eLife is an open-access journal that publishes promising research in the life and biomedical sciences

Latest research

    1. Neuroscience

    Learning induces the translin/trax RNase complex to express activin receptors for persistent memory

    Alan Jung Park et al.
    Combination of in vitro and in vivo approaches reveal how learning suppresses the microRNA system to trigger de novo synthesis of plasticity proteins, a missing link in the current model of microRNA-mediated translation in persistent synaptic plasticity and memory.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    A transgenic toolkit for visualizing and perturbing microtubules reveals unexpected functions in the epidermis

    Andrew Muroyama, Terry Lechler
    The dynamics and functions of epidermal microtubules are revealed through the use of transgenic tools to image and perturb microtubule arrays.
    1. Developmental Biology and Stem Cells
    2. Genes and Chromosomes

    ME31B globally represses maternal mRNAs by two distinct mechanisms during the Drosophila maternal-to-zygotic transition

    Miranda Wang et al.
    ME31B is a general repressor of gene expression in the Drosophila early embryo, repressing translation before the maternal-to-zygotic transition and stimulating mRNA decay after activation of the zygotic genome.
    1. Biophysics and Structural Biology
    2. Microbiology and Infectious Disease

    Structural dynamics of RbmA governs plasticity of Vibrio cholerae biofilms

    Jiunn CN Fong et al.
    Biofilm matrix protein RbmA controls biofilm architecture through binary structural switching and exopolysaccharide binding.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    The cyanobacterial circadian clock follows midday in vivo and in vitro

    Eugene Leypunskiy et al.
    The cyanobacterial core clock tracks midday regardless of day length, which can be understood in terms of a model for how the environment alters the clock limit cycle.
    1. Microbiology and Infectious Disease

    Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer

    Janine Bowring et al.
    Structural and genetic analyses reveal the highly evolved and unprecedented biological strategy used by SaPIs to spread in nature.
    1. Cell Biology
    2. Neuroscience

    Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104

    Jiaxing Li et al.
    Synaptic defects previously attributed to loss of kinesin function are found to be mediated by the Wnd/DLK axonal injury signaling pathway, which restrains the total levels of presynaptic proteins in response to their accumulation.