Latest research

1. 1. Computational and Systems Biology
   2. Human Biology and Medicine

   Unsupervised machine learning reveals risk stratifying glioblastoma tumor cells

   Nalin Leelatian et al.

   A new automated and unsupervised algorithm, Risk Assessment Population IDentification, identifies risk-stratifying cells in single cell datasets with robust statistical and biological validation.
2. 1. Microbiology and Infectious Disease

   Structural basis for capsid recruitment and coat formation during HSV-1 nuclear egress

   Elizabeth B Draganova et al.

   Interactions were visualized between the nuclear egress complex from herpes simplex virus and a capsid protein that could promote nucleocytoplasmic translocation of the capsid in infected cells.
3. 1. Cell Biology
   2. Developmental Biology

   Caenorhabditis elegans PIEZO channel coordinates multiple reproductive tissues to govern ovulation

   Xiaofei Bai et al.

   Depletion of the mechanosensitive ion channel PEZO-1 in C. elegans disrupts the sheath and spermathecae cells to disrupt oocyte ovulation, resulting in crushed oocytes.
4. 1. Neuroscience

   Aberrant sorting of hippocampal complex pyramidal cells in type I lissencephaly alters topological innervation

   James A D'Amour et al.

   The loss of lamination in mammalian brain structures under cellular heterotopia carries with it non-uniform ramifications for the various components of the canonical CA1 microcircuitry.
5. 1. Developmental Biology

   The Wg and Dpp morphogens regulate gene expression by modulating the frequency of transcriptional bursts

   Rachael Bakker et al.

   Experimental results in Drosophila support a model in which gene expression is fundamentally controlled by morphogens tuning the same transcription parameter for genes that are expressed in highly diverse patterns.
6. 1. Cell Biology

   Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface

   Abril Angélica Escamilla-Ayala et al.

   Super-resolution microscopy sets a new strategy to comprehend the membrane organization of γ-secretase at single complex resolution identifying nanodomain associations and its diffusion in situ in the living membrane.
7. 1. Ecology
   2. Evolutionary Biology

   Eco-evolutionary dynamics of nested Darwinian populations and the emergence of community-level heredity

   Guilhem Doulcier et al.
8. 1. Epidemiology and Global Health
   2. Microbiology and Infectious Disease

   Earliest infections predict the age distribution of seasonal influenza A cases

   Philip Arevalo et al.
9. 1. Epidemiology and Global Health

   Trends in snakebite deaths in India from 2000 to 2019 in a nationally representative mortality study

   Wilson Suraweera et al.

   Prevention and antivenom treatment could reduce snakebite deaths, which killed 1.2 million Indians from 2000-2019, about 70% of which occurred in eight states, and half during four rainy months.
10. 1. Developmental Biology

    Muscle-derived Myoglianin regulates Drosophila imaginal disc growth

    Ambuj Upadhyay et al.