Latest research

1. 1. Genetics and Genomics
   2. Stem Cells and Regenerative Medicine

   The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders

   Cheen Euong Ang et al.

   lnc-Nr2f1, a long non-coding RNA focally deleted in autism patients, directly occupies and regulates neuronal genes.
2. 1. Plant Biology

   Multiple pairs of allelic MLA immune receptor-powdery mildew AVR_A effectors argue for a direct recognition mechanism

   Isabel ML Saur et al.
3. 1. Developmental Biology

   Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification

   Rodrigo M Young et al.

   Disruptions to eye field size have little impact on final eye size due to tissue compensatory mechanisms.
4. 1. Neuroscience

   Cold-inducible RNA-binding protein (CIRBP) adjusts clock-gene expression and REM-sleep recovery following sleep deprivation

   Marieke MB Hoekstra et al.

   The temperature-sensitive protein CIRBP contributes to the effect of sleep loss on the molecular circadian clock.
5. 1. Chromosomes and Gene Expression
   2. Developmental Biology

   Mi-2/NuRD complex protects stem cell progeny from mitogenic Notch signaling

   Evanthia Zacharioudaki et al.

   Depleting Mi-2 in the progeny of neural stem cells prevents normal enhancer decommissioning so that they become sensitive to Notch activity and re-acquire stem cell properties.
6. 1. Evolutionary Biology
   2. Neuroscience

   Quantitative uniqueness of human brain evolution revealed through phylogenetic comparative analysis

   Ian F Miller et al.

   The exceptionally large size of the human brain is the result of accelerating evolution towards larger brains in hominins, but is not the product of neocortical expansion.
7. 1. Cell Biology
   2. Human Biology and Medicine

   Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases

   King Faisal Yambire et al.

   Transcription factors KLF2 and ETV1 repress the transcriptional program of mitochondrial biogenesis, resulting in impaired mitochondrial function in lysosomal storage diseases.
8. 1. Neuroscience
   2. Structural Biology and Molecular Biophysics

   Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs

   David M Kern et al.
9. 1. Microbiology and Infectious Disease
   2. Physics of Living Systems

   Mechanics and dynamics of translocating MreB filaments on curved membranes

   Felix Wong et al.
10. 1. Developmental Biology

    Generation of the squamous epithelial roof of the 4^th ventricle

    Florent Campo-Paysaa et al.