Latest research

1. 1. Neuroscience

   Emergence of visually-evoked reward expectation signals in dopamine neurons via the superior colliculus in V1 lesioned monkeys

   Norihiro Takakuwa et al.

   The subcortical visual pathway through the midbrain superior colliculus is responsible for visually evoked Pavlovian conditioning and dopamine neuron responses with predicted value in monkeys, which remained after lesioning V1.
2. 1. Neuroscience

   LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent

   Daniela Puzzo et al.

   Oligomeric Amyloid-β and Tau, two proteins involved in Alzheimer's disease pathogenesis, require Amyloid Precursor Protein to enter neurons and exert their detrimental effect on synaptic plasticity and memory.
3. 1. Genes and Chromosomes

   Evidence that Mediator is essential for Pol II transcription, but is not a required component of the preinitiation complex in vivo

   Natalia Petrenko et al.

   Mediator, a transcriptional coactivator complex, is essential for transcription but is not a required component of a functional preinitiation complex, indicating that Mediator is not equivalent to a general transcription factor.
4. 1. Neuroscience

   The heritability of multi-modal connectivity in human brain activity

   Giles L Colclough et al.
5. 1. Genes and Chromosomes

   Maturation of selected human mitochondrial tRNAs requires deadenylation

   Sarah F Pearce et al.
6. 1. Biochemistry

   Unexpected sequences and structures of mtDNA required for efficient transcription from the first heavy-strand promoter

   Akira Uchida et al.
7. 1. Human Biology and Medicine
   2. Neuroscience

   Early tissue damage and microstructural reorganization predict disease severity in experimental epilepsy

   Philipp Janz et al.

   Non-invasive imaging of hippocampal neurodegeneration and structural reorganization during epileptogenesis allows the prediction of disease severity in mesial temporal lobe epilepsy, which may facilitate the early pharmacological intervention before seizure onset.
8. 1. Genomics and Evolutionary Biology
   2. Microbiology and Infectious Disease

   Extensive horizontal gene transfer in cheese-associated bacteria

   Kevin S Bonham et al.

   The identification of horizontally transferred genes, and commonly transferred functions, can provide a window into the selective forces acting on species within an ecosystem.
9. 1. Neuroscience

   A predictive focus of gain modulation encodes target trajectories in insect vision

   Steven D Wiederman et al.

   Visual neurons in the dragonfly predict the path of a moving target, even when it is occluded or crosses from one eye to the other.
10. 1. Computational and Systems Biology
    2. Developmental Biology and Stem Cells

    Elastic force restricts the growth of the murine utricle

    Ksenia Gnedeva et al.