Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Receptor-based mechanism of relative sensing and cell memory in mammalian signaling networks

   Eugenia Lyashenko et al.

   Preferential endocytosis of activated receptors allows cells to memorize their past and perform relative sensing.
2. 1. Computational and Systems Biology
   2. Neuroscience

   Sodium channels implement a molecular leaky integrator that detects action potentials and regulates neuronal firing

   Marco A Navarro et al.

   Kinetic interactions between sodium channels and auxiliary factors create a molecular computational engine that can sense and regulate cellular excitability.
3. 1. Computational and Systems Biology
   2. Developmental Biology

   Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human KRT8/18

   Huan Liu et al.

   Analysis of zebrafish periderm enhancers illuminates the conserved DNA of epithelial enhancers across species and prioritizes orofacial-cleft-associated regulatory variants near KRT18/KRT8.
4. 1. Computational and Systems Biology
   2. Neuroscience

   Selectivity to approaching motion in retinal inputs to the dorsal visual pathway

   Todd R Appleby, Michael B Manookin
5. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Primary and secondary anti-viral response captured by the dynamics and phenotype of individual T cell clones

   Anastasia A Minervina et al.
6. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Genetic Novelty: How new genes are born

   Urminder Singh, Eve Syrkin Wurtele

   Analysis of yeast, fly and human genomes suggests that sequence divergence is not the main source of orphan genes.
7. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Synteny-based analyses indicate that sequence divergence is not the main source of orphan genes

   Nikolaos Vakirlis et al.

   Homology information implicit in regions of conserved synteny allows quantification of gene origination by complete sequence divergence, revealing a larger-than-expected role for other mechanisms of origin, including de novo origination.
8. 1. Computational and Systems Biology

   Hidden long-range memories of growth and cycle speed correlate cell cycles in lineage trees

   Erika E Kuchen et al.

   The combination of statistical inference and perturbation experiments reveals that trans-generational inheritance of cell size and cell-cycle speed, coupled through a minimum-size checkpoint, shapes paradoxical cell-cycle correlations in lineage trees.
9. 1. Cell Biology
   2. Computational and Systems Biology

   Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling

   Christopher Edelmaier et al.
10. 1. Computational and Systems Biology

    Synthetic and genomic regulatory elements reveal aspects of cis-regulatory grammar in Mouse Embryonic Stem Cells

    Dana M King et al.