Latest research

1. 1. Microbiology and Infectious Disease

   A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma

   Dayana C Farhat et al.

   The epitranscriptomic-driven mRNA polyadenylation pathway protects transcriptome integrity by restricting transcriptional read-throughs and RNA chimera formation in apicomplexan parasites and plants.
2. 1. Ecology

   An octopamine receptor confers selective toxicity of amitraz on honeybees and Varroa mites

   Lei Guo et al.

   The structural and pharmacological difference of the invertebrate counterpart of β-adrenergic receptor confers selective toxicity of an insecticide on honeybees and their devastating parasite Varroa mites.
3. 1. Cell Biology
   2. Developmental Biology

   The GNU subunit of PNG kinase, the developmental regulator of mRNA translation, binds BIC-C to localize to RNP granules

   Emir E Avilés-Pagán et al.

   The Drosophila PNG kinase controls mRNA translation at the oocyte-to-embryo transition, and its GNU activating subunit is shown here to bind translational repressors and be a component of RNP granules.
4. 1. Neuroscience

   Spike frequency adaptation supports network computations on temporally dispersed information

   Darjan Salaj et al.

   Spike frequency adaptation provides spiking neural networks with long short-term memory.
5. 1. Structural Biology and Molecular Biophysics

   Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation

   Rouslan G Efremov, Piotr Kolata
6. 1. Ecology
   2. Evolutionary Biology

   Living with relatives offsets the harm caused by pathogens in natural populations

   Hanna M Bensch et al.

   Experiments show that pathogens spread more easily among relatives causing increased mortality, but such costs are cancelled out by the benefits of living with kin when pathogens are rare.
7. 1. Neuroscience

   Predominantly linear summation of metabotropic postsynaptic potentials follows coactivation of neurogliaform interneurons

   Attila Ozsvár et al.
8. 1. Developmental Biology

   Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment

   Shawn A Hallett et al.

   Slow-cycling chondrocytes are maintained in a Wnt-inhibitory environment within the resting zone, unraveling a novel mechanism regulating maintenance and differentiation of parathyroid hormone-related protein (PTHrP)-expressing skeletal stem cells of the postnatal growth plate.
9. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways

   Ryo Miyamoto et al.

   HOXA9 is a transcriptional maintenance factor for anti-apoptotic genes that accelerate MYC-driven leukemia.
10. 1. Neuroscience

    Sequence structure organizes items in varied latent states of working memory neural network

    Qiaoli Huang et al.