Latest research

1. 1. Cell Biology
   2. Neuroscience

   TMC1 is an essential component of a leak channel that modulates tonotopy and excitability of auditory hair cells in mice

   Shuang Liu et al.

   Other than its function in mechanotransduction, TMC1 is indispensable for action potential firing of auditory hair cells by mediating a leak conductance that alters tonotopically along the cochlea coil.
2. 1. Cell Biology

   The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity

   Tsui Han Loo et al.

   The LINC complex, that couples the interphase cytoskeleton to the nucleus, regulates the processing of a cluster of miRNAs required for muscle regeneration by recruiting and interacting directly with Drosha.
3. 1. Immunology and Inflammation

   Atypical memory B-cells are associated with Plasmodium falciparum anemia through anti-phosphatidylserine antibodies

   Juan Rivera-Correa et al.

   The association of atypical memory B-cells and autoimmune antibodies (anti-phosphatidylserine) with hemoglobin levels in malaria patients uncovers a novel mechanism for the human malaria-induced anemia previously identified in mice.
4. 1. Structural Biology and Molecular Biophysics

   Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding

   Janelle Lauer et al.
5. 1. Cell Biology
   2. Developmental Biology

   Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex

   Yue Qu et al.
6. 1. Neuroscience

   Reliability of an interneuron response depends on an integrated sensory state

   May Dobosiewicz et al.
7. 1. Human Biology and Medicine

   Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease

   Robert N Helsley et al.

   Loss of function of membrane-bound O-acyltransferase 7 (MBOAT7), but not transmembrane channel-like 4 (TMC4), promotes hepatic steatosis.
8. 1. Neuroscience

   Structured inhibitory activity dynamics in new virtual environments

   Moises Arriaga, Edward B Han

   Inhibitory interneuron activity is dynamically modulated in new environments while individual interneurons show consistent levels of activity modulation across multiple environments, suggesting functional specialization of inhibitory subnetworks.
9. 1. Biochemistry and Chemical Biology

   PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

   Kerryn Berndsen et al.

   PPM1H protein phosphatase dephosphorylates Rab proteins modulating LRRK2 signalling.
10. 1. Neuroscience

    Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms

    Shogo Haraguchi et al.

    Diurnal variation loss of pineal allopregnanolone synthesis by light-at-night induces pituitary adenylate cyclase-activating polypeptide (PACAP) reduction and transcriptional PACAP repression in the cerebellum, with subsequent Purkinje cell death.