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Latest research

    1. Developmental Biology

    Distinct responses to rare codons in select Drosophila tissues

    Scott R Allen et al.
    A tissue-wide fluoresence-based screen reveals that not all tissues in an organism (Drosophila) reinforce a hierarchy of codon usage to the same extent, a finding which impacts tissue-specific protein expression and function.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    A transcriptomic atlas of Aedes aegypti reveals detailed functional organization of major body parts and gut regional specializations in sugar-fed and blood-fed adult females

    Bretta Hixson et al.
    RNAseq profiles of female Aedes body parts, gut regions, and blood-fed guts provide insight into the anatomical patterning of immune and digestive function, and demonstrate the sequential induction of multiple peptidase cohorts over the course of blood meal digestion.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Role of oxidation of excitation-contraction coupling machinery in age-dependent loss of muscle function in Caenorhabditis elegans

    Haikel Dridi et al.
    The Ryanodine receptor type 1 calcium channels play a critical role in age-related muscle function loss.
    1. Biochemistry and Chemical Biology

    Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry

    Tiantian Wei et al.
    A potent and selective DYRK2 inhibitor has been developed and used as a chemical tool to reveal eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) and stromal interaction molecule 1 (STIM1) are new substrates for DYRK2.
    1. Medicine
    2. Physics of Living Systems

    Synchronization in renal microcirculation unveiled with high-resolution blood flow imaging

    Dmitry Postnov et al.
    High-resolution blood flow imaging confirms the presence of large, long-living synchronous clusters in renal microcirculation and reveals how vasoactive drugs affect synchronization properties.
    1. Neuroscience

    Prefrontal-amygdalar oscillations related to social behavior in mice

    Nahoko Kuga et al.
    The dorsal medial prefrontal cortex and basolateral amygdala exhibit social behavior-relevant neuronal oscillations, representing unified pathophysiological mechanisms underlying social behavioral deficits.
    1. Neuroscience

    Non-rapid eye movement sleep and wake neurophysiology in schizophrenia

    Nataliia Kozhemiako et al.
    Multiple non-redundant features of non-rapid eye movement sleep are altered in schizophrenia and largely independent of waking electrophysiological abnormalities, supporting the promise of neuropsychiatric disease biomarkers based on a precise dissection of the sleep.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Comparative multi-tissue profiling reveals extensive tissue-specificity in transcriptome reprogramming during thermal adaptation

    Noushin Hadadi et al.
    Integrative analysis of multi-tissue transcriptomics data of mice subjected to cold, mild warm or room temperature places the thermal adaptation of individual tissues in a whole-organism perspective.