Latest research

1. 1. Chromosomes and Gene Expression

   Sustained TNF-α stimulation leads to transcriptional memory that greatly enhances signal sensitivity and robustness

   Zuodong Zhao et al.

   Sustained TNF-α induction consolidates transcriptional memory for faster, stronger, and more sensitive subsequent induction in an active DNA demethylation-dependent manner for memory genes including CALCB, a therapeutic target for migraine.
2. 1. Ecology
   2. Evolutionary Biology

   Sexual dimorphism in trait variability and its eco-evolutionary and statistical implications

   Susanne RK Zajitschek et al.

   Sex differences in trait variability imply that both sexes should be included in biomedical trials, using sex-specific statistical power calculations.
3. 1. Neuroscience

   SpikeInterface, a unified framework for spike sorting

   Alessio P Buccino et al.

   SpikeInterface is an open-source software framework designed to build full analysis pipelines for extracellular recordings in a seamless and reproducible way.
4. 1. Cell Biology
   2. Physics of Living Systems

   A physical mechanism of TANGO1-mediated bulky cargo export

   Ishier Raote et al.

   TANGO1 functions as a linactant filament to stabilize shallow COPII-coated buds, and after which membrane tension regulation, possibly mediated by TANGO1-controlled membrane fusion, facilitates bud elongation for procollagen export.
5. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation

   Xiaowei Hou et al.
6. 1. Evolutionary Biology
   2. Physics of Living Systems

   Hydrodynamics of sponge pumps and evolution of the sponge body plan

   Seyed Saeed Asadzadeh et al.
7. 1. Evolutionary Biology
   2. Genetics and Genomics

   Bedrock radioactivity influences the rate and spectrum of mutation

   Nathanaëlle Saclier et al.
8. 1. Computational and Systems Biology

   Evolved bacterial resistance against fluoropyrimidines can lower chemotherapy impact in the Caenorhabditis elegans host

   Brittany Rosener et al.
9. 1. Chromosomes and Gene Expression

   EHMT2 epigenetically suppresses Wnt signaling and is a potential target in embryonal rhabdomyosarcoma

   Ananya Pal et al.
10. 1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11

    Iga Kucharska et al.

    A comprehensive structural analysis of inhibitory murine antibody 3D11 binding to Plasmodium berghei circumsporozoite protein reveals common mechanisms of antibody evolution in mammals against Plasmodium parasites.