For the press

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1. 1. Human Biology and Medicine

   Rare, damaging inherited mutations work together to reduce lifespan

   New findings suggest our risk of long-term diseases and overall lifespan are influenced by the combined effect of rare mutations that are already present at birth.

2. Media Coverage: March roundup of eLife papers in the news

   High-profile news coverage that eLife papers generated in March 2020, including The New York Times, Daily Mail and Forbes.
3. 1. Neuroscience

   Study suggests suicide attempt survivors have lower sensitivity to bodily signals

   New findings identify physical differences between people who have attempted suicide and those who have not, paving the way for future studies on biological factors that may predict suicide risk.
4. 1. Evolutionary Biology
   2. Plant Biology

   How wallflowers evolved a complementary pair of plant defences

   New findings show that a pair of complementary chemical defences evolved independently in wallflowers, shaped by co-evolution with local insects.
5. 1. Developmental Biology
   2. Neuroscience

   Amyloid formation drives brain tissue loss in animal studies

   New findings show that the formation of amyloid plaques drives damage and tissue loss in the brain during Alzheimer’s disease in animals, but lithium reduces the life-shortening effects of this loss.
6. 1. Cancer Biology

   Novel cell-based cancer immunotherapy shows promise in early studies

   A new cell therapy is effective in human and mouse models and reveals the potential of using mouse tumour models in evaluating the effectiveness, safety and mechanisms of this type of treatment.
7. 1. Neuroscience

   Visual feedback enhances activation of muscle movement in response to bodily sensation

   Scientists provide new insight on how the brain uses multiple sources of sensory information, including our vision and posture, to control movement.
8. 1. Structural Biology and Molecular Biophysics

   Ultrabright X-ray bursts reveal how plants respond to light within fraction of a second

   Scientists have revealed intricate structural changes within protein molecules called phytochromes to show how plants and bacteria perceive light.
9. 1. Chromosomes and Gene Expression
   2. Biochemistry and Chemical Biology

   Scientists reveal how proteins team up to repair DNA

   New insight on DNA repair in yeast adds to our understanding of why DNA repair processes fail to function properly in disease.
10. 1. Neuroscience

    Scientists shed new light on neural basis of tremors

    New findings suggest that abnormal signalling by Purkinje cells in the brain causes tremors, but a technique called cerebellar deep brain stimulation can help treat this condition.