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Latest research

1. 1. Chromosomes and Gene Expression
   2. Immunology and Inflammation

   Maternal obesity blunts antimicrobial responses in fetal monocytes

   Suhas Sureshchandra, Brianna M Doratt ... Ilhem Messaoudi

   Maternal obesity and high-fat diet present metabolic, signaling, and epigenetic impediments to pathogen recognition in fetal innate immune cells that result in a state of immune paralysis during gestation and at birth.
2. 1. Physics of Living Systems

   Dynamics of cooperative excavation in ant and robot collectives

   S Ganga Prasath, Souvik Mandal ... L Mahadevan

   Observations of ant excavation from a confining corral, along with theoretical models and synthetic robot experiments show the emergence of cooperation induced by pheromones in a malleable environment that is moulded by and moulds collective behavior.
3. 1. Epidemiology and Global Health
   2. Microbiology and Infectious Disease

   Future COVID19 surges prediction based on SARS-CoV-2 mutations surveillance

   Fares Z Najar, Evan Linde ... Pratul K Agarwal

   A real-time genomic surveillance approach based on mutation analysis of SARS-CoV-2 proteins has enabled a priori prediction of surge in number of COVID19 infection cases, including those already observed in July and September 2022.
4. 1. Cancer Biology

   Arginase 1 is a key driver of immune suppression in pancreatic cancer

   Rosa Elena Menjivar, Zeribe C Nwosu ... Marina Pasca di Magliano
5. 1. Neuroscience

   Pallidal neuromodulation of the explore/exploit trade-off in decision-making

   Ana Luisa de A. Marcelino, Owen Gray ... Tom Gilbertson
6. 1. Cell Biology
   2. Neuroscience

   Synaptic vesicle proteins are selectively delivered to axons in mammalian neurons

   Emma T Watson, Michaela M Pauers ... Edwin R Chapman

   Using carefully controlled expression levels and a variety of optical pulse-chase assays in mammalian neurons, an updated model for the polarized transport of synaptic vesicle proteins, and the first steps of synaptic vesicle biogenesis, were uncovered.
7. 1. Neuroscience

   Successor-like representation guides the prediction of future events in human visual cortex and hippocampus

   Matthias Ekman, Sarah Kusch, Floris P de Lange

   Early visual cortex (V1) and hippocampal cortex represent a predictive map of the visual world akin to the successor representation.
8. 1. Epidemiology and Global Health
   2. Genetics and Genomics

   Smoking, Alcohol consumption, and 24 Gastrointestinal Diseases: Mendelian Randomization Analysis

   Shuai Yuan, Jie Chen ... Susanna C Larsson
9. 1. Neuroscience

   GluA3 subunits are required for appropriate assembly of AMPAR GluA2 and GluA4 subunits on cochlear afferent synapses and for presynaptic ribbon modiolar–pillar morphology

   Mark A Rutherford, Atri Bhattacharyya ... Maria Eulalia Rubio

   Ultrastructural and imaging studies of cochlear ribbon synapses demonstrate cis- and trans-synaptic molecular and structural effects in the absence of the AMPA-type glutamate receptor subunit GluA3 during mouse development in ambient sound levels.
10. 1. Immunology and Inflammation

    T follicular helper 17 (Tfh17) cells are superior for immunological memory maintenance

    Xin Gao, Kaiming Luo ... Di Yu

    By comparing different subsets in mouse inducible Tfh (iTfh) cells and human circulating Tfh (cTfh) cells after vaccination, Tfh17 cells were found to be better than Tfh1 or Tfh2 cells in maintenance and support immunological memory of humoral immunity.