Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology

    Structural rather than catalytic role for mitochondrial respiratory chain supercomplexes

    Michele Brischigliaro, Alfredo Cabrera-Orefice ... Erika Fernández-Vizarra
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The structural basis of the multi-step allosteric activation of Aurora B kinase

    Dario Segura-Peña, Oda Hovet ... Nikolina Sekulic
    An entropy switch controls the Aurora B autoactivation process through two distinct kinetic steps of phosphorylation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Drug Discovery: Decoding the mechanisms of allostery

    Saif Khan, Cornelius Gati
    A complex interplay between structure, conformational dynamics and pharmacology defines distant regulation of G protein-coupled receptors.
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    1. Biochemistry and Chemical Biology

    Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution

    Loïc Duffet, Elyse T Williams ... Tommaso Patriarchi
    A genetically encoded sensor and a photocaged peptide together enable precise investigation of human glucagon-like peptide-1 receptor activation with high spatiotemporal resolution.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    The RNA helicase DDX39B activates FOXP3 RNA splicing to control T regulatory cell fate

    Minato Hirano, Gaddiel Galarza-Muñoz ... Mariano A Garcia-Blanco
    RNA processing regulates gene expression of the key transcription factor FOXP3 in T regulatory cells impacting immune tolerance and susceptibility to autoimmune disease.

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Nancy Carrasco
    Vanderbilt University School of Medicine, United States
  3. Merritt Maduke
    Stanford University School of Medicine, United States
  4. See more editors