Microscopy versus malaria

Latest research

1. 1. Cell Biology

   Differential regulation of hair cell actin cytoskeleton mediated by SRF and MRTFB

   Ling-Yun Zhou, Chen-Xi Jin ... Hao Wu

   In hair cells, the development and maintenance of the F-actin-enriched stereocilia and cuticular plates are differentially regulated by transcription factors SRF and MRTFB, and SRF–CNN2 is required for modulating actin dynamics of the stereocilia and cuticular plate.
2. 1. Neuroscience

   Multiple NTS neuron populations cumulatively suppress food intake

   Weiwei Qui, Chelsea R Hutch ... Darleen Sandoval
3. 1. Neuroscience

   Postsynaptic mitochondria are positioned to support functional diversity of dendritic spines

   Connon I Thomas, Melissa A Ryan ... Benjamin Scholl

   Correlated light and electron microscopy of cortical neurons reveals a local organization of mitochondria near dendritic spines with diverse functional properties.
4. 1. Evolutionary Biology
   2. Genetics and Genomics

   A timeline of bacterial and archaeal diversification in the ocean

   Carolina A Martinez-Gutierrez, Josef C Uyeda, Frank O Aylward

   Phylogenomics reveals the timeline over which marine bacteria and archaea colonized the oceans and shows the geological context of their diversification.
5. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to antifungal compounds

   Vanessa Dumeaux, Samira Massahi ... Michael T Hallett

   Candida albicans cells respond in two distinct ways to fluconazole exposure where cells enter the Ribo-dominant state characterized by an upregulation of ribosomal-related proteins and processes, or cells enter the Stress-dominant state characterized by the upregulation of stress responses.
6. 1. Evolutionary Biology
   2. Genetics and Genomics

   Down the Penrose stairs, or how selection for fewer recombination hotspots maintains their existence

   Zachary Baker, Molly Przeworski, Guy Sella

   Modeling the evolution of PRDM9 in light of recent results implicating the importance of PRDM9 binding symmetry suggests the advantage of new PRMD9 alleles is in limiting the number of binding sites used effectively rather than increasing net binding.
7. 1. Immunology and Inflammation

   Pulsed ultrasound promotes secretion of anti-inflammatory extracellular vesicles from skeletal myotubes via elevation of intracellular calcium level

   Atomu Yamaguchi, Noriaki Maeshige ... Hidemi Fujino

   Ultrasound promotes release of extracellular vesicles from cultured myotubes and elicits anti-inflammatory effects on macrophages, indicating the potential of ultrasound stimulation to muscle for anti-inflammatory purposes.
8. 1. Physics of Living Systems

   A unified approach to dissecting biphasic responses in cell signalling

   Vaidhiswaran Ramesh, J Krishnan
9. 1. Neuroscience

   Modeling apical and basal tree contribution to orientation selectivity in a mouse primary visual cortex layer 2/3 pyramidal cell

   Konstantinos-Evangelos Petousakis, Ji Young Park ... Panayiota Poirazi
10. 1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Dynamic landscape of the intracellular termini of acid-sensing ion channel 1a

    Megan M Cullinan, Robert C Klipp ... John R Bankston

    A novel FRET approach suggests that the intracellular termini of acid-sensing ion channel 1a do not form a complex at rest requiring a new hypothesis for ASIC1a involvement in stroke.