Latest research

1. 1. Cell Biology
   2. Developmental Biology

   Myofibril diameter is set by a finely tuned mechanism of protein oligomerization in Drosophila

   Nicanor González-Morales et al.

   Myofibril diameter is set by the controlled oligomerization of the PDZ and LIM domain protein Zasp in Drosophila.
2. 1. Biochemistry and Chemical Biology

   Specific lid-base contacts in the 26s proteasome control the conformational switching required for substrate degradation

   Eric R Greene et al.

   The 26S proteasome lid subcomplex acts as an external scaffold whose interactions with the ATPase motor stabilize the substrate-engagement-competent state, and control conformational changes upon engagement for subsequent degradation steps.
3. 1. Microbiology and Infectious Disease

   Interspecies interactions induce exploratory motility in Pseudomonas aeruginosa

   Dominique H Limoli et al.

   Pseudomonas aeruginosa coordinates invasion and destruction of Staphylococcus aureus communities by modulating single-cell and collective motility.
4. 1. Cell Biology
   2. Genetics and Genomics

   Micronuclei-based model system reveals functional consequences of chromothripsis in human cells

   Maja Kneissig et al.

   A method to generate human cells with massive chromosomal aberrations on a specific chromosome allows analysis of their consequences.
5. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Extraction of active RhoGTPases by RhoGDI regulates spatiotemporal patterning of RhoGTPases

   Adriana E Golding et al.

   Through visualization of directly-labeled RhoGTPase both in vitro and in vivo, RhoGDI is found to spatiotemporally regulate RhoGTPase activity through the extraction of active RhoGTPase.
6. 1. Cell Biology
   2. Developmental Biology

   Telophase correction refines division orientation in stratified epithelia

   Kendall J Lough et al.
7. 1. Cancer Biology
   2. Cell Biology

   Axon-like protrusions promote small cell lung cancer migration and metastasis

   Dian Yang et al.
8. 1. Evolutionary Biology
   2. Plant Biology

   Asymmetrical diversification of the receptor-ligand interaction controlling self-incompatibility in Arabidopsis

   Maxime Chantreau et al.

   In-planta ancestral protein resurrection of the female determinant of self-incompatibility specificity in Arabidopsis halleri demonstrates that two allelic variants currently segregating as distinct receptor-ligand combinations diverged through an asymmetrical process.
9. 1. Cancer Biology
   2. Human Biology and Medicine

   Improving drug discovery using image-based multiparametric analysis of the epigenetic landscape

   Chen Farhy et al.

   A novel phenotypic screening platform based on immunofluorescent imaging of histone modifications enables accurate identification of cell fates and environmental perturbations.
10. 1. Human Biology and Medicine
    2. Immunology and Inflammation

    A tissue-like platform for studying engineered quiescent human T-cells’ interactions with dendritic cells

    Enas Abu-Shah et al.

    The use of advanced 3D culture systems with engineered quiescent human T-cells, mimicking in vivo cellular dynamics, paves the way to a new era of much needed pre-clinical research tools.