Chromosomes and Gene Expression

Latest articles

1. 1. Cell Biology
   2. Chromosomes and Gene Expression

   STAG2 promotes the myelination transcriptional programin oligodendrocytes

   Ningyan Cheng et al.
2. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   ATP binding facilitates target search of SWR1 chromatin remodeler by promoting one-dimensional diffusion on DNA

   Claudia C Carcamo et al.

   In vitro single-particle tracking reveals that ATP binding increases the one-dimensional diffusion of yeast chromatin remodeler SWR1 on DNA stretched between optical tweezers and diffusion is confined by protein roadblocks and nucleosomes.
3. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Polysome-CAGE of TCL1-driven chronic lymphocytic leukemia revealed multiple N-terminally altered epigenetic regulators and a translation stress signature

   Ariel Ogran et al.

   Examination of the changes in the transcription start site selection in TCL1-driven chronic lymphocytic leukemia and their impact on mRNA translation revealed a marked elevation of intra-genic cryptic promoters, which are predicted to generate multiple N-terminally truncated or modified proteins.
4. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Hematopoietic plasticity mapped in Drosophila and other insects

   Dan Hultmark, István Andó

   A critical analysis of recent single-cell transcriptomic studies of Drosophila blood cells confirms the extreme plasticity of the major phagocyte class, identifies a new class of blood cell, and suggests relationships to blood cells in other insects.
5. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase

   Ryo Fujisawa et al.
6. 1. Chromosomes and Gene Expression

   Genetic dissection of the RNA polymerase II transcription cycle

   Shao-Pei Chou et al.

   Natural genetic variation reveals how DNA sequence impacts core transcriptional processes of initiation, pause, and termination.
7. 1. Chromosomes and Gene Expression
   2. Developmental Biology

   Rapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons

   Lewis Macdonald et al.

   Auxin-inducible degradation of CRISPR-tagged endogenous proteins in mice reveals cell-type-specific dependence on the mitotic chromosome condensation proteins.
8. 1. Cell Biology
   2. Chromosomes and Gene Expression

   On demand expression control of endogenous genes with DExCon, DExogron and LUXon reveals differential dynamics of Rab11 family members

   Jakub Gemperle et al.

   DExCon, LUXon, and DExogron approaches simultaneously block endogenous gene expression and permit tuning of re-expression levels in time and space; proof-of-principle reveals unforeseen differences in protein kinetics, cargo handling, and cell migration regulation between closely related Rab11 family members.
9. 1. Chromosomes and Gene Expression

   Dynamic spreading of chromatin-mediated gene silencing and reactivation between neighboring genes in single cells

   Sarah Lensch et al.

   In a synthetic system, spreading of chromatin-mediated silencing to nearby genes depends on distance and can bypass genetic insulators, while reactivation after release of gene targeting is coordinated by insulators and promoters.
10. 1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance

    Eriko Matsuura-Suzuki et al.

    METTL18 methylates histidine 245 of ribosomal protein RPL3, retards ribosome traversal at tyrosine codons, and thus ensures nascent protein folding for proteostasis maintenance.