Latest research

1. 1. Chromosomes and Gene Expression

   Dynamic relocalization of replication origins by Fkh1 requires execution of DDK function and Cdc45 loading at origins

   Haiyang Zhang et al.

   Establishment of replication-timing involves Fkh1-dependent recruitment and execution of DDK function in G1 phase resulting in dynamic relocalization of origins within the nucleus in anticipation of CDK-dependent origin activation.
2. 1. Cell Biology

   Generation of endogenous pH-sensitive EGF receptor and its application in high-throughput screening for proteins involved in clathrin-mediated endocytosis

   Mads Breum Larsen et al.

   CRISPR/Cas9 gene-editing was used to generate a novel endogenous pH-sensitive EGF receptor chimera with the unique utility to study receptor endocytosis in a single-cell and high-throughput experimental formats.
3. 1. Neuroscience

   Human macular Müller cells rely more on serine biosynthesis to combat oxidative stress than those from the periphery

   Ting Zhang et al.

   The important role of serine biosynthesis in Müller cells may explain why the macula is so much more prone to developing disease than the rest of the retina.
4. 1. Human Biology and Medicine
   2. Neuroscience

   Non-selective inhibition of inappropriate motor-tendencies during response-conflict by a fronto-subthalamic mechanism

   Jan R Wessel et al.

   Action-selection under response-conflict is buttressed by an inhibitory control signal from the basal ganglia that non-selectively suppresses motor excitability.
5. 1. Neuroscience

   Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse

   Jie Zhang et al.

   An effective and reversible mouse glaucoma model that replicates the secondary glaucoma in human patients caused by silicone oil after retina surgeries presents significant neurodegeneration, and is suitable for neuroprotectants selection.
6. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Novel RNA and DNA strand exchange activity of the PALB2 DNA binding domain and its critical role for DNA repair in cells

   Jaigeeth Deveryshetty et al.

   Biochemical studies revealed novel property of human tumor suppressor PALB2, which significantly contribute into DNA repair in cells and can be targeted for the development of novel anticancer treatment.
7. 1. Neuroscience

   Short-term plasticity at cerebellar granule cell to molecular layer interneuron synapses expands information processing

   Kevin Dorgans et al.

   Molecular, structural and functional diversity of cerebellar granule cell inputs on single molecular layer interneurons extends information processing in feed-forward inhibition microcircuits.
8. 1. Human Biology and Medicine
   2. Neuroscience

   A consensus guide to capturing the ability to inhibit actions and impulsive behaviors in the stop-signal task

   Frederick Verbruggen et al.

   Clear guidelines and open-source software resources are provided for the stop-signal task, in order to streamline the use of this important tool, and to thereby increase its validity and reliability.
9. 1. Cell Biology
   2. Structural Biology and Molecular Biophysics

   Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity

   Breane G Budaitis et al.

   Force generation by kinesin motor proteins requires formation of both a 2-stranded cover-neck bundle and an asparagine-based latch for transport of membrane-bound cargoes in cells.
10. 1. Biochemistry and Chemical Biology
    2. Cancer Biology

    An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma

    Rigney E Turnham et al.

    Fibrolamellar carcinoma results from a genetic lesion that produces the DNAJ-PKAc fusion kinase, which is recruited into macromolecular complexes and is sensitive to combinations of signal transduction inhibitor drugs.