Latest research

1. 1. Neuroscience

   Apical length governs computational diversity of layer 5 pyramidal neurons

   Alessandro R Galloni et al.

   Layer 5 pyramidal neurons vary substantially in dendritic excitability between primary and secondary visual cortex, likely due to a counterintuitive amplifying effect of long apical dendrites.
2. 1. Human Biology and Medicine

   TMAO, a seafood-derived molecule, produces diuresis and reduces mortality in heart failure rats

   Marta Gawrys-Kopczynska et al.

   Trimethylamine-oxide (TMAO), a molecule present in seafood, reduces mortality and exerts beneficial effects on the circulatory system in heart failure rats.
3. 1. Neuroscience
   2. Physics of Living Systems

   Tuning of feedforward control enables stable muscle force-length dynamics after loss of autogenic proprioceptive feedback

   Joanne C Gordon et al.

   Running guinea fowl maintain stable running after loss of the stretch reflex in a major ankle extensor muscle, by increasing feedforward muscle activation to maintain ankle stiffness and work output.
4. 1. Structural Biology and Molecular Biophysics

   Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity

   Lukas M Langer et al.

   First structural view of a substrate-bound PIKK (PI3K-related-kinase) by cryo-EM explains phosphorylation specificity toward a short amino-acid motif shared across the PIKK family and rationalizes PIKK auto-inhibition by regulatory domain.
5. 1. Neuroscience

   Temporal selectivity declines in the aging human auditory cortex

   Julia Erb et al.
6. 1. Microbiology and Infectious Disease

   Profiling of myristoylation in Toxoplasma gondii reveals an N-myristoylated protein important for host cell penetration

   Malgorzata Broncel et al.
7. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Chemical and structural investigation of the paroxetine-human serotonin transporter complex

   Jonathan A Coleman et al.
8. 1. Neuroscience

   Vestigial auriculomotor activity indicates the direction of auditory attention in humans

   Daniel J Strauss et al.

   Recordings of ear muscles in humans show that ears attempt to pivot in the direction that requires attention.
9. 1. Ecology
   2. Physics of Living Systems

   Ant collective cognition allows for efficient navigation through disordered environments

   Aviram Gelblum et al.

   When real ants confront the classical 'Ant-in-a-labyrinth' physics problem where a random walker traverses a percolated environment, they employ active extended sensing and collective cognition to outperform passive physical solutions.
10. 1. Neuroscience

    Automated task training and longitudinal monitoring of mouse mesoscale cortical circuits using home cages

    Timothy H Murphy et al.

    A new methodology and protocol use automated brain imaging and task training technology to probe links between behavior and mouse cortical circuits.