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Latest research

    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia

    Margaret AM Nelson et al.
    Across a physiological span of ATP-free energy, leukemic mitochondria primarily consume, rather than produce, ATP.
    1. Epidemiology and Global Health

    Modeling the impact of racial and ethnic disparities on COVID-19 epidemic dynamics

    Kevin C Ma et al.
    Racial and ethnic disparities in SARS-CoV-2 infection rates can impact overall epidemic dynamics and herd immunity, underscoring the need to develop socially informed transmission models that account for population variability.
    1. Cell Biology
    2. Physics of Living Systems

    Variations of intracellular density during the cell cycle arise from tip-growth regulation in fission yeast

    Pascal D Odermatt et al.
    The density of the cytoplasm in S. pombe varies in time and space during the cell cycle through modulation of tip growth rate coupled with constant mass growth rate.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Multiple pathways of toxicity induced by C9orf72 dipeptide repeat aggregates and G4C2 RNA in a cellular model

    Frédéric Frottin et al.
    Protein aggregates resulting from mutations in C9orf72 impair different aspects of cellular quality control in the cytosol and the nucleus, but mRNA-mediated effects contribute more strongly to toxicity.
    1. Plant Biology

    A hypothesis on the capacity of plant odorant-binding proteins to bind volatile isoprenoids based on in silico evidences

    Deborah Giordano et al.
    It is hypothesized that volatile organic compounds emitted by plants after stress induction may be sensed by neighboring eavesdropping plants using odorant-binding proteins.
    1. Epidemiology and Global Health

    Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection

    Allison Koenecke et al.
    Patients exposed to ⍺1-AR antagonists have reduced risks of mechanical ventilation and death in lower respiratory tract infection-related illnesses, highlighting the need for prospective trials assessing ⍺1-AR antagonists' effectiveness in COVID-19.
    1. Developmental Biology
    2. Plant Biology

    Organ geometry channels reproductive cell fate in the Arabidopsis ovule primordium

    Elvira Hernandez-Lagana et al.
    In the Arabidopsis ovule primordium, germinal fate plasticity is coupled to the morphogenetic processes shaping the organ.