Chromosomes and Gene Expression

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Microbiology and Infectious Disease

   Single-cell RNA-seq reveals trans-sialidase-like superfamily gene expression heterogeneity in Trypanosoma cruzi populations

   Lucas Inchausti, Lucia Bilbao ... Pablo Smircich

   Transcriptomic heterogeneity in infective-stage surface proteins of Trypanosoma cruzi, particularly trans-sialidase-like superfamily members, suggests distinct expression profiles among individual parasites that may enhance immune evasion and infection adaptability.
2. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   DNA O-MAP uncovers the molecular neighborhoods associated with specific genomic loci

   Yuzhen Liu, Christopher D McGann ... Devin K Schweppe

   DNA O-MAP enables proximity labeling at specific genomic loci in fixed cells using programmable oligonucleotides, revealing locus-proximal proteomes and chromatin interactions without genetic modification.
3. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   Evidence of off-target probe binding affecting 10x Genomics Xenium gene panels compromise accuracy of spatial transcriptomic profiling

   Caleb Hallinan, Hyun Joo Ji ... Jean Fan
4. 1. Chromosomes and Gene Expression

   Interplay between cohesin and TORC1 links chromosome segregation and gene expression to environmental changes

   Dorian Besson, Sabine Vaur ... Jean-Paul Javerzat
5. 1. Chromosomes and Gene Expression

   TAD boundaries and gene activity are uncoupled

   Faisal Almansour, Nadezda A Fursova ... Tom Misteli
6. 1. Chromosomes and Gene Expression
   2. Medicine

   Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model

   Fangluo Chen, Muzna Saqib ... G William Wong
7. 1. Chromosomes and Gene Expression

   UV irradiation alters TFAM binding specificity and compaction of DNA

   Dillon E King, Emily E Beard ... Joel Meyer

   Independent experimental approaches demonstrate changes in TFAM binding to UVC-irradiated DNA, providing a potential mechanism for DNA damage sensing in the mitochondria.
8. 1. Chromosomes and Gene Expression

   Single Domain Antibody Inhibitors Target the Coiled Coil Arms of the Bacillus subtilis SMC complex

   Ophélie Gosselin, Michael Taschner ... Stephan Gruber
9. 1. Chromosomes and Gene Expression
   2. Microbiology and Infectious Disease

   Epigenetics and chromatin structure regulate var2csa expression and the placental binding phenotype in Plasmodium falciparum

   Todd Lenz, Madle Sirel ... Ulf Ribacke
10. 1. Cell Biology
    2. Chromosomes and Gene Expression

    Dynamic RNA Polymerase compartments organize the transcription of gene clusters

    Yi-Hui Wang, Hannah L Hertz, Wen Tang