Latest research

1. 1. Structural Biology and Molecular Biophysics

   Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and nonischemic human hearts

   Maicon Landim-Vieira et al.

   Analytical techniques and computational models reveal novel post-translational modifications on β-myosin heavy chain in the human hearts and highlight their potential as therapeutic targets.
2. 1. Evolutionary Biology
   2. Genetics and Genomics

   Epistatic selection on a selfish Segregation Distorter supergene – drive, recombination, and genetic load

   Beatriz Navarro-Dominguez et al.

   African haplotypes of a meiotic drive supergene in Drosophila melanogaster called Segregation Distorter show signs of a recent selective sweep, reduced recombination, and increased genetic load.
3. 1. Neuroscience

   Human visual gamma for color stimuli

   Benjamin J Stauch et al.

   Colored surfaces induce gamma oscillations in human early visual cortex that are equally strong for red and green colors when L-M cone contrast is controlled for.
4. 1. Stem Cells and Regenerative Medicine

   Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer’s model

   Felicia Reinitz et al.

   A neural precursor cell defect precedes widespread inflammation, amyloid plaque pathology, and cognitive deficit in Alzheimer's disease, which can be reversed by inhibiting USP16.
5. 1. Cell Biology

   C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9

   Saskia-Larissa Jauch-Speer et al.

   A genome-wide CRISPR/Cas9 knockout screening approach identified C/EBPδ as transcriptional regulator of the alarmins S100A8 and S100A9 during differentiation of monocytes and inflammatory processes in vivo.
6. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Doublecortin engages the microtubule lattice through a cooperative binding mode involving its C-terminal domain

   Atefeh Rafiei et al.

   Doublecortin activates its C-terminal domain when its N-terminal domain engages the microtubule lattice, leading to self-associations that explain the stabilizing effect of Doublecortin in neuronal migration.
7. 1. Chromosomes and Gene Expression

   DNA-PK promotes DNA end resection at DNA double strand breaks in G₀ cells

   Faith C Fowler et al.

   Molecular analyses and unbiased CRISPR screens reveal that extensive end resection occurs in quiescent cells after inducing DNA double strand breaks, in a manner dependent on DNA-PK.
8. 1. Structural Biology and Molecular Biophysics

   Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane

   Siyoung Kim et al.

   The functions of seipin in triacylglycerol nucleation and lipid droplet maturation are studied with all-atom and coarse-grained simulations along with cell experiments, providing a novel model for lipid droplet formation.
9. 1. Ecology
   2. Evolutionary Biology

   Parasite defensive limb movements enhance acoustic signal attraction in male little torrent frogs

   Longhui Zhao et al.

   Multimodal signals may evolve from unimodal one via co-option of primary signal components and associated cues that serve as by-products.
10. 1. Developmental Biology

    Visceral organ morphogenesis via calcium-patterned muscle constrictions

    Noah P Mitchell et al.