eLife is an open-access journal that publishes promising research in the life and biomedical sciences

Latest research

    1. Developmental Biology and Stem Cells

    Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1

    David Kimelman et al.
    Analysis of a double mutant in the Hippo pathway transcription factors Yap1 and Wwtr1 reveals novel roles for these factors in posterior body formation and epidermal morphogenesis in the vertebrate embryo.
    1. Neuroscience

    A postsynaptic PI3K-cII dependent signaling controller for presynaptic homeostatic plasticity

    Anna G Hauswirth et al.
    A screen encompassing all kinases and phosphatases reveals that PI3K-cII, PI3K-cIII and Rab11-dependent recycling endosomes comprise a novel, postsynaptic 'signaling controller' that is part of an integrated, trans-synaptic signaling system necessary for presynaptic homeostatic plasticity.
    1. Neuroscience

    Output variability across animals and levels in a motor system

    Angela Wenning et al.
    Population output variability in a motor control system varies across levels (CPG, motor neurons, muscles) and can be ascribed to life history differences among animals and in some cases to differences between bilaterally homologous elements.
    1. Cancer Biology
    2. Human Biology and Medicine

    Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells

    Krishna Kalyan Kolluri et al.
    Loss of BAP1 function is associated with increased sensitivity to TRAIL and other death receptor agonists in malignant mesothelioma, where this is a frequent event, with immediate and actionable therapeutic implications.
    1. Cell Biology

    Heat stress promotes longevity in budding yeast by relaxing the confinement of age-promoting factors in the mother cell

    Sandro Baldi et al.
    To promote longevity under heat stress shares yeast aging factors with progeny through a down-regulation of the diffusion barrier in the membranes between the mitotic cells.
    1. Computational and Systems Biology
    2. Genomics and Evolutionary Biology

    Intrinsic adaptive value and early fate of gene duplication revealed by a bottom-up approach

    Guillermo Rodrigo, Mario A Fares
    Gene duplication is a useful strategy to reduce intrinsic noise in gene expression, which can provide a selective advantage in scenarios of cost-benefit analysis of expression.