Computational and Systems Biology

Computational and Systems Biology

eLife reviews research involving the use of methods, models and software. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Computational and Systems Biology

    Genetics: From mouse to human

    Arya Mani
    A deep analysis of multiple genomic datasets reveals which genetic pathways associated with atherosclerosis and coronary artery disease are shared between mice and humans.
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    1. Computational and Systems Biology

    Shared and distinct pathways and networks genetically linked to coronary artery disease between human and mouse

    Zeyneb Kurt, Jenny Cheng ... Xia Yang
    Cross-species multiomics network modeling revealed tissue-specific regulatory genes, pathways, and networks shared between mouse and human or unique to each species for atherosclerosis and coronary artery disease.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to antifungal compounds

    Vanessa Dumeaux, Samira Massahi ... Michael T Hallett
    Candida albicans cells respond in two distinct ways to fluconazole exposure where cells enter the Ribo-dominant state characterized by an upregulation of ribosomal-related proteins and processes, or cells enter the Stress-dominant state characterized by the upregulation of stress responses.
    1. Computational and Systems Biology

    Detection of new pioneer transcription factors as cell-type specific nucleosome binders

    Yunhui Peng, Wei Song ... Anna R. Panchenko
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Quantitative analyses of T cell motion in tissue reveals factors driving T cell search in tissues

    David J Torres, Paulus Mrass ... Judy L Cannon
    The analysis of T cell movement in multiple tissues (lymph node, villi, and lung under two different inflammatory conditions) sheds new light on how T cells navigate different tissue environments to improve immunity and search processes.

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  1. Christian R Landry
    Université Laval, Canada
  2. Alan Moses
    University of Toronto, Canada
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    Ecole Normale Superieure, France
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