Latest research

1. 1. Biochemistry and Chemical Biology
   2. Medicine

   The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans

   Omar Al Rifai et al.

   In mice, but not in humans, the bone-derived hormone osteocalcin is O-glycosylated, a post-translational modification controlling its half-life in vivo.
2. 1. Cancer Biology
   2. Cell Biology

   Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes

   Shima Ghoroghi et al.

   A combination of animal models reveal how the molecular mechanisms of exosome secretion (RalA/B-dependent) are linked to their cargo content and their function in breast cancer pre-metastatic niche formation.
3. 1. Stem Cells and Regenerative Medicine

   Scleraxis-lineage cell depletion improves tendon healing and disrupts adult tendon homeostasis

   Katherine T Best et al.
4. 1. Cell Biology

   Optogenetic control of PRC1 reveals its role in chromosome alignment on the spindle by overlap length-dependent forces

   Mihaela Jagrić et al.
5. 1. Cell Biology

   Cross-compartment signal propagation in the mitotic exit network

   Xiaoxue Zhou et al.

   The mitotic exit network signals from spindle pole bodies to the nucleolus through the dynamic localization of its terminal kinase complex Dbf2-Mob1.
6. 1. Developmental Biology

   Runx2-Twist1 interaction coordinates cranial neural crest guidance of soft palate myogenesis

   Xia Han et al.

   Identification of heterogenous cranial neural crest (CNC)-derived cell populations and their roles in guiding craniofacial muscle development through cell-cell interactions.
7. 1. Immunology and Inflammation
   2. Structural Biology and Molecular Biophysics

   Properdin oligomers adopt rigid extended conformations supporting function

   Dennis V Pedersen et al.
8. 1. Structural Biology and Molecular Biophysics

   Structural basis for transcription complex disruption by the Mfd translocase

   Jin Young Kang et al.
9. 1. Developmental Biology

   Reciprocal interaction between mesenchymal stem cells and transit amplifying cells regulates tissue homeostasis

   Junjun Jing et al.

   The molecular regulatory mechanisms that control the interaction between mesenchymal stem cells and transit amplifying cells to maintain tissue homeostasis.
10. 1. Evolutionary Biology
    2. Genetics and Genomics

    Universal and taxon-specific trends in protein sequences as a function of age

    Jennifer E James et al.

    Ancient protein domains remain shaped by amino acid availability during early life, while young animal proteins are shaped by a need for high intrinsic structural disorder.