Computational and Systems Biology

Computational and Systems Biology

eLife reviews research involving the use of methods, models and software. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Neuroscience
    2. Computational and Systems Biology

    Opening the black box: a modular approach to spike sorting

    Samuel Garcia, Chris Halcrow ... Pierre Yger
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Computational and Systems Biology

    A real-time, multi-animal model for automatic face detection and identification of freely moving common marmosets based on YOLOv8 algorithms

    Jiayue Yang, James Wang, Justine Cléry
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Out-of-balance Growth Enables Cost-free Synthesis of the Flagellum and Other Proteins in a Single Bacterium

    Mayra Garcia-Alcala, Josiah C Kratz, Philippe Cluzel
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Computational and Systems Biology

    Fully computational design of PAM-relaxed Staphylococcus aureus Cas9 with expanded targeting capability

    Youcai Xiong, Li-Kuang Tsai ... Xiaoqiang Huang
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Computational and Systems Biology
    2. Neuroscience

    Visual information is broadcast among cortical areas in discrete channels

    Yiyi Yu, Jeffery N Stirman ... Spencer LaVere Smith
    Activity fluctuations, or noise correlations, are robust measures of neuronal connectivity and they reveal that neural circuity controls mixing of information at a granular level across millimeter-length scales.
    1. Computational and Systems Biology

    Anatomical basis of sex differences in the electrocardiogram identified by three-dimensional torso-heart imaging reconstruction pipeline

    Hannah J Smith, Blanca Rodriguez ... Abhirup Banerjee
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    DNA O-MAP uncovers the molecular neighborhoods associated with specific genomic loci

    Yuzhen Liu, Christopher D McGann ... Devin K Schweppe
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Computational and Systems Biology
    2. Medicine

    Global molecular landscape of early MASLD progression in human obesity

    Qing Zhao, William De Nardo ... Philipp Kaldis
    GTPases could be drivers of liver fibrosis in MASLD and potential future therapeutic targets.
    1. Neuroscience
    2. Computational and Systems Biology

    High frequency spike inference with particle Gibbs sampling

    Giovanni Diana, B Semihcan Sermet ... David A DiGregorio
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Computational and Systems Biology
    2. Cancer Biology

    Systematic Analysis of Network-driven Adaptive Resistance to CDK4/6 and Estrogen Receptor Inhibition using Meta-Dynamic Network Modelling

    Anthony Hart, Sung-Young Shin, Lan K Nguyen
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
Load more

Highlights

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

    Submit to our latest special issue in systems genetics

    1. Cancer Biology
    2. Computational and Systems Biology

    eLife publishes final papers from the Reproducibility Project: Cancer Biology

    Timothy M Errington, Maya Mathur ... Brian A Nosek
    1. Computational and Systems Biology

    International aspects of bioRxiv preprints

    Richard J Abdill, Elizabeth M Adamowicz, Ran Blekhman

Senior editors

  1. Alan Moses
    University of Toronto, Canada
  2. Aleksandra Walczak
    Ecole Normale Superieure, France
  3. See more editors