Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife publishes research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology

    Single molecule poly(A) tail-seq shows LARP4 opposes deadenylation throughout mRNA lifespan with most impact on short tails

    Sandy Mattijssen et al.
    LARP4 protects mRNAs against deadenylation over a wide range of poly(A) lengths but with most apparent functional impact on short lengths known to sensitize PABP binding and mRNA stability.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Transposase-assisted tagmentation of RNA/DNA hybrid duplexes

    Bo Lu et al.
    Tn5 transposase has direct tagmentation activity towards RNA/DNA hybrids, which is harnessed as a more convenient and faster RNA-seq library construction method and will benefit RNA and chromatin research.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Real-time in vivo imaging of extracellular ATP in the brain with a hybrid-type fluorescent sensor

    Nami Kitajima et al.
    Hybrid-type fluorescent ATP sensor showing submicromolar affinity, a large fluorescence response, high selectivity and pH-independence visualized extracellular ATP dynamics in the brain of living mice with high spatiotemporal resolution.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Antagonistic control of DDK binding to licensed replication origins by Mcm2 and Rad53

    Syafiq Abd Wahab, Dirk Remus
    The mechanism of Dbf4-dependent kinase (DDK) recruitment to replication origins and its regulation by the checkpoint have been identified.

Senior editors

  1. Philip Cole
    Harvard Medical School, United States
  2. José Faraldo-Gómez
    National Heart, Lung and Blood Institute, National Institutes of Health, United States
  3. David James
    University of Sydney, Australia
  4. See more editors