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19,192 results found
    1. Cell Biology

    Zasp52’s differentially expressed intrinsically disordered region confers thin filament stability at the Z-disc

    Nikolai Ho, Frieder Schöck
    The Z-disc of muscle sarcomeres is a solid aggregate stabilized by the intrinsically disordered region of the Alp/Enigma family protein Zasp52.
    1. Ecology
    2. Evolutionary Biology

    Evolution of sideways locomotion in crabs

    Junya Taniguchi, Tsubasa Inoue ... Yuuki Kawabata
    Sideways locomotion in true crabs likely originated once from a forward-moving ancestor, providing insight into how behavioral innovations shape evolutionary diversification.
    1. Cell Biology

    Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidification and rupture

    Jessica Tittelmeier, Carl Alexander Sandhof ... Carmen Nussbaum-Krammer
    Restoring endolysosomal membrane fluidity limits tau seed escape, seeded aggregation, and neuronal toxicity in cell and animal models.
    1. Biochemistry and Chemical Biology

    A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins

    Daniel J Kelpsch, Liyun Zhang ... Steven A Farber
    An in vivo small-molecule drug screen in developing zebrafish larvae identifies dozens of unique chemical modulators capable of reducing atherogenic apolipoprotein B levels.
    1. Neuroscience

    HSSM: A Widely Applicable Toolbox for Hierarchical Bayesian Neurocognitive Modeling

    Alexander Fengler, Yang Xu ... Michael J Frank
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Cell Biology
    2. Chromosomes and Gene Expression

    A genetic toolkit for stable transgenesis in the anaerobic gut parasite Blastocystis ST7-B

    M Rey Toleco, Kevin SW Tan, Mark van der Giezen
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Genetics and Genomics
    2. Evolutionary Biology

    Life-stage-specific specialities in the cell atlases of the Clytia hemisphaerica planula and medusa

    Anna Ferraioli, Julia Ramon Mateu ... Richard R Copley
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Immunology and Inflammation

    Simplifying principles underlying the highly complex peptide motif of the promiscuous chicken MHC class I molecule, BF2*21:01

    Michael Harrison, Paul E Chappell ... Jim Kaufman
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Cell Biology
    2. Neuroscience

    ATP8B1–TMEM30B Flippase Activity Maintains Stereocilia Lipid Asymmetry Required for Hearing

    Henry N De Hoyos, Sihan Li ... Jung-Bum Shin
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Neuroscience

    Non-decision time-informed collapsing threshold diffusion model: A joint modeling framework with identifiable time-dependent parameters

    Amir Hosein Hadian Rasanan, Lukas Schumacher ... Jörg Rieskamp
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
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