• The origin of hagfish slime

    Microscopy studies and transcriptome analyses have shown that the slime glands of hagfish evolved from cells and genes expressed in the skin.

    Yu Zeng, David C Plachetzki ... Douglas Fudge
    Research Article
  • A new way to publish

    All papers reviewed by eLife are published as Reviewed Preprints, which combine the advantages of preprints with the scrutiny offered by peer review

    Inside eLife
  • A code for RNA localization

    Experiments on RNA point to the existence of an RNA localization ‘code’ that operates in multiple cell types and is conserved across species.

    Raeann Goering, Ankita Arora ... J Matthew Taliaferro
    Research Article

Latest research

    1. Evolutionary Biology

    Dating the origin and spread of specialization on human hosts in Aedes aegypti mosquitoes

    Noah H Rose, Athanase Badolo ... Carolyn S McBride
    The dengue and yellow fever mosquito first specialized on humans about 5000 years ago, but appears to use the same genes to thrive in urban environments today.
    1. Developmental Biology

    A gene regulatory network for neural induction

    Katherine E Trevers, Hui-Chun Lu ... Claudio D Stern
    A comprehensive resource based on analysis of the responses of embryonic ectoderm cells to signals from the 'organizer' (the node) including transcriptional responses and epigenetic changes with fine temporal dynamics, predicted regulatory interactions, and conservation among vertebrates.
    1. Genetics and Genomics

    Quantitative proteomic analysis of skeletal muscles from wild-type and transgenic mice carrying recessive Ryr1 mutations linked to congenital myopathies

    Jan Eckhardt, Alexis Ruiz ... Francesco Zorzato
    Quantitative proteomic analysis shows that recessive Ryr1 mutations not only decrease the content of RyR1 protein in muscle, but also affect the content of many other proteins involved in a variety of biological processes.
    1. Computational and Systems Biology

    Generative power of a protein language model trained on multiple sequence alignments

    Damiano Sgarbossa, Umberto Lupo, Anne-Florence Bitbol
    An iterative procedure using language models allows the generation of sequences from protein families, which score similarly to natural and experimentally validated sequences, with particular promise for small families.
    1. Neuroscience

    THINGS-data, a multimodal collection of large-scale datasets for investigating object representations in human brain and behavior

    Martin N Hebart, Oliver Contier ... Chris I Baker
    THINGS-data reflects three large-scale neuroimaging and behavioral datasets of object processing in humans, comprising densely sampled functional MRI and magnetoencephalographic recordings, as well as 4.70 million similarity judgments in response to thousands of photographic images for up to 1854 objects.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel

    Peter R Strege, Luke M Cowan ... Arthur Beyder
    Force applied to the cell membrane reversibly changes a voltage-insensitive gating step of a prokaryotic voltage-gated sodium channel.
    1. Cancer Biology
    2. Computational and Systems Biology

    Interrogating the precancerous evolution of pathway dysfunction in lung squamous cell carcinoma using XTABLE

    Matthew Roberts, Julia Ogden ... Carlos Lopez-Garcia
    XTABLE is the first easy-to-use bioinformatic solution that has been conceived and designed solely to interrogate the transcriptomes of premalignant stages of lung squamous cell carcinoma (LUSC) and enhance the development of LUSC prevention and detection strategies.
    1. Cell Biology

    Identification of Candidate Mitochondrial Inheritance Determinants Using the Mammalian Cell-Free System

    Dalen Zuidema, Alexis Jones ... Peter Sutovsky