Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   Initiation of chromosome replication controls both division and replication cycles in E. coli through a double-adder mechanism

   Guillaume Witz et al.
2. 1. Cancer Biology
   2. Computational and Systems Biology

   Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome

   Amanda B Abildgaard et al.

   Biophysical modeling, performed in silico, can predict the abundance, metabolic stability, and function of MLH1 inside living cells.
3. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Adaptation to mutational inactivation of an essential gene converges to an accessible suboptimal fitness peak

   João V Rodrigues, Eugene I Shakhnovich

   When an essential metabolic gene in E. coli is mutationally inactivated, subsequent evolution rarely reverts the mutation to wild type but rather follows unexpected paths that rewire metabolic fluxes.
4. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   Bacterial survival in microscopic surface wetness

   Maor Grinberg et al.

   A new intricate reciprocity between microbiology and physics results in collective protection from desiccation through differential formation of stable microdroplets around bacterial aggregates on surfaces drying under moderate humidity.
5. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   Bacterial Survival: Life on a leaf

   Robin Tecon

   Microscopic water films allow bacteria to survive the seemingly dry surface of plant leaves.
6. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humans

   Murilo Delgobo et al.

   Mycobacterium tuberculosis exploits an IFN/IL6/CEBP axis linked to monocyte expansion in humans.
7. 1. Computational and Systems Biology
   2. Epidemiology and Global Health

   Modeling the dynamics of Plasmodium falciparum gametocytes in humans during malaria infection

   Pengxing Cao et al.

   A mathematical model of blood-stage infection with Plasmodium falciparum malaria capturing the sexual stage of the parasite life-cycle is validated against human data, providing new insight into human-to-mosquito transmission.
8. 1. Computational and Systems Biology
   2. Evolutionary Biology

   ASPEN, a methodology for reconstructing protein evolution with improved accuracy using ensemble models

   Roman Sloutsky, Kristen M Naegle

   Using different sets of input sequences to evolutionary reconstruction algorithms results in the exploration of many possible models, the intergration over which produces significantly more accurate models.
9. 1. Computational and Systems Biology
   2. Stem Cells and Regenerative Medicine

   Self-assembling manifolds in single-cell RNA sequencing data

   Alexander J Tarashansky et al.

   An iterative self-assembling algorithm identifies the intrinsic structures in single-cell transcriptomic data and helps to discover new cell populations that are undetectable by existing methods.
10. 1. Computational and Systems Biology
    2. Neuroscience

    Rats exhibit similar biases in foraging and intertemporal choice tasks

    Gary A Kane et al.

    In both foraging and intertemporal choice tasks, rats prefer immediate rewards to delayed rewards, and this preference can be explained by a form of hyperbolic discounting.