Chromosomes and Gene Expression

Chromosomes and Gene Expression

eLife publishes research ranging from transcription and RNA processing to epigenetics and chromatin biology. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    A transcriptomic atlas of Aedes aegypti reveals detailed functional organization of major body parts and gut regional specializations in sugar-fed and blood-fed adult females

    Bretta Hixson et al.
    RNAseq profiles of female Aedes body parts, gut regions, and blood-fed guts provide insight into the anatomical patterning of immune and digestive function, and demonstrate the sequential induction of multiple peptidase cohorts over the course of blood meal digestion.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Cohesin-dependence of neuronal gene expression relates to chromatin loop length

    Lesly Calderon et al.
    Cohesin is required for the expression of neuronal genes that engage in long chromatin loops, while short-range enhancer-promoter loops can form in the absence of cohesin.
    1. Chromosomes and Gene Expression

    Inositol polyphosphate multikinase physically binds to the SWI/SNF complex and modulates BRG1 occupancy in mouse embryonic stem cells

    Jiyoon Beon et al.
    Inositol polyphosphate multikinase physically binds to the core subunits of SWI/SNF complex and plays an important role in regulating BRG1 occupancy and BRG-mediated chromatin accessibility in mouse embryonic stem cells.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Enhanced C/EBPβ function promotes hyperplastic versus hypertrophic fat tissue growth and prevents steatosis in response to high-fat diet feeding

    Christine Müller et al.
    Gene regulation by C/EBPβ determines how surplus of dietary fat is stored, which has consequences for metabolic health.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    SARS-CoV-2 Nsp14 mediates the effects of viral infection on the host cell transcriptome

    Michela Zaffagni et al.
    In the context of SARS-CoV-2 infection, Nsp14 alters gene expression of the host cell through the interaction with the cellular enzyme IMPDH2.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genetic loci and metabolic states associated with murine epigenetic aging

    Khyobeni Mozhui et al.
    Age-dependent changes in DNA methylation are tightly coupled to the metabolic state, and is partly under genetic regulation, and longer lifespan is associated with lower epigenetic entropy at CpGs that increase in methylation with age.

Senior editors

  1. James Manley
    Columbia University, United States
  2. Gisela Storz
    National Institute of Child Health and Human Development, United States
  3. Kevin Struhl
    Harvard Medical School, United States
  4. See more editors