• Evolution and ion channels

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  • A new way to publish

    All papers reviewed by eLife are published as Reviewed Preprints, which combine the advantages of preprints with the scrutiny offered by peer review

    Inside eLife
  • A code for RNA localization

    Experiments on RNA point to the existence of an RNA localization ‘code’ that operates in multiple cell types and is conserved across species.

    Raeann Goering, Ankita Arora ... J Matthew Taliaferro
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Latest research

    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Mitochondrial redox adaptations enable alternative aspartate synthesis in SDH-deficient cells

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    SDH-null cancer cells decrease mitochondrial complex I to drive rewired aspartate synthesis through reductive carboxylation and pyruvate carboxylase, supporting cell proliferation and tumor growth.
    1. Computational and Systems Biology

    Dynamics of co-substrate pools can constrain and regulate metabolic fluxes

    Robert West, Hadrien Delattre ... Orkun S Soyer
    Mathematical analyses explore the impact of co-substrate cycling on the dynamics of cellular metabolism, and demonstrate that these dynamics can limit cellular fluxes and that co-substrate pool dynamics can be regulated to regulate fluxes.
    1. Stem Cells and Regenerative Medicine

    Live imaging reveals chromatin compaction transitions and dynamic transcriptional bursting during stem cell differentiation in vivo

    Dennis May, Sangwon Yun ... Valentina Greco
    Chromatin gradually rearranges during epidermal stem cell differentiation, while transcription of a differentiation-associated gene is extremely dynamic.
    1. Developmental Biology
    2. Physics of Living Systems

    Controlling periodic long-range signalling to drive a morphogenetic transition

    Hugh Z Ford, Angelika Manhart, Jonathan R Chubb
    Cells control signal circulation to set the frequency of information transmitted over tissue scales.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The lingering effects of Neanderthal introgression on human complex traits

    Xinzhu Wei, Christopher R Robles ... Sriram Sankararaman
    1. Genetics and Genomics

    Native functions of short tandem repeats

    Shannon E Wright, Peter K Todd
    The mechanisms by which non-pathologic short tandem repeats normally influence gene expression and engender rapid genetic variation across phylogeny directly inform how expansions in these same repeats elicit neurological disease.
    1. Developmental Biology
    2. Evolutionary Biology

    Ectodermal Wnt signaling, cell fate determination, and polarity of the skate gill arch skeleton

    Jenaid M Rees, Victoria A Sleight ... J Andrew Gillis
    Spatially distinct ectodermal Wnt and endodermal Shh signals serve to polarize the skate gill skeleton.
    1. Structural Biology and Molecular Biophysics

    Ion permeation pathway within the internal pore of P2X receptor channels

    Stephanie W Tam, Kate Huffer ... Kenton J Swartz
    Mapping the ion permeation pathway within the internal pore of ATP-activated P2X receptor channels.
    1. Cell Biology

    Actin-regulated Siglec-1 nanoclustering influences HIV-1 capture and virus-containing compartment formation in dendritic cells

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