Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife publishes research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Science Forum: Addressing selective reporting of experiments through predefined exclusion criteria

    Kleber Neves, Olavo B Amaral
    Researchers should define in advance the criteria for excluding the results of experiments that 'did not work' from articles.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A conserved and regulated mechanism drives endosomal Rab transition

    Lars Langemeyer et al.
    Reconstitution of the endosomal Rab cascade reveals that Rab5 binds and activates the Mon1-Ccz1 guanine nucleotide exchange factor, which in turn recruits Rab7 to membranes to drive fusion.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Lipid accumulation controls the balance between surface connection and scission of caveolae

    Madlen Hubert et al.
    Caveolae sense the membrane lipid composition, which influences their dynamic behavior at the cell surface.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I

    Zoe A Stephenson et al.
    1. Biochemistry and Chemical Biology

    A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking

    Katherine J Susa et al.
    The tetraspanin CD81 uses its ectodomain to export CD19, and the interaction of the two proteins is dynamically regulated by B cell activation state.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins

    Piyali Saha et al.
    Molecular analysis of cholesterol transport by NPC1 and NPC1L1 proteins reveals that cholesterol likely moves through these transporters, and ezetimibe blocks NPC1L1 by binding at the interface between multiple domains.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Reconstitution reveals two paths of force transmission through the kinetochore

    Grace Elizabeth Hamilton et al.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    An advanced cell cycle tag toolbox reveals principles underlying temporal control of structure-selective nucleases

    Julia Bittmann et al.
    The development of an advanced cell cycle tag toolbox will enable a wide variety of cell cycle studies and shows post-replicative function of nucleases resolving replication/recombination structures.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Heterogeneity of proteome dynamics between connective tissue phases of adult tendon

    Howard Choi et al.
    Metabolic labelling reveals complex proteome dynamics in tendon, with faster turnover of proteins in the glycoprotein-rich interfascicular matrix compared to the collagen-rich fascicular matrix.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation

    Ira Alexandra Iosub et al.
    High-throughput RNA-RNA interaction analysis uncovers many novel sRNA-target interactions at various growth stages in Escherichia coli.
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Senior editors

  1. Philip Cole
    Harvard Medical School, United States
  2. José Faraldo-Gómez
    National Heart, Lung and Blood Institute, National Institutes of Health, United States
  3. John Kuriyan
    John Kuriyan
    University of California, Berkeley, United States
  4. See more editors