Latest research

1. 1. Cancer Biology

   Replication Study: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

   Xiaochuan Shan et al

   Editors' Summary: This Replication Study has reproduced important parts of the original paper.
2. 1. Biochemistry
   2. Cell Biology

   Affimers proteins are versatile and renewable affinity reagents

   Christian Tiede et al.

   The Affimer technology represents renewable binding reagents for molecular biology, which provides research scientists and industry with an alternative to the recently criticised use of animal-produced antibodies.
3. 1. Biochemistry
   2. Developmental Biology and Stem Cells

   Poly(A) tail length regulates PABPC1 expression to tune translation in the heart

   Sandip Chorghade et al

   A poly(A) tail-based regulatory mechanism dynamically controls PABPC1 protein synthesis in cardiomyocytes and thereby titrates cellular translation in response to developmental and hypertrophic cues.
4. 1. Biochemistry
   2. Cancer Biology

   Replication Study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

   Megan Reed Showalter et al.

   Editors' Summary: This Replication Study has reproduced important parts of the original paper.
5. 1. Computational and Systems Biology
   2. Neuroscience

   Olfactory receptor neurons use gain control and complementary kinetics to encode intermittent odorant stimuli

   Srinivas Gorur-Shandilya et al.
6. 1. Biophysics and Structural Biology

   Structure and in situ organisation of the Pyrococcus furiosus archaellum machinery

   Bertram Daum et al.
7. 1. Cell Biology
   2. Developmental Biology and Stem Cells

   Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2

   Pierluigi Scerbo et al.

   Degradation and asymmetric inheritance during cell division of a core pluripotency regulator contributes to lineage commitment in the early Xenopus embryo.
8. 1. Genomics and Evolutionary Biology
   2. Microbiology and Infectious Disease

   Parallel evolution of influenza across multiple spatiotemporal scales

   Katherine S Xue et al

   Influenza evolution within infected hosts recapitulates many evolutionary dynamics observed at the global scale.
9. 1. Microbiology and Infectious Disease

   Cryo-electron tomography reveals novel features of a viral RNA replication compartment

   Kenneth J Ertel et al.
10. 1. Microbiology and Infectious Disease

    Rv3723/LucA coordinates fatty acid and cholesterol uptake in Mycobacterium tuberculosis

    Evgeniya V Nazarova et al

    The integral membrane protein LucA facilitates fatty acid and cholesterol uptake into Mycobacterium tuberculosis by stabilizing the Mce1 and Mce4 transporters, respectively, and Mce1 functions as a fatty acid transporter in Mycobacterium tuberculosis.