Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology

   Inhibition of synucleinopathic seeding by rationally designed inhibitors

   Smriti Sangwan et al.

   Inhibitors of seeded propagation of alpha-synuclein may be developed into diagnostics and therapeutics for Parkinson's disease.
2. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways

   Spencer Hill et al.

   Human cullin-RING ligases are buffered to a much greater extent than had been previously appreciated, and the roles of ubiquitin chain extension enzymes are far more nuanced at physiological concentrations.
3. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   A polyomavirus peptide binds to the capsid VP1 pore and has potent antiviral activity against BK and JC polyomaviruses

   Joshua R Kane et al.

   A peptide derived from BK and JC polyomavirus protein VP2/3 inhibits viral infection by targeting a binding site in the pore of polyomavirus VP1 pentamers, enabling future VP1-targeted therapeutic strategies.
4. 1. Biochemistry and Chemical Biology

   HOPS recognizes each SNARE, assembling ternary trans-complexes for rapid fusion upon engagement with the 4th SNARE

   Hongki Song et al.
5. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   E. coli TraR allosterically regulates transcription initiation by altering RNA polymerase conformation

   James Chen et al.

   Cryo-electron microscopy structures, combined with biochemical experiments, show how the E. coli F element-encoded TraR protein regulates transcription initiation by altering RNA polymerase conformation and conformational heterogeneity.
6. 1. Biochemistry and Chemical Biology

   The human coronavirus HCoV-229E S-protein structure and receptor binding

   Zhijie Li et al.

   The HCoV-229E coronavirus S-protein accommodates extensive mutational change and possesses hydrophilic subunit interfaces in the S2 region, features that provide new insights into immune evasion, cross-species transmission and membrane fusion.
7. 1. Biochemistry and Chemical Biology

   The GTPase Nog1 co-ordinates the assembly, maturation and quality control of distant ribosomal functional centers

   Purnima Klingauf-Nerurkar et al.

   The GTPase Nog1 orchestrates stalk assembly, peptidyl transferase centre maturation and polypeptide exit tunnel quality control.
8. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   Perturbation of base excision repair sensitizes breast cancer cells to APOBEC3 deaminase-mediated mutations

   Birong Shen et al.

   Accumulation of mutations in some cancers is correlated with an aberration of DNA repair and access of a DNA deaminase to normal genomic DNA.
9. 1. Biochemistry and Chemical Biology
   2. Neuroscience

   A sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiency

   Tara L Mastro et al.
10. 1. Biochemistry and Chemical Biology
    2. Cell Biology

    Biochemical reconstitution of branching microtubule nucleation

    Raymundo Alfaro-Aco et al.

    The protein TPX2 and the protein complex augmin together recruit the microtubule nucleator γ-TuRC to a pre-existing microtubule where they initiate branching microtubule nucleation.