Latest research

1. 1. Computational and Systems Biology
   2. Neuroscience

   Discovering and deciphering relationships across disparate data modalities

   Joshua T Vogelstein et al.

   Multiscale Graph Correlation, an interpretable hypothesis test with strong theoretical guarantees for discerning relationships in complex data, requires about half the sample size as other methods, whilst maintaining computational tractability.
2. 1. Cell Biology
   2. Developmental Biology

   Reactivation of a developmental Bmp2 signaling center is required for therapeutic control of the murine periosteal niche

   Valerie S Salazar et al.

   A periosteal Bmp2 signaling center couples bone length to bone width during development and must be reactivated by clinical bone anabolic therapies to reduce fracture risk and accelerate fracture repair.
3. 1. Biochemistry and Chemical Biology

   Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides

   Matthijs Kol et al.

   Photoswitchable ceramides containing an azobenzene photoswitch behave as light-controllable substrates for both sphingomyelin synthase and glucosylceramide synthase.
4. 1. Developmental Biology
   2. Neuroscience

   Temporal identity establishes columnar neuron morphology, connectivity, and function in a Drosophila navigation circuit

   Luis F Sullivan et al.

   The Eyeless/Pax6 temporal transcription factor generates neuronal identity, connectivity, and flight navigation behavior within the conserved adult brain structure called the central complex.
5. 1. Neuroscience

   Optogenetically induced low-frequency correlations impair perception

   Anirvan S Nandy et al.
6. 1. Neuroscience

   The impact of pathological high-frequency oscillations on hippocampal network activity in rats with chronic epilepsy

   Laura A Ewell et al.

   A novel framework for separating normal and pathological high-frequency oscillations in animals with epilepsy uncovers new mechanisms for impaired hippocampal network function.
7. 1. Developmental Biology
   2. Physics of Living Systems

   The proneural wave in the Drosophila optic lobe is driven by an excitable reaction-diffusion mechanism

   David J Jörg et al.

   A model of signalling pathways interacting with proneural gene expression explains the sequential patterning of the largest visual processing centre in the developing Drosophila brain.
8. 1. Developmental Biology
   2. Neuroscience

   The cellular basis of mechanosensory Merkel-cell innervation during development

   Blair A Jenkins et al.

   Touch-sensitive neurons are patterned during mammalian skin development by placode-derived keratinocytes and Bone Morphogenetic Protein signaling.
9. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Panton-Valentine leucocidin is the key determinant of Staphylococcus aureus pyomyositis in a bacterial GWAS

   Bernadette C Young et al.
10. 1. Cell Biology

    Electron cryo-tomography provides insight into procentriole architecture and assembly mechanism

    Sam Li et al.

    A detailed description of the structure of procentriole MT triplet by cryoET, along with its associated non-tubulin proteins and its assembly intermediates, reveals possible molecular mechanism for the procentriole assembly.