Microscopy versus malaria

Latest research

1. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to antifungal compounds

   Vanessa Dumeaux, Samira Massahi ... Michael T Hallett

   Candida albicans cells respond in two distinct ways to fluconazole exposure where cells enter the Ribo-dominant state characterized by an upregulation of ribosomal-related proteins and processes, or cells enter the Stress-dominant state characterized by the upregulation of stress responses.
2. 1. Evolutionary Biology
   2. Genetics and Genomics

   Down the Penrose stairs, or how selection for fewer recombination hotspots maintains their existence

   Zachary Baker, Molly Przeworski, Guy Sella

   Modeling the evolution of PRDM9 in light of recent results implicating the importance of PRDM9 binding symmetry suggests the advantage of new PRMD9 alleles is in limiting the number of binding sites used effectively rather than increasing net binding.
3. 1. Immunology and Inflammation

   Pulsed ultrasound promotes secretion of anti-inflammatory extracellular vesicles from skeletal myotubes via elevation of intracellular calcium level

   Atomu Yamaguchi, Noriaki Maeshige ... Hidemi Fujino

   Ultrasound promotes release of extracellular vesicles from cultured myotubes and elicits anti-inflammatory effects on macrophages, indicating the potential of ultrasound stimulation to muscle for anti-inflammatory purposes.
4. 1. Physics of Living Systems

   A unified approach to dissecting biphasic responses in cell signalling

   Vaidhiswaran Ramesh, J Krishnan
5. 1. Neuroscience

   Modeling apical and basal tree contribution to orientation selectivity in a mouse primary visual cortex layer 2/3 pyramidal cell

   Konstantinos-Evangelos Petousakis, Ji Young Park ... Panayiota Poirazi
6. 1. Neuroscience
   2. Structural Biology and Molecular Biophysics

   Dynamic landscape of the intracellular termini of acid-sensing ion channel 1a

   Megan M Cullinan, Robert C Klipp ... John R Bankston

   A novel FRET approach suggests that the intracellular termini of acid-sensing ion channel 1a do not form a complex at rest requiring a new hypothesis for ASIC1a involvement in stroke.
7. 1. Neuroscience

   Adaptive biasing of action-selective cortical build-up activity by stimulus history

   Anke Braun, Tobias H Donner

   Prior expectations about the state of the sensory environment are dynamically updated in a context-dependent manner and selectively bias the build-up of human motor cortical activity during subsequent decisions.
8. 1. Structural Biology and Molecular Biophysics

   Folding of prestin’s anion-binding site and the mechanism of outer hair cell electromotility

   Xiaoxuan Lin, Patrick R Haller ... Tobin R Sosnick

   Identification of Cl⁻-induced folding advances the field’s understanding of prestin’s unique voltage-sensing mechanism and its involvement in mammalian hearing sensation.
9. 1. Genetics and Genomics
   2. Immunology and Inflammation

   Sustained store-operated calcium entry utilizing activated chromatin state leads to instability in iTregs

   Huiyun Lyu, Guohua Yuan ... Yan Shi

   Multidimensional study of signaling pathways and epigenomics investigates how TCR (T cell receptor) signaling and chromatin landscape interpaly and impact on Treg stability.
10. 1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Apoptotic signaling clears engineered Salmonella in an organ-specific manner

    Taylor J Abele, Zachary P Billman ... Edward A Miao

    Clearance of engineered Salmonella which trigger regulated cell death is dependent upon the cellular 'bucket list,' which is determined both by cell death signaling pathway and by cell type infected.