Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation

   Xiao-Tong Lin et al.

   Using IGF2BP1-PLK1 axis as an example, targeting oncogenic signaling represents a direction treatment for HCC patients with high FBXO45 expression.
2. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Type 1 polyisoprenoid diphosphate phosphatase modulates geranylgeranyl-mediated control of HMG CoA reductase and UBIAD1

   Rania Elsabrouty et al.

   Type 1 polyisoprenoid diphosphate phosphatase (PDP1) contributes to interconversion of isoprenols and isoprenylpyrophosphates, balancing the sterol and nonsterol branches of the mevalonate pathway by regulating ERAD of HMG CoA reductase and ER-to-Golgi transport of UBIAD1.
3. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation

   Jesse M Hansen et al.

   The yeast enzyme CTP synthase assembles inactive filaments that are driven to polymerization through the drop in cytoplasmic pH accompanying starvation.
4. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Molecular architecture of the human tRNA ligase complex

   Alena Kroupova et al.
5. 1. Biochemistry and Chemical Biology

   A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers

   Theresa Hwang et al.

   A peptide from PCARE achieves >100-fold binding specificity for the EVH1 domain of ENAH, a protein important for metastasis, using a conformational shift mechanism unavailable to ENAH's closely related paralogs VASP and EVL.
6. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Low affinity integrin states have faster ligand binding kinetics than the high affinity state

   Jing Li et al.
7. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions

   Aixin Song et al.

   Through interactions with both ubiquitin units that emanate from a branch point in polyubiquitin, UCH37 recognizes and hydrolyzes branched chains to promote proteasome-mediated degradation upon proteolytic stresses.
8. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Disentangling bias between G_q, GRK2, and arrestin3 recruitment to the M₃ muscarinic acetylcholine receptor

   Anja Floeser et al.

   Ligand-specific-induced conformations of M₃ muscarinic receptors reveal similar requirements for G protein-coupled receptor kinase 2 and G_q protein binding, whereas arrestin3 binding is mediated by distinct receptor conformations.
9. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   MCPH1 inhibits condensin II during interphase by regulating its SMC2-kleisin interface

   Martin Houlard et al.
10. 1. Biochemistry and Chemical Biology

    Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors

    Xiaozheng Xu et al.

    A molecular interpretation is provided for why some inhibitory immunoreceptors prefer to recruit SHP1 but others prefer SHP2.