Latest research

1. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM

   Valeria Kalienkova et al.
2. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Programmed conversion of hypertrophic chondrocytes into osteoblasts and marrow adipocytes within zebrafish bones

   Dion Giovannone et al.
3. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Schnyder corneal dystrophy-associated UBIAD1 Inhibits ER-associated degradation of HMG CoA reductase in mice

   Youngah Jo et al.
4. 1. Structural Biology and Molecular Biophysics

   Structural insights into SETD3-mediated histidine methylation on β-actin

   Qiong Guo et al.
5. 1. Structural Biology and Molecular Biophysics

   Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F

   Carolina Alvadia et al.
6. 1. Genetics and Genomics
   2. Stem Cells and Regenerative Medicine

   The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders

   Cheen Euong Ang et al.

   lnc-Nr2f1, a long non-coding RNA focally deleted in autism patients, directly occupies and regulates neuronal genes.
7. 1. Developmental Biology

   Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification

   Rodrigo M Young et al.

   Disruptions to eye field size have little impact on final eye size due to tissue compensatory mechanisms.
8. 1. Plant Biology

   Multiple pairs of allelic MLA immune receptor-powdery mildew AVR_A effectors argue for a direct recognition mechanism

   Isabel ML Saur et al.
9. 1. Neuroscience

   Cold-inducible RNA-binding protein (CIRBP) adjusts clock-gene expression and REM-sleep recovery following sleep deprivation

   Marieke MB Hoekstra et al.

   The temperature-sensitive protein CIRBP contributes to the effect of sleep loss on the molecular circadian clock.
10. 1. Chromosomes and Gene Expression
    2. Developmental Biology

    Mi-2/NuRD complex protects stem cell progeny from mitogenic Notch signaling

    Evanthia Zacharioudaki et al.

    Depleting Mi-2 in the progeny of neural stem cells prevents normal enhancer decommissioning so that they become sensitive to Notch activity and re-acquire stem cell properties.