Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   NusG is an intrinsic transcription termination factor that stimulates motility and coordinates gene expression with NusA

   Zachary F Mandell et al.

   The general transcription elongation factor NusG functions as an intrinsic termination factor in Bacillus subtilis and together with NusA coordinates global gene expression including the motility regulon.
2. 1. Biochemistry and Chemical Biology
   2. Immunology and Inflammation

   In vitro proteasome processing of neo-splicetopes does not predict their presentation in vivo

   Gerald Willimsky et al.
3. 1. Biochemistry and Chemical Biology

   Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine

   Qiang Liu et al.
4. 1. Biochemistry and Chemical Biology

   Virus Engineering: ORACLE reveals a bright future to fight bacteria

   Willow Coyote-Maestas, James S Fraser

   A new way to alter the genome of bacteriophages helps produce large libraries of variants, allowing these bacteria-killing viruses to be designed to target species harmful to human health.
5. 1. Biochemistry and Chemical Biology

   Mapping the functional landscape of the receptor binding domain of T7 bacteriophage by deep mutational scanning

   Phil Huss et al.

   An unbiased mutational screen decodes the molecular basis of phage receptor interactions, identifies key functional regions determining activity and host range, and demonstrates the potential for engineering therapeutic phages.
6. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Complementary biosensors reveal different G-protein signaling modes triggered by GPCRs and non-receptor activators

   Mikel Garcia-Marcos

   Heterotrimeric G-proteins can be switched on not only by G-protein-coupled receptors but also by cytoplasmic proteins, resulting in different signaling mechanisms in cells depending on the specific type of activator.
7. 1. Biochemistry and Chemical Biology

   Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling

   Vidyasiri Vemulapalli et al.

   Monitoring SHP2 phosphoproteome dynamics identifies new substrate sites and sites protected from dephosphorylation by its SH2 domains, highlighting distinct scaffolding and catalytic activities in effecting a transmembrane signaling response.
8. 1. Biochemistry and Chemical Biology

   HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase

   Johannes Rudolph et al.

   The polymerase activity of PARP1 is converted to hydrolase activity upon binding of Histone Parylation Factor 1 (HPF1) with nucleosome activators.
9. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Transient kinetic studies of the antiviral Drosophila Dicer-2 reveal roles of ATP in self•nonself discrimination

   Raushan K Singh et al.
10. 1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice

    Jason D Plummer et al.

    Dietary selenium supplementation confers to mice all of the short-term healthspan benefits of the longevity-promoting intervention methionine restriction, and thus may represent a method to promote healthy aging in mammals.