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Latest research

    1. Neuroscience

    Structure and function of axo-axonic inhibition

    Casey M Schneider-Mizell et al.
    Electron microcopy-based connectomics, in vivo functional imaging, and biophysical modeling reveal that mouse visual cortex chandelier cells, a type of GABAergic interneuron, are driven by arousal and distribute their synapses according to the individual properties of target cells.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Determinants shaping the nanoscale architecture of the mouse rod outer segment

    Matthias Pöge et al.
    Cryo-electron tomography of close-to-native rod outer segments resolves connectors between disks and a scaffold at the disk rim enforcing the high membrane curvature of the unique long-range organization in these rhodopsin-rich light-sensitive subcellular organelles.
    1. Neuroscience

    Dopamine enhances model-free credit assignment through boosting of retrospective model-based inference

    Lorenz Deserno et al.
    Cooperation between model-free and model-based control systems is boosted by enhancing dopamine levels.
    1. Developmental Biology
    2. Neuroscience

    insomniac links the development and function of a sleep-regulatory circuit

    Qiuling Li et al.
    Spatiotemporal manipulations of insomniac reveal that this gene regulates the birth and development of sleep-regulatory neurons, enabling their proper function in adulthood.
    1. Physics of Living Systems

    Strong confinement of active microalgae leads to inversion of vortex flow and enhanced mixing

    Debasmita Mondal et al.
    Coupling between cell motility and strong confinement alters the force generators that cause flow fields to change their handedness and lead to enhanced mixing.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1

    Andrea Loreto et al.
    The identification of the mechanism of action of vacor, an environmental neurotoxin which causes neurodegeneration by activating the pro-degenerative enzyme SARM1, raises important questions on SARM1 as a mediator of environmental neurotoxicity and has implications for drug discovery.