Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology

   Stabilization of GTSE1 by cyclin D1–CDK4/6-mediated phosphorylation promotes cell proliferation with implications for cancer prognosis

   Nelson García-Vázquez, Tania J González-Robles ... Michele Pagano

   Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.
2. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Teichoic acids in the periplasm and cell envelope of Streptococcus pneumoniae

   Mai Nguyen, Elda Bauda ... Cecile Morlot

   The thickness of the periplasmic region is reduced in strains of pneumococcus that are deleted in genes responsible for the incorporation of teichoic acid in the cell envelope.
3. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome

   Rohan Eapen, Cynthia Okoye ... Laura S Itzhaki
4. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   In silico screening by AlphaFold2 program revealed the potential binding partners of nuage-localizing proteins and piRNA-related proteins

   Shinichi Kawaguchi, Xin Xu ... Toshie Kai

   AlphaFold2-based large-scale screening reveals novel protein interactions, accelerating functional studies of piRNA pathway proteins and expanding bioinformatic-experimental integration.
5. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Kinetic regulation of kinesin’s two motor domains coordinates its stepping along microtubules

   Yamato Niitani, Kohei Matsuzaki ... Michio Tomishige

   Kinetic measurements of kinesin-1's front and rear heads reveal how different neck linker orientation regulate their activity, enabling the motor protein to move in a coordinated manner along microtubules.
6. 1. Biochemistry and Chemical Biology
   2. Genetics and Genomics

   Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice

   Laura S Kremer, Guanbin Gao ... Nils-Göran Larsson
7. 1. Biochemistry and Chemical Biology

   Phage-displayed synthetic library and screening platform for nanobody discovery

   Baolong Xia, Ah-Ram Kim ... Norbert Perrimon
8. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike

   A Sofia F Oliveira, Fiona L Kearns ... Adrian J Mulholland

   Equilibrium and nonequilibrium simulations uncover how the fatty acid site in the SARS-CoV-2 spike modulates protein dynamics, revealing its intricate allosteric connections and the impact of glycans on these networks.
9. 1. Biochemistry and Chemical Biology
   2. Genetics and Genomics

   High-resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery

   Conor J Howard, Nathan S Abell ... Nathan B Lubock

   Mapping the functional landscape of >6600 MC4R variants via deep mutational scanning reveals novel determinants of biased signaling and ligand interactions that inform targeted obesity therapeutics.
10. 1. Biochemistry and Chemical Biology

    Isolating Small Extracellular Vesicles from Small Volumes of Blood Plasma using size exclusion chromatography and density gradient ultracentrifugation: A Comparative Study

    Fang Kong, Megha Upadya ... Ming Dao