Editors for Chromosomes and Gene Expression

We aim to publish significant research, performed using genetic, biochemical and structural approaches, that relates to all aspects of the central dogma of biology, specifically DNA replication, repair and recombination, transcription and RNA processing, and translation. We welcome studies in organisms from bacteria to humans that provide new insights into the mechanisms of these processes – including how they are regulated, for example during cell differentiation – and the defects in these processes that contribute to disease. Read the latest research in this subject area.

Senior editors

  1. James Manley

    Columbia University, United States

    James Manley received a BS from Columbia University, a PhD from Stony Brook/Cold Spring Harbor Labs, and did postdoctoral work at MIT. He has been in the Department of Biological Sciences at Columbia University since 1980, was Chair from 1995–2001, and Julian Clarence Levi Professor of Life Sciences since 1995. His research interests center on understanding the mechanisms and regulation of gene expression in eukaryotes, especially with regard to mRNA splicing and 3’ end formation; how these processes are linked to transcription, cell signaling pathways, and maintenance of genomic stability; and how they contribute to cell differentiation and disease. He has authored or coauthored nearly 300 research articles and reviews on these topics, and is an ISI Highly Cited Researcher. Dr. Manley is a Fellow of the American Academy of Microbiology, the American Academy of Arts and Sciences, and the American Association for the Advancement of Science, and a member of the National Academy of Sciences.

    Expertise
    Chromosomes and Gene Expression
    Research focus
    chromosomes and gene expression
    transcription
    RNA processing
    translation
    RNA localization and turnover
    Experimental organism
    human
    S. cerevisiae
    Competing interests statement
    Jim Manley receives research support from the National Institutes of Health and Columbia’s Motor Neuron Center. He is currently an Associate Editor of Gene Expression and Editor of Molecular and Cellular Biology. He is also on the editorial boards of Genes and Development, RNA, Molecular Cell, BMC Molecular Biology, BMC Biology, Recent Patents on DNA & Gene Sequences, and Transcription.
  2. Gisela Storz

    National Institute of Child Health and Human Development, United States

    Gisela Storz has been an Investigator in the Eunice Kennedy Shriver Institute of Child Health and Human Development in Bethesda, Maryland since 1991. She obtained a BA in Biochemistry from the University of Colorado in 1984 and a PhD in Biochemistry from the University of California, Berkeley in 1988, where she studied the bacterial response to oxidative stress working with Bruce Ames. Her current work is focused on understanding gene regulation in response to environmental signals and elucidating the roles of small RNAs and small proteins of less than 50 amino acids in these regulatory networks. Dr. Storz was the recipient of the American Society for Microbiology Eli Lilly Award and is a member of the American Academy of Microbiology, American Academy of Arts and Sciences and US National Academy of Sciences.

    Expertise
    Microbiology and Infectious Disease
    Chromosomes and Gene Expression
    Research focus
    small noncoding RNAs
    oxidative stress
    gene regulation
    bacterial physiology
    regulatory RNAs
    Experimental organism
    E. coli
    Competing interests statement
    Gisela Storz is employed by the Intramural Program of the National Institutes of Health. She served on the Scientific Advisory Board of Max Planck Institute for Terrestrial Microbiology. In addition to being a Senior Editor for eLife, she is an Editor at RNA and on the Editorial Boards of mBio, Annual Reviews of Genetics and Microbiology Spectrum.
  3. Kevin Struhl

    Harvard Medical School, United States

    Kevin Struhl received a BS and MS from MIT, a PhD from Stanford University Medical School, and did postdoctoral work at the MRC Laboratory of Molecular Biology in Cambridge, UK. He has been in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School since 1982, was acting Chair from 1997–98, and has been the David Wesley Gaiser Professor since 1991. His research combines genetic, molecular, genomic, and evolutionary approaches to address a wide variety of fundamental questions about transcriptional regulatory mechanisms and chromatin structure in yeast. In addition, he is interested in elucidating transcriptional regulatory circuits that mediate the process of cellular transformation and the formation of cancer stem cells. He has authored or co-authored nearly 300 research articles and reviews, and is an ISI Highly Cited Researcher. He received the Eli Lilly Award in Microbiology and is a Distinguished Researcher at the Institute of Molecular Biology and Biotechnology in Crete. Dr. Struhl is a Fellow of the American Academy of Microbiology, the American Association for the Advancement of Science, the American Academy of Arts and Sciences, the National Academy of Sciences, and the National Academy of Medicine.

    Expertise
    Chromosomes and Gene Expression
    Cell Biology
    Research focus
    transcription mechanisms
    gene regulation
    chromatin
    mRNA decay
    biological function
    cellular transformation
    cancer stem cells
    Competing interests statement
    Kevin Struhl receives funding from the National Institutes of Health. He is on the Scientific Advisory Board of Sangamo, Inc and the Klarman Cell Observatory at the Broad Institute. He is on the editorial boards of Current Protocols in Molecular Biology and Epigenetics and Chromatin.
  4. Jessica Tyler

    Weill Cornell Medicine, United States

    Jessica Tyler was born in England in 1969. After graduating from the University of Sheffield with a Bachelors degree and the Hans Krebs Prize in Biochemistry, she performed her PhD studies at the MRC Virology Unit in Glasgow, Scotland. During her postdoctoral studies with Dr James Kadonaga at the University of California, San Diego, she identified the key chromatin assembly factors Anti-silencing Function 1 (Asf1) and characterized Chromatin Assembly Factor 1 (CAF-1) from Drosophila. In 2000, Dr Tyler started her first faculty position in the Department of Biochemistry and Molecular Genetics at the University of Colorado School of Medicine, Denver, USA. In the next 10 years, Dr Tyler revealed that chromatin assembly and disassembly not only regulates S phase events, but also gene expression and the DNA damage response. Dr Tyler was a Leukemia and Lymphoma Society Scholar and was awarded the Charlotte Friend Woman in Cancer Research Award for 2009 from the American Association of Cancer Research (AACR). Having risen rapidly to the rank of full professor at the University of Colorado, Dr Tyler moved in 2010 to the Department of Biochemistry and Molecular Biology at MD Anderson Cancer Center in Houston. Her recent work has extended to the broader influence of chromatin assembly on mitosis, aging and cancer. She is now in the Department of Epigenetics and Molecular Carcinogenesis, where she co-directs the Center for Cancer Epigenetics and holds the Edward Rotan Distinguished Professorship in Cancer Research. Her most proud achievement is being mother to 11 year-old triplets. In November 2015, she became a Professor in the Department of Pathology and Laboratory Medicine at Weill Cornell Medical College in New York.

    Expertise
    Chromosomes and Gene Expression
    Genetics and Genomics
    Research focus
    epigenetic regulation
    chromatin
    gene expression
    mitosis
    aging
    cancer
    Experimental organism
    S. cerevisiae
    Competing interests statement
    Previous funding has come from March of Dimes, Susan Komen, the Leukemia and Lymphoma Foundation, NIH, and CPRIT. Jessica Tyler serves on the editorial boards of Journal of Biological Chemistry, Molecular and Cellular Biology, and Chromatin and Epigenetics.
  5. K VijayRaghavan

    K VijayRaghavan

    National Centre for Biological Sciences, Tata Institute of Fundamental Research, India

    Vijay’s research aims to understand motor- and olfactory- circuit assembly: from deciphering how each component is made, interacts, and stabilises into functioning in the animal to allow behaviour in the real world. Related to the development of network function is its maintenance in the mature animal; another aspect of the work in the laboratory addresses how mature neurons and muscles are maintained. The laboratory uses a genetic approach, mainly using the fruit fly but also collaborating with those using mouse and cell-culture. VijayRaghavan is Secretary to the Government of India in the Ministry of Science and Technology in the Department of Biotechnology. He temporarily holds additional charge of the Department of Biotechnology. VijayRaghavan’s research continues at the National Centre for Biological Sciences (NCBS) of the Tata Institute of Fundamental Research (TIFR) in Bangalore, India, where he is Distinguished Professor. He studied engineering at the Indian Institute of Technology, Kanpur. His doctoral work was at TIFR, Mumbai and postdoctoral work at the California Institute of Technology. VijayRaghavan is a Fellow of the Royal Society, a Foreign Associate of the US National Academy of Sciences and a Foreign Associate of the European Molecular Biology Organization.

    Expertise
    Developmental Biology
    Chromosomes and Gene Expression
    Neuroscience
    Research focus
    genetics and genomics
    developmental biology
    neurogenetics
    neurobiology
    genetic basis of behavior
    Experimental organism
    D. melanogaster
    human
    mouse
    Competing interests statement
    K VijayRaghavan currently receives research support from the Indo–French research agency CEFIPRA, and core support from the National Centre for Biological Sciences (NCBS) of the Tata Institute of Fundamental Research (TIFR). Previous support was from the Rockefeller Foundation, the Wellcome Trust, the Indian Department of Science and Technology (DST), Department of Biotechnology (DBT), CEFIPRA, the Human Frontier Science Program (HFSP), and the US National Institutes of Health (NIH). VijayRaghavan serves on the Board of Governors of the Okinawa Institute of Science and Technology, is a member of the Advisory Committee of the Janelia Farm Research Campus of the HHMI, Chair of the Research Council of the Institute of Genomics and Integrative Biology, and Member of the Governing Council of the National Institute of Immunology. He is Associate Editor of BMC Developmental Biology, and a member of the editorial boards of Development, Seminars in Developmental Biology, and Bioconcepts. He is Chair of the Board of the Center for Cellular and Molecular Platforms (C-CAMP), a not-for-profit company of the National Centre for Biological Sciences and the stem cell institute, inStem, created to manage platform technologies and for technology transfer on the NCBS–inStem campus. He is a member of the board of the Madhuram Narayanan Centre for Exceptional Children, a not-for-profit school for disabled children in Chennai, and a member of the Board of Trustees of the Human Frontier Science Program.
  6. Cynthia Wolberger

    Johns Hopkins University School of Medicine, United States

    Cynthia Wolberger is a Professor of Biophysics and Biophysical Chemistry at the Johns Hopkins University School of Medicine, whose faculty she joined in 1991. She received her AB in Physics from Cornell University and her PhD in Biophysics from Harvard University, where she did thesis work on the structural basis of protein-DNA interactions under the guidance of Steve Harrison and Mark Ptashne. After a postdoctoral fellowship at the University of California, San Francisco with Bob Stroud, she worked on the crystal structures of homeodomain-DNA complexes in the laboratory of Carl Pabo at Johns Hopkins. Her earlier worked focused on the structural basis for combinatorial regulation of gene expression and the molecular mechanisms of the sirtuin family of protein deacetylases. Her current research centers on the mechanisms by which ubiquitin plays a signaling role in transcription and the DNA damage response. Wolberger was a recipient of the David and Lucile Packard Fellowship for Science and Engineering, a March of Dimes–Basil O’Conor Starter Scholar Award, and an American Cancer Society Junior Faculty Award, and was a Howard Hughes Medical Institute Investigator from 1994–2014. She received the Protein Society’s Dorothy Crowfoot Hodgkin Award and is a Fellow of the American Association for the Advancement of Science.

    Expertise
    Structural Biology and Molecular Biophysics
    Chromosomes and Gene Expression
    Biochemistry and Chemical Biology
    Research focus
    x-ray crystallography
    enzymology
    transcriptional regulation
    ubiquitin signaling
    Competing interests statement
    Cynthia Wolberger receives funding from the National Institutes of Health and the US–Israel Binational Science Foundation. She chairs the Scientific Advisory Committee of the RCSB Protein Data Bank and is on the external scientific advisory boards of the Advanced Photon Source and the Max Planck Institute for Biochemistry in Martinsried, Germany. She is a member of the Editorial Advisory Board of Protein Science, the Editorial Boards of Structure and Current Opinion in Structural Biology, and is a Faculty of 1000 section head in Transcription and Translation. Wolberger is also a member of the Scientific Advisory Board of Thermo Fisher Scientific.

Reviewing editors

  1. Karen Adelman

    Harvard Medical School, United States

    Expertise
    Chromosomes and Gene Expression
    Research focus
    chromatin structure
    gene expression
    transcription
  2. Andres Aguilera

    CABIMER, University of Seville, Spain

    Expertise
    Chromosomes and Gene Expression
    Research focus
    genome instability
    recombinational DNA repair
    R loops
    transcription-replication conflicts
    Experimental organism
    C. elegans
    S. cerevisiae
    human cells
  3. Asifa Akhtar

    Max Planck Institute for Immunobiology and Epigenetics, Germany

    Expertise
    Chromosomes and Gene Expression
    Genetics and Genomics
    Research focus
    gene expression
    chromatin biology
    epigenetics
    transcription
    Experimental organism
    Drosophila
  4. Richard Amasino

    University of Wisconsin-Madison, United States

    Expertise
    Plant Biology
    Genetics and Genomics
    Chromosomes and Gene Expression
    Research focus
    plant development and epigenetics
    Experimental organism
    arabidopsis thaliana
    brachypodium distachyon
  5. David Baulcombe

    Cambridge University, United Kingdom

    Expertise
    Genetics and Genomics
    Plant Biology
    Chromosomes and Gene Expression
    Research focus
    epigenetics
    RNA silencing
    plant microbe interactions and signaling
    Experimental organism
    arabidopsis thaliana
  6. Douglas L Black

    University of California, Los Angeles, United States

    Expertise
    Biochemistry and Chemical Biology
    Chromosomes and Gene Expression
    Research focus
    pre-mRNA splicing
    post-transcriptional gene regulation
  7. Benjamin J Blencowe

    University of Toronto, Canada

    Expertise
    Chromosomes and Gene Expression
    Genetics and Genomics
    Research focus
    RNA processing
    epigenomics
    transcriptome analyses
    Experimental organism
    human
    mouse
  8. Michael R Botchan

    University of California, Berkeley, United States

    Expertise
    Biochemistry and Chemical Biology
    Chromosomes and Gene Expression
    Research focus
    DNA replication
    DNA repair
    Experimental organism
    Drosophila
  9. Déborah Bourc'his

    Institut Curie, France

    Expertise
    Chromosomes and Gene Expression
    Developmental Biology
    Stem Cells and Regenerative Medicine
    Research focus
    epigenetics
    DNA methylation
    genomic imprinting
    transposons
    reproduction
    Experimental organism
    mouse
  10. Irwin Davidson

    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/UDS, France

    Expertise
    Biochemistry and Chemical Biology
    Cancer Biology
    Chromosomes and Gene Expression
    Research focus
    transcription
    chromatin
    genomics
    cancer
    Experimental organism
    human
    mouse
  11. Roger Davis

    University of Massachusetts Medical School, United States

    Expertise
    Cell Biology
    Chromosomes and Gene Expression
    Research focus
    signal transduction
    Experimental organism
    mouse
  12. Bernard de Massy

    Institute of Human Genetics, CNRS, France

    Expertise
    Chromosomes and Gene Expression
    Research focus
    recombination
    meiosis
    Experimental organism
    mouse
    S. cerevisiae
  13. Sebastian Deindl

    Uppsala University, Sweden

    Expertise
    Structural Biology and Molecular Biophysics
    Chromosomes and Gene Expression
    Research focus
    Single-molecule biophysics and structural biology
    chromatin remodeling machines
    chromatin remodeling
    helicases
    Experimental organism
    E. coli
    human
    S. cerevisiae
  14. Job Dekker

    University of Massachusetts Medical School, United States

    Expertise
    Computational and Systems Biology
    Chromosomes and Gene Expression
    Research focus
    spatial organisation of genomes
    chromatin interaction networks
    Experimental organism
    S. cerevisiae
  15. Abby Dernburg

    University of California, Berkeley, United States

    Expertise
    Cell Biology
    Chromosomes and Gene Expression
    Research focus
    meiosis
    synapsis
    meiotic recombination
    chromosome dynamics
    Experimental organism
    C. elegans
  16. Timothy Formosa

    University of Utah School of Medicine, United States

    Expertise
    Chromosomes and Gene Expression
    Research focus
    chromatin
    yeast genetics
    histone chaperones
    DNA replication
    transcription
    Experimental organism
    single-cell yeasts
  17. Thomas Gingeras

    Cold Spring Harbor Laboratory, United States

    Expertise
    Chromosomes and Gene Expression
    Genetics and Genomics
    Research focus
    non-coding RNA
    genome organisation
    transcriptome analyses
    DNA sequencing methods
    computational biology
    Experimental organism
    Drosophila
    human
    mouse
  18. Michael R Green

    University of Massachusetts Medical School, United States

    Expertise
    Cancer Biology
    Chromosomes and Gene Expression
    Human Biology and Medicine
    Research focus
    transcription
    pre-mRNA splicing
    cancer molecular biology
    oncology
    genetics
    functional genomics
    Experimental organism
    human
    mouse
    S. cerevisiae
  19. Rachel Green

    Johns Hopkins University School of Medicine, United States

    Expertise
    Biochemistry and Chemical Biology
    Chromosomes and Gene Expression
    Research focus
    mechanism of translation (bacterial and eukaryotic)
    ribosome profiling
    mRNA decay
    translational control
    ribosomes
  20. Wolf-Dietrich Heyer

    University of California, Davis, United States

    Expertise
    Chromosomes and Gene Expression
    Research focus
    double-stranded DNA breaks (DSBs)
    recombinational DNA repair
    homologous recombination
    genome instability
    Experimental organism
    S. cerevisiae
    human
  21. Alan G Hinnebusch

    Eunice Kennedy Shriver National Institute of Child Health and Human Development, United States

    Expertise
    Chromosomes and Gene Expression
    Research focus
    protein synthesis
    translational control
    Experimental organism
    S. cerevisiae
  22. Torben Heick Jensen

    Aarhus University, Denmark

    Expertise
    Chromosomes and Gene Expression
    Research focus
    RNA turnover
    RNA processing
    gene expression
    transcription
  23. Katherine Jones

    Salk Institute for Biological Studies, United States

    Expertise
    Chromosomes and Gene Expression
    Research focus
    transcriptional mechanisms
    transcription mechanisms
    HIV gene expression
    APC / regulation of expression of growth control genes
    Experimental organism
    human
  24. Matt Kaeberlein

    University of Washington, United States

    Expertise
    Chromosomes and Gene Expression
    Research focus
    aging
    longevity
    mitochondria
    proteostasis
    Experimental organism
    Yeast
    C. elegans
    mouse
    Dog
  25. Karla Kirkegaard

    Stanford University School of Medicine, United States

    Expertise
    Chromosomes and Gene Expression
    Microbiology and Infectious Disease
    Research focus
    drug resistance
    viral evolution
    dominant genes
    Experimental organism
    human
    mouse
    viruses
  26. Leonid Kruglyak

    University of California, Los Angeles, United States

    Expertise
    Chromosomes and Gene Expression
    Research focus
    phenotypic variation
    genetics of global gene expression
    population genetics
    complex diseases
    Experimental organism
    C. elegans
    S. cerevisiae
  27. Jeannie T Lee

    Massachusetts General Hospital, United States

    Expertise
    Chromosomes and Gene Expression
    Research focus
    non-coding RNA
    X-chromosome inactivation
    imprinting
    epigenetics
    chromatin
  28. Gail Mandel

    Oregon Health and Science University, United States

    Expertise
    Chromosomes and Gene Expression
    Neuroscience
    Research focus
    neuronal gene expression
    astrocyte biology
    Experimental organism
    mouse
  29. Andrew Morris

    University of Liverpool, United Kingdom

    Expertise
    Computational and Systems Biology
    Genetics and Genomics
    Chromosomes and Gene Expression
    Research focus
    statistical genetics
    genetic epidemiology
    methodological development
    genome-wide association studies
    Experimental organism
    human
  30. Timothy Nilsen

    Case Western Reserve University, United States

    Expertise
    Biochemistry and Chemical Biology
    Chromosomes and Gene Expression
    Research focus
    mRNA processing
    mechanism of miRNA function
    RNA protein interactions
    mRNP composition and function
    RNA biology
    Experimental organism
    Drosophila
  31. Stephen Parker

    University of Michigan, United States

    Expertise
    Genetics and Genomics
    Chromosomes and Gene Expression
    Computational and Systems Biology
    Research focus
    diabetes
    disease susceptibility
    functional genomics
    comparative genomics
    population genomics
    Experimental organism
    human
    mouse
    rat
  32. Nick J Proudfoot

    Oxford University, United Kingdom

    Expertise
    Cell Biology
    Chromosomes and Gene Expression
    Research focus
    mRNA processing
    transcription
    Experimental organism
    human
    S. cerevisiae
    S. pombe
  33. Danny Reinberg

    New York University School of Medicine, United States

    Expertise
    Cell Biology
    Chromosomes and Gene Expression
    Research focus
    epigenetics
    chromatin biology
    chromatin
    histones
    transcription
    Experimental organism
    human
  34. Kavitha Sarma

    Wistar Institute, United States

    Expertise
    Chromosomes and Gene Expression
    Research focus
    epigenetics
    chromatin
    non-coding RNA
    Experimental organism
    human
    mouse
  35. Xiaobing Shi

    Van Andel Institute, United States

    Expertise
    Chromosomes and Gene Expression
    Cancer Biology
    Research focus
    cancer epigenetics
    chromatin
    post-translational modifications of histones
    gene expression
  36. Robert H Singer

    Albert Einstein College of Medicine, United States

    Expertise
    Cell Biology
    Chromosomes and Gene Expression
    Research focus
    transcription
    mRNA localization
  37. Nahum Sonenberg

    McGill University, Canada

    Expertise
    Chromosomes and Gene Expression
    Neuroscience
    Cell Biology
    Research focus
    protein synthesis
    cell signalling and translation
    translational control of memory
    translation
    Experimental organism
    mouse
  38. Maria Spies

    University of Iowa, United States

    Expertise
    Chromosomes and Gene Expression
    Structural Biology and Molecular Biophysics
    Research focus
    molecular machines
    DNA repair
    single-molecule biophysics
    helicases
    homologous recombination
    DNA replication
    Experimental organism
    E. coli
    human
  39. Allan Spradling

    Carnegie Institution for Science, United States

    Expertise
    Developmental Biology
    Stem Cells and Regenerative Medicine
    Chromosomes and Gene Expression
    Research focus
    stem cell differentiation and morphogenesis
    ovary
    female reproduction
    polyploid cell
    epigenetics
    Experimental organism
    Drosophila
    mouse
  40. Jonathan P Staley

    University of Chicago, United States

    Expertise
    Cell Biology
    Chromosomes and Gene Expression
    Research focus
    catalysis
    proofreading
    RNA dynamics
  41. Bruce Stillman

    Cold Spring Harbor Laboratory, United States

    Expertise
    Chromosomes and Gene Expression
    Research focus
    DNA replication
    chromatin replication
    chromosome segregation
    Experimental organism
    human
    S. cerevisiae
  42. Elçin Ünal

    University of California, Berkeley, United States

    Expertise
    Chromosomes and Gene Expression
    Research focus
    gametogenesis
    aging
    age-induced cellular damage
    meiotic chromosome segregation
    Experimental organism
    S. cerevisiae
    C. elegans
  43. Juan Valcárcel

    Centre de Regulació Genòmica (CRG), Spain

    Expertise
    Chromosomes and Gene Expression
    Research focus
    RNA processing
    gene regulation
  44. Raymund Wellinger

    Université de Sherbrooke, Canada

    Expertise
    Chromosomes and Gene Expression
    Research focus
    telomere replication
    telomere biology
    telomerase
    DNA replication
    genomics of yeast
    Experimental organism
    S. cerevisiae
  45. Blake Wiedenheft

    Montana State University, United States

    Expertise
    Chromosomes and Gene Expression
    Microbiology and Infectious Disease
    Research focus
    bacteriophages
    genome editing
    host-parasite interactions
  46. Jerry L Workman

    Stowers Institute for Medical Research, United States

    Expertise
    Chromosomes and Gene Expression
    Genetics and Genomics
    Developmental Biology
    Research focus
    protein complexes
    chromatin modification
    regulation of gene transcription
    Experimental organism
    D. melanogaster
  47. Yukiko M Yamashita

    Howard Hughes Medical Institute, University of Michigan, United States

    Expertise
    Cell Biology
    Developmental Biology
    Chromosomes and Gene Expression
    Stem Cells and Regenerative Medicine
    Research focus
    stem cells
    stem cell niche
    asymmetric division
    spindle orientation
    centrosome
    Experimental organism
    D. melanogaster
  48. Daniel Zilberman

    John Innes Centre, United Kingdom

    Expertise
    Chromosomes and Gene Expression
    Genetics and Genomics
    Plant Biology
    Research focus
    chromatin biology
    epigenetics
    epigenomics
    evolution
    Experimental organism
    rice
    arabidopsis thaliana