Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Proteome-wide signatures of function in highly diverged intrinsically disordered regions

   Taraneh Zarin et al.

   Widespread, rapidly evolving disordered regions contain molecular features that are preserved over evolution and are associated with specific biological functions.
2. 1. Computational and Systems Biology
   2. Neuroscience

   A quantitative model of conserved macroscopic dynamics predicts future motor commands

   Connor Brennan, Alexander Proekt

   Calcium imaging is used to construct a model of Caenorhabditis elegans nervous system dynamics capable of predicting future behavioral switches on a trial by trial basis and across individual animals.
3. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Unified single-cell analysis of testis gene regulation and pathology in five mouse strains

   Min Jung et al.

   A statistical method for summarizing single-cell gene expression data identifies normal and disease-specific transcriptional programs from an atlas of 57,600 cells.
4. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq

   Dylan Kotliar et al.
5. 1. Computational and Systems Biology

   Metabolic network percolation quantifies biosynthetic capabilities across the human oral microbiome

   David B Bernstein et al.

   A novel metabolic network analysis method enables large-scale computational predictions of biosynthetic capabilities across the human oral microbiome, revealing a unique cluster of fastidious microorganisms and potential metabolic interdependencies.
6. 1. Computational and Systems Biology
   2. Neuroscience

   Front-end Weber-Fechner gain control enhances the fidelity of combinatorial odor coding

   Nirag Kadakia, Thierry Emonet

   In multi-channel sensory systems, gain adaptation can help maintain not only coding capacity across changes in signal intensity, but also combinatorial representations of odor identity.
7. 1. Computational and Systems Biology

   Meta-Research: Centralized scientific communities are less likely to generate replicable results

   Valentin Danchev et al.

   Analysis of data on drug-gene interactions suggests that decentralized collaboration will increase the robustness of scientific findings in biomedical research.
8. 1. Computational and Systems Biology
   2. Structural Biology and Molecular Biophysics

   Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation

   Jamie A Macpherson et al.
9. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   Dissecting the sharp response of a canonical developmental enhancer reveals multiple sources of cooperativity

   Jeehae Park et al.

   The sharp expression pattern driven by a classic, simple animal enhancer is determined by multiple molecular mechanisms, not only cooperative binding of the activating transcription factor as was previously thought.
10. 1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Response to comment on 'Valid molecular dynamics simulations of human hemoglobin require a surprisingly large box size'

    Krystel El Hage et al.

    We are writing to respond to the comment by Gapsys and de Groot, 2019 on our article about molecular dynamics simulations of human hemoglobin (El Hage et al., 2018).