Directly manipulating cellular energy levels suppresses catabolic pathways and enhances mitochondrial maintenance, establishing bioenergetic homeostasis as a fundamental driver of cellular longevity.
Olivia G Waltner, April A Apfelbaum ... Scott N Furlan
In Ewing sarcoma, a mesenchymal gene program normally repressed by the oncogenic fusion is reactivated by TGF-β signaling, and is associated with more aggressive disease.
Chiara Asselborn, Agata N Makar ... Alex von Kriegsheim
Simultaneous loss of GSTP1 and PHD2 activity is synthetically lethal in APC-mutant colorectal cells, driving cell-cycle arrest, metabolic collapse, and apoptosis.
Benjamin Brachi, Daniele Filiault ... Magnus Nordborg
A combination of common-garden and selection experiments identifies strong and often antagonistic selection pressures acting on different life stages, and that vary in space and time.
