Latest research

1. 1. Cell Biology
   2. Developmental Biology

   Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice

   Nuno Costa-Borges et al.

   Maternal spindle transfer is a feasible approach to enhance embryonic developmental of compromised oocytes, which can represent a new strategy for patients with forms of infertility refractory to current treatments.
2. 1. Neuroscience

   MeCP2 in cholinergic interneurons of nucleus accumbens regulates fear learning

   Ying Zhang et al.

   Robust fear learning deficits and decreased tonic activity of NAc cholinergic interneurons caused by depletion of MeCP2 could be attributed to an elevation in α2-containing GABA_A receptors.
3. 1. Structural Biology and Molecular Biophysics

   ER-luminal [Ca²⁺] regulation of InsP₃ receptor gating mediated by an ER-luminal peripheral Ca²⁺-binding protein

   Horia Vais et al.

   Calcium release from the endoplasmic reticulum through the IP₃ receptor ion channel is strongly regulated by a calcium-binding protein in the lumen of the endoplasmic reticulum.
4. 1. Chromosomes and Gene Expression
   2. Microbiology and Infectious Disease

   A new protocol for single-cell RNA-seq reveals stochastic gene expression during lag phase in budding yeast

   Abbas Jariani et al.

   A new high-throughput method for single-cell RNA-seq in yeast cells shows how stochastic expression of glucose-repressed genes contributes to cell-to-cell differences during adaptation to an environmental change.
5. 1. Cell Biology

   Bmal1 integrates mitochondrial metabolism and macrophage activation

   Ryan K Alexander et al.

   Macrophage Bmal1 controls the timing of the glycolytic to oxidative metabolism transition that dictates the extent of Hif-1a activation and the associated inflammatory response.
6. 1. Chromosomes and Gene Expression

   Live-cell single particle imaging reveals the role of RNA polymerase II in histone H2A.Z eviction

   Anand Ranjan et al.

   Histone variant H2A.Z is deposited near transcription start sites by the chromatin remodeler SWR1 and seems to be removed by RNA polymerase II at an early stage of transcription elongation.
7. 1. Neuroscience

   Axon-dependent expression of YAP/TAZ mediates Schwann cell remyelination but not proliferation after nerve injury

   Matthew Grove et al.

   YAP and TAZ, potent concoproteins and therapeutic targets in cancer therapy, are essential for Schwann cells to support peripheral nerve regeneration.
8. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Conformational distributions of isolated myosin motor domains encode their mechanochemical properties

   Justin R Porter et al.

   Shifts in the balance between nucleotide-favorable and nucleotide-unfavorable conformations of myosin motors encode duty ratios and ADP release rates, demonstrating the power of an ensemble perspective for uncovering sequence-function relationships.
9. 1. Developmental Biology

   Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation during axial patterning in vertebrates

   Tempei Sato et al.

   Genetic analyses reveal that the loss of Lin28a causes axial shortening with mild skeletal transformations via decreased PRC1 at Hox genes, establishing a new pathway in the “Hox code.”.
10. 1. Chromosomes and Gene Expression

    Distinct interactions of eIF4A and eIF4E with RNA helicase Ded1 stimulate translation in vivo

    Suna Gulay et al.