About
Editors and people

Editors for Computational and Systems Biology

We aim to review studies that use computational methods, models and software to provide important biological insights in all areas of the life sciences. Read the latest research in this subject area.

Type

Senior editors

Christian R Landry

Université Laval, Canada

Christian Landry received a BSc and a MSc in Biology from Université Laval and a PhD from Harvard University. His postdoc was in Biochemistry at Université de Montréal. He was then recruited as a New Investigator of the Canadian Institute of Health Research at Université Laval. He now holds the Canada Research Chair in Cellular Systems and Synthetic Biology. His research interests are in understanding how genetic variation and the organization of cellular systems interact to shape the ways evolution proceeds.

Expertise
Evolutionary Biology
Genetics and Genomics
Computational and Systems Biology

Research focus
evolutionary genomics
experimental evolution
gene duplication
evolution of proteins
genome engineering
cellular networks

Experimental organism
S. cerevisiae
E. coli
Fungal pathogens

Competing interests statement
Christian Landry’s research is funded by the Natural Sciences and Engineering Research Council of Canada, the Canadian Institute of Health Research, Genome Canada, Genome Québec, Fonds de recherche du Québec - Nature and Technologies and the Human Frontiers Science Program. He is a member of the editorial board of Review Commons, Molecular Systems Biology, Yeast and Genetics.
Aleksandra Walczak

Ecole Normale Superieure, France

Aleksandra Walczak received her PhD in physics at UCSD working on models of stochastic gene expression. After a graduate fellowship at KITP, she was a Princeton Center for Theoretical Science Fellow, focusing on applying information theory to signal processing in small gene regulatory networks. Currently she is a CNRS researcher at the Ecole Normale Superieure in Paris, interested in a variety of problems in the physics of living systems.

She actively works on development, collective behavior of bird flocks and statistical descriptions of the immune system.

Expertise
Computational and Systems Biology
Immunology and Inflammation
Physics of Living Systems

Research focus
biophysics
quantitative immunology
probabilistic data analysis
theoretical models
development
collective behaviour

Competing interests statement
Aleksandra Walczak is the recipient of a CNRS-Chicago Cooperation Grant, a FACCTS CNRS-Chicago Cooperation Grant, an IRN CNRS Predictability, Adaptability Evolution network collaboration grant, a CNRS-MIT Cooperation Grant, a q-Life Grant "The physics of repair and silencing foci?, an ERC Proof of Concept Grant "Automated evaluation and correction of generation bias in immune receptor repertoires", a DFG CRC "Predictability in evolution", an ERC International Training Network QuanTII grant, and an ERC Consolidator Grant "Statistical physics of immune-viral co-evolution”.

Reviewing editors

Fernán Agüero

Universidad Nacional de San Martín, Argentina

Expertise
Biochemistry and Chemical Biology
Chromosomes and Gene Expression
Computational and Systems Biology
Evolutionary Biology
Genetics and Genomics
Immunology and Inflammation
Microbiology and Infectious Disease

Research focus
genomics
drug discovery
diagnostics
infectious diseases
microbial eukaryotes
bioinformatics
David B Allison

Indiana University, United States

Expertise
Medicine
Genetics and Genomics
Epidemiology and Global Health
Computational and Systems Biology
Evolutionary Biology

Research focus
experimental design
statistics
longevity
biostatistics
obesity
nutrition
senescence
research rigour
science integrity
Joon-Yong An

Korea University, South Korea

Expertise
Medicine
Computational and Systems Biology
Genetics and Genomics
Neuroscience

Research focus
whole genome sequencing
noncoding mutation
neurodevelopment
autism spectrum disorders
multi-omics
Carl T Bergstrom

University of Washington, United States

Expertise
Computational and Systems Biology

Research focus
metaresearch
science of science
science studies
metaknowledge
philosophy of science
bibliometrics
Gordon Berman

Emory University, United States

Expertise
Computational and Systems Biology
Neuroscience
Physics of Living Systems

Research focus
animal behavior
theoretical biophysics
computational neuroscience
computational ethology

Experimental organism
D. melanogaster
mouse
rat
Anne-Florence Bitbol

Ecole Polytechnique Federale de Lausanne , Switzerland

Expertise
Physics of Living Systems
Computational and Systems Biology

Research focus
biophysics
theory and modeling
protein sequence data
models of evolution
Nyasha Chambwe

St Jude Children's Research Hospital, United States

Expertise
Cancer Biology
Computational and Systems Biology
Genetics and Genomics

Research focus
bioinformatics
computational biology
cancer genomics
population genomics
data analysis

Experimental organism
human
Jungmin Choi

Korea University College of Medicine, South Korea

Expertise
Cancer Biology
Computational and Systems Biology
Genetics and Genomics
Medicine

Research focus
rare disorders
single cell genomics
computational biology
human genomics
Ben Cooper

Mahidol Oxford Tropical Medicine Research Unit, Thailand

Expertise
Computational and Systems Biology
Epidemiology and Global Health

Research focus
population biology of communicable diseases
antimicrobial resistance
epidemiological methods
Leslie D Cope

Johns Hopkins University, United States

Expertise
Cancer Biology
Computational and Systems Biology
Genetics and Genomics

Research focus
bioinformatics
biostatistics
high-throughput genomic data
methods for identifying and validating biomarkers
Noah J Cowan

The Johns Hopkins University, United States

Expertise
Neuroscience
Evolutionary Biology
Computational and Systems Biology

Research focus
sensorimotor control
active sensing
navigation
biomechanics
robotics
control theory
motor learning
Job Dekker

University of Massachusetts Medical School, United States

Expertise
Chromosomes and Gene Expression
Computational and Systems Biology
Genetics and Genomics

Research focus
chromosome folding
mitosis
chromatin
gene regulation

Experimental organism
human
mouse
yeast
dinoflagellates
Emek Demir

Oregon Health and Science University, United States

Expertise
Cancer Biology
Computational and Systems Biology
Genetics and Genomics
Medicine

Research focus
proteomics
Leonardo A Elias

University of Campinas, Brazil

Expertise
Computational and Systems Biology
Neuroscience

Research focus
computational neuroscience
sensorimotor systems
proprioception
motor unit physiology
motor neurons
electromyography
neurodegenerative diseases
Eduardo Eyras

Australian National University, Australia

Expertise
Genetics and Genomics
Cancer Biology
Chromosomes and Gene Expression
Computational and Systems Biology

Research focus
bioinformatics
transcriptomics
long-read sequencing technologies
RNA splicing
alternative splicing
nanopore
Jennifer Flegg

University of Melbourne, Australia

Expertise
Computational and Systems Biology
Epidemiology and Global Health

Research focus
mathematical modelling
mathematical biology
computational biology
infectious disease dynamics
Thomas Gingeras

Cold Spring Harbor Laboratory, United States

Expertise
Chromosomes and Gene Expression
Computational and Systems Biology
Genetics and Genomics
Microbiology and Infectious Disease

Research focus
genomics
gene expression
regulatory networks
chromosomal modification

Experimental organism
D. melanogaster
human
mouse
Julijana Gjorgjieva

Technical University of Munich, Germany

Expertise
Computational and Systems Biology
Neuroscience

Research focus
computational neuroscience
systems modeling
synaptic plasticity
cortical development
Mariana Gómez-Schiavon

Universidad Nacional Autónoma de México, Mexico

Expertise
Computational and Systems Biology
Evolutionary Biology

Research focus
systems biology
evolution dynamics
gene regulatory circuits
mathematical modeling
nonlinear dynamics
epigenetics
bistability
circadian rhythms
oscillations
homeostasis
feedback control
Martin Graña

Institut Pasteur de Montevideo, Uruguay

Expertise
Biochemistry and Chemical Biology
Computational and Systems Biology
Evolutionary Biology
Physics of Living Systems
Structural Biology and Molecular Biophysics

Research focus
protein 3D structure
structural bioinformatics
structure/function relationships
evolution
Frederik Graw

Heidelberg University, Germany

Expertise
Immunology and Inflammation
Computational and Systems Biology
Microbiology and Infectious Disease

Research focus
mathematical modelling
theoretical immunology
host-pathogen interactions
viral spread
infection dynamics

Experimental organism
mouse
viruses
Rebekah L. Gundry

University of Nebraska Medical Center, United States

Expertise
Biochemistry and Chemical Biology
Computational and Systems Biology
Stem Cells and Regenerative Medicine

Research focus
mass spectrometry
cell surface glycoproteins
proteomics
glycomics
heart failure
stem cell derived cardiomyocytes
biomarkers
Adam Haber

Harvard TH Chan School of Public Health, United States

Expertise
Computational and Systems Biology
Genetics and Genomics
Medicine

Research focus
asthma
machine learning
Shozeb Haider

University College London, United Kingdom

Expertise
Medicine
Structural Biology and Molecular Biophysics
Computational and Systems Biology
Microbiology and Infectious Disease

Research focus
X-ray crystallography
molecular dynamics simulations
allostery
structure-based drug design
structural bioinformatics
computational chemistry
nucleic acids
rare diseases
P Robin Hiesinger

Institute for Biology Free University Berlin, Germany

Expertise
Cell Biology
Computational and Systems Biology
Developmental Biology
Genetics and Genomics
Neuroscience

Research focus
brain development
synapse
neurogenetics
membrane trafficking
Drosophila
neurodegeneration
computational modelling
live-cell imaging

Experimental organism
D. melanogaster
organoids
Yaroslav Ispolatov

Universidad de Santiago de Chile, Chile

Expertise
Computational and Systems Biology
Ecology
Evolutionary Biology
Physics of Living Systems

Research focus
evolution
diversification
adaptive dynamics
ecology
systems biology
CRISPR
Mohammad M Karimi

Kings College London, United Kingdom

Expertise
Medicine
Computational and Systems Biology

Research focus
bioinformatics
genomics
epigenomics
transposable elements
single-cell sequencing
visual analytics
epigenetic therapy
Caleb Kemere

Rice University, United States

Expertise
Neuroscience
Computational and Systems Biology

Research focus
computational tools for hippocampal electrophysiological signals
place cells
replay
hippocampal rhythms
Mary B Kennedy

California Institute of Technology, United States

Expertise
Biochemistry and Chemical Biology
Computational and Systems Biology
Neuroscience

Research focus
synaptic plasticity
synaptic regulation
biochemical signal transduction networks
systems biology

Experimental organism
mouse
rat
Ahmad S Khalil

Boston University, United States

Expertise
Chromosomes and Gene Expression
Computational and Systems Biology

Research focus
synthetic biology
systems biology
gene regulation
epigenetics
molecular evolution
technology development
Daniel J Kliebenstein

University of California, Davis, United States

Expertise
Biochemistry and Chemical Biology
Computational and Systems Biology
Ecology
Genetics and Genomics
Plant Biology

Research focus
genetics
genomics
transcriptomics
metabolomics
pathogen
plant metabolism
fitness

Experimental organism
A. thaliana
B. cinerea
eudicots
David M Kramer

Michigan State University, United States

Expertise
Biochemistry and Chemical Biology
Plant Biology
Physics of Living Systems
Computational and Systems Biology

Research focus
photosynthesis
bioenergetics
electron and proton transfer
computation
phenotyping
phenomics
Sandeep Krishna

National Centre for Biological Sciences ‐ Tata Institute of Fundamental Research, India

Expertise
Physics of Living Systems
Computational and Systems Biology

Research focus
gene regulatory networks
phage-bacteria interactions
microbial communities
multistability
oscillations and synchronization
Emilio Kropff

Leloir Institute - IIBBA/CONICET, Argentina

Expertise
Computational and Systems Biology
Neuroscience

Research focus
hippocampus
memory
navigation
computational models
entorhinal cortex
attractors
Peter Latham

University College London, United Kingdom

Expertise
Computational and Systems Biology
Neuroscience

Research focus
computational neuroscience
bayesian inference
network dynamics
neural coding
synaptic plasticity
Hongliang Li

Wuhan University School of Medicine, China

Expertise
Biochemistry and Chemical Biology
Computational and Systems Biology
Epidemiology and Global Health
Immunology and Inflammation
Medicine

Research focus
cardiometabolic disease
metabolic disease
vascular injury
animal models
liver
innate immunity
Andrea E Martin

Max Planck Institute for Psycholinguistics, Netherlands
Donders Centre for Cognitive Neuroimaging, Netherlands

Expertise
Neuroscience
Computational and Systems Biology

Research focus
language
speech
cognition
computational modeling
oscillations
structured representations in neural systems
magnetoencephalography (MEG)
electroencephalography (EEG)
neuroimaging

Experimental organism
human
Markus Meister

California Institute of Technology, United States

Expertise
Neuroscience
Computational and Systems Biology

Research focus
computational neuroscience
theoretical neuroscience
systems neuroscience
vision
retina
superior colliculus
electrophysiology
magnetoreception
Babak Momeni

Boston College, United States

Expertise
Computational and Systems Biology
Microbiology and Infectious Disease
Physics of Living Systems

Research focus
microbial communities
community ecology
mathematical modelling
computational biology
applied microbiology
bioremediation
mycotoxins
nasal microbiota
Alan Moses

University of Toronto, Canada

Expertise
Computational and Systems Biology
Evolutionary Biology
Genetics and Genomics

Research focus
data analysis
bioinformatics
molecular evolution
intrinsically disordered proteins
signaling pathways
regulatory networks

Experimental organism
S. cerevisiae
Marcos Nahmad

Centre for Research and Advanced Studies, Mexico

Expertise
Computational and Systems Biology
Developmental Biology
Genetics and Genomics
Physics of Living Systems

Research focus
growth control
drosophila genetics
developmental patterning
mathematical modelling
Richard A Neher

University of Basel, Switzerland

Expertise
Computational and Systems Biology
Physics of Living Systems
Evolutionary Biology

Research focus
population genetics
evolution of RNA viruses
bioinformatics
Marisa Nicolás

Laboratório Nacional de Computação Científica, Brazil

Expertise
Chromosomes and Gene Expression
Computational and Systems Biology
Genetics and Genomics
Microbiology and Infectious Disease

Research focus
molecular biology
bioinformatics
genomics
transcriptomics
multi-omics approaches
clinical pathogens
antimicrobial resistance
metabolic regulatory networks
transcriptional regulatory networks
Armita Nourmohammad

University of Washington, United States

Expertise
Computational and Systems Biology
Evolutionary Biology
Physics of Living Systems
Immunology and Inflammation

Research focus
population genetics
computational immunology
adaptive immunity
statistical physics
deep mutational scanning
information theory
statistical inference
gene expression evolution

Experimental organism
D. melanogaster
human
viruses
Timothy O'Leary

Cambridge University, United Kingdom

Expertise
Computational and Systems Biology
Neuroscience
Physics of Living Systems

Research focus
computational neuroscience
theoretical neuroscience
neurophysiology
systems neuroscience
homeostasis

Experimental organism
mouse
rat
D. melanogaster
cancer borealis
C. Brandon Ogbunugafor

Yale University, United States

Expertise
Computational and Systems Biology
Evolutionary Biology
Epidemiology and Global Health
Physics of Living Systems
Microbiology and Infectious Disease

Research focus
disease ecology
microbial evolution
population genetics
epidemiology
evolutionary medicine

Experimental organism
E. coli
human
P. falciparum
S. cerevisiae
viruses
Srdjan Ostojic

École Normale Supérieure, France

Expertise
Neuroscience
Computational and Systems Biology

Research focus
computational neuroscience
network dynamics
neural computations
population coding
neural circuits
plasticity
Akhilesh Pandey

Mayo Clinic, United States

Expertise
Biochemistry and Chemical Biology
Computational and Systems Biology

Research focus
proteomics
quantitative proteomics
Stephen Parker

University of Michigan, United States

Expertise
Genetics and Genomics
Chromosomes and Gene Expression
Computational and Systems Biology

Research focus
diabetes
disease susceptibility
functional genomics
comparative genomics
population genomics

Experimental organism
human
mouse
rat
David A Paz-Garcia

Centro de Investigaciones Biológicas del Noroeste (CIBNOR), Mexico

Expertise
Chromosomes and Gene Expression
Computational and Systems Biology
Ecology
Evolutionary Biology
Genetics and Genomics
Microbiology and Infectious Disease
Plant Biology

Research focus
marine life
coral reefs
phylogenomics
population genomics
morphometrics
gene expression
statistics
coding
Luca Pinello

Massachusetts General Hospital, United States

Expertise
Medicine
Computational and Systems Biology
Genetics and Genomics

Research focus
bioinformatics
computational biology
CRISPR genome editing
single-cell genomics
Nicolás Pírez

Universidad de Buenos Aires - CONICET, Argentina

Expertise
Computational and Systems Biology
Neuroscience

Research focus
sensory physiology
olfactory system
neural circuits
circadian rhythms
learning and memory
behavior and genetics
in vivo imaging

Experimental organism
Drosophila melanogaster
mouse
Ignacio E Sanchez

CONICET / Universidad de Buenos Aires, Argentina

Expertise
Computational and Systems Biology
Structural Biology and Molecular Biophysics

Research focus
molecular biophysics
bioinformatics
systems biology
synthetic biology
proteomics
genomics
metabolomics
Marcus M Seldin

University of California, Irvine, United States

Expertise
Biochemistry and Chemical Biology
Computational and Systems Biology
Genetics and Genomics

Research focus
systems genetics
endocrine physiology
metabolism
cell-cell communication
Agnese Seminara

Université Côte d'Azur, France

Expertise
Computational and Systems Biology
Physics of Living Systems

Research focus
biomechanics of bacterial biofilm growth
violent discharge
atmospheric dispersal of fungal spores
computational navigation

Experimental organism
B. subtilis
mouse
Thomas Serre

Brown University, United States

Expertise
Computational and Systems Biology
Neuroscience

Research focus
vision
computational neuroscience
deep learning

Experimental organism
monkey
Reut Shalgi

Technion - Israel Institute of Technology, Israel

Expertise
Cell Biology
Genetics and Genomics
Computational and Systems Biology
Chromosomes and Gene Expression

Research focus
stress response
ER stress
UPR
heat shock response
chaperones
protein aggregation
Wenying Shou

University College London, United Kingdom

Expertise
Computational and Systems Biology
Ecology
Evolutionary Biology
Genetics and Genomics

Research focus
quantitative biology
mathematical biology
evolutionary biology
synthetic biology
molecular genetics
evolution of cooperation
computer simulations

Experimental organism
S. cerevisiae
Alex Sigal

Africa Health Research Institute, University of KwaZulu-Natal, South Africa

Expertise
Computational and Systems Biology
Evolutionary Biology
Microbiology and Infectious Disease

Research focus
SARS-CoV-2
COVID-19
antibody neutralisation
viral evolution
experimental evolution
cell-to-cell viral spread
Ihor Smal

Erasmus University Medical Center, Netherlands

Expertise
Cell Biology
Computational and Systems Biology

Research focus
image analysis
machine learning
Mashaal Sohail

National Autonomous University of Mexico, Mexico

Expertise
Computational and Systems Biology
Evolutionary Biology
Genetics and Genomics
Epidemiology and Global Health

Research focus
population genetics
complex traits
natural selection
population structure
demographic history
genomics
equity
anthropological genetics
Cassidy Sugimoto

Georgia Institute of Technology, United States

Expertise
Computational and Systems Biology

Research focus
metaresearch
science of science
science policy
gender
scholarly communication
Daniel Y Takahashi

Universidade Federal do Rio Grande do Norte, Brazil

Expertise
Computational and Systems Biology
Ecology
Neuroscience
Physics of Living Systems

Research focus
social interaction
vocal learning
neurophysiology
computational modeling
ontogeny of behavior
Alan Talevi

National University of La Plata, Argentina

Expertise
Biochemistry and Chemical Biology
Computational and Systems Biology
Microbiology and Infectious Disease
Structural Biology and Molecular Biophysics

Research focus
bioinformatics
drug discovery
cheminformatics
pharmacy
David Van Valen

California Institute of Technology, United States

Expertise
Physics of Living Systems
Computational and Systems Biology

Research focus
encoding
viral decision making
living systems
image segmentation
Timothy Verstynen

Carnegie Mellon University, United States

Expertise
Computational and Systems Biology
Neuroscience

Research focus
neuroscience
white matter
brain sensorimotor pathways
plasticity
action planning
decision-making
complex skill learning
obesity
basal ganglia
striatum
drift diffusion models
attractor networks

Experimental organism
human
Martin Vinck

Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Germany

Expertise
Neuroscience
Computational and Systems Biology

Research focus
neural coding
vision
computation
behavioral State
functional connectivity
cell types
oscillations
predictive coding

Experimental organism
mouse
rat
human
R.macaque
Linghua Wang

The University of Texas MD Anderson Cancer Center, United States

Expertise
Cancer Biology
Computational and Systems Biology
Genetics and Genomics
Immunology and Inflammation
Medicine

Research focus
computational biology
cancer immunogenomics
cancer genomics
Yongliang Yang

Dalian University of Technology, China

Expertise
Medicine
Cancer Biology
Computational and Systems Biology

Research focus
bioinformatics
computational biology
drug discovery
artificial intelligence
Gene W Yeo

University of California, San Diego, United States

Expertise
Chromosomes and Gene Expression
Cell Biology
Computational and Systems Biology
Genetics and Genomics
Neuroscience
Stem Cells and Regenerative Medicine

Research focus
RNA biology
computational biology
CRISPR
neurodegeneration
single cell biology

Experimental organism
human
mouse
Assaf Zaritsky

Ben-Gurion University of the Negev, Israel

Expertise
Computational and Systems Biology
Cell Biology

Research focus
collective cell behavior
computational cell dynamics
data science in cell imaging
multicellular information processing
interpretable machine learning
high content image-based phenotyping
artificial intelligence in IVF
analysis of spatial multiplexed data
cell shape and intracellular organization
Hang Zhang

Peking University, China

Expertise
Neuroscience
Computational and Systems Biology

Research focus
computational modeling
decision making
cognition
learning
probabilistic structure
inductive bias
rational analysis
EEG/MEG

Experimental organism
human
Siming Zhao

Dartmouth College, United States

Expertise
Medicine
Computational and Systems Biology
Genetics and Genomics

Research focus
statistical genetics
genomics
human genetics
sequencing data