Highlights

  • Closing the neural tube

    High-throughput arrayed CRISPR interference screening of organoid models gives insight into genetic regulators of neural tube closure in humans.

    Roya E Huang, Giridhar M Anand ... Sharad Ramanathan
    Research Article
  • Pikas power yak pastures

    Plateau pikas play a role in enhancing weight gains in yaks, by suppressing toxic plants and improving the availability and quality of palatable forage.

    Zhiwei Zhong, Bingbo Ni ... Zhibin Zhang
    Reviewed Preprint Updated
  • Re-evolving traits

    Hybridization chain reaction and confocal imaging reveal latent ocelli gene regulatory network expression in ant workers, with a role in partial re-evolution of caste-specific traits.

    Angelly Vasquez-Correa, Johanna Arnet ... Ehab Abouheif
    Research Article
  • Publish-review-curate at eLife

    eLife is rethinking how research is reviewed and published.

    Timothy E Behrens, Yamini Dalal, Diane M Harper
    Editorial
  • AI in research communication

    eLife has partnered on a number of projects harnessing AI for improving human and machine reader engagement with research.

    Inside eLife
  • Science under threat

    How should the scientific community respond to ideological attacks on science?

    Humberto J Debat
    Feature Article

Latest research

    1. Genetics and Genomics

    Systematic cross-study assessment of RNA-Seq experimental workflows for plasma cell-free transcriptome profiling

    Cristina Tuñí-Domínguez, Giovanni Asole ... Julien Lagarde
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Multi-timescale dynamics organize descending pain modulation

    Carl Ashworth, Melissa Martenson ... Flavia Mancini
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Ecology

    Monkey hear, monkey do what? An application of Automated Behavioural Response systems for hypothesis testing in the world’s smallest monkey

    Larissa Barker, Sarah Papworth
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Prenatal Alcohol Exposure Disrupts γ-Secretase Activity and Impairs Learning and Memory in Wild-Type and 3xTg-AD Mice

    Paola Montenegro, Rachel Kim ... Hermes Yeh
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Evolution imposes an inductive bias that alters and accelerates learning dynamics

    Benjamin Midler, Alejandro Pan Vazquez
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Plant Biology

    Story about honest mistakes: The cyanobacterium Synechocystis has a promiscuous Entner-Doudoroff (ED) aldolase but no functional ED pathway

    Ravi Shankar Ojha, Marius Theune ... Kirstin Gutekunst
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Microbiology and Infectious Disease

    The cow udder is a potential coinfection site for influenza A viruses

    Rute Maria Pinto, Colin P Sharp ... Paul Digard
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Neuroscience

    A Functional Influence Based Circuit Motif That Constrains the Set of Plausible Algorithms of Cortical Function

    Anna Vasilevskaya, Georg B Keller
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Cancer Biology

    Impacts of mutation accumulation and order on tumor initiation revealed by engineered murine colorectal cancer organoids

    Yanping Li, Xiaoxin Xie ... Qionghua Zhu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid