Latest research

1. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer

   Yun Pyo Kang et al.

   By increasing intracellular cysteine levels, NRF2 engages a tumor suppressive metabolic pathway mediated by cysteine dioxygenase 1.
2. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   Ion counting demonstrates a high electrostatic field generated by the nucleosome

   Magdalena Gebala et al.

   First experimental studies on the ion atmosphere around a nucleosome provide a quantitative analysis of the molecule's electrostatic properties.
3. 1. Neuroscience

   A connectional hub in the rostral anterior cingulate cortex links areas of emotion and cognitive control

   Wei Tang et al.
4. 1. Cancer Biology

   Replication Study: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

   Anthony Essex et al.

   Editors' Summary: This Replication Study has reproduced important parts of the original paper.
5. 1. Neuroscience

   Inhibitory muscarinic acetylcholine receptors enhance aversive olfactory learning in adult Drosophila

   Noa Bielopolski et al.
6. 1. Microbiology and Infectious Disease

   Silencing cryptic specialized metabolism in Streptomyces by the nucleoid-associated protein Lsr2

   Emma J Gehrke et al.

   In Streptomyces, the nucleoid-associated protein Lsr2 functions as a xenogenic silencer of foreign genes, and as a metabolic gatekeeper, repressing expression of both cryptic and well-studied specialized metabolic biosynthetic clusters.
7. 1. Microbiology and Infectious Disease

   HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors

   Pratibha C Koneru et al.

   Pyridine-based allosteric inhibitors selectively target HIV-1 integrase tetramers and exhibit enhanced antiviral activity against a dolutegravir resistant mutant virus indicating potential clinical benefits for combining these two classes of inhibitors.
8. 1. Neuroscience

   Slow presynaptic mechanisms that mediate adaptation in the olfactory pathway of Drosophila

   Carlotta Martelli, André Fiala

   Slow presynaptic depression in olfactory receptor neurons rescales combinatorial odor representations in postsynaptic neurons and mediates the encoding of stimulus mean and variance.
9. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Cretaceous dinosaur bone contains recent organic material and provides an environment conducive to microbial communities

   Evan T Saitta et al.

   Subterranean fossil bone hosts a living microbiome different from the surrounding sediment without evidence of original protein preservation.
10. 1. Human Biology and Medicine
    2. Neuroscience

    Family history of Alzheimer's disease alters cognition and is modified by medical and genetic factors

    Joshua S Talboom et al.