Latest research

1. 1. Neuroscience

   Variability in the Munc13-1 content of excitatory release sites

   Maria Rita Karlocai et al.

   Different numbers of Munc13-1 molecules build up the specialized regions of the presynaptic plasma membrane called the release sites.
2. 1. Biochemistry and Chemical Biology

   De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition

   Erich Stefan et al.

   By random nonstandard peptide integrated discovery, combinatorial macrocyclic peptides were leavaged that target a heterodimeric ABC transport complex and explore fundamental principles of the substrate translocation cycle.
3. 1. Physics of Living Systems

   Confinement discerns swarmers from planktonic bacteria

   Weijie Chen et al.

   For the same bacterial strain, the swarming phenotype can be biophysically discerned from swimming phenotype based on the motion pattern under circular confinement on a soft agar.
4. 1. Cell Biology

   Compartment-specific opioid receptor signaling is selectively modulated by different dynorphin peptides

   Jennifer M Kunselman et al.

   Different dynorphins, which signal similarly from the cell surface, can differentially localize G protein-coupled receptors to specific subcellular compartments and cause divergent receptor fates and distinct spatiotemporal patterns of signaling.
5. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   ImmunoCluster provides a computational framework for the nonspecialist to profile high-dimensional cytometry data

   James W Opzoomer et al.

   ImmunoCluster permits nonspecialist users to interrogate liquid and imaging mass, and flow cytometry datasets, resolving novel layers of cellular heterogeneity and insight, as well as producing publishable outputs and figures.
6. 1. Neuroscience

   Multiple decisions about one object involve parallel sensory acquisition but time-multiplexed evidence incorporation

   Yul HR Kang et al.

   When making two decisions about one object, two streams of information can be acquired in parallel but must be incorporated into the two decisions serially, consistent with a central bottleneck.
7. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   The final step of 40S ribosomal subunit maturation is controlled by a dual key lock

   Laura Plassart et al.

   Cryo-EM and functional studies reveal how combined action of proteins RPS26/eS26 and RIO1 allows late precursors to the human small ribosomal particle to be matured into fully translation-competent 40S subunits.
8. 1. Biochemistry and Chemical Biology

   Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine

   Qiang Liu et al.

   Identifying and understanding that local anesthetic dyclonine targets TRPV3 channels will help to conceive therapeutic interventions.
9. 1. Neuroscience

   Adapting non-invasive human recordings along multiple task-axes shows unfolding of spontaneous and over-trained choice

   Yu Takagi et al.
10. 1. Cell Biology
    2. Neuroscience

    The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains

    Vladimir Zhemkov et al.

    Signaling function of sigma 1 receptor is related to its ability to organize cholesterol-enriched microdomains in the endoplasmic reticulum membrane.