lncRNAs and the heart

Latest research

1. 1. Evolutionary Biology

   Dating the origin and spread of specialization on human hosts in Aedes aegypti mosquitoes

   Noah H Rose, Athanase Badolo ... Carolyn S McBride

   The dengue and yellow fever mosquito first specialized on humans about 5000 years ago, but appears to use the same genes to thrive in urban environments today.
2. 1. Developmental Biology

   A gene regulatory network for neural induction

   Katherine E Trevers, Hui-Chun Lu ... Claudio D Stern

   A comprehensive resource based on analysis of the responses of embryonic ectoderm cells to signals from the 'organizer' (the node) including transcriptional responses and epigenetic changes with fine temporal dynamics, predicted regulatory interactions, and conservation among vertebrates.
3. 1. Genetics and Genomics

   Quantitative proteomic analysis of skeletal muscles from wild-type and transgenic mice carrying recessive Ryr1 mutations linked to congenital myopathies

   Jan Eckhardt, Alexis Ruiz ... Francesco Zorzato

   Quantitative proteomic analysis shows that recessive Ryr1 mutations not only decrease the content of RyR1 protein in muscle, but also affect the content of many other proteins involved in a variety of biological processes.
4. 1. Computational and Systems Biology

   Generative power of a protein language model trained on multiple sequence alignments

   Damiano Sgarbossa, Umberto Lupo, Anne-Florence Bitbol

   An iterative procedure using language models allows the generation of sequences from protein families, which score similarly to natural and experimentally validated sequences, with particular promise for small families.
5. 1. Neuroscience

   THINGS-data, a multimodal collection of large-scale datasets for investigating object representations in human brain and behavior

   Martin N Hebart, Oliver Contier ... Chris I Baker

   THINGS-data reflects three large-scale neuroimaging and behavioral datasets of object processing in humans, comprising densely sampled functional MRI and magnetoencephalographic recordings, as well as 4.70 million similarity judgments in response to thousands of photographic images for up to 1854 objects.
6. 1. Structural Biology and Molecular Biophysics
   2. Cell Biology

   Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel

   Peter R Strege, Luke M Cowan ... Arthur Beyder

   Force applied to the cell membrane reversibly changes a voltage-insensitive gating step of a prokaryotic voltage-gated sodium channel.
7. 1. Cancer Biology
   2. Computational and Systems Biology

   Interrogating the precancerous evolution of pathway dysfunction in lung squamous cell carcinoma using XTABLE

   Matthew Roberts, Julia Ogden ... Carlos Lopez-Garcia

   XTABLE is the first easy-to-use bioinformatic solution that has been conceived and designed solely to interrogate the transcriptomes of premalignant stages of lung squamous cell carcinoma (LUSC) and enhance the development of LUSC prevention and detection strategies.
8. 1. Cell Biology

   Identification of Candidate Mitochondrial Inheritance Determinants Using the Mammalian Cell-Free System

   Dalen Zuidema, Alexis Jones ... Peter Sutovsky
9. 1. Cell Biology
   2. Immunology and Inflammation

   HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation

   Sara Scinicariello, Adrian Soderholm ... Gijs A Versteeg

   HUWE1 indirectly mediates the return to cellular homeostasis after pro-inflammatory responses, which it does by controling the stability of the immune suppressor tristetraprolin.
10. 1. Cell Biology

    Defects in lipid homeostasis reflect the function of TANGO2 in phospholipid and neutral lipid metabolism

    Agustin Leonardo Lujan, Ombretta Foresti ... Vivek Malhotra