Magazine

Highlighting the latest research and giving a voice to scientists
Illustration by Davide Bonazzi

Highlights

    1. Immunology and Inflammation

    Antibiotic-resistant bacteria

    Troy Burtchett, Neal Hammer
    1. Neuroscience

    How working memory works

    Jacob A Miller
    1. Cell Biology
    2. Developmental Biology

    Not all dimers are equal

    Jeet H Patel, Mary C Mullins
    1. Cancer Biology
    2. Cell Biology

    Cell crowding and cancer

    Rui Hua, Jean X Jiang
    1. Neuroscience

    Neuropeptides and pain

    Weihua Cai, Arkady Khoutorsky

Highlights controls:

Latest articles

    1. Chromosomes and Gene Expression

    Gene Regulation: Linking O-GlcNAc and intron retention

    John A Hanover
    An elegant screening strategy unveils a molecular actor that connects widespread changes in mRNA processing with a nutrient-sensing protein modification.
    Version of Record
    Insight
    1. Cell Biology
    2. Developmental Biology

    Cell Signaling: Not all dimers are equal

    Jeet H Patel, Mary C Mullins
    Disease-causing mutations in the signaling protein BMP4 impair its secretion, but only when it is made as a homodimer.
    Version of Record
    Insight
    1. Immunology and Inflammation

    Bacterial Clearance: With a little help from T cells

    Troy Burtchett, Neal Hammer
    Specific host factors, such as immune cell activity, sex hormones and microbiota composition, influence the ability of Staphylococcus aureus bacteria to colonize the gut of mice.
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    Insight
  1. members of the coordinating team for the Brazilian Reproducibility Initiative

    Reproducibility: How replicable is biomedical science in Brazil?

    The results of a project to estimate the reproducibility of research in Brazil have just been published.
  2. Image of the female leafhopper Macrosteles quadrilineatus

    Episode 98: April 2025

    In this episode, we hear about parasites as molecular matchmakers, drug combinations and cancer treatment, chemical defences in poison frogs, the impact of education on brain structure, and what movies can reveal about the organisation of the infant visual system.
    1. Neuroscience

    Cognition: When working memory works for our goals

    Jacob A Miller
    When navigating environments with changing rules, human brain circuits flexibly adapt how and where we retain information to help us achieve our immediate goals.
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    Insight
    1. Cancer Biology
    2. Cell Biology

    Breast Cancer: How cell crowding causes cancer cells to spread

    Rui Hua, Jean X Jiang
    Cell crowding causes high-grade breast cancer cells to become more invasive by activating a molecular switch that causes the cells to shrink and spread.
    Version of Record
    Insight
    1. Neuroscience

    Pain: Revisiting the role of Substance P and CGRPα

    Weihua Cai, Arkady Khoutorsky
    Mice lacking two neuropeptides thought to be essential for processing pain show no change in how they respond to a wide range of harmful stimuli.
    Version of Record
    Insight
    1. Genetics and Genomics
    2. Neuroscience

    Neuronal Signaling: Cell-specific tools for understanding behavior

    Brandon L Holder, Stephane Dissel
    Novel tools that allow neuron-specific investigations of the structure controlling sleep regulation in fruit flies reveal the extent of neuronal heterogeneity.
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    Insight
    1. Cell Biology
    2. Medicine

    Pulmonary Hypertension: When cell teamwork turns toxic

    Wadih EI Khoury, Stephen Y Chan
    In pulmonary hypertension, a combination of metabolic and mechanical dysfunction leads to irreversible vascular damage.
    Version of Record
    Insight