Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology

   Pathway activation model for personalized prediction of drug synergy

   Quang Thinh Trac, Yue Huang ... Trung Nghia Vu
2. 1. Computational and Systems Biology

   Perturbation-response analysis of in silico metabolic dynamics revealed hard-coded responsiveness in the cofactors and network sparsity

   Yusuke Himeoka, Chikara Furusawa

   A computational study reveals that the kinetic models of Escherichia coli metabolism show strong responsiveness to perturbations and that it originates from cofactor dynamics and network sparsity.
3. 1. Computational and Systems Biology
   2. Neuroscience

   MorphoCellSorter is an Andrews plot-based sorting approach to rank microglia according to their morphological features

   Sarah Benkeder, Son-Michel Dinh ... Jean-Christophe Comte

   MorphoCellSorter is a versatile, user-friendly tool that automates microglial morphology ranking, enabling standardized, reproducible analysis across diverse models, imaging techniques, and conditions using principal component analysis and Andrews plots.
4. 1. Computational and Systems Biology
   2. Ecology

   Microbes with higher metabolic independence are enriched in human gut microbiomes under stress

   Iva Veseli, Yiqun T Chen ... A Murat Eren

   Higher biosynthetic capacity of gut microbes in individuals diagnosed with noncommunicable diseases or taking antibiotics suggests that diversity loss and 'dysbiosis' result from microbiome restructuring in response to ecosystem disruption.
5. 1. Computational and Systems Biology
   2. Cancer Biology

   Single-Cell Atlas of AML Reveals Age-Related Gene Regulatory Networks in t(8;21) AML

   Jessica Whittle, Stefan Meyer ... Mudassar Iqbal
6. 1. Neuroscience
   2. Computational and Systems Biology

   Gain neuromodulation mediates task-relevant perceptual switches: evidence from pupillometry, fMRI, and RNN Modelling

   Gabriel Wainstein, Christopher J Whyte ... James M Shine
7. 1. Computational and Systems Biology
   2. Neuroscience

   Sensorimotor delays constrain robust locomotion in a 3D kinematic model of fly walking

   Lili Karashchuk, Jing Shuang Li ... Bingni W Brunton

   A model that simulates realistic fly walking uses an anatomically-inspired layered architecture to achieve robust walking, quantifying the tolerance of this circuit to sensorimotor delays.
8. 1. Neuroscience
   2. Computational and Systems Biology

   A Stimulus-Computable Model for Audiovisual Perception and Spatial Orienting in Mammals

   Cesare V Parise
9. 1. Computational and Systems Biology
   2. Cancer Biology

   Drug combination prediction for cancer treatment using disease-specific drug response profiles and single-cell transcriptional signatures

   Daniel Osorio, Parastoo Shahrouzi ... Marieke L Kuijjer
10. 1. Immunology and Inflammation
    2. Computational and Systems Biology

    Tissue resident memory CD4⁺ T cells are sustained by site-specific levels of self-renewal and continuous replacement

    Jodie Chandler, M Elise Bullock ... Andrew J Yates