Highlights

  • Cylicins and male fertility

    Mutations in the genes for two cytoskeletal proteins found in sperm, Cylicin 1 and Cylicin 2, can lead to infertility in mice and humans.

    Simon Schneider, Andjela Kovacevic ... Hubert Schorle
    Research Article
  • The ins and outs of breathing

    Subpopulations of neurons in the pre-Bötzinger complex coordinate breathing with a range of physiological behaviors.

    Mariana R Melo, Alexander D Wykes ... Andrew M Allen
    Research Article Updated
  • Memory and multiple sclerosis

    A new approach to measuring visual working memory has revealed fresh insights into the origins of memory deficit in multiple sclerosis. (Photo: Pouria Motaghi CC-BY)

    Ali Motahharynia, Ahmad Pourmohammadi ... Mehdi Sanayei
    Research Article

Latest research

    1. Evolutionary Biology
    2. Genetics and Genomics

    Down the Penrose stairs, or how selection for fewer recombination hotspots maintains their existence

    Zachary Baker, Molly Przeworski, Guy Sella
    Modeling the evolution of PRDM9 in light of recent results implicating the importance of PRDM9 binding symmetry suggests the advantage of new PRMD9 alleles is in limiting the number of binding sites used effectively rather than increasing net binding.
    1. Neuroscience

    Modeling apical and basal tree contribution to orientation selectivity in a mouse primary visual cortex layer 2/3 pyramidal cell

    Konstantinos-Evangelos Petousakis, Ji Young Park ... Panayiota Poirazi
    1. Immunology and Inflammation

    Pulsed ultrasound promotes secretion of anti-inflammatory extracellular vesicles from skeletal myotubes via elevation of intracellular calcium level

    Atomu Yamaguchi, Noriaki Maeshige ... Hidemi Fujino
    Ultrasound promotes release of extracellular vesicles from cultured myotubes and elicits anti-inflammatory effects on macrophages, indicating the potential of ultrasound stimulation to muscle for anti-inflammatory purposes.
    1. Developmental Biology

    FMNL2 regulates actin for ER and mitochondria distribution in oocyte meiosis

    Meng-Hao Pan, Zhen-Nan Pan ... Shao-Chen Sun