Latest research

1. 1. Cell Biology

   One-shot analysis of translated mammalian lncRNAs with AHARIBO

   Luca Minati et al.

   Detection of translated lncRNAs through selective isolation of active ribosomes, ribosome-associated RNAs and corresponding de novo synthesised peptides.
2. 1. Developmental Biology
   2. Evolutionary Biology

   Developmental hourglass and heterochronic shifts in fin and limb development

   Koh Onimaru et al.

   Omics approaches reveal conserved and diversified gene regulation between fin and limb development.
3. 1. Cell Biology
   2. Computational and Systems Biology

   Identifying molecular features that are associated with biological function of intrinsically disordered protein regions

   Taraneh Zarin et al.

   A statistical model systematically associates functions of intrinsically disordered regions with sequence-distributed molecular features such as charge, residue composition, or repeat content.
4. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets

   Palur V Raghuvamsi et al.

   SARS-CoV-2 spike protein binding to receptor angiotensin-converting enzyme 2 allosterically enhances furin proteolysis at distal S1/S2 cleavage sites.
5. 1. Developmental Biology
   2. Genetics and Genomics

   Precise base editing for the in vivo study of developmental signaling and human pathologies in zebrafish

   Marion Rosello et al.

   Base editors, with improved specificity and expanded PAM sequence recognition, can be used in zebrafish for the rapid and efficient introduction of single base pair mutations.
6. 1. Neuroscience

   Drosophila uses a tripod gait across all walking speeds, and the geometry of the tripod is important for speed control

   Chanwoo Chun et al.

   Drosophila uses a gait close to the tripod throughout its speed range, and changes in speed are accompanied by changes in the geometry of the tripod.
7. 1. Chromosomes and Gene Expression

   Cohesin architecture and clustering in vivo

   Siheng Xiang, Douglas Koshland

   Cohesin adopts a flexible butterfly conformation in vivo and forms spatial and temporal regulated ordered clusters to maintain cohesion and condensation.
8. 1. Developmental Biology

   EKLF/KLF1 expression defines a unique macrophage subset during mouse erythropoiesis

   Kaustav Mukherjee et al.

   Mouse fetal liver macrophages that support erythroid differentiation within erythroblastic islands exhibit a unique and transient expression signature under transcriptional control of EKLF/KLF1.
9. 1. Biochemistry and Chemical Biology
   2. Neuroscience

   Phasic oxygen dynamics confounds fast choline-sensitive biosensor signals in the brain of behaving rodents

   Ricardo M Santos, Anton Sirota

   Fast fluctuations of oxygen, linked to behavioral and neural dynamics in vivo, cause phasic transients is amperometry-measured cholinergic signals via the mechanism of non-steady-state enzyme kinetics in the choline-oxidase-based biosensor.
10. 1. Cell Biology
    2. Physics of Living Systems

    Non-genetic inheritance restraint of cell-to-cell variation

    Harsh Vashistha et al.

    Quantitative measurement of epigenetic memory and inheritance dynamics.