Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife publishes research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology

    A network of cytosolic (co)chaperones promotes the biogenesis of mitochondrial signal-anchored outer membrane proteins

    Layla Drwesh et al.
    An array of cytosolic co-chaperones and chaperones helps to maintain newly synthesized mitochondrial outer membrane proteins in an import competent state.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    DIP2 is a unique regulator of diacylglycerol lipid homeostasis in eukaryotes

    Sudipta Mondal et al.
    DIP2 is a conserved protein across fungi and animals that regulates specific diacylglycerol pools by diverting them to storage lipid biosynthesis to enable cellular homeostasis and adaptations.
    1. Biochemistry and Chemical Biology
    2. Ecology

    Green fluorescent protein-like pigments optimise the internal light environment in symbiotic reef-building corals

    Elena Bollati et al.
    Scalar irradiance microsensor measurements performed inside the tissue of living corals show that absorption and fluorescence emission by host pigments produce dramatic spectral alterations in the light environment experienced by the symbionts.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    µ-Theraphotoxin Pn3a inhibition of CaV3.3 channels reveals a novel isoform-selective drug binding site

    Jeffrey R McArthur et al.
    The spider venom peptide Pn3a recognizes a pharmacophore unique to CaV3.3 amongst T-type calcium channels, underscoring its potential as a novel molecular tool for the study of CaV3.3-mediated currents in native cells.
    1. Biochemistry and Chemical Biology
    2. Medicine

    Structure-activity relationships of mitochondria-targeted tetrapeptide pharmacological compounds

    Wayne Mitchell et al.
    Sequence-variant analogs of mitochondria-targeted tetrapeptides have distinct patterns of membrane-bound conformations, effects on membrane properties, and abilities to protect mitochondria subject to stress, illuminating how side chain variation can be leveraged in the development of more effective therapeutic compounds.

Senior editors

  1. Richard Aldrich
    Richard Aldrich
    The University of Texas at Austin, United States
  2. Amy H Andreotti
    Iowa State University, United States
  3. Nancy Carrasco
    Vanderbilt University School of Medicine, United States
  4. See more editors