Latest research

1. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   The elemental mechanism of transcriptional pausing

   Jason Saba et al.

   Biochemical analyses of transcription complexes, including kinetic studies and probes of translocational and conformational states, establish the elemental mechanism of pausing, which underlies regulation of gene expression in all organisms.
2. 1. Evolutionary Biology
   2. Microbiology and Infectious Disease

   Symbiont location, host fitness, and possible coadaptation in a symbiosis between social amoebae and bacteria

   Longfei Shu et al.

   Morphological and fitness defects imposed on amoebae hosts by Burkholderia symbionts demonstrates symbiont species-specific effects and provides evidence of host adaptation to naturally acquired symbionts.
3. 1. Cell Biology

   The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1

   Diego Acosta-Alvear et al.

   The coordination of protein targeting to the endoplasmic reticulum and the unfolded protein response through the stress sensor IRE1 ensures quality control of the secreted and transmembrane proteomes.
4. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Crystal structure of a natural light-gated anion channelrhodopsin

   Hai Li et al.

   The atomic structure of GtACR1 provides new insight into the chemical mechanism of natural light-gated anion membrane conductance, and enables its optimization for optogenetic photoinhibition of neuron firing.
5. 1. Neuroscience

   Decreased brain connectivity in smoking contrasts with increased connectivity in drinking

   Wei Cheng et al.

   The findings have a major impact in understanding the different reward systems involved in two types of addictive behavior, and these advances have implications for prevention and treatment.
6. 1. Cancer Biology

   GREB1 amplifies androgen receptor output in human prostate cancer and contributes to antiandrogen resistance

   Eugine Lee et al.

   Prostate cancer cells maintain heterogeneous androgen receptor transcriptional activity through upregulation of AR-regulated coactivator GREB1, and cells with high activity rapidly develop resistance to antiandrogen therapy in a GREB1-dependent manner.
7. 1. Developmental Biology
   2. Structural Biology and Molecular Biophysics

   Engineering a conserved RNA regulatory protein repurposes its biological function in vivo

   Vandita D Bhat et al.
8. 1. Developmental Biology
   2. Neuroscience

   Synapse maintenance is impacted by ATAT-2 tubulin acetyltransferase activity and the RPM-1 signaling hub

   Melissa A Borgen et al.
9. 1. Neuroscience

   CaImAn an open source tool for scalable calcium imaging data analysis

   Andrea Giovannucci et al.

   CaImAn is an open-software package that equips the neuroscience community with a set of turnkey, fast and scalable solutions to pre-processing problems arising in single cell calcium imaging data analysis.
10. 1. Neuroscience

    Nostril-specific and structure-based olfactory learning of chiral discrimination in human adults

    Guo Feng, Wen Zhou

    Training-induced perceptual gain in the discrimination between odor enantiomers is nostril-specific and structure-based, indicating that early olfactory processing of the chemical features of unirhinal input remains plastic in human adults.