Latest research

1. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme

   Roman O Fedoryshchak et al.

   Interaction of cofactor Phactr1 with PP1 creates a composite substrate-binding surface that defines the sequence specificity of the Phactr1/PP1 holoenzyme.
2. 1. Neuroscience

   Dopamine promotes instrumental motivation, but reduces reward-related vigour

   John P Grogan et al.

   Dopaminergic medication dissociates contingent motivation from reward expectation effects on invigoration of movements in PD patients, confirming they are separate processes with different dopaminergic functions.
3. 1. Cancer Biology

   Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen

   Hao Zhang et al.

   The HOXA9 reporter and genetic screens facilitated the functional interrogation of the HOXA9 regulome and advanced our understanding of the molecular regulation network in HOXA9-driven leukemia.
4. 1. Developmental Biology
   2. Neuroscience

   Cadherins regulate nuclear topography and function of developing ocular motor circuitry

   Athene Knüfer et al.

   Cadherin-dependent cell adhesion controls the contralateral migration and clustering of ocular motor subpopulations and is required for the development of functional eye movements driven by those neurons.
5. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis

   Massimo Ganassi et al.

   Cellular and molecular analyses reveal how Myogenin controls muscle stem cell quiescence and growth of adult muscle fibres.
6. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment

   Yukiko Imai et al.

   Biochemical and genetic approaches uncover a chromatin remodeler for PRDM9 binding and the parallel local epigenetic modification of cytosines in mouse spermatocytes.
7. 1. Structural Biology and Molecular Biophysics

   A sulfur-aromatic gate latch is essential for opening of the Orai1 channel pore

   Priscilla S-W Yeung et al.
8. 1. Neuroscience

   A low affinity cis-regulatory BMP response element restricts target gene activation to subsets of Drosophila neurons

   Anthony JE Berndt et al.
9. 1. Evolutionary Biology

   The birth of a bacterial tRNA gene by large-scale, tandem duplication events

   Gökçe B Ayan et al.
10. 1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Transcription termination and antitermination of bacterial CRISPR arrays

    Anne M Stringer et al.