The origin of hagfish slime

Latest research

1. 1. Structural Biology and Molecular Biophysics

   Peptides that Mimic RS repeats modulate phase separation of SRSF1, revealing a reliance on combined stacking and electrostatic interactions

   Talia Fargason, Naiduwadura Ivon Upekala De Silva ... Jun Zhang

   Short peptides that mimic the regions responsible for phase separation can be used to solubilize phase-separating proteins in their native states and to determine the mechanism of phase separation.
2. 1. Neuroscience

   CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles

   Brian D Mueller, Sean A Merrill ... Erik M Jorgensen

   The Caenorbhaditis elegans presynapse contains two pools of synaptic vesicles at the active zone, coupled to either neuronal-type or muscle-type calcium channels, and to different docking machinery.
3. 1. Chromosomes and Gene Expression
   2. Developmental Biology

   The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart

   Valeria Taliani, Giulia Buonaiuto ... Monica Ballarino

   The lncRNA pCharme controls the expression of cardiomyocyte maturation genes and heart development by orchestrating the formation of MATR3-enriched nuclear condensates.
4. 1. Cancer Biology

   Kindlin-1 regulates IL-6 secretion and modulates the immune environment in breast cancer models

   Emily R Webb, Georgia L Dodd ... Valerie G Brunton

   New roles in anti-tumour immunity for the adhesion protein Kindlin-1 via regulation of cytokine secretion and T cell regulation.
5. 1. Cell Biology
   2. Neuroscience

   Large vesicle extrusions from C. elegans neurons are consumed and stimulated by glial-like phagocytosis activity of the neighboring cell

   Yu Wang, Meghan Lee Arnold ... Barth D Grant

   Giant neuron derived vesicles called exophers are processed by phagocytosis in neighboring skin cells, and the phagocytic interaction promotes exopher production.
6. 1. Cell Biology
   2. Genetics and Genomics

   Identification of a weight loss-associated causal eQTL in MTIF3 and the effects of MTIF3 deficiency on human adipocyte function

   Mi Huang, Daniel Coral ... Sebastian Kalamajski

   MTIF3 safeguards mitochondrial electron transport chain assembly in adipocytes, and affects thus adipocyte fatty acid oxidation ability, which can explain why MTIF3 genetic variation can influence dietary intervention aimed at weight loss.
7. 1. Epidemiology and Global Health

   Reducing societal impacts of SARS-CoV-2 interventions through subnational implementation

   Mark M Dekker, Luc E Coffeng ... Sake J de Vlas

   An agent-based, population-scale, geographically explicit model, and integration of comprehensive data sources on demography, mobility, interactions and SARS-CoV-2 parameters, show that subnational implementations of intervention measures may provide better strategic choices for controlling future epidemics.
8. 1. Neuroscience

   Netrin-1 regulates the balance of synaptic glutamate signaling in the adult ventral tegmental area

   Marcella M Cline, Barbara Juarez ... Larry S Zweifel

   Genetic analysis of Ntn1 in adult mouse midbrain neurons reveals its function in maintaining excitatory synapses, loss of Ntn1 function in inhibitory neurons is significantly detrimental to mesolimbic system function.
9. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Concurrent remodeling of nucleolar 60S subunit precursors by the Rea1 ATPase and Spb4 RNA helicase

   Valentin Mitterer, Matthias Thoms ... Roland Beckmann
10. 1. Computational and Systems Biology
    2. Neuroscience

    Multilayer brain networks can identify the epileptogenic zone and seizure dynamics

    Hossein Shahabi, Dileep R Nair, Richard M Leahy