Latest research

1. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism

   Dylan Gerard Ryan et al.

   Multi-omic analyses reveal a connection between the integrated stress response and the regulation of redox and amino acid metabolism when the TCA cycle is impaired.
2. 1. Genetics and Genomics
   2. Neuroscience

   Enrichment of SARM1 alleles encoding variants with constitutively hyperactive NADase in patients with ALS and other motor nerve disorders

   Jonathan Gilley et al.

   Rare SARM1 alleles encoding SARM1 variants that have constitutively high NADase activity and sensitise cultured neurons to mild stress are risk alleles for ALS and other, related motor disorders.
3. 1. Developmental Biology
   2. Physics of Living Systems

   Mechanism of life-long maintenance of neuron identity despite molecular fluctuations

   Joleen JH Traets et al.

   Differential binding kinetics of a master regulator to its target promoters can prevent spontaneous cell fate loss in a Caenorhabditis elegans neuron whose fate is controlled by a reversible switch.
4. 1. Neuroscience

   Gated recurrence enables simple and accurate sequence prediction in stochastic, changing, and structured environments

   Cédric Foucault, Florent Meyniel

   Small gated recurrent neural networks can dynamically adapt to inferred changes in the environment, represent and use the precision of their estimate to weight their updates, and leverage the environment's latent hierarchical structure, like the Bayesian agent and the brain.
5. 1. Neuroscience

   Synaptic mechanisms of top-down control in the non-lemniscal inferior colliculus

   Hannah M Oberle et al.

   Optogenetic and electrophysiological experiments show how a behaviorally relevant 'feedback' pathway from auditory cortex controls neural activity in the inferior colliculus, an auditory midbrain region important for processing complex time-varying sounds such as speech.
6. 1. Developmental Biology

   Tracking cell lineages in 3D by incremental deep learning

   Ko Sugawara et al.

   Incremental deep learning enables accurate tracking of cell lineages in 3D with a modest investment in time and effort.
7. 1. Evolutionary Biology
   2. Genetics and Genomics

   Unique structure and positive selection promote the rapid divergence of Drosophila Y chromosomes

   Ching-Ho Chang et al.
8. 1. Plant Biology

   Plant trans-golgi network/early endosome pH regulation requires cation chloride cotransporter (CCC1)

   Daniel Walter McKay et al.
9. 1. Cell Biology
   2. Plant Biology

   Regulation of immune receptor kinase plasma membrane nanoscale organization by a plant peptide hormone and its receptors

   Julien Gronnier et al.
10. 1. Neuroscience

    Increasing stimulus similarity drives nonmonotonic representational change in hippocampus

    Jeffrey Wammes et al.

    Hippocampal learning in dentate gyrus follows a U-shaped function, with moderate, but not high or low, overlap between representations leading to differentiation of neural patterns.