• ERK3 in control

    The kinase ERK3 influences the motility of tumor cells by controlling a previously unknown regulatory pathway.

    Katarzyna Bogucka-Janczi, Gregory Harms ... Krishnaraj Rajalingam
    Research Advance Updated
  • Seeing MHC activation in vivo

    MHC reporter mice can be used to analyse inflammation and neurodegeneration, and to study diseases such as multiple sclerosis.

    Em P Harrington, Riley B Catenacci ... Peter A Calabresi
    Tools and Resources Updated
  • Update on eLife’s new model

    In the first three months, we have seen consistent submissions and positive feedback from authors.

    Inside eLife

Latest research

    1. Medicine

    Axonal T3 uptake and transport can trigger thyroid hormone signaling in the brain

    Federico Salas-Lucia, Csaba Fekete ... Antonio C Bianco
    T3 is taken up by axonal termini and is retrogradely transported into endosomal vesicles to the cell nucleus, where it regulates gene expression.
    1. Neuroscience

    Motor cortex analogue neurons in songbirds utilize Kv3 channels to generate ultranarrow spikes

    Benjamin M Zemel, Alexander A Nevue ... Henrique von Gersdorff
    Molecular and electrophysiological evidence shows that Kv3 subunits contribute critically to ultrashort action potential waveforms and high-frequency firing in large projection neurons in zebra finch motor nuclei controlling song production and somatic movements.
    1. Neuroscience

    Response outcome gates the effect of spontaneous cortical state fluctuations on perceptual decisions

    Davide Reato, Raphael Steinfeld ... Alfonso Renart
    In a forced-choice auditory discrimination task, mice are more accurate if neural activity in the auditory cortex in the pre-stimulus baseline is higher and more desynchronized, but only if the previous trial was an error.
    1. Neuroscience

    Humans parsimoniously represent auditory sequences by pruning and completing the underlying network structure

    Lucas Benjamin, Ana Fló ... Ghislaine Dehaene-Lambertz
    When exposed to sound sequences, humans compute biased transition probabilities between elements, extract the underlying network structure, and even generalize missing data.
    1. Neuroscience

    Making memories last using the peripheral effect of direct current stimulation

    Alison M Luckey, Lauren S McLeod ... Sven Vanneste
    Non-invasive transcutaneous electrical stimulation of the greater occipital nerve using direct current promotes strengthening of memories using late-phase synaptic activity.
    1. Neuroscience

    Gain, not concomitant changes in spatial receptive field properties, improves task performance in a neural network attention model

    Kai J Fox, Daniel Birman, Justin L Gardner
    Simple modifications to early stages of the visual hierarchy, such as gain changes, can induce complex effects on later stages, but only gain is both necessary and sufficient to explain enhanced perception during spatial attention.
    1. Cell Biology

    Annexin A6 mediates calcium-dependent exosome secretion during plasma membrane repair

    Justin Krish Williams, Jordan Matthew Ngo ... Randy Schekman
    Plasma membrane damage causes the release of exosomes from cultured human cells.
    1. Microbiology and Infectious Disease

    Structure–function analysis of Lactiplantibacillus plantarum DltE reveals D-alanylated lipoteichoic acids as direct cues supporting Drosophila juvenile growth

    Nikos Nikolopoulos, Renata C Matos ... François Leulier
    D-alanylated lipoteichoic acids support Drosophila juvenile growth.
    1. Neuroscience

    Toward a more informative representation of the fetal–neonatal brain connectome using variational autoencoder

    Jung-Hoon Kim, Josepheen De Asis-Cruz ... Catherine Limperopoulos
    A nonlinear deep generative model can represent fetal–neonatal resting-state functional magnetic resonance imaging better than conventional linear models.
    1. Cell Biology

    Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis

    Devon E. Mason, Megan Goeckel ... Joel D. Boerckel