Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Neuroscience

   Opening the black box toward a modular approach to spike sorting

   Samuel Garcia, Chris Halcrow ... Pierre Yger

   Modularized spike sorting pipelines can identify performance bottlenecks, lower contribution barriers, and enable the development of highly accurate algorithms to turn extracellular recordings into spikes.
2. 1. Computational and Systems Biology
   2. Neuroscience

   Real-time closed-loop feedback system for mouse mesoscale cortical signal and movement control

   Pankaj Kumar Gupta, Timothy H Murphy

   The open-source closed-loop system enables mice to learn modulation of cortical activity or movement by providing a platform for testing brain-behavior relationships in motor learning and neurorehabilitation research.
3. 1. Computational and Systems Biology
   2. Cancer Biology

   MicroRNA spatial profiling for assessing drug efficacy in BRCA1-related triple-negative breast tumors

   Omar N Mohd, Lin Wang ... Patrick S Doyle
4. 1. Computational and Systems Biology

   Role of desolvation on biomolecular liquid-liquid phase separation

   Kai Zhang, Zhiyu Peng ... Wei Wang
5. 1. Genetics and Genomics
   2. Computational and Systems Biology

   Imputation of structural variants using a multi-ancestry long-read sequencing panel enables identification of disease associations

   Boris Noyvert, A Mesut Erzurumluoglu ... Zhihao Ding
6. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Linear antibody epitope prediction using AlphaFold2

   Jacob DeRoo, James S Terry ... Brian J Geiss

   AlphaFold2 can be used to accurately determine linear epitopes of antibodies with known heavy and light chain sequences.
7. 1. Cell Biology
   2. Computational and Systems Biology

   Philosophy of Biology: The power of theory in the life sciences

   Jacob L Fine, Finn Creeggan ... Adam MR Groh

   Theory can help address cell and molecular biology’s major challenges, particularly those arising from large omics datasets.
8. 1. Computational and Systems Biology

   Predicting dynamic expression patterns in budding yeast with a fungal DNA language model

   Kuan-Hao Chao, Majed Mohamed Magzoub ... David R Kelley
9. 1. Computational and Systems Biology

   Comprehensive RNA velocity by modeling the cascade of gene regulation, transcription, and splicing from single-cell RNA sequencing data with TSvelo

   Jiachen Li, Zhe Wang ... Ye Yuan

   TSvelo provides a comprehensive RNA velocity mathematics framework that can model the cascade of gene regulation, transcription, and splicing.
10. 1. Microbiology and Infectious Disease
    2. Computational and Systems Biology

    A new diagnostic modality for bovine tuberculosis: accurate and robust classification of infected cattle using transcriptomics and machine learning

    John F O’Grady, Adriana Ivich ... David E MacHugh