Latest research

1. 1. Plant Biology

   CASP microdomain formation requires cross cell wall stabilization of domains and non-cell autonomous action of LOTR1

   Andreas Kolbeck et al.

   Localized lignin impregnations, forming a pan-endodermal net-like diffusion barrier strongly relies on stabilizing signals from neighbors.
2. 1. Biochemistry and Chemical Biology
   2. Developmental Biology

   Maternal diet-induced obesity during pregnancy alters lipid supply to mouse E18.5 fetuses and changes the cardiac tissue lipidome in a sex-dependent manner

   Lucas C Pantaleão et al.

   Maternal obesity alters the fetal cardiac and serum lipidome, promoting early fetal cardiac metabolic maturation, with evidence that the female heart lipidome is more responsive to an in utero obesogenic environment.
3. 1. Evolutionary Biology
   2. Genetics and Genomics

   Unique structure and positive selection promote the rapid divergence of Drosophila Y chromosomes

   Ching-Ho Chang et al.

   Differences in the usage of DNA repair pathways may give rise to the unique patterns of Y-linked mutations that, together with natural selection, shape rapid Y chromosome evolution.
4. 1. Cell Biology
   2. Structural Biology and Molecular Biophysics

   SSNA1 stabilizes dynamic microtubules and detects microtubule damage

   Elizabeth J Lawrence et al.

   SSNA1 is a potent microtubule stabilizer and novel sensor of microtubule damage, acting on both microtubule ends and lattices to regulate microtubule dynamics and protect microtubules against severing activity.
5. 1. Microbiology and Infectious Disease

   Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection

   Zaigham Abbas Rizvi et al.

   SARS-CoV-2 infection in hamsters causes cardiovascular pathologies.
6. 1. Cell Biology

   A phosphoswitch at acinus-serine⁴³⁷ controls autophagic responses to cadmium exposure and neurodegenerative stress

   Nilay Nandi et al.

   The metal-dependent protein phosphatase Nilkantha, a Drosophila PPM1A/B homolog, dephosphorylates Acinus thereby restraining starvation-independent autophagy.
7. 1. Cell Biology
   2. Immunology and Inflammation

   RNA N⁶-methyladenosine modulates endothelial atherogenic responses to disturbed flow in mice

   Bochuan Li et al.

   METTL3 and m6A modifications could alleviate endothelial activation and atherogenesis through accelerated degradation of oscillatory flow-induced EGFR mRNA expression.
8. 1. Computational and Systems Biology
   2. Neuroscience

   Sex differences in learning from exploration

   Cathy S Chen et al.

   A new computational analysis of decision making in mice shows sex biases in value-updating while exploring unknown options, with male mice tending to explore longer than females due to updating values more slowly.
9. 1. Microbiology and Infectious Disease

   Multi-omics investigation of Clostridioides difficile-colonized patients reveals pathogen and commensal correlates of C. difficile pathogenesis

   Skye RS Fishbein et al.

   Integration of clinical patient data, pathogen information and a multi-omic analysis of the gut microbiome reveals key determinants of disease in C. difficile-colonized patients.
10. 1. Cell Biology
    2. Microbiology and Infectious Disease

    Adaptation of the periplasm to maintain spatial constraints essential for cell envelope processes and cell viability

    Eric Mandela et al.