Latest research

1. 1. Neuroscience

   A transient postnatal quiescent period precedes emergence of mature cortical dynamics

   Soledad Dominguez et al.
2. 1. Genetics and Genomics
   2. Plant Biology

   Repression of CHROMOMETHYLASE 3 prevents epigenetic collateral damage in Arabidopsis

   Ranjith K Papareddy et al.
3. 1. Epidemiology and Global Health
   2. Microbiology and Infectious Disease

   Impact of asymptomatic Plasmodium falciparum infection on the risk of subsequent symptomatic malaria in a longitudinal cohort in Kenya

   Kelsey M Sumner et al.
4. 1. Microbiology and Infectious Disease

   In vivo imaging of retrovirus infection reveals a role for Siglec-1/CD169 in multiple routes of transmission

   Kelsey A Haugh et al.

   Retroviruses exploit the lectin, Siglec-1/CD169, expressed on sentinel macrophages to promote infection during multiple routes of transmission.
5. 1. Structural Biology and Molecular Biophysics

   Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

   Fenghui Zhao et al.

   The structure provides key insights into hormone recognition and activation of the glucose-dependent insulinotropic polypeptide receptor.
6. 1. Cancer Biology
   2. Developmental Biology

   E2F/Dp inactivation in fat body cells triggers systemic metabolic changes

   Maria Paula Zappia et al.

   The E2F/Dp transcription factors, which are key cell cycle regulators, can also mediate the regulation of carbohydrate metabolism in larva by controlling both systemic trehalose homeostasis and fat storage.
7. 1. Neuroscience

   A locomotor neural circuit persists and functions similarly in larvae and adult Drosophila

   Kristen Lee, Chris Q Doe

   Descending interneurons maintain synaptic connectivity and behavioral function despite pruning during metamorphosis, showing that synaptic specificity is established twice at different life stages.
8. 1. Structural Biology and Molecular Biophysics

   Cryo-EM structures of the caspase-activated protein XKR9 involved in apoptotic lipid scrambling

   Monique S Straub et al.

   The cryo-EM structures of XKR9 define the architecture and caspase-mediated activation of a protein family that is involved in the exposure of phosphatidylserine during apoptosis leading to the engulfment of apoptotic cells by macrophages.
9. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   CTP promotes efficient ParB-dependent DNA condensation by facilitating one-dimensional diffusion from parS

   Francisco de Asis Balaguer et al.

   Single-molecule methods reveal that cytidine triphosphate promotes DNA condensation specifically at bacterial centromeres by facilitating one-dimensional diffusion of ParB from parS sites.
10. 1. Neuroscience

    Information flow, cell types and stereotypy in a full olfactory connectome

    Philipp Schlegel et al.

    Synaptic resolution analysis of a full olfactory connectome reveals lateralised circuits, convergence of innate and learned pathways, and shows that homologous neurons are highly stereotyped within and across brains.