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Highlights

  • Evolution and ion channels

    Acid-sensing ion channels emerged earlier during the evolution of bilaterians than previously thought. Image: Andreas Hejnol (CC BY 4.0).

    Josep Martí-Solans, Aina Børve ... Timothy Lynagh
    Research Article

  • A new way to publish

    All papers reviewed by eLife are published as Reviewed Preprints, which combine the advantages of preprints with the scrutiny offered by peer review

    Inside eLife

  • A code for RNA localization

    Experiments on RNA point to the existence of an RNA localization ‘code’ that operates in multiple cell types and is conserved across species.

    Raeann Goering, Ankita Arora ... J Matthew Taliaferro
    Research Article

Latest research

    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Mitochondrial redox adaptations enable alternative aspartate synthesis in SDH-deficient cells

    Madeleine L Hart, Evan Quon ... Lucas B Sullivan
    SDH-null cancer cells decrease mitochondrial complex I to drive rewired aspartate synthesis through reductive carboxylation and pyruvate carboxylase, supporting cell proliferation and tumor growth.
    1. Computational and Systems Biology

    Dynamics of co-substrate pools can constrain and regulate metabolic fluxes

    Robert West, Hadrien Delattre ... Orkun S Soyer
    Mathematical analyses explore the impact of co-substrate cycling on the dynamics of cellular metabolism, and demonstrate that these dynamics can limit cellular fluxes and that co-substrate pool dynamics can be regulated to regulate fluxes.
    1. Stem Cells and Regenerative Medicine

    Live imaging reveals chromatin compaction transitions and dynamic transcriptional bursting during stem cell differentiation in vivo

    Dennis May, Sangwon Yun ... Valentina Greco
    Chromatin gradually rearranges during epidermal stem cell differentiation, while transcription of a differentiation-associated gene is extremely dynamic.
    1. Developmental Biology
    2. Physics of Living Systems

    Controlling periodic long-range signalling to drive a morphogenetic transition

    Hugh Z Ford, Angelika Manhart, Jonathan R Chubb
    Cells control signal circulation to set the frequency of information transmitted over tissue scales.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The lingering effects of Neanderthal introgression on human complex traits

    Xinzhu Wei, Christopher R Robles ... Sriram Sankararaman
    1. Developmental Biology
    2. Neuroscience

    Context-dependent requirement of G protein coupling for Latrophilin-2 in target selection of hippocampal axons

    Daniel T Pederick, Nicole A Perry-Hauser ... Liqun Luo
    1. Genetics and Genomics

    Native functions of short tandem repeats

    Shannon E Wright, Peter K Todd
    The mechanisms by which non-pathologic short tandem repeats normally influence gene expression and engender rapid genetic variation across phylogeny directly inform how expansions in these same repeats elicit neurological disease.
    1. Developmental Biology
    2. Evolutionary Biology

    Ectodermal Wnt signaling, cell fate determination, and polarity of the skate gill arch skeleton

    Jenaid M Rees, Victoria A Sleight ... J Andrew Gillis
    Spatially distinct ectodermal Wnt and endodermal Shh signals serve to polarize the skate gill skeleton.
    1. Structural Biology and Molecular Biophysics

    Ion permeation pathway within the internal pore of P2X receptor channels

    Stephanie W Tam, Kate Huffer ... Kenton J Swartz
    Mapping the ion permeation pathway within the internal pore of ATP-activated P2X receptor channels.
    1. Cell Biology

    Actin-regulated Siglec-1 nanoclustering influences HIV-1 capture and virus-containing compartment formation in dendritic cells

    Enric Gutiérrez-Martínez, Susana Benet Garrab ... Maria F Garcia-Parajo
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Magazine

  1. A large Aedes aegypti mosquito on a green and yellow background; on its left is a group of five smaller mosquitoes and on its right is a bright yellow light bulb

    Community Engagement: Listen to the shopkeeper

    Rafael Maciel-de-Freitas
    1. Genetics and Genomics

    Genetics: The next step in Mendelian randomization

    Matthias Weith, Andreas Beyer
    1. Ecology
    2. Epidemiology and Global Health

    Antibiotic Resistance: A mobile target

    Carolina Oliveira de Santana, Pieter Spealman, Gabriel G Perron
  4. A line-drawn gloved hand holding a scarlet spark against a white background

    Science and Politics: Mexican researchers fear for the future

    1. Developmental Biology
    2. Evolutionary Biology

    Metamorphosis: The making of a maggot brain

    Andreas S Thum, Bertram Gerber

  6. Episode 85: February 2023

    1. Developmental Biology
    2. Plant Biology

    Floral Maturation: How the sunflower gets its rings

    Young-Joon Park, Pil Joon Seo
  8. See more Magazine articles

Research categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
  16. Plant Biology
  17. Stem Cells and Regenerative Medicine
  18. Structural Biology and Molecular Biophysics
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