Latest research

1. 1. Biochemistry and Chemical Biology
   2. Human Biology and Medicine

   GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients

   Xuchen Hu et al.

   The expression of the lipoprotein lipase (LPL) transporter GPIHBP1 in glioma capillaries promotes the LPL-mediated processing of triglyceride-rich lipoproteins, thereby providing lipid nutrients for glioma cells.
2. 1. Cell Biology
   2. Neuroscience

   Pregnancy-associated plasma protein-aa supports hair cell survival by regulating mitochondrial function

   Mroj Alassaf et al.

   Hair cell survival and mitochondrial function is supported by an extracellular stimulator of IGF1 signaling, the protease pregnancy-associated plasma protein-aa.
3. 1. Structural Biology and Molecular Biophysics

   Cystic fibrosis drug ivacaftor stimulates CFTR channels at picomolar concentrations

   László Csanády, Beáta Töröcsik

   Aqueous solubility of cystic fibrosis drug ivacaftor is ~200-fold lower, whereas the potency of its stimulatory effect on the CFTR channel is >100-fold higher, than reported, and is fully reversible.
4. 1. Neuroscience

   Transitioning between preparatory and precisely sequenced neuronal activity in production of a skilled behavior

   Vamsi K Daliparthi et al.

   Precisely sequenced patterns of neuronal activity associated with the production of a skilled behavior begin and end as part of orchestrated activity across functionally diverse populations of cortical premotor neurons.
5. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Epithelial geometry regulates spindle orientation and progenitor fate during formation of the mammalian epidermis

   Kimberly Box et al.

   Early in mammalian epidermal development, basal epidermal progenitor cells utilize packing and three-dimensional geometry, rather than cortical polarity cues, to inform division orientation and progenitor cell fate.
6. 1. Microbiology and Infectious Disease

   CCL2 mobilizes ALIX to facilitate Gag-p6 mediated HIV-1 virion release

   David O Ajasin et al.

   Effect of CCL2 on HIV-1 replication is mediated by mobilization of ALIX from F-actin leading to enhanced virion release and improved fitness and this requires the Gag late motif, LYPX.
7. 1. Cell Biology
   2. Developmental Biology

   Vps8 overexpression inhibits HOPS-dependent trafficking routes by outcompeting Vps41/Lt

   Péter Lőrincz et al.

   Recruitment of HOPS tethering complex to target membranes to promote vesicle fusions requires proper complex assembly and specific small GTPases, and HOPS is not transformed from the related miniCORVET complex.
8. 1. Neuroscience

   'Online' integration of sensory and fear memories in the rat medial temporal lobe

   Francesca S Wong et al.

   Elements of a past sensory memory are incorporated into a new fear memory, and in this way, a stimulus never paired with danger becomes frightening.
9. 1. Immunology and Inflammation

   Circulating T cell-monocyte complexes are markers of immune perturbations

   Julie G Burel et al.

   Human blood contains T cell-monocyte complexes which are not technical artefacts but reflect true in vivo immune cell interactions.
10. 1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Massive antibody discovery used to probe structure–function relationships of the essential outer membrane protein LptD

    Kelly M Storek et al.

    Dispensable loops shield the functionally-important extracellular loops of the essential Gram-negative bacterial outer membrane protein LptD from antibody interference.