Latest research

1. 1. Cell Biology
   2. Evolutionary Biology

   A unicellular relative of animals generates a layer of polarized cells by actomyosin-dependent cellularization

   Omaya Dudin et al.

   Cellularization in Sphaeroforma arctica generates a self-organized structure that morphologically resembles an epithelium, and is associated with tightly regulated expression of cell adhesion pathways.
2. 1. Developmental Biology
   2. Evolutionary Biology

   Evolutionary loss of foot muscle during development with characteristics of atrophy and no evidence of cell death

   Mai P Tran et al.

   Evolutionary loss of foot muscle in a bipedal rodent shares similarities with skeletal muscle atrophy, which is typically considered a pathological response to injury or disease.
3. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Chromosome territory formation attenuates the translocation potential of cells

   Leah F Rosin et al.

   The translocation potential of cells can be modulated by Condensin II activity during interphase.
4. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid

   Leslie A McCauliff et al.

   Sterol kinetics and cell-based assays reveal a heretofore unknown step in cholesterol trafficking through the endolysosomal compartment, involving a direct functional interaction between NPC2 and lysosbisphosphatidic acid.
5. 1. Cell Biology
   2. Developmental Biology

   Single-cell proteomics reveals changes in expression during hair-cell development

   Ying Zhu et al.

   Protein mass spectrometry can be used to uncover developmental trajectories in small single cells of differentiating tissues.
6. 1. Structural Biology and Molecular Biophysics

   Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding

   Janelle Lauer et al.

   Understanding the complex auto-regulatory mechanisms for guanine nucleotide exchange factors is critically important for fully appreciating the layers of control for small GTPases.
7. 1. Structural Biology and Molecular Biophysics

   The ion selectivity filter is not an activation gate in TRPV1-3 channels

   Andrés Jara-Oseguera et al.
8. 1. Neuroscience

   Stimulating the hippocampal posterior-medial network enhances task-dependent connectivity and memory

   Kristen N Warren et al.

   Noninvasive stimulation of hippocampal networks increases connectivity in a functionally-specific manner that is highly relevant to effective episodic memory performance that depends on the targeted network.
9. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Formation of a β-barrel membrane protein is catalyzed by the interior surface of the assembly machine protein BamA

   James Lee et al.
10. 1. Neuroscience

    Nitric oxide acts as a cotransmitter in a subset of dopaminergic neurons to diversify memory dynamics

    Yoshinori Aso et al.