eLife is an open-access journal that publishes promising research in the life and biomedical sciences

Latest research

    1. Neuroscience

    A zebrafish and mouse model for selective pruritus via direct activation of TRPA1

    Kali Esancy et al.
    A pain-relaying ion channel on a hypersensitive population of sensory neurons can instead elicit sensations of itch in both fish and mice when directly activated, providing a novel model of itch transduction.
    1. Biochemistry and Chemical Biology

    Tandem riboswitches form a natural Boolean logic gate to control purine metabolism in bacteria

    Madeline E Sherlock et al.
    A riboswitch class has been discovered for phosphoribosyl pyrophosphate, the biochemical precursor of nucleotides, and this novel RNA sensor commonly operates in tandem with a guanine aptamer to function like a Boolean logic gate.
    1. Neuroscience

    Optical detection of three modes of endocytosis at hippocampal synapses

    Natali L Chanaday, Ege T Kavalali
    1. Plant Biology

    A tension-adhesion feedback loop in plant epidermis

    Stéphane Verger et al.
    1. Neuroscience

    Structural and functional properties of a probabilistic model of neuronal connectivity in a simple locomotor network

    Andrea Ferrario et al.
    A new probabilistic model of connectivity reveals the structural and functional properties of the neural networks controlling locomotion in many individual tadpoles.
    1. Genomics and Evolutionary Biology
    2. Microbiology and Infectious Disease

    Mapping mutational effects along the evolutionary landscape of HIV envelope

    Hugh K Haddox et al.
    Deep mutational scanning of Env proteins from two transmitted-founder strains of HIV shows how the accessible evolutionary space changes as the virus evolves.