Highlights

We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Neuroscience

    Psilocybin asymmetrically modulates outcome-based choice and cortical processing under uncertainty

    David Jacobs, Alejandro Torrado Pacheco ... Bita Moghaddam
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    WNK-SPAK/OSR1 signaling pathway facilitates ictal activity via reduced neuronal chloride extrusion rate

    Volodymyr I Dzhala, Fu Hung Shiu ... Kevin J Staley
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Preferential formation of NUP98::KDM5A condensates at specific H3K4me3-rich loci drives leukemogenic gene expression

    Augusto Berrocal, Jonathan E Sandoval ... Bo Huang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    A neural mechanism for compositional structure transfer in humans

    Lennart Luettgau, Nan Chen ... Raymond J Dolan
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Oxytocin neurons signal state-dependent transitions from rest to thermogenesis and behavioral arousal

    Morgane Vandendoren, Jason G Landen ... Adam Nelson
    Oxytocin neurons couple physiological warming to behavioral arousal, revealing a homeostatic mechanism that coordinates transitions between low- and high-energy states.
    1. Neuroscience

    Compensation of hyperexcitability with simulation-based inference

    Daniel Müller-Komorowska, Tomoki Fukai
    Simulation-based inference predicts putative circuit mechanisms of hyperexcitability in a phenomenological microcircuit simulator with more than 30 free intrinsic and synaptic parameters.
    1. Cell Biology

    SVEP1 enables efficient binding of angiopoietin-2 to the TIE1 receptor, allowing receptor phosphorylation and downstream signaling

    Katharina Uphoff, Melina Hußmann ... Dörte Schulte-Ostermann
    The interaction of important signaling pathway members identified through in silico and in vitro approaches provides a model that suggests local receptor multimerization through bridging functions of various ligands.
    1. Neuroscience

    Distinct gradients of cortical architecture capture visual representations and behavior across the lifespan

    Xiayu Chen, Xingyu Liu ... Jesse Gomez
    A large-scale convergence gradient and a fine-scale divergence gradient in cortical architecture capture visual hierarchy, areal boundaries, and behavior, uncovering an undescribed retinotopic representation in anterior temporal cortex.
    1. Neuroscience
    2. Physiology

    Fitness level, but not sex, affects exercise-induced pain modulation

    Janne Ina Nold, Tahmine Fadai ... Christian Büchel
    Physical fitness may explain individual variability in exercise-related pain modulation, particularly for heat pain while sex may not substantially influence these responses across conditions.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Calibrated analysis framework for nanopore direct RNA sequencing uncovers cell-specific m⁶A proportions at conserved sites

    Denise Ohnezeit, Elene Loliashvili ... Angus C Wilson
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
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Magazine

    1. Cell Biology
    2. Physiology

    Mechanosensory Physiology: Lymphatic vessels under pressure

    Asser F Bedair, Osama F Harraz
    1. Epidemiology and Global Health

    Science Forum: The new paradox of women’s health research

    Ursula Debarnot, Alexandre Fouré
    1. Genetics and Genomics
    2. Physiology

    Steroid Signaling: A hormonal message for a longer life

    Kyle Feola, Peter M Douglas
    1. Microbiology and Infectious Disease

    Bird Flu: The cow udder as an influenza mixing ground

    Silke Rimaux, Robert P de Vries
    1. Computational and Systems Biology

    AI in Science: The 42 problem in AI-assisted research

    Giovanni Spitale, Federico Germani
    1. Genetics and Genomics
    2. Developmental Biology
    grid of multicoloured bar graphs with vertical shaded areas in red and green highlighting specific columns

    Lifestyle, Environment and Epigenetic Inheritance: A Collection of Articles

    Edited by Wei Yan

  7. Research Culture: From East to West – an early-career researcher’s voyage across continents

    Samuel C Eziuzor
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
  16. Physiology
  17. Plant Biology
  18. Stem Cells and Regenerative Medicine
  19. Structural Biology and Molecular Biophysics
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