Latest research

1. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor-targeting therapies

   Justin H Hwang et al.

   A comprehensive molecular interrogation of CREB5 interactions identified changes in protein and chromatin interactions of FOXA1 that promoted therapy resistance in prostate cancer cells.
2. 1. Cancer Biology
   2. Computational and Systems Biology

   Regulation of protein complex partners as a compensatory mechanism in aneuploid tumors

   Gökçe Senger et al.

   Coordinated regulation of co-complex members compensates for aneuploidy-induced stoichiometric imbalances in human cancer.
3. 1. Immunology and Inflammation
   2. Neuroscience

   Single-cell profiling reveals periventricular CD56^bright NK cell accumulation in multiple sclerosis

   Sabela Rodríguez-Lorenzo et al.

   Together, our multi-tissue single-cell data shows that CD56^bright NK cells accumulate in the periventricular brain regions of multiple sclerosis (MS) patients, bringing NK cells back to the spotlight of MS pathology.
4. 1. Cell Biology

   CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression

   Désirée Schatton et al.

   CLUH links growth signaling pathways and mitochondrial metabolism with cell cycle progression by regulating astrin-1 synthesis and stability.
5. 1. Neuroscience

   A dynamic clamp protocol to artificially modify cell capacitance

   Paul Pfeiffer et al.

   Via the capacitance clamp, electrophysiologists can for the first time flexibly set an artificial membrane capacitance for neurons and other excitable cells and thereby adjust their membrane time constant independent of any conductance changes.
6. 1. Neuroscience

   Eye movements reveal spatiotemporal dynamics of visually-informed planning in navigation

   Seren Zhu et al.

   The spatial and temporal patterns of eye movements exhibited by humans in virtual reality reveal how they plan paths when navigating in complex, naturalistic environments.
7. 1. Medicine
   2. Neuroscience

   Altered excitatory and inhibitory neuronal subpopulation parameters are distinctly associated with tau and amyloid in Alzheimer's disease

   Kamalini Ranasinghe et al.
8. 1. Immunology and Inflammation

   Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome

   Tadayoshi Karasawa et al.
9. 1. Structural Biology and Molecular Biophysics

   Deciphering a hexameric protein complex with Angstrom optical resolution

   Hisham Mazal et al.

   Cryogenic super-resolution microscopy resolves the three-dimensional arrangement of individual fluorescent markers attached to protein complexes with Angstrom precision through their blinking behavior, polarization selection and a classification scheme.
10. 1. Evolutionary Biology
    2. Genetics and Genomics

    Hybridization alters the shape of the genotypic fitness landscape, increasing access to novel fitness peaks during adaptive radiation

    Austin H Patton et al.

    Hybridization not only generates genetic diversity, but this diversity can alter the shape of the fitness landscape, changing which genotypic combinations are favored by natural selection and which accessible genotypic paths lead to novel fitness peaks.