Chromosomes and Gene Expression

Chromosomes and Gene Expression

eLife reviews research ranging from transcription and RNA processing to epigenetics and chromatin biology. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Chromosomes and Gene Expression

    TAD boundary architecture and gene activity are uncoupled

    Faisal Almansour, Nadezda A Fursova ... Tom Misteli
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Massively parallel reporter assay for mapping gene-specific regulatory regions at single-nucleotide resolution

    Alastair J Tulloch, Ryan Nicholas Delgado ... Constance L Cepko
    Integrated locus-specific and mutational MPRAs reveal regulatory modules and nucleotide determinants governing cell type-specific gene expression, providing a scalable framework for mapping cis-regulatory architecture.
    1. Chromosomes and Gene Expression

    UV irradiation alters TFAM binding specificity and compaction of DNA

    Dillon E King, Emily E Beard ... Joel N Meyer
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    • Convincing
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma

    Ariunaa Bayanjargal, Cenny Taslim ... Emily R Theisen
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Chromosomes and Gene Expression

    Acetylation of H3K115 is detected associated with fragile nucleosomes at CpG island promoters and active regulatory sites

    Yatendra Kumar, Dipta Sengupta ... Wendy A Bickmore
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Depletion of rRNA Methyltranferase METTL5 Enhances Anti-Tumor Immune Response via Neoantigen Generated from Cryptic Translation

    Yangyi Zhang, Xiaoyan Shi ... Hao Chen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    EPB41L4A-AS1 long noncoding RNA acts in both cis- and trans-acting transcriptional regulation and controls nucleolar biology

    Alan Monziani, Juan Pablo Unfried ... Igor Ulitsky
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Distinct chromatin regulators downmodulate meiotic axis protein deposition and DNA break induction at chromosome ends

    Adhithi R Raghavan, Kieron May ... Andreas Hochwagen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Chromosomes and Gene Expression

    Linking Germline Telomere Removal to Global Programmed DNA Elimination in Tetrahymena Genome Differentiation

    Kohei Nagao, Kazufumi Mochizuki
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Chromosomes and Gene Expression

    The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements

    Andria Koulle, Oluwaseun Ogundele ... Brian Hendrich
    CHD4 directly limits transcription factor binding to chromatin, which prevents activation of silent or cryptic enhancers but facilitates activity of active enhancers.
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Highlights

    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Navigating the secrets of COMPASS

    Karolin Luger, Jonathan W Markert
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Reality check for transposons

    Julie Brind'Amour, Dixie L Mager
    1. Chromosomes and Gene Expression

    Painting chromosomes in the nucleus

    Cori K Cahoon, Diana E Libuda

Senior editors

  1. Yamini Dalal
    National Cancer Institute, United States
  2. Adèle L Marston
    University of Edinburgh, United Kingdom
  3. Lori Sussel
    University of Colorado Anschutz Medical Campus, United States
  4. See more editors