Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife publishes research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology

    Towards a molecular mechanism underlying mitochondrial protein import through the TOM and TIM23 complexes

    Holly C Ford et al.
    Determination of a model of mitochondrial protein import elucidated using a high-resolution transport assay and kinetic modelling.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Visualizing molecules of functional human profilin

    Morgan L Pimm et al.
    Fluorescently-tagged profilin-1 behaves similar to the tag-free protein in biochemical and cell-based assays.
    1. Biochemistry and Chemical Biology

    A native chemical chaperone in the human eye lens

    Eugene Serebryany et al.
    The human eye lens imports and concentrates within itself a naturally abundant small molecule that inhibits cataract-associated aggregation of an eye lens protein before the aggregates get large enough to scatter light.
    1. Biochemistry and Chemical Biology

    Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function

    Makenna M Morck et al.
    Hypertrophic cardiomyopathy-causing mutations in the light chain-binding region of β-cardiac myosin's lever arm appear to disrupt myosin tail-based autoinhibition, while mutations in the pliant region of the lever arm reduce autoinhibition in the presence of actin and impact myosin’s powerstroke.
    1. Biochemistry and Chemical Biology

    Structure-based electron-confurcation mechanism of the Ldh-EtfAB complex

    Kanwal Kayastha et al.
    The cryo-EM structural and functional analyses reveals the lactate dehydrogenase/electron-transferring flavoprotein (Ldh-EtfAB) in its enzymatically active form and the geometry of the confurcating flow of two energetically spitted electrons via 2 FAD and 1 [4Fe-4S] cluster to a central FAD.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Integrating multi-omics data reveals function and therapeutic potential of deubiquitinating enzymes

    Laura M Doherty et al.
    The integration of experimental and data mining approaches provides novel insights into deubiquitinating enzymes individually and as a gene family.
    1. Biochemistry and Chemical Biology

    The orphan ligand, activin C, signals through activin receptor-like kinase 7

    Erich J Goebel et al.
    Activin class member, activin C, is a canonical TGFβ family member that signals through the type I receptor, action receptor-like kinase 7 and is resistant to follistatin antagonism.

Senior editors

  1. Richard Aldrich
    Richard Aldrich
    The University of Texas at Austin, United States
  2. Nancy Carrasco
    Vanderbilt University School of Medicine, United States
  3. Dominique Soldati-Favre
    University of Geneva, Switzerland
  4. See more editors