Latest research

1. 1. Neuroscience

   Structural and functional properties of a probabilistic model of neuronal connectivity in a simple locomotor network

   Andrea Ferrario et al.

   A new probabilistic model of connectivity reveals the structural and functional properties of the neural networks controlling locomotion in many individual tadpoles.
2. 1. Genomics and Evolutionary Biology
   2. Microbiology and Infectious Disease

   Mapping mutational effects along the evolutionary landscape of HIV envelope

   Hugh K Haddox et al.

   Deep mutational scanning of Env proteins from two transmitted-founder strains of HIV shows how the accessible evolutionary space changes as the virus evolves.
3. 1. Neuroscience

   Drosophila mushroom bodies integrate hunger and satiety signals to control innate food-seeking behavior

   Chang-Hui Tsao et al.

   Mushroom bodies are a hunger and satiety integrative center that controls food-seeking behavior in Drosophila..
4. 1. Structural Biology and Molecular Biophysics

   Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme

   Zhening Zhang et al.

   Integrative structural analyses of human insulin degradingenzyme (IDE) reveal how IDE selectively degrades peptides that form toxicaggregates, which guides IDE-based therapeutic innovations to treat diabetesand Alzheimer's disease.
5. 1. Neuroscience

   Oxytocin functions as a spatiotemporal filter for excitatory synaptic inputs to VTA dopamine neurons

   Lei Xiao et al.

   Oxytocin, a peptide linked to the processing of socially meaningful stimuli, modulates excitatory synaptic transmission in dopaminergic neurons of ventral tegmental area via retrograde endocannabinoid signaling, acting as a pathway-specific temporal filter for synaptic inputs.
6. 1. Neuroscience

   Embryonic and postnatal neurogenesis produce functionally distinct subclasses of dopaminergic neuron

   Elisa Galliano et al.
7. 1. Cell Biology

   Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

   Gian-Luca McLelland et al.
8. 1. Neuroscience

   Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum

   Tim James Viney et al.

   GABAergic parvalbumin-expressing 'orchid cells' of the medial septum selectively target GABAergic neurons in connected extra-hippocampal areas of the mouse, providing rhythmically bursting inhibitory input at the peak of hippocampal 5-12 Hz theta oscillatory cycles.
9. 1. Developmental Biology and Stem Cells
   2. Neuroscience

   Directional selectivity of afferent neurons in zebrafish neuromasts is regulated by Emx2 in presynaptic hair cells

   Young Rae Ji et al.
10. 1. Computational and Systems Biology

    HIF-2α is essential for carotid body development and function

    David Macias et al.