Latest research

1. 1. Developmental Biology

   Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice

   Fabienne Benz et al.

   Endothelial tightening by augmenting low level Wnt/β-catenin activity in vessels of the mouse subfornical organ, influences neuronal activation in water-deprived mice, linking endothelial barrier properties to neuro-vascular coupling.
2. 1. Structural Biology and Molecular Biophysics

   Binding and transport of D-aspartate by the glutamate transporter homolog Glt_Tk

   Valentina Arkhipova et al.

   Glutamate transporter homologs can efficiently bind and transport both L- and D- enantiomeric substrates with only slight rearrangements in the binding site.
3. 1. Neuroscience

   Optogenetic dissection of basolateral amygdala contributions to intertemporal choice in young and aged rats

   Caesar M Hernandez et al.
4. 1. Neuroscience

   Mutant huntingtin enhances activation of dendritic Kv4 K⁺ channels in striatal spiny projection neurons

   Luis Carrillo-Reid et al.

   In mouse models of Huntington's disease, striatal spiny projection neurons up-regulate dendritic potassium channels, which impairs their normal function, but a zinc finger gene therapy can reverse this deficit.
5. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Novel RNA and DNA strand exchange activity of the PALB2 DNA Binding Domain and its critical role for DNA repair in cells

   Jaigeeth Deveryshetty et al.
6. 1. Microbiology and Infectious Disease

   Francisella tularensis enters a double membraned compartment following cell-cell transfer

   Shaun P Steele et al.
7. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Gene activation by a CRISPR-assisted trans enhancer

   Xinhui Xu et al.

   Both exogenous and endogenous genes can be highly activated in cells by a new dCas9-based activator, CRISPR-assisted trans enhancer, that can be used to activate genes for biomedical applications.
8. 1. Biochemistry and Chemical Biology

   A bacterial riboswitch class for the thiamin precursor HMP-PP employs a terminator-embedded aptamer

   Ruben M Atilho et al.

   Many bacteria use a tiny riboswitch aptamer to sense the thiamin precursor HMP-PP to regulate the production of another thiamin precursor HET-P to efficiently biosynthesize this essential coenzyme.
9. 1. Cancer Biology
   2. Immunology and Inflammation

   CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors

   Andrea Walens et al.

   CCL5-dependent macrophage recruitment drives breast cancer recurrence through collagen deposition in residual tumors.
10. 1. Genetics and Genomics

    Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage

    Angela Schulz et al.

    Genetic and functional studies reveal a previously unrecognized role for a transmembrane protein in glomerular filtration barrier function.