Chromosomes and Gene Expression

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Heterochromatin-dependent transcription of satellite DNAs in the Drosophila melanogaster female germline

   Xiaolu Wei et al.

   The piRNA pathway regulates satellite DNAs in the Drosophila melanogaster germline and affects heterochromatin establishment at pericentromeric satellite DNA in embryos, implying a general role for piRNAs in ensuring genome stability.
2. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   Analysis of the PcrA-RNA polymerase complex reveals a helicase interaction motif and a role for PcrA/UvrD helicase in the suppression of R-loops

   Inigo Urrutia-Irazabal et al.

   RNA polymerase recruits the PcrA DNA helicase via a conserved interaction motif in order to remove R-loops and prevent conflicts with replication.
3. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Non-canonical H3K79me2-dependent pathways promote the survival of MLL-rearranged leukemia

   William F Richter et al.

   FLT3-ITD/STAT5A signaling is more sensitive to Dot1L inhibition than the canonical MLL-fusion activated drivers of leukemogenesis, providing a potential therapeutic avenue for one of the most frequent lesions in leukemia.
4. 1. Chromosomes and Gene Expression

   Single-molecule imaging of chromatin remodelers reveals role of ATPase in promoting fast kinetics of target search and dissociation from chromatin

   Jee Min Kim et al.
5. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   In vivo analysis reveals that ATP-hydrolysis couples remodeling to SWI/SNF release from chromatin

   Ben Tilly et al.
6. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   Genome Organization: The loopy world of cohesin

   Kazuhiro Maeshima, Shiori Iida

   DNA loops can be formed by a mechanism in which the cohesin complex pulls DNA strands through its ring structure using biased Brownian motion.
7. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways

   Ryo Miyamoto et al.

   HOXA9 is a transcriptional maintenance factor for anti-apoptotic genes that accelerate MYC-driven leukemia.
8. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   A Brownian ratchet model for DNA loop extrusion by the cohesin complex

   Torahiko L Higashi et al.

   A structure-based model of the chromosomal cohesin complex, accompanied by molecular-mechanistic simulations, explains cohesin's key role in topologically entrapping DNA, as well as its ability to alternatively extrude DNA loops.
9. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Cdc4 phospho-degrons allow differential regulation of Ame1^CENP-U protein stability across the cell cycle

   Miriam Böhm et al.
10. 1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    CTP promotes efficient ParB-dependent DNA condensation by facilitating one-dimensional diffusion from parS

    Francisco de Asis Balaguer et al.

    Single-molecule methods reveal that cytidine triphosphate promotes DNA condensation specifically at bacterial centromeres by facilitating one-dimensional diffusion of ParB from parS sites.