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Functional connectivity in rodent and human neuronal cultures is best explained by homophilic wiring rules, in which neurons preferentially form connections depending on spatial proximity and shared connectivity patterns, suggesting a unifying principle across scales.

Deep3DSIM enables super-resolution imaging >130 µm into complex tissues of fixed and live specimens in an upright configuration, allowing sample manipulation, as well as rapid refocusing without the need to move the specimen or objective lens.

A survey of reasoning behaviour in medical large language models uncovers emerging trends, highlights open challenges, and introduces theoretical frameworks that enhance reasoning behaviour transparency, ultimately fostering greater trust among clinicians, developers, and patients in their deployment.

In healthy volunteers, negative expectations exert stronger and longer-lasting effects on pain than positive expectations, consistent with a better-safe-than-sorry account of placebo and nocebo effects.

An RNAi based genetic screen and subsequent analyses reveal how dyneins and small GTPases coordinate autophagosome positioning at the ncMTOC in fat cells, advancing understanding of autophagic vesicle transport.

Learning new navigation or memory skills engages flexible brain network dynamics without altering gray matter, white matter, or hippocampal structure.

While the genes involved in craniofacial development are highly conserved between the fat-tailed dunnart and mouse, their cis-regulatory elements show significant divergence and appear to reflect species-specific developmental processes.

Blood flow enhances neuronal migration in the adult brain via ghrelin signaling.