The glycolipid MPIase acts as a receptor of twin-arginine translocation (TAT) signals, inserts them into membranes, and potentially modulates the TatABC structure to facilitate TAT translocation.
Yi Lueningschroer-Wang, Emilia Derksen ... Christian Wegener
Wall-following and total walking activity in a behavioural assay can serve as indicators of emotional valence and arousal and provide evidence for the presence of emotion primitives in fruit flies.
Morgane Vandendoren, Jason G Landen ... Adam Nelson
Oxytocin neurons couple physiological warming to behavioral arousal, revealing a homeostatic mechanism that coordinates transitions between low- and high-energy states.
Simulation-based inference predicts putative circuit mechanisms of hyperexcitability in a phenomenological microcircuit simulator with more than 30 free intrinsic and synaptic parameters.
The interaction of important signaling pathway members identified through in silico and in vitro approaches provides a model that suggests local receptor multimerization through bridging functions of various ligands.
