Latest research

1. 1. Structural Biology and Molecular Biophysics

   Cryo-EM structure of the mechanically activated ion channel OSCA1.2

   Sebastian Jojoa-Cruz et al.

   Structures of OSCA1.2, a member of a newly characterized family of mechanically activated ion channels, provide insights into mechanism of channel gating by membrane tension.
2. 1. Evolutionary Biology
   2. Structural Biology and Molecular Biophysics

   OSCA/TMEM63 are an Evolutionarily Conserved Family of Mechanically Activated Ion Channels

   Swetha E Murthy et al.

   Characterization of a family of proteins (OSCA/TMEM63) that encode mechanosensitive ion channels in plants, flies, and mammals.
3. 1. Computational and Systems Biology
   2. Neuroscience

   Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model

   Daniel B Dorman et al.

   Inhibition enhances the spatial specificity of high calcium influx for cooperatively stimulated synapses, suggesting that inhibitory inputs may regulate both synapse-specific and heterosynaptic plasticity to support learning and memory.
4. 1. Microbiology and Infectious Disease

   Genetic basis for coordination of meiosis and sexual structure maturation in Cryptococcus neoformans

   Linxia Liu et al.

   Meiosis and differentiation of basidium, a defining sexual structure of the phylum Basidiomycota, are genetically integrated by a shared regulatory program to ensure the formation of infectious meiospores in Cryptococcus neoformans.
5. 1. Biochemistry and Chemical Biology
   2. Plant Biology

   Effects of microcompartmentation on flux distribution and metabolic pools in Chlamydomonas reinhardtii chloroplasts

   Anika Küken et al.

   Mathematical models reveal that under the physiologically different conditions ambient and high CO2, two algal microcompartments are metabolically connected by facilitated transport.
6. 1. Evolutionary Biology
   2. Neuroscience

   Recalibrating timing behavior via expected covariance between temporal cues

   Benjamin J De Corte et al.

   Rats act as if they expect that the delays associated with temporal cues will covary due to a common causal factor.
7. 1. Microbiology and Infectious Disease

   High resolution mapping of fluoroquinolones in TB rabbit lesions reveals specific distribution in immune cell types

   Landry Blanc et al.
8. 1. Stem Cells and Regenerative Medicine

   Long-term live imaging of the Drosophila adult midgut reveals real-time dynamics of division, differentiation, and loss

   Judy Lisette Martin et al.
9. 1. Cell Biology
   2. Developmental Biology

   Shear-induced damped oscillations in an epithelium depend on actomyosin contraction and E-cadherin cell adhesion

   Ehsan Sadeghipour et al.

   Cell movement toward and away from the midline of an epithelium over tens of hours are caused by spontaneous or externally-applied shear forces to eliminate force imbalances within the tissue.
10. 1. Chromosomes and Gene Expression

    A whole lifespan mouse multi-tissue DNA methylation clock

    Margarita V Meer et al.