Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice

    Laura Sophie Kremer, Guanbin Gao ... Nils-Göran Larsson
    Regulation of mitochondrial DNA copy number is highly tissue-specific and context-dependent, particularly in the presence of disease.
    1. Biochemistry and Chemical Biology

    Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediate

    Prateeka Borar, Tapan Biswas ... Smarajit Polley
    Autocatalytic dual specificity of kinase IKK2/β, a Serine/Threonine kinase, is important for its substrate phosphorylation activity through an uncommon phosphorelay mechanism.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

    Sarah M Chang, Muhammad Bin Munim ... Matthew G Vander Heiden
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Coral anthozoan-specific opsins employ a novel chloride counterion for spectral tuning

    Yusuke Sakai, Saumik Sen ... Akihisa Terakita
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology

    Differential Regulation of Hepatic Macrophage Fate by Chi3l1 in MASLD

    Jia He, Bo Chen ... Zhao Shan
    Not revised
    Reviewed Preprint v1
    • Useful
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin

    Roman O Fedoryshchak, Karim El-Bouri ... Richard Treisman
    Proteomics with PP1-Neurabin fusion proteins identify the 4E-BP proteins as novel Neurabin/PP1 substrates, and interaction with the Neurabin PDZ domain shown to be the major determinant of Neurabin/PP1 substrate specificity.
    1. Biochemistry and Chemical Biology

    Phage-displayed synthetic library and screening platform for nanobody discovery

    Baolong Xia, Ah-Ram Kim ... Norbert Perrimon
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics

    Leonid Peshkin, Enrico Maria Daldello ... Catherine Jessus
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Polyphosphate Discriminates Protein Conformational Ensembles More Efficiently than DNA Promoting Diverse Assembly and Maturation Behaviors

    Saloni Goyal, Divya Rajendran ... Athi N Naganathan
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Human eIF2A has a minimal role in translation initiation and in uORF-mediated translational control in HeLa cells

    Mykola Roiuk, Marilena Neff, Aurelio A Teleman
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
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Highlights

    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

    Submit to our latest special issue in systems genetics

    1. Biochemistry and Chemical Biology

    A molecular dual carriageway

    William J Allen, Ian Collinson

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Qiang Cui
    Boston University, United States
  3. Volker Dötsch
    Goethe University, Germany
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