All research categories

Highlights

  • Enhancing the Cre-loxP system

    Two new genetic tools – roxCre and loxCre – can improve the performance of the Cre-loxP system for making genetic modifications in vivo.

    Mengyang Shi, Jie Li ... Bin Zhou
    Reviewed Preprint Updated

  • Cell mechanics and metastasis

    The discovery of a pro-invasive mechanotransduction pathway driven by cell crowding suggests that an ion channel called TRPV4 may be a promising therapeutic target for inhibiting metastasis.

    Xiangning Bu, Nathanael Ashby ... Inhee Chung
    Reviewed Preprint Updated

  • Science Under Threat in the US

    The new administration in the US is conducting an assault on science and scientists – how should the scientific community respond?

    Collection

Latest research

    1. Cell Biology
    2. Genetics and Genomics

    Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for Glaucoma

    Keva Li, Nicholas Tolman ... UK Biobank Eye and Vision Consortium
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Identification of novel microcephaly-linked protein ABBA that mediates cortical progenitor cell division and corticogenesis through NEDD9-RhoA

    Aurelie Carabalona, Henna Kallo ... Claudio Rivera
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Developmental Biology

    Numb provides a fail-safe mechanism for intestinal stem cell self-renewal in adult Drosophila midgut

    Mengjie Li, Aiguo Tian, Jin Jiang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Evolutionary Biology

    Fast evolutionary turnover and overlapping variances of sex-biased gene expression patterns defy a simple binary classification of sexes

    Chen Xie, Sven Künzel, Diethard Tautz
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    Olfactory combinatorial coding supports risk-reward decision making in C. elegans

    Md Zubayer Hossain Saad, William G Ryan ... Bruce A Bamber
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Evolutionary Biology

    Evidence for deliberate burial of the dead by Homo naledi

    Lee R Berger, Tebogo Makhubela ... John Hawks
    Revised
    Reviewed Preprint v2
    Updated
    • Landmark
    • Convincing
    • Incomplete
    1. Neuroscience

    Electrophysiology and morphology of human cortical supragranular pyramidal cells in a wide age range

    Pál Barzó, Ildikó Szöts ... Gábor Tamás
    Multimodal analysis of human cortical excitatory neurons reveals age-dependent differences.
    1. Immunology and Inflammation
    2. Medicine

    Deciphering the preeclampsia-specific immune microenvironment and the role of pro-inflammatory macrophages at the maternal–fetal interface

    Haiyi Fei, Xiaowen Lu ... Lingling Jiang
    Multi-omics analysis shows that preeclampsia-specific immune cell network was regulated by Folr2+Ccl7+Ccl8+C1qa+C1qb+C1qc+ pro-inflammatory macrophages, which can induce the CD8+ and Th17 memory T cells generation while inhibiting the gMDSCs production.
    1. Neuroscience

    A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following status epilepticus in mice

    Lotfi Ferhat, Rabia Soussi ... Michel Khrestchatisky
    Pharmacologically induced hypothermia elicits anticonvulsant, neuroprotective, and anti-inflammatory properties.
    1. Stem Cells and Regenerative Medicine

    Compositional editing of extracellular matrices by CRISPR/Cas9 engineering of human mesenchymal stem cell lines

    Sujeethkumar Prithiviraj, Alejandro Garcia Garcia ... Paul E Bourgine
    Human extracellular matrices can be edited in their composition using the CRISPR/Cas9 system, leading to materials exhibiting tailored regenerative capacities.
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Magazine

  1. Science Under Threat in the United States: How to make science more efficient

    Stuart Buck
    1. Neuroscience

    Memory: Integrating past experiences

    Thomas MW Leir, Matthew PH Gardner

  3. Science Under Threat in the United States: Campaigning for science and scientists

    Adriana Bankston
  4. Scientists at a Stand Up For Science rally

    Science Under Threat in the US

    Edited by Peter A Rodgers

  5. Science Under Threat in the United States: The impact on undergraduate students

    Reenie Tian, Kamna Kalkunte ... Mayank Chugh

  6. Science Under Threat in the United States: Research turns hope into reality

    Anna C Greene, Casey S Greene

  7. Science Under Threat in the United States: How scientists and institutions should respond

    Ran Blekhman
  8. See more Magazine articles

Research categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
  16. Plant Biology
  17. Stem Cells and Regenerative Medicine
  18. Structural Biology and Molecular Biophysics
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