Latest research

1. 1. Cell Biology

   Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore

   Evgeniya Trofimenko et al.

   Cationic cell-penetrating peptides (CPPs) enter cells through ~2 (–5)-nm-wide water pores induced by the strong negative plasma membrane potential that CPPs and the activity of potassium channels generate.
2. 1. Neuroscience

   Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice

   Julia A Kuhn et al.

   Intrathecal injection of CSF1 induces greater upregulation of spinal microglial genes in male versus female mice, however, Treg depletion enhances microglial activation and restores pain hypersensitivity in the female mice.
3. 1. Cell Biology
   2. Stem Cells and Regenerative Medicine

   Phases of cortical actomyosin dynamics coupled to the neuroblast polarity cycle

   Chet Huan Oon, Kenneth E Prehoda

   Oon and Prehoda discover cortical actomyosin dynamics that polarize asymmetrically dividing neural stem cells.
4. 1. Neuroscience

   A 3D adult zebrafish brain atlas (AZBA) for the digital age

   Justin W Kenney et al.

   A new tool for three-dimensional exploration of adult zebrafish neuroanatomy.
5. 1. Microbiology and Infectious Disease

   The Lyme disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector

   Xiaotian Tang et al.

   A new tick metabolic pathway that is connected to the survival of the Lyme disease spirochete was identified, which may lead to new ways to interfere with the spirochete life cycle.
6. 1. Immunology and Inflammation

   Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model

   Takemichi Fukasawa et al.

   Single-cell analysis revealed that autoantigen-reactive B cells changed the type of cytokines they produced from anti-inflammatory IL-10 and IL-35 to pro-inflammatory IL-6 and IL-23 as affinity to autoantigen increased.
7. 1. Immunology and Inflammation

   Histone deacetylase 3 represses cholesterol efflux during CD4⁺ T-cell activation

   Drew Wilfahrt et al.

   Histone deacetylase 3 is required for CD4+ T cells to downregulate two cholesterol efflux transport proteins, ABCA1 and ABCG1, for successful proliferation after antigenic stimulation.
8. 1. Neuroscience

   Gated recurrence enables simple and accurate sequence prediction in stochastic, changing, and structured environments

   Cédric Foucault, Florent Meyniel
9. 1. Microbiology and Infectious Disease
   2. Physics of Living Systems

   Distinguishing different modes of growth using single-cell data

   Prathitha Kar et al.
10. 1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular architecture of the human tRNA ligase complex

    Alena Kroupova et al.