Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology

   De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition

   Erich Stefan et al.

   By random nonstandard peptide integrated discovery, combinatorial macrocyclic peptides were leavaged that target a heterodimeric ABC transport complex and explore fundamental principles of the substrate translocation cycle.
2. 1. Biochemistry and Chemical Biology

   Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine

   Qiang Liu et al.

   Identifying and understanding that local anesthetic dyclonine targets TRPV3 channels will help to conceive therapeutic interventions.
3. 1. Biochemistry and Chemical Biology

   In vitro reconstitution reveals major differences between human and bacterial cytochrome c synthases

   Molly C Sutherland et al.

   Despite the known heme attachment motif (CXXCH) in all c-type cytochromes, attachment elements recognized by human and bacterial cytochrome c biogenesis pathways are distinct, providing clear targets for differential inhibitors.
4. 1. Biochemistry and Chemical Biology

   Protomer alignment modulates specificity of RNA substrate recognition by Ire1

   Weihan Li et al.

   Biochemical analysis and computational modeling reveal how cells mechanistically control the quality of their proteomes and demonstrate that the precise alignment of subunits in oligomeric complexes can profoundly affect enzymatic properties.
5. 1. Biochemistry and Chemical Biology

   Sec17/Sec18 can support membrane fusion without help from completion of SNARE zippering

   Hongki Song et al.
6. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate

   Wan Hua Li et al.
7. 1. Biochemistry and Chemical Biology

   OPA1 deletion in brown adipose tissue Improves thermoregulation and systemic metabolism via FGF21

   Renata O Pereira et al.
8. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Molecular insights into substrate recognition and discrimination by the N-terminal domain of Lon AAA+ protease

   Shiou-Ru Tzeng et al.

   The N-terminal domains enable Lon protease to discriminate and capture selected protein species for degradation by exposed hydrophobic patches and flexible linkages to the hexameric core complex.
9. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Transient kinetic studies of the antiviral Drosophila Dicer-2 reveal roles of ATP in self–nonself discrimination

   Raushan K Singh et al.

   A real-time, stopped-flow method, in combination with protein-induced fluorescence enhancement, Förster resonance energy transfer, and time-resolved fluorescence spectroscopy, reveals a kinetic framework for understanding Dicer as a complex molecular motor.
10. 1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    NusG is an intrinsic transcription termination factor that stimulates motility and coordinates gene expression with NusA

    Zachary F Mandell et al.

    The general transcription elongation factor NusG functions as an intrinsic termination factor in Bacillus subtilis and together with NusA coordinates global gene expression including the motility regulon.