Latest research

1. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Targeting mir128-3p alleviates myocardial insulin resistance and prevents ischemia-induced heart failure

   Andrea Ruiz-Velasco et al.

   Targeting mir128-3p could prevent cardiac insulin resistance in the non-infarcted myocardium and limit cardiac injury after myocardial infarction, delaying the development of heart failure.
2. 1. Neuroscience

   Cerebellar modulation of synaptic input to freezing-related neurons in the periaqueductal gray

   Christopher E Vaaga et al.

   The mouse cerebellum regulates innate defensive neural circuitry by tonically controlling dopamine release in the periaqueductal gray, thereby modulating synaptic responses of the Chx10-positive neurons that generate freezing behavior.
3. 1. Cell Biology
   2. Neuroscience

   Cell-specific exon methylation and CTCF binding in neurons regulate calcium ion channel splicing and function

   Eduardo Javier López Soto, Diane Lipscombe

   Cell-specific alternative splicing of the synaptic calcium channel gene Cacna1b is controlled by exon hypomethylation and CTCF binding and is disrupted following nerve injury.
4. 1. Cell Biology
   2. Developmental Biology

   Super-resolution microscopy reveals coupling between mammalian centriole subdistal appendages and distal appendages

   Weng Man Chong et al.
5. 1. Neuroscience

   KIT ligand protects against both light-induced and genetic photoreceptor degeneration

   Huirong Li et al.
6. 1. Cell Biology
   2. Physics of Living Systems

   Microneedle manipulation of the mammalian spindle reveals specialized, short-lived reinforcement near chromosomes

   Pooja Suresh et al.

   Directly exerting force on the mammalian spindle reveals local and short-lived reinforcement in the spindle center, well-suited to preserve connections to chromosomes over seconds and yet allow remodeling over minutes.
7. 1. Neuroscience

   Kainate receptors regulate development of glutamatergic synaptic circuitry in the rodent amygdala

   Maria Ryazantseva et al.

   Glutamatergic projections from basolateral to central amygdala, implicated in neuropsychiatric disorders, develop rapidly during early postnatal period and their development is modulated via endogenously active kainate receptors.
8. 1. Biochemistry and Chemical Biology
   2. Immunology and Inflammation

   A loop structure allows TAPBPR to exert its dual function as MHC I chaperone and peptide editor

   Lina Sagert et al.

   A dedicated structural element facilitates chaperone and antigenic peptide selector function of TAP-associated glycoprotein, a major quality assurance auditor in adaptive immunity.
9. 1. Neuroscience

   Whole brain delivery of an instability-prone Mecp2 transgene improves behavioral and molecular pathological defects in mouse models of Rett syndrome

   Mirko Luoni et al.

   Global brain transduction of the instability-prone Mecp2 transgene by systemic AAV-PHP.eB administration is safe and effective in protecting male and female Mecp2 mutant mice from the Rett syndrome disease phenotype.
10. 1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Cell-type diversity and regionalized gene expression in the planarian intestine

    David J Forsthoefel et al.

    Application of laser-capture microdissection to planarian intestinal tissue provides a new tool for analysis of tissue-specific gene expression in flatworms, and a new resource to advance investigations of gastrointestinal regeneration.