ERK3 in control

Latest research

1. 1. Developmental Biology

   Npr3 regulates neural crest and cranial placode progenitors formation through its dual function as clearance and signaling receptor

   Arun Devotta, Hugo Juraver-Geslin ... Jean-Pierre Saint-Jeannet

   A combination of morpholino-based knockdowns, pharmacological inhibitors, and rescue assays reveal a novel role for natriuretic peptide signaling in the regulation of cell fates in the embryonic ectoderm.
2. 1. Cell Biology
   2. Microbiology and Infectious Disease

   Profiling the bloodstream form and procyclic form Trypanosoma brucei cell cycle using single-cell transcriptomics

   Emma M Briggs, Catarina A Marques ... Keith R Matthews

   Single-cell transcriptomics of cryopreserved parasites reveals extensive cyclic regulation of mRNA abundance by Trypanosoma brucei during the cell cycle.
3. 1. Cancer Biology
   2. Computational and Systems Biology

   Predictive nonlinear modeling of malignant myelopoiesis and tyrosine kinase inhibitor therapy

   Jonathan Rodriguez, Abdon Iniguez ... Richard A Van Etten

   A physiological mathematical model of chronic myeloid leukemia, validated by experiments in transgenic mice and clinical data, identifies mechanisms underlying the response to tyrosine kinase inhibitor therapy, predicts biomarkers of primary resistance, and suggests new strategies to improve treatment outcomes.
4. 1. Computational and Systems Biology

   Sex, strain, and lateral differences in brain cytoarchitecture across a large mouse population

   David Elkind, Hannah Hochgerner ... Amit Zeisel

   Across individuals of a mouse population, brain regions volumes scaled to accommodate the same amount of cells, but left hemisphere cortical regions were denser than right, and several regions of the limbic system were more pronounced in either sex.
5. 1. Medicine
   2. Neuroscience

   Tiered sympathetic control of cardiac function revealed by viral tracing and single cell transcriptome profiling

   Sachin Sharma, Russell Littman ... Olujimi A Ajijola

   Cardiac-specific neurons residing in stellate ganglia comprised of three subsets of neurons based upon their transcriptomic and neurochemical properties and modulates cardiac sympathetic control.
6. 1. Neuroscience

   Ultrafast (400 Hz) network oscillations induced in mouse barrel cortex by optogenetic activation of thalamocortical axons

   Hang Hu, Rachel E Hostetler, Ariel Agmon

   Brief optogenetic stimulation of thalamocortical axons evoked a 400 Hz wavelet, 'ripplet,' in the extracellular field potential in cortical layer 4, together with phase-locked spike bursts in fast-spiking inhibitory interneurons and alternating excitatory and inhibitory synaptic currents in excitatory cells.
7. 1. Stem Cells and Regenerative Medicine

   Inhibition of Type I PRMTs Reforms Muscle Stem Cell Identity Enhancing their Therapeutic Capacity

   Claudia Dominici, Oscar D. Villarreal ... Stéphane Richard
8. 1. Stem Cells and Regenerative Medicine

   IL-6 signaling exacerbates hallmarks of chronic tendon disease by stimulating progenitor proliferation & migration to damage

   Tino Stauber, Greta Moschini ... Jess G. Snedeker
9. 1. Neuroscience

   Chemo- and optogenetic activation of hypothalamic Foxb1-expressing neurons and their terminal endings in the rostral-dorsolateral PAG leads to tachypnea, bradycardia, and immobility

   Reto B. Cola, Diana M. Roccaro-Waldmeyer ... Marco R. Celio
10. 1. Neuroscience

    Task-evoked metabolic demands of the posteromedial default mode network are shaped by dorsal attention and frontoparietal control networks

    Godber M Godbersen, Sebastian Klug ... Andreas Hahn