Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Targeting mir128-3p alleviates myocardial insulin resistance and prevents ischemia-induced heart failure

   Andrea Ruiz-Velasco et al.

   Targeting mir128-3p could prevent cardiac insulin resistance in the non-infarcted myocardium and limit cardiac injury after myocardial infarction, delaying the development of heart failure.
2. 1. Biochemistry and Chemical Biology
   2. Immunology and Inflammation

   A loop structure allows TAPBPR to exert its dual function as MHC I chaperone and peptide editor

   Lina Sagert et al.

   A dedicated structural element facilitates chaperone and antigenic peptide selector function of TAP-associated glycoprotein, a major quality assurance auditor in adaptive immunity.
3. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment

   Xinru Wang et al.

   A novel dynamic charge-charge interaction between B56 and a subset of PP2A-B56 substrates is essential for substrate specificity, dephosphorylation and, for KIF4A, binding condensin I.
4. 1. Biochemistry and Chemical Biology

   Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function

   Susanne Gerndt et al.

   The lysosomal ion channel TPC2 emerges as an example of an ion channel in which ion selectivity is not fixed but rather agonist-selective.
5. 1. Chromosomes and Gene Expression
   2. Biochemistry and Chemical Biology

   Cooperative interactions facilitate stimulation of Rad51 by the Swi5-Sfr1 auxiliary factor complex

   Bilge Argunhan et al.

   The intrinsically disordered N-terminus of Sfr1 contains two Rad51 binding sites that facilitate Rad51 filament stabilization and ATPase stimulation by the Swi5-Sfr1 complex, leading to efficient Rad51-driven strand exchange.
6. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   The guide sRNA sequence determines the activity level of box C/D RNPs

   Andrea Graziadei et al.

   Integrative structural biology reveals a conformational equilibrium in the Box C/D methylation enzyme that regulates the extent of site-specific 2'-O-rRNA methylation in dependence of the RNA sequence.
7. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   An H3K9 methylation dependent protein interaction regulates the non-enzymatic function of a putative histone demethylase

   Gulzhan Raiymbek et al.
8. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   Structure-based discovery of potent and selective melatonin receptor agonists

   Nilkanth Patel et al.

   Large scale virtual screening using recently solved structures of Melatonin receptors yield discovery of 10 new high-affinity selective agonists, also revealing novel functional features, including biased signaling at Melatonin receptors.
9. 1. Biochemistry and Chemical Biology

   RNA-guided retargeting of Sleeping Beauty transposition in human cells

   Adrian Kovač et al.

   Fusion proteins composed of the Sleeping Beauty transposase and catalytically inactive Cas9 target transposon integration into genomic regions specified by single guide RNAs.
10. 1. Biochemistry and Chemical Biology

    Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding

    Julia R Kardon et al.

    The mitochondrial protein unfoldase ClpX activates the first enzyme in heme biosynthesis, ALAS, by targeted unfolding that gates access of cofactor to the ALAS active site.