Latest research

1. 1. Genetics and Genomics
   2. Evolutionary Biology
   3. Human Biology and Medicine

   Determining the genetic basis of anthracycline-cardiotoxicity by molecular response QTL mapping in induced cardiomyocytes

   David A Knowles et al.

   Genetic variants that modulate transcriptomic response to doxorubicin in human iPSC-derived cardiomyocytes are predictive of cardiac damage and in vivo sensitivity to anthracycline cardiotoxicity.
2. 1. Biochemistry and Chemical Biology

   Ribozyme-catalysed RNA synthesis using triplet building blocks

   James Attwater et al.

   Adopting RNA trinucleotides as substrates, ribozymes can catalyse the copying of structured RNA sequences, allowing self-synthesis by part of a newly evolved symbiotic ribozyme pair.
3. 1. Evolutionary Biology
   2. Neuroscience

   A cerebellar substrate for cognition evolved multiple times independently in mammals

   Jeroen B Smaers et al.

   Multiple independent directional selection events on a neural substrate that underpins domain-general associative abilities partly explains independent occurrences of complex behavior in different lineages of mammals.
4. 1. Biochemistry and Chemical Biology

   Group II intron inhibits conjugative relaxase expression in bacteria by mRNA targeting

   Guosheng Qu et al.

   Group II introns can target mRNA, causing inhibition of gene expression, as a potential driver for evolution to the spliceosome.
5. 1. Neuroscience

   PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse

   Rachel A Ross et al.
6. 1. Developmental Biology and Stem Cells

   Adult zebrafish Langerhans cells arise from hematopoietic stem/progenitor cells

   Sicong He et al.
7. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Shearing in flow environment promotes evolution of social behavior in microbial populations

   Gurdip Uppal, Dervis Can Vural

   Shearing in fluid flow induces or enhances budding dispersal in microbial populations, resulting in stronger cooperative behavior.
8. 1. Cell Biology
   2. Neuroscience

   Tenectin recruits integrin to stabilize bouton architecture and regulate vesicle release at the Drosophila neuromuscular junction

   Qi Wang et al.
9. 1. Neuroscience

   Principal cells of the brainstem's interaural sound level detector are temporal differentiators rather than integrators

   Tom P Franken et al.
10. 1. Cancer Biology
    2. Structural Biology and Molecular Biophysics

    Dynamics of human protein kinase Aurora A linked to drug selectivity

    Warintra Pitsawong et al.