Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Synthetic single domain antibodies for the conformational trapping of membrane proteins

   Iwan Zimmermann et al.

   Synthetic single domain antibody libraries and a binder selection cascade encompassing ribosome and phage display enable the selection of conformation-specific binders against previously intractable membrane proteins within three weeks.
2. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Novel transgenic pigs with enhanced growth and reduced environmental impact

   Xianwei Zhang et al.

   Transgenic expression of glucanase, xylanase and phytase in pigs enhances growth performance and reduces nitrogen/phosphorus emission, and offers a very valuable biological strategy for sustainable resource utilization and environmental protection in the pork industry.
3. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Pollution: Transgenic pigs to the rescue

   Björn Petersen

   Genetically engineered pigs that digest their food better could help to reduce phosphorus and nitrogen pollution.
4. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Cryo-EM structure of the adenosine A_2A receptor coupled to an engineered heterotrimeric G protein

   Javier García-Nafría et al.

   The adenosine A2a receptor couples to the heterotrimeric G protein Gs using both conserved contacts seen in other complexes and, in addition, novel contacts to the beta subunit of the G protein.
5. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria

   Minxian Qian et al.

   The ATM-SIRT6 axis integrates the DNA repair machinery to longevity-promoting pathways.
6. 1. Biochemistry and Chemical Biology

   Ribozyme-catalysed RNA synthesis using triplet building blocks

   James Attwater et al.
7. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Proteasome storage granules protect proteasomes from autophagic degradation upon carbon starvation

   Richard S Marshall, Richard D Vierstra

   Proteasomes are protected from autophagic elimination upon carbon starvation by sequestration into cytoplasmic storage granules, which aid cell fitness by providing a cache of proteasomes that can be rapidly remobilized when carbon availability improves.
8. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing-bisphosphonates

   Zhou Yu et al.
9. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   The universally-conserved transcription factor RfaH is recruited to a hairpin structure of the non-template DNA strand

   Philipp Konrad Zuber et al.
10. 1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Multivalency of NDC80 in the outer kinetochore is essential to track shortening microtubules and generate forces

    Vladimir A Volkov et al.

    Multiple NDC80 complexes in the outer kinetochore cooperate to bind the ends of depolymerizing microtubules and harness their power stroke.