Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology

   OpenSpliceAI: An efficient, modular implementation of SpliceAI enabling easy retraining on non-human species

   Kuan-Hao Chao, Alan Mao ... Mihaela Pertea
2. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Alternative Splicing Across the Tree of Life: A Comparative Study

   Rebeca de la Fuente, Wladimiro Díaz-Villanueva ... Andrés Moya
3. 1. Computational and Systems Biology
   2. Genetics and Genomics

   The lipocone superfamily, a unifying theme in metabolism of lipids, peptidoglycan and exopolysaccharides, inter-organismal conflicts and immunity

   A Maxwell Burroughs, Gianlucca G Nicastro, L Aravind

   A hitherto unrecognized superfamily of enzymes identified here provides unifying insights spanning lipid metabolism, anti-viral and anti-bacterial immunity, and the origin of developmental regulators like Wnt.
4. 1. Ecology
   2. Computational and Systems Biology

   How bats exit a crowded colony when relying on echolocation only – a modeling approach

   Omer Mazar, Yossi Yovel
5. 1. Computational and Systems Biology
   2. Structural Biology and Molecular Biophysics

   Atomistic simulation of voltage activation of a truncated BK channel

   Zhiguang Jia, Jianhan Chen

   Ten-microsecond atomistic simulations directly capture the voltage activation of the Core-MT big potassium channel, revealing novel voltage sensing and sensor-pore coupling mechanisms that have largely eluded the community.
6. 1. Medicine
   2. Computational and Systems Biology

   Identification of type 2 diabetes- and obesity-associated human β-cells using deep transfer learning

   Gitanjali Roy, Rameesha Syed ... Michael A Kalwat
7. 1. Neuroscience
   2. Computational and Systems Biology

   A Stimulus-Computable Model for Audiovisual Perception and Spatial Orienting in Mammals

   Cesare V Parise
8. 1. Computational and Systems Biology

   The Product neutrality function defining genetic interactions emerges from mechanistic models of cell growth

   Lucas Fuentes Valenzuela, Paul Francois, Jan M Skotheim

   Coarse-grained models of cellular growth and high-throughput empirical genetic data support the Product neutrality function in which a double-mutant fitness is the product of single-mutant fitnesses.
9. 1. Neuroscience
   2. Computational and Systems Biology

   Morphogenesis and morphometry of brain folding patterns across species

   Sifan Yin, Chunzi Liu ... L Mahadevan
10. 1. Computational and Systems Biology
    2. Evolutionary Biology

    Viral genome sequence datasets display pervasive evidence of strand-specific substitution biases that are best described using non-reversible nucleotide substitution models

    Rita Sianga-Mete, Penelope Hartnady ... Darren Patrick Martin