Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Neuroscience

   Stable task information from an unstable neural population

   Michael E Rule et al.
2. 1. Computational and Systems Biology
   2. Structural Biology and Molecular Biophysics

   Local frustration determines loop opening during the catalytic cycle of an oxidoreductase

   Lukas S Stelzl et al.

   The cysteine pair oxidation state in nDsbD acts as a ‘switch’ controlling the presence or absence of frustration in the active-site and determining the dynamic behavior of the cap loop.
3. 1. Computational and Systems Biology
   2. Human Biology and Medicine

   SARS-CoV-2 strategically mimics proteolytic activation of human ENaC

   Praveen Anand et al.

   SARS-CoV-2 has evolved to cleverly mimic the FURIN-cleavage site in human ENaC-α, unlike any prior coronavirus strain, shedding new light on the Acute Respiratory Distress Syndrome (ARDS) in COVID-19 patients.
4. 1. Computational and Systems Biology
   2. Human Biology and Medicine

   Unsupervised machine learning reveals risk stratifying glioblastoma tumor cells

   Nalin Leelatian et al.

   A new automated and unsupervised algorithm, Risk Assessment Population IDentification, identifies risk-stratifying cells in single cell datasets with robust statistical and biological validation.
5. 1. Computational and Systems Biology
   2. Human Biology and Medicine

   A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm

   Mike R Garvin et al.
6. 1. Computational and Systems Biology
   2. Neuroscience

   Dopamine role in learning and action inference

   Rafal Bogacz
7. 1. Computational and Systems Biology
   2. Neuroscience

   The head direction circuit of two insect species

   Ioannis Pisokas et al.
8. 1. Computational and Systems Biology
   2. Neuroscience

   Movement initiation and grasp representation in premotor and primary motor cortex mirror neurons

   Steven Jack Jerjian et al.
9. 1. Computational and Systems Biology
   2. Developmental Biology

   The dynamic transmission of positional information in stau^- mutants during Drosophila embryogenesis

   Zhe Yang et al.

   In stau^-mutants, the Hunchback boundary shifts posteriorly by 10% EL but shows comparable variability to that of the wild type in short time windows in nuclear cycle 14.
10. 1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Coverage-dependent bias creates the appearance of binary splicing in single cells

    Carlos F Buen Abad Najar et al.