Latest research

1. 1. Cell Biology
   2. Developmental Biology and Stem Cells

   Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions

   Amy E Brinegar et al.

   Global transcriptome changes, particularly alternative splicing, are highly dynamic the first 2 weeks after birth, and the example of calcineurin A splicing exemplifies the importance of alternative splicing during skeletal muscle development.
2. 1. Cell Biology

   Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer

   Junke Liu et al.

   In mGlu heterodimers, an oriented asymmetrical activation revealed complex allosteric interaction between subunits.
3. 1. Developmental Biology and Stem Cells

   Dual control of pcdh8l/PCNS expression and function in Xenopus laevis neural crest cells by adam13/33 via the transcription factors tfap2α and arid3a.

   Vikram Khedgikar et al.
4. 1. Plant Biology

   BLADE-ON-PETIOLE proteins act in an E3 ubiquitin ligase complex to regulate PHYTOCHROME INTERACTING FACTOR 4 abundance

   Bo Zhang et al.

   The abundance of the PIF4 transcription factor, central in light and temperature signaling, is controlled by an E3 ligase encoded by BOP proteins.
5. 1. Human Biology and Medicine
   2. Neuroscience

   High-intensity training enhances executive function in children in a randomized, placebo-controlled trial

   David Moreau et al.

   Short bursts of high-intensity exercise elicit robust improvements in core cognitive abilities, especially in individuals whose genotype is associated with lower cognitive performance.
6. 1. Genomics and Evolutionary Biology
   2. Microbiology and Infectious Disease

   Regulation of life span by the gut microbiota in the short-lived African turquoise killifish

   Patrick Smith et al.

   Resetting a young gut microbiota in middle-aged individuals extends life span and slows aging in the naturally short-lived turquoise killifish, a new vertebrate model organism to study how the microbiota affects the aging process.
7. 1. Biochemistry
   2. Biophysics and Structural Biology

   Dynamics and consequences of spliceosome E complex formation

   Joshua Donald Larson, Aaron A Hoskins
8. 1. Neuroscience

   A common directional tuning mechanism of Drosophila motion-sensing neurons in the ON and in the OFF pathway

   Juergen Haag et al.
9. 1. Human Biology and Medicine

   Loss of the melanocortin-4 receptor in mice causes dilated cardiomyopathy

   Michael J Litt et al.

   The melanocortin-4 receptor knockout mouse exhibits a cardiomyopathy syndrome, which raises concerns about cardiovascular function in patients with the similar loss of function mutations, and perhaps even in the 1 in 1500 patients with heterozygous loss of the gene.
10. 1. Neuroscience

    Anatomical and functional organization of the human substantia nigra and its connections

    Yu Zhang et al.