Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Leveraging the Mendelian disorders of the epigenetic machinery to systematically map functional epigenetic variation

   Teresa Romeo Luperchio et al.

   Chromatin/transcriptome profiling in multiple mouse models with mutations in epigenetic machinery (EM) reveals shared abnormalities including many IgA-relevant genes, indicating that this kind of joint analysis may elucidate the multigenic nature of EM disorders.
2. 1. Computational and Systems Biology
   2. Neuroscience

   Continuous attractors for dynamic memories

   Davide Spalla et al.

   A neural network model with asymmetric synaptic interactions can store and retrieve multiple continuous memory sequences with their temporal structure.
3. 1. Computational and Systems Biology
   2. Neuroscience

   Optimal plasticity for memory maintenance during ongoing synaptic change

   Dhruva Raman, Timothy O'Leary
4. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   Addressing shortfalls of laboratory HbA_1c using a model that incorporates red cell lifespan

   Yongjin Xu et al.

   The person-specific adjusted HbA_1c addresses non-glycaemic variation in laboratory HbA_1c due to red blood cell lifespan differences, potentially providing a better marker to predict diabetes complications and guide glycaemic management.
5. 1. Computational and Systems Biology
   2. Genetics and Genomics

   RNA splicing programs define tissue compartments and cell types at single cell resolution

   Julia Eve Olivieri et al.
6. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   MiSiC, a general deep learning-based method for the high-throughput cell segmentation of complex bacterial communities

   Swapnesh Panigrahi et al.
7. 1. Computational and Systems Biology
   2. Physics of Living Systems

   A simple regulatory architecture allows learning the statistical structure of a changing environment

   Stefan Landmann et al.

   Minimal modifications of common regulatory circuits can allow bacteria to learn from the past to better predict the future, on a physiological, rather than evolutionary, timescale.
8. 1. Cancer Biology
   2. Computational and Systems Biology

   Integrated evaluation of telomerase activation and telomere maintenance across cancer cell lines

   Kevin Hu et al.
9. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Information content differentiates enhancers from silencers in mouse photoreceptors

   Ryan Z Friedman et al.
10. 1. Computational and Systems Biology

    Environmental fluctuations reshape an unexpected diversity-disturbance relationship in a microbial community

    Christopher P Mancuso et al.