Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Metrics of high cofluctuation and entropy to describe control of cardiac function in the stellate ganglion

   Nil Z Gurel, Koustubh B Sudarshan ... Olujimi A Ajijola
2. 1. Computational and Systems Biology
   2. Neuroscience

   Self-configuring feedback loops for sensorimotor control

   Sergio Oscar Verduzco-Flores, Erik De Schutter

   Learning to reach in the sensorimotor loop, and the required neural dynamics, can be potentially explained by simple principles.
3. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   T cell receptor convergence is an indicator of antigen-specific T cell response in cancer immunotherapies

   Mingyao Pan, Bo Li

   Amino acid codon degeneracy indicates antigen-specific selection of the T cell receptors and is predictive of cancer immunotherapy outcomes.
4. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Landscape of epithelial–mesenchymal plasticity as an emergent property of coordinated teams in regulatory networks

   Kishore Hari, Varun Ullanat ... Mohit Kumar Jolly

   Investigation of regulatory network topology reveals latent design principles of multistable phenotypic landscape.
5. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Transcriptome-wide association study and eQTL colocalization identify potentially causal genes responsible for human bone mineral density GWAS associations

   Basel Maher Al-Barghouthi, Will T Rosenow ... Charles R Farber

   Systems genetics approaches identify potentially causal bone mineral density genes.
6. 1. Computational and Systems Biology

   A tug of war between filament treadmilling and myosin induced contractility generates actin rings

   Qin Ni, Kaustubh Wagh ... Garegin A Papoian

   Actin networks form clusters under myosin-induced contractility, while high actin filament treadmilling speed can reshape actin networks into ring-like structures with lower mechanical energy.
7. 1. Computational and Systems Biology
   2. Neuroscience

   High-throughput automated methods for classical and operant conditioning of Drosophila larvae

   Elise C Croteau-Chonka, Michael S Clayton ... Kristina T Klein

   A novel high-throughput FPGA-based multi-animal tracking and training system was used to demonstrate trace and operant conditioning in Drosophila larvae.
8. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Evolution and regulation of microbial secondary metabolism

   Guillem Santamaria, Chen Liao ... Joao B Xavier
9. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Measurements of damage and repair of binary health attributes in aging mice and humans reveal that robustness and resilience decrease with age, operate over broad timescales, and are affected differently by interventions

   Spencer Farrell, Alice E Kane ... Andrew David Rutenberg
10. 1. Computational and Systems Biology
    2. Neuroscience

    Mesoscale cortex-wide neural dynamics predict self-initiated actions in mice several seconds prior to movement

    Catalin Mitelut, Yongxu Zhang ... Timothy H Murphy

    Mouse self-initiated behaviors can be identified seconds prior to action and have similar neuro-dynamical structure to neural dynamics underlying human voluntary actions supporting the use of mouse models in self-initiated and volitional action research.