Highlights

  • Replication in Drosophila studies

    An analysis of 400 articles on the immune response in Drosophila highlights a need for caution regarding the replicability of certain claims.

    Hannah Westlake, Fabrice David ... Bruno Lemaitre
    Reviewed Preprint Updated
  • Tsetse fly feeding adaptations

    Investigations into the biomechanics of tsetse fly blood feeding reveal that subtle anatomical adaptations enable the penetration of a diverse range of host hides.

    Stephan Löwe, Laura Hauf ... Markus Engstler
    Research Article
  • Anatomy of taste and texture

    Comprehensive ultrastructural reconstruction of the Drosophila larval pharyngeal sensory system reveals the organization and diversity of its sensory structures.

    Vincent Richter, Tilman Triphan ... Andreas S Thum
    Research Article
  • Neurosecretory connections

    Connectomic and transcriptomic analyses reveal the anatomical and functional organisation of neurosecretion in the Drosophila brain.

    Theresa H McKim, Jayati Gera ... Meet Zandawala
    Research Article
  • AI in research communication

    eLife has partnered on a number of projects harnessing AI for improving human and machine reader engagement with research.

    Inside eLife
  • Explore our new collection

    Delve into leading research on Lifestyle, Environment and Epigenetic Inheritance.

    Collection

Latest research

    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Kinesin-1 holoenzyme assembly coordinates cargo-adaptor recognition with heavy-chain autoinhibition

    Jingling Niu, Mengmeng Zhang ... Chao Wang
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience
    2. Computational and Systems Biology

    Global Nernstian astrocytic depolarization breaks down during local synaptic input

    Ryo J Nakatani, Erik De Schutter
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Congruent neuronal modulation across competing actions challenges the role of the substantia nigra in action selection

    Lingfeng Hou, Derin Timuçin ... John Assad
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Solid
    1. Cell Biology
    2. Neuroscience

    Neuropeptides NLP-10 and FLP-18 stimulate lipid catabolism in chronically diet-restricted Caenorhabditis elegans

    Jiaming Liu, Liyun Lin ... Jintao Luo
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Immunology and Inflammation

    Mouse models with human antibody repertoires for inducing multiple lineages of HIV-1 broadly neutralizing antibodies

    Ming Tian, Hwei-Ling Cheng ... Frederick W Alt
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Developmental Biology

    Gcn5 and mTORC1 mediated regulation of autophagy controls Drosophila blood cell homeostasis

    Arjun Aji Reeja, Mincy Kunjumon ... Rohan Jayant Khadilkar
    Gcn5 and mTORC1 cooperatively regulate autophagy to integrate systemic nutritional cues and sustain blood cell homeostasis in Drosophila.
    1. Neuroscience

    Distinct neural representations of perceptual and numerical absence in the human brain

    Benjy Barnett, Stephen M Fleming
    A magnetoencephalography study reveals numerical zero relies on alternative cognitive representations to non-numerical absences in a perceptual detection task.
    1. Microbiology and Infectious Disease

    A novel mechanism for morphological change during bacterial sporulation based on programmed peptidoglycan degradation

    Carlos A Ramirez Carbo, Oihane Irazoki ... Beiyan Nan
    The rod-shaped Gram-negative bacterium Myxococcus xanthus forms spherical spores by degrading its peptidoglycan cell wall using two mutually regulating enzymes.
    1. Neuroscience

    Spectraplakin is required for dendritic microtubule organization via a tip-based mechanism in Drosophila

    Matthew Davies, Neeraja Sanal ... Sebastian Rumpf
    Genetic and microscopic analyses reveal that spectraplakin is required for uniform plus end-in organization of neuronal dendritic microtubules and that it acts in a localized and developmentally transient fashion.
    1. Neuroscience

    Functional maturation in abducens motoneurons populations during angular VOR larval development

    Mathilde Pain, Marie Boulain ... François M Lambert
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing