Latest research

1. 1. Human Biology and Medicine
   2. Immunology and Inflammation

   Response to comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'

   Christina Hertel et al.

   We are writing to reply to the comment by Landegren et al., 2019 about our study (Meyer et al., 2016) on disease-ameliorating autoantibodies.
2. 1. Human Biology and Medicine
   2. Immunology and Inflammation

   Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'

   Nils Landegren et al.

   We are writing to comment on the study by Meyer et al., 2016 on disease-ameliorating autoantibodies.
3. 1. Chromosomes and Gene Expression
   2. Plant Biology

   Natural depletion of histone H1 in sex cells causes DNA demethylation, heterochromatin decondensation and transposon activation

   Shengbo He et al.

   Transposon activation during male gametogenesis is caused by interactions between DNA demethylation and linker histone H1, developmental depletion of which promotes pollen fertility.
4. 1. Biochemistry and Chemical Biology

   The mechanism of error induction by the antibiotic viomycin provides insight into the fidelity mechanism of translation

   Mikael Holm et al.

   The antibiotic viomycin induces errors during initial codon selection by the ribosome by locking the monitoring bases in their active conformation.
5. 1. Neuroscience
   2. Stem Cells and Regenerative Medicine

   Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons

   Disi An et al.

   Stem cell-derived motor neurons with differential ALS vulnerability identified proteasome activity as a possible mechanism that explains their differential sensitivity.
6. 1. Biochemistry and Chemical Biology
   2. Human Biology and Medicine

   GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients

   Xuchen Hu et al.

   The expression of the lipoprotein lipase (LPL) transporter GPIHBP1 in glioma capillaries promotes the LPL-mediated processing of triglyceride-rich lipoproteins, thereby providing lipid nutrients for glioma cells.
7. 1. Cell Biology
   2. Neuroscience

   Pregnancy-associated plasma protein-aa supports hair cell survival by regulating mitochondrial function

   Mroj Alassaf et al.

   Hair cell survival and mitochondrial function is supported by an extracellular stimulator of IGF1 signaling, the protease pregnancy-associated plasma protein-aa.
8. 1. Structural Biology and Molecular Biophysics

   Cystic fibrosis drug ivacaftor stimulates CFTR channels at picomolar concentrations

   László Csanády, Beáta Töröcsik

   Aqueous solubility of cystic fibrosis drug ivacaftor is ~200-fold lower, whereas the potency of its stimulatory effect on the CFTR channel is >100-fold higher, than reported, and is fully reversible.
9. 1. Cell Biology
   2. Physics of Living Systems

   Metabolic constraints drive self-organization of specialized cell groups

   Sriram Varahan et al.
10. 1. Neuroscience

    Imaging neuropeptide release at synapses with a genetically engineered reporter

    Keke Ding et al.