Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Neuroscience

   Alzheimer’s disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling

   Katarzyna Marta Zoltowska, Utpal Das ... Lucía Chávez-Gutiérrez

   A novel Aβ-driven inhibitory mechanism on γ-secretases, which leads to substrate accumulation and reduced release of products, contributes to neurotoxicity by impairing γ-secretase signaling and might operate in Alzheimer’s disease.
2. 1. Biochemistry and Chemical Biology
   2. Plant Biology

   Allosteric activation of the co-receptor BAK1 by the EFR receptor kinase initiates immune signaling

   Henning Mühlenbeck, Yuko Tsutsui ... Cyril Zipfel

   Structure-function analysis reveals an allosteric mechanism activating a plant immune receptor kinase complex.
3. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Hsp47 promotes biogenesis of multi-subunit neuroreceptors in the endoplasmic reticulum

   Ya-Juan Wang, Xiao-Jing Di ... Ting-Wei Mu

   Hsp47 positively regulates the functional surface expression of endogenous GABA_A receptors and plays a critical and general role in the maturation of Cys-loop neuroreceptors.
4. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug discovery

   Viviane Kremling, Sven Falke ... Janina Sprenger
5. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   Enrichment of rare codons at 5' ends of genes is a spandrel caused by evolutionary sequence turnover and does not improve translation

   Richard Sejour, Janet Leatherwood ... Bruce Futcher

   The 5' ends of genes are slightly enriched for rare codons largely because the ends turnover in evolution and gather rare codons, and these rare codons do not improve translation.
6. 1. Biochemistry and Chemical Biology

   The TTLL10 polyglycylase is stimulated by tubulin glutamylation and inhibited by polyglycylation

   Steven W Cummings, Yan Li ... Antonina Roll-Mecak
7. 1. Biochemistry and Chemical Biology

   Uncovering the BIN1-SH3 interactome underpinning centronuclear myopathy

   Boglarka Zambo, Evelina Edelweiss ... Gergo Gogl

   The SH3 domain of BIN1 mediates an unexpectedly large array of interactions, which is perturbed by missense variants.
8. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   Human DDX6 regulates translation and decay of inefficiently translated mRNAs

   Ramona Weber, Chung-Te Chang

   DDX6 triggers inefficiently translated mRNA decay by interacting with the ribosome through its FDF motif via the 5'-3' mRNA decay pathway.
9. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Two-way Dispatched function in Sonic hedgehog shedding and transfer to high-density lipoproteins

   Kristina Ehring, Sophia F Ehlers ... Kay Grobe
10. 1. Biochemistry and Chemical Biology

    A synthetic method to assay polycystin channel biophysics

    Megan Larmore, Orhi Esarte Palomero ... Paul G DeCaen