Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Molecular mechanisms of gating in the calcium-activated chloride channel bestrophin

   Alexandria N Miller et al.

   Cryo-EM structures of the gating cycle of bestrophin reveal the molecular underpinnings of activation and inactivation gating in this calcium-activated chloride channel and reveal a surprisingly wide pore.
2. 1. Biochemistry and Chemical Biology

   RNA-binding proteins distinguish between similar sequence motifs to promote targeted deadenylation by Ccr4-Not

   Michael W Webster et al.

   Biochemical reconstitution of deadenylation and analysis of binding kinetics reveals how RNA-binding proteins select their mRNA targets.
3. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Synergy between RecBCD subunits is essential for efficient DNA unwinding

   Rani Zananiri et al.

   A new optical tweezers assay sheds light on the mechanism of cooperation and force generation by the subunits of RecBCD, critical for the repair of double strand breaks in bacteria.
4. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   The elemental mechanism of transcriptional pausing

   Jason Saba et al.

   Biochemical analyses of transcription complexes, including kinetic studies and probes of translocational and conformational states, establish the elemental mechanism of pausing, which underlies regulation of gene expression in all organisms.
5. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Crystal structure of a natural light-gated anion channelrhodopsin

   Hai Li et al.

   The atomic structure of GtACR1 provides new insight into the chemical mechanism of natural light-gated anion membrane conductance, and enables its optimization for optogenetic photoinhibition of neuron firing.
6. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   ATP-induced asymmetric pre-protein folding as a driver of protein translocation through the Sec machinery

   Robin A Corey et al.

   How the process of protein folding may be controlled by the Sec machinery to assist protein transport across membranes.
7. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Pat1 promotes processing body assembly by enhancing the phase separation of the DEAD-box ATPase Dhh1 and RNA

   Ruchika Sachdev et al.
8. 1. Biochemistry and Chemical Biology

   Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease

   Silvia C Bobeica et al.
9. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex

   Charles B Phillips et al.
10. 1. Biochemistry and Chemical Biology
    2. Neuroscience

    eIF2B activator prevents neurological defects caused by a chronic integrated stress response

    Yao Liang Wong et al.

    Boosting the function of translation factor eIF2B by chronic small molecule administration prevents pathology in a neurodegenerative model of Vanishing White Matter disease characterized by a maladaptive stress response.