Chromosomes and Gene Expression

Chromosomes and Gene Expression

eLife reviews research ranging from transcription and RNA processing to epigenetics and chromatin biology. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cell Biology
    2. Chromosomes and Gene Expression

    LSD1 defines the fiber type-selective responsiveness to environmental stress in skeletal muscle

    Hirotaka Araki, Shinjiro Hino ... Mitsuyoshi Nakao
    Lysine-specific demethylase-1 acts as an epigenetic barrier against glucocorticoid-induced atrophy and exercise-induced hypertrophy in skeletal muscle.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8

    Nan Wang, Jing He ... Kehkooi Kee
    The lncRNA landscapes in human germ cells are comprehensively profiled and the functional role of an lncRNA LNC1845 in regulating gene expression of a neighboring coding gene LHX8 is elucidated.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    STAT3 promotes RNA polymerase III-directed transcription by controlling the miR-106a-5p/TP73 axis

    Cheng Zhang, Shasha Zhao ... Wensheng Deng
    The miR-106a-5p links STAT3 with TP73 to activate Pol III-dependent transcription and cancer cell proliferative activity.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Promoter sequence and architecture determine expression variability and confer robustness to genetic variants

    Hjörleifur Einarsson, Marco Salvatore ... Robin Andersson
    A flexible transcription initiation architecture and a uniform regulatory grammar buffer expression variability and the effects of genetic variants on essential genes while a rigid transcription initiation architecture and a diverse regulatory grammar ensure condition-specific responsiveness of other genes.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Maternal obesity blunts antimicrobial responses in fetal monocytes

    Suhas Sureshchandra, Brianna M Doratt ... Ilhem Messaoudi
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Transcriptional profiling of Hutchinson-Gilford Progeria syndrome fibroblasts reveals deficits in mesenchymal stem cell commitment to differentiation related to early events in endochondral ossification

    Rebeca San Martin, Priyojit Das ... Rachel Patton McCord
    Age-stratified comparisons of gene expression in progeria patient fibroblasts reveals disruption of mesenchymal lineage pathways and points to a deficit in chondrogenic commitment in early development and a depletion of the mesenchymal lineage stem cell pool.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Inducible lncRNA transgenic mice reveal continual role of HOTAIR in promoting breast cancer metastasis

    Qing Ma, Liuyi Yang ... Howard Y Chang
    HOTAIR is required in an ongoing manner when it regulates epigenetic status and reprograms cancer cell gene expression in promoting breast cancer metastasis.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Adaptation to glucose starvation is associated with molecular reorganization of the circadian clock in Neurospora crassa

    Anita Szőke, Orsolya Sárkány ... Krisztina Káldi
    Molecular timekeeping in Neurospora crassa is robust even under severe limitation of carbon sources and the efficient adaptation to changing nutrient availability is dependent on the positive component of the circadian clock.

Senior editors

  1. James Manley
    Columbia University, United States
  2. Kevin Struhl
    Harvard Medical School, United States
  3. K VijayRaghavan
    K VijayRaghavan
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, India
  4. See more editors