Latest research

1. 1. Biochemistry and Chemical Biology

   Non-enzymatic primer extension with strand displacement

   Lijun Zhou et al.

   Relying on RNA fragments derived from degradation or partial template copying, non-enzymatic primer extension with strand displacement offers a novel and prebiotically plausible approach to RNA self-replication.
2. 1. Cell Biology
   2. Genetics and Genomics

   The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

   Heather P Harding et al.
3. 1. Neuroscience

   A projection specific logic to sampling visual inputs in mouse superior colliculus

   Katja Reinhard et al.

   Transsynaptic viral tracing reveals that neurons in the superior colliculus employ projection specific rules to the sampling of retinal inputs, directing distinct visual features to different downstream targets.
4. 1. Cell Biology
   2. Structural Biology and Molecular Biophysics

   A microtranslatome coordinately regulates sodium and potassium currents in the human heart

   Catherine A Eichel et al.

   Association of mRNA in discrete, cotranslational complexes regulates currents controlling excitability in human cardiomyocytes.
5. 1. Evolutionary Biology

   Selection on mutators is not frequency-dependent

   Yevgeniy Raynes, Daniel Weinreich

   Contrary to intuition that the evolutionary fate of mutation rate modifying alleles is frequency-dependent, neither the strength nor the sign of selection on modifiers depends on initial frequency.
6. 1. Microbiology and Infectious Disease

   Perinatal hormones favor CC17 group B Streptococcus intestinal translocation through M cells and hypervirulence in neonates

   Constantin Hays et al.

   Hormonal concentrations found in over 7-day-old neonates favor CC17 GBS invasiveness in a process linked to intestinal M cells maturation and mediated by the CC17 GBS surface protein Srr2.
7. 1. Immunology and Inflammation

   Drosophila macrophages switch to aerobic glycolysis to mount effective antibacterial defense

   Gabriela Krejčová et al.

   Activated Drosophila macrophages undergo transient metabolic remodeling towards Hypoxia inducible factor 1 α-driven aerobic glycolysis, a program that induces systemic metabolic changes and is crucial for resistance to infection.
8. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Profilin and formin constitute a pacemaker system for robust actin filament growth

   Johanna Funk et al.

   Profilin release from the filament end controls the speed of actin growth at physiological conditions.
9. 1. Chromosomes and Gene Expression
   2. Evolutionary Biology

   Chromatinization of Escherichia coli with archaeal histones

   Maria Rojec et al.

   Escherichia coli is surprisingly tolerant to chromatinization by archaeal histones, suggesting that histones can become established as ubiquitous chromatin proteins without interfering critically with some key DNA-templated processes.
10. 1. Developmental Biology
    2. Genetics and Genomics

    Combinatorial chromatin dynamics foster accurate cardiopharyngeal fate choices

    Claudia Racioppi et al.