Computational and Systems Biology

Latest articles

1. 1. Microbiology and Infectious Disease
   2. Computational and Systems Biology

   Petabase-scale Papillomavirus Discovery

   Jessica YQ Shen, Anton Korobeynikov ... Artem Babaian
2. 1. Medicine
   2. Computational and Systems Biology

   Calibration and validation strategy for electromechanical cardiac digital twins

   Zhinuo Jenny Wang, Maxx Holmes ... Blanca Rodriguez
3. 1. Computational and Systems Biology

   Benchmarking biochemical networks generated by large language models

   Jeevan Tewari, Benjamin W Dahl ... Jeffrey J Saucerman
4. 1. Computational and Systems Biology

   Metabolic Trans-Omic Analysis Reveals Key Regulatory Disruption of Energy Metabolism in Alzheimer’s Disease

   Tomoharu Katayama, Hikaru Sugimoto ... Shinya Kuroda
5. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   Experimental verification of the error minimization theory using non-standard genetic codes constructed in vitro

   Ryota Miyachi, Norikazu Ichihashi

   The in vitro experiments that used the artificial genetic codes tested here did not provide support for the error minimization theory.
6. 1. Computational and Systems Biology
   2. Neuroscience

   Comparing the outputs of intramural and extramural grants funded by National Institutes of Health

   Xiang Zheng, Qiyao Yang ... B Ian Hutchins

   Funding mechanisms impact the cost effectiveness of the science conducted, as extramural NIH grants to universities excel at producing papers and citations, while intramural NIH hiring more effectively translates to clinical impact.
7. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Celldetective, an AI-enhanced image analysis tool for unraveling dynamic cell interactions

   Rémy Torro, Beatriz Díaz-Bello ... Laurent Limozin

   Celldetective is an open-source software integrating segmentation, tracking, and event detection to perform high-throughput end-to-end study of dynamic cell interactions, without requiring coding skills, demonstrated on microscopy immunological assays.
8. 1. Computational and Systems Biology

   Environmental statistics and sensory experience shape patch foraging strategies in Drosophila larvae

   Akhila Mudunuri, Klára Tučková ... Katrin Vogt
9. 1. Computational and Systems Biology
   2. Neuroscience

   SqueakPose Studio, an end-to-end platform for pose estimation and real-time edge-AI deployment

   David L Haggerty, Caleb Browning Darden, David Lovinger

   Integrated pose estimation, video acquisition, and edge deployment tools make real-time behavioral analysis more accessible to neuroscience laboratories.
10. 1. Cell Biology
    2. Computational and Systems Biology

    Lipid packing contributes to the confinement of caveolae to the plasma membrane

    Elin Larsson, Aleksei Kabedev ... Richard Lundmark

    Membrane insertion of Dyngo-4a results in a dynamin-independent inhibition of caveola dynamics, revealing that outer leaflet lipid packing in the plasma membrane contributes to the confinement of caveolae.