Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Author-sourced capture of pathway knowledge in computable form using Biofactoid

   Jeffrey V Wong et al.
2. 1. Computational and Systems Biology
   2. Medicine

   Topological network analysis of patient similarity for precision management of acute blood pressure in spinal cord injury

   Abel Torres-Espín et al.

   The application of topological network analysis on multicenter high-frequency intra-operative physiology data discovers a precise range of blood pressure during surgery predicting poor recovery in spinal cord injury patients.
3. 1. Computational and Systems Biology
   2. Structural Biology and Molecular Biophysics

   Markov state models of proton- and pore-dependent activation in a pentameric ligand-gated ion channel

   Cathrine Bergh et al.

   Computational models of gating processes in an ion channel show how stability shifts upon ligand-binding and mutations are reproduced, which highlights mechanistic details and proposes a new role for symmetry in gating.
4. 1. Computational and Systems Biology
   2. Neuroscience

   Daily electrical activity in the master circadian clock of a diurnal mammal

   Beatriz Bano-Otalora et al.

   Circadian control of neuronal excitability in the master circadian clock of a diurnal mammal as revealed by whole-cell recording and mathematical modeling.
5. 1. Computational and Systems Biology
   2. Neuroscience

   Circadian Rhythm: How neurons adjust to diurnality

   Gabriele Andreatta, Charles N Allen

   Being active during the day requires a slow-closing ion channel that dampens the activity of neurons in a specific area of the brain.
6. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   TCR meta-clonotypes for biomarker discovery with tcrdist3 enabled identification of public, HLA-restricted clusters of SARS-CoV-2 TCRs

   Koshlan Mayer-Blackwell et al.

   Distance-based TCR analysis enables grouping of biochemically similar clonotypes into meta-clonotypes that have increased publicity, and therefore statistical power, for population-level detection of antigen-specific T cells in infection and vaccination.
7. 1. Computational and Systems Biology
   2. Genetics and Genomics

   A computational screen for alternative genetic codes in over 250,000 genomes

   Yekaterina Shulgina, Sean R Eddy

   Five previously unknown alternative genetic codes are found in a screen of bacterial and archaeal genomes by a new computational method called Codetta, lending new insights into the process of their evolution.
8. 1. Computational and Systems Biology
   2. Developmental Biology

   Supracellular organization confers directionality and mechanical potency to migrating pairs of cardiopharyngeal progenitor cells

   Yelena Y Bernadskaya et al.
9. 1. Cancer Biology
   2. Computational and Systems Biology

   Quantitative analysis of tumour spheroid structure

   Alexander P Browning et al.
10. 1. Computational and Systems Biology
    2. Medicine

    Data-driven methodology for discovery and response to pulmonary symptomology in hypertension through statistical learning and data mining: Application to COVID-19 related pharmacovigilance

    Xuan Xu et al.