Latest research

1. 1. Neuroscience

   Pupal behavior emerges from unstructured muscle activity in response to neuromodulation in Drosophila

   Amicia D Elliott et al.

   The elementary units of a fruit fly behavioral sequence are described at single-muscle resolution and shown to exhibit variability that is subject to neuromodulatory regulation.
2. 1. Computational and Systems Biology
   2. Structural Biology and Molecular Biophysics

   Development of antibacterial compounds that constrain evolutionary pathways to resistance

   Yanmin Zhang et al.

   Integrated multi-scale, multi-tool approach to design novel 'evolution drugs' which can delay the emergence of antibiotic resistance by constraining bacterial evolutionary escape strategies.
3. 1. Neuroscience
   2. Stem Cells and Regenerative Medicine

   AAV ablates neurogenesis in the adult murine hippocampus

   Stephen Johnston et al.

   Future work using recombinant AAV as an experimental tool in the dentate gyrus or as a gene therapy for diseases of the central nervous system should be carefully evaluated.
4. 1. Medicine
   2. Microbiology and Infectious Disease

   Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes

   Nguyen Lam Vuong et al.

   Relationships of biomarkers with clinical outcome differed between children and adults and the best combinations associated with moderate/severe dengue comprised of six/seven vascular and immune biomarkers.
5. 1. Evolutionary Biology
   2. Physics of Living Systems

   Price equation captures the role of drug interactions and collateral effects in the evolution of multidrug resistance

   Erida Gjini, Kevin B Wood

   A simple mathematical model reveals that antibiotic interactions and collateral effects of evolution are inseparable drivers of multidrug resistance linked by the well-known Price equation from evolutionary theory.
6. 1. Cell Biology
   2. Developmental Biology

   SOX21 modulates SOX2-initiated differentiation of epithelial cells in the extrapulmonary airways

   Evelien Eenjes et al.

   The balance between SOX2 and SOX21 is evolutionary conserved and is important for cell fate decision during lung epithelium development and repair after damage.
7. 1. Physics of Living Systems

   Effect of malaria parasite shape on its alignment at erythrocyte membrane

   Anil K Dasanna et al.

   A numerical model of malaria parasite adhesion to an erythrocyte shows that the original egg-like shape of merozoites is more robust than other shapes in negotiating various physiological conditions during the alignment process upon erythrocyte invasion.
8. 1. Cell Biology
   2. Developmental Biology

   Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules

   Patricia Giselle Cipriani et al.

   Two novel LOTUS-domain proteins are core germ granule components that directly recruit Caenorhabditis elegans Vasa, regulate germ granule size and localization, and provide an organizational framework for ribonucleoprotein complexes.
9. 1. Neuroscience

   An hourglass circuit motif transforms a motor program via subcellularly localized muscle calcium signaling and contraction

   Steven R Sando et al.

   By driving the localized contraction of subcellular muscle regions, a single motor neuron reverses the flow of material in the Caenorhabditis elegans pharynx, a neuromuscular pump, converting feeding into spitting.
10. 1. Neuroscience

    Value signals guide abstraction during learning

    Aurelio Cortese et al.

    Valuation of sensory information in the ventromedial prefrontal cortex plays a key function in constructing the abstract representations that guide complex behaviours.