Chromosomes and Gene Expression

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   ParB dynamics and the critical role of the CTD in DNA condensation unveiled by combined force-fluorescence measurements

   Julene Madariaga-Marcos et al.

   A single-molecule biophysical approach reveals that the C-terminal domain of ParB blocks ParB network formation by heterodimerization with the full-length protein, which remains bound to the DNA.
2. 1. Chromosomes and Gene Expression

   The RNA helicase UPF1 associates with mRNAs co-transcriptionally and is required for the release of mRNAs from gene loci

   Anand K Singh et al.
3. 1. Chromosomes and Gene Expression

   Dual control of NAD⁺ synthesis by purine metabolites in yeast

   Benoît Pinson et al.

   Two distinct processes drive coordinated synthesis of purine and pyridine (NAD⁺) nucleotides in response to AICAR derivatives and ATP.
4. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   Dissociation rate compensation mechanism for budding yeast pioneer transcription factors

   Benjamin T Donovan et al.
5. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Nuclear genetic regulation of the human mitochondrial transcriptome

   Aminah T Ali et al.

   Common nuclear genetic variants are associated with fundamental biological processes occurring in human mitochondria and potentially point to novel roles for nuclear genes in transcriptional regulation of the mitochondrial genome.
6. 1. Chromosomes and Gene Expression

   Multiple decay events target HAC1 mRNA during splicing to regulate the unfolded protein response

   Patrick D Cherry et al.
7. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   H3K9me3 is required for inheritance of small RNAs that target a unique subset of newly evolved genes

   Itamar Lev et al.

   In Caenorhabditis elegans histone methylation (H3K9me3) controls the synthesis of heritable small RNAs in a gene-specific manner and thus enables 'flagging' of newly-acquired genes.
8. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   PUMILIO hyperactivity drives premature aging of Norad-deficient mice

   Florian Kopp et al.

   Long noncoding RNA Norad performs an essential function in mammalian physiology by inhibiting the activity of PUMILIO RNA binding proteins, thereby suppressing a multi-system degenerative phenotype resembling premature aging.
9. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Noncoding RNA: Aging well with Norad

   Filipa Carvalhal Marques, Igor Ulitsky

   In mice, deleting a long noncoding RNA drives premature aging.
10. 1. Cell Biology
    2. Chromosomes and Gene Expression

    MYOD1 functions as a clock amplifier as well as a critical co-factor for downstream circadian gene expression in muscle

    Brian A Hodge et al.

    The myogenic lineage transcription factor, MYOD1, amplifies and works with the core clock factors to support a daily muscle gene expression program.