Latest research

1. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways

   Spencer Hill et al.

   Human cullin-RING ligases are buffered to a much greater extent than had been previously appreciated, and the roles of ubiquitin chain extension enzymes are far more nuanced at physiological concentrations.
2. 1. Human Biology and Medicine
   2. Neuroscience

   Human Neocortical Neurosolver (HNN), a new software tool for interpreting the cellular and network origin of human MEG/EEG data

   Samuel A Neymotin et al.
3. 1. Cell Biology
   2. Developmental Biology

   Stepwise polarisation of developing bilayered epidermis is mediated by aPKC and E-cadherin in zebrafish

   Prateek Arora et al.

   Polarity cascade initiated by aPKC in the periderm is transduced by adherens junction component E-cadherin to the basal epidermis during the development of zebrafish bilayered epidermis.
4. 1. Microbiology and Infectious Disease

   Single cell analysis reveals human cytomegalovirus drives latently infected cells towards an anergic-like monocyte state

   Miri Shnayder et al.
5. 1. Cell Biology
   2. Microbiology and Infectious Disease

   Cryo electron tomography with volta phase plate reveals novel structural foundations of the 96-nm axonemal repeat in the pathogen Trypanosoma brucei

   Simon Imhof et al.

   Cryo electron tomography provides the first high-resolution 3D axoneme structure from any pathogenic organism, revealing novel structures that support the unique motility of these pathogens through host tissues.
6. 1. Neuroscience

   Relaxation of synaptic inhibitory events as a compensatory mechanism in fetal SOD spinal motor networks

   Pascal Branchereau et al.

   Electrophysiological and simulation approaches show that a chloride-related longer relaxation of the inhibitory synaptic events partially compensates the early defect in the chloride homeostasis detected in fetal SOD spinal motoneurons.
7. 1. Neuroscience

   High and asymmetric somato-dendritic coupling of V1 layer 5 neurons independent of visual stimulation and locomotion

   Valerio Francioni et al.

   Layer 5 neuron apical tuft in mouse visual cortex display widespread, highly correlated calcium signals, with a strong and asymmetric coupling to somatic signals, independent of visual stimulation and locomotion.
8. 1. Neuroscience

   Catecholaminergic modulation of meta-learning

   Jennifer L Cook et al.

   A human psychopharmacology study reveals that a drug that affects the dopamine and noradrenaline systems enhances people's ability to adapt their learning rate to suit the volatility of the environment.
9. 1. Cell Biology
   2. Physics of Living Systems

   Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice

   Kaushikaram Subramanian et al.

   Establishing retinal contrast transmission as a novel determinant of mammalian fitness, this research adds functional significance to a prominent exception of nuclear organization, previously described in nocturnal rod photoreceptor cells.
10. 1. Ecology

    Substantial near-infrared radiation-driven photosynthesis of chlorophyll f-containing cyanobacteria in a natural habitat

    Michael Kühl et al.

    Cyanobacteria with chlorophyll f show substantial near-infrared radiation-driven photosynthesis and can play an important role for primary production in endolithic, intertidal habitats.