Chromosomes and Gene Expression

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   Competitive binding of MatP and topoisomerase IV to the MukB hinge domain

   Gemma LM Fisher et al.

   Topoisomerase IV and the ter-binding protein MatP competitively bind the hinge domain of the Escherichia coli Structural Maintenance of Chromosomes complex, MukB, leading to spatiotemporal regulation of MukBEF-topoisomerase IV activity.
2. 1. Chromosomes and Gene Expression
   2. Developmental Biology

   An XRCC4 mutant mouse, a model for human X4 syndrome, reveals interplays with Xlf, PAXX, and ATM in lymphoid development

   Benoit Roch et al.

   A viable separation of function XRCC4 knock-in mutant mouse model recapitulates some aspects of XRCC4 deficiency in humans, notably the absence of immune deficiency.
3. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   circFL-seq reveals full-length circular RNAs with rolling circular reverse transcription and nanopore sequencing

   Zelin Liu et al.
4. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   Pathway dynamics can delineate the sources of transcriptional noise in gene expression

   Lucy Ham et al.
5. 1. Cell Biology
   2. Chromosomes and Gene Expression

   microRNA-mediated regulation of microRNA machinery controls cell fate decisions

   Qiuying Liu et al.

   Genetic and biochemical analyses reveal that two stem-cell-specific microRNAs control stem cell fate decisions between pluripotency and differentiation through repressing Ago2, a key component of the microRNA machinery.
6. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   3′HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression

   Pamela Himadewi et al.

   The 3'HS1 CTCF binding site directly modulates chromosomal loops to regulate γ-globin expression through the accession of the hereditary persistence of fetal hemoglobin enhancer.
7. 1. Chromosomes and Gene Expression

   DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks

   Shalini Aricthota, Devyani Haldar
8. 1. Chromosomes and Gene Expression

   Phosphorylation of luminal region of the SUN-domain protein Mps3 promotes nuclear envelope localization during meiosis

   Hanumanthu BD Prasada Rao et al.
9. 1. Chromosomes and Gene Expression
   2. Evolutionary Biology

   Enhanced Cas12a multi-gene regulation using a CRISPR array separator

   Jens P Magnusson et al.

   Cas12a CRISPR arrays are sensitive to the GC content of their spacers, but AT-rich separator sequences successfully remove this disruptive effect and enable enhanced multiplexed gene targeting and activation.
10. 1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The interplay of RNA:DNA hybrid structure and G-quadruplexes determines the outcome of R-loop-replisome collisions

    Charanya Kumar et al.

    Reconstitution of orientation-specific R-loop-replisome collisions with purified proteins reveals the differential impact of R-loop-associated RNA:DNA hybrids and G-quadruplexes on replication fork progression.