Latest research

1. 1. Structural Biology and Molecular Biophysics

   The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels

   Alessandro Porro et al.

   Experimental and computational approaches reveal how ligand binding is coupled to voltage sensing in a HCN channels.
2. 1. Neuroscience

   Single cell transcriptome atlas of the Drosophila larval brain

   Clarisse Brunet Avalos et al.

   Single-cell transcriptomics identifies cellular composition of the first instar Drosophila brain and the response to starvation.
3. 1. Neuroscience

   High-throughput microcircuit analysis of individual human brains through next-generation multineuron patch-clamp

   Yangfan Peng et al.

   Combining a multineuron patch-clamp system with an automated pipette pressure and cleaning device enables efficient screening of synaptic connectivity in human brain slices and allows inter-individual comparison.
4. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Distinct roles for S. cerevisiae H2A copies in recombination and repeat stability, with a role for H2A.1 threonine 126

   Nealia CM House et al.
5. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds

   Cristina Manatschal et al.
6. 1. Developmental Biology
   2. Neuroscience

   Gradient-independent Wnt signaling instructs asymmetric neurite pruning in C. elegans

   Menghao Lu, Kota Mizumoto

   Genetic analyses revealed the critical role of local Wnt in neuronal patterning by instructing neurite pruning.
7. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-coupling

   Pim J Huis in 't Veld et al.
8. 1. Neuroscience

   Insights into the dynamic control of breathing revealed through cell-type-specific responses to substance P

   Nathan A Baertsch, Jan-Marino Ramirez
9. 1. Neuroscience

   The representational space of observed actions

   Raffaele Tucciarelli et al.

   Representational similarity analysis of human functional magnetic resonance imaging data demonstrates that the lateral occipitotemporal cortex represents action knowledge along dimensions that are in accordance with behavioural judgements.
10. 1. Neuroscience

    Spatiotemporal constraints on optogenetic inactivation in cortical circuits

    Nuo Li et al.

    Electrophysiology measurements characterized eight optogenetic methods, including a new reporter mouse expressing soma-localized light-activated chloride channels, for inactivating small regions of mouse neocortex.