Chromosomes and Gene Expression

Chromosomes and Gene Expression

eLife publishes research ranging from transcription and RNA processing to epigenetics and chromatin biology. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    High rates of evolution preceded shifts to sex-biased gene expression in Leucadendron, the most sexually dimorphic angiosperms

    Mathias Scharmann et al.
    In the dioecious plant genus Leucadendron, shifts to sex-biased gene expression occurred predominantly in genes with ancestrally high rates of expression evolution, and were not correlated with morphology.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts

    Calvin Jon A Leonen et al.
    Chemically sumoylated histone H4 shows negative biochemical crosstalk with gene-activating histone acetylation and methylation marks, and directly inhibits RNA polymerase II-mediated gene transcription.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Pathway dynamics can delineate the sources of transcriptional noise in gene expression

    Lucy Ham et al.
    There are fundamental limits to what can be learned about the origins of transcriptional noise from gene expression data alone, which can be overcome by simultaneously quantifying the abundances of linked molecular species.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Local chromatin fiber folding represses transcription and loop extrusion in quiescent cells

    Sarah G Swygert et al.
    Using a yeast model of quiescence, it was demonstrated that dramatic changes in local chromatin fiber folding can occur under physiological conditions to regulate cellular processes.
    1. Chromosomes and Gene Expression

    Phosphorylation of luminal region of the SUN-domain protein Mps3 promotes nuclear envelope localization during meiosis

    Hanumanthu BD Prasada Rao et al.
    Cytological analyses combined with in vitro liposome reconstitution reveal that yeast SUN domain protein, Mps3, shows meiosis-specific phosphorylation in the luminal region of the nuclear envelope during meiosis for chromosome motion and nuclear envelope remodelling.
    1. Chromosomes and Gene Expression

    DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks

    Shalini Aricthota, Devyani Haldar
    Sirtuin, Hst4 is a novel DDK kinase target, which is modified and degraded in response to replication stress, increasing H3K56 acetylation, to stabilize DNA replication forks via fork protection complex which maintains genome stability and has potential in cancer therapeutics.
    1. Chromosomes and Gene Expression
    2. Medicine

    Disrupted PGR-B and ESR1 signaling underlies defective decidualization linked to severe preeclampsia

    Tamara Garrido-Gomez et al.
    The in vivo transcriptomic fingerprint encoding defective decidualization comprises 120 genes associated with an imbalance hormonal signaling in the decidual endometria of women who developed severe preeclampsia.

Senior editors

  1. Kevin Struhl
    Harvard Medical School, United States
  2. Jessica Tyler
    Weill Cornell Medicine, United States
  3. K VijayRaghavan
    K VijayRaghavan
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, India
  4. See more editors