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18,503 results found
    1. Cell Biology

    Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (p97-PROTAC)

    Constanza Salinas-Rebolledo, Javier Blesa ... Alejandro Rojas-Fernandez
    Synthetic adaptors combining camelid nanobodies with the UBX domain of the p97 adaptor FAF1 enable targeted substrate delivery to p97, establishing an E3 ubiquitin ligase-independent mechanism for selective protein degradation.
    1. Neuroscience

    How individual vigor shapes human-human physical interaction

    Dorian Verdel, Bastien Berret, Etienne Burdet
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Computational and Systems Biology

    Targeted Computational Design of an Interleukin-7 Superkine with Enhanced Folding Efficiency and Immunotherapeutic Efficacy

    See-Khai Lim, Wen-Ching Lin ... Kurt Yun Mou
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Dynamic updating of spatial working memory across eye movements: a computational investigation of transsaccadic integration

    Sijia Zhao, Thomas Parr ... Masud Husain
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Developmental Biology
    2. Neuroscience

    From Syllables to Words: EEG Evidence of Different Age Trajectories in Speech Tracking and Statistical Learning in Infants at High and Low Likelihood for Autism

    Michel Godel, Ana Fló ... Marie Schaer
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology

    JAK-STAT pathway activation compromises nephrocyte function in a Drosophila high-fat diet model of chronic kidney disease

    Yunpo Zhao, Jianli Duan ... Zhe Han
    A conserved signaling axis linking Drosophila adipose tissue to nephrocyte function reveals how obesity can drive kidney dysfunction and points to new opportunities for therapeutic intervention.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Neisseria gonorrhoeae LIN codes provide a robust, multi-resolution lineage nomenclature

    Anastasia Unitt, Made A Krisna ... Odile B Harrison
    LIN code offers a reliable framework for classifying gonococcal population structure, enabling straightforward exploration of isolate relationships, from broad superlineage divisions to minute single allele differences.
    1. Physics of Living Systems

    The evolution of interdisciplinarity and internationalization in scientific journals

    Huaxia Zhou, Luis A Nunes Amaral
    Analysis of ~50 million articles published in ~50 thousand journals demonstrates that journals have become more diverse in terms of both interdisciplinarity and internationalization but with some disciplinary differences.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Hybridization breaks species barriers in long-term coevolution of a cyanobacterial population

    Gabriel Birzu, Harihara Subrahmaniam Muralidharan ... Devaki Bhaya
    Analysis of hundreds of single-cell genomes from Yellowstone National Park shows bacterial species are less cohesive than previously thought.
    1. Neuroscience

    Decision-making components and times revealed by the single-trial electroencephalogram

    Gabriel Weindel, Jelmer P Borst, Leendert van Maanen
    By modeling the single-trial electroencephalogram of participants performing perceptual decisions, and building on predictions from two century-old psychological laws, we estimate the times of information processing steps contained in decision-making.
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