Editors for Chromosomes and Gene Expression

We aim to publish significant research, performed using genetic, biochemical and structural approaches, that relates to all aspects of the central dogma of biology, specifically DNA replication, repair and recombination, transcription and RNA processing, and translation. We welcome studies in organisms from bacteria to humans that provide new insights into the mechanisms of these processes – including how they are regulated, for example during cell differentiation – and the defects in these processes that contribute to disease. Read the latest research in this subject area.

Senior editors

  1. James Manley

    Senior Editor

    James Manley received a BS from Columbia University, a PhD from Stony Brook/Cold Spring Harbor Labs, and did postdoctoral work at MIT. He has been in the Department of Biological Sciences at Columbia University since 1980, was Chair from 1995–2001, and Julian Clarence Levi Professor of Life Sciences since 1995. His research interests center on understanding the mechanisms and regulation of gene expression in eukaryotes, especially with regard to mRNA splicing and 3’ end formation; how these processes are linked to transcription, cell signaling pathways, and maintenance of genomic stability; and how they contribute to cell differentiation and disease. He has authored or coauthored nearly 300 research articles and reviews on these topics, and is an ISI Highly Cited Researcher. Dr. Manley is a Fellow of the American Academy of Microbiology, the American Academy of Arts and Sciences, and the American Association for the Advancement of Science, and a member of the National Academy of Sciences.

    Expertise
    Chromosomes and Gene Expression
    Research focus
    chromosomes and gene expression
    transcription
    RNA processing
    translation
    RNA localization and turnover
    Competing interests statement
    Jim Manley receives research support from the National Institutes of Health and Columbia’s Motor Neuron Center. He is currently an Associate Editor of Gene Expression and Editor of Molecular and Cellular Biology. He is also on the editorial boards of Genes and Development, RNA, Molecular Cell, BMC Molecular Biology, BMC Biology, Recent Patents on DNA & Gene Sequences, and Transcription.
  2. Aviv Regev

    Aviv Regev

    Senior Editor

    Aviv Regev is a computational biologist who joined the Broad Institute as a core member and MIT as a faculty member in 2006. Her work investigates how complex molecular networks function and evolve in the face of genetic and environmental changes, over time-scales ranging from minutes to millions of years. Regev received her MSc from Tel Aviv University, studying biology, computer science, and mathematics in the Interdisciplinary Program for the Fostering of Excellence, where she undertook research in both theoretical and experimental biology. She received her PhD in computational biology from Tel Aviv University. Prior to joining the Broad Institute, Regev was a fellow at the Bauer Center for Genomics Research at Harvard University, where she developed new approaches to the reconstruction of regulatory networks and modules from genomic data. Regev is also an associate professor in the Department of Biology at MIT
and director of the Klarman Cell Observatory at the Broad. Regev is the Director of the Cell Circuits Program at the Broad and a lead principal investigator for the Center for Cell Circuits at the Broad Institute, a Center of Excellence in Genomic Science (CEGS). Regev has been a Howard Hughes Medical Institute (HHMI) Early Career Scientist since 2009, and was named a Howard Hughes Medical Institute (HHMI) Investigator in 2013. She is a recipient of the NIH Director’s Pioneer Award, a Sloan fellowship from the Sloan Foundation, the Overton Prize from the International Society for Computational Biology, and the Earl and Thressa Stadtman Scholar Award from the American Society for Biochemistry and Molecular Biology (ASBMB).

    (Image Credit: Maria Nemchuk)

    Expertise
    Computational and Systems Biology
    Genetics and Genomics
    Chromosomes and Gene Expression
    Evolutionary Biology
    Cancer Biology
    Research focus
    systems biology
    molecular networks
    computational biology
    single cell genomics
    regulatory networks
    systems immunology
    gene regulation
    evolution
    Competing interests statement
    Aviv Regev receives funding from the Howard Hughes Medical Institute, the National Institutes of Health, and the Sloan Foundation. She is on the external advisory board of the San Diego Center for Systems Biology, the FAS Center for Systems Biology at Harvard, the Simons Institute for the Theory of Computing, the Jackson Laboratory, the European Molecular Biology Lab (EMBL), the SciLife Lab in Sweden, and ThermoFisher Scientific. She is on the advisory editorial board of Molecular Systems Biology and is an editorial board member of Genome Biology and Development. Regev is a consultant for Syros Phramaceuticals, GenePeeks, and CTIG (Cancer Therapeutics Innovation Group). Regev also worked for several years in the biotech industry in Israel, where she established and directed a bioinformatics research and development team at QBI, a functional genomics company.
  3. Gisela Storz

    Senior Editor

    Gisela Storz has been an Investigator in the Eunice Kennedy Shriver Institute of Child Health and Human Development in Bethesda, Maryland since 1991. She obtained a BA in Biochemistry from the University of Colorado in 1984 and a PhD in Biochemistry from the University of California, Berkeley in 1988, where she studied the bacterial response to oxidative stress working with Bruce Ames. Her current work is focused on understanding gene regulation in response to environmental signals and elucidating the roles of small RNAs and small proteins of less than 50 amino acids in these regulatory networks. Dr. Storz was the recipient of the American Society for Microbiology Eli Lilly Award and is a member of the American Academy of Microbiology, American Academy of Arts and Sciences and US National Academy of Sciences.

    Expertise
    Microbiology and Infectious Disease
    Chromosomes and Gene Expression
    Research focus
    small noncoding RNAs
    oxidative stress
    gene regulation
    bacterial physiology
    regulatory RNAs
    Experimental organism
    E. coli
    Competing interests statement
    Gisela Storz is employed by the Intramural Program of the National Institutes of Health. She served on the Scientific Advisory Board of Max Planck Institute for Terrestrial Microbiology. In addition to being a Senior Editor for eLife, she is an Editor at RNA and on the Editorial Boards of mBio, Annual Reviews of Genetics and Microbiology Spectrum.
  4. Kevin Struhl

    Senior Editor

    Kevin Struhl received a BS and MS from MIT, a PhD from Stanford University Medical School, and did postdoctoral work at the MRC Laboratory of Molecular Biology in Cambridge, UK. He has been in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School since 1982, was acting Chair from 1997–98, and has been the David Wesley Gaiser Professor since 1991. His research combines genetic, molecular, genomic, and evolutionary approaches to address a wide variety of fundamental questions about transcriptional regulatory mechanisms and chromatin structure in yeast. In addition, he is interested in elucidating transcriptional regulatory circuits that mediate the process of cellular transformation and the formation of cancer stem cells. He has authored or co-authored nearly 300 research articles and reviews, and is an ISI Highly Cited Researcher. He received the Eli Lilly Award in Microbiology and is a Distinguished Researcher at the Institute of Molecular Biology and Biotechnology in Crete. Dr. Struhl is a Fellow of the American Academy of Microbiology, the American Association for the Advancement of Science, the American Academy of Arts and Sciences, the National Academy of Sciences, and the National Academy of Medicine.

    Expertise
    Chromosomes and Gene Expression
    Research focus
    transcription mechanisms
    gene regulation
    chromatin
    mRNA decay
    biological function
    cellular transformation
    cancer stem cells
    Competing interests statement
    Kevin Struhl receives funding from the National Institutes of Health. He is on the Scientific Advisory Board of Sangamo, Inc and the Klarman Cell Observatory at the Broad Institute. He is on the editorial boards of Current Protocols in Molecular Biology and Epigenetics and Chromatin.
  5. Jessica Tyler

    Senior Editor

    Jessica Tyler was born in England in 1969. After graduating from the University of Sheffield with a Bachelors degree and the Hans Krebs Prize in Biochemistry, she performed her PhD studies at the MRC Virology Unit in Glasgow, Scotland. During her postdoctoral studies with Dr James Kadonaga at the University of California, San Diego, she identified the key chromatin assembly factors Anti-silencing Function 1 (Asf1) and characterized Chromatin Assembly Factor 1 (CAF-1) from Drosophila. In 2000, Dr Tyler started her first faculty position in the Department of Biochemistry and Molecular Genetics at the University of Colorado School of Medicine, Denver, USA. In the next 10 years, Dr Tyler revealed that chromatin assembly and disassembly not only regulates S phase events, but also gene expression and the DNA damage response. Dr Tyler was a Leukemia and Lymphoma Society Scholar and was awarded the Charlotte Friend Woman in Cancer Research Award for 2009 from the American Association of Cancer Research (AACR). Having risen rapidly to the rank of full professor at the University of Colorado, Dr Tyler moved in 2010 to the Department of Biochemistry and Molecular Biology at MD Anderson Cancer Center in Houston. Her recent work has extended to the broader influence of chromatin assembly on mitosis, aging and cancer. She is now in the Department of Epigenetics and Molecular Carcinogenesis, where she co-directs the Center for Cancer Epigenetics and holds the Edward Rotan Distinguished Professorship in Cancer Research. Her most proud achievement is being mother to 11 year-old triplets. In November 2015, she became a Professor in the Department of Pathology and Laboratory Medicine at Weill Cornell Medical College in New York.

    Expertise
    Chromosomes and Gene Expression
    Research focus
    epigenetic regulation
    chromatin
    gene expression
    mitosis
    aging
    cancer
    Competing interests statement
    Previous funding has come from March of Dimes, Susan Komen, the Leukemia and Lymphoma Foundation, NIH, and CPRIT. Jessica Tyler serves on the editorial boards of Journal of Biological Chemistry, Molecular and Cellular Biology, and Chromatin and Epigenetics.

Reviewing editors

  1. Abby Dernburg

    University of California, Berkeley, United States

    Expertise
    Cell Biology
    Chromosomes and Gene Expression
    Research focus
    meiosis
    synapsis
    meiotic recombination
    chromosome dynamics
    Experimental organism
    C. elegans
  2. Raymund Wellinger

    Université de Sherbrooke, Canada

    Expertise
    Chromosomes and Gene Expression
    Research focus
    telomere replication
    telomere biology
    telomerase
    DNA replication
    genomics of yeast
    Experimental organism
    S. cerevisiae
  3. Bruce Stillman

    Cold Spring Harbor Laboratory, United States

    Expertise
    Chromosomes and Gene Expression
    Research focus
    DNA replication
    chromatin replication
    chromosome segregation
    Experimental organism
    human
    S. cerevisiae
  4. A. Thomas Look

    Dana-Farber Cancer Institute, United States

    Expertise
    Cancer Biology
    Chromosomes and Gene Expression
    Human Biology and Medicine
    Research focus
    neuroblastoma
    acute leukemia
    hematopoietic malignancies
    cancer genetics
    Experimental organism
    human
    mouse
    zebrafish
  5. Matt Kaeberlein

    University of Washington, United States

    Expertise
    Chromosomes and Gene Expression
    Research focus
    aging
    longevity
    mitochondria
    proteostasis
    Experimental organism
    Yeast
    C. elegans
    mouse
    Dog
  6. Elçin Ünal

    University of California, Berkeley, United States

    Expertise
    Chromosomes and Gene Expression
    Research focus
    gametogenesis
    aging
    age-induced cellular damage
    meiotic chromosome segregation
    Experimental organism
    S. cerevisiae
    C. elegans
  7. Kavitha Sarma

    Wistar Institute, United States

    Expertise
    Biochemistry and Chemical Biology
    Chromosomes and Gene Expression
    Research focus
    epigenetics
    chromatin
    noncoding RNA
    Experimental organism
    human
    mouse
  8. Wolf-Dietrich Heyer

    University of California, Davis, United States

    Expertise
    Chromosomes and Gene Expression
    Research focus
    double-stranded DNA breaks (DSBs)
    recombinational DNA repair
    homologous recombination
    genome instability
    Experimental organism
    S. cerevisiae
    human
  9. Blake Wiedenheft

    Montana State University, United States

    Expertise
    Chromosomes and Gene Expression
    Microbiology and Infectious Disease
    Research focus
    bacteriophages
    genome editing
    host-parasite interactions
  10. Karen Adelman

    Harvard Medical School, United States

    Expertise
    Chromosomes and Gene Expression
    Research focus
    chromatin structure
    gene expression
    transcription
  11. Andres Aguilera

    University of Seville, Spain

    Expertise
    Chromosomes and Gene Expression
    Research focus
    genome instability
    recombinational DNA repair
    R loops
    transcription-replication conflicts
    Experimental organism
    C. elegans
    S. cerevisiae
  12. Asifa Akhtar

    Max Planck Institute for Immunobiology and Epigenetics, Germany

    Expertise
    Chromosomes and Gene Expression
    Genetics and Genomics
    Research focus
    gene expression
    chromatin biology
    epigenetics
    transcription
    Experimental organism
    Drosophila
  13. Douglas L Black

    University of California, Los Angeles, United States

    Expertise
    Biochemistry and Chemical Biology
    Chromosomes and Gene Expression
    Research focus
    pre-mRNA splicing
    post-transcriptional gene regulation
  14. Benjamin J Blencowe

    University of Toronto, Canada

    Expertise
    Chromosomes and Gene Expression
    Genetics and Genomics
    Research focus
    RNA processing
    epigenomics
    transcriptome analyses
  15. Michael R Botchan

    University of California, Berkeley, United States

    Expertise
    Biochemistry and Chemical Biology
    Chromosomes and Gene Expression
    Research focus
    DNA replication
    DNA repair
    Experimental organism
    Drosophila
  16. Irwin Davidson

    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/UDS, France

    Expertise
    Biochemistry and Chemical Biology
    Cancer Biology
    Chromosomes and Gene Expression
    Research focus
    transcription
    chromatin
    cancer
  17. Roger Davis

    University of Massachusetts Medical School, United States

    Expertise
    Cell Biology
    Chromosomes and Gene Expression
    Research focus
    signal transduction
  18. Bernard de Massy

    Institute of Human Genetics, CNRS, France

    Expertise
    Chromosomes and Gene Expression
    Research focus
    recombination
    meiosis
  19. Job Dekker

    University of Massachusetts Medical School, United States

    Expertise
    Computational and Systems Biology
    Chromosomes and Gene Expression
    Research focus
    spatial organisation of genomes
    chromatin interaction networks
  20. Timothy Formosa

    University of Utah, United States

    Expertise
    Chromosomes and Gene Expression
    Research focus
    chromatin
    yeast genetics
    histone chaperones
    DNA replication
    transcription
    Experimental organism
    single-cell yeasts
  21. Thomas Gingeras

    Cold Spring Harbor Laboratory, United States

    Expertise
    Chromosomes and Gene Expression
    Genetics and Genomics
    Research focus
    noncoding RNA
    genome organisation
    transcriptome analyses
    DNA sequencing methods
    Experimental organism
    Drosophila
  22. Michael R Green

    University of Massachusetts Medical School, United States

    Expertise
    Cancer Biology
    Chromosomes and Gene Expression
    Human Biology and Medicine
    Research focus
    RNA splicing
    cancer molecular biology
  23. Rachel Green

    Johns Hopkins University School of Medicine, United States

    Expertise
    Biochemistry and Chemical Biology
    Chromosomes and Gene Expression
    Research focus
    mechanism of translation (bacterial and eukaryotic)
    ribosome profiling
    mRNA decay
    translational control
    ribosomes
  24. Alan G Hinnebusch

    National Institute of Child Health and Human Development, United States

    Expertise
    Chromosomes and Gene Expression
    Research focus
    protein synthesis
    translational control
  25. Torben Heick Jensen

    Aarhus University, Denmark

    Expertise
    Chromosomes and Gene Expression
    Research focus
    RNA turnover
    RNA processing
    gene expression
    transcription
  26. Katherine Jones

    Salk Institute for Biological Studies, United States

    Expertise
    Chromosomes and Gene Expression
    Research focus
    transcriptional mechanisms
    transcription mechanisms
    HIV gene expression
    APC / regulation of expression of growth control genes
  27. Karla Kirkegaard

    Stanford University School of Medicine, United States

    Expertise
    Chromosomes and Gene Expression
    Microbiology and Infectious Disease
    Research focus
    drug resistance
    viral evolution
    dominant genes
    Experimental organism
    human
    mouse
    viruses
  28. Stephen C Kowalczykowski

    University of California, Davis, United States

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Chromosomes and Gene Expression
    Research focus
    recombinational DNA repair
    single-molecule biophysics
    DNA-protein interactions
    Experimental organism
    E. coli
    S. cerevisiae
    human
  29. Leonid Kruglyak

    University of California, Los Angeles, United States

    Expertise
    Chromosomes and Gene Expression
    Research focus
    phenotypic variation
    genetics of global gene expression
    population genetics
    complex diseases
    Experimental organism
    C. elegans
    S. cerevisiae
  30. Jeannie T Lee

    Massachusetts General Hospital, United States

    Expertise
    Chromosomes and Gene Expression
    Research focus
    noncoding RNA
    X-chromosome inactivation
    imprinting
    epigenetics
    chromatin
  31. Gail Mandel

    Oregon Health and Science University, United States

    Expertise
    Chromosomes and Gene Expression
    Neuroscience
    Research focus
    neuronal gene expression
    astrocyte biology
  32. Timothy Nilsen

    Case Western Reserve University, United States

    Expertise
    Biochemistry and Chemical Biology
    Chromosomes and Gene Expression
    Research focus
    mRNA processing
    mechanism of miRNA function
    RNA protein interactions
    mRNP composition and function
    RNA biology
    Experimental organism
    Drosophila
  33. Nick J Proudfoot

    Oxford University, United Kingdom

    Expertise
    Cell Biology
    Chromosomes and Gene Expression
    Research focus
    mRNA processing
    transcription
  34. Danny Reinberg

    New York University, United States

    Expertise
    Cell Biology
    Chromosomes and Gene Expression
    Research focus
    epigenetics
    chromatin biology
    chromatin
    histones
    transcription
  35. Robert H Singer

    Albert Einstein College of Medicine, United States

    Expertise
    Cell Biology
    Chromosomes and Gene Expression
    Research focus
    transcription
    mRNA localization
  36. Nahum Sonenberg

    McGill University, Canada

    Expertise
    Chromosomes and Gene Expression
    Neuroscience
    Research focus
    protein synthesis
    cell signalling and translation
    translational control of memory
  37. Allan Spradling

    Carnegie Institution for Science, United States

    Expertise
    Developmental Biology and Stem Cells
    Chromosomes and Gene Expression
    Research focus
    stem cell differentiation and morphogenesis
    ovary
    female reproduction
    polyploid cell
    epigenetics
    Experimental organism
    Drosophila
  38. Jonathan P Staley

    University of Chicago, United States

    Expertise
    Cell Biology
    Chromosomes and Gene Expression
    Research focus
    catalysis
    proofreading
    RNA dynamics
  39. Juan Valcárcel

    Centre for Genomic Regulation, Spain

    Expertise
    Chromosomes and Gene Expression
    Research focus
    RNA processing
    gene regulation
  40. Cynthia Wolberger

    Johns Hopkins University School of Medicine, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Chromosomes and Gene Expression
    Research focus
    x-ray crystallography
    enzymology
    transcriptional regulation
    ubiquitin signaling
  41. Jerry L Workman

    Stowers Institute for Medical Research, United States

    Expertise
    Chromosomes and Gene Expression
    Genetics and Genomics
    Research focus
    protein complexes
    chromatin modification
    regulation of gene transcription
    Experimental organism
    S. cerevisiae
  42. Yukiko M Yamashita

    Howard Hughes Medical Institute, University of Michigan, United States

    Expertise
    Cell Biology
    Developmental Biology and Stem Cells
    Chromosomes and Gene Expression
    Research focus
    stem cells
    stem cell niche
    asymmetric division
    spindle orientation
    centrosome
    Experimental organism
    D. melanogaster
  43. Daniel Zilberman

    John Innes Centre, United Kingdom

    Expertise
    Chromosomes and Gene Expression
    Genetics and Genomics
    Plant Biology
    Research focus
    chromatin biology
    epigenetics
    epigenomics
    evolution
    Experimental organism
    rice
    arabidopsis thaliana