Results from the Reproducibility Project: Cancer Biology provide a picture of the rate of false positives in cancer preclinical research, but it is still not clear if research in this field is less reproducible than it should be.
As the final outputs of the Reproducibility Project: Cancer Biology are published, it is clear that preclinical research in cancer biology is not as reproducible as it should be.
A project to repeat experiments from high-impact papers in cancer biology encountered a series of challenges, many of which were caused by a lack of detail in the original papers.
Harnessing single-molecule FRET illuminates the structural changes necessary for a protein to fine-tune the influx of calcium when reserves inside a cell run low.
The visual maps measured non-invasively in the brain of human and non-human primates reliably reflect the underlying neuronal responses recorded with invasive electrodes.
Using multiple analysts to independently analyze the same dataset has the potential to explore and strengthen the robustness of results and conclusions in basic and applied research.
Concealing the identity of the principal investigator only partially closes the success gap between white and African American or Black researchers in NIH grant applications.
