Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite

    Abhinay Ramaprasad, Paul-Christian Burda ... Michael J Blackman
    The malaria parasite uses an enzyme called GDPD to absorb choline, an important nutrient, from the bloodstream and this is essential for the parasite to survive inside the red blood cell.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanism of Ca2+ transport by ferroportin

    Jiemin Shen, Azaan Saalim Wilbon ... Yaping Pan
    Cryo-EM structure and functional analyses show that human iron exporter ferroportin (Fpn) can bind and transport calcium ions and the transport activity is reduced when the concentration of ferrous ions is high.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Improved ANAP incorporation and VCF analysis reveal details of P2X7 current facilitation and a limited conformational interplay between ATP binding and the intracellular ballast domain

    Anna Durner, Ellis Durner, Annette Nicke
    Comparision of current and fluorescent kinetics from P2X7 receptor mutants labeled with the fluorescent amino acid ANAP suggests that the characteristic P2X7 current facilitation involves changes in channel gating rather than interactions or conformational changes of its intracellular ballast domain.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The conserved centrosomin motif, γTuNA, forms a dimer that directly activates microtubule nucleation by the γ-tubulin ring complex (γTuRC)

    Michael J Rale, Brianna Romer ... Sabine Petry
    An evolutionarily conserved protein sequence present in diverse species like yeast, frogs, chickens, and humans binds a well-known template for microtubule nucleation, the gamma-tubulin ring complex, activating and enhancing its ability to nucleate microtubules, even under low tubulin concentrations.
    1. Biochemistry and Chemical Biology

    Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase

    Hudson W Coates, Isabelle M Capell-Hattam ... Andrew J Brown
    Hypoxic accumulation of squalene, the substrate of squalene monooxygenase, triggers its proteasomal truncation to a constitutively active variant that preserves downstream sterol synthesis.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub

    Martin Wilkinson, Oliver J Wilkinson ... Mark S Dillingham
    New cryoEM structures reveal how small bacteriophage proteins suppress bacterial immunity.

Senior editors

  1. Richard Aldrich
    Richard Aldrich
    The University of Texas at Austin, United States
  2. Nancy Carrasco
    Vanderbilt University School of Medicine, United States
  3. Benoît Kornmann
    University of Oxford, United Kingdom
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