Highlights

  • The hunger response in flies

    An enzyme called Pect regulates insulin sensitivity and hunger response in flies.

    Kevin P Kelly, Mroj Alassaf ... Akhila Rajan
    Research Article Updated
  • Megacytes versus malaria

    Giant cells called megacytes help protect mosquitoes against the Plasmodium parasites that cause malaria.

    Ana Beatriz F Barletta, Banhisikha Saha ... Carolina Barillas-Mury
    Research Article Updated
  • Regulating neural crest cells

    An RNA-binding protein called Elavl1/HuR is required to maintain specification of cranial neural crest cells.

    Erica J Hutchins, Shashank Gandhi ... Marianne E Bronner
    Short Report

Latest research

    1. Structural Biology and Molecular Biophysics

    Determination of oligomeric states of proteins via dual-color colocalization with single molecule localization microscopy

    Hua Leonhard Tan, Stefanie Bungert-Plümke ... Gabriel Stölting
    The DCC-SMLM algorithm allows to determine protein oligomeric states in situ, using the information obtained from the colocalization of fluorescent markers, overcoming the need for extraction of proteins from cells or complicated experimental setups when using microscopy.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Highly efficient generation of isogenic pluripotent stem cell models using prime editing

    Hanqin Li, Oriol Busquets ... Frank Soldner
    A highly efficient platform to engineer designer mutations in human stem cells using RNA-based delivery of prime editing components.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation

    Wesley L Cai, Jocelyn Fang-Yi Chen ... Qin Yan
    The chromatin regulator WDR5 is a regulator of translation, and small molecule inhibitors or degraders of WDR5 can be used to treat triple-negative breast cancer.
    1. Immunology and Inflammation

    Single-cell RNA sequencing analysis of shrimp immune cells identifies macrophage-like phagocytes

    Peng Yang, Yaohui Chen ... Fan Wang
    A novel innate immune cell subset in shrimp shows similarities with human macrophage.
    1. Cell Biology

    Development of a versatile high-throughput mutagenesis assay with multiplexed short-read NGS using DNA-barcoded supF shuttle vector library amplified in E. coli

    Hidehiko Kawai, Ren Iwata ... Hiroyuki Kamiya
    A sophisticated classical mutagenesis assay with next-generation sequencing technology presents a benefit to future research on mutagenesis, DNA repair, and cancer.
    1. Cell Biology
    2. Neuroscience

    Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming

    Christian Keine, Mohammed Al-Yaari ... Samuel M Young Jr
    A combination of genetic, electrophysiological, and modeling approaches reveals that presynaptic Rac1 is a key molecule that controls synaptic strength and plasticity by regulating the synaptic vesicle cycle steps controlling the number of fusion competent synaptic vesicles.
    1. Developmental Biology
    2. Plant Biology

    The circadian clock controls temporal and spatial patterns of floral development in sunflower

    Carine M. Marshall, Veronica L. Thompson ... Stacey L. Harmer
    1. Epidemiology and Global Health

    The role of adolescent lifestyle habits in biological aging: A prospective twin study

    Anna Kankaanpää, Asko Tolvanen ... Elina Sillanpää