Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Developmental Biology

   Diversity in Notch ligand-receptor signaling interactions

   Rachael Kuintzle, Leah A Santat, Michael B Elowitz

   The Notch signaling pathway can use its various ligands, receptors, and Fringe proteins to generate diverse intra- and intercellular signaling behaviors.
2. 1. Neuroscience
   2. Computational and Systems Biology

   Self-association enhances early attentional selection through automatic prioritization of socially salient signals

   Meike Scheller, Jan Tünnermann ... Jie Sui
3. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Eco-evolutionary dynamics of adapting pathogens and host immunity

   Pierre Barrat-Charlaix, Richard A Neher

   Diverse histories of viral exposure, for example in individuals of different age, makes viral evolution less predictable with features of adaptive and neutral evolution.
4. 1. Computational and Systems Biology
   2. Medicine

   Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations

   Xin Zhou, Zhinuo Jenny Wang ... Blanca Rodriguez

   Human-based electromechanical simulations reveal electrocardiogram biomarkers are better indicators of pro-arrhythmic substrate after myocardial infarction than ejection fraction.
5. 1. Computational and Systems Biology

   Cellular Respiration: Mapping mitochondrial aging

   Alessandro Bitto

   Measuring mitochondrial respiration in frozen tissue samples provides the first comprehensive atlas of how aging affects mitochondrial function in mice.
6. 1. Computational and Systems Biology

   Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age

   Dylan C Sarver, Muzna Saqib ... G William Wong

   Mitochondrial respiration atlas reveals functional signatures of aging across diverse tissues and organ systems.
7. 1. Computational and Systems Biology

   Predicting the effect of CRISPR-Cas9-based epigenome editing

   Sanjit Singh Batra, Alan Cabrera ... Yun S Song
8. 1. Developmental Biology
   2. Computational and Systems Biology

   Dorsal/NF-κB exhibits a dorsal-to-ventral mobility gradient in the Drosophila embryo

   Hadel Al Asafen, Natalie M Clark ... Gregory T Reeves
9. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Overflow metabolism originates from growth optimization and cellheterogeneity

   Xin Wang
10. 1. Computational and Systems Biology

    Statistical analysis supports pervasive RNA subcellular localization and alternative 3' UTR regulation

    Rob Bierman, Jui M Dave ... Julia Salzman

    Analysis of genome-wide spatial transcriptomics data reveals cell-type specific subcellular RNA localization, and a subset of genes show significantly high correlation between spatial patterning and 3' UTR length.