Latest research

1. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Functional reconstitution of a bacterial CO₂ concentrating mechanism in Escherichia coli

   Avi I Flamholz et al.

   A bacterial CO₂ concentrating mechanism enables Escherichia coli to fix CO₂ from ambient air into biomass.
2. 1. Neuroscience

   Forced choices reveal a trade-off between cognitive effort and physical pain

   Todd A Vogel et al.

   Cognitive effort is aversive and people will accept physical pain to avoid it, but this avoidance does not appear to share the same fundamental characteristics of pain avoidance.
3. 1. Cell Biology
   2. Microbiology and Infectious Disease

   Autophagy compensates for Lkb1 loss to maintain adult mice homeostasis and survival

   Khoosheh Khayati et al.

   Autophagy and Lkb1 work synergistically to maintain adult mouse homeostasis and survival.
4. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy

   Joseph Shaw et al.

   Exploiting virus-encoded ion channels as drug targets drove a multi-faceted approach to deriving potent small molecules targeting HCV p7, simultaneously providing new insights into its fundamental biology.
5. 1. Neuroscience

   Preserving inhibition with a disinhibitory microcircuit in the retina

   Qiang Chen et al.
6. 1. Immunology and Inflammation

   BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages

   Jie Li et al.

   Phosphorylation-mediated inactivation of pro-apoptotic BCL-2 family protein BAD confers the apoptosis resistance on synovial sublining macrophages, thereby contributing to the development of rheumatoid arthritis.
7. 1. Chromosomes and Gene Expression

   Viral-induced alternative splicing of host genes promotes influenza replication

   Matthew G Thompson et al.
8. 1. Computational and Systems Biology
   2. Neuroscience

   On the objectivity, reliability, and validity of deep learning enabled bioimage analyses

   Dennis Segebarth et al.

   A comparison of different bioimage analysis pipelines reveals how deep learning can be used for automatized and reliable analysis of fluorescent features in biological datasets.
9. 1. Cell Biology
   2. Physics of Living Systems

   Concerted action of kinesins KIF5B and KIF13B promotes efficient secretory vesicle transport to microtubule plus ends

   Andrea Serra-Marques et al.

   The function and distribution of kinesin motors on exocytotic vesicles is dissected and visualized through a combination of gene knockout experiments, high-resolution microscopy and advanced data analysis.
10. 1. Developmental Biology
    2. Evolutionary Biology

    Conservation of peripheral nervous system formation mechanisms in divergent ascidian embryos

    Joshua F Coulcher et al.

    Developmental regulatory mechanisms for peripheral nervous system formation appear to be conserved in ascidians despite extensive genomic divergence after 390 MY of separate evolution.