Chromosomes and Gene Expression

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Neuroscience

   Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters

   Nikolai Petkau et al.

   Acetylation of the circadian transcription factor BMAL1 by the acetyltransferase TIP60 is crucial for recruitment of the pause release factors to clock gene promoters and productive elongation of these genes.
2. 1. Chromosomes and Gene Expression
   2. Developmental Biology

   Multi-enhancer transcriptional hubs confer phenotypic robustness

   Albert Tsai et al.

   Multiple enhancers in physical proximity can reinforce shared transcriptional 'hubs' to preserve their transcriptional output, providing a buffer during environmental stresses and genetic perturbations to preserve phenotypic robustness.
3. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Translational regulation of protrusion-localized RNAs involves silencing and clustering after transport

   Konstadinos Moissoglu et al.

   RNAs enriched at cell protrusions are translated regardless of their location in the cytoplasm but are dynamically repressed in retracting protrusions and incorporated into heterogeneous RNA clusters.
4. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Contractile acto-myosin network on nuclear envelope remnants positions human chromosomes for mitosis

   Alexander JR Booth et al.

   Live-cell imaging shows that the contractile acto-myosin network on the nuclear envelope remnant positions chromosomes in early mitosis to ensure efficient and correct interactions between chromosomes and the mitotic spindle.
5. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   Genetic interactions of G-quadruplexes in humans

   Katherine G Zyner et al.

   For the first time, the spectrum of genes and pathways interacting with alternative DNA structures called G-quadruplexes in humans is revealed highlighting new possibilities for the pursuit of cancer therapies.
6. 1. Chromosomes and Gene Expression
   2. Neuroscience

   Transgenerational inheritance of ethanol preference is caused by maternal NPF repression

   Julianna Bozler et al.

   Maternally experienced environmental stress leads to multigenerational inheritance of ethanol preference and an altered rewards pathway in Drosophila melanogaster.
7. 1. Chromosomes and Gene Expression

   Identification of RBPMS as a mammalian smooth muscle master splicing regulator via proximity of its gene with super-enhancers

   Erick E Nakagaki-Silva et al.

   By focusing on RNA-binding proteins whose genes have super enhancers in smooth muscle cells, the protein RBPMS was identified as an alternative splicing master regulator.
8. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome

   Jean Paul Armache et al.

   Cryo-EM structures capture different conformational states of chromatin remodeler-nucleosome complexes.
9. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Absolute quantification of cohesin, CTCF and their regulators in human cells

   Johann Holzmann et al.

   Absolute quantification of cohesin, CTCF, NIPBL, WAPL and sororin in HeLa cells implies that some genomic cohesin and CTCF enrichment sites are unoccupied at any one time.
10. 1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Improved CUT&RUN chromatin profiling tools

    Michael P Meers et al.

    Enhancements to the CUT&RUN antibody-targeted nuclease strategy for chromatin profiling include an improved affinity-cleavage fusion protein and digestion protocol, and a simplified calibration strategy.