Latest research

1. 1. Microbiology and Infectious Disease

   Typhoid toxin sorting and exocytic transport from Salmonella Typhi-infected cells

   Shu-Jung Chang et al.

   A multidisciplinary approach provides a description of the exocytic pathway that exports Salmonella Typhi's typhoid toxin from infected cells.
2. 1. Immunology and Inflammation
   2. Structural Biology and Molecular Biophysics

   Structure of the IL-27 quaternary receptor signaling complex

   Nathanael A Caveney et al.

   The cryogenic-electron microscopy structure of IL-27 bound to receptors, IL-27Rα and gp130, revealing a three-site assembly mechanism and overall topology and molecular details reminiscent of IL-6 but distinct from related IL-12 and IL-23.
3. 1. Neuroscience

   A tonic nicotinic brake controls spike timing in striatal spiny projection neurons

   Lior Matityahu et al.

   A novel mechanism describes how tonic activation of nicotinic acetylcholine receptors can modulate the timing of striatal output by priming feedforward inhibition.
4. 1. Cell Biology
   2. Immunology and Inflammation

   A B-cell actomyosin arc network couples integrin co-stimulation to mechanical force-dependent immune synapse formation

   Jia C Wang et al.

   B-cell integrin co-stimulation promotes the formation of an actomyosin network that drives integrin-dependent immune synapse formation and B-cell activation.
5. 1. Evolutionary Biology
   2. Genetics and Genomics

   Radiocarbon and genomic evidence for the survival of Equus Sussemionus until the late Holocene

   Dawei Cai et al.

   The first nuclear genomes of the Equus (Sussemionus) ovodovi enable us to reconstruct the speciation and extinction trajectory of this lineage.
6. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells

   Le Xiong et al.

   Time-resolved multiomics analysis during Oct4 depletion and recovery reveals concentration-dependent activities of Oct4 in controlling enhancer transcription and chromatin accessibility in mouse embryonic stem cells.
7. 1. Neuroscience

   Higher-order olfactory neurons in the lateral horn support odor valence and odor identity coding in Drosophila

   Sudeshna Das Chakraborty et al.

   Two-photon functional imaging linked to olfactory preference in Drosophila provides the first understanding of how odors are integrated, transformed, and represented in the lateral horn by an ensemble of higher-order glutamatergic lateral horn neurons.
8. 1. Biochemistry and Chemical Biology

   Cytosolic aspartate aminotransferase moonlights as a ribosome binding modulator of Gcn2 activity during oxidative stress

   Robert A Crawford et al.
9. 1. Neuroscience

   Motor cortex activity across movement speeds is predicted by network-level strategies for generating muscle activity

   Shreya Saxena et al.
10. 1. Computational and Systems Biology
    2. Neuroscience

    Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson’s disease

    Timon Merk et al.

    Advanced machine learning based brain signal decoding of grip-force as a proxy for movement vigor shows Parkinson's disease related performance reduction, suggestive of a loss of cortical vigor encoding in the absence of dopamine.