Latest research

1. 1. Cell Biology
   2. Microbiology and Infectious Disease

   Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2

   Melissa Kane et al.

   Comprehensive investigation reveals the variability and importance of the nuclear pore complex in HIV-1 infection and the activity of the antiretroviral protein, MX2.
2. 1. Neuroscience

   Functional heterogeneity within the rodent lateral orbitofrontal cortex dissociates outcome devaluation and reversal learning deficits

   Marios C Panayi, Simon Killcross

   The rodent orbitofrontal cortex makes functionally distinct contributions to flexible behavioural control, even within a single putative orbitofrontal subregion, which has important implications for establishing homology between rodent and primate orbitofrontal cortex.
3. 1. Cell Biology

   Autophagy-dependent ribosomal RNA degradation is essential for maintaining nucleotide homeostasis during C. elegans development

   Yubing Liu et al.

   Embryonic development requires autophagy-dependent degradation of ribosomal RNAs.
4. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Human axial progenitors generate trunk neural crest cells in vitro

   Thomas JR Frith et al.

   Pluripotent stem cell differentiation provides insight into how neural crest subtypes of distinct axial identity are patterned in human embryos.
5. 1. Evolutionary Biology

   Fitness effects of altering gene expression noise in Saccharomyces cerevisiae

   Fabien Duveau et al.
6. 1. Genetics and Genomics

   Background selection and biased gene conversion affect more than 95% of the human genome and bias demographic inferences

   Fanny Pouyet et al.
7. 1. Neuroscience

   Building a functional connectome of the Drosophila central complex

   Romain Franconville et al.
8. 1. Neuroscience

   MDN brain descending neurons coordinately activate backward and inhibit forward locomotion

   Arnaldo Carreira-Rosario et al.

   A brain descending interneuron can coordinate a switch between two antagonistic behaviors (forward and backward locomotions).
9. 1. Biochemistry and Chemical Biology

   A discriminator code–based DTD surveillance ensures faithful glycine delivery for protein biosynthesis in bacteria

   Santosh Kumar Kuncha et al.

   Using bioinformatic and biochemical approaches, the study has explained the discriminator base anomaly in bacterial tRNA(Gly) through identification of the key determinant of DTD specificity.
10. 1. Neuroscience

    MAPLE (Modular Automated Platform for Large-scale Experiments), a robot for integrated organism-handling and phenotyping

    Tom Alisch et al.