Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife publishes research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology

    Task specialization across research careers

    Nicolas Robinson-Garcia et al.
    1. Biochemistry and Chemical Biology

    Gradual compaction of the nascent peptide during cotranslational folding on the ribosome

    Marija Liutkute et al.
    HemK NTD cotranslational folding starts within the ribosome exit tunnel upon N-terminal helix synthesis and proceeds sequentially through a series of intermediates becoming less dynamic as the nascent chain grows.
    1. Cell Biology
    2. Biochemistry and Chemical Biology

    Feedback control of Wnt signaling based on ultrastable histidine cluster co-aggregation between Naked/NKD and Axin

    Melissa V Gammons et al.
    An unusual molecular mechanism has been revealed based on ultrastable histidine cluster co-aggregation underlying feedback control of an ancient cell communication pathway.
    1. Biochemistry and Chemical Biology

    A novel DNA primase-helicase pair encoded by SCCmec elements

    Aleksandra Bebel et al.
    SCCmec genomic islands encode a novel primase-helicase pair in which priming ability is conferred upon an A-family DNA polymerase domain by a novel protein cofactor.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Light-regulated allosteric switch enables temporal and subcellular control of enzyme activity

    Mark Shaaya et al.
    Light-sensitive allosteric switch module, a broadly applicable protein engineering method, is used for the regulation of protein activity with tight temporal control and spatial precision.

Senior editors

  1. José Faraldo-Gómez
    National Heart, Lung and Blood Institute, National Institutes of Health, United States
  2. David James
    University of Sydney, Australia
  3. Vivek Malhotra
    The Barcelona Institute of Science and Technology, Spain
  4. See more editors