Latest research

1. 1. Genetics and Genomics
   2. Neuroscience

   Modular transcriptional programs separately define axon and dendrite connectivity

   Yerbol Z Kurmangaliyev et al.

   Diverse morphologies of Drosophila T4/T5 neuronal subtypes are defined by the modular assembly of transcriptional programs for distinct wiring features.
2. 1. Chromosomes and Gene Expression
   2. Microbiology and Infectious Disease

   IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP

   Arunava Roy et al.

   The innate immune DNA sensor IFI16 is in association with H3K9 methyltransferases SUV39H1 and GLP under physiological conditions in the nucleus which facilitates the epigenetic silencing of foreign viral DNA.
3. 1. Genetics and Genomics

   An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms

   Oguz Kanca et al.

   Optimization of homology donor DNA production and integration schemes facilitates homologous recombination in vivo and in cell culture in Drosophila melanogaster..
4. 1. Cell Biology
   2. Evolutionary Biology

   A unicellular relative of animals generates a layer of polarized cells by actomyosin-dependent cellularization

   Omaya Dudin et al.

   Cellularization in Sphaeroforma arctica generates a self-organized structure that morphologically resembles an epithelium, and is associated with tightly regulated expression of cell adhesion pathways.
5. 1. Developmental Biology
   2. Evolutionary Biology

   Evolutionary loss of foot muscle during development with characteristics of atrophy and no evidence of cell death

   Mai P Tran et al.

   Evolutionary loss of foot muscle in a bipedal rodent shares similarities with skeletal muscle atrophy, which is typically considered a pathological response to injury or disease.
6. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Chromosome territory formation attenuates the translocation potential of cells

   Leah F Rosin et al.

   The translocation potential of cells can be modulated by Condensin II activity during interphase.
7. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid

   Leslie A McCauliff et al.

   Sterol kinetics and cell-based assays reveal a heretofore unknown step in cholesterol trafficking through the endolysosomal compartment, involving a direct functional interaction between NPC2 and lysosbisphosphatidic acid.
8. 1. Cell Biology
   2. Developmental Biology

   Single-cell proteomics reveals changes in expression during hair-cell development

   Ying Zhu et al.

   Protein mass spectrometry can be used to uncover developmental trajectories in small single cells of differentiating tissues.
9. 1. Structural Biology and Molecular Biophysics

   Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding

   Janelle Lauer et al.

   Understanding the complex auto-regulatory mechanisms for guanine nucleotide exchange factors is critically important for fully appreciating the layers of control for small GTPases.
10. 1. Structural Biology and Molecular Biophysics

    The ion selectivity filter is not an activation gate in TRPV1-3 channels

    Andrés Jara-Oseguera et al.