Highlights

  • Closing the neural tube

    High-throughput arrayed CRISPR interference screening of organoid models gives insight into genetic regulators of neural tube closure in humans.

    Roya E Huang, Giridhar M Anand ... Sharad Ramanathan
    Research Article

  • Evolution in eutherian mammals

    Following the end-Cretaceous extinction, eutherian mammals in China evolved larger teeth before developing more specialised biting adaptations.

    Z Jack Tseng, Qian Li, Suyin Ting
    Research Article

  • Insights into synaptic dysfunction

    LRRK2, a protein linked to Parkinson’s disease, interacts with an actin-binding protein, drebrin, to regulate synaptic function and has a role in BDNF-dependent synaptic modulation.

    Giulia Tombesi, Shiva Kompella ... Elisa Greggio
    Reviewed Preprint Updated

  • Publish-review-curate at eLife

    eLife is rethinking how research is reviewed and published.

    Timothy E Behrens, Yamini Dalal, Diane M Harper
    Editorial

  • Modulating hyperexcitability

    PRRT2, a transmembrane protein, helps to limit neuronal hyperexcitability by modulating slow inactivation of voltage-gated sodium channels.

    Bin Lu, Qi-Wu Xu ... Zhi-Qi Xiong
    Reviewed Preprint Updated

  • Science under threat

    How should the scientific community respond to ideological attacks on science?

    Humberto J Debat
    Feature Article
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Neuroscience

    The openretina Project: Collaborative Retina Modelling Across Datasets and Species

    Federico D’Agostino, Thomas Zenkel ... Matthias Bethge
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in cancer

    Qian Wang, Liping Li ... Chuo Chen
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A mitochondrial quality control mechanism reverses the phagosome maturation arrest caused by Mycobacterium tuberculosis

    Surbhi Verma, Shweta Thakur ... Dhiraj Kumar
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology

    Comparative single-cell transcriptomic roadmap of mammalian fetal ovarian development

    Yifei Fang, Shiyao Han ... Jingyue Ellie Duan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology

    Opto-MDMi: a dual-lock optogenetic system for robust activation of endogenous p53

    Tatsuki Tsuruoka, Takashi Sumikama ... Kazuhiro Aoki
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Developmental Biology

    Single-cell characterization of anterior segment development in the mouse reveals the cell types, pathways, and signals driving formation of the trabecular meshwork and Schlemm’s canal

    Revathi Balasubramanian, Nicholas Tolman ... Simon WM John
    High-resolution single-cell transcriptomics reveals the molecular programs and signaling networks driving Schlemm's canal and trabecular meshwork development, establishing a foundation for understanding glaucoma pathogenesis.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The adaptive landscapes of three global Escherichia coli transcriptional regulators

    Cauã Antunes Westmann, Leander Goldbach, Andreas Wagner
    Across three global Escherichia coli regulators, identical starting sequences can evolve toward many distinct strong-binding peaks, with chance, historical contingency, and evolutionary bias shaping which outcomes prevail.
    1. Microbiology and Infectious Disease

    Reactive oxygen detoxification contributes to Mycobacterium abscessus antibiotic survival

    Nicholas A Bates, Ronald Rodriguez ... Bennett H Penn
    Antibiotics that inhibit translation cause a burst in reactive oxygen species, and these must be detoxified by factors such as KatG for cells to survive.
    1. Computational and Systems Biology
    2. Developmental Biology

    Quantitative computerized analysis demonstrates strongly compartmentalized tissue deformation patterns underlying mammalian heart tube formation

    Morena Raiola, Miquel Sendra Sendra ... Miguel Torres
    A computational pipeline leverages mammalian heart development videos to extract tissue deformation patterns and generate a virtual fate map tool that provides new insights into cardiac morphogenesis.
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Germline-somatic residue synergy reshapes antibody encounter-state pathways to enhance HIV-1 recognition

    Sangita Kachhap, Yishak Bililign ... Rory Henderson
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
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Magazine

    1. Cancer Biology

    Tumor Biology: The two faces of JAK-STAT

    Qianying Lu, Yingyi Zhang
    1. Neuroscience

    Brain Mapping: Understanding the cellular architecture of Huntington’s disease

    Dorian Pustina
    1. Physics of Living Systems

    Vector Biology: The exquisite mechanics of a tsetse bite

    Katelyn Fealy, Álvaro Acosta-Serrano
    1. Physics of Living Systems

    Actin Filaments: Building bundles by the numbers

    Christian Vanhille-Campos, Anđela Šarić
    1. Neuroscience

    Hippocampal Network: Stronger memories through smarter stimulation

    Justin Riddle
    1. Neuroscience

    Verbal Memory: Language acquisition in newborns

    Marcela Peña

  7. Episode 103: May 2026

  8. See more Magazine articles

Categories

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  10. Genetics and Genomics
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