Latest research

1. 1. Epidemiology and Global Health
   2. Medicine

   Type 2 diabetes mellitus accelerates brain aging and cognitive decline: Complementary findings from UK Biobank and meta-analyses

   Botond Antal et al.

   Patients with Type 2 diabetes show patterns of neurodegeneration consistent with accelerated brain aging, including impaired cognition and loss of brain volume, which are more severe in those with increased disease duration.
2. 1. Computational and Systems Biology
   2. Medicine

   Development and evaluation of a machine learning-based in-hospital COVID-19 disease outcome predictor (CODOP): A multicontinental retrospective study

   Riku Klén et al.

   The generalizability of CODOP in distinct world regions and its flexibility to reckon with the changing availability of hospital resources makes it a clinically useful tool potentially improving the outcome prediction and the management of COVID-19 hospitalized patients.
3. 1. Neuroscience

   Probing the segregation of evoked and spontaneous neurotransmission via photobleaching and recovery of a fluorescent glutamate sensor

   Camille S Wang et al.

   Photobleaching and recovery of a fluorescent glutamate sensor enable demonstration of the distinct spatial architectures of spontaneous versus evoked forms of glutamatergic neurotransmission within single synapses.
4. 1. Developmental Biology

   Notch controls the cell cycle to define leader versus follower identities during collective cell migration

   Zain Alhashem et al.

   Computational modelling and experimental manipulation show that Notch signalling regulates collective cell migration by allocating distinct migratory identities through the control of cell cycle progression.
5. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Mitotically heritable, RNA polymerase II-independent H3K4 dimethylation stimulates INO1 transcriptional memory

   Bethany Sump et al.

   During epigenetic transcriptional memory in budding yeast, histone H3 lysine 4 dimethylation - dependent on Nup1000 and independent of RNA polymerase II - regulates binding of a critical transcription factor and, once established, is mitotically heritable for at least four cell divisions.
6. 1. Physics of Living Systems

   Residual force enhancement is affected more by quadriceps muscle length than stretch amplitude

   Patrick Bakenecker et al.

   Increasing muscle length, rather than increasing stretch amplitude, contributes more to residual force enhancement during submaximal voluntary contractions of the human quadriceps.
7. 1. Ecology

   Regional opportunities for tundra conservation in the next 1000 years

   Stefan Kruse, Ulrike Herzschuh

   The treeline follows climate warming with a severe time lag, but migration rates are increasing so that only under ambitious mitigation efforts will 30% of original tundra areas remain in the north in the long run.
8. 1. Neuroscience

   Spatial signatures of anesthesia-induced burst-suppression differ between primates and rodents

   Nikoloz Sirmpilatze et al.

   Functional imaging (fMRI) across four mammalian species maps the brain areas engaging in burst-suppression activity during anesthesia, and uncovers differences between primates and rodents.
9. 1. Biochemistry and Chemical Biology
   2. Epidemiology and Global Health

   Association of egg consumption, metabolic markers, and risk of cardiovascular diseases: A nested case-control study

   Lang Pan et al.

   The associations of egg consumption with metabolic markers and of these markers with cardiovascular disease (CVD) risk showed opposite directions, which may partially explain the protective effect of moderate egg consumption on CVD in the Chinese population.
10. 1. Neuroscience

    Slow fluctuations in ongoing brain activity decrease in amplitude with ageing yet their impact on task-related evoked responses is dissociable from behavior

    Maria Ribeiro, Miguel Castelo-Branco

    The explanation of why older people show increased behavioral variability despite having decreased neural signal variability lies in the link between the dynamics of the ongoing neural signal and the trial-by-trial variability of neural evoked responses.