Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Developmental Biology

   Maternal diet-induced obesity during pregnancy alters lipid supply to mouse E18.5 fetuses and changes the cardiac tissue lipidome in a sex-dependent manner

   Lucas C Pantaleão et al.

   Maternal obesity alters the fetal cardiac and serum lipidome, promoting early fetal cardiac metabolic maturation, with evidence that the female heart lipidome is more responsive to an in utero obesogenic environment.
2. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   LRET-derived HADDOCK structural models describe the conformational heterogeneity required for DNA cleavage by the Mre11-Rad50 DNA damage repair complex

   Marella D Canny, Michael Latham
3. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation

   Lindsay B Case et al.

   Biochemical and cell biological data suggest a model of nascent integrin adhesion complex formation based on synergistic phase separation of pathways surrounding the focal adhesion kinase (FAK) and the adaptor protein p130Cas.
4. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Topoisomerase VI is a chirally-selective, preferential DNA decatenase

   Shannon J McKie et al.
5. 1. Biochemistry and Chemical Biology

   Native proline-rich motifs exploit sequence context to target actin-remodeling Ena/VASP protein ENAH

   Theresa Hwang et al.

   Short linear motifs throughout the intrinsically disordered proteome use sequence context in diverse ways to target actin remodeler ENAH.
6. 1. Biochemistry and Chemical Biology
   2. Genetics and Genomics

   Protein visualization and manipulation in Drosophila through the use of epitope tags recognized by nanobodies

   Jun Xu et al.
7. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites

   Noah M Dietzen et al.

   Docosahexaenoic acid (DHA) inhibits ELIC through state-dependent binding to a single site.
8. 1. Biochemistry and Chemical Biology
   2. Medicine

   RNA binding to human METTL3-METTL14 restricts N⁶-deoxyadenosine methylation of DNA in vitro

   Shan Qi et al.
9. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   Comprehensive interrogation of the ADAR2 deaminase domain for engineering enhanced RNA editing activity and specificity

   Dhruva Katrekar et al.
10. 1. Biochemistry and Chemical Biology
    2. Cell Biology

    Generation and diversification of recombinant monoclonal antibodies

    Keith F DeLuca et al.

    Tools and methodologies to create and diversify recombinant antibodies and antibody fragments provide researchers with the ability to generate low-cost, high-yield immunological reagents.