Chromosomes and Gene Expression

Latest articles

1. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Dissociation of the nuclear basket triggers chromosome loss in aging yeast

   Mihailo Mirkovic, Jordan McCarthy ... Yves Barral
2. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Modeling metabolic disease susceptibility and resilience in genetically diverse mice

   Candice N Baker, Jeffrey M Harder ... Gary A Churchill
3. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Genome reorganization and its functional impact during breast cancer progression

   Kathleen S Metz Reed, Andrew Fritz ... Tom Misteli
4. 1. Chromosomes and Gene Expression
   2. Microbiology and Infectious Disease

   Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity

   Khund Sayeed, Sreeja Parameswaran ... Matthew T Weirauch

   Infection of human cells by human cytomegalovirus induces massive changes to human chromatin and reduction of TEAD1 activity.
5. 1. Chromosomes and Gene Expression
   2. Physics of Living Systems

   Criticality-driven enhancer-promoter dynamics in Drosophila chromosomes

   Gautham Ganesh, Jean-Bernard Fiche ... Julien Mozziconacci
6. 1. Chromosomes and Gene Expression
   2. Plant Biology

   Short heat shock factor A2 confers heat sensitivity in Arabidopsis: Insights into heat resistance and growth balance

   Wanxia Chen, Jiaqi Zhao ... Xiaoting Qi
7. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   DNA methylation insulates genic regions from CTCF loops near nuclear speckles

   Shelby A Roseman, Allison P Siegenfeld ... Brian B Liau

   CTCF binding promotes chromatin-nuclear speckle interactions and gene activation after DNA demethylation, yet its binding and looping patterns are unaffected by speckle depletion.
8. 1. Chromosomes and Gene Expression

   Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

   Carmen Ruger-Herreros, Lucia Svoboda ... Bernd Bukau
9. 1. Chromosomes and Gene Expression
   2. Immunology and Inflammation

   Cap-independent co-expression of dsRNA-sensing and NF-κB pathway inhibitors enables controllable self-amplifying RNA expression with reduced immunotoxicity

   Tony KY Lim, Anne Ritoux ... Ewan St John Smith

   Engineering self-amplifying RNA to intrinsically disarm the innate immune pathways it triggers enables durable, externally controlled gene expression with reduced cytotoxicity and cytokine release, eliminating the need for exogenous immunosuppressants.
10. 1. Cell Biology
    2. Chromosomes and Gene Expression

    Enalapril mitigates senescence and aging-related phenotypes in human cells and mice via pSmad1/5/9-driven antioxidative genes

    Wencong Lyu, Haochen Wang ... Wei Tao

    Enalapril combats the effects of senescence by activating the pSmad1/5/9–antioxidative gene axis, enhancing antioxidative defenses and promoting cell proliferation, thereby supporting healthy aging.