Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Ligand response of guanidine-IV riboswitch at single-molecule level

    Lingzhi Gao, Dian Chen, Yu Liu
    A folding-function model for the guanidine-IV riboswitch under both guanidine-free and guanidine-present conditions offers valuable insights into its regulatory mechanism.
    1. Biochemistry and Chemical Biology

    The membrane domains of mammalian adenylyl cyclases are lipid receptors

    Marius Landau, Sherif Elsabbagh ... Joachim E Schultz
    The dodecahelical membrane anchors of mammalian adenylyl cyclase isoforms are receptors for unsaturated free fatty acids and, as a tonic signal, enhance or attenuate GPCR/Gsα-stimulated cyclic AMP formation.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Determining the off-target activity of antibiotics and novel translation initiation sites in mitochondria

    James Marks, Emma Young, Markus Hafner
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production

    Parnian Arafi, Sujan Devkota ... Michael S Wolfe
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Recognition and Cleavage of Human tRNA Methyltransferase TRMT1 by the SARS-CoV-2 Main Protease

    Angel D’Oliviera, Xuhang Dai ... Jeffrey S Mugridge
    Revised
    Reviewed Preprint v2
    Updated
    1. Biochemistry and Chemical Biology
    2. Medicine

    Increased bone inflammation in type 2 diabetes and obesity correlates with Wnt signaling downregulation and reduced bone strength

    Giulia Leanza, Malak Faraj ... Nicola Napoli
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    Identification of Suitable Target/E3 Ligase Pairs for PROTAC Development using a Rapamycin-induced Proximity Assay (RiPA)

    Bikash Adhikari, Katharina Schneider ... Elmar Wolf
    Revised
    Reviewed Preprint v2
    Updated
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Control of 3ʹ splice site selection by the yeast splicing factor Fyv6

    Katherine A Senn, Karli A Lipinski ... Aaron A Hoskins
    Revised
    Reviewed Preprint v2
    Updated
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin

    Roman O Fedoryshchak, Karim El-Bouri ... Richard Treisman
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Biochemical and neurophysiological effects of deficiency of the mitochondrial import protein TIMM50

    Eyal Paz, Sahil Jain ... Abdussalam Azem
    Revised
    Reviewed Preprint v2
    Updated
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Highlights

    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

    Submit to our latest special issue in systems genetics

    1. Biochemistry and Chemical Biology

    A molecular dual carriageway

    William J Allen, Ian Collinson

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. David James
    University of Sydney, Australia
  3. Merritt Maduke
    Stanford University School of Medicine, United States
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