Symposium: Aging, Geroscience and Longevity Special Issue

Join eLife authors at our online symposium on December 14 as they showcase their research from the Aging, Geroscience and Longevity Special Issue.
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Would you like to hear the latest findings in the field of aging, geroscience and longevity? eLife Senior Editors Jess Tyler and Matt Kaeberlein invite you to join them for a half-day online symposium, where authors of our upcoming Special Issue on this topic will present the key findings from their research. Biological aging is the greatest risk factor for nearly every major cause of death and disability in developed countries, and new insights into the aging process may fundamentally change the way we approach human health. From basic research on the cellular and molecular hallmarks of aging to the next generation of “aging clocks” to potential clinical interventions, the symposium presents the opportunity to hear the very latest from your colleagues in this field.

Accepted authors will present their research through live and pre-recorded presentations. At the end of each live session, participants will have the opportunity to ask questions.

The symposium is free to attend and will be taking place December 14, 2pm UTC | 10am EDT | 3pm CET.

  1. Register here

Confirmed speakers and bios (more to be added):

Click here to find the times in your time zone.

2.30pm UTC

Sara Hägg, PhD, Associate Professor
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden
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Measurements of biological age in a Swedish longitudinal study of aging
Biological age measurements are biomarkers associated with the aging process beyond chronological age. Many such measurements exist, from cellular markers, such as telomere length and the epigenetic clock, to more comprehensive markers covering a whole organ or body capacity, such as physical function and frailty. In our longitudinal cohort – the Swedish Adoption/Twin Study of Aging (SATSA) – we followed individuals between 1984-2014 and performed up to nine in-person testings with cognitive and functional assessments, life-style questionnaires and blood draw. Using these data, we developed nine measurements of biological age: telomere length, four types of the epigenetic clock, physiological age, cognitive function, a functional aging index and frailty, and created longitudinal trajectories to track individual changes across old adulthood. Furthermore, we assessed correlations between the biological age measurements, and associations with mortality, both in univariate and multivariate models.

Read the full Research Article here.

4.20pm UTC

Dudley Lamming, PhD, Associate Professor
University of Wisconsin-Madison

Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging
Inhibition of mTOR (mechanistic Target Of Rapamycin) signaling by rapamycin promotes healthspan and longevity more strongly in females than males, perhaps because inhibition of hepatic mTORC2 (mTOR Complex 2) specifically reduces the lifespan of males. Here, we demonstrate using gonadectomy that the sex-specific impact of reduced hepatic mTORC2 is not reversed by depletion of sex hormones. Intriguingly, we find that ovariectomy uncouples lifespan from metabolic health, with ovariectomized females having improved survival despite paradoxically having increased adiposity and decreased control of blood glucose levels. Further, ovariectomy unexpectedly promotes midlife survival of female mice lacking hepatic mTORC2, significantly increasing the survival of those mice that do not develop cancer. In addition to identifying a sex hormone-dependent role for hepatic mTORC2 in female longevity, our results demonstrate that metabolic health is not inextricably linked to lifespan in mammals, and highlight the importance of evaluating healthspan in mammalian longevity studies.

Read the full Research Article here.

4.40pm UTC

Amanda Kowalczyk, PhD Candidate
Carnegie Mellon University – University of Pittsburgh Joint PhD Program in Computational Biology, United States

Pan-mammalian analysis of molecular constraints underlying extended lifespan
Much research to identify the genetic basis of long life has focused on seeking unique genetic changes in exceptionally long-lived species like the naked mole-rat, bats, and the bowhead whale. Unfortunately, such species-specific adaptations do not often generalize to other mammals, including humans. To find pan-mammalian lifespan-regulating genes that may play a role in human longevity, we use a comparative genomics approach to identify convergent genetic changes associated with longevity across all mammals. Our novel computational method identifies associations between evolutionary rates and continuous phenotypes to find a slew of genes that implicate broad-scale functions such as cell cycle control, immune function, and DNA repair in lifespan extension. Considered together, these functions imply that effective cancer control is a key adaptation underlying the evolution of extreme longevity.

Read the full Research Article here.

5.10pm UTC

Michael Polymenis, PhD, Professor
Department of Biochemistry and Biophysics, Texas A&M University, United States

​​​​​​Coupling one carbon metabolism with longevity
We queried actively dividing ribosomal protein mutants to answer why some of them have altered cell cycle kinetics and longer replicative lifespan. Our data link transcriptional, translational, and metabolic changes to phenotypes associated with the loss of specific ribosomal proteins. We uncovered translational control of transcripts encoding enzymes of methionine and serine metabolism, which are part of one-carbon (1C) pathways. Cells lacking Rpl22Ap, which are long-lived, have lower levels of metabolites associated with 1C metabolism. Loss of 1C enzymes increased the longevity of wild type cells. 1C pathways exist in all organisms and targeting the relevant enzymes could represent longevity interventions.

Read the full Research Article here.

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