Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Structure-based inhibitors of amyloid beta core suggest a common interface with tau

   Sarah L Griner et al.

   Aβ inhibitors effectively block its aggregation, while also reducing seeding of tau aggregation from Aβ, tau, and AD derived fibrils, suggesting the two share a structurally related disease relevant interface.
2. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1

   Brian G Peterson et al.
3. 1. Biochemistry and Chemical Biology

   Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy

   Benjamin G Horst et al.

   The full-length structures of the mammalian nitric oxide receptor reveal the molecular activation steps and a binding site for the prototype of FDA-approved stimulators.
4. 1. Biochemistry and Chemical Biology

   Non-enzymatic primer extension with strand displacement

   Lijun Zhou et al.
5. 1. Biochemistry and Chemical Biology

   Enzyme Mechanisms: Wedging open a catalytic site

   Annie Beuve

   The activation mechanism of the nitric oxide receptor has been revealed by cryo-electron microscopy.
6. 1. Biochemistry and Chemical Biology

   Amidst multiple binding orientations on fork DNA, Saccharolobus MCM helicase proceeds N-first for unwinding

   Himasha M Perera, Michael A Trakselis

   The archaeal MCM helicase can load in multiple orientations on DNA but translocation proceeds with a leading N-terminal domain, which affects double hexamer activation at origins of replication.
7. 1. Biochemistry and Chemical Biology
   2. Neuroscience

   Cyclin dependent kinase 5 (CDK5) regulates the circadian clock

   Andrea Brenna et al.
8. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Near-infrared dual bioluminescence imaging in mouse models of cancer using infraluciferin

   Cassandra L Stowe et al.

   Two cellular populations can be tracked in the same small animal model using near-infrared bioluminescence imaging, for the first time opening up the window for multi-coloured bioluminescence.
9. 1. Biochemistry and Chemical Biology

   PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

   Kerryn Berndsen et al.
10. 1. Biochemistry and Chemical Biology
    2. Cell Biology

    The lysosomal transporter MFSD1 is essential for liver homeostasis and critically depends on its accessory subunit GLMP

    David Massa López et al.

    The so far uncharacterized lysosomal transporter protein MFSD1 is essential for liver homeostasis and needs the highly glycosylated GLMP protein as an accessory subunit for stability.