Computational and Systems Biology

Computational and Systems Biology

eLife reviews research involving the use of methods, models and software. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Computational and Systems Biology

    AI in Science: The 42 problem in AI-assisted research

    Giovanni Spitale, Federico Germani
    Large language models excel at producing answers, but an answer severed from its question and context may lack meaning.
    1. Neuroscience
    2. Computational and Systems Biology

    A theory-guided model maps four recurrent modes of fear-goal arbitration across learning and relapse in rats

    Bin Yin, Jiaojiao Rao, XT (XiaoTian) Wang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Phosphorylation and pocket-binding ligands rewire the coupled networks in multidomain protein condensate

    Yu Cao, Jinyu Chen, Xiakun Chu
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Computational and Systems Biology

    Penumbria: Advanced 3D cell segmentation for biomedical imaging

    Laurids Stockert, Joseph Donovan, Herwig Baier
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Obtaining maximum information from colony counts with REPOP

    Pedro Pessoa, Carol Yunxiao Slayton ... Steve Presse
    Conventional colony counting obscures bacterial population structure by conflating biological heterogeneity with stochastic noise from dilution and plating, which can be separated by explicitly modeling the measurement process.
    1. Computational and Systems Biology

    Role of desolvation on biomolecular liquid–liquid phase separation

    Kai Zhang, Zhiyu Peng ... Wei Wang
    A desolvation-aware coarse-grained framework enables efficient and physically realistic modeling of biomolecular phase separation by capturing water-mediated effects on phase behavior, dense-phase packing, conformational reorganization, and dynamics.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Out-of-balance Growth Enables Cost-free Synthesis of the Flagellum and Other Proteins in a Single Bacterium

    Mayra Garcia-Alcala, Josiah C Kratz, Philippe Cluzel
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Neuroscience
    2. Computational and Systems Biology

    Opposite and complementary roles of the two calcium thresholds for inducing LTP and LTD in models of striatal projection neurons

    Daniel Trpevski
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Evolutionary remodeling of non-canonical ORF translation in mammals

    Yue Chang, Tianyu Lei ... Hong Zhang
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    Uncertainty-aware quantitative analysis of the structure and dynamics of T cell receptor repertoires

    Simo Kitanovski, Kai Wollek, Daniel Hoffmann
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
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Highlights

    1. Computational and Systems Biology
    Stargazing. Image credit: @grakozy (CC0)

    The 42 problem in AI-assisted research

    Giovanni Spitale, Federico Germani
    1. Cell Biology
    2. Computational and Systems Biology
    Image credit: vividbiology.com

    The power of theory in the life sciences

    Jacob L Fine, Finn Creeggan ... Adam MR Groh
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Wnt Signaling: Exploring the origins of a signaling pathway

    Balaji Santhanam

Senior editors

  1. Alan Moses
    University of Toronto, Canada
  2. Aleksandra Walczak
    Ecole Normale Superieure, France
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