Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Immunology and Inflammation

   N-chlorination mediates protective and immunomodulatory effects of oxidized human plasma proteins

   Agnes Ulfig et al.

   N-chlorination, a reversible, oxidative modification, turns plasma proteins into holdase-like chaperones, potent activators of immune cells and pro-survival factors for phagocytic immune cells.
2. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide

   Dominik Witzigmann et al.
3. 1. Biochemistry and Chemical Biology

   An explanation for origin unwinding in eukaryotes

   Lance D Langston, Michael E O'Donnell

   CMG helicase translocates with force while encircling duplex DNA, enabling two opposing CMG complexes at an origin to melt the duplex and switch to encircling separate single strands.
4. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Electroporated recombinant proteins as tools for in vivo functional complementation, imaging, and chemical biology

   Amal Alex et al.
5. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit

   Ching-Ju Tsai et al.

   The structure of a light-sensitive G protein-coupled receptor in complex with a Gi-protein heterotrimer provides a structural foundation for the role of the receptor C-terminal tail in scaffolding and signaling.
6. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   The autophagic membrane tether ATG2A transfers lipids between membranes

   Shintaro Maeda et al.

   The autophagy protein ATG2A tethers membranes and transfers lipids between them, suggesting that autophagosome membranes grow upon the acquisition of lipids from the ER through the ATG2A bridge.
7. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Structural and mutational analysis of the ribosome-arresting human XBP1u

   Vivekanandan Shanmuganathan et al.

   Two integrated approaches shed light on how XBP1 arrest peptide induces intermediate level of translational pausing and identify hotspot positions to make it stronger.
8. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   A composition-dependent molecular clutch between T cell signaling condensates and actin

   Jonathon A Ditlev et al.

   Compositional changes alter actin binding by phase separated T cell signaling clusters, enabling cluster movement by distinct actin networks.
9. 1. Biochemistry and Chemical Biology
   2. Plant Biology

   Flavodiiron proteins 1-to-4 function in versatile combinations in O₂ photoreduction in cyanobacteria

   Anita Isabel Santana Sanchez et al.
10. 1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The C-terminal tail of the bacterial translocation ATPase SecA modulates its activity

    Mohammed Jamshad et al.

    The interaction of SecA with its substrate proteins is regulated by its evolutionarily conserved C-terminal tail, which autoinhibits SecA unless SecA binds to the ribosome.