Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B

   Timo Vögtle et al.

   Heparan sulfates in the vessel wall bind and regulate signaling from the megakaryocyte/platelet-specific inhibitory receptor G6b-B, a critical regulator of platelet homeostasis.
2. 1. Biochemistry and Chemical Biology

   Oxygen Sensors: When is a target not a target?

   David C Bersten, Daniel J Peet

   Cells rely on prolyl hydroxylase enzymes to sense low levels of oxygen, but they might act on fewer targets than previously thought.
3. 1. Biochemistry and Chemical Biology

   Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

   Matthew E Cockman et al.

   Assays using recombinant HIF prolyl hydroxylases did not support hydroxylation of more than 20 reported non-HIF substrates under conditions where robust HIF hydroxylation was observed.
4. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Mitochondria supply ATP to the ER through a mechanism antagonized by cytosolic Ca²⁺

   Jing Yong et al.
5. 1. Biochemistry and Chemical Biology
   2. Plant Biology

   Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis

   Jinsheng Zhu et al.

   Genetic and biochemical analysis of two enzymes reveals that inositol pyrophosphate signaling molecules allow plants to sense and regulate cellular phosphate levels, and to take up more phosphate when needed.
6. 1. Biochemistry and Chemical Biology
   2. Human Biology and Medicine

   Repression of ferritin light chain translation by human eIF3

   Mia C Pulos-Holmes et al.

   Human ferritin light chain (FTL) mRNA translation is regulated via its 5'-untranslated region (5'-UTR) by three mechanisms: RNA folding, iron response protein binding, and eukaryotic translation initiation factor eIF3 binding.
7. 1. Biochemistry and Chemical Biology

   Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb

   Joshua E Mayfield et al.

   The phosphorylation of tyrosine in the heptad repeat of the C-terminal domain of the largest subunit of RNA polymerase II promotes Ser2 phosphorylation by P-TEFb for pausing release.
8. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Homology sensing via non-linear amplification of sequence dependent pausing by RecQ helicase

   Yeonee Seol et al.
9. 1. Biochemistry and Chemical Biology

   Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a

   Gavin J Knott et al.

   An ancestral helical bundle governs whether the crRNA-processing nuclease of CRISPR-Cas12a is exploited by a phage-encoded allosteric anti-CRISPR.
10. 1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice

    Yuyong Tao et al.

    Modular tetravalent antibodies can be engineered to stimulate signaling through any combination of Frizzled and LRP receptors to drive organoid growth and mobilize endogenous stem cells in vivo.