Computational and Systems Biology

Computational and Systems Biology

eLife reviews research involving the use of methods, models and software. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Computational and Systems Biology
    2. Evolutionary Biology

    Autotrophic growth of Escherichia coli is achieved by a small number of genetic changes

    Roee Ben Nissan, Eliya Milshtein ... Ron Milo
    Achieving autotrophy in E. coli by introducing a small number of genetic changes crosses a milestone in engineering major metabolic transitions and paves a way for sustainable bio-production from CO2.
    1. Computational and Systems Biology

    Spatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification

    Tae-Yun Kang, Federico Bocci ... Andre Levchenko
    The transition from a restrictive patterning mechanism to one sensitive to a variety of environmental cues in NOTCH-mediated angiogenesis offers crucial insights into vascularization in damaged organs and cancer therapy.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    How microscopic epistasis and clonal interference shape the fitness trajectory in a spin glass model of microbial long-term evolution

    Nicholas M Boffi, Yipei Guo ... Ariel Amir
    High-resolution simulations of evolving microbial populations reveal that microscopic epistasis slows the rate of adaptation, while clonal interference can either speed it up or leave it fixed.
    1. Computational and Systems Biology

    Repurposing the mammalian RNA-binding protein Musashi-1 as an allosteric translation repressor in bacteria

    Roswitha Dolcemascolo, María Heras-Hernández ... Guillermo Rodrigo
    A mammalian protein with RNA recognition motifs can be used in bacteria to engineer post-transcriptional regulation.
    1. Computational and Systems Biology

    AI-driven Automated Discovery Tools Reveal Diverse Behavioral Competencies of Biological Networks

    Mayalen Etcheverry, Clément Moulin-Frier ... Michael Levin
    1. Computational and Systems Biology
    2. Neuroscience

    A dynamical computational model of theta generation in hippocampal circuits to study theta-gamma oscillations during neurostimulation

    Nikolaos Vardalakis, Amélie Aussel ... Fabien B Wagner
    Combining biophysically realistic hippocampal neurons with coupled phase oscillators that represent theta inputs enables probing the phase-dependent effects of neurostimulation on theta-nested gamma oscillations in normal and pathological states.
    1. Computational and Systems Biology

    Structural assembly of the bacterial essential interactome

    Jordi Gómez Borrego, Marc Torrent Burgas
    A new study reveals structural details of the bacterial essential interactome, opening new avenues for antibiotic discovery.