Targeting a methyltransferase

Latest research

1. 1. Immunology and Inflammation

   B cell expression of the enzyme PexRAP, an intermediary in ether lipid biosynthesis, promotes antibody responses and germinal center size

   Sung Hoon Cho, Marissa A Jones ... Mark R Boothby
2. 1. Neuroscience

   Input-specific gating of NMDA amplification via HCN channels in mouse L2/3 pyramidal neurons

   Viktor János Oláh, Jing Wu ... Matthew JM Rowan
3. 1. Epidemiology and Global Health

   Serum metabolome indicators of early childhood development in the Brazilian National Survey on Child Nutrition (ENANI-2019)

   Marina Padilha, Victor Nahuel Keller ... Gilberto Kac
4. 1. Cell Biology

   Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis

   Joan Chang, Adam Pickard ... Karl E Kadler

   Secretion and fibrillogenesis of collagen-I are separately controlled molecular pathways in the fibroblast, where surprisingly endocytic recycling is required for fibril formation and is increased in fibrotic fibroblasts.
5. 1. Neuroscience

   Complementary cognitive roles for D2-MSNs and D1-MSNs during interval timing

   Robert A Bruce, Matthew Weber ... Kumar Narayanan

   Dorsomedial D2-MSNs and D1-MSNs exhibit opposing dynamics during interval timing, however disrupting either MSN type produces similar effects on behavior, highlighting the complementary roles of striatal pathways in cognitive operations.
6. 1. Epidemiology and Global Health

   Leveraging mobility data to analyze persistent SARS-CoV-2 mutations and inform targeted genomic surveillance

   Riccardo Spott, Mathias W Pletz ... Christian Brandt

   Integrating mobile service and fine-granular sample data enhances SARS-CoV-2 genomic surveillance, improving variant tracking, optimizing efficiency, and guiding targeted sampling strategies.
7. 1. Genetics and Genomics

   3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity

   Khanh B Trang, Matthew C Pahl ... Struan FA Grant

   Integration of GWAS summary statistics with extensive 3D genomic datasets generated in a myriad of different cell types provides genomic insights into pediatric obesity pathogenesis.
8. 1. Neuroscience

   Statistical learning beyond words in human neonates

   Ana Fló, Lucas Benjamin ... Ghislaine Dehaene-Lambertz
9. 1. Microbiology and Infectious Disease
   2. Epidemiology and Global Health

   Persistent cross-species transmission systems dominate Shiga toxin-producing Escherichia coli O157:H7 epidemiology in a high incidence region: a genomic epidemiology study

   Gillian AM Tarr, Linda Chui ... Tim A McAllister
10. 1. Neuroscience

    Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes

    François Kroll, Joshua Donnelly ... Jason Rihel