Chromosomes and Gene Expression

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Cis-regulatory basis of sister cell type divergence in the vertebrate retina

   Daniel P Murphy et al.

   While photoreceptor and bipolar cells exhibit very similar cis-regulatory grammars, subtle differences in homeodomain motif enrichment represent a key distinction driving the divergence in their transcriptomes.
2. 1. Chromosomes and Gene Expression
   2. Evolutionary Biology

   Dynamic turnover of centromeres drives karyotype evolution in Drosophila

   Ryan Bracewell et al.

   De novo formation of centromeres creates diverse karyotypes in flies and is accompanied by rapid turnover of centromere-associated satellite repeats.
3. 1. Cell Biology
   2. Chromosomes and Gene Expression

   H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis

   Andrey Poleshko et al.

   The histone modification H3K9me2 marks peripheral heterochromatin and ensures positional information is safeguarded through cell division such that individual lamina-associated domains are re-established at the nuclear periphery in daughter nuclei.
4. 1. Chromosomes and Gene Expression

   Epigenetic memory independent of symmetric histone inheritance

   Daniel S Saxton, Jasper Rine
5. 1. Chromosomes and Gene Expression

   Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer

   Jennifer Munkley et al.

   The male steroid hormone testosterone regulates splicing patterns by controlling the expression of a key splicing regulator protein.
6. 1. Chromosomes and Gene Expression

   CTCF confers local nucleosome resiliency after DNA replication and during mitosis

   Nick Owens et al.
7. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS

   Mary McMahon et al.

   Cancer-associated changes in small nucleolar RNAs and site-specific pseudouridine modifications impact ribosome activity.
8. 1. Chromosomes and Gene Expression

   TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

   Remi Sonneville et al.

   The TRAIP ubiquitin ligase is required during mitosis to disassemble the replisome at sites of incomplete DNA replication, and activate the mitotic DNA repair pathway, thus preserving genome integrity.
9. 1. Chromosomes and Gene Expression

   The tardigrade damage suppressor protein binds to nucleosomes and protects DNA from hydroxyl radicals

   Carolina Chavez et al.

   Dsup, a unique protein found only in tardigrades, is a nucleosome-binding protein that protects DNA from damage by hydroxyl radicals, such as those generated by ionizing radiation or oxidants.
10. 1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Viral miRNA adaptor differentially recruits miRNAs to target mRNAs through alternative base-pairing

    Carlos Gorbea et al.

    iRICC, a new method to identify RNA-RNA interactions in vivo, provides mechanistic insight into the function of a viral non-coding RNA.