Latest research

1. 1. Neuroscience

   In vivo imaging with a water immersion objective affects brain temperature, blood flow and oxygenation

   Morgane Roche et al.

   Brain temperature and oxygenation vary according to the imaging conditions during two-photon microscopy.
2. 1. Neuroscience

   Chronically implanted Neuropixels probes enable high-yield recordings in freely moving mice

   Ashley L Juavinett et al.

   A new device enables researchers to use and recycle extracellular electrodes (e.g. Neuropixels) for high-yield recordings during freely moving mouse experiments.
3. 1. Immunology and Inflammation

   Multiplexed imaging of immune cells in staged multiple sclerosis lesions by mass cytometry

   Valeria Ramaglia et al.

   Imaging mass cytometry simultaneously lights up distinct immune cells in the brain.
4. 1. Evolutionary Biology

   Rapid decline of bacterial drug-resistance in an antibiotic-free environment through phenotypic reversion

   Anett Dunai et al.

   Drug-resistance declines in the laboratory in an antibiotic stress-free environment, indicating that restricting antimicrobial usage in the clinics could be a useful policy.
5. 1. Neuroscience

   Mapping the human subcortical auditory system using histology, postmortem MRI and in vivo MRI at 7T

   Kevin R Sitek et al.

   MRI methods are promising techniques for investigating the human subcortical auditory system, and these publicly available data, atlases, and tools make researching human audition simpler and more reliable.
6. 1. Neuroscience

   Statistical learning attenuates visual activity only for attended stimuli

   David Richter, Floris P de Lange
7. 1. Developmental Biology

   Two-step regulation of trachealess ensures tight coupling of cell fate with morphogenesis in the Drosophila trachea

   Takefumi Kondo, Shigeo Hayashi

   The Drosophila tracheal fate is stabilized by the combination of transcriptional programs to control tissue architecture and tissue-level input sensitive to tubular geometry, ensuring the robust mechanism of organ determination.
8. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Stochastic cell-cycle entry and cell-state-dependent fate outputs of injury-reactivated tectal radial glia in zebrafish

   Shuguang Yu, Jie He

   The analysis of injury-reactivated tectal radial glia in zebrafish reveals a stochastic cell-cycle entry and cell-state-dependent regulation of the balance between neurogenesis and gliogenesis.
9. 1. Structural Biology and Molecular Biophysics

   Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain

   Zhicheng Zuo et al.

   The catalytic activation of the Cas9 HNH domain involves a unique conformational change in the ββα-metal motif that is collectively driven by the interactions with the metal ions and DNA.
10. 1. Cell Biology

    Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk

    Olga Afonso et al.

    Quantitative live-cell microscopy and molecular perturbations in Drosophila and human cells reveal a crosstalk between molecular 'rulers' (Aurora B) and 'clocks' (Cdk1) that coordinates mitotic exit in space and time.