Computational and Systems Biology

Latest articles

1. 1. Cancer Biology
   2. Computational and Systems Biology

   A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity

   Adam C Palmer et al.

   Drugs in a curative chemotherapy regimen are independently effective and resisted by different mechanisms, so cancer cells have little chance of surviving all drugs, and this benefit occurs without synergistic interactions.
2. 1. Computational and Systems Biology

   Meta-Research: Releasing a preprint is associated with more attention and citations for the peer-reviewed article

   Darwin Y Fu, Jacob J Hughey
3. 1. Computational and Systems Biology
   2. Plant Biology

   Evolution of C4 photosynthesis predicted by constraint-based modelling

   Mary-Ann Blätke, Andrea Bräutigam
4. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   Initiation of chromosome replication controls both division and replication cycles in E. coli through a double-adder mechanism

   Guillaume Witz et al.

   Single-cell measurements combined with a new statistical framework for discriminating between models of cell cycle regulation show that chromosome initiation controls the E. coli cell cycle via two adder mechanisms.
5. 1. Computational and Systems Biology
   2. Neuroscience

   Differences in topological progression profile among neurodegenerative diseases from imaging data

   Sara Garbarino et al.
6. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Systematic genetic analysis of the MHC region reveals mechanistic underpinnings of HLA type associations with disease

   Matteo D'Antonio et al.
7. 1. Cancer Biology
   2. Computational and Systems Biology

   Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome

   Amanda B Abildgaard et al.

   Biophysical modeling, performed in silico, can predict the abundance, metabolic stability, and function of MLH1 inside living cells.
8. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Adaptation to mutational inactivation of an essential gene converges to an accessible suboptimal fitness peak

   João V Rodrigues, Eugene I Shakhnovich

   When an essential metabolic gene in E. coli is mutationally inactivated, subsequent evolution rarely reverts the mutation to wild type but rather follows unexpected paths that rewire metabolic fluxes.
9. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   Bacterial survival in microscopic surface wetness

   Maor Grinberg et al.

   A new intricate reciprocity between microbiology and physics results in collective protection from desiccation through differential formation of stable microdroplets around bacterial aggregates on surfaces drying under moderate humidity.
10. 1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Bacterial Survival: Life on a leaf

    Robin Tecon

    Microscopic water films allow bacteria to survive the seemingly dry surface of plant leaves.