Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife publishes research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Maternal diet-induced obesity during pregnancy alters lipid supply to mouse E18.5 fetuses and changes the cardiac tissue lipidome in a sex-dependent manner

    Lucas C Pantale√£o et al.
    Maternal obesity alters the fetal cardiac and serum lipidome, promoting early fetal cardiac metabolic maturation, with evidence that the female heart lipidome is more responsive to an in utero obesogenic environment.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation

    Lindsay B Case et al.
    Biochemical and cell biological data suggest a model of nascent integrin adhesion complex formation based on synergistic phase separation of pathways surrounding the focal adhesion kinase (FAK) and the adaptor protein p130Cas.
    1. Biochemistry and Chemical Biology

    Native proline-rich motifs exploit sequence context to target actin-remodeling Ena/VASP protein ENAH

    Theresa Hwang et al.
    Short linear motifs throughout the intrinsically disordered proteome use sequence context in diverse ways to target actin remodeler ENAH.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites

    Noah M Dietzen et al.
    Docosahexaenoic acid (DHA) inhibits ELIC through state-dependent binding to a single site.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Generation and diversification of recombinant monoclonal antibodies

    Keith F DeLuca et al.
    Tools and methodologies to create and diversify recombinant antibodies and antibody fragments provide researchers with the ability to generate low-cost, high-yield immunological reagents.

Senior editors

  1. Philip Cole
    Harvard Medical School, United States
  2. David James
    University of Sydney, Australia
  3. Vivek Malhotra
    The Barcelona Institute of Science and Technology, Spain
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