Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Deciphering the combinatorial landscape of immunity

   Antonio Cappuccio et al.
2. 1. Computational and Systems Biology
   2. Neuroscience

   Neuronal timescales are functionally dynamic and shaped by cortical microarchitecture

   Richard Gao et al.
3. 1. Computational and Systems Biology
   2. Epidemiology and Global Health

   Plasma proteomic biomarker signature of age predicts health and life span

   Toshiko Tanaka et al.
4. 1. Computational and Systems Biology
   2. Neuroscience

   Bayesian inference for biophysical neuron models enables stimulus optimization for retinal neuroprosthetics

   Jonathan Oesterle et al.

   Bayesian simulator-based inference is used to infer the parameters of complex multicompartment models of retinal neurons from two-photon imaging data.
5. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   Spatially compartmentalized phase regulation of a Ca²⁺-cAMP-PKA oscillatory circuit

   Brian Tenner et al.

   Nanodomain clustering of cAMP effectors represents a novel mechanism of cAMP compartmentation within an oscillatory signaling circuit.
6. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   Nanoscale Signaling: Messages across time and space

   Sascha M Kuhn, André Nadler

   Compartmentalized oscillations of second messengers affect global cellular signaling.
7. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Cytotoxic T cells swarm by homotypic chemokine signalling

   Jorge Luis Galeano Niño et al.

   Killer T cells swarm around tumour targets by accelerating the recruitment of distant T cells, which upon arrival and target engagement augment the chemotactic signal in a positive feedback loop.
8. 1. Computational and Systems Biology
   2. Genetics and Genomics

   A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin

   Morgan Levine et al.

   The first epigenetic clock for rats was developed and revealed to reflect phenotypic aging and captured the effects of longevity interventions.
9. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Evolution of multicellularity by collective integration of spatial information

   Enrico Sandro Colizzi et al.

   Selection for undifferentiated multicellularity emerges in an evolutionary cell-based model because a collective of cells performs chemotaxis better than single cells in a noisy environment.
10. 1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Investigating the trade-off between folding and function in a multidomain Y-family DNA polymerase

    Xiakun Chu et al.

    The physical interaction network encoded in the multi-domain protein native structure handles the trade-off between the fast, stable folding and the efficient, reliable function.