eLife works to improve research communication through open science and open technology innovation

Latest research

    1. Developmental Biology

    Cell-state transitions and collective cell movement generate an endoderm-like region in gastruloids

    Ali Hashmi et al.
    A cellular and biophysical study on embryonic stem cell aggregates reveals that the endoderm can form by a three-step mechanism involving a Wnt/beta-catenin-mediated epiblast fragmentation, tissue flow and cell segregation.
    1. Developmental Biology
    2. Genetics and Genomics

    Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction

    Alex Cornean et al.
    An integrated framework for in vivo base edting allows to scalably validate candidate genes and DNA variants.
    1. Cell Biology
    2. Physics of Living Systems

    Leading edge maintenance in migrating cells is an emergent property of branched actin network growth

    Rikki M Garner, Julie A Theriot
    Computational simulations of actin network growth at the cell leading edge, combined with careful high-speed video microscopy measurements of leading edge shape fluctuations, suggest that Arp2/3 branching of the actin network occurs at an optimal angle to minimize fluctuations.
    1. Neuroscience

    Generation of a CRF1-Cre transgenic rat and the role of central amygdala CRF1 cells in nociception and anxiety-like behavior

    Marcus M Weera et al.
    A novel transgenic rat for studying the role of specific corticotropin-releasing factor type-1 receptor-expressing cell populations in physiology and behavior.
    1. Ecology

    Tropical land use alters functional diversity of soil food webs and leads to monopolization of the detrital energy channel

    Zheng Zhou et al.
    Tropical land use makes most soil animal groups shift to 'fast' energy channel and restructures soil food web at community level, but this change is buffered by earthworms at ecosystem (energetic) level.
    1. Biochemistry and Chemical Biology

    A cryptic K48 ubiquitin chain binding site on UCH37 is required for its role in proteasomal degradation

    Jiale Du et al.
    The proteasomal deubiquitinase UCHL5/UCH37 uses a face distinct from the canonical ubiquitin binding site to engage K48-linked ubiquitin chains and catalyze chain debranching.