fees from N-of-One, Inc.
  55. Patricia Wittkopp

    University of Michigan, United States

    Patricia Wittkopp received a BS from the University of Michigan, a PhD from the University of Wisconsin, and did postdoctoral work at Cornell University. In 2005, she began a faculty position at the University of Michigan, where she is now an Arthur F Thurnau Professor in the Department of Ecology and Evolutionary Biology, Department of Molecular, Cellular, and Developmental Biology, Center for Computational Medicine and Bioinformatics, and LSA Honors Program. Her research investigates the genetic basis of phenotypic evolution, with an emphasis on the evolution of gene expression. Molecular and developmental biology, population and quantitative genetics, genomics and bioinformatics are integrated in this work. She was a Damon Runyon Cancer Research Fellow, an Alfred P Sloan Research Fellow, and a recipient of a March of Dimes Starter Scholar Award.

    Expertise
    Computational and Systems Biology
    Ecology
    Genetics and Genomics
    Evolutionary Biology
    Research focus
    evolutionary genetics
    evolution and development
    gene expression
    regulatory networks
    allele-specific expression
    Experimental organism
    D. melanogaster
    S. cerevisiae
    Competing interests statement
    Patricia Wittkopp has received research support from the National Institutes of Health, National Science Foundation, March of Dimes, and the Alfred P Sloan Foundation. She is currently an Associate Editor of Molecular Biology and Evolution and Genome Biology and Evolution, and also serves on the Advisory Editorial Board of Trends in Genetics.
  56. Cynthia Wolberger

    Johns Hopkins University School of Medicine, United States

    Cynthia Wolberger is a Professor of Biophysics and Biophysical Chemistry at the Johns Hopkins University School of Medicine, whose faculty she joined in 1991. She received her AB in Physics from Cornell University and her PhD in Biophysics from Harvard University, where she did thesis work on the structural basis of protein-DNA interactions under the guidance of Steve Harrison and Mark Ptashne. After a postdoctoral fellowship at the University of California, San Francisco with Bob Stroud, she worked on the crystal structures of homeodomain-DNA complexes in the laboratory of Carl Pabo at Johns Hopkins. Her earlier worked focused on the structural basis for combinatorial regulation of gene expression and the molecular mechanisms of the sirtuin family of protein deacetylases. Her current research centers on the mechanisms by which ubiquitin plays a signaling role in transcription and the DNA damage response. Wolberger was a recipient of the David and Lucile Packard Fellowship for Science and Engineering, a March of Dimes–Basil O’Conor Starter Scholar Award, and an American Cancer Society Junior Faculty Award, and was a Howard Hughes Medical Institute Investigator from 1994–2014. She received the Protein Society’s Dorothy Crowfoot Hodgkin Award and is a Fellow of the American Association for the Advancement of Science.

    Expertise
    Structural Biology and Molecular Biophysics
    Chromosomes and Gene Expression
    Biochemistry and Chemical Biology
    Research focus
    x-ray crystallography
    enzymology
    transcriptional regulation
    ubiquitin signaling
    Competing interests statement
    Cynthia Wolberger receives funding from the National Institutes of Health and the US–Israel Binational Science Foundation. She chairs the Scientific Advisory Committee of the RCSB Protein Data Bank and is on the external scientific advisory boards of the Advanced Photon Source and the Max Planck Institute for Biochemistry in Martinsried, Germany. She is a member of the Editorial Advisory Board of Protein Science, the Editorial Boards of Structure and Current Opinion in Structural Biology, and is a Faculty of 1000 section head in Transcription and Translation. Wolberger is also a member of the Scientific Advisory Board of Thermo Fisher Scientific.
  57. Huda Zoghbi

    Huda Zoghbi

    Texas Children's Hospital, United States

    Huda Zoghbi is Professor of Pediatrics, Neurology, Molecular and Human Genetics, and Neuroscience at Baylor College of Medicine, Houston, Texas. She is also an Investigator with the Howard Hughes Medical Institute and Director of the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital. Her research focuses on understanding normal brain development and on elucidating the pathogenesis of several neurological disorders including the autism spectrum disorder, Rett syndrome, and late-onset neurodegenerative diseases.

    Expertise
    Human Biology and Medicine
    Neuroscience
    Research focus
    animal models of human disease and behavioural sciences
    neurodegenerative disorders
    polyglutamine disorders
    autism
    synaptic disorders
    neurogenetics
    Experimental organism
    human
    Competing interests statement
    Huda Zoghbi is actively receiving funds from the Howard Hughes Medical Institute, the National Institutes of Health, Rett Syndrome Research Trust, International Rett syndrome Foundation (and she is a member of advisory panels for all 4 organizations), Baylor College of Medicine, and Texas Children’s Hospital. She is Associate Editor of Annual Reviews of Neuroscience and a member of the editorial team of Cell and Neuron. She is Vice-Chair of the McKnight Neuroscience Fund and a member of the following Scientific Advisory Panels: the Jane Coffin Childs Fund, Gruber Genetics Prize Jury, Janssen Prize Jury, Lasker Jury, and Vilcek Prize Jury. She was an elected member at large of the 2015 Class Membership Committee of the National Academy of Sciences.

Founding Editor-in-Chief

  1. Randy Schekman

    Founding Editor-in-Chief, HHMI, University of California, Berkeley, United States

    Randy Schekman was awarded the 2013 Nobel Prize in Physiology or Medicine, with James Rothman and Thomas Sudhof. He is Professor of Molecular and Cell Biology at the University of California, Berkeley, and an Investigator at the Howard Hughes Medical Institute. His work concerns the mechanism of membrane assembly and vesicular traffic in eukaryotic cells. He and his laboratory discovered many of the genes and proteins required for secretion in yeast and they have applied this knowledge to understand human genetic diseases that affect core components of the secretory machinery. Among other awards, he shared the Gairdner International Award, the Louisa Gross Horwitz Prize and the Lasker Award with James Rothman. A member of the American Academy of Arts and Sciences, the American Philosophical Society and the National Academy of Sciences, he was elected President of the American Society for Cell Biology in 1999 and served as Editor-in-Chief of the Proceedings of the National Academy of Sciences from 2006 to late 2011.

    Expertise
    Cell Biology
    Research focus
    membrane assembly
    vesicular trafficking
    protein transport
    animal and human cell biology
    Experimental organism
    S. cerevisiae