Chromosomes and Gene Expression

Chromosomes and Gene Expression

eLife publishes research ranging from transcription and RNA processing to epigenetics and chromatin biology. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    ATP binding facilitates target search of SWR1 chromatin remodeler by promoting one-dimensional diffusion on DNA

    Claudia C Carcamo et al.
    In vitro single-particle tracking reveals that ATP binding increases the one-dimensional diffusion of yeast chromatin remodeler SWR1 on DNA stretched between optical tweezers and diffusion is confined by protein roadblocks and nucleosomes.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Polysome-CAGE of TCL1-driven chronic lymphocytic leukemia revealed multiple N-terminally altered epigenetic regulators and a translation stress signature

    Ariel Ogran et al.
    Examination of the changes in the transcription start site selection in TCL1-driven chronic lymphocytic leukemia and their impact on mRNA translation revealed a marked elevation of intra-genic cryptic promoters, which are predicted to generate multiple N-terminally truncated or modified proteins.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Hematopoietic plasticity mapped in Drosophila and other insects

    Dan Hultmark, István Andó
    A critical analysis of recent single-cell transcriptomic studies of Drosophila blood cells confirms the extreme plasticity of the major phagocyte class, identifies a new class of blood cell, and suggests relationships to blood cells in other insects.
    1. Chromosomes and Gene Expression

    Genetic dissection of the RNA polymerase II transcription cycle

    Shao-Pei Chou et al.
    Natural genetic variation reveals how DNA sequence impacts core transcriptional processes of initiation, pause, and termination.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Rapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons

    Lewis Macdonald et al.
    Auxin-inducible degradation of CRISPR-tagged endogenous proteins in mice reveals cell-type-specific dependence on the mitotic chromosome condensation proteins.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    On demand expression control of endogenous genes with DExCon, DExogron and LUXon reveals differential dynamics of Rab11 family members

    Jakub Gemperle et al.
    DExCon, LUXon, and DExogron approaches simultaneously block endogenous gene expression and permit tuning of re-expression levels in time and space; proof-of-principle reveals unforeseen differences in protein kinetics, cargo handling, and cell migration regulation between closely related Rab11 family members.
    1. Chromosomes and Gene Expression

    Dynamic spreading of chromatin-mediated gene silencing and reactivation between neighboring genes in single cells

    Sarah Lensch et al.
    In a synthetic system, spreading of chromatin-mediated silencing to nearby genes depends on distance and can bypass genetic insulators, while reactivation after release of gene targeting is coordinated by insulators and promoters.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance

    Eriko Matsuura-Suzuki et al.
    METTL18 methylates histidine 245 of ribosomal protein RPL3, retards ribosome traversal at tyrosine codons, and thus ensures nascent protein folding for proteostasis maintenance.

Senior editors

  1. James Manley
    Columbia University, United States
  2. Kevin Struhl
    Harvard Medical School, United States
  3. K VijayRaghavan
    K VijayRaghavan
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, India
  4. See more editors