Latest research

1. 1. Structural Biology and Molecular Biophysics

   Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures

   Jan Rheinberger et al.

   High resolution SthK channel cryo-EM structures in different ligand-bound states combined with single-channel functional data in the same conditions constrain a gating mechanism for CNG channels.
2. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   The Peptidisc, a simple method for stabilizing membrane proteins in detergent-free solution

   Michael Luke Carlson et al.

   A simple, yet elegant method for robust self-assembly of diverse membrane proteins into soluble peptide nanoparticles for their structural and functional analysis in detergent-free solutions.
3. 1. Cell Biology
   2. Developmental Biology

   Optogenetic dissection of mitotic spindle positioning in vivo

   Lars-Eric Fielmich et al.
4. 1. Neuroscience

   Constraints on neural redundancy

   Jay A Hennig et al.
5. 1. Neuroscience

   Acute control of the sleep switch in Drosophila reveals a role for gap junctions in regulating behavioral responsiveness

   Michael Troup et al.
6. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   Structural basis for Scc3-dependent cohesin recruitment to chromatin

   Yan Li et al.
7. 1. Evolutionary Biology

   A multispecies coalescent model for quantitative traits

   Fábio K Mendes et al.

   A model for evolutionary inferences at both micro- and macroevolutionary scales is proposed and evaluated theoretically and through simulations.
8. 1. Neuroscience
   2. Structural Biology and Molecular Biophysics

   Cryo-EM structure of alpha-synuclein fibrils

   Ricardo Guerrero-Ferreira et al.

   The alpha-synuclein fibril structure reported here buries residues 50-57 at the interface between its two protofilaments, suggesting that familial Parkinson's disease associated mutations in these residues lead to a structure not compatible with the one presented here.
9. 1. Microbiology and Infectious Disease
   2. Structural Biology and Molecular Biophysics

   Efficient support of virus-like particle assembly by the HIV-1 packaging signal

   Mauricio Comas-Garcia et al.

   The packaging signal in HIV-1 genomic RNA supports in vitro particle assembly more efficiently than control RNAs, probably explaining its selective packaging during virus assembly in vivo.
10. 1. Neuroscience

    Effects of spinal cord stimulation on postural control in Parkinson's disease patients with freezing of gait

    Andrea Cristina de Lima-Pardini et al.

    High-frequency stimulation of the upper thoracic spinal cord corrects anticipatory postural adjustments and improving gait efficiency and inhibiting freezing of gait episodes in advanced Parkinson's disease.