Computational and Systems Biology

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   TASEP modelling provides a parsimonious explanation for the ability of a single uORF to derepress translation during the Integrated Stress Response

   Dmitry E Andreev et al.
2. 1. Computational and Systems Biology
   2. Structural Biology and Molecular Biophysics

   Computational design of thermostabilizing point mutations for G protein-coupled receptors

   Petr Popov et al.

   A comprehensive approach to prediction of stabilizing mutations in G-protein coupled receptors yields high hit rate and crystal structures of 5HT2C in both active and inactive states.
3. 1. Cell Biology
   2. Computational and Systems Biology

   Transcriptional profiling reveals extraordinary diversity among skeletal muscle tissues

   Erin E Terry et al.

   There is no such thing as a representative skeletal muscle tissue, as each member of this family of tissues expresses a specialized mRNA program.
4. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Shearing in flow environment promotes evolution of social behavior in microbial populations

   Gurdip Uppal, Dervis Can Vural

   Shearing in fluid flow induces or enhances budding dispersal in microbial populations, resulting in stronger cooperative behavior.
5. 1. Cell Biology
   2. Computational and Systems Biology

   Cell size sensing in animal cells coordinates anabolic growth rates and cell cycle progression to maintain cell size uniformity

   Miriam Bracha Ginzberg et al.
6. 1. Computational and Systems Biology
   2. Plant Biology

   Coordination of robust single cell rhythms in the Arabidopsis circadian clock via spatial waves of gene expression

   Peter D Gould et al.

   Single cell analysis reveals how period differences between cells and cell-to-cell coupling generates the spatial structure of the plant circadian clock.
7. 1. Computational and Systems Biology
   2. Epidemiology and Global Health

   The intractable challenge of evaluating cattle vaccination as a control for bovine Tuberculosis

   Andrew James Kerr Conlan et al.

   Natural transmission experiments should be prioritised over risky and expensive field trials, in order to establish the impact of cattle vaccination on the transmission of bovine Tuberculosis.
8. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   Computational prediction of CTCF/cohesin-based intra-TAD loops that insulate chromatin contacts and gene expression in mouse liver

   Bryan J Matthews, David J Waxman

   Certain types of 3D chromatin loops are easy to predict from existing or easily obtainable 2D information, which benefits gene expression studies in tissues/cells/organisms without extensive pre-existing 3D information.
9. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   The eukaryotic bell-shaped temporal rate of DNA replication origin firing emanates from a balance between origin activation and passivation

   Jean-Michel Arbona et al.
10. 1. Computational and Systems Biology
    2. Human Biology and Medicine

    The MR-Base platform supports systematic causal inference across the human phenome

    Gibran Hemani et al.

    Compiling public datasets into a single, centralised repository and linking directly to analytical software completely transforms the scale and scope of causal inference across the phenome.