Chromosomes and Gene Expression

Chromosomes and Gene Expression

eLife reviews research ranging from transcription and RNA processing to epigenetics and chromatin biology. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Chromosomes and Gene Expression

    Control of meiotic entry by dual inhibition of a key mitotic transcription factor

    Amanda J. Su, Siri C. Yendluri, Elçin Ünal
    1. Chromosomes and Gene Expression

    Single molecule analysis of CENP-A chromatin by high-speed atomic force microscopy

    Daniël P Melters, Keir C Neuman ... Yamini Dalal
    A novel analytical workflow to quantitatively track motions of thousands of nucleosomes within chromatin fibers by high-speed atomic force microscopy.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1

    Maikel Castellano-Pozo, Georgios Sioutas ... Enrique Martinez-Perez
    Meiosis-specific cohesin complexes differing in their kleisin subunit display different chromosome binding dynamics and perform specialised functions in sister chromatid cohesion, chromosome axis organisation, and double-strand break repair.
    Short Report Updated
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    1. Chromosomes and Gene Expression
    2. Developmental Biology

    lncRNA read-through regulates the BX-C insulator Fub-1

    Airat Ibragimov, Xin Yang Bing ... Paul Schedl
    A novel mechanism of gene regulation is discovered wherein a specific long non-coding RNA abolishes the blocking activity of chromatin insulator in the Drosophila HOX gene cluster.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Gene Regulation: Blocking the blocker

    Qi Dai
    An unexpected interaction between a long non-coding RNA locus and a genetic insulator called Fub-1 has an important role in gene regulation during development in Drosophila.
    Insight
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    1. Cell Biology
    2. Chromosomes and Gene Expression

    The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recovery

    Yanqiu Li, Feifei Wang ... Aimin Peng
    The initiation of DNA damage checkpoint recovery involves ATM-mediated E3 ubiquitin ligase E6AP phosphorylation which disrupts E6AP-MASTL association and leads to MASTL protein accumulation and cell cycle resumption.

Senior editors

  1. Yamini Dalal
    National Cancer Institute, United States
  2. K VijayRaghavan
    K VijayRaghavan
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, India
  3. See more editors