Latest research

1. 1. Structural Biology and Molecular Biophysics

   Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain

   Zhicheng Zuo et al.

   The catalytic activation of the Cas9 HNH domain involves a unique conformational change in the ββα-metal motif that is collectively driven by the interactions with the metal ions and DNA.
2. 1. Cell Biology

   Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk

   Olga Afonso et al.

   Quantitative live-cell microscopy and molecular perturbations in Drosophila and human cells reveal a crosstalk between molecular 'rulers' (Aurora B) and 'clocks' (Cdk1) that coordinates mitotic exit in space and time.
3. 1. Cancer Biology

   Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice

   Shun Kishimoto et al.

   Using noise suppression, real-time imaging of glucose metabolism is possible by 13C MRI and reveals previously undetected metabolic differences within tumors.
4. 1. Evolutionary Biology
   2. Genetics and Genomics

   A de novo evolved gene in the house mouse regulates female pregnancy cycles

   Chen Xie et al.
5. 1. Evolutionary Biology
   2. Genetics and Genomics

   Sex-specific transcriptomic responses to changes in the nutritional environment

   M Florencia Camus et al.
6. 1. Biochemistry and Chemical Biology
   2. Plant Biology

   Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis

   Jinsheng Zhu et al.
7. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B

   Timo Vögtle et al.
8. 1. Structural Biology and Molecular Biophysics

   Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex

   Emiko Uchikawa et al.
9. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   A single K⁺-binding site in the crystal structure of the gastric proton pump

   Kenta Yamamoto et al.

   Crystal structures provide structural rationales for the transport stoichiometry of the gastric proton pump, which suffices the energy requirement for the generation of a million-fold proton gradient across the membrane.
10. 1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Distinct mechanisms of microRNA sorting into cancer cell-derived extracellular vesicle subtypes

    Morayma M Temoche-Diaz et al.