Chromosomes and Gene Expression

Chromosomes and Gene Expression

eLife reviews research ranging from transcription and RNA processing to epigenetics and chromatin biology. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cell Biology
    2. Chromosomes and Gene Expression

    Heat stress impairs centromere structure and segregation of meiotic chromosomes in Arabidopsis

    Lucie Crhak Khaitova, Pavlina Mikulkova ... Karel Riha
    The sensitivity of Arabidopsis meiotic centromeres to heat stress suggests that centromere function is one of the key determinants of plant reproduction under rising temperatures.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    N-Terminus of Drosophila Melanogaster MSL1 Is Critical for Dosage Compensation

    Valentin Babosha, Natalia Klimenko ... Oksana Maksimenko
    1. Chromosomes and Gene Expression

    Post-transcriptional splicing can occur in a slow-moving zone around the gene

    Allison Coté, Aoife O'Farrell ... Arjun Raj
    The existence of a slow-moving zone around the transcription site may unify conflicting models of co-transcriptional versus post-transcriptional mRNA splicing.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Single-cell ‘omic profiles of human aortic endothelial cells in vitro and human atherosclerotic lesions ex vivo reveal heterogeneity of endothelial subtype and response to activating perturbations

    Maria L Adelus, Jiacheng Ding ... Casey E Romanoski
    Primary endothelial cell cultures contain markedly heterogeneous cell subtypes that exhibit distinct molecular responses to disease-relevant exposures.
    1. Chromosomes and Gene Expression

    Transcriptome-wide analysis of the function of Ded1 in translation preinitiation complex assembly in a reconstituted in vitro system

    Fujun Zhou, Julie M Bocetti ... Jon R Lorsch
    A new in vitro approach allows measurement of the efficiency of the early steps of translation initiation on every messenger RNA in yeast simultaneously.
    1. Chromosomes and Gene Expression

    Integrative analysis of DNA replication origins and ORC-/MCM-binding sites in human cells reveals a lack of overlap

    Mengxue Tian, Zhenjia Wang ... Chongzhi Zang
    The ~20,000 origins of replication in human cell lines that are reproducibly identified by multiple techniques in multiple cell lines are distant from known origin recognition complex and MCM2-7-binding sites.
    1. Chromosomes and Gene Expression

    A concerted increase in readthrough and intron retention drives transposon expression during aging and senescence

    Kamil Pabis, Diogo Barardo ... Brian K Kennedy
    A majority of transcribed transposons during aging are derived from transcriptional defects, most notably intron retention and transcriptional readthrough.

Senior editors

  1. Yamini Dalal
    National Cancer Institute, United States
  2. Lori Sussel
    University of Colorado Anschutz Medical Campus, United States
  3. K VijayRaghavan
    K VijayRaghavan
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, India
  4. See more editors