Molecular architecture of the IFT-A complex

Latest research

1. 1. Structural Biology and Molecular Biophysics

   Sublytic gasdermin-D pores captured in atomistic molecular simulations

   Stefan L Schaefer, Gerhard Hummer

   Molecular dynamics simulations reveal the formation of membrane pores by gasdermin-D, the ultimate effector of pyroptotic cell death in inflammation and infection.
2. 1. Biochemistry and Chemical Biology
   2. Neuroscience

   Chronic Ca²⁺ imaging of cortical neurons with long-term expression of GCaMP-X

   Jinli Geng, Yingjun Tang ... Xiaodong Liu

   Focusing on calcium oscillations in relation to neuronal morphology both in vitro and in vivo, rationally designed GCaMP-X provides a simple solution to neuronal toxicity of conventional GCaMP in imaging applications involving prolonged and/or strong expression of calcium probes.
3. 1. Neuroscience

   Dorsal striatum coding for the timely execution of action sequences

   Maria Cecilia Martinez, Camila Lidia Zold ... Mariano Andrés Belluscio

   In adolescent rats, whose actions are more impulsive, neuronal striatal activity that precedes self-initiated action sequences has a steeper modulation by waiting time compared to the modulation found in adults.
4. 1. Immunology and Inflammation

   Cell-intrinsic ceramides determine T cell function during melanoma progression

   Matthias Hose, Anne Günther ... Wiebke Hansen

   Cell-intrinsic ceramide concentrations are involved in T cell differentiation and function.
5. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Metrics of high cofluctuation and entropy to describe control of cardiac function in the stellate ganglion

   Nil Z Gurel, Koustubh B Sudarshan ... Olujimi A Ajijola
6. 1. Cancer Biology
   2. Medicine

   Non-coding RNAs in drug and radiation resistance of bone and soft-tissue sarcoma: a systematic review

   Huan-Huan Chen, Tie-Ning Zhang ... Tao Zhang

   Non-coding RNAs appear to be good candidates as biomarkers for predicting treatment response and therapeutics for sarcoma, their differential expression across tissues complicates their application.
7. 1. Computational and Systems Biology
   2. Neuroscience

   Self-configuring feedback loops for sensorimotor control

   Sergio Oscar Verduzco-Flores, Erik De Schutter

   Learning to reach in the sensorimotor loop, and the required neural dynamics, can be potentially explained by simple principles.
8. 1. Neuroscience

   Fast rule switching and slow rule updating in a perceptual categorization task

   Flora Bouchacourt, Sina Tafazoli ... Nathaniel D Daw

   Flexible cognition relies on a combination of fast inferential learning and slow incremental learning.
9. 1. Neuroscience
   2. Structural Biology and Molecular Biophysics

   Reevaluation of Piezo1 as a gut RNA sensor

   Alec R Nickolls, Gabrielle S O'Brien ... Alexander T Chesler

   Piezo1 ion channels are not modulated by RNA ligands, contrary to previous findings.
10. 1. Neuroscience

    Robust group- but limited individual-level (longitudinal) reliability and insights into cross-phases response prediction of conditioned fear

    Maren Klingelhöfer-Jens, Mana R Ehlers ... Tina B Lonsdorf

    Reliability and predictability analyses beyond standard measures provide empirically based guidance regarding the design of fear conditioning tasks to assess individual differences and group-level inferences cross-sectionally and longitudinally.