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    1. Immunology and Inflammation

    Study reveals negative consequences of trained immunity in the lungs

    A compound found in fungal cell walls can reprogram immune cells in the lungs, potentially worsening inflammation during infections.
    1. Neuroscience

    Scientists reveal neural mechanism that could lead to better pain relief

    A study in mice has unpicked the neuronal circuitry responsible for pain suppression in threatening situations, pointing towards better pain relief treatments.
    1. Microbiology and Infectious Disease

    New RNA test for African trypanosomiasis in livestock aids control efforts

    A new state-of-the-art diagnostic test for animal African trypanosomiasis could detect sentinels of infection in domestic animals and aid control efforts.
    1. Microbiology and Infectious Disease
    2. Evolutionary Biology

    Large-scale immunity profiling grants insights into flu virus evolution

    Researchers have used high-throughput neutralisation assays to reveal how gaps in individual immunity shape the success of circulating flu strains.

  5. Media Coverage: April roundup of eLife papers in the news

    High-profile news coverage that eLife papers generated in April 2025, including Popular Science, Daily Express and LiveScience.
    1. Neuroscience

    Targeting single gene may reverse cognitive deficits in 22q11.2 Deletion Syndrome

    A new study has shown that lowering levels of a protein called EMC10 can restore brain function and memory in models of 22q11.2 Deletion Syndrome, pointing to a potential treatment approach.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Study reveals intricate molecular detail of human DNA repair process

    Researchers have revealed the fundamental mechanisms underlying homologous recombination – one of the main DNA repair pathways in human cells.
    1. Epidemiology and Global Health

    Asymptomatic transmission may explain resurgence of whooping cough

    A new study of mothers and infants in Lusaka, Zambia, reveals that people without symptoms can still spread pertussis (or whooping cough), highlighting the need for better disease surveillance.
    1. Neuroscience

    New fruit fly resource reveals nerve circuits that control flight and courtship

    Researchers have created a library of genetically engineered fruit flies linked to individual neurons in the nerve cord to characterise the circuits controlling wing motion.

  10. eLife named among winners of inaugural Crossref Metadata Excellence Awards

    eLife has been announced as a winner in the first Crossref Metadata Awards, recognising its commitment to high-quality metadata in the research it publishes.
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