Latest research

1. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Panproteome-wide analysis of antibody responses to whole cell pneumococcal vaccination

   Joseph J Campo et al.

   Panproteome array analysis of antibody responses to a pneumococcal whole cell vaccine reveals consistent induction of immune responses to multiple surface proteins, despite individuals' unique pre-existing antibody profiles.
2. 1. Microbiology and Infectious Disease

   Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite Plasmodium cynomolgi during progression into dormancy

   Nicole L Bertschi et al.

   Transcriptome profiling of malaria liver-stage parasites provides unprecedented knowledge on genes and pathways expressed in truly dormant hypnozoites and indicates that dormancy is associated with a switch in energy metabolism.
3. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   CtIP forms a tetrameric dumbbell-shaped particle which bridges complex DNA end structures for double-strand break repair

   Oliver J Wilkinson et al.

   Structural and biochemical analysis of human CtIP provides new insights into DNA break recognition, binding and bridging during homologous recombination.
4. 1. Chromosomes and Gene Expression

   PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells

   Shuchi Agrawal Singh et al.

   A key transcription-factor for osteogenic differentiation, PLZF, acts as a transcriptional activator by binding to active developmental enhancers and facilitates mediator recruitment, but is not involved in enhancer looping.
5. 1. Cell Biology

   The Mitotic Exit Network integrates temporal and spatial signals by distributing regulation across multiple components

   Ian Winsten Campbell et al.
6. 1. Cell Biology

   Dynein-mediated transport and membrane trafficking control PAR3 polarised distribution

   Julie Jouette et al.
7. 1. Neuroscience

   S-cone photoreceptors in the primate retina are functionally distinct from L and M cones

   Jacob Baudin et al.

   Heterogeneity in perceptual sensitivity of human cone-mediated vision across wavelength originates in the cone photoreceptors, where S cones exhibit distinct functional properties in comparison to L and M cones.
8. 1. Neuroscience

   Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin

   Michelle S Erwig et al.

   Mature myelin sheaths are scaffolded by the anillin-dependent assembly of septin filaments, thereby facilitating rapid nerve conduction in the healthy CNS.
9. 1. Cell Biology
   2. Microbiology and Infectious Disease

   HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the Nuclear Pore Complex

   David Alejandro Bejarano et al.
10. 1. Plant Biology

    Identification and characterisation of hypomethylated DNA loci controlling quantitative resistance in Arabidopsis

    Leonardo Furci et al.

    Analysis of epigenetic recombinant inbred lines of Arabidopsis identified four hypomethylated DNA loci controlling quantitative disease resistance, which is associated with genome-wide priming of defence genes without affecting plant growth.