Chromosomes and Gene Expression

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Biochemistry and Chemical Biology

   Cooperative interactions facilitate stimulation of Rad51 by the Swi5-Sfr1 auxiliary factor complex

   Bilge Argunhan et al.

   The intrinsically disordered N-terminus of Sfr1 contains two Rad51 binding sites that facilitate Rad51 filament stabilization and ATPase stimulation by the Swi5-Sfr1 complex, leading to efficient Rad51-driven strand exchange.
2. 1. Chromosomes and Gene Expression

   Stop codon context influences genome-wide stimulation of termination codon readthrough by aminoglycosides

   Jamie R Wangen, Rachel Green

   Ribosome profiling reveals genome-wide stimulation of stop codon readthrough by aminoglycosides that is influenced sequence context.
3. 1. Chromosomes and Gene Expression

   Translation: Finding sense in the context

   Kim M Keeling, David M Bedwell

   Ribosomal profiling has shed new light on how ribosomes can ignore stop codons in messenger RNA.
4. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   An H3K9 methylation dependent protein interaction regulates the non-enzymatic function of a putative histone demethylase

   Gulzhan Raiymbek et al.
5. 1. Chromosomes and Gene Expression

   Monoubiquitination by the human Fanconi Anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays

   Winnie Tan et al.
6. 1. Chromosomes and Gene Expression
   2. Neuroscience

   Losing Dnmt3a dependent methylation in inhibitory neurons impairs neural function by a mechanism impacting Rett syndrome

   Laura A Lavery et al.

   Dnmt3a regulates gene expression in inhibitory neurons by writing all mCH and some mCG, and MeCP2 reads some of these mCH sites driving a portion of these gene expression changes.
7. 1. Chromosomes and Gene Expression

   PHF19 mediated regulation of proliferation and invasiveness in prostate cancer cells

   Payal Jain et al.

   Depletion of PHF19 in prostate cancer cells leads to an increase in MTF2 and PRC2 chromatin occupancy causing deregulation of key genes critical for proliferation and metastasis.
8. 1. Chromosomes and Gene Expression
   2. Immunology and Inflammation

   Polypyrimidine tract-binding proteins are essential for B cell development

   Elisa Monzón-Casanova et al.

   The RNA-binding protein polypyrimidine tract-binding protein 1 (PTBP1) is essential for B cell development at the pro-B cell stage where it suppresses S-phase entry and promotes progression through mitosis.
9. 1. Chromosomes and Gene Expression

   Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta

   Eric Engelbrecht et al.

   The sphingosine 1-phosphate receptor-1 (S1PR1) signals in heterogenous populations of mouse adventitial lymphatic (LEC) and arterial endothelial cells (aEC1, aEC2) to regulate chromatin and the transcriptome, thus affecting their phenotypes.
10. 1. Cell Biology
    2. Chromosomes and Gene Expression

    ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesin^STAG1 from WAPL

    Gordana Wutz et al.

    CTCF protects cohesin^STAG1 from WAPL.