Computational and Systems Biology

Computational and Systems Biology

eLife publishes research involving the use of methods, models and software. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Computational and Systems Biology
    2. Physics of Living Systems

    Macroscopic control of cell electrophysiology through ion channel expression

    Mario García-Navarrete, Merisa Avdovic ... Krzysztof Wabnik
    A combination of mathematical modeling and live-cell imaging reveals a strategy for the rational control over cell electrophysiology though modulation of ion channel expression.
    1. Computational and Systems Biology
    2. Developmental Biology

    Deep proteome profiling reveals signatures of age and sex differences in paw skin and sciatic nerve of naïve mice

    Feng Xian, Julia Regina Sondermann ... Manuela Schmidt
    Proteomics uncovers thus far unknown age and sex differences in sciatic nerve and skin of naïve mice, highlighting the importance of adequate age matching and parallel investigation of male and female mice in biomedical studies.
    1. Cancer Biology
    2. Computational and Systems Biology

    Single-cell transcriptomics identifies Keap1-Nrf2 regulated collective invasion in a Drosophila tumor model

    Deeptiman Chatterjee, Caique Almeida Machado Costa ... Wu-Min Deng
    Comprehensive transcriptomic analyses describe the underlying tumorigenic gene expression state in the invasive Drosophila follicle cells following the loss of epithelial cell polarity and identify a non-canonical role of Keap1-Nrf2 signaling in regulating collective cell invasion.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Evolution and regulation of microbial secondary metabolism

    Guillem Santamaria, Chen Liao ... Joao B Xavier
    Strains of the bacterium Pseudomonas aeruginosa that use secondary metabolism to make surfactants and change the surface tension of the liquid that surrounds them do so only if they can first meet their primary metabolic needs.
    1. Computational and Systems Biology
    2. Developmental Biology

    Large-scale analysis and computer modeling reveal hidden regularities behind variability of cell division patterns in Arabidopsis thaliana embryogenesis

    Elise Laruelle, Katia Belcram ... Philippe Andrey
    Self-organization based on a feedback loop between cell geometry and division plane positioning plays a central role in the building of tissue architectures in Arabidopsis thaliana embryo through both stereotyped and variable division patterns.
    1. Computational and Systems Biology
    2. Neuroscience

    Self-configuring feedback loops for sensorimotor control

    Sergio Oscar Verduzco-Flores, Erik De Schutter
    Learning to reach in the sensorimotor loop, and the required neural dynamics, can be potentially explained by simple principles.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    T cell receptor convergence is an indicator of antigen-specific T cell response in cancer immunotherapies

    Mingyao Pan, Bo Li
    Amino acid codon degeneracy indicates antigen-specific selection of the T cell receptors and is predictive of cancer immunotherapy outcomes.
    Short Report Updated
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Senior editors

  1. Naama Barkai
    Naama Barkai
    Weizmann Institute of Science, Israel
  2. Christian R Landry
    Université Laval, Canada
  3. Aleksandra Walczak
    Ecole Normale Superieure, France
  4. See more editors