Computational and Systems Biology

Computational and Systems Biology

eLife publishes research involving the use of methods, models and software. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Computational and Systems Biology
    2. Neuroscience

    Self-configuring feedback loops for sensorimotor control

    Sergio Oscar Verduzco-Flores, Erik De Schutter
    Learning to reach in the sensorimotor loop, and the required neural dynamics, can be potentially explained by simple principles.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    T cell receptor convergence is an indicator of antigen-specific T cell response in cancer immunotherapies

    Mingyao Pan, Bo Li
    Amino acid codon degeneracy indicates antigen-specific selection of the T cell receptors and is predictive of cancer immunotherapy outcomes.
    Short Report Updated
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    1. Computational and Systems Biology
    2. Physics of Living Systems

    Landscape of epithelial–mesenchymal plasticity as an emergent property of coordinated teams in regulatory networks

    Kishore Hari, Varun Ullanat ... Mohit Kumar Jolly
    Investigation of regulatory network topology reveals latent design principles of multistable phenotypic landscape.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Transcriptome-wide association study and eQTL colocalization identify potentially causal genes responsible for human bone mineral density GWAS associations

    Basel Maher Al-Barghouthi, Will T Rosenow ... Charles R Farber
    Systems genetics approaches identify potentially causal bone mineral density genes.
    1. Computational and Systems Biology

    A tug of war between filament treadmilling and myosin induced contractility generates actin rings

    Qin Ni, Kaustubh Wagh ... Garegin A Papoian
    Actin networks form clusters under myosin-induced contractility, while high actin filament treadmilling speed can reshape actin networks into ring-like structures with lower mechanical energy.
    1. Computational and Systems Biology
    2. Neuroscience

    High-throughput automated methods for classical and operant conditioning of Drosophila larvae

    Elise C Croteau-Chonka, Michael S Clayton ... Kristina T Klein
    A novel high-throughput FPGA-based multi-animal tracking and training system was used to demonstrate trace and operant conditioning in Drosophila larvae.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Evolution and regulation of microbial secondary metabolism

    Guillem Santamaria, Chen Liao ... Joao B Xavier
    1. Computational and Systems Biology
    2. Neuroscience

    Mesoscale cortex-wide neural dynamics predict self-initiated actions in mice several seconds prior to movement

    Catalin Mitelut, Yongxu Zhang ... Timothy H Murphy
    Mouse self-initiated behaviors can be identified seconds prior to action and have similar neuro-dynamical structure to neural dynamics underlying human voluntary actions supporting the use of mouse models in self-initiated and volitional action research.

Senior editors

  1. Naama Barkai
    Naama Barkai
    Weizmann Institute of Science, Israel
  2. Christian R Landry
    Université Laval, Canada
  3. Aleksandra Walczak
    Ecole Normale Superieure, France
  4. See more editors