Johns Hopkins scientists have discovered a new mode of action for enzymes immersed in cellular membranes. Their experiments suggest that instead of recognizing and clipping proteins based on sequences of amino acids, these proteases’ location within membranes gives them the unique ability to recognize and cut proteins with unstable structures.
In a report published online Nov. 13 in the new journaleLife, the Johns Hopkins scientists say their study results are the first to shed light on how these enzymes make use of their native environment to function.
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