Latest research

1. 1. Chromosomes and Gene Expression

   Dual control of NAD⁺ synthesis by purine metabolites in yeast

   Benoît Pinson et al.

   Two distinct processes drive coordinated synthesis of purine and pyridine (NAD⁺) nucleotides in response to AICAR derivatives and ATP.
2. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Nerfin-1 represses transcriptional output of Hippo signaling in cell competition

   Pengfei Guo et al.

   The zinc finger protein Nerfin-1 represses the transcriptional output of Hippo signaling in cell competition by binding to the TEA DNA-binding domain of Scalloped.
3. 1. Neuroscience

   Cortico-hippocampal network connections support the multidimensional quality of episodic memory

   Rose A Cooper, Maureen Ritchey
4. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Conformational and dynamical plasticity in substrate-binding proteins underlies selective transport in ABC importers

   Marijn de Boer et al.
5. 1. Neuroscience

   One bout of neonatal inflammation impairs adult respiratory motor plasticity in male and female rats

   Austin D Hocker et al.
6. 1. Genetics and Genomics

   Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage

   Angela Schulz et al.
7. 1. Neuroscience

   Neuronal reactivation during post-learning sleep consolidates long-term memory in Drosophila

   Ugur Dag et al.

   Consolidation of long-term courtship memory in Drosophila is mediated by a novel class of sleep promoting neurons that reactivates dopaminergic neurons engaged earlier in memory acquisition during post-learning sleep.
8. 1. Cancer Biology

   Different genetic mechanisms mediate spontaneous versus UVR-induced malignant melanoma

   Blake Ferguson et al.

   Genetic variation determines whether or not UV exposure accelerates melanoma development.
9. 1. Human Biology and Medicine
   2. Structural Biology and Molecular Biophysics

   A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice

   Wenli Dai et al.

   TBX5-loss associated cardiomyocyte ectopy and atrial fibrillation is prevented by augmentation of SERCA2 activity, establishing a mechanism underlying the genetic basis for a Ca²⁺-dependent pathway for AF risk.
10. 1. Evolutionary Biology
    2. Genetics and Genomics

    Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies

    Mashaal Sohail et al.

    Polygenic selection signals in humans estimated from previously existing GWAS should be viewed with caution due to concerns about residual population stratification.