Chromosomes and Gene Expression

Chromosomes and Gene Expression

eLife reviews research ranging from transcription and RNA processing to epigenetics and chromatin biology. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    BRCA1/BRC-1 and SMC-5/6 regulate DNA repair pathway engagement during Caenorhabditis elegans meiosis

    Erik Toraason, Alina Salagean ... Diana E Libuda
    To maintain genomic integrity during oocyte development, the tumor suppressor BRCA1/BRC-1 and the SMC-5/6 complex both repress intersister crossover recombination events while BRCA1/BRC-1 also specifically inhibits error prone repair of DNA breaks during meiotic prophase I.
    1. Chromosomes and Gene Expression

    CyAbrB2 is a nucleoid-associated protein in Synechocystis controlling hydrogenase expression during fermentation

    Ryo Kariyazono, Takashi Osanai
    cyAbrB2, the global transcriptional factor conserved in cyanobacteria, is the nucleoid-associated protein, which is the first report in cyanobacteria.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Association with TFIIIC limits MYCN localisation in hubs of active promoters and chromatin accumulation of non-phosphorylated RNA polymerase II

    Raphael Vidal, Eoin Leen ... Gabriele Büchel
    MYCN and TFIIIC exert a censoring function during early transcription, limiting the accumulation of inactive RNAPII at the promoter and facilitating promoter-proximal degradation of nascent RNA.
    1. Chromosomes and Gene Expression
    2. Medicine

    LncRNA Snhg3 Aggravates Hepatic Steatosis via PPARγ Signaling

    Xianghong Xie, Mingyue Gao ... Xiaojun Liu
    1. Chromosomes and Gene Expression

    Target-specific requirements for RNA interference can arise through restricted RNA amplification despite the lack of specialized pathways

    Daphne R Knudsen-Palmer, Pravrutha Raman ... Antony M Jose
    Experimental results and computational modeling reveal many factors that influence if a gene can be efficiently silenced using RNA interference.
    1. Chromosomes and Gene Expression

    Artificially inserted strong promoter containing multiple G-quadruplexes induces long-range chromatin modification

    Shuvra Shekhar Roy, Sulochana Bagri ... Shantanu Chowdhury
    Non-duplex DNA structures induce distant chromatin-chromatin interactions and gene activation over long distances.

Senior editors

  1. Silke Hauf
    Virginia Tech, United States
  2. Adèle L Marston
    University of Edinburgh, United Kingdom
  3. K VijayRaghavan
    K VijayRaghavan
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, India
  4. See more editors