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Latest research

    1. Computational and Systems Biology

    Focal seizures are organized by feedback between neural activity and ion concentration changes

    Damiano Gentiletti et al.
    Biophysically realistic computational model reveals how inhibitory interneurons initiate paroxysmal discharges and how changes in the ionic concentrations shape electrographic features of human seizures.
    1. Cancer Biology
    2. Cell Biology

    Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression

    Qiangqiang Liu et al.
    SIAH2 and OTUD5 orchestrate DBC1 ubiquitination and degradation under hypoxic conditions.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase

    Ryo Fujisawa et al.
    UBX proteins reduce the ubiquitin threshold of mammalian p97-UFD1-NPL4.
    1. Developmental Biology

    Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers

    Qiyan Mao et al.
    In vitro grown human muscle fibers display remarkable self-organisation capacities at the tissue, cellular, and molecular levels that are coordinated by mechanical tension.
    1. Developmental Biology
    2. Genetics and Genomics

    Feedback between a retinoid-related nuclear receptor and the let-7 microRNAs controls the pace and number of molting cycles in C. elegans

    Ruhi Patel et al.
    A genetic oscillator composed of NHR-23 and let-7 family of microRNAs links the molting cycle timer and the heterochronic pathway to regulate the pace of molting in C. elegans and ensure that worms molt only four times.