Computational and Systems Biology

Computational and Systems Biology

eLife reviews research involving the use of methods, models and software. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Computational and Systems Biology
    2. Genetics and Genomics

    Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophy

    Karthickeyan Chella Krishnan, Elie-Julien El Hachem ... Aldons J Lusis
    The discovery of three distinct and independent trans-regulating genomic loci influencing heart mass using a well-characterized mouse reference population provides evidence in support of the hypothesis that genetic diversity in the mitochondrial proteome plays a critical role in heart pathophysiology.
    1. Computational and Systems Biology

    Shared enhancer gene regulatory networks between wound and oncogenic programs

    Swann Floc'hlay, Ramya Balaji ... Stein Aerts
    Single-cell multiomics reveals the gene regulatory networks and enhancer logic underlying two distinct wound response cell states in the Drosophila wing imaginal disc and finds similarities with cell states observed in the Ras-scrib tumor model.
    1. Cancer Biology
    2. Computational and Systems Biology

    Comprehensive characterization of tumor microenvironment in colorectal cancer via molecular analysis

    Xiangkun Wu, Hong Yan ... Li Liang
    Integrated molecular analysis demonstrated that colorectal cancer can be classified into four molecular subtypes (proliferative, immunomodulatory, immunosuppressed, and immune-excluded subtypes), providing valuable insight into the intricate relationship between tumor microenvironment heterogeneity and various clinical phenotypes.
    1. Computational and Systems Biology
    2. Neuroscience

    Dissecting muscle synergies in the task space

    David Ó’ Reilly, Ioannis Delis
    1. Cancer Biology
    2. Computational and Systems Biology

    GENIUS: GEnome traNsformatIon and spatial representation of mUltiomicS data

    Mateo Sokač, Lars Dyrskjøt ... Nicolai J Birkbak

Senior editors

  1. Christian R Landry
    Université Laval, Canada
  2. Aleksandra Walczak
    Ecole Normale Superieure, France
  3. See more editors