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Latest research

    1. Cancer Biology
    2. Chromosomes and Gene Expression

    CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor-targeting therapies

    Justin H Hwang et al.
    A comprehensive molecular interrogation of CREB5 interactions identified changes in protein and chromatin interactions of FOXA1 that promoted therapy resistance in prostate cancer cells.
    1. Cancer Biology
    2. Computational and Systems Biology

    Regulation of protein complex partners as a compensatory mechanism in aneuploid tumors

    Gökçe Senger et al.
    Coordinated regulation of co-complex members compensates for aneuploidy-induced stoichiometric imbalances in human cancer.
    1. Immunology and Inflammation
    2. Neuroscience

    Single-cell profiling reveals periventricular CD56bright NK cell accumulation in multiple sclerosis

    Sabela Rodríguez-Lorenzo et al.
    Together, our multi-tissue single-cell data shows that CD56bright NK cells accumulate in the periventricular brain regions of multiple sclerosis (MS) patients, bringing NK cells back to the spotlight of MS pathology.
    1. Cell Biology

    CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression

    Désirée Schatton et al.
    CLUH links growth signaling pathways and mitochondrial metabolism with cell cycle progression by regulating astrin-1 synthesis and stability.
    1. Neuroscience

    A dynamic clamp protocol to artificially modify cell capacitance

    Paul Pfeiffer et al.
    Via the capacitance clamp, electrophysiologists can for the first time flexibly set an artificial membrane capacitance for neurons and other excitable cells and thereby adjust their membrane time constant independent of any conductance changes.
    1. Neuroscience

    Eye movements reveal spatiotemporal dynamics of visually-informed planning in navigation

    Seren Zhu et al.
    The spatial and temporal patterns of eye movements exhibited by humans in virtual reality reveal how they plan paths when navigating in complex, naturalistic environments.
    1. Structural Biology and Molecular Biophysics

    Deciphering a hexameric protein complex with Angstrom optical resolution

    Hisham Mazal et al.
    Cryogenic super-resolution microscopy resolves the three-dimensional arrangement of individual fluorescent markers attached to protein complexes with Angstrom precision through their blinking behavior, polarization selection and a classification scheme.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Hybridization alters the shape of the genotypic fitness landscape, increasing access to novel fitness peaks during adaptive radiation

    Austin H Patton et al.
    Hybridization not only generates genetic diversity, but this diversity can alter the shape of the fitness landscape, changing which genotypic combinations are favored by natural selection and which accessible genotypic paths lead to novel fitness peaks.