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Endocannabinoid signaling enhances visual responses through modulation of intracellular chloride levels in retinal ganglion cells

Endocannabinoid activation of the CB1 receptor on retinal ganglion cells in the eye results in enhanced excitability and responsiveness to visual stimulation through a novel mechanism involving intracellular chloride regulation.
  • Loïs S Miraucourt
  • Jennifer Tsui
  • Delphine Gobert
  • Jean-François Desjardins
  • Anne Schohl
  • Mari Sild
  • Perry Spratt
  • Annie Castonguay
  • Yves De Koninck
  • Nicholas Marsh-Armstrong
  • Paul W Wiseman
  • Edward S Ruthazer
10.7554/eLife.15932
Research Article Neuroscience
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Mesencephalic representations of recent experience influence decision making

Activity in the pedunculopontine tegmental nucleus reflects the choices and outcomes of previous trials in a decision making task, and affects upcoming choices.
  • John A Thompson
  • Jamie D Costabile
  • Gidon Felsen
10.7554/eLife.16572
Research Article Neuroscience
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Dopaminergic neurons write and update memories with cell-type-specific rules

Building on previous work (Aso et al., 2014a; Aso et al., 2014b), cell-type-specific drivers and optogenetics are used to control the local release of dopamine and reveal that distinct learning rules are implemented in parallel memory units.
  • Yoshinori Aso
  • Gerald M Rubin
10.7554/eLife.16135
Research Advance Neuroscience
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Distinct roles of visual, parietal, and frontal motor cortices in memory-guided sensorimotor decisions

Visual, parietal, and frontal motor cortices play distinct and necessary roles in mapping sensory features to future motor action.
  • Michael J Goard
  • Gerald N Pho
  • Jonathan Woodson
  • Mriganka Sur
10.7554/eLife.13764
Research Article Neuroscience
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Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1

Post-translational processing of the SKN-1A/Nrf1 transcription factor regulates proteasome expression.
  • Nicolas J Lehrbach
  • Gary Ruvkun
10.7554/eLife.17721
Research Article Cell Biology Developmental Biology and Stem Cells
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BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer

Strengthening of spindle assembly checkpoint activity and attachment error correction through BubR1 manipulation preserves genomic integrity and protects against tumor formation.
  • Robbyn L Weaver
  • Jazeel F Limzerwala
  • Ryan M Naylor
  • Karthik B Jeganathan
  • Darren J Baker
  • Jan M van Deursen
10.7554/eLife.16620
Research Article Cancer Biology Genes and Chromosomes
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Opposing roles for DNA replication initiator proteins ORC1 and CDC6 in control of Cyclin E gene transcription

Two related DNA replication initiation proteins contribute to the decision of whether to enter a new round of the cell division cycle or enter into a period of proliferative quiescence.
  • Manzar Hossain
  • Bruce Stillman
10.7554/eLife.12785
Research Article Biochemistry Genes and Chromosomes
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PTRF/Cavin-1 promotes efficient ribosomal RNA transcription in response to metabolic challenges

PTRF (Cavin-1) mediates metabolism-regulated ribosomal transcription in mature adipocytes, independent of its role in caveolae formation.
  • Libin Liu
  • Paul F Pilch
10.7554/eLife.17508
Research Article Biochemistry Cell Biology
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Visual landmarks sharpen grid cell metric and confer context specificity to neurons of the medial entorhinal cortex

The firing rate of MEC neurons conveys information about visual landmarks.
  • José Antonio Pérez-Escobar
  • Olga Kornienko
  • Patrick Latuske
  • Laura Kohler
  • Kevin Allen
10.7554/eLife.16937
Research Article Neuroscience
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Circadian RNA expression elicited by 3’-UTR IRAlu-paraspeckle associated elements

Circadian gene expression can be driven by a post-transcriptional mechanism involving circadian mRNA nuclear retention by paraspeckle nuclear bodies.
  • Manon Torres
  • Denis Becquet
  • Marie-Pierre Blanchard
  • Séverine Guillen
  • Bénédicte Boyer
  • Mathias Moreno
  • Jean-Louis Franc
  • Anne-Marie François-Bellan
10.7554/eLife.14837
Research Article Cell Biology Genes and Chromosomes
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