Sci-L3-Strand-seq uncovers sister chromatid exchange as a frequent hidden outcome of Cas9-induced breaks, revealing genome-editing consequences that are invisible to conventional sequencing, and can be associated with structural variations.
Co-folding methods accurately place and rank ligands within an optimization series, yet fail to separate true binders from docking false positives, suggesting complementary roles in drug discovery.
Low-frequency depression, an understudied form of synaptic plasticity, is proposed to reflect a reorganization of synaptic vesicles inside the readily releasable pool.
