New target for cancer drugs

Latest research

1. 1. Cell Biology
   2. Neuroscience

   Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses

   Rituparna Chakrabarti, Lina María Jaime Tobón ... Carolin Wichmann

   Ultrastructural analysis of optogenetically stimulated inner hair cell ribbon synapses reveals normally sized synaptic vesicles and enhanced vesicle docking at the active zone membrane.
2. 1. Stem Cells and Regenerative Medicine

   Scleraxis-lineage cells are required for tendon homeostasis and their depletion induces an accelerated extracellular matrix aging phenotype

   Antonion Korcari, Anne EC Nichols ... Alayna E Loiselle

   Age-related tendon degeneration is initiated by loss of tenocytes associated with synthesis of high-turnover rate proteoglycans and glycoproteins.
3. 1. Evolutionary Biology

   Mammalian forelimb evolution is driven by uneven proximal-to-distal morphological diversity

   Priscila S Rothier, Anne-Claire Fabre ... Anthony Herrel

   The diversification of hand bones in mammals was much more dynamic than those of the proximal and intermediate forearm, involving higher morphological diversity, stronger integration, and greater evolutionary lability at distal structures.
4. 1. Ecology

   Protein feeding mediates sex pheromone biosynthesis in an insect

   Shiyu Gui, Boaz Yuval ... Daifeng Cheng

   Protein feeding stimulates the production of sex pheromones and promotes fly mating in Bactrocera dorsalis.
5. 1. Computational and Systems Biology
   2. Neuroscience

   A hardware system for real-time decoding of in vivo calcium imaging data

   Zhe Chen, Garrett J Blair ... Hugh T Blair

   DeCalciOn is a low-cost open-source hardware system for real-time in vivo calcium imaging that offers capabilities for online decoding of neural population activity and delivery of short latency closed-loop feedback in freely behaving animals.
6. 1. Microbiology and Infectious Disease

   Initiation of HIV-1 Gag lattice assembly is required for recognition of the viral genome packaging signal

   Xiao Lei, Daniel Gonçalves-Carneiro ... Paul D Bieniasz

   Initiation of the assembly of HIV-1 particles in infected cells is required to form a subviral structure that recognizes the viral RNA genome for packaging.
7. 1. Evolutionary Biology
   2. Genetics and Genomics

   Coordinated evolution at amino acid sites of SARS-CoV-2 spike

   Alexey Dmitrievich Neverov, Gennady Fedonin ... Georgii Bazykin

   Analysis of population diversity of SARS-CoV-2 revealed positive epistasis between sites carrying mutations characterizing rapidly expanding lineages.
8. 1. Computational and Systems Biology
   2. Epidemiology and Global Health

   CriSNPr: a single interface for the curated and de novo design of gRNAs for CRISPR diagnostics using diverse Cas systems

   Asgar H Ansari, Manoj Kumar ... Debojyoti Chakraborty
9. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Human influenza virus infection elicits distinct patterns of monocyte and dendritic cell mobilization in blood and the nasopharynx

   Sindhu Vangeti, Sara Falck-Jones ... Anna Smed-Sörensen
10. 1. Physics of Living Systems

    Motor processivity and speed determine structure and dynamics of microtubule-motor assemblies

    Rachel A Banks, Vahe Galstyan ... Rob Phillips