Highlights

  • Deep mutational scanning

    High-resolution approach has been used to assess the effect of more than 6000 protein-coding variants in a G protein-coupled receptor associated with obesity.

    Conor J Howard, Nathan S Abell ... Nathan B Lubock
    Reviewed Preprint Updated
  • eLife wins award for UX

    eLife wins user experience (UX) award from OpenAthens for its user-driven approach to the design of Reviewed Preprints.

    Press Pack
  • Social behaviors in mice

    A cell atlas for the preoptic area of the brain could be used to investigate how neuronal traits may be evolving to give rise to innate differences in social behavior across species.

    Jenny Chen, Phoebe R Richardson ... Hopi E Hoekstra
    Reviewed Preprint Updated

Latest research

    1. Developmental Biology

    Probing metazoan polyphosphate biology using Drosophila reveals novel and conserved polyP functions

    Sunayana Sarkar, Harsha Sharma ... Manish Jaiswal
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Computational and Systems Biology

    Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism

    David Dierks, Ran Shachar ... Schraga Schwartz
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Neuroscience

    Serotonin modulates infraslow oscillation in the dentate gyrus during Non-REM sleep

    Gergely F Turi, Sasa Teng ... Yueqing Peng
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Distinct adaptation and epidemiological success of different genotypes within Salmonella enterica serovar Dublin

    Cheryll M Sia, Rebecca L Ambrose ... Danielle J Ingle
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Neuroscience

    A gradual transition toward categorical representations along the visual hierarchy during working memory, but not perception

    Chaipat Chunharas, Michael J Wolff ... Rosanne L Rademaker
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Stimulus representation in human frontal cortex supports flexible control in working memory

    Zhujun Shao, Mengya Zhang, Qing Yu
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Compelling
    1. Cell Biology
    2. Developmental Biology

    The full length BEND2 protein is dispensable for spermatogenesis but required for setting the ovarian reserve in mice

    Yan Huang, Nina Bucevic ... Ignasi Roig
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Developmental Biology

    Contribution of the epididymis beyond fertilization: relevance of CRISP1 and CRISP3 for sperm DNA integrity and early embryo development

    Valeria Sulzyk, Ludmila Curci ... Patricia S Cuasnicu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Immunology and Inflammation

    Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions

    Sytse J Piersma, Shasha Li ... Wayne M Yokoyama
    A novel mouse model offers definitive evidence that a single inhibitory receptor family governs the critical natural killer cell functions of licensing and missing-self.
    1. Neuroscience

    Microprism-based two-photon imaging of the mouse inferior colliculus reveals novel organizational principles of the auditory midbrain

    Baher A Ibrahim, Yoshitaka Shinagawa ... Daniel A Llano
    A new method to image the lateral surface of midbrain revealed novel organization of the lateral cortex of the inferior colliculus of the mouse.