Latest research

1. 1. Neuroscience

   GABA_B receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals

   Pradeep Bhandari et al.

   The direct interaction of R-type Ca²⁺ channel Cav2.3 and GABA_B receptor auxiliary subunits in the active zone of medial habenula terminals scales synaptic strength independent of GABA_B receptor activation.
2. 1. Epidemiology and Global Health
   2. Medicine

   Effects of an urban sanitation intervention on childhood enteric infection and diarrhea in Maputo, Mozambique: A controlled before-and-after trial

   Jackie Knee et al.

   Onsite sanitation maybe insufficient to interrupt transmission of enteric infections in high-burden urban settings, though risk of some infections may be reduced among children protected from birth.
3. 1. Neuroscience

   Response-based outcome predictions and confidence regulate feedback processing and learning

   Romy Frömer et al.

   Computational modeling, and empirical behavioral and EEG results show that learning relies not only on comparing current events to past experience, but integrates response-based outcome predictions and confidence.
4. 1. Structural Biology and Molecular Biophysics

   Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction

   Subu Subramanian et al.

   Deep mutagenesis of a clamp-loader complex reveals a critical hydrogen-bonded junction that is important for allosteric communication in oligomeric AAA+ ATPases.
5. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   IL-33 promotes innate lymphoid cell-dependent IFN-γ production required for innate immunity to Toxoplasma gondii

   Joseph T Clark et al.

   Upon Toxoplasma gondii infection, IL-33 plays a critical role in driving early anti-parasite responses by innate lymphoid cells rendered responsive to its effects by infection.
6. 1. Cell Biology

   Receptor-mediated mitophagy regulates EPO production and protects against renal anemia

   Guangfeng Geng et al.

   Fundc1-mediated mitophagy protects renal EPO-producing cells from myofibroblastic conversion under stresses.
7. 1. Neuroscience

   Distinct protocerebral neuropils associated with attractive and aversive female-produced odorants in the male moth brain

   Jonas Hansen Kymre et al.
8. 1. Cell Biology
   2. Chromosomes and Gene Expression

   A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing

   Yu-Xuan Lu et al.
9. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   A subcellular map of the human kinome

   Haitao Zhang et al.
10. 1. Epidemiology and Global Health
    2. Medicine

    Do wealth and inequality associate with health in a small-scale subsistence society?

    Adrian V Jaeggi et al.