Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology

   Tandem riboswitches form a natural Boolean logic gate to control purine metabolism in bacteria

   Madeline E Sherlock et al.

   A riboswitch class has been discovered for phosphoribosyl pyrophosphate, the biochemical precursor of nucleotides, and this novel RNA sensor commonly operates in tandem with a guanine aptamer to function like a Boolean logic gate.
2. 1. Biochemistry and Chemical Biology

   Gene Regulation: Acting in tandem

   Robert A Battaglia, Ailong Ke

   RNA structures called tandem riboswitches allow bacteria to employ complex logical operations in response to nutrient starvation.
3. 1. Biochemistry and Chemical Biology

   Science Forum: Donated chemical probes for open science

   Susanne Müller et al.

   A collaboration between several pharmaceutical companies provides a unique resource of high-quality chemical probes and associated data from the companies to the academic community.
4. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Acyl chain asymmetry and polyunsaturation of brain phospholipids facilitate membrane vesiculation without leakage

   Marco M Manni et al.

   The asymmetric combination of saturated and polyunsaturated acyl chains in phospholipids as typically observed in synapses makes membranes prone to deformation and fission without compromising their impermeability.
5. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima

   Ekaterina Morgunova et al.

   The epistasis observed in TF-DNA binding preferences can be explained by the presence of two optima of very similar Gibbs energy that are located relatively far from each other in sequence space.
6. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling

   Yosuke Yoneyama et al.

   IRS-1, a canonical signaling mediator of IGF-I receptor, serves as an endocytic regulator of IGF-I receptor to facilitate the sustained IGF signaling.
7. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   ICE1 promotes the link between splicing and nonsense-mediated mRNA decay

   Thomas D Baird et al.

   A whole-genome siRNA screen identifies ICE1 as a factor required for accurate sensing and quality control of mRNAs containing premature stop codons.
8. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Multivalency of NDC80 in the outer kinetochore is essential to track shortening microtubules and generate forces

   Vladimir A Volkov et al.
9. 1. Biochemistry and Chemical Biology
   2. Immunology and Inflammation

   Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen

   Neel H Shah et al.

   A high-throughput comparison of substrate specificities of the Src-family kinases Lck and c-Src against a library of proteome-derived phosphorylation sites reveals that Lck has evolved divergent electrostatic features reflecting its involvement in T-cell signaling.
10. 1. Biochemistry and Chemical Biology
    2. Cell Biology

    Proteasome storage granules protect proteasomes from autophagic degradation upon carbon starvation

    Richard Scott Marshall, Richard David Vierstra