Chromosomes and Gene Expression

Chromosomes and Gene Expression

eLife reviews research ranging from transcription and RNA processing to epigenetics and chromatin biology. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Transcription: The plusses and minuses of DNA torsion

    Steven Henikoff, David L Levens
    A new method for mapping torsion provides insights into the ways that the genome responds to the torsion generated by RNA polymerase II.
    Version of Record
    Insight
    1. Chromosomes and Gene Expression

    Nuclear Argonaute protein NRDE-3 switches small RNA partners during embryogenesis to mediate temporal-specific gene regulatory activity

    Shihui Chen, Carolyn M Phillips
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Interplay of YEATS2 and GCDH mediates histone crotonylation and drives EMT in head and neck cancer

    Deepak Pant, Parik Kakani ... Sanjeev Shukla
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    PRDM16 functions as a co-repressor in the BMP pathway to suppress neural stem cell proliferation

    Li He, Jiayu Wen, Qi Dai
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    High-Resolution Genome-Wide Maps Reveal Widespread Presence of Torsional Insulation

    Porter M Hall, Lauren A Mayse ... Michelle D Wang
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The conserved ATPase PCH-2 controls the number and distribution of crossovers by antagonizing their formation in Caenorhabditis elegans

    Bhumil Patel, Maryke Grobler ... Needhi Bhalla
    By regulating the chromosome axis component and meiotic HORMAD, HIM-3, the conserved AAA-ATPase PCH-2 controls the number and distribution of meiotic recombination events.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition

    Gülnihal Kavaklıoğlu, Alexandra Podhornik ... Christian Seiser
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape

    Ashley L Cook, Surojit Sur ... Nicolas Wyhs
    Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Genome Restructuring around Innate Immune Genes in Monocytes in Alcohol-associated Hepatitis

    Adam Kim, Megan R McMullen ... Srinivasan Dasarathy
    Not revised
    Reviewed Preprint v1
    • Incomplete
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Enalapril mitigates aging by targeting antioxidative genes via phosphorylated Smad1/5/9

    Wencong Lyu, Haochen Wang ... Wei Tao
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
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Highlights

    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Torsional insulation in the genome

    Steven Henikoff, David L Levens
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Navigating the secrets of COMPASS

    Karolin Luger, Jonathan W Markert
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Reality check for transposons

    Julie Brind'Amour, Dixie L Mager

Senior editors

  1. Yamini Dalal
    National Cancer Institute, United States
  2. Silke Hauf
    Virginia Tech, United States
  3. Adèle L Marston
    University of Edinburgh, United Kingdom
  4. See more editors