Computational and Systems Biology

Latest articles

1. 1. Cell Biology
   2. Computational and Systems Biology

   Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells

   Peter Jan Hooikaas et al.

   Kinesin-4 KIF21B promotes rapid reorientation of the microtubule network during formation of immunological synapse in T cells by acting as a pausing and catastrophe-inducing factor that keeps microtubules short.
2. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   Molecular basis for the adaptive evolution of environment-sensing by H-NS proteins

   Xiaochuan Zhao et al.

   Combining in silico and experimental approaches to identify and understand the residue changes in the H-NS protein that allowed bacteria to adapt environment-sensing to different habitats.
3. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Biological constraints on GWAS SNPs at suggestive significance thresholds reveal additional BMI loci

   Reza K Hammond et al.

   By integrating GWAS data sets with ATAC-seq and promoter-focused Capture C data, one can uncover further loci beyond those that reach genome-wide significance (p<5x10^-8).
4. 1. Computational and Systems Biology
   2. Neuroscience

   Bi-channel Image Registration and Deep-learning Segmentation (BIRDS) for efficient, versatile 3D mapping of mouse brain

   Xuechun Wang et al.
5. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Repeated outbreaks drive the evolution of bacteriophage communication

   Hilje M Doekes et al.
6. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   Modeling transfer of vaginal microbiota from mother to infant in early life

   Martin Steen Mortensen et al.

   Modeling weighted transfer ratios enable statistical analysis of maternal–infant transfer at a more general level and can indicate whether any transfer is persistent, transient, or originates from alternate sources.
7. 1. Computational and Systems Biology
   2. Medicine

   Reproducible analysis of disease space via principal components using the novel R package syndRomics

   Abel Torres Espín et al.
8. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection

   Anastasia A Minervina et al.

   Longitudinal tracking of individual T-cell clones reveals the expansion of pre-existing T-cell memory in response to SARS-CoV-2 infection.
9. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   Thresholds for post-rebound SHIV control after CCR5 gene-edited autologous hematopoietic cell transplantation

   E Fabian Cardozo-Ojeda et al.

   Mathematical models reveal the conditions required for long-term HIV remission using autologous transplantation of hematopoietic stem cells.
10. 1. Computational and Systems Biology
    2. Physics of Living Systems

    Spatial correlations constrain cellular lifespan and pattern formation in corneal epithelium homeostasis

    Lior Strinkovsky et al.

    Rejuvenation of corneal epithelium in homeostasis is determined by the interplay between corneal cells replicative lifespan and the spatial correlation between cell replication and cell removal.