Latest research

1. 1. Cell Biology
   2. Genes and Chromosomes

   Post-meiotic DNA double-strand breaks occur in Tetrahymena, and require Topoisomerase II and Spo11

   Takahiko Akematsu et al.

   The first genetic compelling evidence for post-meiotic DNA double-strand breaks and its relation to chromatin remodeling in haploid pronuclei is shown.
2. 1. Biophysics and Structural Biology
   2. Cell Biology

   9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments

   Svetlana O Dodonova et al.

   A molecular model of the assembled COPI coat, determined by cryo-electron tomography of an in vitro reconstituted budding reaction, reveals details of interactions mediating coat assembly and shows the binding site of ArfGAP2.
3. 1. Epidemiology and Global Health
   2. Genomics and Evolutionary Biology

   The Anopheles gambiae 2La chromosome inversion is associated with susceptibility to Plasmodium falciparum in Africa

   Michelle M Riehle et al.

   A common chromosome inversion in African malaria mosquito (Anopheles gambiae) is associated with differences in malaria infection, adult resting behavior and ecology, and may aid the most efficient vectors to evade malaria control.
4. 1. Genomics and Evolutionary Biology
   2. Microbiology and Infectious Disease

   Exploiting CRISPR-Cas to manipulate Enterococcus faecalis populations

   Karthik Hullahalli et al.
5. 1. Genomics and Evolutionary Biology
   2. Microbiology and Infectious Disease

   Extensive horizontal gene transfer in cheese-associated bacteria

   Kevin S Bonham et al.
6. 1. Cancer Biology
   2. Cell Biology

   MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect

   Charles DeRossi et al.
7. 1. Genomics and Evolutionary Biology

   On the mechanistic nature of epistasis in a canonical cis-regulatory element

   Mato Lagator et al

   Thermodynamic framework accurately predicts the sign of epistasis and its environment dependence for a canonical cis-regulatory element.
8. 1. Neuroscience

   MeCP2 regulates Tet1-catalyzed demethylation, CTCF binding, and learning-dependent alternative splicing of the BDNF gene in Turtle

   Zhaoqing Zheng et al

   Loss of MeCP2 function negatively impacts Tet1 and CTCF binding thereby negatively impacting learning-dependent DNA methylation and alternative splicing regulation.
9. 1. Developmental Biology and Stem Cells
   2. Neuroscience

   Genetic specification of left–right asymmetry in the diaphragm muscles and their motor innervation

   Camille Charoy et al

   Analysis of embryonic mouse diaphragm reveals muscle and nerve left–right asymmetries set by a Nodal-dependent genetic cascade, which imprints different molecular signatures to left and right motoneurons that shape their innervation pattern.
10. 1. Developmental Biology and Stem Cells

    A pilot study of large-scale production of mutant pigs by ENU mutagenesis

    Tang Hai et al