Highlights

  • The evolution of effectors

    Pathogens that cause abnormal growths called galls in plants rely on effector molecules with structures and targeting strategies that are conserved across evolutionary lineages.

    Soham Mukhopadhyay, Muhammad Asim Javed ... Edel Perez-Lopez
    Tools and Resources

  • Modelling archaeal membranes

    Archaea use single-headed and double-headed lipids to construct cell membranes that are both flexible and capable of withstanding extreme environments.

    Miguel Amaral, Felix Frey ... Anđela Šarić
    Research Article

  • No change for astroctyes

    Genetically removing the RNA-binding protein PTBP1 from astrocytes does not convert them into neurons, contrary to previous claims.

    Min Zhang, Naoto Kubota ... Sika Zheng
    Reviewed Preprint Updated

  • Genetic pathways in brown algae

    Life-cycle-related patterns of gene expression are conserved across the brown algae.

    Pélagie Ratchinski, Olivier Godfroy ... J Mark Cock
    Reviewed Preprint Updated

  • Tracing cell fates in embryos

    Differences in the activity of an enzyme called CARM1 influence whether blastomeres become part of the embryo or the placenta.

    Ying Zhang, Qi Chen
    Insight

  • New university partnerships

    eLife is partnering with two leading UK universities on open access agreements that promote a more open and equitable approach to scientific publishing.

    Press Pack
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Ecology

    Early experience affects foraging behavior of wild fruit bats more than their original behavioral predispositions

    Adi Rachum, Lee M Harten ... Yossi Yovel
    Early-life environment shapes how wild bats behave as adults, showing that developmental experience, rather than innate predisposition, drives individual differences in foraging behavior.
    1. Chromosomes and Gene Expression

    Acetylation of H3K115 is associated with fragile nucleosomes at CpG island promoters and active regulatory sites

    Yatendra Kumar, Dipta Sengupta ... Wendy A Bickmore
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Immunology and Inflammation

    Ex vivo and in vivo CRISPR/Cas9 screenings identify the roles of protein N-glycosylation in regulating T-cell activation and functions

    Yu Hong, Xiaofang Si ... Yu Zhang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Dorsal hippocampus mediates light-tone associations in male mice

    Julia S Pinho, Carla Ramon-Duaso ... Arnau Busquets-García
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Medicine

    NAD+ boosting by oral nicotinamide mononucleotide administration regulates key metabolic and immune pathways through SIRT1 dependent and independent mechanisms to mitigate diet-induced obesity and dyslipidemia in mice

    Yasser Majeed, Najeeb M Halabi ... Nayef A Mazloum
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    The inevitability and superfluousness of cell types in spatial cognition

    Xiaoliang Luo, Robert M Mok, Bradley C Love
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Incomplete
    1. Computational and Systems Biology

    Raw signal segmentation for estimating RNA modification from Nanopore direct RNA sequencing data

    Guangzhao Cheng, Aki Vehtari, Lu Cheng
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Developmental Biology

    A tissue boundary orchestrates the segregation of inner ear sensory organs

    Ziqi Chen, Magdalena Żak ... Nicolas Daudet
    A boundary between the sensory and nonsensory domains contains cells that undergo a series of morphological changes and form basal constriction to separate the segregating inner ear sensory organs.
    1. Neuroscience

    Eye-specific differences in active zone addition during synaptic competition in the developing visual system

    Chenghang Zhang, Tarlan Vatan, Colenso M Speer
    Eye-specific differences in presynaptic release site addition and clustering correlate with axonal segregation outcomes during retinogeniculate refinement in the mouse.
    1. Evolutionary Biology

    Parallel HIV-1 fitness landscapes shape viral dynamics in humans and macaques that develop broadly neutralizing antibodies

    Kai S Shimagaki, Rebecca M Lynch, John P Barton
    Fitness constraints on the HIV envelope protein are highly similar in humans and rhesus macaques, emphasizing the utility of macaque models of infection and antibody development.
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Magazine

    1. Medicine
    2. Immunology and Inflammation
    3. Microbiology and Infectious Disease

    Focus Issue: Trained Immunity

    Edited by Satyajit Rath et al.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Focus Issue: Evolving our understanding of trained immunity

    Eva Kaufmann, Yahya Sohrabi ... Jos WM van der Meer
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Bacteriology: How Shigella tackles host defences

    Yizhou Huang, Teresa LM Thurston
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Chromosomes: Exploring a crossroads in the aging process

    Kiyan Shabestary, Daniel E Gottschling
    1. Neuroscience

    Neuronal Migration: How hunger guides new brain cells to their destination

    Fang-Shin Nian, Laurent Nguyen
    1. Neuroscience

    Primate Research: Probing the staying power of chemogenetics

    Maria Puchik, Igor Kagan
    1. Genetics and Genomics
    2. Neuroscience

    Aging: Unlocking the longevity code with stress

    Loren Cocciolone, Valeria Uvarova, Patricija van Oosten-Hawle
  8. See more Magazine articles

Categories

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  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
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  10. Genetics and Genomics
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  12. Medicine
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