Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology

    Genome-wide synthetic-lethality screen of Bam complex associated genes in Escherichia coli

    Jack A Bryant, Kara A Staunton ... Manuel Banzhaf
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Determining the off-target activity of antibiotics and novel translation initiation sites in mitochondria

    James Marks, Emma Young, Markus Hafner
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Squidly harnesses enzyme functional hierarchy and contrastive learning to efficiently predict catalytic residues from sequence

    William JF Rieger, Mikael Bodén ... Ariane Mora
    Squidly enables efficient identification of enzyme catalytic residues by integrating functional hierarchies into a contrastive learning framework, requiring only protein sequences to produce scalable predictions across the known enzyme landscape.
    1. Biochemistry and Chemical Biology

    A Membrane-Disruptive Action of VBIT-4 Challenges Its Role as a Widely Used VDAC1 Oligomerization Inhibitor

    Varun Ravishankar, Luís Borges-Araújo ... Lucie Bergdoll
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Physics of Living Systems

    Microscopic PhotoSelection (MiPS) of single cells in mother machine microfluidic devices

    Jessica James, Idris Kempf ... Harrison Steel
    Not revised
    Reviewed Preprint v1
    • Useful
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Ecology

    Planetary-scale heterotrophic microbial community modeling assesses metabolic synergy and viral impacts

    Antoine Régimbeau, Funing Tian ... Damien Eveillard
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology

    Integrated Respirometry and Metabolomics Unveil Circadian Metabolic Dynamics in Drosophila

    Farheen Akhtar, Dania Malik ... Aalim M Weljie
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology

    A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins

    Daniel J Kelpsch, Liyun Zhang ... Steven A Farber
    An in vivo small-molecule drug screen in developing zebrafish larvae identifies dozens of unique chemical modulators capable of reducing atherogenic apolipoprotein B levels.
    1. Biochemistry and Chemical Biology

    Cell cycle-coupled CK1δ turnover, autoinhibition, and activity

    Fidel E Serrano, Bianca Ruppert ... Michael Brunner
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Macrodomain catalytic activity modulates Chikungunya virus dissemination and transmission potential in Aedes mosquitoes

    Eugenia S Bardossy, Lena Bergmann ... Maria-Carla Saleh
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
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Highlights

    1. Biochemistry and Chemical Biology

    Lipid Transport: How membranes shape up for lipid transfer

    Takashi Hirashima, Toshiya Endo
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Metabolism: How one nutrient controls cell size

    Angela Montero, Lydia WS Finley
    1. Biochemistry and Chemical Biology

    RNA: Searching for druggable targets

    Lana Heganovic, Luiz FM Passalacqua

Senior editors

  1. Qiang Cui
    Boston University, United States
  2. Volker Dötsch
    Goethe University, Germany
  3. Kenton J Swartz
    National Institute of Neurological Disorders and Stroke, NIH, United States
  4. See more editors