Axon growth in organoids

Latest research

1. 1. Neuroscience

   Prolonged nicotine exposure reduces aversion to the drug in mice by altering nicotinic transmission in the interpeduncular nucleus

   Sarah Mondoloni, Claire Nguyen ... Alexandre Mourot

   Inter-individual variabilities in nicotine aversion are linked with responses of the interpeduncular nucleus to the drug.
2. 1. Neuroscience

   Are single-peaked tuning curves tuned for speed rather than accuracy?

   Movitz Lenninger, Mikael Skoglund ... Arvind Kumar

   Single-peaked tuning curves found in early sensory areas are more optimized for quick decoding than accuracy, while multi-peaked tuning curves (e.g. grid cells) give higher accuracy but only at longer time scales.
3. 1. Genetics and Genomics
   2. Neuroscience

   Tau polarizes an aging transcriptional signature to excitatory neurons and glia

   Timothy Wu, Jennifer M Deger ... Joshua M Shulman

   While tau and aging have highly overlapping differential gene expression signatures, they diverge in the affected cell types, with aging having a wide-ranging impact and tau-triggered changes instead polarized to excitatory neurons and glia.
4. 1. Microbiology and Infectious Disease
   2. Physics of Living Systems

   Substrate stiffness impacts early biofilm formation by modulating Pseudomonas aeruginosa twitching motility

   Sofia Gomez, Lionel Bureau ... Sigolene Lecuyer

   The spatial organization of pathogenic bacteria into microcolonies can be shaped by the stiffness of the substrate that they colonize, via modifications of the bacterial motility.
5. 1. Cell Biology

   Global analysis of contact-dependent human-to-mouse intercellular mRNA and lncRNA transfer in cell culture

   Sandipan Dasgupta, Daniella Y Dayagi ... Jeffrey E Gerst

   The RNA transferome comprises full-length mRNAs and lncRNAs that undergo non-selective and expression-dependent transfer between mammalian cells in culture via actin-based tunneling nanotubes.
6. 1. Neuroscience

   Cortico-thalamo-cortical interactions modulate electrically evoked EEG responses in mice

   Leslie D. Claar, Irene Rembado ... Christof Koch
7. 1. Neuroscience

   Approach-avoidance reinforcement learning as a translational and computational model of anxiety-related avoidance

   Yumeya Yamamori, Oliver J Robinson, Jonathan P Roiser
8. 1. Neuroscience

   Multiple dynamic interactions from basal ganglia direct and indirect pathways mediate action selection

   Hao Li, Xin Jin
9. 1. Genetics and Genomics

   Comprehensive mutagenesis maps the effect of all single codon mutations in the AAV2 rep gene on AAV production

   Nina K. Jain, Pierce J. Ogden, George M. Church
10. 1. Evolutionary Biology
    2. Genetics and Genomics

    Native American genetic ancestry and pigmentation allele contributions to skin color in a caribbean population

    Khai C Ang, Victor A Canfield ... Keith C Cheng