Latest research

1. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones

   Jay F Sarthy et al.

   Deposition of mutant oncohistones by alternative nucleosome assembly pathways results in dramatic local differences in histone methylation in pediatric diffuse midline gliomas.
2. 1. Cancer Biology
   2. Developmental Biology

   SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells

   Erik Oliemuller et al.

   SOX11+ breast tumours display reactivated embryonic developmental signalling and organogenetic features and are at elevated risk of developing metastases, so may benefit from more aggressive therapies.
3. 1. Chromosomes and Gene Expression
   2. Plant Biology

   Natural variation in autumn expression is the major adaptive determinant distinguishing Arabidopsis FLC haplotypes

   Jo Hepworth et al.

   Variation in autumnal expression from starting expression levels and initial cold-down-regulation, rather than epigenetic silencing, is the major field variable conferred by worldwide haplotypes of the floral repressor gene, FLC.
4. 1. Chromosomes and Gene Expression

   Identification of protein-protected mRNA fragments and structured excised intron RNAs in human plasma by TGIRT-seq peak calling

   Jun Yao et al.

   Human plasma contains protein-protected mRNA fragments, myriad repeat RNAs, and novel intron RNAs, including a family of structured full-length excised introns, some corresponding to mirtron pre-miRNAs and agotrons.
5. 1. Developmental Biology

   A multi-layered and dynamic apical extracellular matrix shapes the vulva lumen in Caenorhabditis elegans

   Jennifer D Cohen et al.
6. 1. Biochemistry and Chemical Biology

   POMK regulates dystroglycan function via LARGE-mediated elongation of matriglycan

   Ameya S Walimbe et al.
7. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme

   Roman O Fedoryshchak et al.
8. 1. Plant Biology

   Photosynthesis without β-carotene

   Pengqi Xu et al.
9. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death

   Kuan-Yi Lu et al.

   Phosphatidylinositol 3-phosphate interacts with PfHsp70-1 and stabilizes the Plasmodium digestive vacuole under febrile temperatures.
10. 1. Evolutionary Biology
    2. Genetics and Genomics

    Symbiont-mediated cytoplasmic incompatibility: what have we learned in 50 years?

    J Dylan Shropshire et al.

    This review serves as a gateway to experimental, conceptual, and quantitative themes of cytoplasmic incompatibility (CI) and outlines significant gaps in the understanding of CI's mechanism that are ripe for investigation.