Latest research

1. 1. Neuroscience

   Molecular pathway analysis towards understanding tissue vulnerability in spinocerebellar ataxia type 1

   Terri M Driessen et al.

   Unbiased transcriptomics reveals novel insights into the mechanisms that may contribute to regional neurodegeneration in SCA1, and other SCAs in general.
2. 1. Cell Biology

   The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage

   Eutteum Jeong et al.

   Disruption of TFEB and TFE3 results in diminished p53 signaling capacity and altered cell cycle regulation under genotoxic stress conditions.
3. 1. Neuroscience

   Sucrose intensity coding and decision-making in rat gustatory cortices

   Esmeralda Fonseca et al.

   The neural representation of perceived sucrose intensity was contained in the firing rate and spike-timing of a 'small' population of neurons distributed across the Insula and Orbitofrontal taste cortices.
4. 1. Cancer Biology

   miR-34a is a microRNA safeguard for Citrobacter-induced inflammatory colon oncogenesis

   Lihua Wang et al.
5. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Meiotic drive of female-inherited supernumerary chromosomes in a pathogenic fungus

   Michael Habig et al.
6. 1. Epidemiology and Global Health
   2. Microbiology and Infectious Disease

   Structured illumination microscopy combined with machine learning for the high throughput analysis of virus structure

   Romain F Laine et al.
7. 1. Evolutionary Biology
   2. Genetics and Genomics

   Gene flow mediates the role of sex chromosome meiotic drive during complex speciation

   Colin D Meiklejohn et al.

   Selfish genetic elements may either promote or prevent the evolution of reproductive barriers, depending on the extent of gene flow between species.
8. 1. Neuroscience

   Reactive oxygen species regulate activity-dependent neuronal plasticity in Drosophila

   Matthew C W Oswald et al.
9. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Role of the pre-initiation complex in Mediator recruitment and dynamics

   Elisabeth R Knoll et al.
10. 1. Cell Biology

    The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1

    Sam A Menzies et al.

    CRISPR/Cas9 genome-wide screens using sterol-sensitive endogenous HMG-CoA reductase (HMGCR) reporter identify the sterol-responsive RNF145 and gp78 as independently responsible for sterol-accelerated degradation of HMGCR, the rate-limiting enzyme of cholesterol biosynthesis.