Highlights

  • Getting to grips with touch

    Experiments on duck cells reveal how forces on the skin are converted into electrical signals in sensory neurons. Photo: Bagriantsev Laboratory

    Luke H Ziolkowski, Elena O Gracheva, Sviatoslav N Bagriantsev
    Short Report Updated
  • Brain injury and aging

    Studies of transcription reveal how traumatic brain injury and aging influence cell composition and gene expression in the meninges.

    Ashley C Bolte, Daniel A Shapiro ... John R Lukens
    Tools and Resources
  • eLife Board of Directors

    eLife is pleased to welcome four new members to its Board of Directors, which helps to direct the organization in its mission to transform research communication.

    Inside eLife

Latest research

    1. Structural Biology and Molecular Biophysics

    A mechanism of uncompetitive inhibition of the serotonin transporter

    Shreyas Bhat, Ali El-Kasaby ... Walter Sandtner
    Biochemical and electrophysiological approaches show that the amphetamine derivative ECSI#6 is an uncompetitive inhibitor of the serotonin transporter and thus the first ever characterized ligand of a solute carrier of this type.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanism of Ca2+ transport by ferroportin

    Jiemin Shen, Azaan Saalim Wilbon ... Yaping Pan
    Cryo-EM structure and functional analyses show that human iron exporter ferroportin (Fpn) can bind and transport calcium ions and the transport activity is reduced when the concentration of ferrous ions is high.
    1. Medicine

    Phenome-wide Mendelian randomisation analysis identifies causal factors for age-related macular degeneration

    Thomas H Julian, Johnathan Cooper-Knock ... Panagiotis I Sergouniotis
    A phenome-wide Mendelian randomisation analysis revealed a causal link between age-related macular degeneration and a number of lipid, complement, immune cell, and serum protein traits, highlighting potential treatment targets.
    1. Neuroscience
    2. Physics of Living Systems

    Scale-free behavioral dynamics directly linked with scale-free cortical dynamics

    Sabrina A Jones, Jacob H Barfield ... Woodrow L Shew
    1. Evolutionary Biology

    Mammalian forelimb evolution is driven by uneven proximal-to-distal morphological diversity

    Priscila S Rothier, Anne-Claire Fabre ... Anthony Herrel
    1. Neuroscience

    Signal denoising through topographic modularity of neural circuits

    Barna Zajzon, David Dahmen ... Renato Duarte