Latest research

1. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia

   Xuchen Hu et al.

   Macrophages release 30-nm vesicular particles enriched in accessible cholesterol during cellular locomotion, a discovery that is likely relevant to cholesterol disposal by these cells.
2. 1. Epidemiology and Global Health
   2. Structural Biology and Molecular Biophysics

   Electron cryo-microscopy of bacteriophage PR772 reveals the elusive vertex complex and the capsid architecture

   Hemanth KN Reddy et al.

   The structure and composition of the elusive vertex complex in Tectiviridae is finally revealed and the newly reported protein conformations help to maintain the capsid architecture.
3. 1. Evolutionary Biology

   Molecular function limits divergent protein evolution on planetary timescales

   Mariam M Konaté et al.

   Orthologous proteins that continuously maintain the same molecular function do not usually diverge beyond a certain level of sequence and structural similarity.
4. 1. Physics of Living Systems

   Phylodynamic theory of persistence, extinction and speciation of rapidly adapting pathogens

   Le Yan et al.
5. 1. Cell Biology
   2. Genetics and Genomics

   NHR-14 loss of function couples intestinal iron uptake with innate immunity in C. elegans through PQM-1 signaling

   Malini Rajan et al.
6. 1. Human Biology and Medicine
   2. Immunology and Inflammation

   ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in Cystic Fibrosis

   Thomas Scambler et al.
7. 1. Computational and Systems Biology
   2. Neuroscience

   Rats exhibit similar biases in foraging and intertemporal choice tasks

   Gary A Kane et al.
8. 1. Neuroscience

   Entrained neuronal activity to periodic visual stimuli in the primate striatum compared with the cerebellum

   Masashi Kameda et al.

   Neurons in the striatum exhibited periodic firing in monkeys attempting to detect omission of repetitive visual stimulus, while the phase of neuronal activity differed from that observed in the cerebellum.
9. 1. Cell Biology
   2. Plant Biology

   Two mechanisms regulate directional cell growth in Arabidopsis lateral roots

   Charlotte Kirchhelle et al.

   In lateral roots, cells employ a novel pathway to cell edges to control directional growth, which acts independently of the leading paradigm of oriented deposition of cellulose microfibrils at faces.
10. 1. Cell Biology
    2. Human Biology and Medicine

    Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity

    Kasparas Petkevicius et al.

    Obesity leads to increased phosphatidylcholine turnover in adipose tissue macrophages that makes them susceptible to saturated fatty acid-induced inflammation.