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Rewiring MAP kinases in Saccharomyces cerevisiae to regulate novel targets through ubiquitination

Two sets of modular components are sufficient to rewire MAPKs to regulate proteins through ubiquitination – a complementary pair of protein interaction domains and a phosphodegron.
  • Benjamin Groves
  • Arjun Khakhar
  • Cory M Nadel
  • Richard G Gardner
  • Georg Seelig
10.7554/eLife.15200
Research Article Cell Biology Computational and Systems Biology
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Hippocampal neurogenesis enhancers promote forgetting of remote fear memory after hippocampal reactivation by retrieval

Forgetting of remote fear memory is promoted by increased hippocampal neurogenesis only after hippocampal reactivation by long time memory retrieval.
  • Rie Ishikawa
  • Hotaka Fukushima
  • Paul W Frankland
  • Satoshi Kida
10.7554/eLife.17464
Research Article Neuroscience
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Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons

In rodents and primates, there are two subtypes of parvalbumin-expressing interneurons that provide novel substrates for selective inhibition in the striatum.
  • Farid N Garas
  • Rahul S Shah
  • Eszter Kormann
  • Natalie M Doig
  • Federica Vinciati
  • Kouichi C Nakamura
  • Matthijs C Dorst
  • Yoland Smith
  • Peter J Magill
  • Andrew Sharott
10.7554/eLife.16088
Research Article Neuroscience
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A novel optical microscope for imaging large embryos and tissue volumes with sub-cellular resolution throughout

A new type of microscope reveals detail of organelles inside every cell in the entirety of an intact embryo or tissue region over 100 cubic millimeters in volume.
  • Gail McConnell
  • Johanna Trägårdh
  • Rumelo Amor
  • John Dempster
  • Es Reid
  • William Bradshaw Amos
10.7554/eLife.18659
Research Article Neuroscience Developmental Biology and Stem Cells
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Seipin is required for converting nascent to mature lipid droplets

Seipin oligomers dynamically interact with small, nascent lipid droplets near the endoplasmic reticulum to convert them into larger, mature lipid droplets in a newly identified step of lipid droplet formation.
  • Huajin Wang
  • Michel Becuwe
  • Benjamin E Housden
  • Chandramohan Chitraju
  • Ashley J Porras
  • Morven M Graham
  • Xinran N Liu
  • Abdou Rachid Thiam
  • David B Savage
  • Anil K Agarwal
  • Abhimanyu Garg
  • Maria-Jesus Olarte
  • Qingqing Lin
  • Florian Fröhlich
  • Hans Kristian Hannibal-Bach
  • Srigokul Upadhyayula
  • Norbert Perrimon
  • Tomas Kirchhausen
  • Christer S Ejsing
  • Tobias C Walther
  • Robert V Farese Jr
10.7554/eLife.16582
Research Article Cell Biology
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Odd-paired controls frequency doubling in Drosophila segmentation by altering the pair-rule gene regulatory network

The organisation of the Drosophila embryo into segmental units is orchestrated by combinatorial regulatory interactions between spatially patterned and temporally patterned transcription factors.
  • Erik Clark
  • Michael Akam
10.7554/eLife.18215
Research Article Computational and Systems Biology Developmental Biology and Stem Cells
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Dissecting the pre-placodal transcriptome to reveal presumptive direct targets of Six1 and Eya1 in cranial placodes

RNA sequencing of the African clawed frog has identified hundreds of putative direct Six1 and Eya1 target genes, including transcriptional regulators of neuronal progenitors and neuronal/sensory differentiation.
  • Nick Riddiford
  • Gerhard Schlosser
10.7554/eLife.17666
Research Article Developmental Biology and Stem Cells
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Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis

PASK phosphorylates Wdr5 to trigger epigenetic changes at lineage specifying promoters resulting in transcriptional derepression and differentiation of stem or progenitor cells.
  • Chintan K Kikani
  • Xiaoying Wu
  • Litty Paul
  • Hana Sabic
  • Zuolian Shen
  • Arvind Shakya
  • Alexandra Keefe
  • Claudio Villanueva
  • Gabrielle Kardon
  • Barbara Graves
  • Dean Tantin
  • Jared Rutter
10.7554/eLife.17985
Research Article Biochemistry Developmental Biology and Stem Cells
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A robust activity marking system for exploring active neuronal ensembles

A new system for tagging activated neuronal population offers multiple advantages over existing systems based on immediate early genes, including greater sensitivity and specificity, and suitability for easy application in species other than mice.
  • Andreas T Sørensen
  • Yonatan A Cooper
  • Michael V Baratta
  • Feng-Ju Weng
  • Yuxiang Zhang
  • Kartik Ramamoorthi
  • Robin Fropf
  • Emily LaVerriere
  • Jian Xue
  • Andrew Young
  • Colleen Schneider
  • Casper René Gøtzsche
  • Martin Hemberg
  • Jerry CP Yin
  • Steven F Maier
  • Yingxi Lin
10.7554/eLife.13918
Tools and Resources Neuroscience
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A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading

A lysine-to-methionine mutation in histone H3 dominantly blocks histone H3K9 methylation by trapping its methyltransferase.
  • Chun-Min Shan
  • Jiyong Wang
  • Ke Xu
  • Huijie Chen
  • Jia-Xing Yue
  • Stuart Andrews
  • James J Moresco
  • John R Yates III
  • Peter L Nagy
  • Liang Tong
  • Songtao Jia
10.7554/eLife.17903
Research Article Genes and Chromosomes
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