Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Pleomorphic effects of three small-molecule inhibitors on transcription elongation by Mycobacterium tuberculosis RNA polymerase

    Omar Herrera-Asmat, Alexander B Tong ... Carlos Bustamante
    Optical tweezers are used to gain mechanistic insight in the mechanism of inhibition of three distinct compounds being developed as antibiotics against Mycobacterium tuberculosis.
    1. Biochemistry and Chemical Biology

    Brown adipose tissue and skeletal muscle coordinately contribute to thermogenesis in mice

    Yuna Izumi-Mishima, Rie Tsutsumi ... Hiroshi Sakaue
    Muscle-derived branched-chain amino acids support thermogenesis in brown adipose tissue, thereby helping maintain body temperature during impaired muscle function or physiological stress.
    1. Biochemistry and Chemical Biology

    Membrane mimetic thermal proteome profiling (MM-TPP) towards mapping membrane protein-ligand dynamic interactions

    Rupinder Singh Jandu, Ashim Bhattacharya ... Franck Duong van Hoa
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology

    General Trends in the Calnexin-Dependent Expression and Pharmacological Rescue of Clinical CFTR Variants

    Austin Tedman, John A Olson ... Jonathan P Schlebach
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    A recursive pathway for isoleucine biosynthesis arises from enzyme promiscuity

    Vittorio Rainaldi, Stefano Donati ... Nico J Claassens
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Biochemistry and Chemical Biology

    Engineering NIR-Sighted Bacteria

    Stefanie SM Meier, Michael Hörzing ... Andreas Möglich
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Dietary sulfur amino acid restriction elicits a cold-like transcriptional response in inguinal but not epididymal white adipose tissue of male mice

    Philip MM Ruppert, Aylin S Güller ... Jan-Wilhelm Kornfeld
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology

    Stall force measurement of the kinesin-3 motor KIF1A using a programmable DNA origami nanospring

    Nobumichi Takamatsu, Hiroko Furumoto ... Kumiko Hayashi
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology

    An aphid-resistant plant metabolite as a candidate aphicide: Insight into the bioactivity and action mode of betulin against aphids

    Junxiu Wang, Matthana Klakong ... Hong Zhou
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Squidly: Enzyme Catalytic Residue Prediction Harnessing a Biology-Informed Contrastive Learning Framework

    William JF Rieger, Mikael Boden ... Ariane Mora
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
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Highlights

    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

    Submit to our latest special issue in systems genetics

    1. Biochemistry and Chemical Biology

    A molecular dual carriageway

    William J Allen, Ian Collinson

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Merritt Maduke
    Stanford University School of Medicine, United States
  3. David Ron
    Cambridge University, United Kingdom
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