Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Role of BRCA2 DNA-binding and C-terminal domain in its mobility and conformation in DNA repair

   Maarten W Paul et al.

   Highly conserved C-terminal domains of the tumor suppressor BRCA2 are not essential for accumulation at damaged DNA but affect conformation and cell survival, implying roles beyond delivering strand-exchange protein RAD51.
2. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Genetically incorporated crosslinkers reveal NleE attenuates host autophagy dependent on PSMD10

   Jingxiang Li et al.

   Transient interactions between NleE and PMSD10 suppress PSMD10 interaction with ATG7 to attenuate host autophagosome formation.
3. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation

   Bence Hajdusits et al.
4. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53

   Liz Hernandez Borrero et al.

   Anti-tumor properties of sub-class of xanthine analogs involve restoration of p53 pathway transcriptome, independent of p53/p73, dependent on ATF3/ATF4 and Noxa in mutated-p53 tumors and the compounds trigger an S-phase checkpoint.
5. 1. Biochemistry and Chemical Biology

   Structure-guided microbial targeting of antistaphylococcal prodrugs

   Justin J Miller et al.

   Prodrug antibiotics can be designed that are serum-stable but readily cleaved inside bacterial pathogens.
6. 1. Biochemistry and Chemical Biology

   Tissue specific targeting of DNA nanodevices in a multicellular living organism

   Kasturi Chakraborty et al.
7. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Processing of the ribosomal ubiquitin-like fusion protein FUBI-eS30/FAU is required for 40S maturation and depends on USP36

   Jasmin van den Heuvel et al.
8. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   The fluoride permeation pathway and anion recognition in Fluc family fluoride channels

   Benjamin C McIlwain et al.

   In the extremely selective fluoride channels from the bacterial Fluc family, fluoride ions access the pore via two points, an electropositive vestibule and a triad of conserved residues involved in anion recognition.
9. 1. Biochemistry and Chemical Biology
   2. Plant Biology

   Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants

   Tatiana P Soares da Costa et al.
10. 1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    In vivo analysis reveals that ATP-hydrolysis couples remodeling to SWI/SNF release from chromatin

    Ben Tilly et al.