Latest research

1. 1. Chromosomes and Gene Expression
   2. Evolutionary Biology

   Dynamic turnover of centromeres drives karyotype evolution in Drosophila

   Ryan Bracewell et al.

   De novo formation of centromeres creates diverse karyotypes in flies and is accompanied by rapid turnover of centromere-associated satellite repeats.
2. 1. Cell Biology
   2. Chromosomes and Gene Expression

   H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis

   Andrey Poleshko et al.

   The histone modification H3K9me2 marks peripheral heterochromatin and ensures positional information is safeguarded through cell division such that individual lamina-associated domains are re-established at the nuclear periphery in daughter nuclei.
3. 1. Computational and Systems Biology
   2. Stem Cells and Regenerative Medicine

   Self-assembling manifolds in single-cell RNA sequencing data

   Alexander J Tarashansky et al.

   An iterative self-assembling algorithm identifies the intrinsic structures in single-cell transcriptomic data and helps to discover new cell populations that are undetectable by existing methods.
4. 1. Cell Biology
   2. Developmental Biology

   Matrix metalloproteinase 1 modulates invasive behavior of tracheal branches during entry into Drosophila flight muscles

   Julia Sauerwald et al.

   Tracheal-derived matrix metalloproteinase 1 activity sustains tracheal branch invasion into myotubes by modulating ECM properties and dynamic behavior of sprouting tip cells.
5. 1. Neuroscience

   A statistical framework to assess cross-frequency coupling while accounting for confounding analysis effects

   Jessica K Nadalin et al.
6. 1. Computational and Systems Biology
   2. Neuroscience

   Rats exhibit similar biases in foraging and intertemporal choice tasks

   Gary A Kane et al.

   In both foraging and intertemporal choice tasks, rats prefer immediate rewards to delayed rewards, and this preference can be explained by a form of hyperbolic discounting.
7. 1. Structural Biology and Molecular Biophysics

   Molecular mechanism of TRPV2 channel modulation by cannabidiol

   Ruth A Pumroy et al.

   Cannabidiol binds to TRPV2 via a previously unidentified, but highly conserved, pocket.
8. 1. Evolutionary Biology

   Fog signaling has diverse roles in epithelial morphogenesis in insects

   Matthew Alan Benton et al.

   Fog signaling with a narrow morphogenetic role in Drosophila has a deeply conserved function in epithelial morphogenesis across insects.
9. 1. Cell Biology

   Regulated spindle orientation buffers tissue growth in the epidermis

   Angel Morrow et al.

   The epidermis uses regulated spindle orientation to maintain robust homeostasis in response to perturbations in proliferation or differentiation.
10. 1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Bacterial survival in microscopic surface wetness

    Maor Grinberg et al.