Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Neuroscience

   Subunit exchange enhances information retention by CaMKII in dendritic spines

   Dilawar Singh, Upinder Singh Bhalla

   Due to subunit-exchange, CaMKII can store information at diverse time-scales and might play a central role in the memory maintenance.
2. 1. Computational and Systems Biology
   2. Genetics and Genomics

   A new experimental platform facilitates assessment of the transcriptional and chromatin landscapes of aging yeast

   David G Hendrickson et al.

   A new technology for obtaining aged yeast cells helps reveal a striking connection between aging, slow growth, and stress.
3. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Life Expectancy: Advancing the aging biology toolkit

   Troy K Coody, Adam L Hughes

   A new device for isolating large quantities of old yeast cells expands the experimental boundaries of aging research.
4. 1. Computational and Systems Biology
   2. Neuroscience

   A kinematic synergy for terrestrial locomotion shared by mammals and birds

   Giovanna Catavitello et al.

   General principles of the limb segment control for terrestrial locomotion have emerged in evolution and highlight the existence of the laws of biological motion that apply to various animal species.
5. 1. Computational and Systems Biology
   2. Developmental Biology

   A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment

   Kenneth KH Ng et al.

   The timing and outcome of mammalian cell lineage decisions can be controlled by slow, stochastic events on individual regulatory gene loci.
6. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   Genome-wide Estrogen Receptor-α activation is sustained, not cyclical

   Andrew N Holding et al.
7. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   Integrated culturing, modeling and transcriptomics uncovers complex interactions and emergent behavior in a three-species synthetic gut community

   Kevin D'hoe et al.

   Human gut bacteria alter their metabolism in response to each other's presence, which causes their community dynamics to deviate from predictions that are based on mono-culture data.
8. 1. Computational and Systems Biology
   2. Neuroscience

   Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model

   Daniel B Dorman et al.

   Inhibition enhances the spatial specificity of high calcium influx for cooperatively stimulated synapses, suggesting that inhibitory inputs may regulate both synapse-specific and heterosynaptic plasticity to support learning and memory.
9. 1. Computational and Systems Biology
   2. Developmental Biology

   Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression

   C Matthew Hope et al.

   Tuned protein–protein interaction affinity optimizes the repressive function of the ETS family transcription factor Yan in order to contribute specificity and robustness to cell fate specification in the developing Drosophila eye.
10. 1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Simulation of spontaneous G protein activation reveals a new intermediate driving GDP unbinding

    Xianqiang Sun et al.

    Combining powerful simulation methods uncovers the structural and dynamical changes driving G protein activation in atomic detail, revealing the allosteric network that triggers GDP release and reconciling diverse experimental data.