Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Endogenous oligomer formation underlies DVL2 condensates and promotes Wnt/β-catenin signaling

    Senem Ntourmas, Martin Sachs ... Dominic B Bernkopf
    1. Biochemistry and Chemical Biology

    Minimal twister sister (TS)-like self-cleaving ribozymes in the human genome revealed by deep mutational scanning

    Zhe Zhang, Xu Hong ... Jian Zhan
    1. Biochemistry and Chemical Biology

    A new class of receptors: Lipids regulate mammalian Gsα-stimulated adenylyl cyclase activities via their membrane anchors

    Marius Landau, Sherif Elsabbagh ... Joachim E Schultz
    1. Biochemistry and Chemical Biology

    The intrinsically disordered N-terminus of SUMO1 is an intramolecular inhibitor of SUMO1 interactions

    Sebastian M Richter, Fan Jin ... Frauke Melchior
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells

    Siying Zeng, Yuqi Wang ... Xun Hu
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    The deubiquitinase Ubp3/Usp10 constrains glucose-mediated mitochondrial repression via phosphate budgeting

    Vineeth Vengayil, Shreyas Niphadkar ... Sunil Laxman
    A primary constraint for mitochondrial repression is access to cytosolic inorganic phosphate, which is determined by the glycolytic flux rate.
    1. Biochemistry and Chemical Biology

    Disordered proteins interact with the chemical environment to tune their protective function during drying

    Shraddha KC, Kenny Nguyen ... Thomas C Boothby
    1. Biochemistry and Chemical Biology

    Stabilization of GTSE1 by cyclin D1-CDK4/6 promotes cell proliferation: relevance in cancer prognosis

    Nelson García-Vázquez, Tania J González-Robles ... Sharon Kaisari
    1. Biochemistry and Chemical Biology

    DTX3L ubiquitin ligase ubiquitinates single-stranded nucleic acids

    Emily L Dearlove, Chatrin Chatrin ... Danny T Huang
    1. Biochemistry and Chemical Biology

    Early Steps of Protein Disaggregation by Hsp70 Chaperone and Class B J-Domain Proteins are Shaped by Hsp110

    Wiktoria Sztangierska, Hubert Wyszkowski ... Agnieszka Kłosowska
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Highlights

    1. Biochemistry and Chemical Biology

    Improving immunotherapy

    Luca Unione, Jesús Jiménez-Barbero
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

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Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Qiang Cui
    Boston University, United States
  3. Dominique Soldati-Favre
    University of Geneva, Switzerland
  4. See more editors