Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology

   Deep learning linking mechanistic models to single-cell transcriptomics data reveals transcriptional bursting in response to DNA damage

   Zhiwei Huang, Songhao Luo ... Jiajun Zhang
2. 1. Computational and Systems Biology
   2. Neuroscience

   Biologically informed cortical models predict optogenetic perturbations

   Christos Sourmpis, Carl CH Petersen ... Guillaume Bellec

   Multi area RNN models fitted to in-vivo cortical activity predict behavioral changes induced by optogenetic perturbations, if biologically informed connectivity constraints on the optogenetically targeted inhibitory neurons are applied.
3. 1. Computational and Systems Biology

   Targeted computational design of an interleukin-7 superkine with enhanced folding efficiency and immunotherapeutic efficacy

   See-Khai Lim, Wen-Ching Lin ... Kurt Yun Mou

   Targeted computational redesign of an IL-7 superkine with enhanced folding efficiency and receptor affinity demonstrates superior immune-stimulatory and antitumor activity over wild-type IL-7.
4. 1. Computational and Systems Biology
   2. Neuroscience

   A dynamic scale-mixture model of motion in natural scenes

   Jared M Salisbury, Stephanie E Palmer

   A simple statistical model captures the essential features of object motion in a large database of natural scenes, helping to shed light on the challenges posed to sensory and motor systems.
5. 1. Neuroscience
   2. Computational and Systems Biology

   Real-Time Closed-Loop Feedback System For Mouse Mesoscale Cortical Signal And Movement Control: CLoPy

   Pankaj K Gupta, Timothy H Murphy
6. 1. Computational and Systems Biology

   Nonlinear transcriptional responses to gradual modulation of transcription factor dosage

   Júlia Domingo, Mariia Minaeva ... Tuuli Lappalainen

   A new CRISPR-based approach for tuning gene expression up and down allowed identification of how other genes' expression responds to changes of transcription factors.
7. 1. Developmental Biology
   2. Computational and Systems Biology

   A quantitative pipeline for whole-mount deep imaging and analysis of multi-layered organoids across scales

   Alice Gros, Jules Vanaret ... Sham Tlili
8. 1. Ecology
   2. Computational and Systems Biology

   How bats exit a crowded colony when relying on echolocation only - a modeling approach

   Omer Mazar, Yossi Yovel
9. 1. Computational and Systems Biology

   Predicting the effect of CRISPR-Cas9-based epigenome editing

   Sanjit Singh Batra, Alan Cabrera ... Yun S Song

   Machine learning models reveal that histone marks are predictive of gene expression across human cell types and highlight important nuances between natural control and the effects of CRISPR-Cas9-based epigenome editing.
10. 1. Neuroscience
    2. Computational and Systems Biology

    Motor biases reflect a misalignment between visual and proprioceptive reference frames

    Tianhe Wang, Ryan J Morehead ... Jonathan S Tsay