Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Cryo-EM structure of the adenosine A_2A receptor coupled to an engineered heterotrimeric G protein

   Javier García-Nafría et al.

   The adenosine A2a receptor couples to the heterotrimeric G protein Gs using both conserved contacts seen in other complexes and, in addition, novel contacts to the beta subunit of the G protein.
2. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria

   Minxian Qian et al.

   The ATM-SIRT6 axis integrates the DNA repair machinery to longevity-promoting pathways.
3. 1. Biochemistry and Chemical Biology

   Ribozyme-catalysed RNA synthesis using triplet building blocks

   James Attwater et al.
4. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Proteasome storage granules protect proteasomes from autophagic degradation upon carbon starvation

   Richard S Marshall, Richard D Vierstra

   Proteasomes are protected from autophagic elimination upon carbon starvation by sequestration into cytoplasmic storage granules, which aid cell fitness by providing a cache of proteasomes that can be rapidly remobilized when carbon availability improves.
5. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing-bisphosphonates

   Zhou Yu et al.
6. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   The universally-conserved transcription factor RfaH is recruited to a hairpin structure of the non-template DNA strand

   Philipp Konrad Zuber et al.
7. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Multivalency of NDC80 in the outer kinetochore is essential to track shortening microtubules and generate forces

   Vladimir A Volkov et al.

   Multiple NDC80 complexes in the outer kinetochore cooperate to bind the ends of depolymerizing microtubules and harness their power stroke.
8. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Topoisomerase VI senses and exploits both DNA crossings and bends to facilitate strand passage

   Timothy J Wendorff, James M Berger

   The engagement of DNA crossings is shown to license ATP hydrolysis and DNA cleavage by topoisomerase VI, a finding with mechanistic ramifications for related GHKL ATPases and meiotic recombination machineries.
9. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   A robust and tunable mitotic oscillator in artificial cells

   Ye Guan et al.

   The development of a robust and tunable artificial cell-cycle system paves the way for quantitative characterization of complex clock functions.
10. 1. Biochemistry and Chemical Biology

    Tandem riboswitches form a natural Boolean logic gate to control purine metabolism in bacteria

    Madeline E Sherlock et al.

    A riboswitch class has been discovered for phosphoribosyl pyrophosphate, the biochemical precursor of nucleotides, and this novel RNA sensor commonly operates in tandem with a guanine aptamer to function like a Boolean logic gate.