Chromosomes and Gene Expression

Chromosomes and Gene Expression

eLife publishes research ranging from transcription and RNA processing to epigenetics and chromatin biology. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A prion accelerates proliferation at the expense of lifespan

    David M Garcia et al.
    In its capacity to switch into a heritable, prionogenic form, a conserved RNA-modifying enzyme epigenetically alters fundamental growth, aging, and protein synthesis properties of eukaryotic cells.
    1. Chromosomes and Gene Expression

    SUV39 SET domains mediate crosstalk of heterochromatic histone marks

    Alessandro Stirpe et al.
    Clr4, a highly conserved SUV39 histone methyltransferase, requires its SET domain to sense histone H3K14 ubiquitination in order to maintain heterochromatin and H3K9 methylation.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    A nascent polypeptide sequence modulates DnaA translation elongation in response to nutrient availability

    Michele Felletti et al.
    Specific amino acids in the N-terminus of the replication initiator protein DnaA inhibit translation elongation upon carbon starvation, illustrating that the identity of the N-terminal amino acids of a protein can modulate protein synthesis yield under changing conditions.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A precisely adjustable, variation-suppressed eukaryotic transcriptional controller to enable genetic discovery

    Asli Azizoglu et al.
    A new gene expression tool enables precise control of protein dosage over a large range and paves the way for new genetic discoveries.
    1. Chromosomes and Gene Expression

    Linker histone H1.8 inhibits chromatin binding of condensins and DNA topoisomerase II to tune chromosome length and individualization

    Pavan Choppakatla et al.
    Linker histone H1.8 shapes mitotic chromosomes by tuning the number and size of condensin-dependent DNA loops and suppressing condensin and DNA topoisomerase II-dependent individualization.

Senior editors

  1. Matt Kaeberlein
    University of Washington, United States
  2. James Manley
    Columbia University, United States
  3. Jessica Tyler
    Weill Cornell Medicine, United States
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