Editors for Biochemistry and Chemical Biology
Senior editors
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Anna Akhmanova
Utrecht University, Netherlands
Anna Akhmanova is a Professor of Cell Biology at the Department of Biology, Faculty of Science, Utrecht University, the Netherlands. She studied biochemistry and molecular biology at the Moscow State University and obtained her PhD at the University of Nijmegen, the Netherlands. Akhmanova studies cytoskeletal organization and trafficking processes, which contribute to cell polarization, differentiation, vertebrate development and human disease. The main focus of the work in her group is the microtubule cytoskeleton. Research in the group relies on combining high-resolution live cell imaging and quantitative analysis of cytoskeletal dynamics with in vitro reconstitution experiments. Her work has resulted in identification and characterization of a broad variety of factors which control microtubule organization and dynamics and motor attachment to membrane organelles. Anna Akhmanova is an elected member of the European Molecular Biology Organization and the Royal Netherlands Academy of Arts and Sciences.
- Expertise
- Cell Biology
- Biochemistry and Chemical Biology
- Research focus
- cytoskeleton
- cytoskeletal dynamics
- microtubules
- microtubule-binding proteins
- motor proteins
- membrane transport
- cell migration
- Experimental organism
- human cells
- mouse
- Competing interests statement
- Anna Akhmanova receives funding from the European Research Council, Human Frontier Science Program, and the Netherlands Organization for Scientific Research. She is a member of the Scientific Advisory Board of the Netherlands Institute for Neuroscience. She served on the editorial boards of BMC Cell Biology and Journal of Biological Chemistry. She is a currently on the editorial boards of PLOS Biology, Journal of Cell Science, Traffic, and BioArchitecture.
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Richard Aldrich
The University of Texas at Austin, United States
Rick Aldrich is the Karl Folkers Chair II in Interdisciplinary Biomedical Research and Professor of Neuroscience at The University of Texas at Austin. He joined the faculty in 2006 and served as chair until 2011. Previously he was on the faculty of Neurobiology (1985-1990) and of Molecular and Cellular Physiology (1990-2006) at Stanford University where he served as department chair from 2001–2004. He was an investigator with the Howard Hughes Medical Institute from 1990 to 2006. His work is on molecular mechanisms of ion channels and calcium signaling proteins, with an emphasis on understanding gated conformational changes and allosteric mechanisms. Work in the laboratory is multidisciplinary including electrophysiology, biochemistry, spectroscopy, informatics and computation. He is a member of the National Academy of Science and the American Academy of Arts and Sciences, and is a Fellow of the American Association for the Advancement of Science and of the Biophysical Society. He is past president of the Biophysical Society and the Society of General Physiologists, and has received the Kenneth Cole Award for Membrane Physiology from the Biophysical Society and Alden Spencer Award for Neuroscience Research from Columbia University.
- Expertise
- Structural Biology and Molecular Biophysics
- Neuroscience
- Biochemistry and Chemical Biology
- Research focus
- ion channels
- calcium binding proteins
- membrane transport
- allostery and cooperativity
- cellular neurophysiology
- biochemical neuroscience
- Competing interests statement
- Richard Aldrich is employed by The University of Texas at Austin. He receives research funding from the National Institutes of Health. He is a member of the National Academy of Science and the American Academy of Arts and Sciences, and is a Fellow of the American Association for the Advancement of Science and of the Biophysical Society. He serves actively on the editorial boards of Proceedings of the National Academy of Sciences and The Journal of General Physiology.
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Philip Cole
Harvard Medical School, United States
Phil Cole is Professor of Medicine and Biological Chemistry and Molecular Pharmacology at Harvard Medical School and is a Senior Investigator in the Division of Genetics at Brigham and Women's Hospital. He graduated from Yale University with a B.S. in Chemistry and then spent a year as a Churchill Scholar at the University of Cambridge prior to obtaining M.D. and Ph.D. degrees from Johns Hopkins School of Medicine where he pursued research in bioorganic chemistry. Cole then entered post-doctoral and clinical training at Harvard Medical School and Brigham and Women's Hospital. He subsequently held faculty positions at Rockefeller University and then Johns Hopkins where he was Chair of Pharmacology prior to returning to Harvard in 2017. His research interests are related to the chemical biology of cell signaling and epigenetics. His group has developed and applied methods for protein semisynthesis and small molecule probes for kinases, acyltransferases, deacetylases, and demethylases. His honors include election to the ASCI, fellow of the AAAS, and receipt of an NIH MERIT award.
- Expertise
- Biochemistry and Chemical Biology
- Structural Biology and Molecular Biophysics
- Research focus
- protein modification
- enzyme mechanisms
- cell signalling
- epigenetics
- Competing interests statement
- Philip Cole is on the Scientific Advisory Boards of Memorial Sloan-Kettering Cancer Center, the Maryland Institute of Bioscience and Biotechnology Research, and the Searle Scholars Program. He is a cofounder of Acylin Therapeutics Inc and a science advisor for the Abbvie, Epizyme, and Forma companies and has been a consultant for MPM Capital. Cole has received research funding from the NIH, the FAMRI foundation, and the V Foundation. He is a member of the editorial boards of the following journals: J Biol Chem, Biomed Central Biology, ChemBioChem, and Bioorganic Chemistry.
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Volker Dötsch
Goethe University, Germany
Volker Dötsch is Professor of Biophysical Chemistry at Goethe University and a member of the Magnetic Resonance Center Frankfurt. He studied chemistry at the University of Göttingen and obtained a PhD from the ETH in Zürich. As a postdoctoral fellow he used NMR to determine the structure of protein-DNA complexes at the Harvard Medical School. In 1998 he moved as assistant professor to the University of California San Francisco (UCSF). In 2003 he was appointed professor at the Institute of Biophysical Chemistry of Goethe University in Frankfurt. His research interests focus on the structural and functional characterization of members of the p53 protein family, in particular p63 and its involvement in genetic quality control in germ cells. In addition, his laboratory uses a combination of NMR spectroscopy and cell-free protein expression to investigate the structure and function of membrane proteins and studies molecular interactions regulating autophagy. His lab uses a wide variety of biophysical methods including NMR spectroscopy and combines these studies with investigations in cell culture experiments and mouse models. Volker Dötsch is an elected EMBO member.
- Expertise
- Structural Biology and Molecular Biophysics
- Biochemistry and Chemical Biology
- Research focus
- p53 protein family
- cell-free expression and membrane protein structure and function
- autophagy
- Competing interests statement
- Volker Dötsch has received funding from the Deutsche Forschungsgemeinschaft, the National Institutes of Health and the Deutsche Krebshilfe. He is on the Scientific Advisory Board of the Frankfurt Institute of Advanced Studies and a member of the editorial boards of Journal of Biological Chemistry and Cell Death & Disease.
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José Faraldo-Gómez
Senior Editor
José Faraldo-Gómez studied Physics at the Universidad Autónoma in Madrid, Spain, and went on to pursue a PhD degree in the Laboratory of Molecular Biophysics at the University of Oxford, graduating in 2002. He then moved to the United States, and acquired postdoctoral training first at the Weill Medical College of Cornell University in New York City, and subsequently at the University of Chicago. His pre- and post-doctoral work was focused on membrane proteins and in later years also on signaling enzymes, studied through computer simulations and other theoretical methods. In late 2007, Dr Faraldo-Gómez established the Theoretical Molecular Biophysics Laboratory at the Max Planck Institute of Biophysics in Frankfurt, Germany. In 2013, Dr Faraldo-Gómez relocated his laboratory to the National Institutes of Health, in Bethesda, MD, USA, where he joined the National Heart, Lung and Blood Institute as a Tenure-Track Investigator. He became a tenured Senior Investigator in 2016. Dr Faraldo-Gómez served as a handling editor at the Biophysical Journal from 2011 to 2017, and as an Associate Editor in the Journal of General Physiology from 2016 to 2019. At eLife, he first served as a Reviewing Editor, from 2017 to 2019, and is now a Senior Editor.
- Expertise
- Biochemistry and Chemical Biology
- Structural Biology and Molecular Biophysics
- Research focus
- computational biophysics
- molecular computation
- membrane proteins
- Competing interests statement
- José Faraldo-Gómez has no competing interests to disclose. Dr Faraldo-Gómez is a Senior Investigator at the National Heart, Lung and Blood Institute of the US National Institutes of Health.
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Vivek Malhotra
The Barcelona Institute of Science and Technology, Spain
Vivek Malhotra was a professor in the biology division at UC San Diego from 2007 and is now the ICREA Professor and Chair of the Cell and Developmental Biology at Center for Genomic Regulation (CRG) in Barcelona. His research focuses on a central station of the secretory pathway, the Golgi complex. Specifically, his work has resulted in the identification of the machinery required for the sorting and packaging of secretory cargoes. His recent work has uncovered a novel secretory routing that bypasses the conventional pathway of protein secretion. He has identified new genes required for the export of bulky collagens and the regulated secretion of mucins. He received his BSc from Stirling University and was a Pirie–Reid scholar at Oxford, a Damon Runyon Walter Winchell and an American Cancer Society postdoctoral fellow at Stanford, and Basil O’Conner scholar, established Investigator of the American Heart Association, and Senior Investigator of Sandler’s Foundation for Asthma at UC San Diego. He received the MERCK award from the American Society of Biochemistry and Molecular Biology, is a fellow of the American association of the arts and science, and is an elected EMBO member.
- Expertise
- Biochemistry and Chemical Biology
- Cell Biology
- Research focus
- Golgi membranes
- protein secretion
- collagen
- mucins
- unconventional protein secretion
- Competing interests statement
- Vivek Malhotra receives funding from ERC/European Research Council, Ministerio de Economía y Competitividad, AGAUR and the Plan Nacional (Spain) He is a Scientific Advisory Board member of TIGEM (Naples, Italy), CNR (Naples, Italy), CBMSO (Madrid, Spain) and Department of Biotechnology (India). He has served on the editorial board of Cell and was an associate editor of Molecular Biology of the Cell. He is currently on the editorial boards of Journal of Cell Biology and Current Opinion in Cell Biology.
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Michael Marletta
University of California, Berkeley, United States
Michael Marletta holds the CH and Annie Li Chair in the Molecular Biology of Disease and is Professor of Chemistry and of Molecular and Cell Biology at the University of California, Berkeley. Previous to his appointment at UC Berkeley, he was a former President and CEO of The Scripps Research Institute. He has also been on the faculty of the University of Michigan, where he was an HHMI Investigator, and MIT. Marletta obtained an A.B. in chemistry and biology from the State University of New York at Fredonia, a PhD from UCSF under George Kenyon and, after a postdoctoral appointment at MIT under Chris Walsh, began his independent career at MIT. His work has spanned protein chemistry and enzymology. He has made many contributions to our understanding of nitric oxide signaling and more generally in molecular mechanisms of gas sensing in eukaryotes and prokaryotes. More recent studies have involved novel enzymes involved with cellulose degradation. Marletta is a member of the National Academy of Sciences, the National Academy of Medicine, the American Academy of Arts and Sciences and the American Philosophical Society.
- Expertise
- Biochemistry and Chemical Biology
- Research focus
- chemical biology
- nitric oxide signaling
- gas sensing
- structural basis of enzyme activity
- enzymology
- protein structure
- protein function
- metals in biology
- cell signaling
- Experimental organism
- E. coli
- human
- Competing interests statement
- Michael Marletta has received funding from the NIH, NSF, HHMI, and the Burroughs-Wellcome Fund. He is a member of the Biomedical Sciences Advisory Board at Vanderbilt University. He is a member of the Foundation Board at SUNY Fredonia. He is a co-founder of Omniox, Inc. He is a member of the Intelligence Community Studies Board of the National Academies.
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Suzanne R Pfeffer
Stanford University School of Medicine, United States
Suzanne Pfeffer is the Emma Pfeiffer Merner Professor of Medical Sciences and Professor of Biochemistry at Stanford University School of Medicine. She is an expert in the field of membrane trafficking in the secretory and endocytic pathways, and her research currently focuses on the molecular basis of LRRK2-mediated, familial Parkinson's Disease and Niemann Pick Type C disease, with emphasis on Rab GTPase regulation and cholesterol export from lysosomes. She is a past President of the American Society for Cell Biology and the American Society of Biochemistry and Molecular Biology and a Fellow of the American Society for Cell Biology, the American Association for the Advancement of Science and the American Academy of Arts and Sciences.
- Expertise
- Cell Biology
- Biochemistry and Chemical Biology
- Neuroscience
- Research focus
- membrane trafficking
- endosomes
- lysosomes
- Golgi complex
- neurodegeneration
- Parkinson's disease
- endocytosis
- secretory pathway
- Rab GTPase
- primary cilia
- Experimental organism
- human
- mouse
- Competing interests statement
- Suzanne Pfeffer's research is currently funded by the National Institutes of Health, the Michael J. Fox Foundation and the Ara Parseghian Medical Research Foundation. She serves on the Scientific Advisory Board of the Ara Parseghian Medical Research Foundation, the Swiss National Science Foundation funded NCCR program in Chemical Biology at the EPFL and University of Geneva, and she is a chartered member of the NIH NCSD review panel. Suzanne Pfeffer also serves as Co-Section Head for Membranes and Sorting, Faculty of 1000.
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David Ron
Cambridge University, United Kingdom
David Ron is a Professor at Cambridge University. He directs a lab at the Cambridge Institute for Medical Research (CIMR) studying protein-folding homeostasis in the endoplasmic reticulum (ER). The lab uses biochemical, biophysical and cell-based tools to research both the molecular mechanisms that recognize the burden of unfolded proteins and thus initiate signalling in the ER unfolded protein response (UPR) and the downstream effector pathways by which cells adapt to unfolded protein stress in their ER. These effector mechanisms engage post-translational regulation of ER chaperone function, regulated translation of mRNA and transcriptional control of gene expression and thus interface with other cellular stress pathways.
To eLife, David Ron brings scientific expertise in the study of the unfolded protein response, chaperone function and stress-induced regulation of mRNA translation and editorial experience from having served as an eLife Reviewing Editor since 2012.
- Expertise
- Biochemistry and Chemical Biology
- Cell Biology
- Research focus
- chaperones
- unfolded protein response
- oxidative protein folding
- protein synthesis
- Experimental organism
- C. elegans
- E. coli
- human
- mouse
- S. cerevisiae
- Competing interests statement
- David Ron holds a Wellcome Trust Principal Research Fellowship and is on the editorial advisory boards of J. Cell Science, PLOS Biology and EMBO J.
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Dominique Soldati-Favre
University of Geneva, Switzerland
Dr Dominique Soldati-Favre studied biochemistry and earned her PhD degree in molecular biology from the University of Zürich (Switzerland) in 1990. She then conducted postdoctoral research in the Department of Microbiology and Immunology of the Stanford University School of Medicine. In 1995 she was appointed assistant professor at the Center for Molecular Biology at the University of Heidelberg (Germany). In 2001 she moved to Imperial College London (United Kingdom) and became Reader. Since 2004, she is professor at the Faculty of Medicine of the University of Geneva.
Her laboratory is studying obligate intracellular parasitism using Toxoplasma gondii and is also increasingly engaged in malaria research. The main line of research focuses on the cell biology underlying how these pernicious pathogens glide into mammalian cells. Her group is also aiming at defining the metabolic needs and capabilities of the parasites as well as how they subvert host cellular functions in particular to access nutrients.
- Expertise
- Microbiology and Infectious Disease
- Biochemistry and Chemical Biology
- Cell Biology
- Genetics and Genomics
- Research focus
- parasitology
- organelle biogenesis
- protein trafficking
- metabolism
- host pathogen interaction
- signalling
- Experimental organism
- T. gondii
- apicomplexans
- kinetoplastids
- Competing interests statement
- Dominique Soldati-Favre currently receives funding from the European Research Council and from the Swiss National Science Foundation. She is editor for Parasitology at Molecular Microbiology and she is on the editorial boards of PLOS Pathogens, Traffic and mBio.
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Kenton J Swartz
National Institute of Neurological Disorders and Stroke, NIH, United States
Kenton Swartz has been a Senior Investigator in the National Institute of Neurological Disorders and Stroke within the National Institutes of Health in Bethesda, Maryland since 2003. He obtained a BS in Chemistry and Biology from Eastern Mennonite College in 1986 and a PhD in Neurobiology from Harvard Medical School in 1993, where he worked with Bruce Bean studying the regulation of voltage-gated calcium channels by G-proteins and protein kinases. He obtained postdoctoral training with Roderick MacKinnon at Harvard Medical School, where he began isolating and studying toxins that interact with voltage-activated potassium channels. His laboratory uses biochemical, molecular biological, biophysical and structural techniques to understand how ion channel proteins sense critical biological stimuli, including membrane voltage, temperature, and both chemical and mechanical signals. He received an NIH Directors Award for Scientific Achievement in 2008, an NIH Office of the Director Honor Award on behalf of the Diversity Task Force in 2011 and the Kenneth S. Cole Award from the Biophysical Society in 2017. He has also served as the president of the Society of General Physiologists.
- Expertise
- Structural Biology and Molecular Biophysics
- Neuroscience
- Biochemistry and Chemical Biology
- Research focus
- ion channel structure
- ion channel mechanisms
- ion channel physiology
- ion channel pharmacology
- Experimental organism
- mouse
- Competing interests statement
- Kenton Swartz is employed by the Intramural Research Program of the National Institute of Neurological Disorders and Stroke, National Institutes of Health. In addition to serving as a Senior Editor at eLife, he has served as a Reviewing Editor for eLife and as an Associate Editor at the Journal of General Physiology. He also teaches yoga at LifeTime Athletic.
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Cynthia Wolberger
Johns Hopkins University School of Medicine, United States
Cynthia Wolberger is a Professor of Biophysics and Biophysical Chemistry at the Johns Hopkins University School of Medicine, whose faculty she joined in 1991. She received her AB in Physics from Cornell University and her PhD in Biophysics from Harvard University, where she did thesis work on the structural basis of protein-DNA interactions under the guidance of Steve Harrison and Mark Ptashne. After a postdoctoral fellowship at the University of California, San Francisco with Bob Stroud, she worked on the crystal structures of homeodomain-DNA complexes in the laboratory of Carl Pabo at Johns Hopkins. Her earlier worked focused on the structural basis for combinatorial regulation of gene expression and the molecular mechanisms of the sirtuin family of protein deacetylases. Her current research centers on the mechanisms by which ubiquitin plays a signaling role in transcription and the DNA damage response. Wolberger was a recipient of the David and Lucile Packard Fellowship for Science and Engineering, a March of Dimes–Basil O’Conor Starter Scholar Award, and an American Cancer Society Junior Faculty Award, and was a Howard Hughes Medical Institute Investigator from 1994–2014. She received the Protein Society’s Dorothy Crowfoot Hodgkin Award and is a Fellow of the American Association for the Advancement of Science. Dr. Wolberger is a member of the National Academy of Sciences and the American Academy of Arts and Sciences.
- Expertise
- Structural Biology and Molecular Biophysics
- Chromosomes and Gene Expression
- Biochemistry and Chemical Biology
- Research focus
- ubiquitin
- chromatin
- transcription
- post-translational modifications
- histone-modifying enzymes
- Competing interests statement
- Cynthia Wolberger receives funding from the National Institutes of Health , the US–Israel Binational Science Foundation, and the Emerson Collective. She serves on the scientific advisory boards of Thermo Fisher Scientific and the Max Planck Institute for Biochemistry in Martinsried, Germany. She is a member of the Editorial Advisory Board of Protein Science, the Editorial Boards of Structure and Current Opinion in Structural Biology, and is a Faculty of 1000 section head in Transcription and Translation.
Reviewing editors
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Jonathan Abraham
Harvard Medical School, United States
- Expertise
- Biochemistry and Chemical Biology
- Structural Biology and Molecular Biophysics
- Microbiology and Infectious Disease
- Medicine
- Research focus
- emerging viruses
- antibody neutralisation
- viral entry
- viral replication
- x-ray crystallography
- cryo-EM
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Hossein Ardehali
Northwestern University, United States
- Expertise
- Medicine
- Biochemistry and Chemical Biology
- Research focus
- mitochondria
- iron
- glucose metabolism
- mRNA-binding proteins
- hexokinases
- metabolism
- cardiac biology
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Nir Ben-Tal
Tel Aviv University, Israel
- Expertise
- Biochemistry and Chemical Biology
- Computational and Systems Biology
- Evolutionary Biology
- Structural Biology and Molecular Biophysics
- Research focus
- computational structural biology
- structural biology
- structural bioinformatics
- protein universe
- primordial peptides
- membrane proteins
- transporters
- drug discovery
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James Berger
Johns Hopkins University School of Medicine, United States
- Expertise
- Biochemistry and Chemical Biology
- Structural Biology and Molecular Biophysics
- Research focus
- x-ray crystallography
- electron microscopy
- biochemistry
- biophysics
- DNA replication
- ATPase mechanism
- DNA topology
- topoisomerases
- helicases
- Experimental organism
- B. subtilis
- D. melanogaster
- E. coli
- human
- S. cerevisiae
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Douglas L Black
University of California, Los Angeles, United States
- Expertise
- Biochemistry and Chemical Biology
- Chromosomes and Gene Expression
- Research focus
- RNA splicing
- alternative splicing
- RNA binding proteins
- post-transcriptional gene regulation
- neuronal gene expression
- neuronal development
- polypyrimidine tract binding proteins
- Rbfox proteins
- Experimental organism
- mammalian cells
- mouse
- ES cell models
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Amie K Boal
Pennsylvania State University, United States
- Expertise
- Biochemistry and Chemical Biology
- Structural Biology and Molecular Biophysics
- Research focus
- bioinorganic chemistry
- enzymes
- microbial chemistry
- x-ray crystallography
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Michael R Botchan
University of California, Berkeley, United States
- Expertise
- Biochemistry and Chemical Biology
- Chromosomes and Gene Expression
- Research focus
- DNA replication
- DNA repair
- Experimental organism
- D. melanogaster
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Agnieszka Chacinska
University of Warsaw, Poland
- Expertise
- Biochemistry and Chemical Biology
- Cell Biology
- Research focus
- biogenesis
- organelles
- mitochondria
- protein transport
- proteasome
- protein degradation
- protein synthesis
- Experimental organism
- S. cerevisiae
- mammalian cells
- nematode
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Pimchai Chaiyen
Vidyasirimedhi Institute of Science and Technology (VISTEC), Thailand
- Expertise
- Biochemistry and Chemical Biology
- Research focus
- Enzyme
- flavin
- mechanism
- biocatalysis
- metabolic engineering
- bioluminescence
- Experimental organism
- E. coli
- Pseudomonas
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Lydia Contreras
The University of Texas at Austin, United States
- Expertise
- Biochemistry and Chemical Biology
- Microbiology and Infectious Disease
- Research focus
- bacteria
- regulatory RNAs
- sRNAs
- bacterial regulation
- epitranscriptomics
- RNA modifications
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Ben Cravatt
Scripps Research Institute, United States
- Expertise
- Biochemistry and Chemical Biology
- Research focus
- chemical biology
- proteomics
- neurochemistry
- pharmacology
- Experimental organism
- human
- mouse
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Qiang Cui
Boston University, United States
- Expertise
- Biochemistry and Chemical Biology
- Structural Biology and Molecular Biophysics
- Research focus
- molecular dynamics
- hybrid quantum
- classical simulations
- enzyme catalysis
- allostery
- protein dynamics
- membrane remodeling
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Laura Dassama
Stanford University, United States
- Expertise
- Biochemistry and Chemical Biology
- Microbiology and Infectious Disease
- Research focus
- bacterial multidrug resistance
- chemoenzymatic syntheses
- beta-hemoglobinopathies
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Irwin Davidson
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/UDS, France
- Expertise
- Biochemistry and Chemical Biology
- Cancer Biology
- Chromosomes and Gene Expression
- Research focus
- transcription
- chromatin
- genomics
- cancer
- Experimental organism
- human
- mouse
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Roger J Davis
University of Massachusetts Medical School, United States
- Expertise
- Biochemistry and Chemical Biology
- Cancer Biology
- Cell Biology
- Research focus
- diabetes
- NAFLD
- NASH
- metabolism
- insulin resistance
- cancer
- signal transduction
- Experimental organism
- mouse
- human
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Ivan Dikic
Goethe University Frankfurt, Germany
- Expertise
- Biochemistry and Chemical Biology
- Cell Biology
- Research focus
- ubiquitination
- autophagy
- bacterial effectors
- Legionella
- ER-phagy
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David Drew
University of Stockholm, Sweden
- Expertise
- Biochemistry and Chemical Biology
- Structural Biology and Molecular Biophysics
- Research focus
- membrane transporters
- x-ray crystallography
- cryo-EM
- membrane protein biotechnology
- bioenergetics
- solute carrier (SLC) transport
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Stephen C Ekker
Mayo Clinic, United States
- Expertise
- Developmental Biology
- Biochemistry and Chemical Biology
- Research focus
- gene editing
- morpholinos
- transposons
- mitochondria
- health engineering
- Experimental organism
- zebrafish
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Aaron Frank
University of Michigan, United States
- Expertise
- Structural Biology and Molecular Biophysics
- Biochemistry and Chemical Biology
- Research focus
- molecular modeling
- biophysics
- structural biology
- computation
- RNA biochemistry
- RNA structural biology
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Adam Frost
University of California, San Francisco, United States
- Expertise
- Structural Biology and Molecular Biophysics
- Biochemistry and Chemical Biology
- Cell Biology
- Research focus
- cryo-EM
- electron cryo-microscopy
- membranes
- membrane remodeling
- proteostasis
- stress responses
- translation
- mitochondria
- nuclear envelope
- intracellular trafficking
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Karine A Gibbs
Harvard University, United States
- Expertise
- Microbiology and Infectious Disease
- Biochemistry and Chemical Biology
- Research focus
- Proteus mirabilis
- sociomicrobiology
- bacterial genetics
- kin discrimination
- self/non-self recognition
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Ruben Gonzalez
Columbia University, United States
- Expertise
- Biochemistry and Chemical Biology
- Structural Biology and Molecular Biophysics
- Research focus
- translation
- translational control
- ribosomes
- RNA
- tRNA
- single-molecule biophysics
- single-molecule fluorescence resonance energy transfer
- cryo-EM
- biochemistry
- live cell imaging
- Experimental organism
- B. subtilis
- E. coli
- human
- S. cerevisiae
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Rebekah L. Gundry
University of Nebraska Medical Center, United States
- Expertise
- Biochemistry and Chemical Biology
- Computational and Systems Biology
- Stem Cells and Regenerative Medicine
- Research focus
- mass spectrometry
- cell surface glycoproteins
- proteomics
- glycomics
- heart failure
- stem cell derived cardiomyocytes
- biomarkers
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Iqbal Hamza
University of Maryland, United States
- Expertise
- Biochemistry and Chemical Biology
- Cell Biology
- Genetics and Genomics
- Research focus
- metals
- anemia
- iron
- heme
- Experimental organism
- mouse
- C. elegans
- parasites
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Franz-Ulrich Hartl
Max Planck Institute of Biochemistry, Germany
- Expertise
- Biochemistry and Chemical Biology
- Structural Biology and Molecular Biophysics
- Research focus
- protein folding
- molecular chaperones
- neurodegenerative disorders
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Heedeok Hong
Michigan State University, United States
- Expertise
- Structural Biology and Molecular Biophysics
- Biochemistry and Chemical Biology
- Research focus
- membrane proteins
- membrane protein folding
- membrane protein stability
- rhomboid proteases
- ATP-dependent proteolysis
- AAA+
- GlpG
- FtsH
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Pankaj Kapahi
Buck Institute for Research on Aging, United States
- Expertise
- Biochemistry and Chemical Biology
- Developmental Biology
- Research focus
- aging
- age-related diseases
- nutrient signaling
- metabolism
- inflammation
- Experimental organism
- C. elegans
- D. melanogaster
- E. coli
- mouse
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Mary B Kennedy
California Institute of Technology, United States
- Expertise
- Biochemistry and Chemical Biology
- Computational and Systems Biology
- Neuroscience
- Research focus
- synaptic plasticity
- synaptic regulation
- biochemical signal transduction networks
- systems biology
- Experimental organism
- mouse
- rat
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Daniel J Kliebenstein
University of California, Davis, United States
- Expertise
- Biochemistry and Chemical Biology
- Computational and Systems Biology
- Ecology
- Genetics and Genomics
- Plant Biology
- Research focus
- genetics
- genomics
- transcriptomics
- metabolomics
- pathogen
- plant metabolism
- fitness
- Experimental organism
- A. thaliana
- B. cinerea
- eudicots
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Benoît Kornmann
University of Oxford, United Kingdom
- Expertise
- Biochemistry and Chemical Biology
- Cell Biology
- Genetics and Genomics
- Research focus
- membrane contact sites
- mitochondria
- membrane dynamics
- membrane trafficking
- phospholipids
- Experimental organism
- S. cerevisiae
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David M Kramer
Michigan State University, United States
- Expertise
- Biochemistry and Chemical Biology
- Plant Biology
- Physics of Living Systems
- Computational and Systems Biology
- Research focus
- photosynthesis
- bioenergetics
- electron and proton transfer
- computation
- phenotyping
- phenomics
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Yamuna Krishnan
University of Chicago, United States
- Expertise
- Biochemistry and Chemical Biology
- Research focus
- nucleic acid-based molecular devices
- DNA machines
- chemical biology
- synthetic biology
- bioengineering
- Experimental organism
- C. elegans
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Andrew C Kruse
Harvard Medical School, United States
- Expertise
- Structural Biology and Molecular Biophysics
- Biochemistry and Chemical Biology
- Research focus
- signal transduction
- G protein-coupled receptors (GPCR)
- membrane proteins
- x-ray crystallography
- molecular pharmacology
- yeast surface display
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Karsten Kruse
University of Geneva, Switzerland
- Expertise
- Biochemistry and Chemical Biology
- Physics of Living Systems
- Research focus
- cell migration
- cell signalling
- theoretical biology
- molecular evolution
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Tatiana G Kutateladze
University of Colorado School of Medicine, United States
- Expertise
- Biochemistry and Chemical Biology
- Structural Biology and Molecular Biophysics
- Research focus
- epigenetics
- chromatin
- protein structure
- NMR spectroscopy
- molecular mechanisms
- Experimental organism
- human
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Ashish Lal
National Institutes of Health, United States
- Expertise
- Cancer Biology
- Biochemistry and Chemical Biology
- Chromosomes and Gene Expression
- Genetics and Genomics
- Research focus
- RNA biology
- lncRNAs
- microRNAs
- gene regulation
- cancer biology
- p53
- Experimental organism
- human
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Joanne Lemieux
University of Alberta, United States
- Expertise
- Biochemistry and Chemical Biology
- Structural Biology and Molecular Biophysics
- Research focus
- protease
- intramembrane protease
- crystallography
- membrane proteins
- structural biology
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Hening Lin
Cornell University, United States
- Expertise
- Biochemistry and Chemical Biology
- Cell Biology
- Research focus
- sirtuin
- PARP
- diphthamide
- post-translational modifications
- proteomics
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Sebastian Lourido
Whitehead Institute for Biomedical Research, United States
- Expertise
- Microbiology and Infectious Disease
- Cell Biology
- Genetics and Genomics
- Biochemistry and Chemical Biology
- Research focus
- calcium signaling
- host-pathogen interactions
- genetic screening
- protein kinases
- genomics
- quantitative proteomics
- Apicomplexan parasites
- Experimental organism
- T. gondii
- P. falciparum
-
Andrei Lupas
Max Planck Institute for Developmental Biology, Germany
- Expertise
- Biochemistry and Chemical Biology
- Computational and Systems Biology
- Structural Biology and Molecular Biophysics
- Evolutionary Biology
- Research focus
- bacterial surface proteins
- bioinformatics
- coiled coils
- protein design
- protein evolution
- protein structure
- transmembrane signal tranduction
-
Koyeli Mapa
Shiv Nadar University, India
- Expertise
- Biochemistry and Chemical Biology
- Research focus
- proteostasis
- chaperones
- stress response
- unfolded protein response
- heat shock proteins
- mitochondria
- protein folding
- Experimental organism
- yeast
- human cells
- E. coli
-
Andreas Martin
University of California, Berkeley, United States
- Expertise
- Biochemistry and Chemical Biology
- Structural Biology and Molecular Biophysics
- Research focus
- AAA+ ATPases
- protein degradation
- proteostasis
- ATPase mechanism
- protein folding
-
Malcolm J McConville
University of Melbourne, Australia
- Expertise
- Microbiology and Infectious Disease
- Biochemistry and Chemical Biology
- Research focus
- protozoan parasites
- metabolomics
- metabolism
- Leishmaniasis
- trypanosomatids
- glycobiology
- Experimental organism
- T. gondii
-
Hitoshi Nakatogawa
Tokyo Institute of Technology, Japan
- Expertise
- Cell Biology
- Biochemistry and Chemical Biology
- Research focus
- molecular mechanisms of autophagy
- protein/organelle degradation
- membrane dynamics
- Experimental organism
- S. cerevisiae
-
Geeta Narlikar
University of California, San Francisco, United States
- Expertise
- Biochemistry and Chemical Biology
- Structural Biology and Molecular Biophysics
- Research focus
- chromatin
- heterochromatin spread
- chromatin remodeling machines
- phase-separation
-
Hannes Neuweiler
University of Würzburg, Germany
- Expertise
- Structural Biology and Molecular Biophysics
- Biochemistry and Chemical Biology
- Research focus
- protein folding
- protein dynamics
- protein engineering
- fluorescence spectroscopy
- fluorescence probes
- kinetics
- single-molecule fluorescence spectroscopy
-
Timothy Nilsen
Case Western Reserve University, United States
- Expertise
- Biochemistry and Chemical Biology
- Chromosomes and Gene Expression
- Research focus
- mRNA processing
- mechanism of miRNA function
- RNA protein interactions
- mRNP composition and function
- RNA biology
- Experimental organism
- D. melanogaster
-
Kassandra Ori-McKenney
University of California , United States
- Expertise
- Biochemistry and Chemical Biology
- Cell Biology
- Neuroscience
- Research focus
- microtubules
- microtubule-associated proteins
- microtubule motors
- tau neurofibrillary tangles
- neurodegeneration
- Experimental organism
- D. melanogaster
- mammalian cell culture
-
Kim Orth
University of Texas Southwestern Medical Center, United States
- Expertise
- Biochemistry and Chemical Biology
- Cell Biology
- Microbiology and Infectious Disease
- Research focus
- Vibrio
- T3SS
- virulence pathogenesis
- host-pathogen
- AMPylation
- Fic-domain
- Experimental organism
- Vibrio spp
-
Rohit V Pappu
Washington University in St Louis, United States
- Expertise
- Biochemistry and Chemical Biology
- Structural Biology and Molecular Biophysics
- Research focus
- biophysics
- intrinsically disordered proteins
- intracellular phase transition phenomena
- organization of proteins and nucleic acids
-
Maddy Parsons
King's College London, United Kingdom
- Expertise
- Biochemistry and Chemical Biology
- Cancer Biology
- Cell Biology
- Physics of Living Systems
- Research focus
- adhesion
- migration
- cytoskeleton
- receptor signalling
- extracellular matrix
- fibrosis
- cancer
- Experimental organism
- mouse
-
Federico Pelisch
University of Dundee, United Kingdom
- Expertise
- Cell Biology
- Biochemistry and Chemical Biology
- Research focus
- meiosis
- SUMO
- phosphorylation
- ubiquitin
- oocytes
- chromosome segregation
- Experimental organism
- C. elegans
-
Jon Pines
Institute of Cancer Research, University College London, United Kingdom
- Expertise
- Biochemistry and Chemical Biology
- Cell Biology
- Research focus
- cyclins and anaphase promoting complex/cycosome (APC/C)
- cell cycle
- mitosis
- spindle assembly checkpoint
- Experimental organism
- human
-
Stephan Pless
University of Copenhagen, Denmark
- Expertise
- Structural Biology and Molecular Biophysics
- Biochemistry and Chemical Biology
- Research focus
- ion channels
- pharmacology
- electrophysiology
- biophysics
- chemical biology
- non-canonical amino acids
- protein engineering
- neurobiology
-
Arun Radhakrishnan
University of Texas Southwestern Medical Center, United States
- Expertise
- Biochemistry and Chemical Biology
- Cell Biology
- Structural Biology and Molecular Biophysics
- Research focus
- lipid sensors
- cholesterol
- sphingomyelin
- cholesterol transport
- SREBP
- Scap
- cholesterol homeostasis
- endoplasmic reticulum
- Experimental organism
- E. coli
- human
- mouse
-
Michael Rape
University of California, Berkeley, United States
- Expertise
- Biochemistry and Chemical Biology
- Cell Biology
- Developmental Biology
- Research focus
- ubiquitin
- quality control
- protein aggregation
- mitochondria
- proteasome
- Experimental organism
- human
- mouse
-
Frank Raushel
Texas A&M University, United States
- Expertise
- Biochemistry and Chemical Biology
- Research focus
- bioorganic chemistry
- enzyme catalysis
- chemical biology
- enzyme engineering
-
Janice L Robertson
Washington University in St. Louis, United States
- Expertise
- Structural Biology and Molecular Biophysics
- Computational and Systems Biology
- Physics of Living Systems
- Biochemistry and Chemical Biology
- Research focus
- membrane protein folding
- computational modeling
- oligomerization
- membrane transport
- driving forces
- lipids
-
Rajan Sankaranarayanan
CSIR – Centre for Cellular and Molecular Biology, India
- Expertise
- Biochemistry and Chemical Biology
- Structural Biology and Molecular Biophysics
- Research focus
- crystal structure
- mechanism
- translation of genetic code
- proofreading
- editing
- tRNA synthetase
- Experimental organism
- E. coli
-
Tricia Serio
The University of Massachusetts, Amherst, United States
- Expertise
- Biochemistry and Chemical Biology
- Cell Biology
- Research focus
- protein folding/misfolding
- prions
- chaperones
- protein homeostasis
- protein quality control
- amyloid
- Experimental organism
- S. cerevisiae
-
Nima Sharifi
Cleveland Clinic, United States
- Expertise
- Biochemistry and Chemical Biology
- Cancer Biology
- Medicine
- Research focus
- steroid biochemistry
- steroid metabolism
- prostate cancer
- nuclear receptors
- hormone therapy resistance
- androgens
- oncology
- Experimental organism
- mouse
-
Akira Shinohara
Osaka University, Japan
- Expertise
- Biochemistry and Chemical Biology
- Chromosomes and Gene Expression
- Cell Biology
- Research focus
- recombination
- DSB repair
- meiosis
- chromosome
- DNA damage response
- Experimental organism
- S. cerevisiae
- human
- mouse
-
Gustavo Monteiro Silva
Duke University, United States
- Expertise
- Biochemistry and Chemical Biology
- Research focus
- ubiquitin
- oxidative stress
- translation
- proteomics
- Experimental organism
- human
- mouse
- S. cerevisiae
-
Maria Spies
University of Iowa, United States
- Expertise
- Biochemistry and Chemical Biology
- Cancer Biology
- Chromosomes and Gene Expression
- Structural Biology and Molecular Biophysics
- Research focus
- single-molecule biophysics
- DNA repair
- DNA replication
- DNA recombination
- genome stability
- protein dynamics
- protein-nucleic acids interactions
- drug discovery
- Experimental organism
- human
- yeast
- bacteria
-
Jonathan P Staley
University of Chicago, United States
- Expertise
- Biochemistry and Chemical Biology
- Chromosomes and Gene Expression
- Genetics and Genomics
- Research focus
- splicing
- spliceosome
- intron
- exon
- splice site
- co-transcriptional
- Experimental organism
- budding yeast
- mammalian cell culture
-
Randy B Stockbridge
University of Michigan, United States
- Expertise
- Biochemistry and Chemical Biology
- Structural Biology and Molecular Biophysics
- Research focus
- ion channels
- transporters
- microbial membrane proteins
- crystallography
- electrophysiology
- Experimental organism
- E. coli
-
Thomas Surrey
The Francis Crick Institute, United Kingdom
- Expertise
- Biochemistry and Chemical Biology
- Cell Biology
- Structural Biology and Molecular Biophysics
- Research focus
- cytoskeleton
- spindle assembly
- cell division
- motor proteins
- microtubules
- self-organization
- active networks
- Experimental organism
- human
-
Ivan Topisirovic
Jewish General Hospital, Canada
- Expertise
- Biochemistry and Chemical Biology
- Cancer Biology
- Cell Biology
- Research focus
- mRNA translation
- signaling
- metabolic regulation
- protein quality control
- Experimental organism
- mouse
- human
-
Eric J Wagner
University of Texas Medical Branch at Galveston, United States
- Expertise
- Chromosomes and Gene Expression
- Biochemistry and Chemical Biology
- Cancer Biology
- Genetics and Genomics
- Research focus
- RNA biology
- transcription
- RNA processing
- gene expression
-
Oliver Weichenrieder
Max Planck Institute for Developmental Biology, Germany
- Expertise
- Biochemistry and Chemical Biology
- Structural Biology and Molecular Biophysics
- Genetics and Genomics
- Research focus
- retrotransposition
- regulatory mRNA
- x-ray crystallography
- structural biology
-
William I Weis
Stanford University, United States
- Expertise
- Biochemistry and Chemical Biology
- Structural Biology and Molecular Biophysics
- Research focus
- cell adhesion
- wnt signaling
- X-ray crystallography
- structural biology
- Experimental organism
- C. elegans
- Dictyostelium
- human
- mouse
-
Julie P I Welburn
University of Edinburgh, United Kingdom
- Expertise
- Biochemistry and Chemical Biology
- Cell Biology
- Structural Biology and Molecular Biophysics
- Research focus
- mitosis
- cytoskeleton
- motors
- phosphorylation
- kinase
- microtubule
- cilia
- kinetochore
- Experimental organism
- human
- in vitro
-
Raymund Wellinger
Université de Sherbrooke, Canada
- Expertise
- Biochemistry and Chemical Biology
- Cell Biology
- Chromosomes and Gene Expression
- Genetics and Genomics
- Research focus
- chromosome biology
- DNA replication
- telomeres
- telomerase
- yeast cell biology
- Experimental organism
- yeast
- mouse
-
Jie Xiao
Johns Hopkins University, United States
- Expertise
- Biochemistry and Chemical Biology
- Cell Biology
- Chromosomes and Gene Expression
- Microbiology and Infectious Disease
- Physics of Living Systems
- Structural Biology and Molecular Biophysics
- Research focus
- single molecule biophysics
- microbiology
- cell division
- cell wall
- gene expression
- Experimental organism
- E. coli
-
Gary Yellen
Harvard Medical School, United States
- Expertise
- Biochemistry and Chemical Biology
- Cell Biology
- Physics of Living Systems
- Research focus
- neuronal metabolism
- control of energy metabolism
- fluorescent biosensors
- metabolic control of excitability
- Experimental organism
- mouse
-
Ahmet Yildiz
University of California, Berkeley, United States
- Expertise
- Biochemistry and Chemical Biology
- Physics of Living Systems
- Research focus
- dynein
- kinesin
- myosin
- intraflagellar transport
- Experimental organism
- human
- yeast
- Chlamydomonas
-
Giulia Zanetti
Birkbeck, University of London, United Kingdom
- Expertise
- Biochemistry and Chemical Biology
- Cell Biology
- Structural Biology and Molecular Biophysics
- Research focus
- membrane trafficking
- coat proteins
- COPII
- membrane remodeling
- structural biology
- cryo-EM
- cryo-ET
- subtomogram averaging
- Experimental organism
- S. cerevisiae
-
Mingjie Zhang
Hong Kong University of Science and Technology, Hong Kong SAR China
- Expertise
- Biochemistry and Chemical Biology
- Structural Biology and Molecular Biophysics
- Research focus
- postsynaptic density
- synaptic signaling
- scaffold proteins
- liquid-liquid phase separation
- biological condensates