Latest research

1. 1. Neuroscience

   Eye movements reveal spatiotemporal dynamics of visually-informed planning in navigation

   Seren Zhu et al.

   The spatial and temporal patterns of eye movements exhibited by humans in virtual reality reveal how they plan paths when navigating in complex, naturalistic environments.
2. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   Unifying the known and unknown microbial coding sequence space

   Chiara Vanni et al.

   A newly developed computational framework provides an overview of the extent, diversity, and relevance of the genes of unknown function in genomes and metagenomes.
3. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation

   Morgane Boone et al.

   Genetically induced conformational modulation of eIF2B activates the Integrated Stress Response by impairing nucleotide exchange.
4. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Structural, mechanistic, and physiological insights into phospholipase A-mediated membrane phospholipid degradation in Pseudomonas aeruginosa

   Florian Bleffert et al.

   Membrane homeostasis in bacteria relies on the controlled degradation of endogenous phospholipids by intracellular phospholipases A, however their structures and catalytic mechanism are still poorly understood.
5. 1. Medicine
   2. Neuroscience

   Multi-tract multi-symptom relationships in pediatric concussion

   Guido I Guberman et al.

   In paediatric concussions, there are a multiplicity of ways that brain damage gives rise to symptoms, most of which are missed by conventional statistical approaches and study designs.
6. 1. Epidemiology and Global Health
   2. Medicine

   Type 2 diabetes mellitus accelerates brain aging and cognitive decline: Complementary findings from UK Biobank and meta-analyses

   Botond Antal et al.

   Patients with Type 2 diabetes show patterns of neurodegeneration consistent with accelerated brain aging, including impaired cognition and loss of brain volume, which are more severe in those with increased disease duration.
7. 1. Cell Biology

   MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass

   Ellen Busschers et al.
8. 1. Neuroscience

   Drosophila gustatory projections are segregated by taste modality and connectivity

   Stefanie Engert et al.
9. 1. Neuroscience

   Perception of an object’s global shape is best described by a model of skeletal structure in human infants

   Vladislav Ayzenberg, Stella Lourenco

   Six- to twelve-month old infants, who have little linguistic or object experience, classify objects by relying on a invariant representation of global shape known as the shape skeleton.
10. 1. Computational and Systems Biology
    2. Medicine

    Development and evaluation of a machine learning-based in-hospital COVID-19 disease outcome predictor (CODOP): A multicontinental retrospective study

    Riku Klén et al.

    The generalizability of CODOP in distinct world regions and its flexibility to reckon with the changing availability of hospital resources makes it a clinically useful tool potentially improving the outcome prediction and the management of COVID-19 hospitalized patients.