Chromosomes and Gene Expression

Chromosomes and Gene Expression

eLife reviews research ranging from transcription and RNA processing to epigenetics and chromatin biology. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Chromosomes and Gene Expression
    2. Plant Biology

    Vernalization-triggered expression of the antisense transcript COOLAIR is mediated by CBF genes

    Myeongjune Jeon, Goowon Jeong ... Ilha Lee
    CBFs, the central regulators of low-temperature signaling, have a function to directly activate the expression of COOLAIR, an antisense RNA of FLC, during vernalization process, but COOLAIR is not required for the vernalization response.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Flowering: Keeping it cool

    Vy Nguyen, Iain Searle
    A well-established model for how plants start the process of flowering in periods of cold weather may need revisiting.
    Formats available:
    • HTML
    • PDF
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart

    Valeria Taliani, Giulia Buonaiuto ... Monica Ballarino
    The lncRNA pCharme controls the expression of cardiomyocyte maturation genes and heart development by orchestrating the formation of MATR3-enriched nuclear condensates.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    eRNA profiling uncovers the enhancer landscape of oesophageal adenocarcinoma and reveals new deregulated pathways

    Ibrahim Ahmed, Shen-Hsi Yang ... Andrew D Sharrocks
    eRNAs detected in patient-derived transcriptomic data can delineate potential active enhancer regions in oesophageal adenocarcinoma and uncover genes associated with the cancer phenotype.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Recruitment of Polo-like kinase couples synapsis to meiotic progression via inactivation of CHK-2

    Liangyu Zhang, Weston T Stauffer ... Abby F Dernburg
    Genetic and cytological analyses reveal a regulatory circuit that controls a key cell cycle transition during meiosis and mediates feedback regulation in response to meiotic defects.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    A transcriptome atlas of leg muscles from healthy human volunteers reveals molecular and cellular signatures associated with muscle location

    Tooba Abbassi-Daloii, Salma el Abdellaoui ... Vered Raz
    Molecular atlas of Human leg muscles molecular atlas reveals muscle-specific signatures that discriminate between muscle groups.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress

    Adwait A Godbole, Sneha Gopalan ... Amy K Walker
    Histone methylation patterns may differ depending on the enzymatic source of the methyl donor S-adenosylmethionine, suggesting the biological effects of low SAM may affect methylation targets in different ways, depending on the synthase producing it.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Synthetic analysis of chromatin tracing and live-cell imaging indicates pervasive spatial coupling between genes

    Christopher H Bohrer, Daniel R Larson
    The physical distance between genes in individual cells is the major factor driving co-transcriptional bursts, showing a significant degree of correlation for distances below 400 nm.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    RNA localization mechanisms transcend cell morphology

    Raeann Goering, Ankita Arora ... J Matthew Taliaferro
    Mechanisms that regulate RNA localization in one cell type predictably regulate RNA localization in other cell types, even if they have vastly different morphologies, implying an underlying regulatory code that cuts across specific subcellular structures.

Senior editors

  1. James Manley
    Columbia University, United States
  2. Kevin Struhl
    Harvard Medical School, United States
  3. K VijayRaghavan
    K VijayRaghavan
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, India
  4. See more editors