Chromosomes and Gene Expression

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Immunology and Inflammation

   SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX

   Allison R Wagner, Chi G Weindel ... Kristin L Patrick

   The splicing factor SRSF6 helps regulate antiviral immunity and mitochondrial membrane integrity by balancing the abundance of two alternatively spliced isoforms of the apoptotic protein BAX.
2. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Drosophila SUMM4 complex couples insulator function and DNA replication control

   Evgeniya N Andreyeva, Alexander V Emelyanov ... Dmitry V Fyodorov
3. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Nucleotide-level linkage of transcriptional elongation and polyadenylation

   Joseph V Geisberg, Zarmik Moqtaderi ... Kevin Struhl
4. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   N6-methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast

   Radhika A Varier, Theodora Sideri ... Folkert Jacobus van Werven
5. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   Mechanisms governing target search and binding dynamics of hypoxia-inducible factors

   Yu Chen, Claudia Cattoglio ... Xavier Darzacq

   Live-cell single particle tracking reveals the intrinsically disordered regions of transcription factors playing an unanticipated role in the nuclear search and chromatin binding process leading to functional target site selectivity and gene activation.
6. 1. Chromosomes and Gene Expression

   Mcm2 promotes stem cell differentiation via its ability to bind H3-H4

   Xiaowei Xu, Xu Hua ... Zhiguo Zhang

   Mcm2 promotes mouse embryonic stem cells differentiation through manipulating chromatin landscapes at bivalent chromatin domains.
7. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   m⁶A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5' splice site

   Matthew T Parker, Beth K Soanes ... Gordon Grant Simpson
8. 1. Chromosomes and Gene Expression

   KAT2-mediated acetylation switches the mode of PALB2 chromatin association to safeguard genome integrity

   Marjorie Fournier, Amélie Rodrigue ... Fumiko Esashi

   The lysine acetyltransferases KAT2A and KAT2B regulate the dynamic chromatin association of the tumour suppressor protein PALB2, protecting active genes and promoting DNA damage repair in a context-dependent manner.
9. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   Promoter sequence and architecture determine expression variability and confer robustness to genetic variants

   Hjorleifur Einarsson, Marco Salvatore ... Robin Andersson
10. 1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Characterization of sequence determinants of enhancer function using natural genetic variation

    Marty G Yang, Emi Ling ... Thomas Vierbuchen

    Large-scale, allele-resolved mapping of cis-regulatory function in F₁-hybrid mice reveals sequence determinants that control transcription factor binding and enhancer activity in native chromatin context.