Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology

   Phenylhydrazone-based Endoplasmic Reticulum Proteostasis Regulator Compounds with Enhanced Biological Activity

   Gabriel M Kline, Lisa Boinon ... R Luke Wiseman
2. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics

   Leonid Peshkin, Enrico maria Daldello ... Catherine Jessus

   A comprehensive resource describes protein abundance and phosphorylation dynamics during Xenopus oocyte maturation, serving as an essential tool for investigating the molecular mechanisms driving meiotic progression.
3. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Harnessing AlphaFold to reveal hERG channel conformational state secrets

   Khoa Ngo, Pei-Chi Yang ... Igor Vorobyov

   Customized AlphaFold-based modeling of distinct functional states of the hERG channel, a major drug anti-target, significantly improves drug affinity predictions, enhancing cardiac safety screening for arrhythmia risk.
4. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules

   Samantha J Cassell, Weiyan Li ... Jonathan R Whicher
5. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Occupancy of the HbYX hydrophobic pocket is sufficient to induce gate opening in the archaeal 20S proteasomes

   Janelle JY Chuah, Madalena R Daugherty, David M Smith
6. 1. Biochemistry and Chemical Biology

   Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress in mice

   Marwa O Mikati, Petra Erdmann-Gilmore ... Ream Al-Hasani

   An analytical approach increases spatiotemporal resolution, optimizes real-time, in vivo detection of Met- and Leu-enkephalin, and provides novel insight into the relationship between Met- and Leu-enkephalin following stress.
7. 1. Biochemistry and Chemical Biology
   2. Neuroscience

   Modular DNA Barcoding of Nanobodies Enables Multiplexed in situ Protein Imaging and High-throughput Biomolecule Detection

   Shilin Zhong, Ruiyu Wang ... Minmin Luo
8. 1. Biochemistry and Chemical Biology

   RNA: Searching for druggable targets

   Lana Heganovic, Luiz FM Passalacqua

   A strategy that analyzes the structural properties of RNA could help identify regions that are promising targets for antiviral drugs.
9. 1. Biochemistry and Chemical Biology

   Exploiting functional regions in the viral RNA genome as druggable entities

   Dehua Luo, Yingge Zheng ... Dengguo Wei

   SHAPE-MaP reveals functional RNA structures in the porcine epidemic diarrhea virus genome, enabling targeted siRNA design and offering a promising strategy to inhibit viral replication.
10. 1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Human eIF2A has a minimal role in translation initiation and in uORF-mediated translational control in HeLa cells

    Mykola Roiuk, Marilena Neff, Aurelio A Teleman

    Although eIF2A is thought to be a translation initiation factor, loss of eIF2A has no effect on cellular mRNA translation in either unstressed or stressed conditions.