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Highlights

  • Getting to grips with touch

    Experiments on duck cells reveal how forces on the skin are converted into electrical signals in sensory neurons. Photo: Bagriantsev Laboratory

    Luke H Ziolkowski, Elena O Gracheva, Sviatoslav N Bagriantsev
    Short Report Updated

  • Brain injury and aging

    Studies of transcription reveal how traumatic brain injury and aging influence cell composition and gene expression in the meninges.

    Ashley C Bolte, Daniel A Shapiro ... John R Lukens
    Tools and Resources

  • eLife Board of Directors

    eLife is pleased to welcome four new members to its Board of Directors, which helps to direct the organization in its mission to transform research communication.

    Inside eLife

Latest research

    1. Structural Biology and Molecular Biophysics

    A mechanism of uncompetitive inhibition of the serotonin transporter

    Shreyas Bhat, Ali El-Kasaby ... Walter Sandtner
    Biochemical and electrophysiological approaches show that the amphetamine derivative ECSI#6 is an uncompetitive inhibitor of the serotonin transporter and thus the first ever characterized ligand of a solute carrier of this type.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanism of Ca2+ transport by ferroportin

    Jiemin Shen, Azaan Saalim Wilbon ... Yaping Pan
    Cryo-EM structure and functional analyses show that human iron exporter ferroportin (Fpn) can bind and transport calcium ions and the transport activity is reduced when the concentration of ferrous ions is high.
    1. Medicine

    Phenome-wide Mendelian randomisation analysis identifies causal factors for age-related macular degeneration

    Thomas H Julian, Johnathan Cooper-Knock ... Panagiotis I Sergouniotis
    A phenome-wide Mendelian randomisation analysis revealed a causal link between age-related macular degeneration and a number of lipid, complement, immune cell, and serum protein traits, highlighting potential treatment targets.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains

    Artur Meller, Jeffrey M. Lotthammer ... Gregory R Bowman
    1. Neuroscience

    Internal neural states influence the short-term effect of monocular deprivation in human adults.

    Yiya Chen, Yige Gao ... Jiawei Zhou
    1. Neuroscience
    2. Physics of Living Systems

    Scale-free behavioral dynamics directly linked with scale-free cortical dynamics

    Sabrina A Jones, Jacob H Barfield ... Woodrow L Shew
    1. Cell Biology
    2. Medicine

    Efficacy and safety of metabolic interventions for the treatment of severe COVID-19: in vitro, observational, and non-randomized open label interventional study

    Avner Ehrlich, Konstantinos Ioannidis ... Yaakov Nahmias
    1. Immunology and Inflammation

    Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2

    Oksana Tsyklauri, Tereza Chadimova ... Ondrej Stepanek
    1. Evolutionary Biology

    Mammalian forelimb evolution is driven by uneven proximal-to-distal morphological diversity

    Priscila S Rothier, Anne-Claire Fabre ... Anthony Herrel
    1. Neuroscience

    Signal denoising through topographic modularity of neural circuits

    Barna Zajzon, David Dahmen ... Renato Duarte
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Magazine

    1. Neuroscience

    Entorhinal Cortex: Use it or lose it

    Ohad Rechnitz, Dori Derdikman
    1. Neuroscience

    Motion Processing: How the brain stays in sync with the real world

    Damian Koevoet, Andre Sahakian, Samson Chota
    1. Immunology and Inflammation

    T Cells: Ready and waiting to go

    Laura Rivino, Linda Wooldridge
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolution: How (some) mammals lost their hair

    Matthew D Dean
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Osteoporosis: Finding the genes for fragile bones

    Erika Kague
    1. Genetics and Genomics

    Model Organisms: The holy grail of longevity research

    Ajay S Mathuru
    1. Developmental Biology
    2. Medicine

    Meta-Research: The need for more research into reproductive health and disease

    Natalie D Mercuri, Brian J Cox
  8. See more Magazine articles

Research categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
  16. Plant Biology
  17. Stem Cells and Regenerative Medicine
  18. Structural Biology and Molecular Biophysics
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