Latest research

1. 1. Computational and Systems Biology

   Focal seizures are organized by feedback between neural activity and ion concentration changes

   Damiano Gentiletti et al.

   Biophysically realistic computational model reveals how inhibitory interneurons initiate paroxysmal discharges and how changes in the ionic concentrations shape electrographic features of human seizures.
2. 1. Cancer Biology
   2. Cell Biology

   Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression

   Qiangqiang Liu et al.

   SIAH2 and OTUD5 orchestrate DBC1 ubiquitination and degradation under hypoxic conditions.
3. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase

   Ryo Fujisawa et al.

   UBX proteins reduce the ubiquitin threshold of mammalian p97-UFD1-NPL4.
4. 1. Developmental Biology

   Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers

   Qiyan Mao et al.

   In vitro grown human muscle fibers display remarkable self-organisation capacities at the tissue, cellular, and molecular levels that are coordinated by mechanical tension.
5. 1. Immunology and Inflammation

   Tissue-specific modifier alleles determine Mertk loss-of-function traits

   Yemsratch T Akalu et al.
6. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Transcriptional heterogeneity and cell cycle regulation as central determinants of primitive endoderm priming

   Marta Perera et al.
7. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   PH domain-mediated autoinhibition and oncogenic activation of Akt

   Hwan Bae et al.
8. 1. Cell Biology

   PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells

   Gina M LoMastro et al.
9. 1. Structural Biology and Molecular Biophysics

   Structures of topoisomerase V in complex with DNA reveal unusual DNA binding mode and novel relaxation mechanism

   Amy Osterman, Alfonso Mondragón
10. 1. Developmental Biology
    2. Genetics and Genomics

    Feedback between a retinoid-related nuclear receptor and the let-7 microRNAs controls the pace and number of molting cycles in C. elegans

    Ruhi Patel et al.

    A genetic oscillator composed of NHR-23 and let-7 family of microRNAs links the molting cycle timer and the heterochronic pathway to regulate the pace of molting in C. elegans and ensure that worms molt only four times.