Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Identifying the immune interactions underlying HLA class I disease associations

   Bisrat J Debebe et al.
2. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Deep evolutionary analysis reveals the design principles of fold A glycosyltransferases

   Rahil Taujale et al.
3. 1. Computational and Systems Biology
   2. Structural Biology and Molecular Biophysics

   Approaching boiling point stability of an alcohol dehydrogenase through computationally-guided enzyme engineering

   Friso S Aalbers et al.
4. 1. Computational and Systems Biology
   2. Neuroscience

   Theoretical relation between axon initial segment geometry and excitability

   Sarah Goethals, Romain Brette
5. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios

   Marc J Williams et al.

   Measurement of the distribution of fitness effects of new mutations arising in human oesophagus and skin, via new mathematical theory linking dn/ds values and fitness coefficients.
6. 1. Computational and Systems Biology
   2. Epidemiology and Global Health

   Reducing RSV hospitalisation in a lower-income country by vaccinating mothers-to-be and their households

   Samuel PC Brand et al.
7. 1. Cell Biology
   2. Computational and Systems Biology

   Deciphering anomalous heterogeneous intracellular transport with neural networks

   Daniel Han et al.
8. 1. Computational and Systems Biology
   2. Neuroscience

   A model for focal seizure onset, propagation, evolution, and progression

   Jyun-you Liou et al.

   Usage-dependent inhibition breakdown and neural adaptation underpins the key spatiotemporal dynamics of human focal seizures.
9. 1. Computational and Systems Biology
   2. Neuroscience

   Selectivity to approaching motion in retinal inputs to the dorsal visual pathway

   Todd R Appleby, Michael B Manookin

   Cells in the primate retina show unexpected sensitivity to approaching motion and optical flow.
10. 1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Structure-based discovery of potent and selective melatonin receptor agonists

    Nilkanth Patel et al.

    Large scale virtual screening using recently solved structures of Melatonin receptors yield discovery of 10 new high-affinity selective agonists, also revealing novel functional features, including biased signaling at Melatonin receptors.