eLife is an open-access journal that publishes promising research in the life and biomedical sciences

Latest research

    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Rif1 inhibits replication fork progression and controls DNA copy number in Drosophila

    Alexander Munden et al.
    To regulate DNA copy number during development in Drosophila, the SUUR protein recruits Rif1 to replisomes where Rif1 inhibits replication fork progression, thus controlling copy number independently of origin firing.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    New insights into the cellular temporal response to proteostatic stress

    Justin Rendleman et al.
    A time-resolved analysis of protein and RNA concentrations and interactions during proteostasis stress highlights the dominant role of translation regulation and a shift of energy metabolism.
    1. Neuroscience

    ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines

    Shu-Xia Cao et al.
    Behavioral and molecular mechanistic studies elaborate the important role of ErbB4 in noradrenergic neurons associated with mania pathogenesis.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    UBE2G1 governs the destruction of cereblon neomorphic substrates

    Gang Lu et al.
    Cereblon-based small-molecule degraders rely on the sequential action of ubiquitin-conjugating enzymes UBE2G1 and UBE2D3 to assemble K48-linked polyubiquitin chains on cereblon neomorphic substrates, resulting in their proteasomal degradation.
    1. Neuroscience

    Receptive field center-surround interactions mediate context-dependent spatial contrast encoding in the retina

    Maxwell H Turner et al.
    In the retina, the receptive field surround preserves the spatial contrast sensitivity of the center in the face of naturalistic changes in local luminance.