Latest research

1. 1. Chromosomes and Gene Expression

   Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease

   Gang Wu et al.

   RNA profiles from lungs of mice exposed to intermittent hypoxia shared similarity with gene expression changes in human lung from patients with pulmonary diseases, including pulmonary hypertension, COPD, and asthma.
2. 1. Cell Biology
   2. Structural Biology and Molecular Biophysics

   Structural basis of Stu2 recruitment to yeast kinetochores

   Jacob A Zahm et al.

   The results here show that Stu2 binds kinetochores by associating with the Ndc80 complex and that the interaction is critical for accurate chromosome segregation during cell division.
3. 1. Neuroscience

   The connectome of the adult Drosophila mushroom body provides insights into function

   Feng Li et al.

   Analysis of neuronal circuit architecture provides mechanistic insights into what an adult fly can learn, remember, and use to guide its behavior.
4. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics

   Haibin Yang et al.

   Structural, biochemical, and cell biology study revealed that Rsu1, through binding to PINCH1, inhibits the actin bundling ability of ILK/PINCH/Parvin to regulate the actin dynamics at focal adhesion.
5. 1. Neuroscience

   Dissociation of task engagement and arousal effects in auditory cortex and midbrain

   Daniela Saderi et al.

   Data collected from two important auditory brain areas distinguish effects of generalized arousal and specific task engagement on neural sensory coding.
6. 1. Biochemistry and Chemical Biology

   Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

   Rajendra Uprety et al.

   The structure-based design established a new approach to control pathway-selective activation of opioid receptors, resulting in new dual MOR/KOR G-protein biased agonist analgesics with attenuated liabilities.
7. 1. Computational and Systems Biology
   2. Ecology

   TRex, a fast multi-animal tracking system with markerless identification, and 2D estimation of posture and visual fields

   Tristan Walter, Iain D Couzin
8. 1. Evolutionary Biology
   2. Microbiology and Infectious Disease

   Integron activity accelerates the evolution of antibiotic resistance

   Célia Souque et al.
9. 1. Physics of Living Systems
   2. Stem Cells and Regenerative Medicine

   DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome

   Simona Hankeova et al.

   Dual resin casting of multiple lumenized systems followed by microCT allows visualization, digitalization, and quantification of architectural parameters defining the vascular and biliary systems in liver revealing new phenotypes.
10. 1. Neuroscience

    Brain endothelial cell TRPA1 channels initiate neurovascular coupling

    Pratish Thakore et al.