Latest research

1. 1. Developmental Biology
   2. Neuroscience

   Sociosexual behavior requires both activating and repressive roles of Tfap2e/AP-2ε in vomeronasal sensory neurons

   Jennifer M Lin, Tyler A Mitchell ... Paolo Emanuele Forni

   In vivo genetic experiments show that aberrant expression of a transcription factor can compromise the functionality of neurons which is important to better understand the potential mechanisms underlying neuropathologies.
2. 1. Neuroscience

   Learning of probabilistic punishment as a model of anxiety produces changes in action but not punisher encoding in the dmPFC and VTA

   David S Jacobs, Madeleine C Allen ... Bita Moghaddam

   A novel approach to studying anxiety reveals that learned anxiety and diazepam treatment have unique roles on prefrontal cortex and ventral tegmental area activity.
3. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   DNA methylome combined with chromosome cluster-oriented analysis provides an early signature for cutaneous melanoma aggressiveness

   Arnaud Carrier, Cécile Desjobert ... Paola B Arimondo

   An original molecular multi-step approach integrating DNA methylome and chromosome-cluster localization cross-analysis identified a DNA methylation signature of patient outcome supporting that the core DNA methylation for a given trait is independent of the physiological context under which it arises.
4. 1. Immunology and Inflammation

   Memory persistence and differentiation into antibody-secreting cells accompanied by positive selection in longitudinal BCR repertoires

   Artem Mikelov, Evgeniia I Alekseeva ... Ivan V Zvyagin

   High degree of clonal persistence and excess of inter-individual convergence are observed in human memory B cell repertoires, along with signatures of both negative and positive selection in most abundant clonal lineages.
5. 1. Computational and Systems Biology
   2. Plant Biology

   Computational modeling and quantitative physiology reveal central parameters for brassinosteroid-regulated early cell physiological processes linked to elongation growth of the Arabidopsis root

   Ruth Großeholz, Friederike Wanke ... Klaus Harter

   The recurring application of computational modelling combined with wet lab experiments identify and predict central regulatory parameters and factors for early cell physiological reactions linked to differential brassinosteroid-modified elongation growth in the root tip of Arabidopsis thaliana.
6. 1. Neuroscience

   Repressor element 1-silencing transcription factor deficiency yields profound hearing loss through K_v7.4 channel upsurge in auditory neurons and hair cells

   Haiwei Zhang, Hongchen Li ... Ping Lv

   In the cochlea, repressor element 1-silencing transcription factor (REST) regulates the expression levels of K_v7.4 and alterations of REST functions result in progressive hearing loss.
7. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Airway basal cells show regionallydistinct potential to undergo metaplastic differentiation

   Yizhuo Zhou, Ying Yang ... Wellington V Cardoso
8. 1. Evolutionary Biology
   2. Genetics and Genomics

   Protein evidence of unannotated ORFs in Drosophila reveals diversity in the evolution and properties of young proteins

   Eric B Zheng, Li Zhao
9. 1. Stem Cells and Regenerative Medicine

   In vivo generation of bone marrow from embryonic stem cells in interspecies chimeras

   Bingqiang Wen, Guolun Wang ... Vladimir V Kalinichenko
10. 1. Biochemistry and Chemical Biology
    2. Cell Biology

    Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform

    Dirk H Siepe, Lukas T Henneberg ... Kenan Christopher Garcia