Latest research

1. 1. Chromosomes and Gene Expression
   2. Developmental Biology

   Rif1 inhibits replication fork progression and controls DNA copy number in Drosophila

   Alexander Munden et al.

   To regulate DNA copy number during development in Drosophila, the SUUR protein recruits Rif1 to replisomes where Rif1 inhibits replication fork progression, thus controlling copy number independently of origin firing.
2. 1. Computational and Systems Biology
   2. Genetics and Genomics

   New insights into the cellular temporal response to proteostatic stress

   Justin Rendleman et al.

   A time-resolved analysis of protein and RNA concentrations and interactions during proteostasis stress highlights the dominant role of translation regulation and a shift of energy metabolism.
3. 1. Neuroscience

   ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines

   Shu-Xia Cao et al.

   Behavioral and molecular mechanistic studies elaborate the important role of ErbB4 in noradrenergic neurons associated with mania pathogenesis.
4. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   UBE2G1 governs the destruction of cereblon neomorphic substrates

   Gang Lu et al.

   Cereblon-based small-molecule degraders rely on the sequential action of ubiquitin-conjugating enzymes UBE2G1 and UBE2D3 to assemble K48-linked polyubiquitin chains on cereblon neomorphic substrates, resulting in their proteasomal degradation.
5. 1. Neuroscience

   Receptive field center-surround interactions mediate context-dependent spatial contrast encoding in the retina

   Maxwell H Turner et al.

   In the retina, the receptive field surround preserves the spatial contrast sensitivity of the center in the face of naturalistic changes in local luminance.
6. 1. Neuroscience

   Central Dicer-miR-103/107 controls developmental switch of POMC progenitors into NPY neurons and impacts glucose homeostasis

   Sophie Croizier et al.
7. 1. Microbiology and Infectious Disease

   Chromatin mapping identifies BasR, a key regulator of bacteria-triggered production of fungal secondary metabolites

   Juliane Fischer et al.
8. 1. Structural Biology and Molecular Biophysics

   Calcium-dependent electrostatic control of anion access to the pore of the calcium-activated chloride channel TMEM16A

   Andy K M Lam, Raimund Dutzler
9. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids

   Anna Yoney et al.
10. 1. Neuroscience

    Sensory experience inversely regulates feedforward and feedback excitation-inhibition ratio in rodent visual cortex

    Nathaniel J Miska et al.