Computational and Systems Biology

Latest articles

1. 1. Cancer Biology
   2. Computational and Systems Biology

   Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions

   Christopher J Lord et al.
2. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Identifying the immune interactions underlying HLA class I disease associations

   Bisrat J Debebe et al.

   HLA class I-disease associations have been studied for decades; a new approach for investigating the underlying mechanism can overcome past problems with interpretation and help to understand the etiology of human diseases.
3. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Nuclei determine the spatial origin of mitotic waves

   Felix Eduard Nolet et al.
4. 1. Computational and Systems Biology
   2. Human Biology and Medicine

   SARS-CoV-2 strategically mimics proteolytic activation of human ENaC

   Praveen Anand et al.
5. 1. Computational and Systems Biology
   2. Neuroscience

   The natverse, a versatile toolbox for combining and analysing neuroanatomical data

   Alexander Shakeel Bates et al.

   Open source software enables neuroscientists to integrate single neuron or synaptic-resolution datasets from different imaging modalities to analyse morphology and connectivity at the scale of whole brains and connectomes.
6. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Slightly beneficial genes are retained by bacteria evolving DNA uptake despite selfish elements

   Bram van Dijk et al.
7. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Predictable properties of fitness landscapes induced by adaptational tradeoffs

   Suman G Das et al.
8. 1. Computational and Systems Biology
   2. Neuroscience

   Meta-Research: Dataset decay and the problem of sequential analyses on open datasets

   William Hedley Thompson et al.

   Open data provides an opportunity to perform new analyses on preexisting data, but trade-offs are required to limit an increase in false positives.
9. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Stimulation strength controls the rate of initiation but not the molecular organization of TCR-induced signalling

   Claire Y Ma et al.
10. 1. Computational and Systems Biology
    2. Immunology and Inflammation

    Immunogenetics: Untangling the immune basis of disease susceptibility

    Ruy M Ribeiro, Luis Graca

    Interactions between immune cell receptors and proteins that determine disease susceptibility shed light on how different arms of the immune system are involved in three viral infections and Crohn's disease.