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18,916 results found
    1. Neuroscience

    Loose coupling between Ca2+ channels and release sensors as a synaptic correlate of higher order brain function

    Max Schwarze, Grit Bornschein ... Hartmut Schmidt
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    Two Glu/Asp Residues Cooperatively Mediate an Early Step of ATP Hydrolysis in GHKL ATPases MutL and GyrB

    Kenji Fukui, Ayaka Shibuya ... Takato Yano
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Neuroscience

    Inhibitory columnar feedback neurons are involved in motion processing in Drosophila

    Miriam Henning, Madhura D Ketkar ... Marion Silies
    Inhibitory GABAergic feedback neurons tune direction-selective motion signals in Drosophila, sharpening behavioral responses to rapidly changing visual stimuli and expanding canonical feedforward models of visual motion computation.
    1. Ecology
    2. Physics of Living Systems

    Cognitive simplicity drives collective route improvements in homing pigeons

    Shoubhik Chandan Banerjee, Fritz A Francisco, Albert B Kao
    A navigational model exploring social learning strategies differing in cognitive complexity in homing pigeons shows that simple averaging sufficiently explains collective route improvements, without requiring cumulative cultural evolution.
    1. Developmental Biology

    Correction: Embryo-derive TNF promotes decidualization via fibroblast activation

    Si-Ting Chen, Wen-Wen Shi ... Zeng-Ming Yang
    1. Medicine

    Hyperactivated glycolysis drives spatially patterned Kupffer cell depletion in MASLD

    Jia He, Ran Li ... Zhao Shan
    Glycolytic activation directly drives Kupffer cell loss in early metabolic dysfunction-associated steatotic liver disease, highlighting a targetable metabolic vulnerability.
    1. Neuroscience

    Multi-talker speech comprehension at different temporal scales in listeners with normal and impaired hearing

    Jixing Li, Qixuan Wang ... Zhiwu Huang
    Hearing impairment selectively disrupts neural tracking of speech at both short and long temporal scales during multi-speaker listening, while preserving intermediate linguistic processing.
    1. Cancer Biology

    Molecular architecture of the tumor microenvironment caused by BRCA1 and BRCA2 somatic mutations in human lung adenocarcinoma

    Gaoming Liao, Xinbin Yang ... Gang Xu
    BRCA1/2 mutations rewire the lung adenocarcinoma microenvironment through distinct immune programs, with BRCA1-linked type I interferon signaling and CD8+ T activation contrasting BRCA2-linked MHC-II antigen presentation and CD4+ T differentiation.
    1. Epidemiology and Global Health

    Repurposed small molecule toxin inhibitors neutralise a diversity of venoms from the Neotropical viperid snake genus Bothrops

    Rachel H Clare, Adam Westhorpe ... Nicholas R Casewell
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Epidemiology and Global Health

    Estimating probabilities of malaria importation in southern Mozambique through P. falciparum genomics and mobility patterns

    Arnau Pujol, Arlindo Chidimatembue ... Alfredo Mayor
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
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