Computational and Systems Biology

Computational and Systems Biology

eLife publishes research involving the use of methods, models and software. Learn more about what we publish and sign up for the latest research.
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Latest articles

    1. Computational and Systems Biology
    2. Genetics and Genomics

    Detecting adaptive introgression in human evolution using convolutional neural networks

    Graham Gower et al.
    Convolutional neural networks are an effective tool for detecting archaic adaptive introgression from genomic data.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Bacterial death and TRADD-N domains help define novel apoptosis and immunity mechanisms shared by prokaryotes and metazoans

    Gurmeet Kaur et al.
    Prokaryotic TRADD-N and Death-like adaptor domains in diverse predicted apoptosis and immune systems from multicellular prokaryotes and metazoans indicate the common origin of key apoptosis mechanisms required for the stabilization of multicellularity.
    1. Computational and Systems Biology
    2. Medicine

    Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarction

    Muhammad Arif et al.
    Elucidating widespread and tissue-specific biological process alterations after myocardial infaction in metabolically active tissues using systems biology approaches.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    The push-to-open mechanism of the tethered mechanosensitive ion channel NompC

    Yang Wang et al.
    A pushing force on the ankyrin repeat region of NompC leads to the gating of the mechanosensitive ion channel, which may enable cells to feel compression and shrinkage.
    1. Computational and Systems Biology
    2. Medicine

    Heart Attack: Working together

    Regan Odongo, Tunahan Çakır
    Heart attacks have a ripple effect on how other organs exchange biomolecules that help the heart respond to injury.
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    1. Computational and Systems Biology
    2. Plant Biology

    An ABA-GA bistable switch can account for natural variation in the variability of Arabidopsis seed germination time

    Katie Abley et al.
    Arabidopsis shows extensive genetic diversity in germination time distributions, which can be explained by the underlying ABA/GA network functioning as a noisy bistable switch.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis

    Tarik Seref Onur et al.
    Cross-species transcriptomic analysis and high-throughput behavioral assays in a Drosophila model of Huntington's disease show that downregulation of glial genes involved in synaptic function compensates for disease-related excitotoxicity.

Senior editors

  1. Naama Barkai
    Naama Barkai
    Weizmann Institute of Science, Israel
  2. Aleksandra Walczak
    Ecole Normale Superieure, France
  3. Patricia Wittkopp
    University of Michigan, United States
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