Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology

    Structural insights into heterohexameric assembly of epilepsy-related ligand–receptor complex LGI1–ADAM22

    Takayuki Yamaguchi, Kei Okatsu ... Shuya Fukai
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Coral anthozoan-specific opsins employ a novel chloride counterion for spectral tuning

    Yusuke Sakai, Saumik Sen ... Akihisa Terakita
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Elucidating the Mechanism Underlying UBA7•UBE2L6 Disulfide Complex Formation

    Pei-Tzu Chen, Jia-Yin Yeh ... Kuen-Phon Wu
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    AI-Based Discovery and CryoEM Structural Elucidation of a KATP Channel Pharmacochaperone

    Assmaa ElSheikh, Camden M Driggers ... Show-Ling Shyng
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike

    A Sofia F Oliveira, Fiona L Kearns ... Adrian J Mulholland
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology

    Action mechanism of a novel agrichemical quinofumelin against Fusarium graminearum

    Qian Xiu, Xiaoru Yin ... Yabing Duan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    In vivo exchange of glucose and lactate between photoreceptors and the retinal pigment epithelium

    Daniel T Hass, Elizabeth Giering ... James B Hurley
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response

    Pavla Nedbalova, Nikola Kaislerova ... Tomas Dolezal
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    On the role of VP3-PI3P interaction in birnavirus endosomal membrane targeting

    Flavia A Zanetti, Ignacio Fernandez ... Laura Ruth Delgui
    Molecular, biophysical, and computational analysis reveals insights on the mechanism of association of birnavirus VP3 with endosomes and its role in the viral life cycle, representing a substantial contribution toward understanding the replication strategy of these 'non-canonical' viruses.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Cellular Energy Production: Mycofactocin and the mycobacterial electron transport chain

    Stephanie M Stuteley, Ghader Bashiri
    In the bacterium M. smegmatis, an enzyme called MftG allows the cofactor mycofactocin to transfer electrons released during ethanol metabolism to the electron transport chain.
    Version of Record
    Insight
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Highlights

    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Electrons, bacteria and metabolism

    Stephanie M Stuteley, Ghader Bashiri
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    RNA knots and Alzheimer's disease

    Silvia Galli, Marco Di Antonio
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Qiang Cui
    Boston University, United States
  3. Merritt Maduke
    Stanford University School of Medicine, United States
  4. See more editors