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Latest research

    1. Evolutionary Biology

    Wings and halteres act as coupled dual oscillators in flies

    Tanvi Deora et al.
    Flight system of flies is driven by wings and mechanosensory halteres that operate as independently driven but coupled oscillators, thereby imparting robustness against wing or thorax damage.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts

    Calvin Jon A Leonen et al.
    Chemically sumoylated histone H4 shows negative biochemical crosstalk with gene-activating histone acetylation and methylation marks, and directly inhibits RNA polymerase II-mediated gene transcription.
    1. Neuroscience

    A parameter-free statistical test for neuronal responsiveness

    Jorrit S Montijn et al.
    A simple and robust statistical test for neuronal stimulus response, that outperforms PSTH-based approaches such as t-tests and ANOVAs.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Rapid and sensitive detection of SARS-CoV-2 infection using quantitative peptide enrichment LC-MS analysis

    Andreas Hober et al.
    Immuno-affinity enrichment combined with liquid chromatography-mass spectrometry can be used to detect viral proteins to confirm the presence of SARS-CoV-2 in clinical samples.
    1. Neuroscience

    Whole-brain connectivity atlas of glutamatergic and GABAergic neurons in the mouse dorsal and median raphe nuclei

    Zhengchao Xu et al.
    Whole-brain quantitative input-output circuits of glutamatergic and GABAergic neurons in the mouse dorsal and median raphe nuclei were mapped using viral tracing and high-resolution optical imaging.
    1. Neuroscience

    A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior

    Shankar Ramachandran et al.
    Investigation of neuromodulatory control of ethologically conserved area-restricted food search behavior shows that NLP-12 stimulation of the head motor circuit promotes food searching through the previously uncharacterized CKR-1 GPCR.
    1. Neuroscience

    Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons

    Minh Q Nguyen et al.
    Single-nucleus transcriptomics exposes unique features of human somatosensory neurons and clues that may help resolve repeated problems in translating new experimental approaches for treating pain.
    1. Neuroscience

    Metabolomic profiling reveals a differential role for hippocampal glutathione reductase in infantile memory formation

    Benjamin Bessières et al.
    Hippocampal metabolomic analyses following episodic learning at different ages revealed a critical role for neuronal glutathione reductase activity in long-term infantile memory formation.
    1. Neuroscience

    Attention network modulation via tRNS correlates with attention gain

    Federica Contò et al.
    Parietal noninvasive brain stimulation during perceptual training causes a dramatic increase in learning that correlates with network-wide changes in functional connectivity, demonstrating the stimulation-induced physiological mechanisms leading to cognitive benefits.
    1. Cell Biology

    Proximity labeling identifies LOTUS domain proteins that promote the formation of perinuclear germ granules in C. elegans

    Ian F Price et al.
    A proximity labeling approach defines germ granule proteome in Caenorhabditis elegans, and identifies LOTUS domain proteins as key regulators of germ granule assembly.