Latest research

1. 1. Developmental Biology
   2. Neuroscience

   Comprehensive transcriptome analysis of cochlear spiral ganglion neurons at multiple ages

   Chao Li et al.

   RNA-Seq analysis and in vivo validation via genetic approach uncover that Scrt2 and Celf4 are expressed in inner ear auditory neurons throughout development.
2. 1. Microbiology and Infectious Disease

   Homeostatic control of cell wall hydrolysis by the WalRK two-component signaling pathway in Bacillus subtilis

   Genevieve S Dobihal et al.

   Molecular genetic analyses define the first homeostatic control pathway that maintains cell wall remodeling activity during bacterial growth.
3. 1. Developmental Biology

   Lola regulates Drosophila adult midgut homeostasis via non-canonical hippo signaling

   Xue Hao et al.

   The transcription factor Lola is defined as a non-canonical Hippo signaling component essential for Drosophila midgut homeostasis via its interaction with Warts and suppression on Dref and SkpA expression levels.
4. 1. Human Biology and Medicine

   Ankyrin-G mediates targeting of both Na⁺ and K_ATP channels to the rat cardiac intercalated disc

   Hua-Qian Yang et al.

   The functional interaction of Na⁺ and K_ATP channels at the intercalated disk of cardiomyocytes depends on Ankyrin G and is clinically relevant since K_ATP channel mutations affect Na⁺ channel expression.
5. 1. Cancer Biology
   2. Human Biology and Medicine

   PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis

   Norihiro Yamaguchi et al.

   The gluconeogenic enzyme PCK1 and pyrimidine nucleotide biosynthetic enzyme DHODH drive hypoxic pyrimidine nucleotide biosynthesis and liver metastatic colonization in colorectal cancer, which is therapeutically exploitable by DHODH pharmacologic inhibition.
6. 1. Structural Biology and Molecular Biophysics

   Two forms of Opa1 cooperate to complete fusion of the mitochondrial inner-membrane

   Yifan Ge et al.

   An in vitro reconstitution assay reveals stoichiometric levels of the short form of Opa1 work together with the long form of Opa1 to mediate efficient and fast membrane pore opening.
7. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in C. elegans

   Teresa Wei-sy Lee et al.

   The transgenerational inheritance of lifespan is facilitated by the accumulation of repressive chromatin across generations.
8. 1. Structural Biology and Molecular Biophysics

   Molecular basis of force-from-lipids gating in the mechanosensitive channel MscS

   Bharat Reddy et al.

   The structure of the mechanosensitive channel MscS embedded in a lipid bilayer redefines the nature, location and importance of lipid–protein interactions in the gating of mechanosensitive channels.
9. 1. Cell Biology
   2. Computational and Systems Biology

   A regulatory microRNA network controls endothelial cell phenotypic switch during sprouting angiogenesis

   Stefania Rosano et al.

   Coordinated microRNAs activity induced by VEGF represses cell proliferation and favors cell migration at the onset of sprouting angiogenesis in endothelial cells.
10. 1. Human Biology and Medicine
    2. Neuroscience

    Human hippocampal CA3 damage disrupts both recent and remote episodic memories

    Thomas D Miller et al.

    Human hippocampal cornu ammonis 3 damage impairs both recent and remote autobiographical episodic memory, and disrupts functional integration in medial temporal lobe subsystem regions of the default network.