Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Neuroscience

   Intramolecular domain dynamics regulate synaptic MAGUK protein interactions

   Nils Rademacher et al.
2. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM

   Valeria Kalienkova et al.

   cryo-EM reveals the properties of distinct conformations occupied during activation of the lipid scramblase nhTMEM16 and provides new insights into its interactions with the lipid environment.
3. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness

   Blake W Tye et al.
4. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Schnyder corneal dystrophy-associated UBIAD1 inhibits ER-associated degradation of HMG CoA reductase in mice

   Youngah Jo et al.

   UBIAD1 mediates a unique geranylgeranyl pyrophosphate-sensing mechanism that when disrupted, inhibits degradation of HMG CoA reductase and triggers overproduction of corneal cholesterol that characterizes the eye disease Schnyder Corneal Dystrophy.
5. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Regulating G protein-coupled receptors by topological inversion

   Bray Denard et al.

   Multiple biochemical assays show that the topology of CCR5 and possibly other GPCRs may be inverted by ceramide or other sphingolipids through the process of regulated alternative translocation.
6. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter

   Aaron T Bozzi et al.

   Nramp-family transporters adapt a common fold to a novel mechanism in which the spatial and temporal separation of like-charge transition metal and proton co-substrates circumvents the expected electrostatic repulsion.
7. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Functional instability allows access to DNA in longer Transcription Activator-Like Effector (TALE) arrays

   Kathryn Geiger-Schuller et al.
8. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Mechanisms of opening and closing of the bacterial replicative helicase

   Jillian Chase et al.

   Analysis of the Escherichia coli DnaB helicase•bacteriophage λ helicase loader (λP) complex provides insights into helicase opening, delivery to the origin and ssDNA entry, and closing in preparation for translocation.
9. 1. Biochemistry and Chemical Biology

   Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides

   Matthijs Kol et al.

   Photoswitchable ceramides containing an azobenzene photoswitch behave as light-controllable substrates for both sphingomyelin synthase and glucosylceramide synthase.
10. 1. Biochemistry and Chemical Biology
    2. Plant Biology

    Pyrophosphate modulates plant stress responses via SUMOylation

    M Görkem Patir-Nebioglu et al.

    In vivo inhibition of SUMO activating E1-enzymes by pyrophosphate reveals a mode of integrating metabolism and stress tolerance that is conserved across kingdoms.