Highlights

  • T-cells target TB-infected cells

    Complementary human in vitro systems suggest a non-classical T-cell pathway contributing to immunity against Mycobacterium tuberculosis infection

    Matthew Milton, Sahar H Farag ... Salah Mansour
    Reviewed Preprint Updated

  • Mapping Regulatory DNA

    Cis-regulatory elements in the large genome of Parhyale hawaiensis can be identified by integrating chromatin accessibility and sequence conservation data.

    Gillian Forbes, Emilia Skafida ... Mathilde Paris
    Reviewed Preprint Updated

  • Hypoxia to healthspan

    Genetic tools highlight potential signalling components underlying hypoxia-induced longevity in C. elegans.

    Elizabeth S Kitto, Shijiao Huang ... Scott F Leiser
    Reviewed Preprint Updated

  • Publish-review-curate at eLife

    eLife is rethinking how research is reviewed and published.

    Timothy E Behrens, Yamini Dalal, Diane M Harper
    Editorial

  • AI in research communication

    eLife has partnered on a number of projects harnessing AI for improving human and machine reader engagement with research.

    Inside eLife

  • Science under threat

    How should the scientific community respond to ideological attacks on science?

    Humberto J Debat
    Feature Article
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Developmental Biology
    2. Evolutionary Biology

    The tuxedo sea urchin Mespilia globulus: A fast-developing and tractable model for genomic and developmental biology

    Omar Matar, Marie Emilie Maeland ... Ferdinand Marlétaz
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Evolutionary Biology

    Parallel connectivity and genomic divergence but heterogeneous demographic history in sympatric Mediterranean clingfishes

    Maximilian Wagner, Stephan Koblmüller ... Hannes Svardal
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Biochemistry and Chemical Biology

    Lateral opening site of human oligopeptide transporter 2 plays a key role in the interaction with polymyxins

    Xukai Jiang, Yining Luo ... Jian Li
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Developmental Biology

    Spectraplakin is required for dendritic microtubule organization via a tip-based mechanism

    Matthew Davies, Neeraja Sanal ... Sebastian Rumpf
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Ecology
    2. Neuroscience

    Machine learning of honey bee olfactory behavior identifies repellent odorants in free-flying bees in the field

    Joel Kowalewski, Barbara F Baer-Imhoof ... Anandasankar Ray
    Honey bee olfactory aversion can be modeled using machine learning to iteratively discover bee-selective repellents, validated in free-flying assays, that can potentially reduce contact with pesticides.
    Version of Record
    Short Report
    • Important
    • Solid
    1. Neuroscience

    Region-specific mechanosensation modulates Drosophila postural control behaviour

    William Roseby, Jonathan AC Menzies ... Claudio R Alonso
    Behavioural, optogenetic, and gene expression analyses demonstrate that regional mechanosensory processes instructed by Hox gene inputs are essential for postural control in Drosophila larvae linking local body features to behaviour.
    1. Microbiology and Infectious Disease

    Identifying a novel mechanism of L-leucine uptake in Mycobacterium tuberculosis using a chemical genomic approach

    Nisheeth Agarwal, Himanshu Gogoi ... Bappaditya Dey
    A well-orchestrated machinery for L-leucine uptake is functional in Mycobacterium tuberculosis, which is important for the intracellular survival of the tuberculosis (TB) pathogen.
    1. Neuroscience

    Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep

    Lin Yan, Litao Wu ... Chang Liu
    A state-dependent inhibitory dopaminergic microcircuit co-regulates sleep and long-term memory via distinct signaling cascades.
    1. Microbiology and Infectious Disease

    A novel rapid host cell entry pathway determines the intracellular fate of Staphylococcus aureus

    Marcel Rühling, Fabio Schmelz ... Martin J Fraunholz
    An acid sphingomyelinase-dependent rapid uptake pathway for the pathogen Staphylococcus aureus is linked to altered intracellular infection dynamics.
    1. Cancer Biology

    Microbial Metabolites Potentiate MAIT Cell Anti-Tumor Immunity Against Solid Tumors

    Yichen Zhu, Xinyuan Shen ... Lili Yang
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
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Magazine

  1. Close-up of an iris

    Episode 105: September 2026

    1. Cell Biology
    2. Computational and Systems Biology

    Philosophy of Biology: The power of theory in the life sciences

    Jacob L Fine, Finn Creeggan ... Adam MR Groh
    1. Genetics and Genomics

    Environmental Learning: How experience shapes individuality

    Bassem A Hassan

  4. Point of View: Scientific writing is not a murder mystery

    Charlotte A Dodson
    1. Neuroscience

    Visual Categorization: How monkeys carve up the visual world

    Binxu Wang
    1. Cell Biology

    Stress: How to give cells an identity crisis

    Paige Dillon, Julie Hollien
    1. Epidemiology and Global Health

    Malaria Prevention: Using mathematical models to optimise mosquito net distribution

    Carlos A Prete Jr
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Categories

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