Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Subtle selectivity in a pheromone sensor triumvirate desynchronizes competence and predation in a human gut commensal

   Johann Mignolet et al.

   A new cell–cell communication system in Streptococcus salivarius, a human gut commensal, discriminates between close signaling molecules to specifically produce bacteriocin-based antimicrobials and disconnects it from foreign DNA acquisition.
2. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   A conserved Mcm4 motif is required for Mcm2-7 double-hexamer formation and origin DNA unwinding

   Kanokwan Champasa et al.

   Analysis of an essential motif in Mcm4 provides insights into replicative helicase double-hexamer formation and the first step requiring this intermediate during replication initiation.
3. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   A potent voltage-gated calcium channel inhibitor engineered from a nanobody targeted to auxiliary Ca_Vβ subunits

   Travis J Morgenstern et al.

   A novel engineered protein that uncouples electrical signals from downstream biological responses in excitable cells provides a unique investigative tool with potential therapeutic applications.
4. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   Profiling the Escherichia coli membrane protein interactome captured in Peptidisc libraries

   Michael Luke Carlson et al.

   Trapping of the cell envelope proteome into water-soluble peptidisc library allows high-throughput definition of the membrane protein interactome.
5. 1. Biochemistry and Chemical Biology
   2. Human Biology and Medicine

   Repression of ferritin light chain translation by human eIF3

   Mia C Pulos-Holmes et al.
6. 1. Biochemistry and Chemical Biology
   2. Immunology and Inflammation

   PHLPP1 counter-regulates STAT1-mediated inflammatory signaling

   Ksenya Cohen Katsenelson et al.

   Uncovering a mechanism for how inflammatory signaling is opposed by a phosphatase identifies a potential druggable target to treat E. coli sepsis.
7. 1. Biochemistry and Chemical Biology
   2. Evolutionary Biology

   Cell Signaling: Learning from ancestors

   Suk ho Hong, Neel H Shah

   Applying ancestral sequence reconstruction techniques to protein kinases reveals the mutations that underlie different modes of activation.
8. 1. Biochemistry and Chemical Biology
   2. Evolutionary Biology

   Ancestral reconstruction reveals mechanisms of ERK regulatory evolution

   Dajun Sang et al.

   Tight regulation of a central developmental kinase cascade evolved through two key mutations.
9. 1. Biochemistry and Chemical Biology
   2. Genetics and Genomics

   A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis

   Ritu Gupta et al.

   The role of an amino acid-dependent tRNA modification as a nutrient sensor and regulator of metabolic homeostasis has been discovered.
10. 1. Biochemistry and Chemical Biology

    Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a

    Gavin J Knott et al.