Chromosomes and Gene Expression

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   A prion accelerates proliferation at the expense of lifespan

   David M Garcia et al.

   In its capacity to switch into a heritable, prionogenic form, a conserved RNA-modifying enzyme epigenetically alters fundamental growth, aging, and protein synthesis properties of eukaryotic cells.
2. 1. Chromosomes and Gene Expression

   SUV39 SET domains mediate crosstalk of heterochromatic histone marks

   Alessandro Stirpe et al.

   Clr4, a highly conserved SUV39 histone methyltransferase, requires its SET domain to sense histone H3K14 ubiquitination in order to maintain heterochromatin and H3K9 methylation.
3. 1. Chromosomes and Gene Expression
   2. Microbiology and Infectious Disease

   A nascent polypeptide sequence modulates DnaA translation elongation in response to nutrient availability

   Michele Felletti et al.

   Specific amino acids in the N-terminus of the replication initiator protein DnaA inhibit translation elongation upon carbon starvation, illustrating that the identity of the N-terminal amino acids of a protein can modulate protein synthesis yield under changing conditions.
4. 1. Chromosomes and Gene Expression
   2. Developmental Biology

   A XRCC4 mutant mouse, a model for human X4 syndrome, reveals interplays with Xlf, PAXX, and ATM in lymphoid development

   Benoit Roch et al.
5. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Comparison of transcriptional initiation by RNA polymerase II across eukaryotic species

   Natalia Petrenko, Kevin Struhl
6. 1. Chromosomes and Gene Expression
   2. Evolutionary Biology

   Enhanced Cas12a multi-gene regulation using a CRISPR array separator

   Jens P Magnusson et al.
7. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   The interplay of RNA:DNA hybrid structure and G-quadruplexes determines the outcome of R-loop-replisome collisions

   Charanya Kumar et al.
8. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   A precisely adjustable, variation-suppressed eukaryotic transcriptional controller to enable genetic discovery

   Asli Azizoglu et al.

   A new gene expression tool enables precise control of protein dosage over a large range and paves the way for new genetic discoveries.
9. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome

   Luka Bacic et al.
10. 1. Chromosomes and Gene Expression

    Linker histone H1.8 inhibits chromatin binding of condensins and DNA topoisomerase II to tune chromosome length and individualization

    Pavan Choppakatla et al.

    Linker histone H1.8 shapes mitotic chromosomes by tuning the number and size of condensin-dependent DNA loops and suppressing condensin and DNA topoisomerase II-dependent individualization.