Computational and Systems Biology

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila

   Luke Stephen Tain et al.

   Multi-omic profiling of gene expression in response to reduced insulin/IGF-like-signalling reveals tissue-specific regulation of DNA damage and lysosomal mannosidase regulation of tissue homeostasis as pro-longevity responses.
2. 1. Computational and Systems Biology
   2. Neuroscience

   Visuomotor learning from postdictive motor error

   Jana Masselink, Markus Lappe

   Visual, motor, and forward model gains learn from a postdictive update of space to keep perception and saccadic motor function aligned.
3. 1. Computational and Systems Biology
   2. Stem Cells and Regenerative Medicine

   The biphasic and age-dependent impact of Klotho on hallmarks of aging and skeletal muscle function

   Zachary Clemens et al.
4. 1. Computational and Systems Biology

   A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice.

   Michael A Petr et al.
5. 1. Computational and Systems Biology
   2. Ecology

   Nutrient dominance governs the assembly of microbial communities in mixed nutrient environments

   Sylvie Estrela et al.

   There are regularities in how specific nutrients combine together to shape the taxonomic composition of self-assembled communities, with some types of nutrients dominating other types.
6. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Downregulation of glial genes involved in synaptic function mitigates Huntington's Disease pathogenesis

   Tarik Seref Onur et al.
7. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses

   Stephan Wilmes et al.
8. 1. Computational and Systems Biology

   A convolutional neural network for the prediction and forward design of ribozyme-based gene-control elements

   Calvin M Schmidt, Christina D Smolke
9. 1. Computational and Systems Biology

   Mouse aging cell atlas analysis reveals global and cell type-specific aging signatures

   Martin Jinye Zhang et al.

   Comprehensive single-cell transcriptome analysis reveals global and tissue-specific aging markers and characterizes the heterogeneous aging status of different cell types and tissues in mouse.
10. 1. Computational and Systems Biology
    2. Neuroscience

    Action detection using a neural network elucidates the genetics of mouse grooming behavior

    Brian Q Geuther et al.

    A machine learning method for action detection is developed and applied toward mouse grooming behavior.