Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy

   Hidehiko Okuma, Jeffrey M Hord ... Kevin P Campbell
2. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite

   Abhinay Ramaprasad, Paul-Christian Burda ... Michael J Blackman

   The malaria parasite uses an enzyme called GDPD to absorb choline, an important nutrient, from the bloodstream and this is essential for the parasite to survive inside the red blood cell.
3. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Mechanism of Ca²⁺ transport by ferroportin

   Jiemin Shen, Azaan Saalim Wilbon ... Yaping Pan

   Cryo-EM structure and functional analyses show that human iron exporter ferroportin (Fpn) can bind and transport calcium ions and the transport activity is reduced when the concentration of ferrous ions is high.
4. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Principles of RNA recruitment to viral ribonucleoprotein condensates in a segmented dsRNA virus

   Sebastian Strauss, Julia Acker ... Ralf Jungmann
5. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Improved ANAP incorporation and VCF analysis reveal details of P2X7 current facilitation and a limited conformational interplay between ATP binding and the intracellular ballast domain

   Anna Durner, Ellis Durner, Annette Nicke

   Comparision of current and fluorescent kinetics from P2X7 receptor mutants labeled with the fluorescent amino acid ANAP suggests that the characteristic P2X7 current facilitation involves changes in channel gating rather than interactions or conformational changes of its intracellular ballast domain.
6. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   The conserved centrosomin motif, γTuNA, forms a dimer that directly activates microtubule nucleation by the γ-tubulin ring complex (γTuRC)

   Michael J Rale, Brianna Romer ... Sabine Petry

   An evolutionarily conserved protein sequence present in diverse species like yeast, frogs, chickens, and humans binds a well-known template for microtubule nucleation, the gamma-tubulin ring complex, activating and enhancing its ability to nucleate microtubules, even under low tubulin concentrations.
7. 1. Biochemistry and Chemical Biology

   Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase

   Hudson W Coates, Isabelle M Capell-Hattam ... Andrew J Brown

   Hypoxic accumulation of squalene, the substrate of squalene monooxygenase, triggers its proteasomal truncation to a constitutively active variant that preserves downstream sterol synthesis.
8. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   RNA sequence to structure analysis from comprehensive pairwise mutagenesis of multiple self-cleaving ribozymes

   Jessica M Roberts, James D Beck ... Eric J Hayden
9. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Targeting RNA:protein interactions with an integrative approach leads to the identification of potent YBX1 inhibitors

   Krystel El Hage, Nicolas Babault ... David Pastré
10. 1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub

    Martin Wilkinson, Oliver J Wilkinson ... Mark S Dillingham

    New cryoEM structures reveal how small bacteriophage proteins suppress bacterial immunity.