Latest research

1. 1. Human Biology and Medicine
   2. Neuroscience

   Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration

   Federica Storti et al.

   Lipid efflux by the retinal pigment epithelium is crucial for proper retinal integrity and function, and its impairment may contribute to diseases like age-related macular degeneration.
2. 1. Computational and Systems Biology
   2. Stem Cells and Regenerative Medicine

   Single cell RNA-seq identifies the origins of heterogeneity in efficient cell transdifferentiation and reprogramming

   Mirko Francesconi et al.

   Variation in efficiency, speed and path during transdifferentiation and reprogramming originates from two pre-B cell subpopulations with reciprocal propensity towards each fate conversion.
3. 1. Neuroscience

   Cholinergic modulation of hippocampal calcium activity across the sleep-wake cycle

   Heng Zhou et al.

   Dynamic calcium activity in the hippocampus changes markedly across behavioral and physiological states and depends on muscarinic acetylcholine receptor activation.
4. 1. Neuroscience

   Across-species differences in pitch perception are consistent with differences in cochlear filtering

   Kerry MM Walker et al.

   Humans and other animals have different strategies for extracting the pitch of sounds, potentially driven by the species-specific frequency selectivity of the ear.
5. 1. Neuroscience

   Ventrolateral periaqueductal gray neurons prioritize threat probability over fear output

   Kristina M Wright, Michael A McDannald

   Single-unit activity in the ventrolateral periaqueductal gray, a brain region implicated in organizing fear output, is found to reflect threat probability, a more versatile threat signal.
6. 1. Developmental Biology
   2. Neuroscience

   Neurotransmitter identity is acquired in a lineage-restricted manner in the Drosophila CNS

   Haluk Lacin et al.
7. 1. Cell Biology
   2. Computational and Systems Biology

   Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

   Nona Farbehi et al.
8. 1. Stem Cells and Regenerative Medicine

   Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade

   Emily J Lodge et al.
9. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2

   Lucas Tafur et al.

   Cryo-EM structures of RNA polymerase I reveal considerable 'transformers-like' rearrangements where one subcomplex dissociates and is replaced by one domain of another subunit, possibly as an additional layer of transcriptional control.
10. 1. Cancer Biology

    Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization

    Harihar Basnet et al.