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A novel optical microscope for imaging large embryos and tissue volumes with sub-cellular resolution throughout

A new type of microscope reveals detail of organelles inside every cell in the entirety of an intact embryo or tissue region over 100 cubic millimeters in volume.
  • Gail McConnell
  • Johanna Trägårdh
  • Rumelo Amor
  • John Dempster
  • Es Reid
  • William Bradshaw Amos
10.7554/eLife.18659
Research Article Neuroscience Developmental Biology and Stem Cells
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Seipin is required for converting nascent to mature lipid droplets

Seipin oligomers dynamically interact with small, nascent lipid droplets near the endoplasmic reticulum to convert them into larger, mature lipid droplets in a newly identified step of lipid droplet formation.
  • Huajin Wang
  • Michel Becuwe
  • Benjamin E Housden
  • Chandramohan Chitraju
  • Ashley J Porras
  • Morven M Graham
  • Xinran N Liu
  • Abdou Rachid Thiam
  • David B Savage
  • Anil K Agarwal
  • Abhimanyu Garg
  • Maria-Jesus Olarte
  • Qingqing Lin
  • Florian Fröhlich
  • Hans Kristian Hannibal-Bach
  • Srigokul Upadhyayula
  • Norbert Perrimon
  • Tomas Kirchhausen
  • Christer S Ejsing
  • Tobias C Walther
  • Robert V Farese Jr
10.7554/eLife.16582
Research Article Cell Biology
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Odd-paired controls frequency doubling in Drosophila segmentation by altering the pair-rule gene regulatory network

The organisation of the Drosophila embryo into segmental units is orchestrated by combinatorial regulatory interactions between spatially patterned and temporally patterned transcription factors.
  • Erik Clark
  • Michael Akam
10.7554/eLife.18215
Research Article Computational and Systems Biology Developmental Biology and Stem Cells
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Dissecting the pre-placodal transcriptome to reveal presumptive direct targets of Six1 and Eya1 in cranial placodes

RNA sequencing of the African clawed frog has identified hundreds of putative direct Six1 and Eya1 target genes, including transcriptional regulators of neuronal progenitors and neuronal/sensory differentiation.
  • Nick Riddiford
  • Gerhard Schlosser
10.7554/eLife.17666
Research Article Developmental Biology and Stem Cells
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Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis

PASK phosphorylates Wdr5 to trigger epigenetic changes at lineage specifying promoters resulting in transcriptional derepression and differentiation of stem or progenitor cells.
  • Chintan K Kikani
  • Xiaoying Wu
  • Litty Paul
  • Hana Sabic
  • Zuolian Shen
  • Arvind Shakya
  • Alexandra Keefe
  • Claudio Villanueva
  • Gabrielle Kardon
  • Barbara Graves
  • Dean Tantin
  • Jared Rutter
10.7554/eLife.17985
Research Article Biochemistry Developmental Biology and Stem Cells
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A robust activity marking system for exploring active neuronal ensembles

A new system for tagging activated neuronal population offers multiple advantages over existing systems based on immediate early genes, including greater sensitivity and specificity, and suitability for easy application in species other than mice.
  • Andreas T Sørensen
  • Yonatan A Cooper
  • Michael V Baratta
  • Feng-Ju Weng
  • Yuxiang Zhang
  • Kartik Ramamoorthi
  • Robin Fropf
  • Emily LaVerriere
  • Jian Xue
  • Andrew Young
  • Colleen Schneider
  • Casper René Gøtzsche
  • Martin Hemberg
  • Jerry CP Yin
  • Steven F Maier
  • Yingxi Lin
10.7554/eLife.13918
Tools and Resources Neuroscience
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A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading

A lysine-to-methionine mutation in histone H3 dominantly blocks histone H3K9 methylation by trapping its methyltransferase.
  • Chun-Min Shan
  • Jiyong Wang
  • Ke Xu
  • Huijie Chen
  • Jia-Xing Yue
  • Stuart Andrews
  • James J Moresco
  • John R Yates III
  • Peter L Nagy
  • Liang Tong
  • Songtao Jia
10.7554/eLife.17903
Research Article Genes and Chromosomes
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Targeting senescent cells enhances adipogenesis and metabolic function in old age

Senescent cells contribute to age-related fat dysfunction and can directly impair healthy fat progenitor function, in part, via the secretion of activin A.
  • Ming Xu
  • Allyson K Palmer
  • Husheng Ding
  • Megan M Weivoda
  • Tamar Pirtskhalava
  • Thomas A White
  • Anna Sepe
  • Kurt O Johnson
  • Michael B Stout
  • Nino Giorgadze
  • Michael D Jensen
  • Nathan K LeBrasseur
  • Tamar Tchkonia
  • James L Kirkland
10.7554/eLife.12997
Research Article Developmental Biology and Stem Cells Human Biology and Medicine
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CD301b+ dendritic cells suppress T follicular helper cells and antibody responses to protein antigens

CD301b dendritic cells potently suppress antibody responses by limiting the activity of follicular helper T cells and germinal center B cells.
  • Yosuke Kumamoto
  • Toshiro Hirai
  • Patrick W Wong
  • Daniel H Kaplan
  • Akiko Iwasaki
10.7554/eLife.17979
Research Article Immunology
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Loss of ZBTB20 impairs circadian output and leads to unimodal behavioral rhythms

The zinc finger protein ZBTB20 is a morning and evening activity gating factor in mice.
  • Zhipeng Qu
  • Hai Zhang
  • Moli Huang
  • Guangsen Shi
  • Zhiwei Liu
  • Pancheng Xie
  • Hui Li
  • Wei Wang
  • Guoqiang Xu
  • Yang Zhang
  • Ling Yang
  • Guocun Huang
  • Joseph S Takahashi
  • Weiping J Zhang
  • Ying Xu
10.7554/eLife.17171
Research Article Neuroscience
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