eLife works to improve research communication through open science and open technology innovation

Latest research

    1. Developmental Biology
    2. Plant Biology

    Genetic analysis of the Arabidopsis TIR1/AFB auxin receptors reveals both overlapping and specialized functions

    Michael J Prigge et al.
    Genetic analyses reveal that the TIR1/AFB auxin receptors have broadly overlapping functions throughout plant development, but that the AFB1 receptor has a specialized role in a rapid auxin response.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Plasmodium-infected erythrocytes induce secretion of IGFBP7 to form type II rosettes and escape phagocytosis

    Wenn-Chyau Lee et al.
    Plasmodium parasites use host-derived factors to form more rosettes and hamper phagocytosis, representing a new escape mechanism for the malaria parasites.
    1. Chromosomes and Gene Expression

    Integrated analysis of H2A.Z isoforms function reveals a complex interplay in gene regulation

    Assala Lamaa et al.
    The two H2A.Z isoforms have specific interactors which mediate their differential effects on gene expression.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A tryparedoxin-coupled biosensor reveals a mitochondrial trypanothione metabolism in trypanosomes

    Samantha Ebersoll et al.
    African trypanosomes have a trypanothione-based mitochondrial thiol redox metabolism.
    1. Neuroscience

    Medial entorhinal cortex activates in a traveling wave in the rat

    J Jesús Hernández-Pérez et al.
    The existence of traveling waves in the medial entorhinal cortex, like those observed in the hippocampus, supports the hypothesis that traveling waves coordinate the activity of anatomically distributed circuits.
    1. Developmental Biology

    A phenotypic screening platform utilising human spermatozoa identifies compounds with contraceptive activity

    Franz S Gruber et al.
    A high-throughput phenotypic human sperm screening platform was developed which allows for major drug discovery programmes for male contraception.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Receptor-based mechanism of relative sensing and cell memory in mammalian signaling networks

    Eugenia Lyashenko et al.
    Preferential endocytosis of activated receptors allows cells to memorize their past and perform relative sensing.