Latest research

1. 1. Structural Biology and Molecular Biophysics

   Structure of the human epithelial sodium channel by cryo-electron microscopy

   Sigrid Noreng et al.

   The first structure of the human epithelial sodium channel provides vital insight into the assembly, stoichiometry and molecular mechanism of the ion channel central to sodium homeostasis.
2. 1. Structural Biology and Molecular Biophysics

   Specific structural elements of the T-box riboswitch drive the two-step binding of the tRNA ligand

   Jiacheng Zhang et al.

   The glycine T-box riboswitch recognizes tRNAgly and senses its aminoacylation state by first interacting with the anticodon region and subsequently probing the 3' end of the ligand using both specific structural elements and conformational dynamics.
3. 1. Cell Biology
   2. Physics of Living Systems

   Morphogenetic degeneracies in the actomyosin cortex

   Sundar Ram Naganathan et al.
4. 1. Neuroscience

   Entrainment and maintenance of an internal metronome in supplementary motor area

   Jaime Cadena-Valencia et al.
5. 1. Neuroscience

   Multiple neurons encode CrebB dependent appetitive long-term memory in the mushroom body circuit

   Yves F Widmer et al.
6. 1. Neuroscience

   Lamina-specific cortical dynamics in human visual and sensorimotor cortices

   James J Bonaiuto et al.

   Cortical oscillations in human MEG are lamina-specific, with low-frequency activity predominating in deep, and high-frequency activity in more superficial layers of sensory and motor cortices.
7. 1. Microbiology and Infectious Disease
   2. Plant Biology

   A Phytophthora effector recruits a host cytoplasmic transacetylase into nuclear speckles to enhance plant susceptibility

   Haiyang Li et al.
8. 1. Biochemistry and Chemical Biology

   Affinity capture of polyribosomes followed by RNAseq (ACAPseq), a discovery platform for protein-protein interactions

   Xi Peng et al.

   Affinity capture of polyribosomes followed by RNAseq(ACAPSeq) is a technique that harnesses massively parallel sequencing to identify protein-protein interactions from any source from which polyribosomes can be purified.
9. 1. Neuroscience

   Environmental deformations dynamically shift the grid cell spatial metric

   Alexandra T Keinath et al.
10. 1. Structural Biology and Molecular Biophysics

    Calcium-dependent electrostatic control of anion access to the pore of the calcium-activated chloride channel TMEM16A

    Andy KM Lam, Raimund Dutzler

    Ion conduction in the calcium-activated chloride channel TMEM16A is directly regulated by calcium, which binds to a site close to the pore thereby shaping the electrostatics at its intracellular entrance.