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Latest research

    1. Cell Biology

    Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore

    Evgeniya Trofimenko et al.
    Cationic cell-penetrating peptides (CPPs) enter cells through ~2 (–5)-nm-wide water pores induced by the strong negative plasma membrane potential that CPPs and the activity of potassium channels generate.
    1. Neuroscience

    Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice

    Julia A Kuhn et al.
    Intrathecal injection of CSF1 induces greater upregulation of spinal microglial genes in male versus female mice, however, Treg depletion enhances microglial activation and restores pain hypersensitivity in the female mice.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Phases of cortical actomyosin dynamics coupled to the neuroblast polarity cycle

    Chet Huan Oon, Kenneth E Prehoda
    Oon and Prehoda discover cortical actomyosin dynamics that polarize asymmetrically dividing neural stem cells.
    1. Neuroscience

    A 3D adult zebrafish brain atlas (AZBA) for the digital age

    Justin W Kenney et al.
    A new tool for three-dimensional exploration of adult zebrafish neuroanatomy.
    1. Microbiology and Infectious Disease

    The Lyme disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector

    Xiaotian Tang et al.
    A new tick metabolic pathway that is connected to the survival of the Lyme disease spirochete was identified, which may lead to new ways to interfere with the spirochete life cycle.
    1. Immunology and Inflammation

    Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model

    Takemichi Fukasawa et al.
    Single-cell analysis revealed that autoantigen-reactive B cells changed the type of cytokines they produced from anti-inflammatory IL-10 and IL-35 to pro-inflammatory IL-6 and IL-23 as affinity to autoantigen increased.
    1. Immunology and Inflammation

    Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation

    Drew Wilfahrt et al.
    Histone deacetylase 3 is required for CD4+ T cells to downregulate two cholesterol efflux transport proteins, ABCA1 and ABCG1, for successful proliferation after antigenic stimulation.