Latest research

1. 1. Developmental Biology

   Single-cell sequencing of neonatal uterus reveals an Misr2+ endometrial progenitor indispensable for fertility

   Hatice Duygu Saatcioglu et al.

   Single-cell RNA sequencing of neonatal uterus revealed an Misr2+ endometrial stromal progenitor whose inhibition by ectopic administration of MIS caused uterine hypoplasia and infertility in adulthood.
2. 1. Chromosomes and Gene Expression
   2. Neuroscience

   Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters

   Nikolai Petkau et al.

   Acetylation of the circadian transcription factor BMAL1 by the acetyltransferase TIP60 is crucial for recruitment of the pause release factors to clock gene promoters and productive elongation of these genes.
3. 1. Chromosomes and Gene Expression
   2. Developmental Biology

   Multi-enhancer transcriptional hubs confer phenotypic robustness

   Albert Tsai et al.

   Multiple enhancers in physical proximity can reinforce shared transcriptional 'hubs' to preserve their transcriptional output, providing a buffer during environmental stresses and genetic perturbations to preserve phenotypic robustness.
4. 1. Biochemistry and Chemical Biology
   2. Immunology and Inflammation

   N-chlorination mediates protective and immunomodulatory effects of oxidized human plasma proteins

   Agnes Ulfig et al.

   N-chlorination, a reversible, oxidative modification, turns plasma proteins into holdase-like chaperones, potent activators of immune cells and pro-survival factors for phagocytic immune cells.
5. 1. Neuroscience

   Distinct ipRGC subpopulations mediate light’s acute and circadian effects on body temperature and sleep

   Alan C Rupp et al.

   Daily fluctuations versus transient perturbations in environmental light influence behavior and physiology through distinct circuits.
6. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide

   Dominik Witzigmann et al.
7. 1. Neuroscience

   Voluntary and involuntary contributions to perceptually guided saccadic choices resolved with millisecond precision

   Emilio Salinas et al.

   Looking away from a salient visual stimulus pits the reflexive urge to look toward it against the voluntary intention not to, and this conflict is resolved within tens of milliseconds.
8. 1. Computational and Systems Biology
   2. Developmental Biology

   Modularity, criticality, and evolvability of a developmental gene regulatory network

   Berta Verd et al.

   A new approach focusing on dynamic modularity helps overcome traditional challenges detecting modularity in complex adaptive systems.
9. 1. Structural Biology and Molecular Biophysics

   ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling

   Panpan Hou et al.
10. 1. Neuroscience

    Conditional deletion of glucocorticoid receptors in rat brain results in sex-specific deficits in fear and coping behaviors

    Jessie R Scheimann et al.

    Development of a conditional glucocorticoid receptor knockdown rat model allows for high resolution anatomical, physiological and behavioral exploration into the role of glucocorticoid receptor signaling in defined cell populations.