Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Biochemistry and Chemical Biology

    Stabilization of GTSE1 by cyclin D1-CDK4/6-mediated phosphorylation promotes cell proliferation: relevance in cancer prognosis

    Nelson García-Vázquez, Tania J González-Robles ... Michele Pagano
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    AI-based discovery and cryoEM structural elucidation of a KATP channel pharmacochaperone

    Assmaa Elsheikh, Camden M Driggers ... Show-Ling Shyng
    Structure-based approach identifies a KATP-binding compound that has the potential of normalizing insulin secretion in congenital hyperinsulinism by correcting defective KATP channel trafficking to the cell surface.
    1. Biochemistry and Chemical Biology

    Induction of hepatitis B core protein aggregation targeting an unconventional binding site

    Vladimir Khayenko, Cihan Makbul ... Hans Michael Maric
    Targeting two novel sites on the hepatitis B virus capsid disrupts its assembly and induces aggregation, suggesting potential for antiviral therapy development.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Microphase separation produces interfacial environment within diblock biomolecular condensates

    Andrew P Latham, Longchen Zhu ... Bin Zhang
    The microenvironment within biomolecular condensates exhibits interfacial behaviors characterized by a combination of hydrophobic and hydrophilic properties.
    1. Biochemistry and Chemical Biology

    In silico screening by AlphaFold2 program revealed the potential binding partners of nuage-localizing proteins and piRNA-related proteins

    Kawaguchi Shinichi, Xu Xin ... Kai Toshie
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Biochemistry and Chemical Biology

    Crystal structure and catalytic mechanism of PL35 family glycosaminoglycan lyases with an ultrabroad substrate spectrum

    Lin Wei, Hai-Yan Cao ... Fuchuan Li
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Biochemistry and Chemical Biology

    Optogenetic control of Protein Kinase C-epsilon activity reveals its intrinsic signaling properties with spatiotemporal resolution

    Qunxiang Ong, Crystal Jing Yi Lim ... Weiping Han
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Kinetic regulation of kinesin’s two motor domains coordinates its stepping along microtubules

    Yamato Niitani, Kohei Matsuzaki ... Michio Tomishige
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing

    Jiale Zhou, Ding Zhao ... Zhanjun Li
    Revised
    Reviewed Preprint v4
    Updated
    • Useful
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Coral anthozoan-specific opsins employ a novel chloride counterion for spectral tuning

    Yusuke Sakai, Saumik Sen ... Akihisa Terakita
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
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Highlights

    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

    Submit to our latest special issue in systems genetics

    1. Biochemistry and Chemical Biology

    A molecular dual carriageway

    William J Allen, Ian Collinson

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Qiang Cui
    Boston University, United States
  3. Dominique Soldati-Favre
    University of Geneva, Switzerland
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