Chromosomes and Gene Expression

Latest articles

1. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer

   Lili Liao et al.

   Major secondary tumor suppressors in kidney cancer are required to maintain the activity of a tumor suppressive transcription factor after the loss of the primary tumor suppressor VHL.
2. 1. Chromosomes and Gene Expression

   Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery

   Peter Tonzi et al.
3. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Chromatin accessibility dynamics across C. elegans development and ageing

   Jürgen Jänes et al.

   Profiling chromatin accessibility and nuclear transcription across Caenorhabditis elegans development and ageing generated the first map of transcriptional regulatory elements and their activities across an animal's life.
4. 1. Chromosomes and Gene Expression
   2. Microbiology and Infectious Disease

   Changes in mRNA abundance drive shuttling of RNA binding proteins, linking cytoplasmic RNA degradation to transcription

   Sarah Gilbertson et al.

   Messenger RNA degradation alters protein trafficking to control transcription.
5. 1. Chromosomes and Gene Expression

   The RNA interactome of human telomerase RNA reveals a coding-independent role for a histone mRNA in telomere homeostasis

   Roland Ivanyi-Nagy et al.
6. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   The Aquilegia genome provides insight into adaptive radiation and reveals an extraordinarily polymorphic chromosome with a unique history

   Danièle L Filiault et al.
7. 1. Chromosomes and Gene Expression
   2. Neuroscience

   Species and cell-type properties of classically defined human and rodent neurons and glia

   Xiao Xu et al.

   Gene expression and epigenetic profiling of defined cell types in the central nervous system of mouse, rat, and human reveals inter-species and inter-individual differences.
8. 1. Chromosomes and Gene Expression
   2. Developmental Biology

   Rif1 inhibits replication fork progression and controls DNA copy number in Drosophila

   Alexander Munden et al.

   To regulate DNA copy number during development in Drosophila, the SUUR protein recruits Rif1 to replisomes where Rif1 inhibits replication fork progression, thus controlling copy number independently of origin firing.
9. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   Yeast Ded1 promotes 48S translation pre-initiation complex assembly in an mRNA-specific and eIF4F-dependent manner

   Neha Gupta et al.

   Yeast RNA helicase Ded1 stimulates ribosome recruitment of structure-laden native mRNAs in a reconstituted system by interactions between domains in Ded1 and initiation factor eIF4G that stabilizes a Ded1-eIF4F complex.
10. 1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Intrinsic cooperativity potentiates parallel cis-regulatory evolution

    Trevor R Sorrells et al.

    Cooperativity between two transcription regulators occurs through protein-protein interactions with a general transcription factor complex and potentiates the parallel evolution of their DNA binding sites.