Magazine

Highlighting the latest research and giving a voice to scientists
Illustration by Davide Bonazzi

Highlights

    1. Neuroscience

    Rethinking how memories are retrieved

    Rocco Pizzarelli, Marilena Griguoli
    1. Neuroscience

    Psychedelic drugs and neuroplasticity

    Jessica L Maltman, Javier González-Maeso

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Latest articles

    1. Neuroscience

    Neuroanatomy: Hidden folds reveal brain organization

    Jürgen Germann
    Previously underappreciated folds in the cerebral cortex provide insight into how its structure varies across individuals.
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    Insight
    1. Neuroscience

    Orbitofrontal Cortex: Cocaine disrupts hidden states in the brain

    Margo Le, Ronald Keiflin
    Cocaine use disrupts the encoding of abstract states in the orbitofrontal cortex.
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    Insight
    1. Structural Biology and Molecular Biophysics

    Glycobiology: How enzymes make the right choice during biosynthesis

    Ana S Ramírez, Camilo Perez
    The biosynthesis of an important biopolymer called hyaluronan requires an enzyme that discriminates between two different substrates.
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    Insight
    1. Neuroscience

    Memory Encoding and Retrieval: Rethinking how memories are retrieved

    Rocco Pizzarelli, Marilena Griguoli
    Patterns of neural activity called theta oscillations have a role in memory encoding but – contrary to current thinking – do not appear to have a role in memory retrieval.
    Version of Record
    Insight
    1. Structural Biology and Molecular Biophysics

    Membrane Biology: Two binding sites are better than one

    Mackenzie K Scott, John E Burke
    The reasons why two multiprotein complexes – VPS34 complex I and VPS34 complex II – are activated by different Rab proteins are becoming clearer.
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    1. Neuroscience

    Psychedelic Drugs: Reshaping human neurons

    Jessica L Maltman, Javier González-Maeso
    Human neurons derived from stem cells show increased structural complexity and stronger synaptic connections after exposure to psilocin, the active metabolite of the psychedelic psilocybin.
    Version of Record
    Insight
    1. Structural Biology and Molecular Biophysics

    Membrane Proteins: A missing link for efflux pumps

    Hilal Wehbi, Isabelle Broutin
    A lipoprotein called YbjP could be the answer to a puzzle about efflux pumps in gram-negative bacteria.
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    Insight
    1. Microbiology and Infectious Disease

    Gut Microbiome: Bacteria weigh up costs and benefits of mobile weapons

    Zhao Wang, Yang Fu
    Gaining the ability to kill rival microbes is not always an advantage for bacteria in complex gut microbiomes.
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    Insight
    1. Neuroscience

    Neuropathic Pain: Closing in on the causes of chronic neuropathic pain

    Geoffroy Laumet
    Chronic neuropathic pain in mice is maintained by the translation of messenger RNA in inhibitory neurons, so drugs that modulate translational pathways may be able to treat this condition.
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  1. Point of View: An easy way to improve lab meetings

    Cara Glynn, Tiago Monteiro
    Sharing positive and negative experiences at lab meetings can make a career in science a little less hard, a little more pleasant, and a little more human.