Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway

   Nicholas Chim et al.

   Insight into the mechanism of DNA synthesis is provided by the crystal structures of DNA polymerase intermediates.
2. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling

   Phi Luong et al.

   Inflammatory bowel disease risk-gene, INAVA and the ARF-GEF ARNO, regulates non-canonical cortical actin assembly and IL-1b signaling to maintain epithelial homeostasis.
3. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Tuning site-specific dynamics to drive allosteric activation in a pneumococcal zinc uptake regulator

   Daiana A Capdevila et al.

   Internal dynamics play a crucial functional role in MarR (multiple antibiotic resistance repressor) proteins and their role reconciles the distinct allosteric mechanisms proposed previously.
4. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development

   Joel Hrit et al.

   The epigenetic regulator TET1 is regulated by the nutrient-sensing enzyme OGT in vitro and in cells.
5. 1. Biochemistry and Chemical Biology
   2. Immunology and Inflammation

   The allosteric activation of cGAS underpins its dynamic signaling landscape

   Richard M Hooy, Jungsan Sohn

   Rigorous biophysical studies reconcile several conflicting views on how cGAS is activated, and present a new unifying allosteric activation mechanism.
6. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Consensus designs and thermal stability determinants of a human glutamate transporter

   Erica Cirri et al.

   A fast evolutionary approach to engineer membrane protein kinetic stability yields folded excitatory neurotransmitter transporters and provides insights into their denaturing pathway.
7. 1. Biochemistry and Chemical Biology
   2. Evolutionary Biology

   Functional trade-offs and environmental variation shaped ancient trajectories in the evolution of dim-light vision

   Gianni M Castiglione, Belinda SW Chang

   The evolution of the light-sensitive visual pigment rhodopsin involved functional tradeoffs that may have sacrificed rod photosensitivity for active-state protein stability to mitigate phototoxicity in tetrapods, but not in fishes.
8. 1. Biochemistry and Chemical Biology

   Affinity capture of polyribosomes followed by RNAseq (ACAPseq), a discovery platform for protein-protein interactions

   Xi Peng et al.

   Affinity capture of polyribosomes followed by RNAseq(ACAPSeq) is a technique that harnesses massively parallel sequencing to identify protein-protein interactions from any source from which polyribosomes can be purified.
9. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Peptidoglycan precursor synthesis along the sidewall of pole-growing mycobacteria

   Alam García-Heredia et al.

   Peptidoglycan precursor synthesis occurs in both growing and non-growing regions of the mycobacterial cell surface.
10. 1. Biochemistry and Chemical Biology
    2. Cancer Biology

    UBE2G1 governs the destruction of cereblon neomorphic substrates

    Gang Lu et al.

    Cereblon-based small-molecule degraders rely on the sequential action of ubiquitin-conjugating enzymes UBE2G1 and UBE2D3 to assemble K48-linked polyubiquitin chains on cereblon neomorphic substrates, resulting in their proteasomal degradation.