Computational and Systems Biology

Latest articles

1. 1. Genetics and Genomics
   2. Computational and Systems Biology

   Human-specific lncRNAs contributed critically to human evolution by distinctly regulating gene expression

   Jie Lin, Yujian Wen ... Hao Zhu
2. 1. Computational and Systems Biology
   2. Cancer Biology

   Altered thymic niche synergistically drives the massive proliferation of malignant thymocytes

   Erika Tsingos, Advaita M Dick, Baubak Bajoghli
3. 1. Immunology and Inflammation
   2. Computational and Systems Biology

   Thrifty wide-context models of B cell receptor somatic hypermutation

   Kevin Sung, Mackenzie M Johnson ... Frederick A Matsen
4. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   Real-time transcriptomic profiling in distinct experimental conditions

   Tamer Butto, Stefan Pastore ... Susanne Gerber
5. 1. Computational and Systems Biology
   2. Physics of Living Systems

   A mathematical model for ketosis-prone diabetes suggests the existence of multiple pancreatic β-cell inactivation mechanisms

   Sean A Ridout, Priyathama Vellanki, Ilya Nemenman

   A simple mathematical model, incorporating reversible deactivation of β-cells, can potentially explain the rapid onset and remission of a diabetes subtype, ketosis-prone diabetes.
6. 1. Developmental Biology
   2. Computational and Systems Biology

   A quantitative pipeline for whole-mount deep imaging and analysis of multi-layered organoids across scales

   Alice Gros, Jules Vanaret ... Sham Tlili
7. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   Molecular Landscape of the Mouse Adrenal Gland and Adjacent Adipose by Spatial Transcriptomics

   Małgorzata Blatkiewicz, Szymon Hryhorowicz ... Marcin Rucinski
8. 1. Computational and Systems Biology

   Ribosome demand links transcriptional bursts to protein expression noise

   Sampriti Pal, Upasana Ray, Riddhiman Dhar
9. 1. Computational and Systems Biology
   2. Neuroscience

   Self-other generalisation shapes social interaction and is disrupted in borderline personality disorder

   Joseph M Barnby, Jen Nguyen ... London Personality and Mood Disorders Consortium

   Individuals with borderline personality disorder maintain rigid, distinct self-other representations, disrupting the bidirectional generalisation that underpins adaptive social learning and interpersonal trust.
10. 1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Pan-tissue Transcriptome Analysis Reveals Sex-dimorphic Human Aging

    Siqi Wang, Danyue Dong ... Zefeng Wang