Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets

   Palur V Raghuvamsi et al.

   SARS-CoV-2 spike protein binding to receptor angiotensin-converting enzyme 2 allosterically enhances furin proteolysis at distal S1/S2 cleavage sites.
2. 1. Biochemistry and Chemical Biology
   2. Neuroscience

   Phasic oxygen dynamics confounds fast choline-sensitive biosensor signals in the brain of behaving rodents

   Ricardo M Santos, Anton Sirota

   Fast fluctuations of oxygen, linked to behavioral and neural dynamics in vivo, cause phasic transients is amperometry-measured cholinergic signals via the mechanism of non-steady-state enzyme kinetics in the choline-oxidase-based biosensor.
3. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Disease related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors

   Manoj K Rathinaswamy et al.
4. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   HP1 proteins compact DNA into mechanically and positionally stable phase separated domains

   Madeline M Keenen et al.

   Heterochromatin proteins compartmentalize DNA into compact structures resistant to mechanical disruption but susceptible to competitive dissolution.
5. 1. Biochemistry and Chemical Biology
   2. Evolutionary Biology

   Mitochondrial copper and phosphate transporter specificity was defined early in the evolution of eukaryotes

   Xinyu Zhu et al.

   Ancient evolutionary signatures reveal mechanistic details of substrate specificity in copper-transporting mitochondria carrier family proteins.
6. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein

   Xiangrong Chen et al.

   Discovery and characterisation of a novel allosteric inhibitor-binding site in human Bloom syndrome protein.
7. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics

   Haibin Yang et al.

   Structural, biochemical, and cell biology study revealed that Rsu1, through binding to PINCH1, inhibits the actin bundling ability of ILK/PINCH/Parvin to regulate the actin dynamics at focal adhesion.
8. 1. Biochemistry and Chemical Biology

   Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

   Rajendra Uprety et al.

   The structure-based design established a new approach to control pathway-selective activation of opioid receptors, resulting in new dual MOR/KOR G-protein biased agonist analgesics with attenuated liabilities.
9. 1. Biochemistry and Chemical Biology

   Identification of host proteins differentially associated with HIV-1 RNA splice variants

   Rachel Knoener et al.

   The distinct protein-RNA interactomes of HIV-1 RNA splice forms are revealed using a powerful multiplex strategy for RNA capture and mass spectrometric analysis.
10. 1. Biochemistry and Chemical Biology

    Real time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin binding proteins

    Victor M Hernández-Rocamora et al.