Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife publishes research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we publish and sign up for the latest research.
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Latest articles

    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation

    Morgane Boone et al.
    Genetically induced conformational modulation of eIF2B activates the Integrated Stress Response by impairing nucleotide exchange.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Structural, mechanistic, and physiological insights into phospholipase A-mediated membrane phospholipid degradation in Pseudomonas aeruginosa

    Florian Bleffert et al.
    Membrane homeostasis in bacteria relies on the controlled degradation of endogenous phospholipids by intracellular phospholipases A, however their structures and catalytic mechanism are still poorly understood.
    1. Biochemistry and Chemical Biology
    2. Epidemiology and Global Health

    Association of egg consumption, metabolic markers, and risk of cardiovascular diseases: A nested case-control study

    Lang Pan et al.
    The associations of egg consumption with metabolic markers and of these markers with cardiovascular disease (CVD) risk showed opposite directions, which may partially explain the protective effect of moderate egg consumption on CVD in the Chinese population.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Doublecortin engages the microtubule lattice through a cooperative binding mode involving its C-terminal domain

    Atefeh Rafiei et al.
    Doublecortin activates its C-terminal domain when its N-terminal domain engages the microtubule lattice, leading to self-associations that explain the stabilizing effect of Doublecortin in neuronal migration.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Respiro-Fermentation: To breathe or not to breathe?

    Lauren C Radlinski, Andreas J Bäumler
    Listeria monocytogenes uses respiration to sustain a risky fermentative lifestyle during infection.
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    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Role of oxidation of excitation-contraction coupling machinery in age-dependent loss of muscle function in Caenorhabditis elegans

    Haikel Dridi et al.
    The Ryanodine receptor type 1 calcium channels play a critical role in age-related muscle function loss.
    1. Biochemistry and Chemical Biology

    Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry

    Tiantian Wei et al.
    A potent and selective DYRK2 inhibitor has been developed and used as a chemical tool to reveal eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) and stromal interaction molecule 1 (STIM1) are new substrates for DYRK2.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Rate-limiting transport of positively charged arginine residues through the Sec-machinery is integral to the mechanism of protein secretion

    William J Allen et al.
    The time it takes to secrete a protein is dominated by diffusion of positively charged arginines through the channel across the membrane, but lysines avoid this problem as they are neutralised before transport.

Senior editors

  1. Anna Akhmanova
    Utrecht University, Netherlands
  2. Vivek Malhotra
    The Barcelona Institute of Science and Technology, Spain
  3. Kenton J Swartz
    National Institute of Neurological Disorders and Stroke, NIH, United States
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