Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Kinetic regulation of kinesin’s two motor domains coordinates its stepping along microtubules

   Yamato Niitani, Kohei Matsuzaki ... Michio Tomishige

   Kinetic measurements of kinesin-1's front and rear heads reveal how different neck linker orientation regulate their activity, enabling the motor protein to move in a coordinated manner along microtubules.
2. 1. Biochemistry and Chemical Biology
   2. Genetics and Genomics

   Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice

   Laura S Kremer, Guanbin Gao ... Nils-Göran Larsson
3. 1. Biochemistry and Chemical Biology

   Phage-displayed synthetic library and screening platform for nanobody discovery

   Baolong Xia, Ah-Ram Kim ... Norbert Perrimon
4. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike

   A Sofia F Oliveira, Fiona L Kearns ... Adrian J Mulholland

   Equilibrium and nonequilibrium simulations uncover how the fatty acid site in the SARS-CoV-2 spike modulates protein dynamics, revealing its intricate allosteric connections and the impact of glycans on these networks.
5. 1. Biochemistry and Chemical Biology
   2. Genetics and Genomics

   High-resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery

   Conor J Howard, Nathan S Abell ... Nathan B Lubock

   Mapping the functional landscape of >6600 MC4R variants via deep mutational scanning reveals novel determinants of biased signaling and ligand interactions that inform targeted obesity therapeutics.
6. 1. Biochemistry and Chemical Biology

   Isolating Small Extracellular Vesicles from Small Volumes of Blood Plasma using size exclusion chromatography and density gradient ultracentrifugation: A Comparative Study

   Fang Kong, Megha Upadya ... Ming Dao
7. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Teichoic acids in the periplasm and cell envelope of Streptococcus pneumoniae

   Mai Nguyen, Elda Bauda ... Cecile Morlot
8. 1. Biochemistry and Chemical Biology

   Coordinated regulation of chemotaxis and resistance to copper by CsoR in Pseudomonas putida

   Meina He, Yongxin Tao ... Wenli Chen

   Pseudomonas putida coordinates chemotaxis and resistance to copper through the interaction between CheA and CsoR.
9. 1. Biochemistry and Chemical Biology
   2. Genetics and Genomics

   Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing

   Jiale Zhou, Ding Zhao ... Zhanjun Li

   The DRAM system enables antibody-free, bisulfite-free, and transcriptome-wide mapping of 5-methylcytosine in mRNA with high accuracy, stability, and sensitivity, even at ultralow RNA inputs.
10. 1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response

    Pavla Nedbalová, Nikola Kaislerova ... Tomáš Doležal

    Adenosine produced by transmethylation may act as a sensor of the balance between cell activity and nutrient supply.