Latest research

1. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Mycobacterium tuberculosis induces decelerated bioenergetic metabolism in human macrophages

   Bridgette M Cumming et al.
2. 1. Cell Biology
   2. Developmental Biology

   Angiopoietin-4-dependent venous maturation and fluid drainage in the peripheral retina

   Harri Elamaa et al.

   Identification of importance of Angiopoietin-4 (Angpt4) as a first growth factor that initiates venous specification in the peripheral retina, and Angpt4-dependent mechanism for fluid clearance in the mouse retina.
3. 1. Structural Biology and Molecular Biophysics

   Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core

   Andrew J Borst et al.

   An integrative structural and biophysical workflow indicates engagement of VRC01 germline antibodies can occur with a gp120 426c core construct containing all wild-type N-linked glycosylation sites, including the Asn276 glycan.
4. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   Integrated culturing, modeling and transcriptomics uncovers complex interactions and emergent behavior in a three-species synthetic gut community

   Kevin D'hoe et al.

   Human gut bacteria alter their metabolism in response to each other's presence, which causes their community dynamics to deviate from predictions that are based on mono-culture data.
5. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma

   Gerard L Brien et al.
6. 1. Structural Biology and Molecular Biophysics

   Cryo-EM structure of the mechanically activated ion channel OSCA1.2

   Sebastian Jojoa-Cruz et al.

   Structures of OSCA1.2, a member of a newly characterized family of mechanically activated ion channels, provide insights into mechanism of channel gating by membrane tension.
7. 1. Evolutionary Biology
   2. Structural Biology and Molecular Biophysics

   OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels

   Swetha E Murthy et al.

   A family of proteins (OSCA/TMEM63) that encode mechanosensitive ion channels has been characterized in plants, flies, and mammals.
8. 1. Computational and Systems Biology
   2. Neuroscience

   Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model

   Daniel B Dorman et al.

   Inhibition enhances the spatial specificity of high calcium influx for cooperatively stimulated synapses, suggesting that inhibitory inputs may regulate both synapse-specific and heterosynaptic plasticity to support learning and memory.
9. 1. Microbiology and Infectious Disease

   Genetic basis for coordination of meiosis and sexual structure maturation in Cryptococcus neoformans

   Linxia Liu et al.

   Meiosis and differentiation of basidium, a defining sexual structure of the phylum Basidiomycota, are genetically integrated by a shared regulatory program to ensure the formation of infectious meiospores in Cryptococcus neoformans.
10. 1. Biochemistry and Chemical Biology
    2. Plant Biology

    Effects of microcompartmentation on flux distribution and metabolic pools in Chlamydomonas reinhardtii chloroplasts

    Anika Küken et al.

    Mathematical models reveal that under the physiologically different conditions ambient and high CO2, two algal microcompartments are metabolically connected by facilitated transport.