Highlights

  • T-cells target TB-infected cells

    Complementary human in vitro systems suggest a non-classical T-cell pathway contributing to immunity against Mycobacterium tuberculosis infection

    Matthew Milton, Sahar H Farag ... Salah Mansour
    Reviewed Preprint Updated

  • Mapping Regulatory DNA

    Cis-regulatory elements in the large genome of Parhyale hawaiensis can be identified by integrating chromatin accessibility and sequence conservation data.

    Gillian Forbes, Emilia Skafida ... Mathilde Paris
    Reviewed Preprint Updated

  • Hypoxia to healthspan

    Genetic tools highlight potential signalling components underlying hypoxia-induced longevity in C. elegans.

    Elizabeth S Kitto, Shijiao Huang ... Scott F Leiser
    Reviewed Preprint Updated

  • Publish-review-curate at eLife

    eLife is rethinking how research is reviewed and published.

    Timothy E Behrens, Yamini Dalal, Diane M Harper
    Editorial

  • AI in research communication

    eLife has partnered on a number of projects harnessing AI for improving human and machine reader engagement with research.

    Inside eLife

  • Science under threat

    How should the scientific community respond to ideological attacks on science?

    Humberto J Debat
    Feature Article
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Cancer Biology

    Microbial Metabolites Potentiate MAIT Cell Anti-Tumor Immunity Against Solid Tumors

    Yichen Zhu, Xinyuan Shen ... Lili Yang
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cell Biology

    A Quartet of Native Orai Channel Isoforms Orchestrates Graded NFAT Activation and Transcription

    Ahmed Emam Abdelnaby, Yin-Hu Wang ... Mohamed Trebak
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Covert attention dynamically shapes decision making

    Amy X Li, Benjamin Chan ... Laurence T Hunt
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Focused ultrasound alters neural time irreversibility independently of response amplitude

    Jacek P Dmochowski, David H Wolpert
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Physics of Living Systems

    Anatomy and mechanics of tsetse fly blood feeding

    Stephan Löwe, Laura Hauf ... Markus Engstler
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Cell Biology
    2. Cancer Biology

    Molecular and Functional Analysis of Calcium Binding by a Cancer-linked Calreticulin Mutant

    Ishmael Nii Ayibontey Tagoe, Amanpreet Kaur ... Malini Raghavan
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Physics of Living Systems

    A unifying model of T-cell signaling protein condensates in reconstitution experiments

    Yannick Azhri Din Omar, Simou Sun ... Arup K Chakraborty
    The formation of biomolecular condensates by multivalent membrane proteins is delayed by slow crosslinking dynamics, with a variety of condensate morphologies emerging under different experimental conditions.
    1. Cell Biology

    Wound-induced syncytia outpace mononucleate neighbors during Drosophila wound repair

    James S White, Junmin Hua ... Andrea Page-McCaw
    In vivo live imaging, quantitative analysis, and computational modeling reveal that wound-induced epithelial cell fusion accelerates epithelial repair through several likely mechanisms.
    1. Neuroscience

    Retinotopic coding organizes the interaction between internally and externally oriented brain networks

    Adam Steel, Peter A Angeli, Caroline Robertson
    Internally and externally oriented brain networks are functionally coupled at a voxel scale through a common visuospatial code.
    1. Neuroscience

    Pathogenic O-GlcNAc dyshomeostasis is associated with cortical malformations and hyperactivity

    Florence Authier, Asad Jan ... Daan MF van Aalten
    A mouse model of O-GlcNAc transferase associated intellectual disability reveals brain structural and cognitive deficits providing an important platform for mechanistic and therapeutic discovery.
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Magazine

    1. Cell Biology
    2. Computational and Systems Biology

    Philosophy of Biology: The power of theory in the life sciences

    Jacob L Fine, Finn Creeggan ... Adam MR Groh
    1. Genetics and Genomics

    Environmental Learning: How experience shapes individuality

    Bassem A Hassan

  3. Point of View: Scientific writing is not a murder mystery

    Charlotte A Dodson
    1. Neuroscience

    Visual Categorization: How monkeys carve up the visual world

    Binxu Wang
    1. Cell Biology

    Stress: How to give cells an identity crisis

    Paige Dillon, Julie Hollien
    1. Epidemiology and Global Health

    Malaria Prevention: Using mathematical models to optimise mosquito net distribution

    Carlos A Prete Jr
    1. Plant Biology

    Mixotrophy: An updated view of glucose pathways in cyanobacteria

    José Manuel García-Fernández
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