Browse the latest research

18,303 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Homophilic wiring principles underpin neuronal network topology in vitro

    Danyal Akarca, Alexander WE Dunn ... Manuel Schröter
    Functional connectivity in rodent and human neuronal cultures is best explained by homophilic wiring rules, in which neurons preferentially form connections depending on spatial proximity and shared connectivity patterns, suggesting a unifying principle across scales.
    1. Neuroscience

    A stress-activated neuronal ensemble in the supramammillary nucleus encodes anxiety but not memory

    Jinming Zhang, Kexin Yu ... Jing Han
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Neuroscience

    Functional characterisation of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome

    Xiao Cong, Huachen Liu ... Muyan Chen
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Cell Biology

    Deep3DSIM: Super-resolution imaging of thick tissue using 3D structured illumination with adaptive optics

    Jingyu Wang, Danail Stoychev ... Ilan Davis
    Deep3DSIM enables super-resolution imaging >130 µm into complex tissues of fixed and live specimens in an upright configuration, allowing sample manipulation, as well as rapid refocusing without the need to move the specimen or objective lens.
    1. Computational and Systems Biology
    2. Medicine

    Critique of impure reason: Unveiling the reasoning behaviour of medical large language models

    Shamus Zi Yang Sim, Tyrone Chen
    A survey of reasoning behaviour in medical large language models uncovers emerging trends, highlights open challenges, and introduces theoretical frameworks that enhance reasoning behaviour transparency, ultimately fostering greater trust among clinicians, developers, and patients in their deployment.
    1. Neuroscience

    Nocebo effects are stronger and more persistent than placebo effects in healthy individuals

    Angelika Kunkel, Katharina Schmidt ... Ulrike Bingel
    In healthy volunteers, negative expectations exert stronger and longer-lasting effects on pain than positive expectations, consistent with a better-safe-than-sorry account of placebo and nocebo effects.
    1. Cell Biology

    The Rab7-Epg5 and Rab39-ema modules cooperatively position autophagosomes for efficient lysosomal fusions

    Attila Boda, Villő Balázs ... Péter Lőrincz
    An RNAi based genetic screen and subsequent analyses reveal how dyneins and small GTPases coordinate autophagosome positioning at the ncMTOC in fat cells, advancing understanding of autophagic vesicle transport.
    1. Neuroscience

    Newly trained navigation and verbal memory skills in humans elicit changes in task-related networks but not brain structure

    Li Zheng, Zachary Boogaart ... Steven M Weisberg
    Learning new navigation or memory skills engages flexible brain network dynamics without altering gray matter, white matter, or hippocampal structure.
    1. Developmental Biology
    2. Genetics and Genomics

    Gene regulatory dynamics during craniofacial development in a carnivorous marsupial

    Laura E Cook, Charles Y Feigin ... Irene Gallego Romero
    While the genes involved in craniofacial development are highly conserved between the fat-tailed dunnart and mouse, their cis-regulatory elements show significant divergence and appear to reflect species-specific developmental processes.
    1. Neuroscience

    Neuronal migration depends on blood flow in the adult mammalian brain

    Takashi Ogino, Akari Saito ... Kazunobu Sawamoto
    Blood flow enhances neuronal migration in the adult brain via ghrelin signaling.

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