Chromosomes and Gene Expression

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility

   Fernanda M Bosada, Karel van Duijvenboden ... Vincent M Christoffels
2. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Recruitment of Polo-like kinase couples synapsis to meiotic progression via inactivation of CHK-2

   Liangyu Zhang, Weston T Stauffer ... Abby F Dernburg
3. 1. Cell Biology
   2. Chromosomes and Gene Expression

   LSD1 defines the fiber type-selective responsiveness to environmental stress in skeletal muscle

   Hirotaka Araki, Shinjiro Hino ... Mitsuyoshi Nakao

   Lysine-specific demethylase-1 acts as an epigenetic barrier against glucocorticoid-induced atrophy and exercise-induced hypertrophy in skeletal muscle.
4. 1. Chromosomes and Gene Expression
   2. Developmental Biology

   Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8

   Nan Wang, Jing He ... Kehkooi Kee

   The lncRNA landscapes in human germ cells are comprehensively profiled and the functional role of an lncRNA LNC1845 in regulating gene expression of a neighboring coding gene LHX8 is elucidated.
5. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   STAT3 promotes RNA polymerase III-directed transcription by controlling the miR-106a-5p/TP73 axis

   Cheng Zhang, Shasha Zhao ... Wensheng Deng

   The miR-106a-5p links STAT3 with TP73 to activate Pol III-dependent transcription and cancer cell proliferative activity.
6. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   Promoter sequence and architecture determine expression variability and confer robustness to genetic variants

   Hjörleifur Einarsson, Marco Salvatore ... Robin Andersson

   A flexible transcription initiation architecture and a uniform regulatory grammar buffer expression variability and the effects of genetic variants on essential genes while a rigid transcription initiation architecture and a diverse regulatory grammar ensure condition-specific responsiveness of other genes.
7. 1. Chromosomes and Gene Expression
   2. Immunology and Inflammation

   Maternal obesity blunts antimicrobial responses in fetal monocytes

   Suhas Sureshchandra, Brianna M Doratt ... Ilhem Messaoudi
8. 1. Chromosomes and Gene Expression
   2. Developmental Biology

   Transcriptional profiling of Hutchinson-Gilford Progeria syndrome fibroblasts reveals deficits in mesenchymal stem cell commitment to differentiation related to early events in endochondral ossification

   Rebeca San Martin, Priyojit Das ... Rachel Patton McCord

   Age-stratified comparisons of gene expression in progeria patient fibroblasts reveals disruption of mesenchymal lineage pathways and points to a deficit in chondrogenic commitment in early development and a depletion of the mesenchymal lineage stem cell pool.
9. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Inducible lncRNA transgenic mice reveal continual role of HOTAIR in promoting breast cancer metastasis

   Qing Ma, Liuyi Yang ... Howard Y Chang

   HOTAIR is required in an ongoing manner when it regulates epigenetic status and reprograms cancer cell gene expression in promoting breast cancer metastasis.
10. 1. Cell Biology
    2. Chromosomes and Gene Expression

    Adaptation to glucose starvation is associated with molecular reorganization of the circadian clock in Neurospora crassa

    Anita Szőke, Orsolya Sárkány ... Krisztina Káldi

    Molecular timekeeping in Neurospora crassa is robust even under severe limitation of carbon sources and the efficient adaptation to changing nutrient availability is dependent on the positive component of the circadian clock.