Latest research

1. 1. Cancer Biology
   2. Cell Biology

   Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation

   Maxim I Maron et al.

   Biochemical, transcriptomic, and proteomic analyses reveal that protein arginine methyltransferases post-transcriptionally regulate intron detention—introns that persist in nuclear polyadenylated RNA—through methylation of RNA splicing and processing factors.
2. 1. Epidemiology and Global Health

   Social contact patterns and implications for infectious disease transmission – a systematic review and meta-analysis of contact surveys

   Andria Mousa et al.

   Differences in patterns of social contact between settings have consequences for the spread and transmission of respiratory pathogens and the effectiveness of different measures aimed at their control.
3. 1. Neuroscience

   Similar neural and perceptual masking effects of low-power optogenetic stimulation in primate V1

   Spencer Chin-Yu Chen et al.

   Simultaneous optogenetic stimulation and calcium imaging in V1 of behaving macaques reveals that low-power optostimulation can substitute a visual mask and significantly reduce perceptual and neural detection sensitivities.
4. 1. Developmental Biology
   2. Evolutionary Biology

   Cavefish cope with environmental hypoxia by developing more erythrocytes and overexpression of hypoxia-inducible genes

   Corine M van der Weele, William R Jeffery

   Astyanax mexicanus cavefish cope with hypoxic environments by expanding embryonic hematopoietic domains, increasing the capacity for erythrocyte development, and constitutive overexpression of hypoxia-inducible genes.
5. 1. Cell Biology
   2. Developmental Biology

   Autophagosomes fuse to phagosomes and facilitate the degradation of apoptotic cells in Caenorhabditis elegans

   Omar Peña-Ramos et al.

   The crosstalk between autophagy and the phagocytosis of apoptotic cells, two cellular clearance pathways, promotes the fusion of the double-membrane autophagosomes to the phagosomes and plays an important role in the degradation of engulfed apoptotic cells.
6. 1. Neuroscience

   Context-dependent relationships between locus coeruleus firing patterns and coordinated neural activity in the anterior cingulate cortex

   Siddhartha Joshi, Joshua I Gold

   Simultaneous recordings in brainstem and cortex, combined with pupillometry, show that changes in coordinated activity in anterior cingulate cortex are related to distinct patterns of pupil-linked activation of the locus coeruleus-norepinephrine system.
7. 1. Neuroscience
   2. Physics of Living Systems

   A theory of synaptic transmission

   Bin Wang, Olga K Dudko

   The analytic theory establishes the general principles of synaptic transmission, enables extraction of microscopic parameters of synaptic fusion machinery from experiments, and links molecular constituents to synaptic function.
8. 1. Evolutionary Biology

   The population genetics of collateral resistance and sensitivity

   Sarah M Ardell, Sergey Kryazhimskiy

   A theoretical model that considers the diversity of collateral effects among drug resistance mutations provides insights into the development of robust sequential antibiotic treatments.
9. 1. Developmental Biology
   2. Neuroscience

   PRC1 sustains the integrity of neural fate in the absence of PRC2 function

   Ayana Sawai et al.

   Regulation of neuronal diversity and fate through protein complexes involved in gene repression and chromatin condensation.
10. 1. Evolutionary Biology
    2. Genetics and Genomics

    Genetic basis and dual adaptive role of floral pigmentation in sunflowers

    Marco Todesco et al.

    Variation in patterns of floral UV pigmentation is controlled by a single transcription factor in sunflower and affects both pollinator attraction and responses to environmental stresses.