Magazine

Latest articles

1. 1. Genetics and Genomics

   Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance

   Lesley T MacNeil

   Evidence that learned avoidance of a pathogenic bacterium can be transmitted to future generations in C. elegans is growing.
2. 1. Medicine
   2. Immunology and Inflammation
   3. Microbiology and Infectious Disease

   

   Focus Issue: Trained Immunity

   Edited by Satyajit Rath et al.

   Our latest Focus Issue looks at what we’ve learnt over the past decade and what’s next for the field of trained immunity.
3. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Focus Issue: Evolving our understanding of trained immunity

   Eva Kaufmann, Yahya Sohrabi ... Jos WM van der Meer

   The articles in this focus issue discuss progress towards a more complete understanding of memory in the innate immune system, and efforts to exploit "trained immunity" for the development of new vaccines and therapeutics.
4. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Bacteriology: How Shigella tackles host defences

   Yizhou Huang, Teresa LM Thurston

   The pathogenic bacteria Shigella avoids detection inside hosts cells by degrading RNF213, the protein responsible for sensing the presence of intracellular pathogens.
5. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Chromosomes: Exploring a crossroads in the aging process

   Kiyan Shabestary, Daniel E Gottschling

   Experiments on yeast show that the nuclear pore complex has a central role in the loss of chromosomes associated with aging.
6. 1. Neuroscience

   Neuronal Migration: How hunger guides new brain cells to their destination

   Fang-Shin Nian, Laurent Nguyen

   Blood flow and a hormone called ghrelin help new neurons travel to where they are meant to be in the brain of adult mice.
7. 1. Neuroscience

   Primate Research: Probing the staying power of chemogenetics

   Maria Puchik, Igor Kagan

   A study that monitored the expression and function of designer receptors called DREADDs in macaque monkeys for a period of three years demonstrates that they are effective in long-term studies of nonhuman primates.
8. 1. Genetics and Genomics
   2. Neuroscience

   Aging: Unlocking the longevity code with stress

   Loren Cocciolone, Valeria Uvarova, Patricija van Oosten-Hawle

   Manipulating the neuronal pathway responsible for the hypoxic stress response in the worm C. elegans leads to an increase in lifespan.
9. 1. Developmental Biology

   Blastomeres: Tracing cell fates in embryos

   Ying Zhang, Qi Chen

   Differences in the activity of an enzyme called CARM1 influence the timing of blastomere polarization and whether they become part of the embryo or the placenta.
10. 1. Cancer Biology

    Transcription Factor-Dependent Cancers: Targeting chromatin remodeling complexes to treat uveal melanoma

    Jonas A Nilsson

    A novel compound that inhibits the BAF chromatin remodeling complex causes regression in an animal model of the incurable cancer uveal melanoma.