Chromosomes and Gene Expression

Latest articles

1. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones

   Jay F Sarthy et al.

   Deposition of mutant oncohistones by alternative nucleosome assembly pathways results in dramatic local differences in histone methylation in pediatric diffuse midline gliomas.
2. 1. Chromosomes and Gene Expression
   2. Plant Biology

   Natural variation in autumn expression is the major adaptive determinant distinguishing Arabidopsis FLC haplotypes

   Jo Hepworth et al.

   Variation in autumnal expression from starting expression levels and initial cold-down-regulation, rather than epigenetic silencing, is the major field variable conferred by worldwide haplotypes of the floral repressor gene, FLC.
3. 1. Chromosomes and Gene Expression

   Identification of protein-protected mRNA fragments and structured excised intron RNAs in human plasma by TGIRT-seq peak calling

   Jun Yao et al.

   Human plasma contains protein-protected mRNA fragments, myriad repeat RNAs, and novel intron RNAs, including a family of structured full-length excised introns, some corresponding to mirtron pre-miRNAs and agotrons.
4. 1. Cell Biology
   2. Chromosomes and Gene Expression

   Large domains of heterochromatin direct the formation of short mitotic chromosome loops

   Maximilian H Fitz-James et al.

   Large regions of foreign DNA inserted into mammalian chromosomes assemble into H3K9me3-heterochromatin and result in increased condensin loading with organisation into shorter mitotic chromosome loops than endogenous DNA.
5. 1. Chromosomes and Gene Expression

   Ribosome recycling is not critical for translational coupling in E. coli

   Kazuki Saito et al.
6. 1. Chromosomes and Gene Expression

   Genome-wide alterations of uracil distribution patterns in human DNA upon chemotherapeutic treatments

   Hajnalka L Pálinkás et al.

   Human genomic DNA contains uracil in the late replicating, constitutive heterochromatic regions, while treatment with drugs perturbing thymidylate biosynthesis shifts the uracil distribution pattern towards the euchromatin in UNG-inhibited cells.
7. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   Coverage-dependent bias creates the appearance of binary splicing in single cells

   Carlos F Buen Abad Najar et al.

   Sequencing and counting RNAs from single cells can create a misleading picture of alternative splicing if too many mRNAs are lost in the process.
8. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   Shadow enhancers can suppress input transcription factor noise through distinct regulatory logic

   Rachel Waymack et al.

   Proper development depends on establishing precise gene expression patterns in spite of the inherent noise in transcription, shadow enhancers buffer this noise by binding distinct input transcription factors.
9. 1. Chromosomes and Gene Expression
   2. Evolutionary Biology

   Genomic architecture and evolutionary antagonism drive allelic expression bias in the social supergene of red fire ants

   Carlos Martinez-Ruiz et al.

   Analyses of allelic- and socially-biased gene expression reveal that suppressed recombination causes most of the expression differences in the social supergene, with only few differences due to socially antagonistic selection.
10. 1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Co-expression analysis reveals interpretable gene modules controlled by trans-acting genetic variants

    Liis Kolberg et al.

    Co-expression analysis combined with functional enrichment improves the detection and prioritisation of trans-eQTLs when applied to emerging cell-type-specific datasets.