Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology

   Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism

   David Dierks, Ran Shachar ... Schraga Schwartz
2. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   Exploring the repository of de novo-designed bifunctional antimicrobial peptides through deep learning

   Ruihan Dong, Rongrong Liu ... Cheng Zhu

   Peptides designed by artificial intelligence restrict both drug-resistant bacteria and rapidly evolving viruses.
3. 1. Immunology and Inflammation
   2. Computational and Systems Biology

   Tissue resident memory CD4⁺ T cells are sustained by site-specific levels of self-renewal and replacement from precursors

   Jodie Chandler, M Elise Bullock ... Andrew J Yates
4. 1. Computational and Systems Biology
   2. Neuroscience

   A statistical framework for analysis of trial-level temporal dynamics in fiber photometry experiments

   Gabriel Loewinger, Erjia Cui ... Francisco Pereira

   A fiber photometry analysis framework based on functional mixed models enhances the detection of effects by testing signal-variable associations at each trial timepoint and accounting for between-animal heterogeneity.
5. 1. Immunology and Inflammation
   2. Computational and Systems Biology

   Celldetective: an AI-enhanced image analysis tool for unraveling dynamic cell interactions

   Rémy Torro, Beatriz Díaz-Bello ... Laurent Limozin
6. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike

   A Sofia F Oliveira, Fiona L Kearns ... Adrian J Mulholland
7. 1. Computational and Systems Biology

   Efficient coding in biophysically realistic excitatory-inhibitory spiking networks

   Veronika Koren, Simone Blanco Malerba ... Stefano Panzeri

   Recurrent spiking networks that process input stimuli with optimal efficiency have key emerging properties that are similar to those of biological neural networks.
8. 1. Computational and Systems Biology

   Raw signal segmentation for estimating RNA modification from Nanopore direct RNA sequencing data

   Guangzhao Cheng, Aki Vehtari, Lu Cheng
9. 1. Computational and Systems Biology

   Evaluation of information flows in the RAS-MAPK system using transfer entropy measurements

   Nobuhisa Umeki, Yoshiyuki Kabashima, Yasushi Sako

   Assessment of transfer entropy is useful for network analysis of cell signaling network providing information on the network topology and action points of genetic mutations and drug effect, thus will be applicable to molecular pharmacology and pathology.
10. 1. Computational and Systems Biology
    2. Genetics and Genomics

    Discovering root causal genes with high-throughput perturbations

    Eric V Strobl, Eric Gamazon

    Root causal genes correspond to the initial changes to gene expression that induce a diagnosis and can be reliably detected from bulk RNA-seq after determining a causal ordering from Perturb-seq.