Chromosomes and Gene Expression

Latest articles

1. 1. Chromosomes and Gene Expression

   Histone H3 threonine 11 phosphorylation by Sch9 and CK2 regulates chronological lifespan by controlling the nutritional stress response

   Seunghee Oh et al.

   Histone H3T11 phosphorylation regulates chronological lifespan by linking nutritional stress-response signals to chromatin.
2. 1. Chromosomes and Gene Expression
   2. Human Biology and Medicine

   A promoter interaction map for cardiovascular disease genetics

   Lindsey E Montefiori et al.
3. 1. Chromosomes and Gene Expression

   A stable mode of bookmarking by TBP recruits RNA polymerase II to mitotic chromosomes

   Sheila S Teves et al.

   The general transcriptional machinery promotes the efficient reactivation of global transcription following mitosis, and thereby enables maintenance of transcriptional memory through the cell cycle.
4. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   Rad52-Rad51 association is essential to protect Rad51 filaments against Srs2, but facultative for filament formation

   Emilie Ma et al.
5. 1. Chromosomes and Gene Expression

   PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading

   Gergely Rona et al.

   Upon genotoxic stress, the FBXL10-RNF68-RNF2 ubiquitin ligase complex mono-ubiquitylates histone H2A and mediates H2A/H2A.Z exchange to repress transcription and ensures proper high fidelity homologous recombination repair.
6. 1. Chromosomes and Gene Expression
   2. Immunology and Inflammation

   ZFP36 RNA-binding proteins restrain T cell activation and anti-viral immunity

   Michael J Moore et al.

   By attenuating the translation of key mRNA targets, ZFP36 RNA binding proteins restrain the expansion and effector activity of T cells.
7. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   TASEP modelling provides a parsimonious explanation for the ability of a single uORF to derepress translation during the integrated stress response

   Dmitry E Andreev et al.

   A model reveals how translation of an mRNA leader could provide resistance to global downregulation of translation.
8. 1. Chromosomes and Gene Expression

   H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers

   Dong Fang et al.

   Redistribution of the PRC2 complex in H3.3K27M mutant cells to poised enhancers contributes to the global reduction of H3K27me3 in cells expressing the mutant proteins.
9. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   The eukaryotic bell-shaped temporal rate of DNA replication origin firing emanates from a balance between origin activation and passivation

   Jean-Michel Arbona et al.

   The universal eukaryotic DNA replication kinetics is the consequence of simple physicochemical rules resulting from the localisation of potential replication origins at discrete sites and the diffusion of limiting origin firing factors in the nuclear space.
10. 1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    A twist defect mechanism for ATP-dependent translocation of nucleosomal DNA

    Jessica Winger et al.

    Based on its nucleotide-bound state, the Chd1 chromatin remodeler can locally alter DNA twist on the nucleosome, which either pulls in or expels ~1 bp of DNA at the internal SHL2 binding site.