Highlights

  • Impaired spermatogenesis

    Mice deficient in a mitochondrial protease called PARL suffer from arrested spermatogenesis and a form of cell death called ferroptosis.

    Enrico Radaelli, Charles-Antoine Assenmacher ... Marco Spinazzi
    Research Article Updated
  • How ART impacts CD8+ T cells

    Exploring the impact of long-term antiretroviral treatment on the CD8+ T-cell landscape in people living with HIV-1.

    Oscar Blanch-Lombarte, Dan Ouchi ... Julia G Prado
    Research Article
  • Update on eLife’s new model

    Analysis of first six months show that submissions to new model have been steady and proportion sent for review is similar to old model.

    Inside eLife

Latest research

    1. Computational and Systems Biology
    2. Genetics and Genomics

    Systems level identification of a matrisome-associated macrophage polarisation state in multi-organ fibrosis

    John F Ouyang, Kunal Mishra ... Jacques Behmoaras
    A meta-analysis of single-cell data reveals an advanced and conserved polarisation state of SPP1+ macrophages in multiple human fibrotic tissues.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A cell wall synthase accelerates plasma membrane partitioning in mycobacteria

    Takehiro Kado, Zarina Akbary ... M Sloan Siegrist
    A newly established reversible model of membrane departitioning and repartitioning in bacteria uncovers the role of a cell wall synthase in regulating membrane partitioning.
    1. Ecology
    2. Epidemiology and Global Health

    Mosquito community composition shapes virus prevalence patterns along anthropogenic disturbance gradients

    Kyra Hermanns, Marco Marklewitz ... Sandra Junglen
    Analysis of naturally infected mosquitoes shows that ecosystem disturbance can lead to a turnover in host community composition and that more individuals of a single species are a key driver of virus emergence.
    1. Cell Biology
    2. Computational and Systems Biology

    Continuous sensing of nutrients and growth factors by the mTORC1-TFEB axis

    Breanne Sparta, Nont Kosaisawe ... John G Albeck
    Single-cell data on cell signaling responses to nutrient variation enable quantitative models of cellular control over protein synthesis, formalizing the concept of mTOR as a homeostatic controller of cellular metabolism.
    1. Neuroscience

    Balancing true and false detection of intermittent sensory targets by adjusting the inputs to the evidence accumulation process

    Anna C Geuzebroek, Hannah Craddock ... Simon P Kelly
    In order to adjust for expected difficulty level while detecting unpredictably timed target within continuous streams of noisy information, people regulate the transfer of the sensory inputs to the accumulation process.
    1. Developmental Biology

    Truncated radial glia as a common precursor in the late corticogenesis of gyrencephalic mammals

    Merve Bilgic, Quan Wu ... Fumio Matsuzaki
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    σ28-dependent small RNA regulation of flagella biosynthesis

    Sahar Melamed, Aixia Zhang ... Gisela Storz
    1. Neuroscience

    Glutamatergic Supramammillary Nucleus Neurons Respond to Threatening Stressors and Promote Active Coping

    Abraham Escobedo, Salli-Ann Holloway ... Aaron J. Norris