Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation

   Edmundo G Vides, Ayan Adhikari ... Suzanne R Pfeffer
2. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Distinct architectural requirements for the parS centromeric sequence of the pSM19035 plasmid partition machinery

   Andrea Volante, Juan Carlos Alonso, Kiyoshi Mizuuchi

   Unique sequence feature requirements for the plasmid centromere pSM19035-parS for ParA_pSM-ATPase activation byribbon-helix-helix-ParB_pSM, a non-CTPase centromere-binding protein, evince complex interaction gymnastics among the three reaction components necessary for plasmid partition, which is distinct from ParABS-systems involving helix-turn-helix-ParB-CTPases.
3. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Structural insight on the mechanism of an electron-bifurcating [FeFe] hydrogenase

   Chris Furlan, Nipa Chongdar ... James A Birrell

   Cryo-EM and particle classification techniques reveal how the electron-bifurcating [FeFe] hydrogenase from Thermotoga maritima multimerizes to connect distant active sites and reveal different conformational states that enable catalysis.
4. 1. Biochemistry and Chemical Biology
   2. Immunology and Inflammation

   Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using competing inerthydroxymethylene diphosphonate

   Hiroko Okawa, Takeru Kondo ... Ichiro Nishimura

   The targeted removal of legacy bisphosphonate from the jawbone by competitive equilibrium therapy not only elucidated the pathological mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) but also established a highly translatable therapeutic option for BRONJ.
5. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Kinesin-1, -2 and -3 motors use family-specific mechanochemical strategies to effectively compete with dynein during bidirectional transport

   Allison M Gicking, Tzu-Chen Ma ... William O Hancock
6. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Group II truncated haemoglobin YjbI prevents reactive oxygen species-induced protein aggregation in Bacillus subtilis

   Takeshi Imai, Ryuta Tobe ... Hisaaki Mihara
7. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells

   Nuria Vilaplana-Lopera, Vincent Cuminetti ... Paloma Garcia

   Interplay between AML and stromal cells can initiate a mechanism involving gap junctions where ROS is transferred from cancer cells to stromal cells which then produce acetate which can in return be absorbed/utilised by the cancer cells.
8. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes

   Stefania Monterisi, Johanna Michl ... Pawel Swietach
9. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Structure of Geobacter OmcZ filaments suggests extracellular cytochrome polymers evolved independently multiple times

   Fengbin Wang, Chi Ho Chan ... Daniel R Bond

   A cryo-EM structure of the bacterial OmcZ cytochrome filament provides evidence for the possibility that cytochrome polymers had multiple origins in bacteria.
10. 1. Biochemistry and Chemical Biology
    2. Cell Biology

    Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway

    Tolulope Sokoya, Jan Parolek ... Joost CM Holthuis