Chromosomes and Gene Expression

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Chromosomes and Gene Expression

   A conserved Mcm4 motif is required for Mcm2-7 double-hexamer formation and origin DNA unwinding

   Kanokwan Champasa et al.

   Analysis of an essential motif in Mcm4 provides insights into replicative helicase double-hexamer formation and the first step requiring this intermediate during replication initiation.
2. 1. Chromosomes and Gene Expression
   2. Stem Cells and Regenerative Medicine

   TERRA regulate the transcriptional landscape of pluripotent cells through TRF1-dependent recruitment of PRC2

   Rosa María Marión et al.

   Telomeric TRF1 controls the transcriptional programmes of pluripotent stem cells by recruiting PRC2 to pluripotency and differentiation genes by controlling the expression of those gene sites and the binding of TERRA RNAs to them.
3. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   A genetic selection reveals functional metastable structures embedded in a toxin-encoding mRNA

   Sara Masachis et al.
4. 1. Chromosomes and Gene Expression

   piRNA-guided co-transcriptional silencing coopts nuclear export factors

   Martin H Fabry et al.

   A member of the Drosophila Nuclear Export Factor (Nxf) family, Nxf2, forms part of the piRNA-dependent co-transcriptional silencing complex and is essential for transposon repression in fly ovaries.
5. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD

   Mahmoud M Elguindy et al.

   Interaction with PUMILIO is essential for maintenance of genomic stability by the cytoplasmic long noncoding RNA NORAD, whereas binding to RBMX is dispensable for this function.
6. 1. Chromosomes and Gene Expression
   2. Plant Biology

   Epimutations are associated with CHROMOMETHYLASE 3-induced de novo DNA methylation

   Jered M Wendte et al.

   Simultaneous targeting of loci by pathways that promote euchromatin and heterochromatin primes transcribed genes for epimutations in the form of CG DNA methylation.
7. 1. Chromosomes and Gene Expression
   2. Neuroscience

   Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters

   Nikolai Petkau et al.

   Acetylation of the circadian transcription factor BMAL1 by the acetyltransferase TIP60 is crucial for recruitment of the pause release factors to clock gene promoters and productive elongation of these genes.
8. 1. Chromosomes and Gene Expression
   2. Developmental Biology

   Multi-enhancer transcriptional hubs confer phenotypic robustness

   Albert Tsai et al.

   Multiple enhancers in physical proximity can reinforce shared transcriptional 'hubs' to preserve their transcriptional output, providing a buffer during environmental stresses and genetic perturbations to preserve phenotypic robustness.
9. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Translational regulation of protrusion-localized RNAs involves silencing and clustering after transport

   Konstadinos Moissoglu et al.

   RNAs enriched at cell protrusions are translated regardless of their location in the cytoplasm but are dynamically repressed in retracting protrusions and incorporated into heterogeneous RNA clusters.
10. 1. Cell Biology
    2. Chromosomes and Gene Expression

    Contractile acto-myosin network on nuclear envelope remnants positions human chromosomes for mitosis

    Alexander JR Booth et al.

    Live-cell imaging shows that the contractile acto-myosin network on the nuclear envelope remnant positions chromosomes in early mitosis to ensure efficient and correct interactions between chromosomes and the mitotic spindle.