Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology
    2. Cell Biology

    An engineered biosensor enables dynamic aspartate measurements in living cells

    Kristian Davidsen, Jonathan S Marvin ... Lucas B Sullivan
    A genetically encoded fluorescent biosensor reveals temporally resolved changes to aspartate concentration during genetic, pharmacological, and nutritional manipulations.
    1. Biochemistry and Chemical Biology

    Noncanonical usage of stop codons in ciliates expands proteins with structurally flexible Q-rich motifs

    Chi-Ning Chuang, Hou-Cheng Liu ... Ting-Fang Wang
    Noncanonical usage of stop codons in ciliates expands structurally flexible Q-rich domains and coevolves with codon usage biases to avoid triplet repeat disorders mediated by CAG/GTC replication slippage.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The catalytic mechanism of the RNA methyltransferase METTL3

    Ivan Corbeski, Pablo Andrés Vargas-Rosales ... Amedeo Caflisch
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    The differential regulation of placenta trophoblast bisphosphoglycerate mutase in fetal growth restriction: preclinical study in mice and observational histological study of human placenta

    Sima Stroganov, Talia Harris ... Michal Neeman
    Expression of Bisphosphoglycerate mutase, a key enzyme affecting the release of oxygen from hemoglobin, is augmented in the murine placenta challenged by gestational hypoxia in mice while its expression is attenuated in placenta of human FGR.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Remodelling of skeletal muscle myosin metabolic states in hibernating mammals

    Christopher T. A. Lewis, Elise G. Melhedegaard ... Julien Ochala
    1. Biochemistry and Chemical Biology

    Kinases in motion: impact of protein and small molecule interactions on kinase conformations

    Valentina Kugler, Selina Schwaighofer ... Eduard Stefan
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    β-catenin inhibition disrupts the homeostasis of osteogenic/adipogenic differentiation leading to the development of glucocorticoid-induced osteonecrosis of the femoral head

    Chenjie Xia, Huihui Xu ... Hongting Jin
    Deletion of β-catenin in Col2+ progenitor cells shifts their commitment from osteoblasts to adipocytes, leading to a full spectrum of disease phenotype of glucocorticoid-induced osteonecrosis of the femoral head in adult mice.