Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   UBE2G1 governs the destruction of cereblon neomorphic substrates

   Gang Lu et al.
2. 1. Biochemistry and Chemical Biology

   Poly(ADP-ribose) polymerase 1 searches DNA via a ‘monkey bar’ mechanism

   Johannes Rudolph et al.

   By moving between DNA segments like a child swinging on monkey bars, poly(ADP-ribose) polymerase 1 explores possible DNA damage sites more effectively.
3. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Insights into the key determinants of membrane protein topology enable the identification of new monotopic folds

   Sonya Entova et al.

   Key sequence motifs, defined using the first reported structure of a monotopic membrane protein with a reentrant helix, enable identification of new monotopic membrane protein families previously predicted as membrane spanning.
4. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Tracing a protein's folding pathway over evolutionary time using ancestral sequence reconstruction and hydrogen exchange

   Shion An Lim et al.
5. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Peptidoglycan precursor synthesis along the sidewall of pole-growing mycobacteria

   Alam García-Heredia et al.
6. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   Defective RNA polymerase III is negatively regulated by the SUMO-Ubiquitin-Cdc48 pathway

   Zheng Wang et al.

   The SUMO-Ub-Cdc48 pathway is a novel regulatory mechanism of Pol III and a potential therapeutic target for Pol III-related human diseases.
7. 1. Biochemistry and Chemical Biology
   2. Evolutionary Biology

   Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin

   Angela M Phillips et al.
8. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   Coevolution-based inference of amino acid interactions underlying protein function

   Victor H Salinas, Rama Ranganathan

   A deep mutational coupling study demonstrates the ability of sequence coevolution methods to reveal the pattern of amino acid interactions underlying protein function.
9. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Structures reveal opening of the store-operated calcium channel Orai

   Xiaowei Hou et al.
10. 1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    VivosX, a disulfide crosslinking method to capture site-specific, protein-protein interactions in yeast and human cells

    Chitra Mohan et al.

    An in vivo disulfide crosslinking assay shows preferential disassembly of nucleosomes with two H2A.Z histones by transcription machinery in yeast and conjugation to one or two ubiquitin moieties in human cells.