Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Neuroscience

   Multilayer brain networks can identify the epileptogenic zone and seizure dynamics

   Hossein Shahabi, Dileep R Nair, Richard M Leahy

   Aging and the duration of epilepsy can intensify the high-frequency desynchronization between the epileptogenic zone and the rest of the brain in early to mid-seizure.
2. 1. Computational and Systems Biology
   2. Genetics and Genomics

   The potential of integrating human and mouse discovery platforms to advance our understanding of cardiometabolic diseases

   Aaron W Jurrjens, Marcus M Seldin ... Anna C Calkin

   The benefits of integrating cross-species systems genetics platforms to advance knowledge in the underlying mechanisms that drive cardiometabolic diseases have been investigated.
3. 1. Computational and Systems Biology

   ProteInfer, deep neural networks for protein functional inference

   Theo Sanderson, Maxwell L Bileschi ... Lucy J Colwell

   A machine learning model predicts the properties of proteins from their amino acid sequences and can run in a user's web browser.
4. 1. Computational and Systems Biology

   Longitudinal fundus imaging and its genome-wide association analysis provide evidence for a human retinal aging clock

   Sara Ahadi, Kenneth A Wilson Jr ... Ali Bashir
5. 1. Computational and Systems Biology

   Generative power of a protein language model trained on multiple sequence alignments

   Damiano Sgarbossa, Umberto Lupo, Anne-Florence Bitbol

   An iterative procedure using language models allows the generation of sequences from protein families, which score similarly to natural and experimentally validated sequences, with particular promise for small families.
6. 1. Cancer Biology
   2. Computational and Systems Biology

   Interrogating the precancerous evolution of pathway dysfunction in lung squamous cell carcinoma using XTABLE

   Matthew Roberts, Julia Ogden ... Carlos Lopez-Garcia

   XTABLE is the first easy-to-use bioinformatic solution that has been conceived and designed solely to interrogate the transcriptomes of premalignant stages of lung squamous cell carcinoma (LUSC) and enhance the development of LUSC prevention and detection strategies.
7. 1. Computational and Systems Biology
   2. Neuroscience

   Endotaxis: A neuromorphic algorithm for mapping, goal-learning, navigation, and patrolling

   Tony Zhang, Matthew Rosenberg ... Markus Meister
8. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Short-range interactions between fibrocytes and CD8⁺ T cells in COPD bronchial inflammatory response

   Edmée Eyraud, Elise Maurat ... Isabelle Dupin
9. 1. Computational and Systems Biology
   2. Neuroscience

   Optimization of energy and time predicts dynamic speeds for human walking

   Rebecca Elizabeth Carlisle, Arthur D Kuo

   Humans often walk in relatively brief bouts whose speed and duration vary dynamically and satisfy an optimal trade-off between effort and time.
10. 1. Computational and Systems Biology

    Dynamics of co-substrate pools can constrain and regulate metabolic fluxes

    Robert West, Hadrien Delattre ... Orkun S Soyer

    Mathematical analyses explore the impact of co-substrate cycling on the dynamics of cellular metabolism, and demonstrate that these dynamics can limit cellular fluxes and that co-substrate pool dynamics can be regulated to regulate fluxes.