Latest research

1. 1. Neuroscience

   Medical education and distrust modulate the response of insular-cingulate network and ventral striatum in pain diagnosis

   Giada Dirupo et al.

   Behavioral and neural data converge in showing that medical experience reduces reactions to others' pain and distrust toward the target affects the processing of his feedback.
2. 1. Neuroscience

   Robust and distributed neural representation of action values

   Eun Ju Shin et al.

   Action-value signals previously found in many brain areas can be accounted for neither by concurrent serial correlations in neural activity and action value nor by signals for other decision variables.
3. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   CRISPR-based functional genomics in human dendritic cells

   Marco Jost et al.

   A CRISPR-based method enables targeted knockouts and genetic screens in human dendritic cells.
4. 1. Cell Biology

   A robust method for particulate detection of a genetic tag for 3D electron microscopy

   James Rae et al.

   Development of a new system for gold particle detection of a genetic tag for electron microscopy.
5. 1. Chromosomes and Gene Expression
   2. Evolutionary Biology

   Morphological and genomic shifts in mole-rat ‘queens’ increase fecundity but reduce skeletal integrity

   Rachel A Johnston et al.

   In cooperatively breeding Damaraland mole-rats, transitioning to 'queen' results in extensive gene regulatory and morphological remodeling, but also costs to skeletal integrity that scale with reproductive investment.
6. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Co-regulation and function of FOXM1/RHNO1 bidirectional genes in cancer

   Carter J Barger et al.

   FOXM1 is co-expressed with its bidirectional gene partner RHNO1, and the two genes promote DNA repair, cell growth and survival, and chemotherapy resistance in ovarian cancer.
7. 1. Biochemistry and Chemical Biology

   Protomer alignment modulates specificity of RNA substrate recognition by Ire1

   Weihan Li et al.

   Biochemical analysis and computational modeling reveal how cells mechanistically control the quality of their proteomes and demonstrate that the precise alignment of subunits in oligomeric complexes can profoundly affect enzymatic properties.
8. 1. Developmental Biology

   Ongoing repair of migration-coupled DNA damage allows planarian adult stem cells to reach wound sites

   Sounak Sahu et al.

   Adult stem cells acquire increased DNA damage as they migrate to a wound site and require active DNA repair mechanisms for normal migration.
9. 1. Neuroscience

   Creating and controlling visual environments using BonVision

   Gonçalo Lopes et al.

   BonVision is an open-source software for real-time rendering and control of 2D and 3D visual environments that also enables easy replication of experiments.
10. 1. Cell Biology

    SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation

    David W Sanders et al.

    A high-throughput microscopy screen for drugs that modulate SARS-CoV-2 spike-mediated membrane fusion identifies an essential role for cholesterol in both virus entry and syncytia formation.