Computational and Systems Biology

Latest articles

1. 1. Developmental Biology
   2. Computational and Systems Biology

   Single-cell spatial mapping reveals reproducible cell type organization and spatially-dependent gene expression in gastruloids

   Catherine G Triandafillou, Pranav Sompalle ... Arjun Raj
2. 1. Computational and Systems Biology

   TSvelo: Comprehensive RNA velocity by modeling the cascade of gene regulation, transcription and splicing

   Jiachen Li, Zhe Wang ... Ye Yuan
3. 1. Computational and Systems Biology
   2. Neuroscience

   Active dendrites enable robust spiking computations despite timing jitter

   Thomas SJ Burger, Michael E Rule, Timothy O'Leary

   The brain computes rapidly and reliably using brief electrical impulses and likely exploits internal memory in nerve cells to achieve this more efficiently than existing computing hardware and neural networks.
4. 1. Computational and Systems Biology

   Permute-match tests detect significant correlations between time series despite nonstationarity and limited replicates

   Alex E Yuan, Wenying Shou
5. 1. Computational and Systems Biology

   Large-scale synthetic data enable digital twins of human excitable cells

   Pei-Chi Yang, Mao-Tsuen Jeng ... Colleen E Clancy

   Large-scale synthetic datasets enable construction of digital twins of individual human excitable cells from a single voltage-clamp recording.
6. 1. Computational and Systems Biology

   Functional muscle networks as biomarkers of post-stroke motor impairment and therapeutic responsiveness

   David O'Reilly, Giorgia Pregnolato ... Giacomo Severini

   The proposed muscle network analysis framework identifies a redundancy-to-synergy shift as a marker of stroke recovery, yielding new biomarkers that could objectively quantify functional impairment and rehabilitation efficacy.
7. 1. Computational and Systems Biology
   2. Developmental Biology

   Quantitative computerized analysis demonstrates strongly compartmentalized tissue deformation patterns underlying mammalian heart tube formation

   Morena Raiola, Miquel Sendra Sendra ... Miguel Torres

   A computational pipeline leverages mammalian heart development videos to extract tissue deformation patterns and generate a virtual fate map tool that provides new insights into cardiac morphogenesis.
8. 1. Microbiology and Infectious Disease
   2. Computational and Systems Biology

   Petabase-scale Papillomavirus Discovery

   Jessica YQ Shen, Anton Korobeynikov ... Artem Babaian
9. 1. Medicine
   2. Computational and Systems Biology

   Calibration and validation strategy for electromechanical cardiac digital twins

   Zhinuo Jenny Wang, Maxx Holmes ... Blanca Rodriguez
10. 1. Computational and Systems Biology

    Benchmarking biochemical networks generated by large language models

    Jeevan Tewari, Benjamin W Dahl ... Jeffrey J Saucerman