Latest research

1. 1. Developmental Biology

   An intrinsic cell cycle timer terminates limb bud outgrowth

   Joseph Pickering et al.

   Size control in limbs is an intrinsically determined process.
2. 1. Developmental Biology
   2. Cell Biology

   Direct visualization of a native Wnt in vivo reveals that a long-range Wnt gradient forms by extracellular dispersal

   Ariel M Pani, Bob Goldstein

   Free, extracellular dispersal of Wnt proteins generates a long-range gradient during animal development and is required for signaling.
3. 1. Genetics and Genomics

   Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability

   Niko Välimäki et al.
4. 1. Developmental Biology
   2. Evolutionary Biology

   CRISPR knockouts reveal an endogenous role for ancient neuropeptides in regulating developmental timing in a sea anemone

   Nagayasu Nakanishi, Mark Q Martindale
5. 1. Neuroscience

   Normal cognitive and social development require posterior cerebellar activity

   Aleksandra Badura et al.
6. 1. Plant Biology

   Anisotropic growth is achieved through the additive mechanical effect of material anisotropy and elastic asymmetry

   Firas Bou Daher et al.

   Growing upwards in the young seedling is controlled by two cooperative mechanical mechanisms: cellulose orientation in inner tissues and differential elasticity in epidermal cells.
7. 1. Ecology

   Experimental evaluation of the importance of colonization history in early-life gut microbiota assembly

   Inés Martínez et al.

   Experiments in ex-germ-free mice establish a measurable effect of colonization history on gut microbiota assembly, illuminating a potential cause for the high levels of unexplained individuality in host-associated microbial communities.
8. 1. Human Biology and Medicine

   Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity

   John B Lees-Shepard et al.

   Daily palovarotene treatment reduces pathogenic expansion of fibro/adipogenic progenitors but results in long bone growth plate loss and overgrowths of synovial cartilage in juvenile mice.
9. 1. Cell Biology
   2. Human Biology and Medicine

   Prolonged cross-bridge binding triggers muscle dysfunction in a Drosophila model of myosin-based hypertrophic cardiomyopathy

   William A Kronert et al.

   Integrative analysis of a Drosophila model of hypertrophic cardiomyopathy demonstrates that prolonged binding of the myosin cross-bridge to actin is a root cause of the disorder.
10. 1. Cell Biology

    PPP1R35 is a novel centrosomal protein that regulates centriole length in concert with the microcephaly protein RTTN

    Andrew Michael Sydor et al.

    The previously uncharacterized protein PPP1R35 is a novel centriolar luminal protein critical for centriole elongation by acting in a complex with microcephaly protein RTTN.