Latest research

1. 1. Computational and Systems Biology
   2. Stem Cells and Regenerative Medicine

   The biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle function

   Zachary Clemens et al.

   Transcriptomic analysis using a novel information-based network entropy approach provides mechanistic insights into the ability of Klotho to successfully ameliorate age-related sarcopenia in old mice, but not oldest-old mice.
2. 1. Developmental Biology
   2. Evolutionary Biology

   Selection for increased tibia length in mice alters skull shape through parallel changes in developmental mechanisms

   Colton M Unger et al.

   Artificial selection for increased tibia length in mice made their skulls longer, narrower, and flatter, suggesting that even distant skeletal regions can evolve as correlated responses to selection acting locally.
3. 1. Cell Biology

   UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling

   Stéphanie Torrino et al.

   UBTD1 coordinates EGFR signaling by modulating ceramides level through ASAH1 ubiquitination and EGFR degradation through SQSTM1/p62 ubiquitination, which together impact cell proliferation.
4. 1. Medicine

   Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2

   Salwa Naushin et al.

   Widespread asymptomatic SARS-CoV2 infection affected nearly 100 million Indians by September 2020 with a subsequent decline in new cases, which may be attributable to increased population immunity, albeit seeing reduced neutralization activity at 6 months this respite may be temporary.
5. 1. Genetics and Genomics
   2. Neuroscience

   Propensity for somatic expansion increases over the course of life in Huntington disease

   Radhia Kacher et al.

   Somatic instability of the CAG repeat increases progressively with age and disease progression in Huntington disease mutation carriers, starting with low levels in fetal brain tissues.
6. 1. Neuroscience

   Permeabilization-free en bloc immunohistochemistry for correlative microscopy

   Kara A Fulton, Kevin L Briggman

   Immunohistochemical labeling of antigens deep within mouse brain tissue sections was achieved without the need for lipid permeabilization, thereby preserving tissue ultrastructure and enabling correlative light and electron microscopy studies.
7. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Single-PanIN-seq unveils that ARID1A deficiency promotes pancreatic tumorigenesis by attenuating KRAS-induced senescence

   Shou Liu et al.
8. 1. Cell Biology

   Rapid adaptation of endocytosis, exocytosis and eisosomes after an acute increase in membrane tension in yeast cells

   Joël Lemière et al.
9. 1. Ecology

   The effect of host community functional traits on plant disease risk varies along an elevational gradient

   Fletcher W Halliday et al.
10. 1. Neuroscience

    Bundle-specific associations between white matter microstructure and Aβ and tau pathology in preclinical Alzheimer's disease

    Alexa Pichet Binette et al.