Latest research

1. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia

   Margaret AM Nelson et al.

   Across a physiological span of ATP-free energy, leukemic mitochondria primarily consume, rather than produce, ATP.
2. 1. Epidemiology and Global Health

   Modeling the impact of racial and ethnic disparities on COVID-19 epidemic dynamics

   Kevin C Ma et al.

   Racial and ethnic disparities in SARS-CoV-2 infection rates can impact overall epidemic dynamics and herd immunity, underscoring the need to develop socially informed transmission models that account for population variability.
3. 1. Cell Biology
   2. Physics of Living Systems

   Variations of intracellular density during the cell cycle arise from tip-growth regulation in fission yeast

   Pascal D Odermatt et al.

   The density of the cytoplasm in S. pombe varies in time and space during the cell cycle through modulation of tip growth rate coupled with constant mass growth rate.
4. 1. Biochemistry and Chemical Biology
   2. Neuroscience

   Multiple pathways of toxicity induced by C9orf72 dipeptide repeat aggregates and G₄C₂ RNA in a cellular model

   Frédéric Frottin et al.

   Protein aggregates resulting from mutations in C9orf72 impair different aspects of cellular quality control in the cytosol and the nucleus, but mRNA-mediated effects contribute more strongly to toxicity.
5. 1. Plant Biology

   A hypothesis on the capacity of plant odorant-binding proteins to bind volatile isoprenoids based on in silico evidences

   Deborah Giordano et al.

   It is hypothesized that volatile organic compounds emitted by plants after stress induction may be sensed by neighboring eavesdropping plants using odorant-binding proteins.
6. 1. Cancer Biology

   Exosome component 1 cleaves single-stranded DNA and sensitizes kidney renal clear cell carcinoma cells to poly(ADP-ribose) polymerase inhibitor

   Qiaoling Liu et al.
7. 1. Medicine

   Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption

   Cheng-Chia Tang et al.
8. 1. Genetics and Genomics

   Loss of heterozygosity results in rapid but variable genome homogenization across genetic backgrounds in yeast

   Abhishek Dutta et al.
9. 1. Epidemiology and Global Health

   Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection

   Allison Koenecke et al.

   Patients exposed to ⍺1-AR antagonists have reduced risks of mechanical ventilation and death in lower respiratory tract infection-related illnesses, highlighting the need for prospective trials assessing ⍺1-AR antagonists' effectiveness in COVID-19.
10. 1. Developmental Biology
    2. Plant Biology

    Organ geometry channels reproductive cell fate in the Arabidopsis ovule primordium

    Elvira Hernandez-Lagana et al.

    In the Arabidopsis ovule primordium, germinal fate plasticity is coupled to the morphogenetic processes shaping the organ.