Editors for Biochemistry and Chemical Biology

We aim to publish studies that provide new mechanistic insights into the structure, function, and regulation of biological molecules including proteins, nucleic acids, lipids, carbohydrates, and natural products. In addition, we are interested in studies that illuminate complex biological processes using chemical tools and approaches. Read the latest research in this subject area.

Senior editors

  1. Philip Cole

    Harvard Medical School, United States

    Phil Cole is Professor of Medicine and Biological Chemistry and Molecular Pharmacology at Harvard Medical School and is a Senior Investigator in the Division of Genetics at Brigham and Women's Hospital. He graduated from Yale University with a B.S. in Chemistry and then spent a year as a Churchill Scholar at the University of Cambridge prior to obtaining M.D. and Ph.D. degrees from Johns Hopkins School of Medicine where he pursued research in bioorganic chemistry. Cole then entered post-doctoral and clinical training at Harvard Medical School and Brigham and Women's Hospital. He subsequently held faculty positions at Rockefeller University and then Johns Hopkins where he was Chair of Pharmacology prior to returning to Harvard in 2017. His research interests are related to the chemical biology of cell signaling and epigenetics. His group has developed and applied methods for protein semisynthesis and small molecule probes for kinases, acyltransferases, deacetylases, and demethylases. His honors include election to the ASCI, fellow of the AAAS, and receipt of an NIH MERIT award.

    Expertise
    Biochemistry and Chemical Biology
    Research focus
    chemical biology
    signal transduction
    epigenetics
    Competing interests statement
    Philip Cole is on the Scientific Advisory Boards of Memorial Sloan-Kettering Cancer Center, the Maryland Institute of Bioscience and Biotechnology Research, and the Searle Scholars Program. He is a cofounder of Acylin Therapeutics Inc and a science advisor for the Abbvie, Epizyme, and Forma companies and has been a consultant for MPM Capital. Cole has received research funding from the NIH, the FAMRI foundation, and the V Foundation. He is a member of the editorial boards of the following journals: J Biol Chem, Biomed Central Biology, ChemBioChem, and Bioorganic Chemistry.
  2. John Kuriyan

    John Kuriyan

    University of California, Berkeley, United States

    John Kuriyan is Professor of Molecular and Cell Biology and also of Chemistry at the University of California, Berkeley. Before this, he was on the faculty at The Rockefeller University, New York, where he began his career in 1987, leaving for Berkeley in 2001. Since 1990, he has been an Investigator of the Howard Hughes Medical Institute. Kuriyan completed undergraduate studies in chemistry at Juniata College, Huntingdon, PA. His doctoral research, on the dynamics of proteins, was carried out at MIT, under the guidance of Greg Petsko and Martin Karplus (Harvard University). Kuriyan’s research is aimed at understanding the structure and mechanism of the enzymes and molecular switches that carry out cellular signal transduction and DNA replication. His laboratory uses x-ray crystallography to determine the three-dimensional structures of proteins involved in signaling and replication, as well as biochemical, biophysical, and computational analyses to elucidate mechanisms. Kuriyan was elected to the US National Academy of Sciences in 2001.

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    protein science and biochemistry
    signaling
    crystallography
    electron microscopy
    modeling
    molecular dynamics
    Competing interests statement
    John Kuriyan has received funding from the Howard Hughes Medical Institute, the US National Institutes of Health, and the Leukemia and Lymphoma Society. He serves on the editorial board of the Proceedings of the National Academy of Sciences, and on the Scientific Advisory Boards of Carmot Therapeutics (San Francisco) and Jubilant Biosys (Bangalore). He is a founder of Nurix (San Francisco).
  3. Vivek Malhotra

    The Barcelona Institute of Science and Technology, Spain

    Vivek Malhotra was a professor in the biology division at UC San Diego from 2007 and is now the ICREA Professor and Chair of the Cell and Developmental Biology at Center for Genomic Regulation (CRG) in Barcelona. His research focuses on a central station of the secretory pathway, the Golgi complex. Specifically, his work has resulted in the identification of the machinery required for the sorting and packaging of secretory cargoes. His recent work has uncovered a novel secretory routing that bypasses the conventional pathway of protein secretion. He has identified new genes required for the export of bulky collagens and the regulated secretion of mucins. He received his BSc from Stirling University and was a Pirie–Reid scholar at Oxford; a Damon Runyon Walter Winchell and an American Cancer Society postdoctoral fellow at Stanford; and Basil O’Conner scholar, established Investigator of the American Heart Association, and Senior Investigator of Sandler’s Foundation for Asthma at UC San Diego. He received the MERCK award from the American Society of Biochemistry and Molecular Biology, is a fellow of the American association of the arts and science, and is an elected EMBO member.

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Research focus
    Golgi apparatus: biogenesis, structure, and function
    Collagen and Mucin secretion
    Competing interests statement
    Vivek Malhotra receives funding from ERC/European Research Council, Ministerio de Economía y Competitividad, AGAUR and the Plan Nacional (Spain) He is a Scientific Advisory Board member of TIGEM (Naples, Italy), CNR (Naples, Italy), CBMSO (Madrid, Spain) and Department of Biotechnology (India). He has served on the editorial board of Cell and was an associate editor of Molecular Biology of the Cell. He is currently on the editorial boards of Journal of Cell Biology and Current Opinion in Cell Biology.
  4. Michael Marletta

    Michael Marletta

    University of California, Berkeley, United States

    Michael Marletta is the Aldo DeBenedictis Distinguished Professor of Chemistry and of Biochemistry and Molecular Biology at the University of California, Berkeley. Previous to his appointment at UC Berkeley, he was a former President and CEO of The Scripps Research Institute. He has also been on the faculty of the University of Michigan, where he was an HHMI Investigator, and MIT. Marletta obtained an A.B. in chemistry and biology from the State University of New York at Fredonia, a Ph.D. from UCSF under George Kenyon and, after a postdoctoral appointment at MIT under Chris Walsh, began his independent career. His work has spanned protein chemistry and enzymology. He has made many contributions to our understanding of nitric oxide signaling and more generally in molecular mechanisms of gas sensing in eukaryotes and prokaryotes. More recent studies have involved novel enzymes involved with cellulose degradation. Marletta is a member of the National Academy of Sciences, the Institute of Medicine, and the American Academy of Arts and Sciences.

    Expertise
    Biochemistry and Chemical Biology
    Research focus
    chemical biology
    nitric oxide signaling
    gas sensing
    structural basis of enzyme activity
    Experimental organism
    E. coli
    human
    Competing interests statement
    Michael Marletta has received funding from the NIH, HHMI, and Burroughs-Wellcome Fund. He was a member of the PNAS Editorial Board (until July 2012) and Biochemistry. He is a Scientific Advisory Board member of Lycera, Inc., Galleon Pharmaceuticals, Viamet Pharmaceuticals, and N30. He serves on the Scientific Review Board of HHMI. He is an External Review Board member of the Vanderbilt Institute of Chemical Biology, Georgia Tech School of Chemistry and Biochemistry, and Chair, Natural Science Advisory Council, SUNY Fredonia. He is a co-founder of Omniox, Inc.
  5. David Ron

    Cambridge University, United Kingdom

    David Ron is a Professor at Cambridge University. He directs a lab at the Cambridge Institute for Medical Research (CIMR) studying protein-folding homeostasis in the endoplasmic reticulum (ER). The lab uses biochemical, biophysical and cell-based tools to research both the molecular mechanisms that recognize the burden of unfolded proteins and thus initiate signalling in the ER unfolded protein response (UPR) and the downstream effector pathways by which cells adapt to unfolded protein stress in their ER. These effector mechanisms engage post-translational regulation of ER chaperone function, regulated translation of mRNA and transcriptional control of gene expression and thus interface with other cellular stress pathways.

    To eLife, David Ron brings scientific expertise in the study of the unfolded protein response, chaperone function and stress-induced regulation of mRNA translation and editorial experience from having served as an eLife Reviewing Editor since 2012.

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Research focus
    chaperones
    unfolded protein response
    oxidative protein folding
    protein synthesis
    Experimental organism
    C. elegans
    E. coli
    human
    mouse
    S. cerevisiae
    Competing interests statement
    David Ron holds a Wellcome Trust Principal Research Fellowship and is on the editorial advisory boards of J. Cell Science, PLOS Biology and EMBO J.
  6. Cynthia Wolberger

    Johns Hopkins University School of Medicine, United States

    Cynthia Wolberger is a Professor of Biophysics and Biophysical Chemistry at the Johns Hopkins University School of Medicine, whose faculty she joined in 1991. She received her AB in Physics from Cornell University and her PhD in Biophysics from Harvard University, where she did thesis work on the structural basis of protein-DNA interactions under the guidance of Steve Harrison and Mark Ptashne. After a postdoctoral fellowship at the University of California, San Francisco with Bob Stroud, she worked on the crystal structures of homeodomain-DNA complexes in the laboratory of Carl Pabo at Johns Hopkins. Her earlier worked focused on the structural basis for combinatorial regulation of gene expression and the molecular mechanisms of the sirtuin family of protein deacetylases. Her current research centers on the mechanisms by which ubiquitin plays a signaling role in transcription and the DNA damage response. Wolberger was a recipient of the David and Lucile Packard Fellowship for Science and Engineering, a March of Dimes–Basil O’Conor Starter Scholar Award, and an American Cancer Society Junior Faculty Award, and was a Howard Hughes Medical Institute Investigator from 1994–2014. She received the Protein Society’s Dorothy Crowfoot Hodgkin Award and is a Fellow of the American Association for the Advancement of Science.

    Expertise
    Structural Biology and Molecular Biophysics
    Chromosomes and Gene Expression
    Biochemistry and Chemical Biology
    Research focus
    x-ray crystallography
    enzymology
    transcriptional regulation
    ubiquitin signaling
    Competing interests statement
    Cynthia Wolberger receives funding from the National Institutes of Health and the US–Israel Binational Science Foundation. She chairs the Scientific Advisory Committee of the RCSB Protein Data Bank and is on the external scientific advisory boards of the Advanced Photon Source and the Max Planck Institute for Biochemistry in Martinsried, Germany. She is a member of the Editorial Advisory Board of Protein Science, the Editorial Boards of Structure and Current Opinion in Structural Biology, and is a Faculty of 1000 section head in Transcription and Translation. Wolberger is also a member of the Scientific Advisory Board of Thermo Fisher Scientific.

Reviewing editors

  1. James Berger

    Johns Hopkins University School of Medicine, United States

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    x-ray crystallography
    electron microscopy
    biochemistry
    biophysics
    DNA replication
    ATPase mechanism
    DNA topology
    topoisomerases
    helicases
    Experimental organism
    B. subtilis
    D. melanogaster
    E. coli
    human
    S. cerevisiae
  2. Douglas L Black

    University of California, Los Angeles, United States

    Expertise
    Biochemistry and Chemical Biology
    Chromosomes and Gene Expression
    Research focus
    RNA splicing
    alternative splicing
    RNA binding proteins
    post-transcriptional gene regulation
    neuronal gene expression
    neuronal development
    polypyrimidine tract binding proteins
    Rbfox proteins
    Experimental organism
    mammalian cells
    mouse
    ES cell models
  3. Michael R Botchan

    University of California, Berkeley, United States

    Expertise
    Biochemistry and Chemical Biology
    Chromosomes and Gene Expression
    Research focus
    DNA replication
    DNA repair
    Experimental organism
    D. melanogaster
  4. Agnieszka Chacinska

    University of Warsaw, Poland

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Research focus
    biogenesis
    organelles
    mitochondria
    protein transport
    proteasome
    protein degradation
    protein synthesis
    Experimental organism
    S. cerevisiae
    mammalian cells
    nematode
  5. Pimchai Chaiyen

    Vidyasirimedhi Institute of Science and Technology (VISTEC), Thailand

    Expertise
    Biochemistry and Chemical Biology
    Research focus
    enzyme catalysis
    enzyme engineering
    systems biocatalysis
    metabolic engineering
    synthetic biology
  6. Jon Clardy

    Harvard Medical School, United States

    Expertise
    Biochemistry and Chemical Biology
    Ecology
    Microbiology and Infectious Disease
    Research focus
    microbial secondary metabolism
    chemical communications
    biosynthesis
    chemical biology
    microbial chemical ecology
  7. Ben Cravatt

    Scripps Research Institute, United States

    Expertise
    Biochemistry and Chemical Biology
    Research focus
    chemical biology
    proteomics
    neurochemistry
    pharmacology
    Experimental organism
    human
    mouse
  8. Irwin Davidson

    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/UDS, France

    Expertise
    Biochemistry and Chemical Biology
    Cancer Biology
    Chromosomes and Gene Expression
    Research focus
    transcription
    chromatin
    genomics
    cancer
    Experimental organism
    human
    mouse
  9. Ivan Dikic

    Goethe University Frankfurt, Germany

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Research focus
    ubiquitination
    autophagy
    endocytosis
    inflammation
    cancer biology
  10. Jose Faraldo-Gomez

    National Heart, Lung and Blood Institute, National Institutes of Health, United States

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    Computational biophysics
    molecular computation
    membrane proteins
  11. Matthew Freeman

    University of Oxford, United Kingdom

    Expertise
    Cell Biology
    Biochemistry and Chemical Biology
    Research focus
    cell signalling
    trafficking
    quality control
    Experimental organism
    D. melanogaster
  12. Adam Frost

    University of California, San Francisco, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Biochemistry and Chemical Biology
    Cell Biology
    Research focus
    cryo-EM
    electron cryo-microscopy
    membranes
    membrane remodeling
    proteostasis
    stress responses
    translation
    mitochondria
    nuclear envelope
    intracellular trafficking
  13. Rachel Green

    Johns Hopkins University School of Medicine, United States

    Expertise
    Biochemistry and Chemical Biology
    Chromosomes and Gene Expression
    Research focus
    mechanism of translation (bacterial and eukaryotic)
    ribosome profiling
    mRNA decay
    translational control
    ribosomes
  14. Nikolaus Grigorieff

    Janelia Research Campus, United States

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    structural biology
    image processing
    biophysics
    electron microscopy
    cryo-EM
  15. Franz-Ulrich Hartl

    Max Planck Institute of Biochemistry, Germany

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    protein folding
    molecular chaperones
    neurodegenerative disorders
  16. Brandon Harvey

    NIDA/NIH, Intramural Research Program, United States

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Chromosomes and Gene Expression
    Immunology and Inflammation
    Neuroscience
    Research focus
    ER stress
    ER calcium
    neuroinflammation
    viral vector
    AAV
    CNS
    biomarkers
    primary neurons and glia
    Experimental organism
    rat
    mouse
    human cells
  17. Manajit Hayer-Hartl

    Max Planck Institute of Biochemistry, Germany

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    molecular chaperones
    protein folding and assembly
    protein misfolding and aggregation
    molecular machines
  18. Ramanujan S Hegde

    MRC Laboratory of Molecular Biology, United Kingdom

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Research focus
    protein translocation
    endoplasmic reticulum
    quality control
    protein degradation
    membrane protein insertion
    protein aggregation
    in vitro reconstitution
  19. David James

    University of Sydney, Australia

    Expertise
    Cell Biology
    Biochemistry and Chemical Biology
    Research focus
    diabetes
    metabolism
    insulin action
    protein phosphorylation
    signal transduction
    Experimental organism
    D. melanogaster
    human
    mouse
  20. Mary B Kennedy

    California Institute of Technology, United States

    Expertise
    Biochemistry and Chemical Biology
    Computational and Systems Biology
    Neuroscience
    Research focus
    synaptic plasticity
    synaptic regulation
    biochemical signal transduction networks
    systems biology
    Experimental organism
    mouse
    rat
  21. Yamuna Krishnan

    University of Chicago, United States

    Expertise
    Biochemistry and Chemical Biology
    Research focus
    nucleic acid-based molecular devices
    DNA machines
    chemical biology
    synthetic biology
    bioengineering
    Experimental organism
    C. elegans
  22. Werner Kühlbrandt

    Max Planck Institute for Biophysics, Germany

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Cell Biology
    Research focus
    membrane protein structure and function
    membrane transporters
    macromolecular complexes
    molecular bioenergetics
    membrane proteins
    cryo-EM
    Experimental organism
    E. coli
    S. cerevisiae
  23. Ashish Lal

    National Institutes of Health, United States

    Expertise
    Cancer Biology
    Biochemistry and Chemical Biology
    Chromosomes and Gene Expression
    Genetics and Genomics
    Research focus
    RNA biology
    lncRNAs
    microRNAs
    gene regulation
    cancer biology
    p53
    DNA damage
    Experimental organism
    human
  24. Andrei Lupas

    Max Planck Institute for Developmental Biology, Germany

    Expertise
    Computational and Systems Biology
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    bacterial surface proteins
    bioinformatics
    coiled coils
    protein design
    protein evolution
    protein structure
    transmembrane signal tranduction
  25. Andreas Martin

    University of California, Berkeley, United States

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    AAA+ ATPases
    protein degradation
    proteostasis
    ATPase mechanism
    protein folding
  26. Elizabeth A Miller

    MRC Laboratory of Molecular Biology, United Kingdom

    Expertise
    Cell Biology
    Biochemistry and Chemical Biology
    Research focus
    membrane traffic
    endoplasmic reticulum
    protein quality control
    COPII vesicles
    Experimental organism
    S. cerevisiae
  27. Noboru Mizushima

    University of Tokyo, Japan

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Research focus
    protein degradation
    lysosome
    autophagy
    protein/organelle degradation
    autophagosome
    Experimental organism
    mouse
    yeast
  28. Hitoshi Nakatogawa

    Tokyo Institute of Technology, Japan

    Expertise
    Cell Biology
    Biochemistry and Chemical Biology
    Research focus
    molecular mechanisms of autophagy
    protein/organelle degradation
    membrane dynamics
    Experimental organism
    S. cerevisiae
  29. Geeta Narlikar

    University of California, San Francisco, United States

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    chromatin
    heterochromatin spread
    chromatin remodeling machines
  30. Hannes Neuweiler

    University of Würzburg, Germany

    Expertise
    Structural Biology and Molecular Biophysics
    Biochemistry and Chemical Biology
    Research focus
    protein dynamics
    protein folding
    protein engineering
    fluorescence spectroscopy
    fluorescence probe development
    single-molecule fluorescence spectroscopy
    kinetics
    Experimental organism
    E. coli
  31. Timothy Nilsen

    Case Western Reserve University, United States

    Expertise
    Biochemistry and Chemical Biology
    Chromosomes and Gene Expression
    Research focus
    mRNA processing
    mechanism of miRNA function
    RNA protein interactions
    mRNP composition and function
    RNA biology
    Experimental organism
    D. melanogaster
  32. Kim Orth

    University of Texas Southwestern Medical Center, United States

    Expertise
    Biochemistry and Chemical Biology
    Microbiology and Infectious Disease
    Research focus
    bacterial pathogenesis
    Type III secretion
    host-pathogen interactions
    signaling
    AMPylation
    Experimental organism
    Vibrio spp
    E. coli
    human
    S. cerevisiae
  33. Jon Pines

    Institute of Cancer Research, University College London, United Kingdom

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Research focus
    cyclins and anaphase promoting complex/cycosome (APC/C)
    cell cycle
    mitosis
    spindle assembly checkpoint
    Experimental organism
    human
  34. Arun Radhakrishnan

    University of Texas Southwestern Medical Center, United States

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Structural Biology and Molecular Biophysics
    Research focus
    lipid sensors
    cholesterol
    sphingomyelin
    cholesterol transport
    SREBP
    Scap
    cholesterol homeostasis
    endoplasmic reticulum
    Experimental organism
    E. coli
    human
    mouse
  35. Michael Rape

    University of California, Berkeley, United States

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Research focus
    stem cells
    ubiquitin
    ubiquitylation
    degradation
    proteasome
    E3 ligase
    p97/VCP
    differentiation
    quality control
    Experimental organism
    human
    mouse
    Xenopus
  36. Tricia Serio

    The University of Massachusetts, Amherst, United States

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Research focus
    prion
    protein misfolding
    chaperones
    amyloid
    Experimental organism
    S. cerevisiae
  37. Nima Sharifi

    Cleveland Clinic, United States

    Expertise
    Biochemistry and Chemical Biology
    Cancer Biology
    Research focus
    steroid biochemistry
    steroid metabolism
    prostate cancer
    nuclear receptors
    hormone therapy resistance
    androgens
    oncology
    Experimental organism
    mouse
  38. Wesley Sundquist

    University of Utah School of Medicine, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Microbiology and Infectious Disease
    Biochemistry and Chemical Biology
    Research focus
    virus assembly
    HIV
    ESCRT
    abscission
    innate immunity
  39. Wilfred van der Donk

    University of Illinois at Urbana-Champaign, United States

    Expertise
    Biochemistry and Chemical Biology
    Research focus
    antibiotics
    enzymology
    biosynthesis
    phosphonates
    peptides
    bacteria
    Experimental organism
    E. coli
  40. Oliver Weichenrieder

    Max Planck Institute for Developmental Biology, Germany

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Genetics and Genomics
    Research focus
    retrotransposition
    regulatory mRNA
    x-ray crystallography
    structural biology
  41. William I Weis

    Stanford University, United States

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    cell adhesion
    wnt signaling
    x-ray crystallography
    structural biology
    Experimental organism
    C. elegans
    Dictyostelium
    human
    mouse
  42. Mingjie Zhang

    Hong Kong University of Science and Technology, Hong Kong SAR China

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    postsynaptic density
    synaptic signaling
    scaffold proteins
    liquid-liquid phase separation
    biological condensates