Latest research

1. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation

   Xiao-Tong Lin et al.

   Using IGF2BP1-PLK1 axis as an example, targeting oncogenic signaling represents a direction treatment for HCC patients with high FBXO45 expression.
2. 1. Neuroscience

   Maturation of persistent and hyperpolarization-activated inward currents shapes the differential activation of motoneuron subtypes during postnatal development

   Simon A Sharples, Gareth B Miles

   Electrophysiological recordings from mouse spinal motoneurons reveal key roles for ion channels in establishing the differential activation of motoneuron subtypes during postnatal development.
3. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Type 1 polyisoprenoid diphosphate phosphatase modulates geranylgeranyl-mediated control of HMG CoA reductase and UBIAD1

   Rania Elsabrouty et al.

   Type 1 polyisoprenoid diphosphate phosphatase (PDP1) contributes to interconversion of isoprenols and isoprenylpyrophosphates, balancing the sterol and nonsterol branches of the mevalonate pathway by regulating ERAD of HMG CoA reductase and ER-to-Golgi transport of UBIAD1.
4. 1. Immunology and Inflammation
   2. Structural Biology and Molecular Biophysics

   Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality

   Mohamed A Badawy et al.

   Electron paramagnetic resonance spectroscopy quantitatively correlates structural damages of serum albumin with COVID-19 severity and mortality thus suggesting albumin replacement therapy as a strategy to rescue patients at risk of mortality.
5. 1. Neuroscience

   Population receptive fields in nonhuman primates from whole-brain fMRI and large-scale neurophysiology in visual cortex

   P Christiaan Klink et al.

   Within-species comparison of population receptive fields determined with fMRI and electrophysiology in nonhuman primates reveals the neuronal basis of blood-oxygen-level-dependent-based retinotopy.
6. 1. Developmental Biology
   2. Neuroscience

   Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods

   Eduardo Loureiro-Campos et al.
7. 1. Developmental Biology
   2. Neuroscience

   CRMP4-mediated fornix development involves semaphorin-3E signaling pathway

   Benoît Boulan et al.
8. 1. Cell Biology
   2. Microbiology and Infectious Disease

   Toxoplasma bradyzoites exhibit physiological plasticity of calcium and energy stores controlling motility and egress

   Yong Fu et al.
9. 1. Neuroscience

   Taste sensing and sugar detection mechanisms in Drosophila larval primary taste center

   G Larisa Maier et al.
10. 1. Neuroscience

    Working memory capacity of crows and monkeys arises from similar neuronal computations

    Lukas Alexander Hahn et al.