Highlights

  • Bruce-mediated growth control

    Genetic, proteomic, and structural modelling techniques highlight the role of the protein Bruce in restraining Drosophila wing growth.

    Natsuki Shinoda, Yutaro Hama ... Masayuki Miura
    Research Article

  • Replication in Drosophila studies

    An analysis of 400 articles on the immune response in Drosophila highlights a need for caution regarding the replicability of certain claims.

    Hannah Westlake, Fabrice David ... Bruno Lemaitre
    Reviewed Preprint Updated

  • Tsetse fly feeding adaptations

    Investigations into the biomechanics of tsetse fly blood feeding reveal that subtle anatomical adaptations enable the penetration of a diverse range of host hides.

    Stephan Löwe, Laura Hauf ... Markus Engstler
    Research Article

  • Neurosecretory connections

    Connectomic and transcriptomic analyses reveal the anatomical and functional organisation of neurosecretion in the Drosophila brain.

    Theresa H McKim, Jayati Gera ... Meet Zandawala
    Research Article

  • AI in research communication

    eLife has partnered on a number of projects harnessing AI for improving human and machine reader engagement with research.

    Inside eLife

  • Explore our new collection

    Delve into leading research on Lifestyle, Environment and Epigenetic Inheritance.

    Collection
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Biochemistry and Chemical Biology

    Glycolipid MPIase is essential for the TAT (twin-arginine translocation) pathway

    Hanako Nishikawa, Nachi Yamamoto ... Ken-ichi Nishiyama
    The glycolipid MPIase acts as a receptor of twin-arginine translocation (TAT) signals, inserts them into membranes, and potentially modulates the TatABC structure to facilitate TAT translocation.
    1. Neuroscience

    Behavioural and neurogenetic evidence for emotion primitives in the fruit fly Drosophila from an open field test

    Yi Lueningschroer-Wang, Emilia Derksen ... Christian Wegener
    Wall-following and total walking activity in a behavioural assay can serve as indicators of emotional valence and arousal and provide evidence for the presence of emotion primitives in fruit flies.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Quantifying microbial fitness in high-throughput experiments

    Justus Wilhelm Fink, Michael Manhart
    The choice of fitness metric is crucial in microbial ecology—commonly chosen metrics lead to different results that may affect the conclusions from pairwise competition assays and high-throughput genetic screens.
    1. Neuroscience

    Psilocybin asymmetrically modulates outcome-based choice and cortical processing under uncertainty

    David Jacobs, Alejandro Torrado Pacheco ... Bita Moghaddam
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    WNK-SPAK/OSR1 signaling pathway facilitates ictal activity via reduced neuronal chloride extrusion rate

    Volodymyr I Dzhala, Fu Hung Shiu ... Kevin J Staley
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Preferential formation of NUP98::KDM5A condensates at specific H3K4me3-rich loci drives leukemogenic gene expression

    Augusto Berrocal, Jonathan E Sandoval ... Bo Huang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    A neural mechanism for compositional structure transfer in humans

    Lennart Luettgau, Nan Chen ... Raymond J Dolan
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Glutamate receptor composition at Drosophila neuromuscular junctions depends on developmental stage and muscle identity

    Anne Sustar, Chengjie Qiu ... John C Tuthill
    Diverse combinations of glutamate receptor subunits are expressed across developmental stages and even between adjacent muscles in adult Drosophila.
    1. Neuroscience

    Oxytocin neurons signal state-dependent transitions from rest to thermogenesis and behavioral arousal

    Morgane Vandendoren, Jason G Landen ... Adam Nelson
    Oxytocin neurons couple physiological warming to behavioral arousal, revealing a homeostatic mechanism that coordinates transitions between low- and high-energy states.
    1. Neuroscience

    Compensation of hyperexcitability with simulation-based inference

    Daniel Müller-Komorowska, Tomoki Fukai
    Simulation-based inference predicts putative circuit mechanisms of hyperexcitability in a phenomenological microcircuit simulator with more than 30 free intrinsic and synaptic parameters.
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Magazine

    1. Cell Biology
    2. Physiology

    Mechanosensory Physiology: Lymphatic vessels under pressure

    Asser F Bedair, Osama F Harraz
    1. Epidemiology and Global Health

    Science Forum: The new paradox of women’s health research

    Ursula Debarnot, Alexandre Fouré
    1. Genetics and Genomics
    2. Physiology

    Steroid Signaling: A hormonal message for a longer life

    Kyle Feola, Peter M Douglas
    1. Microbiology and Infectious Disease

    Bird Flu: The cow udder as an influenza mixing ground

    Silke Rimaux, Robert P de Vries
    1. Computational and Systems Biology

    AI in Science: The 42 problem in AI-assisted research

    Giovanni Spitale, Federico Germani
    1. Genetics and Genomics
    2. Developmental Biology
    grid of multicoloured bar graphs with vertical shaded areas in red and green highlighting specific columns

    Lifestyle, Environment and Epigenetic Inheritance: A Collection of Articles

    Edited by Wei Yan

  7. Research Culture: From East to West – an early-career researcher’s voyage across continents

    Samuel C Eziuzor
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
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  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
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  9. Evolutionary Biology
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  12. Medicine
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