Latest research

1. 1. Ecology

   Eco-evolutionary dynamics modulate plant responses to global change depending on plant diversity and species identity

   Peter Dietrich et al.

   Offspring of plants selected at low and high plant diversity differently respond to global change drivers (nitrogen enrichment, drought), as reflected by their biomass production and trait expression, whereby plant-soil interactions play a significant role in these processes.
2. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Rate-limiting transport of positively charged arginine residues through the Sec-machinery is integral to the mechanism of protein secretion

   William J Allen et al.

   The time it takes to secrete a protein is dominated by diffusion of positively charged arginines through the channel across the membrane, but lysines avoid this problem as they are neutralised before transport.
3. 1. Neuroscience

   Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse

   Amy Richardson et al.

   The Kv3.3 potassium channel subunit is necessary and sufficient to permit presynaptic location and accelerated repolarisation of the presynaptic action potential, thereby conserving resources and enhancing accuracy of timing information on transmission at the calyx of Held excitatory synapse.
4. 1. Neuroscience

   Drosophila nicotinic acetylcholine receptor subunits and their native interactions with insecticidal peptide toxins

   Dagmara Korona et al.

   Blocking of the function of neurotransmitter receptors by insecticidal peptide toxins resulted in identification of nicotinic acetylcholine receptor subunits through native ligand-binding investigations.
5. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells

   David J Hosfield et al.
6. 1. Cancer Biology
   2. Computational and Systems Biology

   Regulation of protein complex partners as a compensatory mechanism in aneuploid tumors

   Gökçe Senger et al.
7. 1. Chromosomes and Gene Expression

   DNA-PK promotes DNA end resection at DNA double strand breaks in G₀ cells

   Faith C Fowler et al.
8. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Transcription elongation is finely tuned by dozens of regulatory factors

   Mary Couvillion et al.
9. 1. Evolutionary Biology

   Palatal morphology predicts the paleobiology of early salamanders

   Jia Jia et al.
10. 1. Genetics and Genomics
    2. Neuroscience

    Machine learning sequence prioritization for cell type-specific enhancer design

    Alyssa J Lawler et al.

    A new cross-species machine learning-based strategy is applied to find enhancers that specifically label parvalbumin neurons in the mouse and macaque.