Highlights

Latest research

    1. Microbiology and Infectious Disease

    4-aminoquinolines block heme iron reactivity and interfere with artemisinin action

    Melissa R Rosenthal, Daniel E Goldberg
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics

    SETDB1 enables development beyond cleavage stages by extinguishing the MERVL-driven two-cell totipotency transcriptional program in the mouse embryo

    Tie-Bo Zeng, Zhen Fu ... Piroska E Szabó
    Conditional genetics and single-embryo RNA-seq show that SETDB1 extinguishes the transient, retroelement-driven transcriptional programs of the totipotent two-cell state to facilitate the exit from totipotency and ensure preimplantation development.
    1. Neuroscience

    Single molecule counting detects low-copy glycine receptors in hippocampal and striatal synapses

    Serena Camuso, Yana Vella ... Christian G Specht
    Synapses in the forebrain were thought of as purely GABAergic, yet they contain minute numbers of glycine receptors, often in the single digits.
    1. Neuroscience

    Frictional instabilities as an alternative to friction coefficient in fine touch perception

    Maryanne Derkaloustian, Pushpita Bhattacharyya ... Charles B Dhong
    To study fine touch, selecting samples based on how many mechanical instabilities they can form is more predictive than using the friction coefficient, which has been the default choice.
    1. Medicine

    The inactivation of DHHC7 in mouse liver promotes diet-induced obesity through a hepatic Prg4–GPR146 axis

    Yingmin Sun, Ying Liu ... Bing Chen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology

    Human receptive endometrial assembloid for deciphering the implantation window

    Yu Zhang, Rusong Zhao ... Han Zhao
    Revised
    Reviewed Preprint v4
    Updated
    • Important
    • Convincing
    1. Immunology and Inflammation
    2. Cancer Biology

    The 1000+ mouse project: large–scale spatiotemporal parametrization and modeling of preclinical cancer immunotherapies

    Adam L Kenet, Sooraj Achar ... Grégoire Altan-Bonnet
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Ecology
    2. Epidemiology and Global Health

    Rift Valley fever virus dynamics in a transhumant cattle system in The Gambia

    Essa Jarra, Divine Ekwem ... Daniel T Haydon
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid