Browse the latest research

19,124 results found
    1. Cell Biology

    Sequential adaptor function of Treacle and MDC1 couples nucleolar reorganization to RNF8-dependent recruitment of HDR factors

    Andrea Haenel, Johannes Leyrer ... Manuel Stucki
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Ecology

    The overall and sequence-specific degradation of soil extracellular DNA fragments: rates and influential factors

    Ting Li, Song Zhang ... Rongxiao Che
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Cell Biology

    p66Shc Mediates SUMO2-induced Endothelial Dysfunction

    Jitendra Kumar, Shravan K Uppulapu ... Santosh Kumar
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    • Solid
    1. Developmental Biology
    2. Cancer Biology

    A Rare Nestin-Expressing Granule Cell Precursor Subpopulation Underlies SHH Medulloblastoma Formation

    Salsabiel El Nagar, Yinwen Liang ... Alexandra L Joyner
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Combinatorial transcription factor interactions drive modular gene regulatory networks

    Jialei Duan, Boxun Li ... Gary C Hon
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Immunology and Inflammation

    Tolerance to Lung Infection in TWIK2 K+ Efflux Mediated Macrophage Trained Immunity

    Josh Thompson, Yufan Li ... Jingsong Xu
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Incomplete
    1. Cell Biology

    SETD6-mediated methylation of PPARγ establishes a transcriptional feedback circuit promoting lipid accumulation in liver-derived cells

    Noa Nashnaz, Dana Goldberg ... Dan Levy
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Stem Cells and Regenerative Medicine

    Endometrial cells with high ALDH activity contribute to uterine development and regeneration

    Suni Tang, Anna Catherine Unser ... Diana Monsivais
    ALDH1A1+ cells are a group of hormone-sensitive stem cells that contribute to endometrial development and repair.
    1. Neuroscience

    LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics

    Giulia Tombesi, Shiva Kompella ... Elisa Greggio
    LRRK2 couples brain-derived neurotrophic factor (BDNF) signaling to synaptic actin remodeling, defining a novel mechanism of LRRK2 synaptic function and highlighting early, targetable pathways in Parkinson’s disease.
    1. Microbiology and Infectious Disease

    Nanoscopy reveals heparan sulfate clusters as docking sites for SARS-CoV-2 attachment and entry

    Sue Han, Xin Wang ... Ling-Gang Wu
    Cell-surface heparan sulfate clusters, not the generally assumed ACE2, mediate SARS-CoV-2 attachment and endocytic entry, fundamentally revising the viral entry paradigm and establishing heparan sulfate as a primary therapeutic target.

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