Latest research

    1. Structural Biology and Molecular Biophysics

    Sublytic gasdermin-D pores captured in atomistic molecular simulations

    Stefan L Schaefer, Gerhard Hummer
    Molecular dynamics simulations reveal the formation of membrane pores by gasdermin-D, the ultimate effector of pyroptotic cell death in inflammation and infection.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Chronic Ca2+ imaging of cortical neurons with long-term expression of GCaMP-X

    Jinli Geng, Yingjun Tang ... Xiaodong Liu
    Focusing on calcium oscillations in relation to neuronal morphology both in vitro and in vivo, rationally designed GCaMP-X provides a simple solution to neuronal toxicity of conventional GCaMP in imaging applications involving prolonged and/or strong expression of calcium probes.
    1. Neuroscience

    Dorsal striatum coding for the timely execution of action sequences

    Maria Cecilia Martinez, Camila Lidia Zold ... Mariano Andrés Belluscio
    In adolescent rats, whose actions are more impulsive, neuronal striatal activity that precedes self-initiated action sequences has a steeper modulation by waiting time compared to the modulation found in adults.
    1. Immunology and Inflammation

    Cell-intrinsic ceramides determine T cell function during melanoma progression

    Matthias Hose, Anne Günther ... Wiebke Hansen
    Cell-intrinsic ceramide concentrations are involved in T cell differentiation and function.
    1. Cancer Biology
    2. Medicine

    Non-coding RNAs in drug and radiation resistance of bone and soft-tissue sarcoma: a systematic review

    Huan-Huan Chen, Tie-Ning Zhang ... Tao Zhang
    Non-coding RNAs appear to be good candidates as biomarkers for predicting treatment response and therapeutics for sarcoma, their differential expression across tissues complicates their application.
    1. Computational and Systems Biology
    2. Neuroscience

    Self-configuring feedback loops for sensorimotor control

    Sergio Oscar Verduzco-Flores, Erik De Schutter
    Learning to reach in the sensorimotor loop, and the required neural dynamics, can be potentially explained by simple principles.
    1. Neuroscience

    Fast rule switching and slow rule updating in a perceptual categorization task

    Flora Bouchacourt, Sina Tafazoli ... Nathaniel D Daw
    Flexible cognition relies on a combination of fast inferential learning and slow incremental learning.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Reevaluation of Piezo1 as a gut RNA sensor

    Alec R Nickolls, Gabrielle S O'Brien ... Alexander T Chesler
    Piezo1 ion channels are not modulated by RNA ligands, contrary to previous findings.
    1. Neuroscience

    Robust group- but limited individual-level (longitudinal) reliability and insights into cross-phases response prediction of conditioned fear

    Maren Klingelhöfer-Jens, Mana R Ehlers ... Tina B Lonsdorf
    Reliability and predictability analyses beyond standard measures provide empirically based guidance regarding the design of fear conditioning tasks to assess individual differences and group-level inferences cross-sectionally and longitudinally.