Magazine

Latest articles

1. 1. Cancer Biology

   Breast Cancer: Slowing the growth of drug-resistant tumors

   Yingyi Zhang, Qianying Lu

   Using drugs that inhibit enzymes called CDK4/6 and CDK2 extends the G1 phase of the cell cycle and helps to slow the growth of drug-resistant breast cancer.
2. 1. Neuroscience

   Experience-Dependent Plasticity: The little brain supervises learning in the big brain

   Martha Garcia, Mark Wagner

   Experiments on mice reveal how the cerebellum modulates plasticity in the somatosensory cortex.
3. 1. Microbiology and Infectious Disease

   Tuberculosis: A surprising new hiding place for a dangerous pathogen

   Sheetal Gandotra, Yogendra Singh

   The bacterium that causes TB can hide in liver cells called hepatocytes, and reprogram their metabolism for its own benefit.
4. 

   Episode 101: December 2025

   In this episode, we hear about the development of the visual system, nocebo effects versus placebos, cross-species insemination, telomere length, and efforts to recreate Darwin’s “warm little pond”.
5. 1. Neuroscience

   Neuronal Activity: Keeping track of moving targets

   Renata Batista-Brito, Geoffrey Terral

   A new method for tracking the activity of individual neurons day after day in the growing brain has revealed a key developmental transition in neuronal activity.

6. Research Culture: The SAFE Labs Handbook as a tool for improving lab culture

   Erika Donà, James M Gahan ... Philip Coen

   A survey of more than 200 researchers shows strong support for a new community-driven lab handbook that can be implemented by individual group leaders to reduce conflict and create more positive and equitable work environments.
7. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Metabolism: How one nutrient controls cell size

   Angela Montero, Lydia WS Finley

   The metabolic fate of a nutrient called pyruvate determines how big cells become.
8. 1. Genetics and Genomics

   Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance

   Lesley T MacNeil

   Evidence that learned avoidance of a pathogenic bacterium can be transmitted to future generations in C. elegans is growing.
9. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease
   3. Medicine

   

   Focus Issue: Trained Immunity

   Edited by Satyajit Rath et al.

   Our latest Focus Issue looks at what we’ve learnt over the past decade and what’s next for the field of trained immunity.
10. 1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Focus Issue: Evolving our understanding of trained immunity

    Eva Kaufmann, Yahya Sohrabi ... Jos WM van der Meer

    The articles in this focus issue discuss progress towards a more complete understanding of memory in the innate immune system, and efforts to exploit "trained immunity" for the development of new vaccines and therapeutics.