Computational and Systems Biology

Computational and Systems Biology

eLife reviews research involving the use of methods, models and software. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Atomistic simulations reveal sub-µs contact dynamics in MUT-16 condensates

    Kumar Gaurav, Lucia Baltz ... Lukas S Stelzl
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Neuroscience
    2. Computational and Systems Biology

    SqueakPose Studio: An end-to-end platform for pose estimation and real-time edge-AI deployment

    David L Haggerty, Caleb B Darden, David M Lovinger
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Incomplete
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Methylation Clocks Do Not Predict Age or Alzheimer’s Disease Risk Across Genetically Admixed Individuals

    Sebastián Cruz-González, Ogechukwu Okpala ... John A Capra
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience
    2. Computational and Systems Biology

    Comparing the outputs of intramural and extramural grants funded by National Institutes of Health

    Xiang Zheng, Qiyao Yang ... B Ian Hutchins
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Developmental Biology
    2. Computational and Systems Biology

    Single-cell spatial mapping reveals reproducible cell type organization and spatially-dependent gene expression in gastruloids

    Catherine G Triandafillou, Pranav Sompalle ... Arjun Raj
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Experimental verification of the error minimization theory using non-standard genetic codes constructed in vitro

    Ryota Miyachi, Norikazu Ichihashi
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Computational and Systems Biology

    Generative modeling for RNA splicing prediction and design

    Di Wu, Natalie Maus ... Yoseph Barash
    TrASPr+BOS enables accurate prediction and design of tissue-specific RNA splicing, even for tissues not trained on, uncovering unseen regulatory elements and guiding sequence edits that reshape splicing outcomes.
    1. Computational and Systems Biology

    Role of desolvation on biomolecular liquid-liquid phase separation

    Kai Zhang, Zhiyu Peng ... Wei Wang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Evolutionary remodeling of non-canonical ORF translation in mammals

    Yue Chang, Tianyu Lei ... Hong Zhang
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Computational and Systems Biology

    High-frequency spike inference with particle Gibbs sampling

    Giovanni Diana, B Semihcan Sermet ... David A DiGregorio
    A Bayesian particle Gibbs framework enables unbiased spike time inference with millisecond resolution and jointly estimates uncertainties in both spike timing and model parameters from fast calcium imaging.
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Highlights

    1. Computational and Systems Biology
    2. Genetics and Genomics

    Wnt Signaling: Exploring the origins of a signaling pathway

    Balaji Santhanam
    1. Computational and Systems Biology

    Methylation: Modifying gene expression through passive forces

    Sarah Hallstein, Julian König
    1. Computational and Systems Biology

    Cellular Respiration: Mapping mitochondrial aging

    Alessandro Bitto

Senior editors

  1. Alan Moses
    University of Toronto, Canada
  2. Aleksandra Walczak
    Ecole Normale Superieure, France
  3. See more editors