Highlights

  • Replication in Drosophila studies

    An analysis of 400 articles on the immune response in Drosophila highlights a need for caution regarding the replicability of certain claims.

    Hannah Westlake, Fabrice David ... Bruno Lemaitre
    Reviewed Preprint Updated

  • Tsetse fly feeding adaptations

    Investigations into the biomechanics of tsetse fly blood feeding reveal that subtle anatomical adaptations enable the penetration of a diverse range of host hides.

    Stephan Löwe, Laura Hauf ... Markus Engstler
    Research Article

  • Anatomy of taste and texture

    Comprehensive ultrastructural reconstruction of the Drosophila larval pharyngeal sensory system reveals the organization and diversity of its sensory structures.

    Vincent Richter, Tilman Triphan ... Andreas S Thum
    Research Article

  • Neurosecretory connections

    Connectomic and transcriptomic analyses reveal the anatomical and functional organisation of neurosecretion in the Drosophila brain.

    Theresa H McKim, Jayati Gera ... Meet Zandawala
    Research Article

  • AI in research communication

    eLife has partnered on a number of projects harnessing AI for improving human and machine reader engagement with research.

    Inside eLife

  • Explore our new collection

    Delve into leading research on Lifestyle, Environment and Epigenetic Inheritance.

    Collection
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Neuroscience

    Functional maturation in abducens motoneurons populations during angular VOR larval development

    Mathilde Pain, Marie Boulain ... François M Lambert
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cancer Biology

    Targeting Polθ Helicase with RP-3467: Preclinical Validation and Clinical Response in a gBRCA1 ovarian cancer patient with an acquired PARPi resistance mutation in TP53BP1

    Ezra Y Rosen, Marie-Claude Mathieu ... Agnel Sfeir
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Female acoustic signaling of sexual immaturity depresses male courtship in Drosophila

    Martin Bernet, Anne C von Philipsborn
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Dual reinforcement-learning network modules for modeling decision-making with multiple strategies

    Hayato Maeda, Shuo Wang, Akihiro Funamizu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Developmental Biology
    2. Neuroscience

    A comparative single-cell transcriptomic atlas for diverse populations of vertebrate hair cells

    Mahashweta Basu, Nesrine Benkafadar ... Lisa V Goodrich
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    A complementary learning system for continual episodic memory in large language models

    Xu Pan, Ely Hahami ... Haim Sompolinsky
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Stem Cells and Regenerative Medicine

    Stimulating neurogenesis of distinct retinal lineages in human retinal pigmented epithelium (RPE) with proneural transcription factors

    Lew Kaplan, Abigail L Green ... Thomas A Reh
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in colorectal cancer

    Qian Wang, Liping Li ... Chuo Chen
    Catalytic inhibition of tankyrase induces tankyrase accumulation and rigidifies the β-catenin destruction complex, limiting its ability to suppress WNT signaling.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

    Sarah M Chang, Muhammad Bin Munim ... Matthew G Vander Heiden
    Examining the metabolic response of cancer cells to nutrient depletion reveals how the cell NAD+/NADH ratio can determine what nutrient environments are compatible with cancer cell proliferation.
    1. Genetics and Genomics
    2. Medicine

    Estimating bone marrow adiposity from head MRI and identifying its genetic architecture

    Tobias Kaufmann, Pål Marius Bjørnstad ... Timothy Hughes
    Previously overlooked information in standard head MRI scans combined with a novel deep learning method enables large-scale investigation of human bone marrow biology across existing imaging cohorts.
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Magazine

    1. Cell Biology
    2. Physiology

    Mechanosensory Physiology: Lymphatic vessels under pressure

    Asser F Bedair, Osama F Harraz
    1. Epidemiology and Global Health

    Science Forum: The new paradox of women’s health research

    Ursula Debarnot, Alexandre Fouré
    1. Genetics and Genomics
    2. Physiology

    Steroid Signaling: A hormonal message for a longer life

    Kyle Feola, Peter M Douglas
    1. Microbiology and Infectious Disease

    Bird Flu: The cow udder as an influenza mixing ground

    Silke Rimaux, Robert P de Vries
    1. Computational and Systems Biology

    AI in Science: The 42 problem in AI-assisted research

    Giovanni Spitale, Federico Germani
    1. Genetics and Genomics
    2. Developmental Biology
    grid of multicoloured bar graphs with vertical shaded areas in red and green highlighting specific columns

    Lifestyle, Environment and Epigenetic Inheritance: A Collection of Articles

    Edited by Wei Yan

  7. Research Culture: From East to West – an early-career researcher’s voyage across continents

    Samuel C Eziuzor
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
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  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
  16. Physiology
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  19. Structural Biology and Molecular Biophysics
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