Latest research

1. 1. Stem Cells and Regenerative Medicine

   Nuclear receptor NR4A is required for patterning at the ends of the planarian anterior-posterior axis

   Dayan J Li et al.

   NR4A is a broadly conserved transcription factor that is required for concordance of patterning information and anatomy at both ends of the planarian anterior-posterior axis.
2. 1. Genetics and Genomics
   2. Human Biology and Medicine

   Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis

   Satish K Nandakumar et al.

   A gene-centric functional screen uncovers biological mechanisms underlying genome-wide association study signals for human red blood cell traits.
3. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Stem cell topography splits growth and homeostatic functions in the fish gill

   Julian Stolper et al.

   The fish gill, an ever-growing organ with fast turnover rate, displays dedicated stem-cell populations for growth and homeostasis that are interchangeable upon external challenges.
4. 1. Computational and Systems Biology
   2. Neuroscience

   NetPyNE, a tool for data-driven multiscale modeling of brain circuits

   Salvador Dura-Bernal et al.

   The NetPyNE software tool provides a framework to efficiently develop, simulate, optimize and analyze experimentally grounded neural models spanning the molecular, cellular and circuit scales.
5. 1. Cell Biology

   Mammalian cell growth dynamics in mitosis

   Teemu P Miettinen et al.

   High-resolution single-cell mass accumulation and protein synthesis rate measurements are used to quantify the extent, dynamics and consequences of animal cell growth in mitosis and cytokinesis.
6. 1. Cell Biology
   2. Chromosomes and Gene Expression

   A ribosome assembly stress response regulates transcription to maintain proteome homeostasis

   Benjamin Albert et al.
7. 1. Chromosomes and Gene Expression

   Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity

   Jeffrey M Alexander et al.

   Sox2 transcription is not correlated with spatial proximity of its essential regulatory enhancer in embryonic stem cells, suggesting gene transcription is not limited to periods of direct enhancer-promoter contact.
8. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs

   Bert van de Kooij et al.
9. 1. Stem Cells and Regenerative Medicine

   Cell non-autonomous functions of S100a4 drive fibrotic tendon healing

   Jessica E Ackerman et al.
10. 1. Neuroscience

    Local online learning in recurrent networks with random feedback

    James M Murray