Latest research

1. 1. Computational and Systems Biology

   Mouse aging cell atlas analysis reveals global and cell type-specific aging signatures

   Martin Jinye Zhang et al.

   Comprehensive single-cell transcriptome analysis reveals global and tissue-specific aging markers and characterizes the heterogeneous aging status of different cell types and tissues in mouse.
2. 1. Cell Biology
   2. Neuroscience

   Neuronal junctophilins recruit specific Ca_V and RyR isoforms to ER-PM junctions and functionally alter Ca_V2.1 and Ca_V2.2

   Stefano Perni, Kurt Beam

   Neuronal junctophilins 3 and 4 similarly recruit and functionally modify P/Q and N-type calcium channels, but differentially recruit the three ryanodine receptor isoforms to endoplasmic reticulum-plasma membrane junctions.
3. 1. Medicine
   2. Neuroscience

   PMCA generated prions from the olfactory mucosa of patients with Fatal Familial Insomnia cause prion disease in mice

   Edoardo Bistaffa et al.
4. 1. Neuroscience

   Circuit organization of the excitatory sensorimotor loop through hand/forelimb S1 and M1

   Naoki Yamawaki et al.

   Cell-type-specific circuit analysis reveals a highly polysynaptic pattern of excitatory feedforward connections along the somatosensory-to-motor loop, from cuneate via VPL thalamus to S1 and M1 cortex and corticospinal neurons.
5. 1. Microbiology and Infectious Disease

   Cerebrospinal fluid proteome maps detect pathogen-specific host response patterns in meningitis

   Anahita Bakochi et al.

   Statistical analysis and LASSO regression modeling provide insights into pathogen-specific host response patterns in cerebrospinal fluid from different disease etiologies to support future classification of pathogen type based on host response patterns in meningitis.
6. 1. Neuroscience

   IGF-1 facilitates extinction of conditioned fear

   Laura E Maglio et al.

   Insulin-like growth factor-1 activates the prefrontal cortex and improves the extinction of aversive memories.
7. 1. Structural Biology and Molecular Biophysics

   Cryo-EM structure of the yeast TREX complex and coordination with the SR-like protein Gbp2

   Yihu Xie et al.

   Cryo-EM and chemical cross-linking studies yield an atomic resolution structure of a conserved remodeling machinery in messenger ribonucleoprotein maturation/nuclear export and insights into its coordinated function with a serine–arginine protein.
8. 1. Computational and Systems Biology
   2. Neuroscience

   Action detection using a neural network elucidates the genetics of mouse grooming behavior

   Brian Q Geuther et al.

   A machine learning method for action detection is developed and applied toward mouse grooming behavior.
9. 1. Biochemistry and Chemical Biology

   Mapping the functional landscape of the receptor binding domain of T7 bacteriophage by deep mutational scanning

   Phil Huss et al.

   An unbiased mutational screen decodes the molecular basis of phage receptor interactions, identifies key functional regions determining activity and host range, and demonstrates the potential for engineering therapeutic phages.
10. 1. Chromosomes and Gene Expression
    2. Medicine

    Cardiovascular disease risk factors induce mesenchymal features and senescence in mouse cardiac endothelial cells

    Karthik Amudhala Hemanthakumar et al.

    Endothelial dysfunction due to cardiovascular disease risk factors explained by cardiac endothelial cell transcriptome remodelling.