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Latest research

    1. Cancer Biology
    2. Cell Biology

    Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation

    Maxim I Maron et al.
    Biochemical, transcriptomic, and proteomic analyses reveal that protein arginine methyltransferases post-transcriptionally regulate intron detention—introns that persist in nuclear polyadenylated RNA—through methylation of RNA splicing and processing factors.
    1. Epidemiology and Global Health

    Social contact patterns and implications for infectious disease transmission – a systematic review and meta-analysis of contact surveys

    Andria Mousa et al.
    Differences in patterns of social contact between settings have consequences for the spread and transmission of respiratory pathogens and the effectiveness of different measures aimed at their control.
    1. Neuroscience

    Similar neural and perceptual masking effects of low-power optogenetic stimulation in primate V1

    Spencer Chin-Yu Chen et al.
    Simultaneous optogenetic stimulation and calcium imaging in V1 of behaving macaques reveals that low-power optostimulation can substitute a visual mask and significantly reduce perceptual and neural detection sensitivities.
    1. Developmental Biology
    2. Evolutionary Biology

    Cavefish cope with environmental hypoxia by developing more erythrocytes and overexpression of hypoxia-inducible genes

    Corine M van der Weele, William R Jeffery
    Astyanax mexicanus cavefish cope with hypoxic environments by expanding embryonic hematopoietic domains, increasing the capacity for erythrocyte development, and constitutive overexpression of hypoxia-inducible genes.
    1. Cell Biology
    2. Developmental Biology

    Autophagosomes fuse to phagosomes and facilitate the degradation of apoptotic cells in Caenorhabditis elegans

    Omar Peña-Ramos et al.
    The crosstalk between autophagy and the phagocytosis of apoptotic cells, two cellular clearance pathways, promotes the fusion of the double-membrane autophagosomes to the phagosomes and plays an important role in the degradation of engulfed apoptotic cells.
    1. Neuroscience

    Context-dependent relationships between locus coeruleus firing patterns and coordinated neural activity in the anterior cingulate cortex

    Siddhartha Joshi, Joshua I Gold
    Simultaneous recordings in brainstem and cortex, combined with pupillometry, show that changes in coordinated activity in anterior cingulate cortex are related to distinct patterns of pupil-linked activation of the locus coeruleus-norepinephrine system.
    1. Neuroscience
    2. Physics of Living Systems

    A theory of synaptic transmission

    Bin Wang, Olga K Dudko
    The analytic theory establishes the general principles of synaptic transmission, enables extraction of microscopic parameters of synaptic fusion machinery from experiments, and links molecular constituents to synaptic function.
    1. Evolutionary Biology

    The population genetics of collateral resistance and sensitivity

    Sarah M Ardell, Sergey Kryazhimskiy
    A theoretical model that considers the diversity of collateral effects among drug resistance mutations provides insights into the development of robust sequential antibiotic treatments.
    1. Developmental Biology
    2. Neuroscience

    PRC1 sustains the integrity of neural fate in the absence of PRC2 function

    Ayana Sawai et al.
    Regulation of neuronal diversity and fate through protein complexes involved in gene repression and chromatin condensation.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Genetic basis and dual adaptive role of floral pigmentation in sunflowers

    Marco Todesco et al.
    Variation in patterns of floral UV pigmentation is controlled by a single transcription factor in sunflower and affects both pollinator attraction and responses to environmental stresses.