Chromosomes and Gene Expression

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Non-invasive measurement of mRNA decay reveals translation initiation as the major determinant of mRNA stability

   Leon Y Chan et al.

   Non-invasive mRNA stability measurements reveal that transcript lifetime is governed by a competition with translation initiation on a transcriptome-wide level.
2. 1. Chromosomes and Gene Expression

   Condensin controls cellular RNA levels through the accurate segregation of chromosomes instead of directly regulating transcription

   Clémence Hocquet et al.
3. 1. Chromosomes and Gene Expression
   2. Plant Biology

   Arabidopsis RNA processing factor SERRATE regulates the transcription of intronless genes

   Corinna Speth et al.

   Arabidopsis RNA processing factor SERRATE associates with the chromatin of intronless genes, which are usually expressed at low levels, to enhance polymerase II association.
4. 1. Chromosomes and Gene Expression

   Six domesticated PiggyBac transposases together carry out programmed DNA elimination in Paramecium

   Julien Bischerour et al.

   The machinery that carries out programmed DNA rearrangements is composed of domesticated transposases. One is catalytically active, five play architectural function essential for the accuracy of the process.
5. 1. Chromosomes and Gene Expression
   2. Evolutionary Biology

   Intrinsic cooperativity potentiates parallel cis-regulatory evolution

   Trevor R Sorrells et al.
6. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   Defective RNA polymerase III is negatively regulated by the SUMO-Ubiquitin-Cdc48 pathway

   Zheng Wang et al.

   The SUMO-Ub-Cdc48 pathway is a novel regulatory mechanism of Pol III and a potential therapeutic target for Pol III-related human diseases.
7. 1. Chromosomes and Gene Expression
   2. Neuroscience

   Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells

   Mark F Sabbagh et al.

   Genome-wide integration of transcriptome, accessible chromatin, and DNA methylome data from vascular endothelial cells lays the foundation for understanding the gene regulatory circuits that generate organ-specific vascular specialization.
8. 1. Chromosomes and Gene Expression

   An asymmetric centromeric nucleosome

   Yuichi Ichikawa et al.

   Centromeric histones, the foundation for accurate chromosome segregation, have now been re-engineered to allow for analysis of the stoichiometry of required domains.
9. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   Structural basis for Scc3-dependent cohesin recruitment to chromatin

   Yan Li et al.

   The Cohesin subunit Scc3 contains a hook-shaped domain that binds to DNA substrate, thus revealing that Cohesin-chromatin transactions are driven not only by topological interactions, but also by direct protein-DNA contacts.
10. 1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome

    Ramasubramanian Sundaramoorthy et al.

    The unwrapping two turns of DNA on Chd1-bound nucleosomes cause the histone H3 tail and ubiquitin to be re-positioned.