Latest research

1. 1. Chromosomes and Gene Expression

   Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer

   Jennifer Munkley et al.

   The male steroid hormone testosterone regulates splicing patterns by controlling the expression of a key splicing regulator protein.
2. 1. Cell Biology

   Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division

   Kie Itoh et al.
3. 1. Immunology and Inflammation

   Natural Tr1-like cells do not confer long-term tolerogenic memory

   Koshika Yadava et al.

   Natural Tr1-like cells do not form a functionally stable memory response to allergens, and this instability may limit efforts to re-establish tolerance by expanding Tr1.
4. 1. Neuroscience

   Brian 2, an intuitive and efficient neural simulator

   Marcel Stimberg et al.

   Brian 2 is a software package for neural simulations that makes it both easy and computationally efficient to define original models for computational experiment.
5. 1. Developmental Biology

   N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration

   Elif Kon et al.

   FGFRs regulate multipolar cortical neuron orientation and the morphological change into bipolar cells in vivo under the control of N-Cadherin and the extracellular matrix protein Reelin.
6. 1. Cell Biology
   2. Evolutionary Biology

   The regulation of oocyte maturation and ovulation in the closest sister group of vertebrates

   Shin Matsubara et al.

   Oocyte maturation and ovulation in the sister group of vertebrates, Ciona intestinalis Type A, are triggered by Ci-VP, the Ciona homolog of a typical neruopeptide, vasopressin.
7. 1. Chromosomes and Gene Expression

   CTCF confers local nucleosome resiliency after DNA replication and during mitosis

   Nick Owens et al.
8. 1. Cell Biology

   Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress

   Abigail Buchwalter et al.
9. 1. Cell Biology
   2. Developmental Biology

   BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis

   Hyung-Seok Kim et al.

   Endogenous BMP2/7 and BMP4/7 heterodimers form in vivo, and are the predominant functional ligand in many, if not all, tissues of developing mouse embryos.
10. 1. Neuroscience

    A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in mammalian brain neurons

    Jie-Xian Dong et al.

    Nanobodies are developed that target neuronal proteins with restricted subcellular distributions and used as intrabodies to deliver cargo to specific sites within neurons and nanoscale immunolabels for improved imaging resolution.