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    1. Cancer Biology

    Low-dose, four-drug combo blocks cancer spread in mice

    A new approach to preventing cancer spread that uses a combination of low-dose, metastasis-inhibiting drugs shows promise in mouse studies and may help prevent drug resistance or relapse.
    1. Computational and Systems Biology
    2. Medicine

    Map of metabolic changes after heart attack holds clues to recovery

    Researchers have constructed a map of metabolic changes that occur across multiple tissues after a heart attack in the hope of finding targets for better treatments.

  3. Media Coverage: April roundup of eLife papers in the news

    High-profile news coverage that eLife papers generated in April 2021, including Scientific American, the Daily Mail and the Hindustan Times.
    1. Computational and Systems Biology
    2. Medicine

    Why does heart scarring cause abnormal rhythms in some people but not others?

    People with stroke without atrial fibrillation have the same heart scar tissue as those with atrial fibrillation but may be lacking the triggers that cause heart rhythm disorders.
    1. Computational and Systems Biology

    Changes in proteins play important role in aging kidneys

    Researchers have shown that examining both protein changes and the transcription of genes in kidneys provides a more complete picture of the aging process in these organs.
    1. Genetics and Genomics

    Do people aged 105 and over live longer because they have more efficient DNA repair?

    Whole-genome sequencing of people who live beyond 105 and 110 years reveals unique genetic signatures linked to protective processes such as DNA repair.
    1. Medicine
    2. Neuroscience

    Researchers find mechanism underlying muscle weakness in Becker disease

    Study identifies the mechanisms that cause muscle weakness experienced by people with Becker disease, providing options for possible new therapies.
    1. Epidemiology and Global Health
    2. Medicine

    Study reports links between blood types and disease risks

    A scan of health data on more than five million people for links between blood type and more than 1,000 diseases reveals new connections and supports previously reported ones.
    1. Immunology and Inflammation
    2. Medicine

    Overgrowth of gut yeast in newborns may increase asthma risk

    Trans-kingdom imbalances in the gut microbes of newborns may increase the risk of asthma later in life, providing a possible target for treating the condition.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Study reveals roadmap of muscle decline with age

    A comprehensive roadmap of muscle decline with age in mice reveals possible new targets for treatments, including the molecule Klotho.
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