Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Celldetective, an AI-enhanced image analysis tool for unraveling dynamic cell interactions

   Rémy Torro, Beatriz Díaz-Bello ... Laurent Limozin

   Celldetective is an open-source software integrating segmentation, tracking, and event detection to perform high-throughput end-to-end study of dynamic cell interactions, without requiring coding skills, demonstrated on microscopy immunological assays.
2. 1. Computational and Systems Biology

   Environmental statistics and sensory experience shape patch foraging strategies in Drosophila larvae

   Akhila Mudunuri, Klára Tučková ... Katrin Vogt
3. 1. Computational and Systems Biology
   2. Physics of Living Systems

   A coma pattern-based autofocusing method resolves bacterial cold shock response at single-cell level

   Sihong Li, Zhixin Ma ... Shuqiang Huang

   A robust autofocusing method enables continuous single-cell imaging during rapid cooling, revealing sustained bacterial proliferation hidden by growth arrest inferred from optical-density measurements.
4. 1. Computational and Systems Biology
   2. Neuroscience

   SqueakPose Studio, an end-to-end platform for pose estimation and real-time edge-AI deployment

   David L Haggerty, Caleb Browning Darden, David Lovinger

   Integrated pose estimation, video acquisition, and edge deployment tools make real-time behavioral analysis more accessible to neuroscience laboratories.
5. 1. Cell Biology
   2. Computational and Systems Biology

   Lipid packing contributes to the confinement of caveolae to the plasma membrane

   Elin Larsson, Aleksei Kabedev ... Richard Lundmark

   Membrane insertion of Dyngo-4a results in a dynamin-independent inhibition of caveola dynamics, revealing that outer leaflet lipid packing in the plasma membrane contributes to the confinement of caveolae.
6. 1. Computational and Systems Biology

   TopoMetry systematically learns and evaluates the latent geometry of single-cell data

   David Sidarta-Oliveira, Ana I Domingos, Licio A Velloso

   A framework for analyzing single-cell genomics data, in which geometrical properties are harnessed to obtain insights on cellular diversity, including precise clustering, clear visualizations, and intuitive diagnostics.
7. 1. Neuroscience
   2. Computational and Systems Biology

   Real-Time Closed-Loop Feedback System For Mouse Mesoscale Cortical Signal And Movement Control: CLoPy

   Pankaj K Gupta, Timothy H Murphy
8. 1. Computational and Systems Biology

   TSvelo: Comprehensive RNA velocity by modeling the cascade of gene regulation, transcription and splicing

   Jiachen Li, Zhe Wang ... Ye Yuan
9. 1. Immunology and Inflammation
   2. Computational and Systems Biology

   Clonal stochasticity in early NK cell response to mouse cytomegalovirus is generated by mature subsets of varying proliferative ability

   Darren Wethington, Saeed Ahmad ... Jayajit Das
10. 1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Atomistic simulations reveal sub-µs contact dynamics in MUT-16 condensates

    Kumar Gaurav, Lucia Baltz ... Lukas S Stelzl