Editors for Biochemistry and Chemical Biology

The working scientists who serve as eLife editors, our early-career advisors, governing board, and our executive staff all work in concert to realise eLife’s mission to accelerate discovery

Senior editors

  1. Philip Cole

    Senior Editor

    Phil Cole is Professor of Medicine and Biological Chemistry and Molecular Pharmacology at Harvard Medical School and is a Senior Investigator in the Division of Genetics at Brigham and Women's Hospital. He graduated from Yale University with a B.S. in Chemistry and then spent a year as a Churchill Scholar at the University of Cambridge prior to obtaining M.D. and Ph.D. degrees from Johns Hopkins School of Medicine where he pursued research in bioorganic chemistry. Cole then entered post-doctoral and clinical training at Harvard Medical School and Brigham and Women's Hospital. He subsequently held faculty positions at Rockefeller University and then Johns Hopkins where he was Chair of Pharmacology prior to returning to Harvard in 2017. His research interests are related to the chemical biology of cell signaling and epigenetics. His group has developed and applied methods for protein semisynthesis and small molecule probes for kinases, acyltransferases, deacetylases, and demethylases. His honors include election to the ASCI, fellow of the AAAS, and receipt of an NIH MERIT award.

    Expertise
    Biochemistry and Chemical Biology
    Research focus
    chemical biology
    signal transduction
    epigenetics
  2. Ivan Dikic

    Senior Editor

    Ivan Dikic is a Professor and Chairman of Institute of Biochemistry II at the Medical School Goethe University and a member of the Buchmann Institute for Molecular Life Sciences in Frankfurt. He was trained as a medical doctor at Zagreb University and obtained his PhD in molecular biology with Joseph Schlessinger. His career is focused on studying intracellular signaling initially via protein tyrosine kinases where he revealed how multiple monoubiquitination controls EGFR endocytosis. His lab has pioneered a concept of Ubiquitin as a multivalent cellular signal that regulates multitude of physiological and pathophysiological processes including DNA repair, inflammation, cancer, infection and proteasomal degradation. Ivan’s group also provided structural and functional evidence for a new type of Ub chains that are Met1-linked (called linear ubiquitination) in promoting the NF-kB signaling. His current interests focus on selective autophagy, which is essential for the clearance of protein aggregates, pathogens, and damaged mitochondria from the cell. He has received many awards for his work including the AACR Award for Outstanding Achievement in Cancer Research, the Award of European Association for Cancer Research, the Hans Krebs Prize, the Leibniz Award and the Ernst Jung Award in Medicine. He is a Member of the German Academy for Sciences Leopoldina, Academia Europaea, Croatian Academy of Medical Sciences and the European Molecular Biology Organization.

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Research focus
    ubiquitination
    autophagy
    endocytosis
    inflammation
    cancer biology
  3. John Kuriyan

    John Kuriyan

    Senior Editor

    John Kuriyan is Professor of Molecular and Cell Biology and also of Chemistry at the University of California, Berkeley. Before this, he was on the faculty at The Rockefeller University, New York, where he began his career in 1987, leaving for Berkeley in 2001. Since 1990, he has been an Investigator of the Howard Hughes Medical Institute. Kuriyan completed undergraduate studies in chemistry at Juniata College, Huntingdon, PA. His doctoral research, on the dynamics of proteins, was carried out at MIT, under the guidance of Greg Petsko and Martin Karplus (Harvard University). Kuriyan’s research is aimed at understanding the structure and mechanism of the enzymes and molecular switches that carry out cellular signal transduction and DNA replication. His laboratory uses x-ray crystallography to determine the three-dimensional structures of proteins involved in signaling and replication, as well as biochemical, biophysical, and computational analyses to elucidate mechanisms. Kuriyan was elected to the US National Academy of Sciences in 2001.

    Expertise
    Biochemistry and Chemical Biology
    Biophysics and Structural Biology
    Research focus
    protein science and biochemistry
    signaling
    crystallography
    electron microscopy
    modeling
    molecular dynamics
  4. Wenhui Li

    Wenhui Li

    Senior Editor

    Wenhui Li is an Investigator of the National Institute of Biological Sciences (NIBS), Beijing, China. He received a bachelor’s degree in medicine from the Medical School of Lanzhou University in 1994 and his PhD from the Peking Union Medical College & Chinese Academy of Medical Sciences in 2001. After completing his postdoctoral studies at Harvard Medical School, Li joined NIBS as an Assistant Investigator in 2007 and rose to the rank of Investigator in 2015. His team at NIBS identified a liver bile acids transporter (sodium taurocholate co-transporting polypeptide, NTCP) as a functional receptor for Hepatitis B and D virus. Li’s research interest has been focusing on the molecular mechanisms of viral infections: currently his laboratory combines virology, biochemistry, immunology, and chemical biology to investigate molecular mechanisms of HBV/HDV infection.

    Expertise
    Biochemistry and Chemical Biology
    Microbiology and Infectious Disease
    Research focus
    virus infection
    hepatitis b/d virus
    receptor
    antivirals
  5. Vivek Malhotra

    Senior Editor

    Vivek Malhotra was a professor in the biology division at UC San Diego from 2007 and is now the ICREA Professor and Chair of the Cell and Developmental Biology at Center for Genomic Regulation (CRG) in Barcelona. His research focuses on a central station of the secretory pathway, the Golgi complex. Specifically, his work has resulted in the identification of the machinery required for the sorting and packaging of secretory cargoes. His recent work has uncovered a novel secretory routing that bypasses the conventional pathway of protein secretion. He has identified new genes required for the export of bulky collagens and the regulated secretion of mucins. He received his BSc from Stirling University and was a Pirie–Reid scholar at Oxford; a Damon Runyon Walter Winchell and an American Cancer Society postdoctoral fellow at Stanford; and Basil O’Conner scholar, established Investigator of the American Heart Association, and Senior Investigator of Sandler’s Foundation for Asthma at UC San Diego. He received the MERCK award from the American Society of Biochemistry and Molecular Biology, is a fellow of the American association of the arts and science, and is an elected EMBO member.

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Research focus
    Golgi apparatus: biogenesis, structure, and function
    Collagen and Mucin secretion
  6. Michael Marletta

    Michael Marletta

    Senior Editor

    Michael Marletta is the Aldo DeBenedictis Distinguished Professor of Chemistry and of Biochemistry and Molecular Biology at the University of California, Berkeley. Previous to his appointment at UC Berkeley, he was a former President and CEO of The Scripps Research Institute. He has also been on the faculty of the University of Michigan, where he was an HHMI Investigator, and MIT. Marletta obtained an A.B. in chemistry and biology from the State University of New York at Fredonia, a Ph.D. from UCSF under George Kenyon and, after a postdoctoral appointment at MIT under Chris Walsh, began his independent career. His work has spanned protein chemistry and enzymology. He has made many contributions to our understanding of nitric oxide signaling and more generally in molecular mechanisms of gas sensing in eukaryotes and prokaryotes. More recent studies have involved novel enzymes involved with cellulose degradation. Marletta is a member of the National Academy of Sciences, the Institute of Medicine, and the American Academy of Arts and Sciences.

    Expertise
    Biochemistry and Chemical Biology
    Research focus
    chemical biology
    nitric oxide signaling
    gas sensing
    structural basis of enzyme activity
  7. Andrea Musacchio

    Senior Editor

    Andrea Musacchio is Director of the Department of Mechanistic Cell Biology at the Max Planck Institute of Molecular Physiology in Dortmund (Germany) since 2011, and he is also adjunct professor at the University of Duisburg-Essen. Before this, he worked at the European Institute of Oncology in Milan (Italy), where he established his first laboratory as an independent investigator in 1999. Musacchio completed undergraduate studies at the University of Rome-Tor Vergata and moved for his graduate studies to the EMBL in Heidelberg, working under the guidance of Dr. Matti Saraste on the structural analysis of signalling domains. He later moved to do his postdoctoral training at the Harvard Medical School under the guidance of Prof. Stephen C. Harrison, working on structures of clathrin. Work in the Musacchio laboratory focuses on the biochemical reconstitution, structural analysis, and functional investigation of kinetochores and centromeres, structures required for chromosome segregation during mitosis. Musacchio is EMBO Member since 2009.

    Expertise
    Cell Biology
    Biochemistry and Chemical Biology
    Biophysics and Structural Biology
    Research focus
    kinetochore
    cell cycle
    centromere

Reviewing editors

  1. Geeta Narlikar

    University of California, San Francisco, United States

    Expertise
    Biochemistry and Chemical Biology
    Biophysics and Structural Biology
    Research focus
    chromatin
    heterochromatin spread
    chromatin remodeling machines
  2. Jose Faraldo-Gomez

    National Heart, Lung and Blood Institute, National Institutes of Health, United States

    Expertise
    Biochemistry and Chemical Biology
    Biophysics and Structural Biology
    Research focus
    Computational biophysics
    molecular computation
    membrane proteins
  3. Kavitha Sarma

    Wistar Institute, United States

    Expertise
    Biochemistry and Chemical Biology
    Genes and Chromosomes
    Research focus
    epigenetics
    chromatin
    noncoding RNA
    Experimental organism
    human
    mouse
  4. Hitoshi Nakatogawa

    Kyoto University, Japan

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Research focus
    yeast autophagy
    autophagy
    protein/organelle degradation
    membrane dynamics
    molecular mechanisms
    Experimental organism
    S. cerevisiae
  5. James Berger

    Johns Hopkins University School of Medicine, United States

    Expertise
    Biochemistry and Chemical Biology
    Biophysics and Structural Biology
    Research focus
    x-ray crystallography
    microscopy
    biochemistry
    biophysics
    DNA replication
    ATPase mechanism
    DNA topology
    topoisomerases
    helicases
  6. Douglas L Black

    University of California, Los Angeles, United States

    Expertise
    Biochemistry and Chemical Biology
    Genes and Chromosomes
    Research focus
    pre-mRNA splicing
    post-transcriptional gene regulation
  7. Michael R Botchan

    University of California, Berkeley, United States

    Expertise
    Biochemistry and Chemical Biology
    Genes and Chromosomes
    Research focus
    DNA replication
    DNA repair
    Experimental organism
    Drosophila
  8. Agnieszka Chacinska

    University of Warsaw, Poland

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Research focus
    mitochondria
    organelles
    protein biogenesis
    protein degradation
    protein transport
    Experimental organism
    human
    S. cerevisiae
  9. Jon Clardy

    Harvard Medical School, United States

    Expertise
    Biochemistry and Chemical Biology
    Ecology
    Microbiology and Infectious Disease
    Research focus
    microbial secondary metabolism
    chemical communications
    biosensors
    chemical biology
    microbial ecology and evolution
  10. Ben Cravatt

    Scripps Research Institute, United States

    Expertise
    Biochemistry and Chemical Biology
    Research focus
    chemical biology
    neurochemistry
    pharmacology
  11. Irwin Davidson

    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/UDS, France

    Expertise
    Biochemistry and Chemical Biology
    Cancer Biology
    Genes and Chromosomes
    Research focus
    transcription
    chromatin
    cancer
  12. Raymond J Deshaies

    California Institute of Technology, United States

    Expertise
    Biochemistry and Chemical Biology
    Research focus
    protein degradation
    proteasome
    proteolysis
    ubiquitin
  13. Paul G Falkowski

    Rutgers University, United States

    Expertise
    Biochemistry and Chemical Biology
    Biophysics and Structural Biology
    Ecology
    Research focus
    coral biology
    biogeochemical cycles
    biological oceanography
    evolution of photosynthesis
    physiological adaptation
    symbiosis
  14. Reid Gilmore

    University of Massachusetts Medical School, United States

    Expertise
    Biochemistry and Chemical Biology
    Research focus
    endoplasmic reticulum
    protein translocation
  15. Rachel Green

    Johns Hopkins University School of Medicine, United States

    Expertise
    Biochemistry and Chemical Biology
    Genes and Chromosomes
    Research focus
    mechanism of translation (bacterial and eukaryotic)
    ribosome profiling
    mRNA decay
    translational control
    ribosomes
  16. Nikolaus Grigorieff

    Janelia Research Campus, United States

    Expertise
    Biochemistry and Chemical Biology
    Biophysics and Structural Biology
    Research focus
    cryo-EM
    image processing
  17. Franz-Ulrich Hartl

    Max Planck Institute of Biochemistry, Germany

    Expertise
    Biochemistry and Chemical Biology
    Biophysics and Structural Biology
    Research focus
    protein folding
    molecular chaperones
    neurodegenerative disorders
  18. Manajit Hayer-Hartl

    Max Planck Institute of Biochemistry, Germany

    Expertise
    Biochemistry and Chemical Biology
    Biophysics and Structural Biology
    Research focus
    molecular chaperones
    protein folding and assembly
    protein misfolding and aggregation
    molecular machines
  19. Ramanujan S Hegde

    Medical Research Council Laboratory of Molecular Biology, United Kingdom

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Research focus
    protein translocation
    endoplasmic reticulum
    quality control
    protein degradation
    membrane protein insertion
    protein aggregation
    in vitro reconstitution
  20. Helen Hobbs

    UT Southwestern Medical Center, United States

    Expertise
    Biochemistry and Chemical Biology
    Human Biology and Medicine
    Research focus
    lipid metabolism
    cholesterol
    human genetics
    atherosclerosis
  21. Mary B Kennedy

    California Institute of Technology, United States

    Expertise
    Biochemistry and Chemical Biology
    Computational and Systems Biology
    Neuroscience
    Research focus
    synaptic plasticity
    synaptic regulation
    biochemical signal transduction networks
    systems biology
  22. Stephen C Kowalczykowski

    University of California, Davis, United States

    Expertise
    Biochemistry and Chemical Biology
    Biophysics and Structural Biology
    Genes and Chromosomes
    Research focus
    recombinational DNA repair
    single-molecule biophysics
    DNA-protein interactions
    Experimental organism
    E. coli
    S. cerevisiae
    human
  23. Werner Kuhlbrandt

    Max Planck Institute for Biophysics, Germany

    Expertise
    Biochemistry and Chemical Biology
    Biophysics and Structural Biology
    Cell Biology
    Research focus
    membrane protein structure and function
    membrane transporters
    macromolecular complexes
    molecular bioenergetics
    cryo-EM
  24. Andreas Martin

    University of California, Berkeley, United States

    Expertise
    Biochemistry and Chemical Biology
    Biophysics and Structural Biology
    Research focus
    AAA+ ATPases
    protein degradation
    ATPase mechanism
    protein folding
  25. Noboru Mizushima

    University of Tokyo, Japan

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Research focus
    protein degradation
    lysosome
    autophagy
  26. Davis Ng

    Temasek Life Sciences Laboratory and National University of Singapore, Singapore

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Research focus
    protein folding in the secretory pathway
    regulation of organelle homeostasis
    stress tolerance mechanisms
  27. Timothy Nilsen

    Case Western Reserve University, United States

    Expertise
    Biochemistry and Chemical Biology
    Genes and Chromosomes
    Research focus
    mRNA processing
    mechanism of miRNA function
    RNA protein interactions
    mRNP composition and function
    RNA biology
    Experimental organism
    Drosophila
  28. Jon Pines

    University College London, United Kingdom

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Research focus
    cyclins and anaphase promoting complex/cycosome (APC/C)
    cell cycle
    mitosis
    spindle assembly checkpoint
  29. Michael Rape

    UC Berkeley, United States

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Research focus
    ubiquitin
    mitosis
  30. David Ron

    Cambridge University, United Kingdom

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Research focus
    chaperones
    unfolded protein response
    oxidative protein folding
    protein synthesis
  31. Ali Shilatifard

    Northwestern University Feinberg School of Medicine, United States

    Expertise
    Biochemistry and Chemical Biology
    Cancer Biology
    Genes and Chromosomes
    Research focus
    chromatin
    ELLs
    P-TEFb
    pol II
    MLLs
    chromosomal translocations and leukemia
    enhancers
    gene expression
    transcription
    Experimental organism
    Drosophila
  32. Gary Stacey

    University of Missouri, United States

    Expertise
    Biochemistry and Chemical Biology
    Plant Biology
    Research focus
    plant development
    host-microbe interactions
    extracellular ATP
    peptide transport
    Experimental organism
    soybean
  33. Wilfred van der Donk

    University of Illinois at Urbana Champaign, United States

    Expertise
    Biochemistry and Chemical Biology
    Research focus
    enzymology
    chemical biology
    natural product biosynthesis
    cyclic peptides
    antibiotics
  34. Antoine M van Oijen

    University of Wollongong, Australia

    Expertise
    Biochemistry and Chemical Biology
    Biophysics and Structural Biology
    Research focus
    single-molecule biophysics
    protein-DNA interactions
    DNA replication
    DNA repair
  35. Oliver Weichenrieder

    Max Planck Institute for Developmental Biology, Germany

    Expertise
    Biochemistry and Chemical Biology
    Biophysics and Structural Biology
    Genomics and Evolutionary Biology
    Research focus
    retrotransposition
    regulatory mRNA
    x-ray crystallography
    structural biology
  36. William I Weis

    Stanford University, United States

    Expertise
    Biochemistry and Chemical Biology
    Biophysics and Structural Biology
    Research focus
    cell adhesion
    wnt signaling
    x-ray crystallography
    structural biology
  37. Stephen G Young

    University of California, Los Angeles, United States

    Expertise
    Biochemistry and Chemical Biology
    Human Biology and Medicine
    Research focus
    atherosclerosis
    lipoproteins
    nuclear lamins
    triglyceride metabolism
    cholesterol metabolism
  38. Mingjie Zhang

    Hong Kong University of Science and Technology, Hong Kong SAR China

    Expertise
    Biochemistry and Chemical Biology
    Biophysics and Structural Biology
    Research focus
    structural biology
    neuronal development and signaling
    cell polarity
    scaffold proteins