Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Wnt Signaling: Exploring the origins of a signaling pathway

   Balaji Santhanam

   The 19 Wnt proteins found in humans are part of a larger superfamily of proteins that are also found in Archaea and Bacteria.
2. 1. Neuroscience
   2. Computational and Systems Biology

   The electrogenicity of the Na⁺/K⁺-ATPase poses challenges for computation in highly active spiking cells

   Liz Weerdmeester, Jan-Hendrik Schleimer, Susanne Schreiber
3. 1. Genetics and Genomics
   2. Computational and Systems Biology

   Massively Parallel Polyribosome Profiling Reveals Translation Defects of Human Disease-Relevant UTR Mutations

   Wei-Ping Li, Jia-Ying Su ... Chien-Ling Lin
4. 1. Cancer Biology
   2. Computational and Systems Biology

   Altered thymic niche synergistically drives the massive proliferation of malignant thymocytes

   Erika Tsingos, Advaita M Dick, Baubak Bajoghli

   Combining computer modeling and experiments in animals shows that the spatial organization of thymic epithelial cells affects the availability of signaling molecules that regulate thymocyte proliferation and development.
5. 1. Immunology and Inflammation
   2. Computational and Systems Biology

   Restoring data balance via generative models of T cell receptors for antigen-binding prediction

   Emanuele Loffredo, Mauro Pastore ... Rémi Monasson
6. 1. Computational and Systems Biology

   Anatomical basis of sex differences in the electrocardiogram identified by three-dimensional torso-heart imaging reconstruction pipeline

   Hannah J Smith, Blanca Rodriguez ... Abhirup Banerjee
7. 1. Computational and Systems Biology
   2. Neuroscience

   Accept–reject decision-making revealed via a quantitative and ethological study of C. elegans foraging

   Jessica A Haley, Tianyi Chen ... Sreekanth H Chalasani

   C. elegans foraging decisions are guided by learned environmental features, integrating recent patch quality with internal satiety to balance exploration and exploitation.
8. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   The flexible stalk domain of sTREM2 modulates its interactions with brain-based phospholipids

   David Saeb, Emma E Lietzke ... Kayla G Sprenger

   The flexible stalk region of sTREM2 binds the Ig-like domain, altering stability and ligand accessibility—a biochemically testable mechanism with broad implications for (s)TREM2 biology and rational Alzheimer's disease therapeutic design.
9. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Alternative Splicing Across the Tree of Life: A Comparative Study

   Rebeca de la Fuente, Wladimiro Díaz-Villanueva ... Andrés Moya
10. 1. Computational and Systems Biology

    OpenSpliceAI: An efficient, modular implementation of SpliceAI enabling easy retraining on non-human species

    Kuan-Hao Chao, Alan Mao ... Mihaela Pertea