Latest research

1. 1. Microbiology and Infectious Disease

   HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors

   Pratibha C Koneru et al.

   Pyridine-based allosteric inhibitors selectively target HIV-1 integrase tetramers and exhibit enhanced antiviral activity against a dolutegravir resistant mutant virus indicating potential clinical benefits for combining these two classes of inhibitors.
2. 1. Neuroscience

   Slow presynaptic mechanisms that mediate adaptation in the olfactory pathway of Drosophila

   Carlotta Martelli, André Fiala

   Slow presynaptic depression in olfactory receptor neurons rescales combinatorial odor representations in postsynaptic neurons and mediates the encoding of stimulus mean and variance.
3. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Cretaceous dinosaur bone contains recent organic material and provides an environment conducive to microbial communities

   Evan T Saitta et al.

   Subterranean fossil bone hosts a living microbiome different from the surrounding sediment without evidence of original protein preservation.
4. 1. Developmental Biology
   2. Evolutionary Biology

   Evolution of limb development in cephalopod mollusks

   Oscar A Tarazona et al.

   Cuttlefish embryos reveal that cephalopod mollusks evolved specialized arms and tentacles by activating the same genetic circuits that control development of limbs in arthropods and vertebrates.
5. 1. Human Biology and Medicine
   2. Neuroscience

   Family history of Alzheimer's disease alters cognition and is modified by medical and genetic factors

   Joshua S Talboom et al.
6. 1. Microbiology and Infectious Disease
   2. Structural Biology and Molecular Biophysics

   Structure of the Helicobacter pylori Cag Type IV secretion system

   Jeong Min Chung et al.
7. 1. Ecology
   2. Evolutionary Biology

   Variable opportunities for outcrossing result in hotspots of novel genetic variation in a pathogen metapopulation

   Anna-Liisa Laine et al.
8. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome

   Jean Paul Armache et al.
9. 1. Cell Biology
   2. Structural Biology and Molecular Biophysics

   A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength

   Benjamin König et al.
10. 1. Structural Biology and Molecular Biophysics

    Mechanism of completion of peptidyltransferase centre assembly in eukaryotes

    Vasileios Kargas et al.

    Cryo-EM reveals how the central functional site of the ribosome is assembled and provides a framework to interpret the consequences of mutations linked to leukaemia-associated ribosomopathies.