eLife is an open-access journal that publishes promising research in the life and biomedical sciences

Latest research

    1. Neuroscience

    Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of DAPK1

    Jamie McQueen et al.
    Short Report
    Available as authors' accepted manuscript pdf
    1. Cancer Biology
    2. Computational and Systems Biology

    Defining the biological basis of radiomic phenotypes in lung cancer

    Patrick Grossmann et al.
    1. Neuroscience

    Ionic mechanisms underlying history-dependence of conduction delay in an unmyelinated axon

    Yang Zhang et al.
    Conduction velocity of action potentials in unmyelinated axons depends ultimately on the gating variables of the fast voltage-gated sodium current and can be predicted from the action potential peak and trough voltages.
    Research Article Updated
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biophysics and Structural Biology
    2. Computational and Systems Biology

    Modeling Hsp70/Hsp40 interaction by multi-scale molecular simulations and coevolutionary sequence analysis

    Duccio Malinverni et al.
    Integration of complementary computational approaches reveals an evolutionarily conserved interaction interface between molecular chaperones Hsp70 and Hsp40, rationalizing previous observations.
    Research Article Updated
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Genomics and Evolutionary Biology

    Repeated losses of PRDM9-directed recombination despite the conservation of PRDM9 across vertebrates

    Zachary Baker et al.
    PRDM9 is widely conserved across vertebrates yet has been lost numerous times, as has its role in directing meiotic recombination.
    Research Article Updated
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    Bmal1 function in skeletal muscle regulates sleep

    J Christopher Ehlen et al.
    Short Report
    Available as authors' accepted manuscript pdf
    1. Plant Biology

    Lipid transfer from plants to arbuscular mycorrhiza fungi

    Andreas Keymer et al.