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Latest research

    1. Microbiology and Infectious Disease

    Typhoid toxin sorting and exocytic transport from Salmonella Typhi-infected cells

    Shu-Jung Chang et al.
    A multidisciplinary approach provides a description of the exocytic pathway that exports Salmonella Typhi's typhoid toxin from infected cells.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Structure of the IL-27 quaternary receptor signaling complex

    Nathanael A Caveney et al.
    The cryogenic-electron microscopy structure of IL-27 bound to receptors, IL-27Rα and gp130, revealing a three-site assembly mechanism and overall topology and molecular details reminiscent of IL-6 but distinct from related IL-12 and IL-23.
    1. Neuroscience

    A tonic nicotinic brake controls spike timing in striatal spiny projection neurons

    Lior Matityahu et al.
    A novel mechanism describes how tonic activation of nicotinic acetylcholine receptors can modulate the timing of striatal output by priming feedforward inhibition.
    1. Cell Biology
    2. Immunology and Inflammation

    A B-cell actomyosin arc network couples integrin co-stimulation to mechanical force-dependent immune synapse formation

    Jia C Wang et al.
    B-cell integrin co-stimulation promotes the formation of an actomyosin network that drives integrin-dependent immune synapse formation and B-cell activation.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Radiocarbon and genomic evidence for the survival of Equus Sussemionus until the late Holocene

    Dawei Cai et al.
    The first nuclear genomes of the Equus (Sussemionus) ovodovi enable us to reconstruct the speciation and extinction trajectory of this lineage.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells

    Le Xiong et al.
    Time-resolved multiomics analysis during Oct4 depletion and recovery reveals concentration-dependent activities of Oct4 in controlling enhancer transcription and chromatin accessibility in mouse embryonic stem cells.
    1. Neuroscience

    Higher-order olfactory neurons in the lateral horn support odor valence and odor identity coding in Drosophila

    Sudeshna Das Chakraborty et al.
    Two-photon functional imaging linked to olfactory preference in Drosophila provides the first understanding of how odors are integrated, transformed, and represented in the lateral horn by an ensemble of higher-order glutamatergic lateral horn neurons.
    1. Computational and Systems Biology
    2. Neuroscience

    Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson’s disease

    Timon Merk et al.
    Advanced machine learning based brain signal decoding of grip-force as a proxy for movement vigor shows Parkinson's disease related performance reduction, suggestive of a loss of cortical vigor encoding in the absence of dopamine.