Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Synergy between the small intrinsically disordered protein Hsp12 and trehalose sustain viability after desiccation

   Skylar Xantus Kim et al.
2. 1. Biochemistry and Chemical Biology
   2. Human Biology and Medicine

   Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism

   Erin G Conlon et al.
3. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Lipoate-binding proteins and specific lipoate-protein ligases in microbial sulfur oxidation reveal an atypcial role for an old cofactor

   Xinyun Cao et al.
4. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE

   Ioanna Oikonomidi et al.

   Secretion of the inflammatory cytokine TNF requires a protein called iTAP/FrmD8, which controls the cell surface stability of the TNF shedding machinery, iRhom2 and TACE/ADAM17.
5. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex

   Ulrike Künzel et al.

   The protein FRMD8 binds to iRhom and thereby stabilises the iRhom/ADAM17 complex, which is the primary trigger of inflammatory signalling.
6. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor

   Kathryn E Livingston et al.

   Opioid drug efficacy and allosteric modulation is measured using an active state sensor of the mu-opioid receptor.
7. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Multisite dependency of an E3 ligase controls monoubiquitylation-dependent cell fate decisions

   Achim Werner et al.
8. 1. Biochemistry and Chemical Biology
   2. Neuroscience

   Alzheimer’s Disease: The two shapes of the Tau protein

   Jeffery W Kelly

   Tau proteins can convert from an inert shape to a misfolded shape that seeds the growth of fibers that contribute to the pathology of Alzheimer's disease.
9. 1. Biochemistry and Chemical Biology
   2. Neuroscience

   Inert and seed-competent tau monomers suggest structural origins of aggregation

   Hilda Mirbaha et al.

   Tau protein exists as two conformational ensembles, one inert, and another that has intrinsic properties of self-association, triggers seeding in cells and in vitro, and is associated with Alzheimer's disease.
10. 1. Biochemistry and Chemical Biology
    2. Cell Biology

    Single-color, ratiometric biosensors for detecting signaling activities in live cells

    Brian L Ross et al.

    A novel panel of homoFRET biosensors that detect kinase and second messenger activity, called FLAREs, enables multiparameter imaging of signaling activities within a single live cell with a quantitative and ratiometric readout.