Chromosomes and Gene Expression

Latest articles

1. 1. Chromosomes and Gene Expression

   Cdc7 activates replication checkpoint by phosphorylating the Chk1-binding domain of Claspin in human cells

   Chi-Chun Yang et al.

   Cdc7 and CK1g1 independently and additively phosphorylate the Chk1-binding domain of claspin to activate replication checkpoint with differential contribution of each kinase in different cell types.
2. 1. Cell Biology
   2. Chromosomes and Gene Expression

   TRF1 averts chromatin remodelling, recombination and replication dependent-break induced replication at mouse telomeres

   Rosa Maria Porreca et al.

   TRF1 suppresses replication fork stalling, which triggers break induced replication at telomeres associated with DNA damage response, alteration in the telomere chromatin environment, and re-localisation of telomeres to PML bodies.
3. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukaemia stem-like cells

   Ana Filipa Domingues et al.
4. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in C. elegans

   Teresa Wei-sy Lee et al.

   The transgenerational inheritance of lifespan is facilitated by the accumulation of repressive chromatin across generations.
5. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Epigenetics: A memory of longevity

   Felicity Emerson et al.

   Worms with increased levels of the epigenetic mark H3K9me2 have a longer lifespan that can be passed down to future generations.
6. 1. Chromosomes and Gene Expression

   Two roles for the yeast transcription coactivator SAGA and a set of genes redundantly regulated by TFIID and SAGA

   Rafal Donczew et al.

   The transcription coactivators SAGA and TFIID have redundant function at a subset of yeast genes while SAGA also contributes to transcription of all genes through regulation of chromatin modifications.
7. 1. Chromosomes and Gene Expression

   Stop codon context influences genome-wide stimulation of termination codon readthrough by aminoglycosides

   Jamie R Wangen, Rachel Green
8. 1. Chromosomes and Gene Expression

   The genetic basis of aneuploidy tolerance in wild yeast

   James Hose et al.

   A single gene allele underlies differences in aneuploidy tolerance in yeast.
9. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Transcriptional adaptation in Caenorhabditis elegans

   Vahan Serobyan et al.

   Genes implicated in mutant mRNA decay and small RNA maturation and transport into the nucleus are required for transcriptional adaptation in C. elegans.
10. 1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Perturbation of base excision repair sensitizes breast cancer cells to APOBEC3 deaminase-mediated mutations

    Birong Shen et al.

    Accumulation of mutations in some cancers is correlated with an aberration of DNA repair and access of a DNA deaminase to normal genomic DNA.