Chromosomes and Gene Expression

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Developmental Biology and Stem Cells

   SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program

   Madara Ratnadiwakara et al.

   RNA-binding protein SRSF3 mediates critical changes in RNA processing of pluripotency genes, which reveals functional consequences of regulated RNA processing during stem cell self-renewal and early development.
2. 1. Chromosomes and Gene Expression

   Chromatin-associated RNA sequencing (ChAR-seq) maps genome-wide RNA-to-DNA contacts

   Jason C Bell et al.

   ChAR-seq is a massively parallelized de novo RNA mapping assay, which is capable of generating hundreds to thousands of RNA-binding maps with no a priori knowledge of target RNAs.
3. 1. Chromosomes and Gene Expression
   2. Developmental Biology and Stem Cells

   G9a regulates temporal preimplantation developmental program and lineage segregation in blastocyst

   Jan J Zylicz et al.

   Loss of a maternally inherited epigenetic modifier leads to establishment of an aberrant regulatory network in preimplantation embryos, developmental delay and destabilisation of cell-fate choices.
4. 1. Cell Biology
   2. Chromosomes and Gene Expression

   A conserved function for pericentromeric satellite DNA

   Madhav Jagannathan et al.

   Satellite DNA mediates clustering of multiple chromosomes via formation of chromocenter to encapsulate the full complement of the genome into a single nucleus.
5. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria

   Minxian Qian et al.

   The ATM-SIRT6 axis integrates the DNA repair machinery to longevity-promoting pathways.
6. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Chromocenters: Bundling up DNA

   Susan A Gerbi

   Structures known as chromocenters, comprising satellite DNA and proteins such as D1 or HMGA1, help to contain DNA inside the nucleus between cell divisions.
7. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   The conformation of the histone H3 tail inhibits association of the BPTF PHD finger with the nucleosome

   Emma A Morrison et al.

   The BPTF PHD finger is inhibited from binding the methylated H3 tails in the context of the nucleosome due to their robust interaction with the nucleosomal DNA, which can be modulated by additional histone PTMs.
8. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   Computational prediction of CTCF/cohesin-based intra-TAD loops that insulate chromatin contacts and gene expression in mouse liver

   Bryan J Matthews, David J Waxman
9. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Rev7 and 53BP1/Crb2 prevent RecQ helicase-dependent hyper-resection of DNA double-strand breaks

   Bryan A Leland et al.

   A single-cell assay reveals that the genetic rewiring that underlies PARP inhibitor resistance drives altered DNA double-strand break end resection pathway choice.
10. 1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Human LINE-1 retrotransposition requires a metastable coiled coil and a positively charged N-terminus in L1ORF1p

    Elena Khazina, Oliver Weichenrieder

    Human LINE-1 retrotransposition is found to critically depend on the rapidly evolving N-terminal sequence of the LINE-1 ORF1 protein and on the metastability of its coiled coil domain, indicating uncharacterized steps in LINE-1 retrotransposition.