Latest research

1. 1. Developmental Biology and Stem Cells
   2. Neuroscience

   Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival

   Eleni Kougioumtzidou et al.

   Electrically active axons in white matter stimulate their own myelination by releasing glutamate, which signals through AMPA-type glutamate receptors on nearby oligodendrocyte precursors and newly-differentiating oligodendrocytes, enhancing their survival and hence their ability to myelinate.
2. 1. Immunology

   Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses

   Wei Liu et al.

   CypA boosts RIG-I-mediated antiviral immune responses via enhancing K63-linked ubiquitination of RIG-I and inhibiting K48-linked ubiquitination of MAVS.
3. 1. Genes and Chromosomes
   2. Neuroscience

   Longitudinal imaging of Caenorhabditis elegans in a microfabricated device reveals variation in behavioral decline during aging

   Matthew A Churgin et al.

   The WorMotel, a novel microfabricated device for automated longitudinal imaging of aging in large numbers of Caenorhabditis elegans, reveals that long and short lived strains vary in their behavioral decline during aging in a similar way to the long and short lived individuals in a wild type population.
4. 1. Cell Biology
   2. Developmental Biology and Stem Cells

   Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts

   Max Werth et al.

   A combination of genetic and molecular assays revealed that transcription factor Tfcp2l1 provides the basis for cell patterning and physiologic coordination in kidney collecting ducts.
5. 1. Cell Biology

   Homeostatic control of START through negative feedback between Cln3-Cdk1 and Rim15/Greatwall kinase in budding yeast

   Nicolas Talarek et al.

   Inhibition ofphosphatases by kinases develops Whi5 phosphorylation and cell cycle function inlow cyclin-dependent kinase activity.
6. 1. Biochemistry
   2. Biophysics and Structural Biology

   Tandem hnRNP A1 RNA recognition motifs act in concert to repress the splicing of survival motor neuron exon 7

   Irene Beusch et al.
7. 1. Neuroscience

   The Na⁺/Ca²⁺, K⁺ exchanger NCKX4 is required for efficient cone-mediated vision

   Frans Vinberg et al.
8. 1. Biochemistry

   LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs

   Sungki Hong et al.

   LARP1 turns off and on the translation of an essential class of mRNAs by acting as a key effecter and regulator for mTORC1.
9. 1. Biochemistry

   Serine ADP-ribosylation reversal by the hydrolase ARH3

   Ivan Ahel et al.
10. 1. Neuroscience

    Serial, parallel and hierarchical decision making in primates

    Ariel Zylberberg et al.

    A comparison between hierarchical and flat models of decision-making refutes flat models because they lack flexibility and are not supported by behavioral and neural data.