Chromosomes and Gene Expression

Latest articles

1. 1. Chromosomes and Gene Expression

   Cohesin architecture and clustering in vivo

   Siheng Xiang, Douglas Koshland

   Cohesin adopts a flexible butterfly conformation in vivo and forms spatial and temporal regulated ordered clusters to maintain cohesion and condensation.
2. 1. Chromosomes and Gene Expression
   2. Medicine

   Cardiovascular disease risk factors induce mesenchymal features and senescence in mouse cardiac endothelial cells

   Karthik Amudhala Hemanthakumar et al.
3. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   Archaeal chromatin 'slinkies' are inherently dynamic complexes with deflected DNA wrapping pathways

   Samuel Bowerman et al.
4. 1. Chromosomes and Gene Expression

   Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease

   Gang Wu et al.

   RNA profiles from lungs of mice exposed to intermittent hypoxia shared similarity with gene expression changes in human lung from patients with pulmonary diseases, including pulmonary hypertension, COPD, and asthma.
5. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Repressing Ago2 mRNA translation by Trim71 maintains pluripotency through inhibiting let-7 microRNAs

   Qiuying Liu et al.

   Repressing the conserved pro-differentiation let-7 microRNAs through limiting Ago2 levels is critical to maintaining pluripotency in stem cells.
6. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes

   Michelle C Ward et al.

   Cellular stress in a disease-relevant cell type uncovers novel genetic effects on gene expression, which is likely relevant for disease.
7. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   A nuclease- and bisulfite-based strategy captures strand-specific R-loops genome-wide

   Phillip Wulfridge, Kavitha Sarma

   BisMapR reveals strand-specific R-loops with high resolution at small-scale genomic features including bidirectionally transcribed promoters and enhancers.
8. 1. Cell Biology
   2. Chromosomes and Gene Expression

   DDK regulates replication initiation by controlling the multiplicity of Cdc45-GINS binding to Mcm2-7

   Lorraine De Jesus Kim et al.
9. 1. Chromosomes and Gene Expression
   2. Neuroscience

   Intronic enhancer region governs transcript-specific Bdnf expression in rodent neurons

   Jürgen Tuvikene et al.

   An evolutionarily conserved neuron-specific and stimulus-dependent enhancer region downstream of the Bdnf exon III regulates the expression of Bdnf transcripts starting from the upstream 5' exons.
10. 1. Chromosomes and Gene Expression
    2. Developmental Biology

    Foxc1 establishes enhancer accessibility for craniofacial cartilage differentiation

    Pengfei Xu et al.

    Foxc1 proteins prepare the genomes of neural crest-derived cells to facilitate their later development into the cartilages that support the embryonic face.