Latest research

1. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs

   Bert van de Kooij et al.

   The human NimA-related kinases (Neks) recognize divergent substrate motifs, and include Nek10 as a dual-specificity serine/tyrosine kinase, and Nek6, Nek7 and Nek9 as amplifiers of the Plk1 phospho-motif.
2. 1. Neuroscience

   Post-decision processing in primate prefrontal cortex influences subsequent choices on an auditory decision-making task

   Joji Tsunada et al.

   A behavioral model, neuronal recordings, and electrical microstimulation reveal that the ventrolateral prefrontal cortex plays a causal role in evaluating prior decisions and biasing future decisions.
3. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   Transcriptome maps of general eukaryotic RNA degradation factors

   Salma Sohrabi-Jahromi et al.

   Mapping of 30 general RNA degradation factors onto the yeast transcriptome provides the global distribution of factors for RNA turnover and surveillance in a eukaryotic cell.
4. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   HSV-1 single-cell analysis reveals the activation of anti-viral and developmental programs in distinct sub-populations

   Nir Drayman et al.

   Single-cell analyses of cells infected by Herpes Simplex Virus 1 revealed extreme heterogeneity among infected cells, including the robust activation of developmental gene programs in highly infected cells.
5. 1. Cell Biology

   PLK4 promotes centriole duplication by phosphorylating STIL to link the procentriole cartwheel to the microtubule wall

   Tyler Chistopher Moyer, Andrew Jon Holland

   Cell biological, biochemical, and genetic analyses reveal that PLK4 controls two different phospho-dependent binding interactions that act together to promote procentriole assembly.
6. 1. Neuroscience

   Accelerated redevelopment of vocal skills is preceded by lasting reorganization of the song motor circuitry

   Michiel Vellema et al.

   The ability to quickly re-acquire a previously lost motor skill is associated with lasting synaptic changes in the brain circuit that controls that motor skill.
7. 1. Neuroscience

   Coding strategies in the otolith system differ for translational head motion vs static orientation relative to gravity

   Mohsen Jamali et al.
8. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock

   Maria Azkanaz et al.

   Heat shock induces relocalization of epigenetic modifiers to the nucleolus, which acts as a dedicated protein quality control center that is indispensable for recovery of epigenetic regulators and epigenetic modifications.
9. 1. Neuroscience

   Complementary congruent and opposite neurons achieve concurrent multisensory integration and segregation

   Wen-Hao Zhang et al.

   Opposite neurons in multisensory areas compute the cue disparity information essential for information segregation.
10. 1. Cell Biology
    2. Developmental Biology

    Vps8 overexpression inhibits HOPS-dependent trafficking routes by outcompeting Vps41/Lt

    Péter Lőrincz et al.