Latest research

1. 1. Medicine

   Asprosin-neutralizing antibodies as a treatment for metabolic syndrome

   Ila Mishra et al.

   Anti-asprosin monoclonal antibodies, a promising pharmacotherapy for the treatment of metabolic syndrome-associated hyperglycemia, obesity, and dyslipidemia.
2. 1. Neuroscience

   Dorsal Periaqueductal gray ensembles represent approach and avoidance states

   Fernando MCV Reis et al.
3. 1. Microbiology and Infectious Disease

   4-hydroxy-2-nonenal antimicrobial toxicity is neutralized by an intracellular pathogen

   Hannah Tabakh et al.
4. 1. Neuroscience

   Instantaneous movement-unrelated midbrain activity modifies ongoing eye movements

   Antimo Buonocore et al.
5. 1. Cancer Biology
   2. Genetics and Genomics

   Endogenous p53 expression in human and mouse is not regulated by its 3′UTR

   Sibylle Mitschka, Christine Mayr
6. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Non-canonical Hedgehog signaling regulates spinal cord and muscle regeneration in Xenopus laevis larvae

   Andrew M Hamilton et al.
7. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses

   Stephan Wilmes et al.

   IL-27 exerts differential activation of STAT1 and STAT3 via IL-27Ra and GP130, respectively, leading to a kinetic decoupling of its gene expression program, which contributes to tune its immuno-modulatory activities.
8. 1. Developmental Biology
   2. Neuroscience

   Vascular-derived SPARC and SerpinE1 regulate interneuron tangential migration and accelerate functional maturation of human stem cell-derived interneurons

   Matthieu Genestine et al.

   Species-specific timing of interneuron migration across mice and humans is regulated by two vascular-derived factors, SPARC and SerpinE1.
9. 1. Neuroscience
   2. Structural Biology and Molecular Biophysics

   Structural determinants of voltage-gating properties in calcium channels

   Monica L Fernández-Quintero et al.

   Structure modeling, site-directed mutagenesis, and current recordings revealed the mechanism by which stabilization of voltage sensors in the resting and activated states determines the gating properties of the Ca_V1.1 calcium channel.
10. 1. Computational and Systems Biology

    A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice

    Michael A Petr et al.

    A comprehensive cross-sectional assessment reveals functional decline in mice consistent with increased energetic cost of physical activity with age through metabolic rewiring in multiple organs.