Evolution and infertility

Latest research

1. 1. Neuroscience

   Aminergic and peptidergic modulation of Insulin-Producing Cells in Drosophila

   Martina Held, Rituja S Bisen ... Jan M Ache
2. 1. Plant Biology

   Arabidopsis SDG proteins mediate Polycomb removal and transcription-coupled H3K36 methylation for gene activation

   Nobutoshi Yamaguchi, Wang Yicong ... Toshiro Ito
3. 1. Computational and Systems Biology

   A three filament mechanistic model of musculotendon force and impedance

   Matthew Millard, David W Franklin, Walter Herzog

   Benchmark simulations show that the VEXAT muscle model is more accurate than a Hill-type muscle model at mimicking the response of biological muscle to length changes great and small.
4. 1. Biochemistry and Chemical Biology

   Coordinated regulation of chemotaxis and resistance to copper by CsoR in Pseudomonas putida

   Meina He, Yongxin Tao ... Wenli Chen
5. 1. Developmental Biology

   BCAS2 promotes primitive hematopoiesis by sequestering β-catenin within the nucleus

   Guozhu Ning, Yu Lin ... Qiang Wang
6. 1. Developmental Biology
   2. Genetics and Genomics

   Integration of ATAC and RNA-sequencing identifies chromatin and transcriptomic signatures in classical and non-classical zebrafish osteoblasts and indicates mechanisms of entpd5a regulation

   Kleio Petratou, Martin Stehling ... Stefan Schulte-Merker
7. 1. Cell Biology
   2. Neuroscience

   Iron-sulfur cluster loss in mitochondrial CISD1 mediates PINK1 loss-of-function phenotypes

   Sara Bitar, Timo Baumann ... Axel Methner

   PINK1 deficiency in Parkinson's disease models causes toxic oxidized and iron-depleted CISD1 yet CISD1 removal benefits PINK1 mutant Drosophila indicating its potential as a therapeutic target for mitochondrial dysfunction and neurodegeneration.
8. 1. Structural Biology and Molecular Biophysics

   Membrane curvature sensing and symmetry breaking of the M2 proton channel from Influenza A

   James Lincoff, Cole VM Helsell ... Michael Grabe

   Using a combination of all-atom molecular simulation and continuum membrane mechanics, M2 channels from influenza are shown to be stabilized in negative Gaussian curvature regions, such as the neck of budding viral particles, only in C2-symmetric conformations.
9. 1. Developmental Biology

   SRSF2 is a key player in orchestrating the directional migration and differentiation of MyoD progenitors during skeletal muscle development

   Rula Sha, Ruochen Guo ... Ying Feng

   Genetic mouse models combined with single-cell RNA sequencing reveal the essential role of SRSF2 in directing MyoD progenitors to distinct skeletal muscle domains and controlling their differentiation through the regulation of targeted genes and alternative splicing during skeletal muscle development.
10. 1. Immunology and Inflammation

    Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain

    Eva M García-Cuesta, Pablo Martínez ... Mario Mellado

    In silico modeling identify allosteric CXCR4 modulators that block receptor nanoclustering and chemoattractant sensing without affecting other CXCL12-mediated functions, and reduce tumorigenesis and metastasis in a zebrafish model.