Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology

   RNA: Searching for druggable targets

   Lana Heganovic, Luiz FM Passalacqua

   A strategy that analyzes the structural properties of RNA could help identify regions that are promising targets for antiviral drugs.
2. 1. Biochemistry and Chemical Biology
   2. Developmental Biology

   Human eIF2A has a minimal role in translation initiation and in uORF-mediated translational control in HeLa cells

   Mykola Roiuk, Marilena Neff, Aurelio A Teleman

   Although eIF2A is thought to be a translation initiation factor, loss of eIF2A has no effect on cellular mRNA translation in either unstressed or stressed conditions.
3. 1. Biochemistry and Chemical Biology

   Exploiting functional regions in the viral RNA genome as druggable entities

   Dehua Luo, Yingge Zheng ... Dengguo Wei

   SHAPE-MaP reveals functional RNA structures in the porcine epidemic diarrhea virus genome, enabling targeted siRNA design and offering a promising strategy to inhibit viral replication.
4. 1. Biochemistry and Chemical Biology

   Engineering NIR-Sighted Bacteria

   Stefanie SM Meier, Michael Hörzing ... Andreas Möglich
5. 1. Biochemistry and Chemical Biology

   Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediate

   Prateeka Borar, Tapan Biswas ... Smarajit Polley

   Autocatalytic dual specificity of kinase IKK2/β, a Serine/Threonine kinase, is important for its substrate phosphorylation activity through an uncommon phosphorelay mechanism.
6. 1. Biochemistry and Chemical Biology
   2. Genetics and Genomics

   Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice

   Laura Sophie Kremer, Guanbin Gao ... Nils-Göran Larsson

   Regulation of mitochondrial DNA copy number is highly tissue-specific and context-dependent, particularly in the presence of disease.
7. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

   Sarah M Chang, Muhammad Bin Munim ... Matthew G Vander Heiden
8. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Coral anthozoan-specific opsins employ a novel chloride counterion for spectral tuning

   Yusuke Sakai, Saumik Sen ... Akihisa Terakita
9. 1. Biochemistry and Chemical Biology

   Differential Regulation of Hepatic Macrophage Fate by Chi3l1 in MASLD

   Jia He, Bo Chen ... Zhao Shan
10. 1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin

    Roman O Fedoryshchak, Karim El-Bouri ... Richard Treisman

    Proteomics with PP1-Neurabin fusion proteins identify the 4E-BP proteins as novel Neurabin/PP1 substrates, and interaction with the Neurabin PDZ domain shown to be the major determinant of Neurabin/PP1 substrate specificity.