Computational and Systems Biology

Computational and Systems Biology

eLife publishes research involving the use of methods, models and software. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cancer Biology
    2. Computational and Systems Biology

    Proteogenomic analysis of cancer aneuploidy and normal tissues reveals divergent modes of gene regulation across cellular pathways

    Pan Cheng, Xin Zhao ... Teresa Davoli
    RNA-level regulation of gene expression is negatively associated with protein-level regulation across cellular pathways in normal tissues and cancer.
    1. Computational and Systems Biology
    2. Neuroscience

    Allosteric stabilization of calcium and phosphoinositide dual binding engages several synaptotagmins in fast exocytosis

    Janus RL Kobbersmed, Manon MM Berns ... Alexander M Walter
    A mathematical model of neurotransmitter release predicts that a mutual stabilization of calcium and membrane phospholipids binding to synaptotagmin proteins allows several synaptotagmins to work together for fast synaptic transmission.
    1. Computational and Systems Biology

    Network design principle for robust oscillatory behaviors with respect to biological noise

    Lingxia Qiao, Zhi-Bo Zhang ... Lei Zhang
    Searching all two- and three-node gene regulatory network topologies identifies the repressilator with positive autoregulation as the motif capable of accurate oscillation and reveals the long period and high amplitude as two distinct mechanisms for buffering different noise.
    1. Computational and Systems Biology
    2. Neuroscience

    Contribution of behavioural variability to representational drift

    Sadra Sadeh, Claudia Clopath
    By analysing large-scale datasets from the Allen Brain Observatory, we found that changes in the behavioural state of the animal can significantly contribute to the changes in representational similarity over time.
    1. Computational and Systems Biology
    2. Neuroscience

    Reverse engineering of metacognition

    Matthias Guggenmos
    A model framework and toolbox to quantify metacognitive biases and sources of metacognitive noise in animal and human confidence data.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Eco-evolutionary dynamics of clonal multicellular life cycles

    Vanessa Ress, Arne Traulsen, Yuriy Pichugin
    The evolution of clonal multicellular life cycles, whose growth is constrained by competition, may lead to coexistence or multistability between several life cycles while evolutionarily stable strategies can be inferred from the analysis of a model with unconstrained growth.
    1. Cell Biology
    2. Computational and Systems Biology

    A unified view of low complexity regions (LCRs) across species

    Byron Lee, Nima Jaberi-Lashkari, Eliezer Calo
    Disparate functions of low complexity regions of proteins can be understood through a global view of their sequences, features, and relationships across different organisms and biological contexts.
    1. Computational and Systems Biology
    2. Neuroscience

    Automatically tracking feeding behavior in populations of foraging C. elegans

    Elsa Bonnard, Jun Liu ... Monika Scholz
    A new tool enables measuring feeding and locomotion simultaneously which will enable insights into environmental, developmental, neuronal, and genetic factors underlying behavioral regulation.

Senior editors

  1. Naama Barkai
    Naama Barkai
    Weizmann Institute of Science, Israel
  2. Christian R Landry
    Université Laval, Canada
  3. Aleksandra Walczak
    Ecole Normale Superieure, France
  4. See more editors