Latest research

1. 1. Immunology and Inflammation

   Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature

   Chao Yang et al.

   T-bet suppresses the expression of immature NK cell-defining genes.
2. 1. Neuroscience
   2. Structural Biology and Molecular Biophysics

   Disease-associated mutations in the human TRPM3 render the channel overactive via two distinct mechanisms

   Siyuan Zhao et al.

   Disease-associated mutants of the TRPM3 ion channel are overactive, and they are inhibited by the antiepileptic medication primidone, offering a potential therapeutic intervention to treat this channelopathy.
3. 1. Neuroscience

   Principles of operation of a cerebellar learning circuit

   David J Herzfeld et al.

   Quantitative analysis of behavior coupled with computational modeling reveal the set of circuit-level principles that underlie cerebellar-dependent motor learning in smooth pursuit eye movements of monkeys across timescales.
4. 1. Chromosomes and Gene Expression

   A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans

   Kevin I Manage et al.

   SIMR-1 acts downstream of the piRNA pathway to promote siRNA amplification by the Mutator complex and localizes to perinuclear foci distinct from Mutator foci, P granules and Z granules.
5. 1. Neuroscience

   Effects of fluorescent glutamate indicators on neurotransmitter diffusion and uptake

   Moritz Armbruster et al.

   Fluorescent glutamate indicators distort the time course of neurotransmitter diffusion and uptake by competing with transporters, an important caveat to consider when using iGluSnFR and its analogs.
6. 1. Evolutionary Biology
   2. Neuroscience

   True S-cones are concentrated in the ventral mouse retina and wired for color detection in the upper visual field

   Francisco M Nadal-Nicolás et al.
7. 1. Cell Biology
   2. Neuroscience

   Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses

   Kirby M Donnelly et al.
8. 1. Neuroscience

   Apical length governs computational diversity of layer 5 pyramidal neurons

   Alessandro R Galloni et al.
9. 1. Cancer Biology
   2. Computational and Systems Biology

   Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions

   Christopher J Lord et al.
10. 1. Biochemistry and Chemical Biology

    Genomic innovation of ATD alleviates mistranslation associated with multicellularity in Animalia

    Santosh Kumar Kuncha et al.