eLife works to improve research communication through open science and open technology innovation

Latest research

    1. Evolutionary Biology

    Sequence and structural conservation reveal fingerprint residues in TRP channels

    Deny Cabezas-Bratesco et al.
    Joint sequence, structure, and phylogenetic analyses identify highly conserved features in transmembrane domains of transient receptor potential (TRP) ion channel proteins that offer a novel explanation for how TRPs could integrate stimuli into cellular signals.
    1. Computational and Systems Biology
    2. Neuroscience

    Waveform detection by deep learning reveals multi-area spindles that are selectively modulated by memory load

    Maryam H Mofrad et al.
    A new computational approach for detecting sleep waveforms reveals that the 11–15 Hz sleep 'spindle', a neural rhythm implicated in memory consolidation, co-occurs widely across cortex much more often than previously thought.
    1. Genetics and Genomics

    An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination

    Oguz Kanca et al.
    New construct designs and gene targeting strategies from the Gene Disruption Project allow efficient tagging of almost all Drosophila genes.
    1. Structural Biology and Molecular Biophysics

    All-atom molecular dynamics simulations of Synaptotagmin-SNARE-complexin complexes bridging a vesicle and a flat lipid bilayer

    Josep Rizo et al.
    Novel insights into the molecular mechanisms underlying neurotransmitter release are provided by all-atom molecular dynamics simulations including SNARE proteins, synaptotagmin-1, complexin-1, a vesicle and a flat bilayer.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies

    Ceri Alan Fielding et al.
    SARS-CoV-2 host-shutoff inhibits innate NK surveillance by suppressing activating ligands, however ADCC provides a potent NK stimulus that is mediated by antibodies targeting Nucleocapsid, ORF3a, and Membrane, with those targeting Spike being significantly weaker.
    1. Evolutionary Biology
    2. Medicine

    Evolution-based mathematical models significantly prolong response to abiraterone in metastatic castrate-resistant prostate cancer and identify strategies to further improve outcomes

    Jingsong Zhang et al.
    Integration of evolutionary dynamics framed through a mathematical model improved outcomes in abiraterone monotherapy for the treatment of metastatic castrate-resistant prostate cancer.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Robotic search for optimal cell culture in regenerative medicine

    Genki N Kanda et al.
    Robotic AI system automated discovery of optimum cell culture protocol, a most experience-dependent process in regenerative medicine.