Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology

   Single-molecule behavior and cell-growth regulation in human RTKs

   Mitsuhiro Abe, Masataka Yanagawa ... Yasushi Sako
2. 1. Neuroscience
   2. Computational and Systems Biology

   Where is the melody? Spontaneous attention orchestrates melody formation during polyphonic music listening

   Martin M Winchester, Kevin Reynolds ... Giovanni M Di Liberto
3. 1. Genetics and Genomics
   2. Computational and Systems Biology

   Massively Parallel Polyribosome Profiling Reveals Translation Defects of Human Disease-Relevant UTR Mutations

   Jia-Ying Su, Wei-Ping Li ... Chien-Ling Lin
4. 1. Microbiology and Infectious Disease
   2. Computational and Systems Biology

   High-dimensional Characterization of Genome–Environment Fitness Landscapes in Klebsiella pneumoniae

   Ge Zhou, Georgia Williams ... Danesh Moradigaravand
5. 1. Neuroscience
   2. Computational and Systems Biology

   Global Nernstian astrocytic depolarization breaks down during local synaptic input

   Ryo J Nakatani, Erik De Schutter
6. 1. Computational and Systems Biology
   2. Cancer Biology

   Heterogeneous, population-level drug-tolerant persisters exhibit ion-channel remodeling and ferroptosis susceptibility

   Corey E Hayford, Blake Baleami ... Leonard A Harris
7. 1. Computational and Systems Biology

   Knockdown of a regulatory barcode shifts macrophage polarization destination from M1 to M2 and increases pathogen burden upon S. aureus infection

   Sathyabaarathi Ravichandran, Bharath Bhatt ... Nagasuma Chandra

   A combination of three transcriptional regulators (CEBPB, NFE2L2, and BCL3) can shift macrophages from an M1 to an M2 phenotype, altering their susceptibility to bacterial infection.
8. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Quantifying microbial fitness in high-throughput experiments

   Justus Wilhelm Fink, Michael Manhart

   The choice of fitness metric is crucial in microbial ecology—commonly chosen metrics lead to different results that may affect the conclusions from pairwise competition assays and high-throughput genetic screens.
9. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   Calibrated analysis framework for nanopore direct RNA sequencing uncovers cell-specific m⁶A proportions at conserved sites

   Denise Ohnezeit, Elene Loliashvili ... Angus C Wilson
10. 1. Computational and Systems Biology
    2. Physics of Living Systems

    Out-of-balance growth enables cost-free synthesis of the flagellum and other proteins in a single bacterium

    Mayra Patricia Garcia Alcala, Josiah C Kratz, Philippe Cluzel

    Surprisingly, monitoring single bacteria expressing constitutive or flagellar genes reveals faster growth, a benefit driven by inherited, cost-free growth factors, whereas bulk measurements show an expected net fitness cost.