• Cylicins and male fertility

    Mutations in the genes for two cytoskeletal proteins found in sperm, Cylicin 1 and Cylicin 2, can lead to infertility in mice and humans.

    Simon Schneider, Andjela Kovacevic ... Hubert Schorle
    Research Article
  • The ins and outs of breathing

    Subpopulations of neurons in the pre-Bötzinger complex coordinate breathing with a range of physiological behaviors.

    Mariana R Melo, Alexander D Wykes ... Andrew M Allen
    Research Article Updated
  • Memory and multiple sclerosis

    A new approach to measuring visual working memory has revealed fresh insights into the origins of memory deficit in multiple sclerosis. (Photo: Pouria Motaghi CC-BY)

    Ali Motahharynia, Ahmad Pourmohammadi ... Mehdi Sanayei
    Research Article

Latest research

    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to antifungal compounds

    Vanessa Dumeaux, Samira Massahi ... Michael T Hallett
    Candida albicans cells respond in two distinct ways to fluconazole exposure where cells enter the Ribo-dominant state characterized by an upregulation of ribosomal-related proteins and processes, or cells enter the Stress-dominant state characterized by the upregulation of stress responses.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Down the Penrose stairs, or how selection for fewer recombination hotspots maintains their existence

    Zachary Baker, Molly Przeworski, Guy Sella
    Modeling the evolution of PRDM9 in light of recent results implicating the importance of PRDM9 binding symmetry suggests the advantage of new PRMD9 alleles is in limiting the number of binding sites used effectively rather than increasing net binding.
    1. Immunology and Inflammation

    Pulsed ultrasound promotes secretion of anti-inflammatory extracellular vesicles from skeletal myotubes via elevation of intracellular calcium level

    Atomu Yamaguchi, Noriaki Maeshige ... Hidemi Fujino
    Ultrasound promotes release of extracellular vesicles from cultured myotubes and elicits anti-inflammatory effects on macrophages, indicating the potential of ultrasound stimulation to muscle for anti-inflammatory purposes.
    1. Neuroscience

    Modeling apical and basal tree contribution to orientation selectivity in a mouse primary visual cortex layer 2/3 pyramidal cell

    Konstantinos-Evangelos Petousakis, Ji Young Park ... Panayiota Poirazi
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Dynamic landscape of the intracellular termini of acid-sensing ion channel 1a

    Megan M Cullinan, Robert C Klipp ... John R Bankston
    A novel FRET approach suggests that the intracellular termini of acid-sensing ion channel 1a do not form a complex at rest requiring a new hypothesis for ASIC1a involvement in stroke.
    1. Neuroscience

    Adaptive biasing of action-selective cortical build-up activity by stimulus history

    Anke Braun, Tobias H Donner
    Prior expectations about the state of the sensory environment are dynamically updated in a context-dependent manner and selectively bias the build-up of human motor cortical activity during subsequent decisions.
    1. Structural Biology and Molecular Biophysics

    Folding of prestin’s anion-binding site and the mechanism of outer hair cell electromotility

    Xiaoxuan Lin, Patrick R Haller ... Tobin R Sosnick
    Identification of Cl-induced folding advances the field’s understanding of prestin’s unique voltage-sensing mechanism and its involvement in mammalian hearing sensation.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Sustained store-operated calcium entry utilizing activated chromatin state leads to instability in iTregs

    Huiyun Lyu, Guohua Yuan ... Yan Shi
    Multidimensional study of signaling pathways and epigenomics investigates how TCR (T cell receptor) signaling and chromatin landscape interpaly and impact on Treg stability.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Apoptotic signaling clears engineered Salmonella in an organ-specific manner

    Taylor J Abele, Zachary P Billman ... Edward A Miao
    Clearance of engineered Salmonella which trigger regulated cell death is dependent upon the cellular 'bucket list,' which is determined both by cell death signaling pathway and by cell type infected.