Highlights

  • Tsetse fly feeding adaptations

    Investigations into the biomechanics of tsetse fly blood feeding reveal that subtle anatomical adaptations enable the penetration of a diverse range of host hides.

    Stephan Löwe, Laura Hauf ... Markus Engstler
    Research Article

  • Anatomy of taste and texture

    Comprehensive ultrastructural reconstruction of the Drosophila larval pharyngeal sensory system reveals the organization and diversity of its sensory structures.

    Vincent Richter, Tilman Triphan ... Andreas S Thum
    Research Article

  • Settling down at sunset

    Transcriptomic and epigenomic profiling reveals how diminishing light induces chromatin accessibility and primes larval settlement in Amphimedon queenslandica.

    Huifang Yuan, Oceane Blard ... Sandie M Degnan
    Research Article

  • Neurosecretory connections

    Connectomic and transcriptomic analyses reveal the anatomical and functional organisation of neurosecretion in the Drosophila brain.

    Theresa H McKim, Jayati Gera ... Meet Zandawala
    Research Article

  • AI in research communication

    eLife has partnered on a number of projects harnessing AI for improving human and machine reader engagement with research.

    Inside eLife

  • Explore our new collection

    Delve into leading research on Lifestyle, Environment and Epigenetic Inheritance.

    Collection
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Cancer Biology
    2. Genetics and Genomics

    Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma

    Olivia G Waltner, April A Apfelbaum ... Scott N Furlan
    In Ewing sarcoma, a mesenchymal gene program normally repressed by the oncogenic fusion is reactivated by TGF-β signaling, and is associated with more aggressive disease.
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Massively Parallel Polyribosome Profiling Reveals Translation Defects of Human Disease-Relevant UTR Mutations

    Jia-Ying Su, Wei-Ping Li ... Chien-Ling Lin
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Dissociable effects of feature expectation on saccades and presaccadic perception

    Luan Zimmermann Bortoluzzi, Gustavo Rohenkohl
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Neuroscience

    Neural Mechanisms of Willed Attention Control

    Changhao Xiong, Yujun Chen ... Mingzhou Ding
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Molidustat targets a synthetic lethal vulnerability in APC-mutant colorectal cancer through GSTP1 and PHD2 co-inhibition

    Chiara Asselborn, Agata N Makar ... Alex von Kriegsheim
    Simultaneous loss of GSTP1 and PHD2 activity is synthetically lethal in APC-mutant colorectal cells, driving cell-cycle arrest, metabolic collapse, and apoptosis.
    1. Ecology
    2. Evolutionary Biology

    Life-history trade-offs explain local adaptation in Arabidopsis thaliana

    Benjamin Brachi, Daniele Filiault ... Magnus Nordborg
    A combination of common-garden and selection experiments identifies strong and often antagonistic selection pressures acting on different life stages, and that vary in space and time.
    1. Neuroscience

    Midbrain somatostatin-expressing cells control pain-suppression during defensive states

    Nanci Winke, Frank Aby ... Cyril Herry
    A somatostatinergic periaqueductal-to-medullary circuit controls analgesia during defensive states.
    1. Neuroscience

    Specific Sensitivity to Rare and Extreme Events: Quasi-Complete Black Swan Avoidance vs Partial Jackpot Seeking in Rat Decision-Making

    Mickaël Degoulet, Louis-Matis Willem ... Patrick A Pintus
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Genetics and Genomics

    Analysis of RNA processing directly from spatial transcriptomics data reveals previously unknown regulation

    Julia Olivieri, Julia Salzman
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Evolutionary Biology

    Super compensatory substitutions restore protein function and confer mutational robustness

    Wenhong Jiang, Hengchuang Yin ... Lucas B Carey
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
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Magazine

    1. Cell Biology
    2. Physiology

    Mechanosensory Physiology: Lymphatic vessels under pressure

    Asser F Bedair, Osama F Harraz
    1. Epidemiology and Global Health

    Science Forum: The new paradox of women’s health research

    Ursula Debarnot, Alexandre Fouré
    1. Genetics and Genomics
    2. Physiology

    Steroid Signaling: A hormonal message for a longer life

    Kyle Feola, Peter M Douglas
    1. Microbiology and Infectious Disease

    Bird Flu: The cow udder as an influenza mixing ground

    Silke Rimaux, Robert P de Vries
    1. Computational and Systems Biology

    AI in Science: The 42 problem in AI-assisted research

    Giovanni Spitale, Federico Germani
    1. Genetics and Genomics
    2. Developmental Biology
    grid of multicoloured bar graphs with vertical shaded areas in red and green highlighting specific columns

    Lifestyle, Environment and Epigenetic Inheritance: A Collection of Articles

    Edited by Wei Yan

  7. Research Culture: From East to West – an early-career researcher’s voyage across continents

    Samuel C Eziuzor
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
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  4. Chromosomes and Gene Expression
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  12. Medicine
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