Highlights

We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Synaptic Organization of Surface AMPARs Changes by Brain Region and Tauopathy

    Rohit M Vaidya, Jiahao Zhang ... Paul R Selvin
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Genetics and Genomics
    2. Immunology and Inflammation

    GM-CSF regulates conserved ILC-like transcriptional states and myeloid cell signaling during ulceration in Crohn’s disease

    Joshua K Morrison, Ksenija Sabic ... Ling-shiang Chuang
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Developmental Biology

    Cataloguing the mouse small intestinal transcriptome in duodenum and ileum during the first postnatal month

    Luiz Fernando Silva Oliveira, Radhika S Khetani ... Amy E O’Connell
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Ecology

    Novel but stable endosymbionts have contrasting effects on aphid dispersal and plant feeding damage in the cereal pest Diuraphis noxia

    Xinyue Gu, Alex Gill ... Ary Hoffmann
    Naturally occurring bacterial endosymbionts can modify population growth, crop damage, and dispersal in the Russian wheat aphid, a major pest of cereal crops, highlighting their potential for sustainable pest management.
    1. Neuroscience

    Complementary stable and dynamic prelimbic ensembles encode learned threat value underlying generalization and discrimination

    Marc E Normandin, Pedro M Ogallar ... Isabel A Muzzio
    Stable and dynamic prelimbic neurons preserve threat-generalization gradients despite ensemble turnover, supporting enduring representations of stimulus significance rather than freezing.
    1. Neuroscience

    A mechanistic theory of planning in prefrontal cortex

    Kristopher T Jensen, Peter T Doohan ... Timothy E Behrens
    Recently discovered sequence representations in prefrontal cortex can be combined with the ubiquitous principle of neural attractor dynamics to support planning in complex environments.
    1. Neuroscience

    Strong mnemonic prediction errors increase cognitive control, attention, and arousal

    Alice M Xue, Jenna Jokhani ... Anthony D Wagner
    Violations of strong memory-based predictions trigger a cascade of changes in cognitive control, attention, and arousal, with differential impacts on the encoding of unexpected information into memory.
    1. Cell Biology

    p66Shc mediates SUMO2-induced endothelial dysfunction

    Jitendra Kumar, Shravan K Uppulapu ... Santosh Kumar
    SUMO2ylation of redox protein p66Shc drives endothelial dysfunction by promoting oxidative stress, identifying a potential therapeutic target for cardiovascular disease.
    1. Immunology and Inflammation

    Role of gut epithelial-cell derived transglutaminase 2 in the formation of celiac disease autoantibodies

    Runa I Løberg, Helena A Abdi-Dezfuli ... M Fleur du Pré
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    An integrated human forebrain organoid reveals microglia-mediated CD8+ T cell recruitment and neuroimmune dysfunction in Alzheimer’s disease pathology

    Yilin Feng, Feifei Yu ... Shaohua Ma
    Human forebrain organoids reveal that amyloid-driven microglia recruit killer T cells via CCL5, forming a self-amplifying neuroinflammatory loop targetable by CCR5 or CXCR3 blockade.
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Magazine

    1. Microbiology and Infectious Disease

    Bird Flu: The cow udder as an influenza mixing ground

    Silke Rimaux, Robert P de Vries
    1. Computational and Systems Biology

    AI in Science: The 42 problem in AI-assisted research

    Giovanni Spitale, Federico Germani
    1. Genetics and Genomics
    2. Developmental Biology
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    Lifestyle, Environment and Epigenetic Inheritance: A Collection of Articles

    Edited by Wei Yan

  4. Research Culture: From East to West – an early-career researcher’s voyage across continents

    Samuel C Eziuzor
  5. Close-up of an iris

    Episode 105: September 2026

    1. Cell Biology
    2. Computational and Systems Biology

    Philosophy of Biology: The power of theory in the life sciences

    Jacob L Fine, Finn Creeggan ... Adam MR Groh
    1. Genetics and Genomics

    Environmental Learning: How experience shapes individuality

    Bassem A Hassan
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
  16. Physiology
  17. Plant Biology
  18. Stem Cells and Regenerative Medicine
  19. Structural Biology and Molecular Biophysics
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