Latest research

1. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Quantitative prediction of variant effects on alternative splicing in MAPT using endogenous pre-messenger RNA structure probing

   Jayashree Kumar et al.

   A novel model is presented that reconciles in-cell structure probing data with splicing regulatory elements to predict exon 10 inclusion of the Tau gene with high accuracy for 53 splice altering mutations.
2. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Cytotoxic CD4⁺ T cells driven by T-cell intrinsic IL-18R/MyD88 signaling predominantly infiltrate Trypanosoma cruzi-infected hearts

   Carlos-Henrique D Barbosa et al.

   Cytotoxic CD4 T lymphocytes are abundantly generated in T. cruzi-infected mice, predominantly infiltrate infected hearts, depend on T-cell intrinsic IL-18R/MyD88 signaling for expansion and their blood frequency correlates with the severity of chronic myocarditis in patients with Chagas disease.
3. 1. Cell Biology
   2. Developmental Biology

   TUBA1A tubulinopathy mutants disrupt neuron morphogenesis and override XMAP215/Stu2 regulation of microtubule dynamics

   Katelyn J Hoff et al.

   The mechanistic origins of distinct brain malformations associated with different substitutions at α-tubulin residue 409 are examined, revealing disruption of neuronal migration and microtubule regulation by XMAP215 that scales from protein to tissue.
4. 1. Cell Biology

   Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion

   Yang Zhang et al.

   A previously unknown calcium channel in human placental trophoblasts provides a calcium source for activating TMEM16F lipid scramblase that flip-flops phospholipids on cell surface, demonstrating a physiological mechanism that helps to understand how lipid dynamics regulates cell fusion.
5. 1. Cancer Biology
   2. Cell Biology

   Global cellular response to chemical perturbation of PLK4 activity and abnormal centrosome number

   Johnny M Tkach et al.

   Genome-wide CRISPR screens in human cells identifies a role for TRIM37 in growth arrest after chemical inhibition of PLK4.
6. 1. Neuroscience

   Integration of visual and antennal mechanosensory feedback during head stabilization in hawkmoths

   Payel Chatterjee et al.
7. 1. Cancer Biology
   2. Cell Biology

   Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation

   Haoran Zhu et al.

   Cystathionine-β-synthase is a novel metabolic regulator of AKT-induced senescence and a potential tumor suppressor in gastric cancer pathogenesis which can be harnessed to target PI3K/AKT-driven cancers.
8. 1. Stem Cells and Regenerative Medicine

   Cardiac differentiation of human pluripotent stem cells using defined extracellular matrix proteins reveals essential role of fibronectin

   Jianhua Zhang et al.

   Investigation of defined extracellular matrix proteins in differentiation of human pluripotent stem cells to cardiomyocytes reveals fibronectin, in addition to soluble factors, is required for cardiogenesis.
9. 1. Cell Biology

   Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton

   Bhaba K Das et al.
10. 1. Cancer Biology
    2. Cell Biology

    The integrated stress response remodels the microtubule organizing center to clear unfolded proteins following proteotoxic stress

    Brian Hurwitz et al.