Latest research

1. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1

   Xiaocheng Zhao et al.

   The cAMP-dependent protein kinase A controls the switch from actively sprouting new blood vessel formation to vessel quiescence by reducing endothelial autophagy through phosphorylation-mediated destabilisation of ATG16L1.
2. 1. Microbiology and Infectious Disease

   Sexual transmission of murine papillomavirus (MmuPV1) in Mus musculus

   Megan E Spurgeon, Paul F Lambert

   MmuPV1, a papillomavirus that infects laboratory mice (Mus musculus), is discovered to be sexually transmitted, providing a new animal virus model to study sexually transmitted human papillomaviruses (HPVs).
3. 1. Neuroscience

   Distinct recruitment of dorsomedial and dorsolateral striatum erodes with extended training

   Youna Vandaele et al.
4. 1. Computational and Systems Biology
   2. Evolutionary Biology

   ASPEN, a methodology for reconstructing protein evolution with improved accuracy using ensemble models

   Roman Sloutsky, Kristen M Naegle

   Using different sets of input sequences to evolutionary reconstruction algorithms results in the exploration of many possible models, the intergration over which produces significantly more accurate models.
5. 1. Human Biology and Medicine

   Obesity-linked suppression of membrane-bound O-Acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease

   Robert N Helsley et al.
6. 1. Biochemistry and Chemical Biology

   Identification of an allosteric binding site on the human glycine transporter, GlyT2, for bioactive lipid analgesics

   Shannon N Mostyn et al.

   Identification of how bioactive lipids bind and inhibit glycine transporters has the potential to be exploited in the development of a new class of analgesics for chronic pain.
7. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Control of RNA viruses in mosquito cells through the acquisition of vDNA and endogenous viral elements

   Michel Tassetto et al.

   Virus infection in mosquitoes initiates a highly discriminatory process in which fragments of viral RNA are reverse transcribed to create DNA copies that serve as templates of small antiviral RNAs.
8. 1. Neuroscience

   During hippocampal inactivation, grid cells maintain synchrony, even when the grid pattern is lost

   Noam Almog et al.

   Grid cells lose their hexagonality during hippocampal inactivation, but maintain temporal and spatial synchrony between pairs of cells, implying that hippocampus does not determine phase relations between grid cells.
9. 1. Developmental Biology
   2. Human Biology and Medicine

   Targeting the vascular-specific phosphatase PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma

   Benjamin R Thomson et al.
10. 1. Developmental Biology
    2. Microbiology and Infectious Disease

    Cytoplasmic retention and degradation of a mitotic inducer enable plant infection by a pathogenic fungus

    Paola Bardetti et al.