Latest research

1. 1. Microbiology and Infectious Disease

   A single regulator NrtR controls bacterial NAD⁺ homeostasis via its acetylation

   Rongsui Gao et al.

   Functional definition of NrtR and the discovery of its acetylation represents a first paradigm for linking protein acetylation to bacterial central NAD⁺ metabolism.
2. 1. Biochemistry and Chemical Biology

   Ctf4 organizes sister replisomes and Pol α into a replication factory

   Zuanning Yuan et al.

   Eukaryotic replisomes are strongly connected together to replicate both sister DNAs produced from a bidirectional origin.
3. 1. Structural Biology and Molecular Biophysics

   Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation

   Xiaodi Yu et al.

   Cryo-EM structures of unliganded SLC1A5 and its complex with glutamine in outward-facing state provide insights into the substrate specificity and transport mechanism and will be helpful for developing selective inhibitors.
4. 1. Developmental Biology
   2. Evolutionary Biology

   An ancestral apical brain region contributes to the central complex under the control of foxQ2 in the beetle Tribolium

   Bicheng He et al.
5. 1. Physics of Living Systems

   Plasticity of cell migration resulting from mechanochemical coupling

   Yuansheng Cao et al.

   Computational and experimental studies show that different migration modes of eukaryotic cells are the result of the interplay between signaling waves and cell mechanics.
6. 1. Neuroscience

   Independent representations of ipsilateral and contralateral limbs in primary motor cortex

   Ethan A Heming et al.
7. 1. Neuroscience

   A bidirectional network for appetite control in larval zebrafish

   Caroline Lei Wee et al.

   Brain imaging and behavioral analysis reveal two opposing states of hunger, represented by anti-correlated lateral and caudal hypothalamic dynamics that are important for the homeostatic control of feeding in zebrafish.
8. 1. Neuroscience

   Monosynaptic tracing maps brain-wide afferent oligodendrocyte precursor cell connectivity

   Christopher W Mount et al.

   Oligodendrocyte precursor cells receive brain-wide, circuit-specific intracortical, coritcocortical and thalamocortical synaptic inputs.
9. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1

   Xiaocheng Zhao et al.

   The cAMP-dependent protein kinase A controls the switch from actively sprouting new blood vessel formation to vessel quiescence by reducing endothelial autophagy through phosphorylation-mediated destabilisation of ATG16L1.
10. 1. Microbiology and Infectious Disease

    Sexual transmission of murine papillomavirus (MmuPV1) in Mus musculus

    Megan E Spurgeon, Paul F Lambert

    MmuPV1, a papillomavirus that infects laboratory mice (Mus musculus), is discovered to be sexually transmitted, providing a new animal virus model to study sexually transmitted human papillomaviruses (HPVs).