Browse the latest research

19,263 results found
    1. Physics of Living Systems

    A unifying model of T-cell signaling protein condensates in reconstitution experiments

    Yannick Azhri Din Omar, Simou Sun ... Arup K Chakraborty
    The formation of biomolecular condensates by multivalent membrane proteins is delayed by slow crosslinking dynamics, with a variety of condensate morphologies emerging under different experimental conditions.
    1. Neuroscience

    Pathogenic O-GlcNAc dyshomeostasis is associated with cortical malformations and hyperactivity

    Florence Authier, Asad Jan ... Daan MF van Aalten
    A mouse model of O-GlcNAc transferase associated intellectual disability reveals brain structural and cognitive deficits providing an important platform for mechanistic and therapeutic discovery.
    1. Developmental Biology
    2. Genetics and Genomics

    PRMT1-SFPQ regulates intron retention to control matrix gene expression during craniofacial development

    Julia Raulino Lima, Nicha Ungvijanpunya ... Jian Xu
    IR-couple NMD controls matrix transcript abundance during craniofacial morphogenesis.
    1. Neuroscience

    Partial input loss differentially modifies neural pathways

    Joo Yeun Lee, Jeffrey Yang ... Felice A Dunn
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Computational and Systems Biology
    2. Cancer Biology

    MicroRNA spatial profiling for assessing drug efficacy in BRCA1-related triple-negative breast tumors

    Omar N Mohd, Lin Wang ... Patrick S Doyle
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    In vivo virus-free lineage tracing and live imaging reveal that NeuroD1 does not reprogram microglia into neurons

    Xiaoyu Li, Yuxin Li ... Yanxia Rao
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Immunology and Inflammation

    A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification

    Jordan Z Zhou, Bo Pei ... Kang Chen
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Neuroscience

    Strong mnemonic prediction errors increase cognitive control, attention, and arousal

    Alice M Xue, Jenna Jokhani ... Anthony D Wagner
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Immunology and Inflammation

    Heterogeneity and Ontogeny of Mouse Thymic Macrophages Reveal a Requirement for Csf1r-Expressing Myeloid Cells During Early T Cell Development

    Helen Wang, Vinothkumar Rajan ... Juan Carlos Zúñiga-Pflücker
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Medicine

    Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injury

    Yaying Zhu, Chengxiang Deng ... Zhao Shan
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    • Convincing
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