Chromosomes and Gene Expression

Chromosomes and Gene Expression

eLife reviews research ranging from transcription and RNA processing to epigenetics and chromatin biology. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Degradation of LMO2 in T cell leukaemia results in collateral breakdown of transcription complex partners and causes LMO2-dependent apoptosis

    Naphannop Sereesongsaeng, Carole Bataille ... Terence Rabbitts
    Antibody surrogate degraders of LMO2 indicate that transcription complexes are susceptible to drug discovery and are therefore druggable.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins

    Roberta Carloni, Tadhg Devlin ... Robin C Allshire
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Role of ADMA-histones in dual-strand piRNA source loci recognition by Rhino

    Raku Saito, Hirotsugu Ishizu ... Mikiko C Siomi
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Dietary sulfur amino acid restriction elicits a cold-like transcriptional response in inguinal but not epididymal white adipose tissue of male mice

    Philip MM Ruppert, Aylin S Güller ... Jan-Wilhelm Kornfeld
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    High-throughput development and characterization of new functional nanobodies for gene regulation and epigenetic control in human cells

    Jun Wan, Abby R Thurm ... Lacramioara Bintu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Chromosomes and Gene Expression

    Decapping activators Edc3 and Scd6 act redundantly with Dhh1 in post-transcriptional repression of starvation-induced pathways

    Rakesh Kumar, Fan Zhang ... Alan G Hinnebusch
    Multi-omics analyses reveal redundant functions of yeast mRNA decapping activators Scd6 and Edc3 in facilitating recruitment of helicase Dhh1 and accelerating degradation of transcripts required for respiration in glucose-replete cells.
    1. Chromosomes and Gene Expression

    The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements

    Andria Koulle, Oluwaseun Ogundele ... Brian Hendrich
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Chromosomes and Gene Expression

    UV irradiation alters TFAM binding to mitochondrial DNA

    Dillon E King, Emily E Beard ... Joel N Meyer
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Inadequate
    1. Chromosomes and Gene Expression

    Interplay between cohesin and TORC1 links chromosome segregation and gene expression to environmental changes

    Dorian Besson, Sabine Vaur ... Jean-Paul Javerzat
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers

    Richard C Centore, Luis MM Soares ... Steven F Bellon
    Revised
    Reviewed Preprint v3
    Updated
    • Fundamental
    • Compelling
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Highlights

    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Navigating the secrets of COMPASS

    Karolin Luger, Jonathan W Markert
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Reality check for transposons

    Julie Brind'Amour, Dixie L Mager
    1. Chromosomes and Gene Expression

    Painting chromosomes in the nucleus

    Cori K Cahoon, Diana E Libuda

Senior editors

  1. Yamini Dalal
    National Cancer Institute, United States
  2. Adèle L Marston
    University of Edinburgh, United Kingdom
  3. Lori Sussel
    University of Colorado Anschutz Medical Campus, United States
  4. See more editors