Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology

   Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload

   Maria Carmela Filomena et al.

   Ablation of the sarcomeric protein myopalladin (MYPN), associated with human cardiomyopathies, results in dilated cardiomyopathy, which is severely aggravated by biomechanical stress, suggesting that skeletal myopathy patients carrying MYPN loss-of-function mutations may develop cardiomyopathy under conditions of cardiac stress.
2. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Short-chain fatty acids activate acetyltransferase p300

   Sydney P Thomas, John M Denu
3. 1. Biochemistry and Chemical Biology
   2. Genetics and Genomics

   5' modifications improve potency and efficacy of DNA donors for precision genome editing

   Krishna S Ghanta et al.
4. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   The inner mechanics of Rhodopsin Guanylyl Cyclase during cGMP-formation revealed by real-time FTIR spectroscopy

   Paul Fischer et al.
5. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   Competitive binding of MatP and topoisomerase IV to the MukB hinge domain

   Gemma LM Fisher et al.

   Topoisomerase IV and the ter-binding protein MatP competitively bind the hinge domain of the Escherichia coli Structural Maintenance of Chromosomes complex, MukB, leading to spatiotemporal regulation of MukBEF-topoisomerase IV activity.
6. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation

   Juan Carlos Rengifo-Gonzalez et al.

   The RNA-mediated higher order assembly of TDP-43, a protein associated with neurodegenerative diseases, preserves its solubility by reducing the risk of multivalent interactions between low complexity domains.
7. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy

   Vinay V Eapen et al.

   A combination of spatial proteomic and autophagic flux approaches was used to reveal the landscape of turnover of damaged lysosomes, demonstrating a key role for the autophagy receptor TAX1BP1 and its associated kinase TBK1 in both HeLa cells and iNeurons.
8. 1. Biochemistry and Chemical Biology
   2. Medicine

   Early prediction of in-hospital death of COVID-19 patients: a machine-learning model based on age, blood analyses, and chest x-ray score

   Emirena Garrafa et al.
9. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   PP2A/B55α substrate recruitment as defined by the retinoblastoma-related protein p107

   Holly Fowle et al.
10. 1. Biochemistry and Chemical Biology
    2. Ecology

    Fungi: Sex and self defense

    Milton T Drott

    The fungus Aspergillus nidulans produces secondary metabolites during sexual development to protect itself from predators.