Latest research

1. 1. Microbiology and Infectious Disease

   Distinct regions of H. pylori’s bactofilin CcmA regulate protein–protein interactions to control helical cell shape

   Sophie R Sichel, Benjamin P Bratton, Nina R Salama

   The helical cell shape of Helicobacter pylori depends on the polymerizing cytoskeletal protein CcmA’s recruitment to the cell envelope by Csd5 and CcmA’s indirect stabilization of a periplasmic cell wall hydrolase via interactions with the transmembrane protein Csd7.
2. 1. Developmental Biology
   2. Neuroscience

   Photoreceptors generate neuronal diversity in their target field through a Hedgehog morphogen gradient in Drosophila

   Matthew P Bostock, Anadika R Prasad ... Vilaiwan M Fernandes

   Photoreceptors diversify their target field at long range through a graded signal.
3. 1. Developmental Biology
   2. Neuroscience

   Differentiation signals from glia are fine-tuned to set neuronal numbers during development

   Anadika R Prasad, Inês Lago-Baldaia ... Vilaiwan M Fernandes

   Extrinsic signals establish an invariant and stereotyped pattern of neuronal differentiation and programmed cell death in the Drosophila visual system.
4. 1. Cell Biology

   PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells

   Gina M LoMastro, Chelsea G Drown ... Andrew Jon Holland

   Genetically engineered mouse models show that PLK4 protein and kinase activity are essential for multiciliogenesis, demonstrating that the early steps of centriole assembly are conserved between cycling and multiciliated cells.
5. 1. Cell Biology
   2. Genetics and Genomics

   The VINE complex is an endosomal VPS9-domain GEF and SNX-BAR coat

   Shawn P Shortill, Mia S Frier ... Elizabeth Conibear

   The yeast VARP homolog forms a new sorting nexin complex that promotes its own membrane recruitment through GEF activity and regulates the distribution of endosomal proteins.
6. 1. Cell Biology

   Consequences of PDGFR a ⁺ fibroblast reduction in adult murine hearts

   Jill T Kuwabara, Akitoshi Hara ... Michelle D Tallquist
7. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Rapid, reference-free human genotype imputation with denoising autoencoders

   Raquel Dias, Doug Evans ... Ali Torkamani
8. 1. Neuroscience

   Non-rapid eye movement sleep determines resilience to social stress normal

   Brittany J Bush, Caroline Donnay ... J Christopher Ehlen
9. 1. Developmental Biology

   Regulation of Nodal signaling propagation by receptor interactions and positive feedback

   Hannes Preiß, Anna C Kögler ... Patrick Müller
10. 1. Biochemistry and Chemical Biology
    2. Cell Biology

    A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation

    Edmundo G Vides, Ayan Adhikari ... Suzanne R Pfeffer