• ERK3 in control

    The kinase ERK3 influences the motility of tumor cells by controlling a previously unknown regulatory pathway.

    Katarzyna Bogucka-Janczi, Gregory Harms ... Krishnaraj Rajalingam
    Research Advance Updated
  • Ultrafast cortical oscillations

    Optogenetic activation of thalamocortical axons produces ultrafast oscillations in cortical layer 4, along with responses in interneurons and excitatory cells.

    Hang Hu, Rachel E Hostetler, Ariel Agmon
    Research Article Updated
  • Update on eLife’s new model

    In the first three months, we have seen consistent submissions and positive feedback from authors.

    Inside eLife

Latest research

    1. Neuroscience

    Prolonged nicotine exposure reduces aversion to the drug in mice by altering nicotinic transmission in the interpeduncular nucleus

    Sarah Mondoloni, Claire Nguyen ... Alexandre Mourot
    Inter-individual variabilities in nicotine aversion are linked with responses of the interpeduncular nucleus to the drug.
    1. Neuroscience

    Are single-peaked tuning curves tuned for speed rather than accuracy?

    Movitz Lenninger, Mikael Skoglund ... Arvind Kumar
    Single-peaked tuning curves found in early sensory areas are more optimized for quick decoding than accuracy, while multi-peaked tuning curves (e.g. grid cells) give higher accuracy but only at longer time scales.
    1. Genetics and Genomics
    2. Neuroscience

    Tau polarizes an aging transcriptional signature to excitatory neurons and glia

    Timothy Wu, Jennifer M Deger ... Joshua M Shulman
    While tau and aging have highly overlapping differential gene expression signatures, they diverge in the affected cell types, with aging having a wide-ranging impact and tau-triggered changes instead polarized to excitatory neurons and glia.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Substrate stiffness impacts early biofilm formation by modulating Pseudomonas aeruginosa twitching motility

    Sofia Gomez, Lionel Bureau ... Sigolene Lecuyer
    The spatial organization of pathogenic bacteria into microcolonies can be shaped by the stiffness of the substrate that they colonize, via modifications of the bacterial motility.
    1. Cell Biology

    Global analysis of contact-dependent human-to-mouse intercellular mRNA and lncRNA transfer in cell culture

    Sandipan Dasgupta, Daniella Y Dayagi ... Jeffrey E Gerst
    The RNA transferome comprises full-length mRNAs and lncRNAs that undergo non-selective and expression-dependent transfer between mammalian cells in culture via actin-based tunneling nanotubes.
    1. Neuroscience

    Cortico-thalamo-cortical interactions modulate electrically evoked EEG responses in mice

    Leslie D. Claar, Irene Rembado ... Christof Koch