eLife works to improve research communication through open science and open technology innovation

Latest research

    1. Neuroscience

    7-Dehydrocholesterol-derived oxysterols cause neurogenic defects in Smith-Lemli-Opitz syndrome

    Hideaki Tomita, Kelly M Hines ... Libin Xu
    A 7-dehydrocholesterol-derived oxysterol in SLOS was found to profoundly impact neurogenesis during cortical development by interacting with glucocorticoid receptor, which points to new therapeutic approaches for SLOS by targeting the activities of this oxysterol.
    1. Developmental Biology

    A neurogenic signature involving monoamine Oxidase-A controls human thermogenic adipose tissue development

    Javier Solivan-Rivera, Zinger Yang Loureiro ... Silvia Corvera
    A hybrid mouse/human model using mesenchymal progenitor cells reveals dynamics of human adipose tissue development and mechanisms that may enhance human adipose thermogenic capacity.
    1. Developmental Biology

    Murine blastocysts generated by in vitro fertilization show increased Warburg metabolism and altered lactate production

    Seok Hee Lee, Xiaowei Liu ... Paolo F Rinaudo
    In vitro fertilization-conceived murine embryos show evidence of oxidative and metabolic stress with alteration in lactic acid metabolism.
    1. Neuroscience

    Distinct population and single-neuron selectivity for executive and episodic processing in human dorsal posterior cingulate

    Lyndsey Aponik-Gremillion, Yvonne Y Chen ... Brett L Foster
    Invasive recordings from human dorsal posterior cingulate cortex show neural population responses occur for only executive tasks, while single neuron responses occur for specific executive or episodic cognitive tasks.
    1. Cell Biology

    Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1

    Meng Zhao, Niels Banhos Dannieskiold-Samsøe ... Katrin J Svensson
    1. Chromosomes and Gene Expression

    The SPARC complex defines RNAPII promoters in Trypanosoma brucei

    Desislava P Staneva, Stefan Bresson ... Robin C Allshire
    1. Neuroscience

    Flexing the principal gradient of the cerebral cortex to suit changing semantic task demands

    Zhiyao Gao, Li Zheng ... Elizabeth Jefferies
    1. Developmental Biology
    2. Neuroscience

    Plexins promote hedgehog signaling through their cytoplasmic GAP activity

    Justine M Pinskey, Tyler M Hoard ... Benjamin L Allen