Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology

    Uncovering the BIN1-SH3 interactome underpinning centronuclear myopathy

    Boglarka Zambo, Evelina Edelweiss ... Gergo Gogl
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Identification of a third myosin-5a-melanophilin interaction that mediates the association of myosin-5a with melanosomes

    Jiabin Pan, Rui Zhou ... Xiang-dong Li
    In addition to the exon-F-binding domain and the globular tail domain-binding motif, the actin-binding domain of melanophilin interacts with myosin-5a tail region and mediates the association of myosin-5a with melanosomes.
    1. Biochemistry and Chemical Biology

    Kinases in motion: impact of protein and small molecule interactions on kinase conformations

    Valentina Kugler, Selina Schwaighofer ... Eduard Stefan
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Heparan sulfate dependent phase separation of CCL5 and its chemotactic activity

    Xiaolin Yu, Guangfei Duan ... Shi-Zhong Luo
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase

    Roberto Efraín Díaz, Andrew K Ecker ... James S Fraser
    Biochemical and structural investigations of the pH adaptability of mouse Acidic Mammalian Chitinase offer insights for designing enhanced enzyme variants that can function in both lung and gut.