Chromosomes and Gene Expression

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   BET family members Bdf1/2 modulate global transcription initiation and elongation in Saccharomyces cerevisiae

   Rafal Donczew, Steven Hahn
2. 1. Chromosomes and Gene Expression
   2. Plant Biology

   Repression by the Arabidopsis TOPLESS corepressor requires association with the core mediator complex

   Alexander R Leydon et al.

   The TPL corepressor binds to the core mediator complex through MED21 to inhibit transcription while simultaneously priming repressed genes for rapid reactivation.
3. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Single-PanIN-seq unveils that ARID1A deficiency promotes pancreatic tumorigenesis by attenuating KRAS-induced senescence

   Shou Liu et al.

   ARID1A deficiency in SWI/SNF complex promotes pancreatic tumor development by upregulating ALDH protein levels to effectively reduce cellular reactive oxygen species levels, leading to the significant attenuation of oncogenic KRAS-induced senescence.
4. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Random sub-diffusion and capture of genes by the nuclear pore reduces dynamics and coordinates inter-chromosomal movement

   Michael Chas Sumner et al.

   Measuring and simulating chromatin dynamics reveals that repositioning of genes to the nuclear pore is neither active nor vectorial, but reduces sub-diffusion and coordinates movement between loci on different chromosomes.
5. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Cytoplasmic mRNA decay represses RNA polymerase II transcription during early apoptosis

   Christopher Duncan-Lewis et al.

   Human cells respond to cytoplasmic mRNA depletion during early apoptosis by inhibiting RNA polymerase II transcription, thereby magnifying the gene expression shutdown during stress.
6. 1. Cell Biology
   2. Chromosomes and Gene Expression

   HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics

   Amy R Strom et al.
7. 1. Chromosomes and Gene Expression

   RSC primes the quiescent genome for hypertranscription upon cell-cycle re-entry

   Christine E Cucinotta et al.

   Multiple mechanisms, by which a highly conserved chromatin-remodeling factor RSC facilitates initiation and maintenance of large-scale, rapid gene expression upon exit from quiescent state, have been discovered.
8. 1. Cell Biology
   2. Chromosomes and Gene Expression

   A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing

   Yu-Xuan Lu et al.

   Modulation of histone levels in gut enterocytes by rapamycin treatment alters chromatin organisation and induces intestinal autophagy through transcriptional regulation to prevent age-related decline in the intestine and extend lifespan.
9. 1. Chromosomes and Gene Expression

   miR-125-chinmo pathway regulates dietary restriction dependent enhancement of lifespan in Drosophila

   Manish Pandey et al.
10. 1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Epigenetic analysis of Paget’s disease of bone identifies differentially methylated loci that predict disease status

    Ilhame Diboun et al.

    PDB-associated differences in DNA methylation are reproducible and reflect key environmental modulators of bone homeostasis including viral processes, vitamin D metabolism, as well as mechanical sheer load.