Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Multi-step recognition of potential 5' splice sites by the Saccharomyces cerevisiae U1 snRNP

   Sarah R Hansen et al.
2. 1. Biochemistry and Chemical Biology

   A network of cytosolic (co)chaperones promotes the biogenesis of mitochondrial signal-anchored outer membrane proteins

   Layla Drwesh et al.

   An array of cytosolic co-chaperones and chaperones helps to maintain newly synthesized mitochondrial outer membrane proteins in an import competent state.
3. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   An auto-inhibited state of protein kinase G and implications for selective activation

   Rajesh Sharma et al.
4. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition

   Yitong Li et al.
5. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase

   Ryo Fujisawa et al.
6. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   DIP2 is a unique regulator of diacylglycerol lipid homeostasis in eukaryotes

   Sudipta Mondal et al.

   DIP2 is a conserved protein across fungi and animals that regulates specific diacylglycerol pools by diverting them to storage lipid biosynthesis to enable cellular homeostasis and adaptations.
7. 1. Biochemistry and Chemical Biology
   2. Ecology

   Green fluorescent protein-like pigments optimise the internal light environment in symbiotic reef-building corals

   Elena Bollati et al.

   Scalar irradiance microsensor measurements performed inside the tissue of living corals show that absorption and fluorescence emission by host pigments produce dramatic spectral alterations in the light environment experienced by the symbionts.
8. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   µ-Theraphotoxin Pn3a inhibition of Ca_V3.3 channels reveals a novel isoform-selective drug binding site

   Jeffrey R McArthur et al.

   The spider venom peptide Pn3a recognizes a pharmacophore unique to Ca_V3.3 amongst T-type calcium channels, underscoring its potential as a novel molecular tool for the study of Ca_V3.3-mediated currents in native cells.
9. 1. Biochemistry and Chemical Biology
   2. Medicine

   Structure-activity relationships of mitochondria-targeted tetrapeptide pharmacological compounds

   Wayne Mitchell et al.

   Sequence-variant analogs of mitochondria-targeted tetrapeptides have distinct patterns of membrane-bound conformations, effects on membrane properties, and abilities to protect mitochondria subject to stress, illuminating how side chain variation can be leveraged in the development of more effective therapeutic compounds.
10. 1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Selenocyanate derived Se-incorporation into the Nitrogenase Fe protein cluster

    Trixia M Buscagan et al.