Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A miniaturized MR1 metabolite display system with native-like protein features

    Photis Rotsides, Omkar Shinde ... Nikolaos G Sgourakis
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology

    Dynamic assembly of malate dehydrogenase-citrate synthase multienzyme complex in the mitochondria

    Joy Omini, Inga Krassovskaya ... Toshihiro Obata
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Effects of residue substitutions on the cellular abundance of proteins

    Thea K Schulze, Kresten Lindorff-Larsen
    Empirical substitution matrices from experimental measurements on 31,614 variants accurately predict cellular protein abundance changes using only amino-acid substitution and whether the site is buried or exposed.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

    Sarah M Chang, Muhammad Bin Munim ... Matthew G Vander Heiden
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Molidustat Targets a Synthetic Lethal Vulnerability in APC-Mutant Colorectal Cancer through GSTP1 and PHD2 Co-Inhibition

    Chiara Asselborn, Agata N Makar ... Alexander von Kriegsheim
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology

    Isolation of small extracellular vesicles from small volumes of blood plasma using size exclusion chromatography and density gradient ultracentrifugation

    Fang Kong, Megha Upadya ... Ming Dao
    The optimized protocol for isolating small extracellular vesicles from small blood volumes, confirmed by independent methods including cryo-electron microscopy, ensures superior purity and high yield for reliable biomarker detection.
    1. Biochemistry and Chemical Biology

    Single-step in vitro ribosome reconstitution mediated by two GTPase factors, EngA and ObgE

    Aya Sato, Weng Yu Lai ... Yoshihiro Shimizu
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    MORC2 mediates transcriptional regulation through liquid-liquid phase separation

    Yanshen Zhang, Weiya Xu ... Yihui Bi
    The dynamic internal fluidity of nuclear MORC2 condensates, rather than their mere assembly, is strictly required for transcriptional regulation and is selectively disrupted by neuropathy-linked mutations.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Experimental verification of the error minimization theory using non-standard genetic codes constructed in vitro

    Ryota Miyachi, Norikazu Ichihashi
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Biochemistry and Chemical Biology

    Metabolic compensation via gluconeogenesis explains the non-essentiality of glycogen phosphorylase as an insecticidal target in Plutella xylostella

    Yifei Zhou, Yanqi Kang ... Jiyuan Liu
    Not revised
    Reviewed Preprint v1
    • Inadequate
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Highlights

    1. Biochemistry and Chemical Biology

    Lipid Transport: How membranes shape up for lipid transfer

    Takashi Hirashima, Toshiya Endo
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Metabolism: How one nutrient controls cell size

    Angela Montero, Lydia WS Finley
    1. Biochemistry and Chemical Biology

    RNA: Searching for druggable targets

    Lana Heganovic, Luiz FM Passalacqua

Senior editors

  1. Volker Dötsch
    Goethe University, Germany
  2. Merritt Maduke
    Stanford University School of Medicine, United States
  3. Dominique Soldati-Favre
    University of Geneva, Switzerland
  4. See more editors