Latest research

1. 1. Neuroscience

   Enhanced excitability of cortical neurons in low-divalent solutions is primarily mediated by altered voltage-dependence of voltage-gated sodium channels

   Briana J Martiszus et al.

   External calcium regulates neuronal excitability via its actions on voltage-gated sodium channels but not by regulating NALCN via the calcium-sensing receptor.
2. 1. Medicine
   2. Neuroscience

   Recovery of consciousness and cognition after general anesthesia in humans

   George A Mashour et al.

   Cognitive reconstitution after pharmacologic unconsciousness is an extended process, executive function is more robust than expected, and the healthy human brain is resilient to the effects of deep general anesthesia.
3. 1. Ecology
   2. Microbiology and Infectious Disease

   A novel ATP dependent dimethylsulfoniopropionate lyase in bacteria that releases dimethyl sulfide and acryloyl-CoA

   Chun-Yang Li et al.

   A novel dimethylsulfoniopropionate lyase was identified, which catalyzes dimethyl sulfide releasing by a new mechanism and is found in several bacterial lineages, revealing its important roles in global sulfur cycling.
4. 1. Cancer Biology
   2. Cell Biology

   PHAROH lncRNA regulates Myc translation in hepatocellular carcinoma via sequestering TIAR

   Allen T Yu et al.

   PHAROH lncRNA is upregulated in hepatocellular carcinoma and functions by sequestering the translational suppressor TIAR via a 71 nucleotide hairpin to regulate c-MYC translation.
5. 1. Neuroscience

   Dopamine differentially modulates the size of projection neuron ensembles in the intact and dopamine-depleted striatum

   Marta Maltese et al.

   In addition to modulating firing rates, the neurotransmitter dopamine exerts a strong influence on the overall number of neurons in striatum that are recruited during behavior.
6. 1. Neuroscience

   Linguistic processing of task-irrelevant speech at a cocktail party

   Paz Har-shai Yahav, Elana Zion Golumbic

   Syntactic structure-building processes can be applied to speech that is task-irrelevant and should be ignored, demonstrating that Selective Attention does not fully eliminate linguistic processing of competing speech.
7. 1. Genetics and Genomics
   2. Medicine

   A Mendelian randomization study of the role of lipoprotein subfractions in coronary artery disease

   Qingyuan Zhao et al.

   High-density lipoprotein (HDL) subfraction traits appear to have heterogeneous effects on coronary artery disease, giving support to the HDL function hypothesis.
8. 1. Medicine

   Development and validation of a nomogram to better predict hypertension based on a 10-year retrospective cohort study in China

   Xinna Deng et al.

   A developed and validated nomogram better predicts the risk of hypertension based on a 10-year retrospective cohort study in China.
9. 1. Genetics and Genomics
   2. Immunology and Inflammation

   Inflammation drives alternative first exon usage to regulate immune genes including a novel iron regulated isoform of Aim2

   Elektra Kantzari Robinson et al.
10. 1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection

    Tania Lebratti et al.

    Type I IFN is a key determinant of pathogenic neutrophil activity and drives tissue pathology through modulation of IL-18 levels during genital HSV infection.