Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology

   Inter-membrane association of the Sec and BAM translocons for bacterial outer-membrane biogenesis

   Sara Alvira et al.

   The protein translocation apparatus of the inner- (Sec) and outer-membrane (BAM) interact to form a trans-periplasmic super-complex capable of long-range, PMF-dependent conformational changes to facilitate efficient outer-membrane protein maturation.
2. 1. Biochemistry and Chemical Biology

   Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection

   Donghyuk Shin et al.

   A novel class of bacterial OTU deubiquitinases provides insights on the distinct roles of bacterial deubiquitinases in host–pathogen interactions.
3. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration

   Qi Yang et al.

   A critical role for glycosylation on viral entry and methods to use this knowledge to reduce SARS-CoV-2 infectivity has been demonstrated.
4. 1. Biochemistry and Chemical Biology

   Talin-activated vinculin interacts with branched actin networks to initiate bundles

   Rajaa Boujemaa-Paterski et al.

   At adhesion sites, talin-activated vinculin promotes interactions with the actin network that initiates bundles.
5. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Spreading of a mycobacterial cell surface lipid into host epithelial membranes promotes infectivity

   CJ Cambier et al.
6. 1. Biochemistry and Chemical Biology
   2. Neuroscience

   Probing the ionotropic activity of glutamate GluD2 receptor in HEK cells with genetically-engineered photopharmacology

   Damien Lemoine et al.

   A photoswitchable pore blocker was covalently attached to a cysteine-substituted glutamate delta 2 receptor, to provide optical control of its ion channel function.
7. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   SON and SRRM2 are essential for nuclear speckle formation

   İbrahim Avşar Ilik et al.

   Re-characterization of the targets of a commonly used nuclear speckle marker unexpectedly leads to the discovery of the elusive core of the nuclear speckles.
8. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   Spatially compartmentalized phase regulation of a Ca²⁺-cAMP-PKA oscillatory circuit

   Brian Tenner et al.

   Nanodomain clustering of cAMP effectors represents a novel mechanism of cAMP compartmentation within an oscillatory signaling circuit.
9. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   Nanoscale Signaling: Messages across time and space

   Sascha M Kuhn, André Nadler

   Compartmentalized oscillations of second messengers affect global cellular signaling.
10. 1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Uncovering the basis of protein-protein interaction specificity with a combinatorially complete library

    Thuy-Lan V Lite et al.

    A generalizable approach to understanding the logic of molecular recognition reveals the contributions of individual residues to the specificity of protein-protein interactions.