Latest research

1. 1. Cell Biology
   2. Developmental Biology

   The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos

   Sophie M Morgani et al.

   Loss of the transcription factor Rreb1 results perturbs epithelial architecture during mouse development resulting in invasive cell behaviors, severe cardiovascular defects, and embryonic lethality.
2. 1. Microbiology and Infectious Disease

   Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation

   Mart M Lamers et al.

   Cell culture adaptation of SARS-CoV-2 is prevented on human airway cells with an active serine protease-mediated entry pathway, allowing the production of genetically stable virus stocks for laboratory experiments.
3. 1. Evolutionary Biology

   Multi-step vs. single-step resistance evolution under different drugs, pharmacokinetics and treatment regimens

   Claudia Igler et al.
4. 1. Cell Biology
   2. Medicine

   Polymerization of misfolded Z alpha-1antitrypin protein lowers CX3CR1 expression in human PBMCs

   Srinu Tumpara et al.
5. 1. Genetics and Genomics
   2. Neuroscience

   Integrated transcriptomic and neuroimaging brain model decodes biological mechanisms in aging and Alzheimer’s disease

   Quadri Adewale et al.

   Identification of causal genes and their effects on other biological determinants untangles the complexities of aging and Alzheimer's and can facilitate drug discovery for sustaining healthy aging and treating Alzheimer's.
6. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Random sub-diffusion and capture of genes by the nuclear pore reduces dynamics and coordinates interchromosomal movement

   Michael Chas Sumner et al.
7. 1. Epidemiology and Global Health

   Modeling the impact of racial and ethnic disparities on COVID-19 epidemic dynamics

   Kevin C Ma et al.
8. 1. Neuroscience

   Local circuit allowing hypothalamic control of hippocampal area CA2 activity and consequences for CA1

   Vincent Robert et al.
9. 1. Developmental Biology
   2. Neuroscience

   R7 photoreceptor axon targeting depends on the relative levels of lost and found expression in R7 and its synaptic partners

   Jessica Douthit et al.
10. 1. Neuroscience

    ß2-Arrestin germline knockout does not attenuate opioid respiratory depression

    Iris Bachmutsky et al.