Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia

   Margaret A M Nelson et al.
2. 1. Biochemistry and Chemical Biology

   Dwarf open reading frame (DWORF) is a direct activator of the sarcoplasmic reticulum calcium pump SERCA

   M'Lynn E Fisher et al.

   Activation of the sarcoplasmic reticulum calcium pump and enhancement of cellular calcium homeostasis by dwarf open reading frame reveal how this small membrane protein opposes phospholamban inhibitory function in cardiac muscle.
3. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   A subcellular map of the human kinome

   Haitao Zhang et al.

   An immunofluorescent analysis of 465 protein kinases revealed a substantial role of liquid-liquid phase separation in kinase localization and identified new kinase localizations to mitochondria and other organelles.
4. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Translation inhibitory elements from Hoxa3 and Hoxa11 mRNAs use uORFs for translation inhibition

   Fatima Alghoul et al.

   Hoxa3 and Hoxa11 translation inhibitory elements block cap-dependent translation by using upstream open reading frames with distinct modes of action.
5. 1. Biochemistry and Chemical Biology
   2. Immunology and Inflammation

   In vitro proteasome processing of neo-splicetopes does not predict their presentation in vivo

   Gerald Willimsky et al.

   Analysis of neo-splicetope-specific T cell responses strongly questions the idea that in vitro proteasome-catalyzed peptide splicing reaction simulates the in vivo situation with the same high fidelity as the in vitro generation of non-spliced epitopes.
6. 1. Biochemistry and Chemical Biology
   2. Immunology and Inflammation

   Cancer: Beware the algorithm

   Peter van Endert

   Spliced peptides present on tumor cells can help to mount an immune response, but algorithms offer limited help in predicting which ones actually exist and perform this role in vivo.
7. 1. Biochemistry and Chemical Biology

   The molecular coupling between substrate recognition and ATP turnover in a AAA+ hexameric helicase loader

   Neha Puri et al.
8. 1. Biochemistry and Chemical Biology

   Post-translational flavinylation is associated with diverse extracytosolic redox functionalities throughout bacterial life

   Raphaël Méheust et al.
9. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate

   Wan Hua Li et al.

   The first-in-class cell-permeant fluorescent probe provides direct and visual evidence of SARM1 activation in axonal degeneration and identified the first covalent, allosteric inhibitor of SARM1 acting on the NAD-binding pocket in the ARM domain.
10. 1. Biochemistry and Chemical Biology

    Sec17/Sec18 can support membrane fusion without help from completion of SNARE zippering

    Hongki Song et al.

    Sec18(NSF) and Sec17(αSNAP) provide a parallel pathway to fusion that is independent of energy from SNARE zippering.