Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology

   Towards a molecular mechanism underlying mitochondrial protein import through the TOM and TIM23 complexes

   Holly C Ford et al.

   Determination of a model of mitochondrial protein import elucidated using a high-resolution transport assay and kinetic modelling.
2. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Visualizing molecules of functional human profilin

   Morgan L Pimm et al.

   Fluorescently-tagged profilin-1 behaves similar to the tag-free protein in biochemical and cell-based assays.
3. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Conformational fingerprinting of allosteric modulators in metabotropic glutamate receptor 2

   Brandon Wey-Hung Liauw et al.
4. 1. Biochemistry and Chemical Biology

   A native chemical chaperone in the human eye lens

   Eugene Serebryany et al.

   The human eye lens imports and concentrates within itself a naturally abundant small molecule that inhibits cataract-associated aggregation of an eye lens protein before the aggregates get large enough to scatter light.
5. 1. Biochemistry and Chemical Biology

   Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function

   Makenna M Morck et al.

   Hypertrophic cardiomyopathy-causing mutations in the light chain-binding region of β-cardiac myosin's lever arm appear to disrupt myosin tail-based autoinhibition, while mutations in the pliant region of the lever arm reduce autoinhibition in the presence of actin and impact myosin’s powerstroke.
6. 1. Biochemistry and Chemical Biology

   DIP2 is a unique regulator of diacylglycerol lipid homeostasis in eukaryotes

   Sudipta Mondal et al.
7. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Antibacterial potency of Type VI amidase effector toxins is dependent on substrate topology and cellular context

   Atanas Radkov et al.
8. 1. Biochemistry and Chemical Biology

   Structure-based electron-confurcation mechanism of the Ldh-EtfAB complex

   Kanwal Kayastha et al.

   The cryo-EM structural and functional analyses reveals the lactate dehydrogenase/electron-transferring flavoprotein (Ldh-EtfAB) in its enzymatically active form and the geometry of the confurcating flow of two energetically spitted electrons via 2 FAD and 1 [4Fe-4S] cluster to a central FAD.
9. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   Integrating multi-omics data reveals function and therapeutic potential of deubiquitinating enzymes

   Laura M Doherty et al.

   The integration of experimental and data mining approaches provides novel insights into deubiquitinating enzymes individually and as a gene family.
10. 1. Biochemistry and Chemical Biology

    The orphan ligand, activin C, signals through activin receptor-like kinase 7

    Erich J Goebel et al.

    Activin class member, activin C, is a canonical TGFβ family member that signals through the type I receptor, action receptor-like kinase 7 and is resistant to follistatin antagonism.