Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife publishes research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    N-chlorination mediates protective and immunomodulatory effects of oxidized human plasma proteins

    Agnes Ulfig et al.
    N-chlorination, a reversible, oxidative modification, turns plasma proteins into holdase-like chaperones, potent activators of immune cells and pro-survival factors for phagocytic immune cells.
    1. Biochemistry and Chemical Biology

    An explanation for origin unwinding in eukaryotes

    Lance D Langston, Michael E O'Donnell
    CMG helicase translocates with force while encircling duplex DNA, enabling two opposing CMG complexes at an origin to melt the duplex and switch to encircling separate single strands.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit

    Ching-Ju Tsai et al.
    The structure of a light-sensitive G protein-coupled receptor in complex with a Gi-protein heterotrimer provides a structural foundation for the role of the receptor C-terminal tail in scaffolding and signaling.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The autophagic membrane tether ATG2A transfers lipids between membranes

    Shintaro Maeda et al.
    The autophagy protein ATG2A tethers membranes and transfers lipids between them, suggesting that autophagosome membranes grow upon the acquisition of lipids from the ER through the ATG2A bridge.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural and mutational analysis of the ribosome-arresting human XBP1u

    Vivekanandan Shanmuganathan et al.
    Two integrated approaches shed light on how XBP1 arrest peptide induces intermediate level of translational pausing and identify hotspot positions to make it stronger.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A composition-dependent molecular clutch between T cell signaling condensates and actin

    Jonathon A Ditlev et al.
    Compositional changes alter actin binding by phase separated T cell signaling clusters, enabling cluster movement by distinct actin networks.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The C-terminal tail of the bacterial translocation ATPase SecA modulates its activity

    Mohammed Jamshad et al.
    The interaction of SecA with its substrate proteins is regulated by its evolutionarily conserved C-terminal tail, which autoinhibits SecA unless SecA binds to the ribosome.

Senior editors

  1. John Kuriyan
    John Kuriyan
    University of California, Berkeley, United States
  2. Vivek Malhotra
    The Barcelona Institute of Science and Technology, Spain
  3. Michael Marletta
    Michael Marletta
    University of California, Berkeley, United States
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