Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology

    Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein

    Yasuhiro Shinkai, Yunjie Ding ... Yoshito Kumagai
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Modular DNA Barcoding of Nanobodies Enables Multiplexed in situ Protein Imaging and High-throughput Biomolecule Detection

    Shilin Zhong, Ruiyu Wang ... Minmin Luo
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin

    Roman O Fedoryshchak, Karim El-Bouri ... Richard Treisman
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    The alternative oxidase reconfigures the larval mitochondrial electron transport system to accelerate growth and development in Drosophila melanogaster

    Geovana S Garcia, Murilo F Othonicar ... Marcos T Oliveira
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Biochemistry and Chemical Biology

    Epitope Sequence and Modification Fingerprints of Anti-Aβ Antibodies

    Ivan Talucci, Timon Leske ... Hans-Michael Maric
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology

    Targeted Protein Degradation by KLHDC2 Ligands Identified by High Throughput Screening

    Han Zhou, Tongliang Zhou ... Michael J Bollong
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology

    Blue-shifted ancyromonad channelrhodopsins for multiplex optogenetics

    Elena G Govorunova, Oleg A Sineshchekov ... John L Spudich
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Identification and classification of ion-channels across the tree of life: Insights into understudied CALHM channels

    Rahil Taujale, Sung Jin Park ... Natarajan Kannan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    • Inadequate
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Shifting the PPARγ conformational ensemble towards a transcriptionally repressive state improves covalent inhibitor efficacy

    Liudmyla Arifova, Brian S MacTavish ... Douglas J Kojetin
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Biochemistry and Chemical Biology

    Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response

    CJ San Felipe, Jyoti Batra ... James S Fraser
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
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Highlights

    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

    Submit to our latest special issue in systems genetics

    1. Biochemistry and Chemical Biology

    A molecular dual carriageway

    William J Allen, Ian Collinson

Senior editors

  1. Qiang Cui
    Boston University, United States
  2. Pankaj Kapahi
    Buck Institute for Research on Aging, United States
  3. Dominique Soldati-Favre
    University of Geneva, Switzerland
  4. See more editors