Latest research

1. 1. Ecology

   Rapid spread of a densovirus in a major crop pest following wide-scale adoption of Bt-cotton in China

   Yutao Xiao et al.

   Exposure to Bacillus thuringiensis (Bt) selects for beneficial interactions between the target insect pest (Helicoverpa armigera) and its symbiotic densovirus that enhances its performance on Bt-crops under field conditions.
2. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Role of BRCA2 DNA-binding and C-terminal domain in its mobility and conformation in DNA repair

   Maarten W Paul et al.

   Highly conserved C-terminal domains of the tumor suppressor BRCA2 are not essential for accumulation at damaged DNA but affect conformation and cell survival, implying roles beyond delivering strand-exchange protein RAD51.
3. 1. Microbiology and Infectious Disease

   A novel decoy strategy for polymyxin resistance in Acinetobacter baumannii

   Jaeeun Park et al.

   Outer membrane vesicles serve as decoys to reduce the chance of direct polymyxin B (PMB) binding to cells, which partly explains why many clinical isolates and microbial communities can be protected against PMB treatment.
4. 1. Cell Biology

   CDK1 controls CHMP7-dependent nuclear envelope reformation

   Alberto T Gatta et al.

   CHMP7 is phosphorylated by CDK1 upon mitotic entry, preventing interaction with LEM2 and inappropriate assembly during mitotic exit.
5. 1. Immunology and Inflammation
   2. Medicine

   Expansion of CD10^neg neutrophils and CD14⁺HLA-DR^neg/low monocytes driving proinflammatory responses in patients with acute myocardial infarction

   Daniela Fraccarollo et al.

   Immature CD10^neg neutrophils and CD14⁺HLA-DR^neg/low monocytes inducing proinflammatory and adaptive immune responses emerge in patients with large acute myocardial infarction.
6. 1. Neuroscience

   Unsupervised changes in core object recognition behavior are predicted by neural plasticity in inferior temporal cortex

   Xiaoxuan Jia et al.

   Temporal continuity-induced plasticity in individual neurons of inferior temporal cortex builds neural representations that underlie robust core object recognition behavior.
7. 1. Genetics and Genomics
   2. Neuroscience

   Neuropeptide ACP facilitates lipid oxidation and utilization during long-term flight in locusts

   Li Hou et al.

   CRISPR/Cas 9 technology and multiple-omics study reveal an essential regulatory role of neuropeptide ACP in lipid utilization related to prolonged flight of locusts.
8. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Genetically incorporated crosslinkers reveal NleE attenuates host autophagy dependent on PSMD10

   Jingxiang Li et al.

   Transient interactions between NleE and PMSD10 suppress PSMD10 interaction with ATG7 to attenuate host autophagosome formation.
9. 1. Evolutionary Biology
   2. Structural Biology and Molecular Biophysics

   Structurally distributed surface sites tune allosteric regulation

   James W McCormick et al.

   Deep mutational scanning of a synthetic allosteric chimera revealed that a sparse set of mutations on the protein surface improved regulation.
10. 1. Neuroscience

    Multiple neuronal networks coordinate Hydra mechanosensory behavior

    Krishna N Badhiwala et al.

    Despite lacking traditional ganglia or centralization, the Hydra nervous system computes sensorimotor responses via localized neuron ensembles.