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19,309 results found
    1. Cancer Biology

    JAK-STAT pathway heterogeneity governs immunotherapy response in breast cancer

    Jianbo Zhou, Heng Zhang ... Fu Peng
    Multi-omics investigation identifies cell-type JAK-STAT heterogeneity as a predictive biomarker for PD-1 blockade in breast cancer.
    1. Physics of Living Systems

    Anatomy and mechanics of tsetse fly blood feeding

    Stephan Löwe, Laura Hauf ... Markus Engstler
    A saw-like proboscis, forceful pulling movements, and precise targeting of softer skin sites allow tsetse flies to draw blood from remarkably diverse vertebrate hosts.
    1. Neuroscience
    2. Computational and Systems Biology

    A theory-guided model maps four recurrent modes of fear-goal arbitration across learning and relapse in rats

    Bin Yin, Jiaojiao Rao, XT (XiaoTian) Wang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Spatiotemporal Dissociation of Human Amygdala Response to Negative Affect

    Ke Bo, Martin A Lindquist ... Tor D Wager
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Phosphorylation and pocket-binding ligands rewire the coupled networks in multidomain protein condensate

    Yu Cao, Jinyu Chen, Xiakun Chu
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Developmental Biology

    Wnt/beta-catenin signaling regulates Vascular Endothelial Growth Factor (VEGF) receptors in central nervous system endothelial cells

    Yanshu Wang, Ningyu Zhu ... Jeremy Nathans
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Cell Biology

    Whole human organ clearing and multimodal mapping

    Héloïse Policet-Bétend, Tomàs Jordà-Siquier ... Christophe M Lamy
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Computational and Systems Biology

    Penumbria: Advanced 3D cell segmentation for biomedical imaging

    Laurids Stockert, Joseph Donovan, Herwig Baier
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Microbiology and Infectious Disease

    SIRT2 protects against Japanese encephalitis virus infection in mice

    Perumal Arumugam Desingu, Lavanya Dindi ... Nagalingam R Sundaresan
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Chromosomes and Gene Expression

    Genome-wide mapping of Cas9-induced sister chromatid exchange across single and over 200 genomic sites in human cells

    Peter Chovanec, Shiyang He, Yi Yin
    Sci-L3-Strand-seq uncovers sister chromatid exchange as a frequent hidden outcome of Cas9-induced breaks, revealing genome-editing consequences that are invisible to conventional sequencing, and can be associated with structural variations.
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