Chromosomes and Gene Expression

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Neuroscience

   A transcriptomic taxonomy of Drosophila circadian neurons around the clock

   Dingbang Ma et al.

   Drosophila clock neurons manifest remarkable heterogeneity, which might be generally true and help explain why Drosophila has a sophisticated behavioral repertoire despite a tiny brain of about 100,000 neurons.
2. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   Mutations in SKI in Shprintzen–Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization

   Ilaria Gori et al.

   The mechanism underlying Shprintzen–Goldberg syndrome is solved and reveals that missense mutations in the transcriptional repressor SKI abolish ligand-induced SKI degradation, which results in attenuation of TGF-β transcriptional responses.
3. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   A novel motif of Rad51 serves as an interaction hub for recombination auxiliary factors

   Negar Afshar et al.

   Although Rad51 is the central protein involved in recombinational DNA repair, multiple auxiliary factors potentiate its activity by binding to a single, evolutionarily conserved motif.
4. 1. Chromosomes and Gene Expression

   The RNA-binding protein SFPQ preserves long-intron splicing and regulates circRNA biogenesis in mammals

   Lotte Victoria Winther Stagsted et al.

   Transcriptome and eCLIP analyses in mouse and human reveal splicing factor proline/glutamine rich (SFPQ) as a conserved and critical guardian of long-intron integrity, splicing, and circular RNA (circRNA) production.
5. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Telomeric double-strand DNA-binding proteins DTN-1 and DTN-2 ensure germline immortality in Caenorhabditis elegans

   Io Yamamoto et al.

   The discovery of non-canonical telomeric dsDNA-binding proteins in Caenorhabditis elegans reveal their contribution in the maintenance of telomere length and germline immortality.
6. 1. Chromosomes and Gene Expression

   Checkpoint inhibition of origin firing prevents inappropriate replication outside of S-phase

   Mark C Johnson et al.

   The S-phase checkpoint has roles in all phases of the cell cycle, which has implications for the majority of cancers that lack cell cycle controls.
7. 1. Chromosomes and Gene Expression
   2. Physics of Living Systems

   The interplay between asymmetric and symmetric DNA loop extrusion

   Edward J Banigan, Leonid A Mirny

   Models of chromosome compaction by condensins demonstrate that two-sided loop extrusion and long residence times are required for high compaction, suggesting a tight coupling between these two properties in vivo.
8. 1. Chromosomes and Gene Expression

   Dose-dependent action of the RNA binding protein FOX-1 to relay X-chromosome number and determine C. elegans sex

   Behnom Farboud et al.

   RNA binding protein FOX-1 functions as a dose-dependent X-signal element to communicate X-chromosome number and determine nematode sex by controlling alternative non-productive pre-mRNA splicing of the master sex-determination switch gene.
9. 1. Chromosomes and Gene Expression

   Yeast Nuak1 phosphorylates histone H3 threonine 11 in low glucose stress by the cooperation of AMPK and CK2 signaling

   Seunghee Oh et al.

   Yeast Nuak1 is an AMPK and CK2 dependent H3 T11 kinase.
10. 1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Gene regulation gravitates toward either addition or multiplication when combining the effects of two signals

    Eric M Sanford et al.

    When two signals increase transcription of the same gene, their combined effect tends to reflect either the sum of the individual increases or the product of the individual fold-changes.