Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Physics of Living Systems

   An engineered multi-step differentiation program in Escherichia coli for self-organized spatial patterning

   Emanuele Boni, Hélène Siboulet ... Yolanda Schaerli
2. 1. Computational and Systems Biology

   A real-time, multi-animal model for automatic face detection and identification of freely moving common marmosets based on YOLOv8 algorithms

   Jiayue Yang, James Wang, Justine Cléry

   A generalizable computational approach automatically identifies individual common marmosets to serve as support for presenting and analyzing behavioral tasks without relying on extensive manual work.
3. 1. Computational and Systems Biology
   2. Developmental Biology

   Single-cell spatial mapping reveals reproducible cell type organization and spatially dependent gene expression in gastruloids

   Catherine Triandafillou, Pranav Sompalle ... Arjun Raj

   Detailed, single-cell spatial gene expression across multiple gastruloids highlights macro-scale organizational consistency, simultaneous with variance in meso-scale patterning.
4. 1. Computational and Systems Biology
   2. Neuroscience

   Opening the black box toward a modular approach to spike sorting

   Samuel Garcia, Chris Halcrow ... Pierre Yger

   Modularized spike sorting pipelines can identify performance bottlenecks, lower contribution barriers, and enable the development of highly accurate algorithms to turn extracellular recordings into spikes.
5. 1. Computational and Systems Biology
   2. Neuroscience

   Real-time closed-loop feedback system for mouse mesoscale cortical signal and movement control

   Pankaj Kumar Gupta, Timothy H Murphy

   The open-source closed-loop system enables mice to learn modulation of cortical activity or movement by providing a platform for testing brain-behavior relationships in motor learning and neurorehabilitation research.
6. 1. Computational and Systems Biology
   2. Cancer Biology

   MicroRNA spatial profiling for assessing drug efficacy in BRCA1-related triple-negative breast tumors

   Omar N Mohd, Lin Wang ... Patrick S Doyle
7. 1. Computational and Systems Biology

   Role of desolvation on biomolecular liquid-liquid phase separation

   Kai Zhang, Zhiyu Peng ... Wei Wang
8. 1. Genetics and Genomics
   2. Computational and Systems Biology

   Imputation of structural variants using a multi-ancestry long-read sequencing panel enables identification of disease associations

   Boris Noyvert, A Mesut Erzurumluoglu ... Zhihao Ding
9. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Linear antibody epitope prediction using AlphaFold2

   Jacob DeRoo, James S Terry ... Brian J Geiss

   AlphaFold2 can be used to accurately determine linear epitopes of antibodies with known heavy and light chain sequences.
10. 1. Cell Biology
    2. Computational and Systems Biology

    Philosophy of Biology: The power of theory in the life sciences

    Jacob L Fine, Finn Creeggan ... Adam MR Groh

    Theory can help address cell and molecular biology’s major challenges, particularly those arising from large omics datasets.