Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology

   Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload

   Maria Carmela Filomena et al.
2. 1. Biochemistry and Chemical Biology

   Witnessing the structural evolution of an RNA enzyme

   Xavier Portillo et al.

   An RNA enzyme is caught in the act of evolving a new structural domain within its active site, resulting in enhanced catalytic function.
3. 1. Biochemistry and Chemical Biology

   A universal pocket in fatty acyl-AMP ligases ensures redirection of fatty acid pool away from coenzyme A-based activation

   Gajanan S Patil et al.

   The structural basis of how an enzyme differentiates chemically identical molecules unlike its homolog to channel fatty acids towards secondary metabolism is elucidated.
4. 1. Biochemistry and Chemical Biology

   Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins

   Urszula Nowicka et al.

   Defective mitochondrial protein import results in protein aggregation and a specific chaperone response in the cytosol, causatively linking mitochondrial function and cellular protein homeostasis disturbances observed in neurodegeneration.
5. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Endothelial pannexin 1–TRPV4 channel signaling lowers pulmonary arterial pressure in mice

   Zdravka Daneva et al.

   Endothelial pannexin 1-P2Y2 purinergic receptor-TRPV4 channel signaling, facilitated by caveolin-1, is a novel pathway for lowering pulmonary arterial pressure.
6. 1. Biochemistry and Chemical Biology
   2. Neuroscience

   Precise optical control of gene expression in C elegans using improved genetic code expansion and Cre recombinase

   Lloyd Davis et al.

   A method combining optimised genetic code expansion and optogenetics allows dissection of neural circuits with single-cell precision in freely moving animals.
7. 1. Biochemistry and Chemical Biology
   2. Genetics and Genomics

   Drosophila STING protein has a role in lipid metabolism

   Katarina Akhmetova et al.

   Drosophila STING protein, or stimulator of interferon genes, has a direct but previously unknown role in the lipid metabolism.
8. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   An essential, kinetoplastid-specific GDP-Fuc: β-D-Gal α-1,2-fucosyltransferase is located in the mitochondrion of Trypanosoma brucei

   Giulia Bandini et al.

   The activity, localization, and essentiality of TbFUT1, together with its ability to complement Leishmania parasites lacking the homologous gene, suggest the presence of an uncommon and conserved mitochondrial fucosylation pathway required for kinetoplastid parasites viability.
9. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace

   Maren Heimhalt et al.

   The inhibitory protein DEPTOR make two widely separated interactions with mTOR that are both necessary for its unique partial mTOR inhibition, and DEPTOR is a more potent inhibitor of mutation- or RHEB-activated mTORC1 than basal mTORC1.
10. 1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Addressing shortfalls of laboratory HbA_1c using a model that incorporates red cell lifespan

    Yongjin Xu et al.

    The person-specific adjusted HbA_1c addresses non-glycaemic variation in laboratory HbA_1c due to red blood cell lifespan differences, potentially providing a better marker to predict diabetes complications and guide glycaemic management.