Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Medicine

   An integrative model of cardiometabolic traits identifies two types of metabolic syndrome

   Amit Frishberg et al.

   A novel type of metabolic syndrome, derived from computational modeling of phenotypic diversity in normal physiological settings, increases the risk of certain complex diseases.
2. 1. Computational and Systems Biology
   2. Neuroscience

   Graphical-model framework for automated annotation of cell identities in dense cellular images

   Shivesh Chaudhary et al.
3. 1. Computational and Systems Biology

   Shape deformation analysis reveals the temporal dynamics of cell-type-specific homeostatic and pathogenic responses to mutant huntingtin

   Lucile Megret et al.

   Cell-type-specific molecular systems mapping reveals that striatal neuron degeneration in Huntington's disease is primarily driven by the loss of homeostatic responses.
4. 1. Cell Biology
   2. Computational and Systems Biology

   Identifying molecular features that are associated with biological function of intrinsically disordered protein regions

   Taraneh Zarin et al.
5. 1. Computational and Systems Biology
   2. Medicine

   Individual variation in Achilles tendon morphology and geometry changes susceptibility to injury

   Nai-Hao Yin et al.

   Studying individual Achilles tendon geometry and interface sliding capacity may allow prediction of injury sites, and targeted training on specific muscle-(sub-)tendon units may boost beneficial outcomes for Achilles tendinopathy.
6. 1. Computational and Systems Biology
   2. Developmental Biology

   Constructing and optimizing 3D atlases from 2D data with application to the developing mouse brain

   David M Young et al.
7. 1. Cancer Biology
   2. Computational and Systems Biology

   shinyDepMap, a tool to identify targetable cancer genes and their functional connections from Cancer Dependency Map data

   Kenichi Shimada et al.
8. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   Global, cell non-autonomous gene regulation drives individual lifespan among isogenic C. elegans

   Holly E Kinser et al.

   Expression of almost half of a library of fluorescent reporters distinguish long- from short-lived individual Caenorhabditis elegans, suggesting that organism-wide differences in gene expression drive future lifespan.
9. 1. Computational and Systems Biology

   Cycles, sources, and sinks: Conceptualizing how phosphate balance modulates carbon flux using yeast metabolic networks

   Ritu Gupta, Sunil Laxman

   A theoretical conceptualization of how phosphates control metabolic information flow and predictably regulate the metabolic state of the cell.
10. 1. Computational and Systems Biology

    Metage2Metabo, microbiota-scale metabolic complementarity for the identification of key species

    Arnaud Belcour et al.

    Computational models and software connect metagenomics to metabolic network reconstruction, assess metabolic complementarity between species, and identify critical species associated to functions of interest.