Computational and Systems Biology

Latest articles

1. 1. Cell Biology
   2. Computational and Systems Biology

   A regulatory microRNA network controls endothelial cell phenotypic switch during sprouting angiogenesis

   Stefania Rosano et al.

   Coordinated microRNAs activity induced by VEGF represses cell proliferation and favors cell migration at the onset of sprouting angiogenesis in endothelial cells.
2. 1. Computational and Systems Biology

   Hidden long-range memories of growth and cycle speed correlate cell cycles in lineage trees

   Erika E Kuchen et al.
3. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Receptor-based mechanism of relative sensing and cell memory in mammalian signaling networks

   Eugenia Lyashenko et al.
4. 1. Cell Biology
   2. Computational and Systems Biology

   Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block

   Jakub Tomek et al.

   A computer model of human cardiomyocyte was produced and validated on independent datasets, overcoming shortcomings of its predecessors, also yielding broadly relevant insights and results on major ionic currents.
5. 1. Computational and Systems Biology
   2. Genetics and Genomics

   CNApp, a tool for the quantification of copy number alterations and integrative analysis revealing clinical implications

   Sebastià Franch-Expósito et al.
6. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions

   Luis V Nobre et al.

   The human cytomegalovirus (HCMV) interactome systematically characterises high-confidence viral-viral and viral-host protein interactions in HCMV-infected cells, facilitating multiple novel insights into HCMV and herpesviral function.
7. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m⁶A modification

   Matthew T Parker et al.

   Sequencing mRNA directly with nanopores can reveal the authentic combinations of multiple mRNA processing events in full-length mRNA molecules in addition to identifying base modifications.
8. 1. Computational and Systems Biology

   The bottom-up and top-down processing of faces in the human occipitotemporal cortex

   Xiaoxu Fan et al.
9. 1. Computational and Systems Biology
   2. Structural Biology and Molecular Biophysics

   Common activation mechanism of class A GPCRs

   Qingtong Zhou et al.

   Contrary to previous findings, class A GPCRs share a common activation pathway that directly links ligand binding to G-protein activation, as revealed by novel quantitative analysis.
10. 1. Computational and Systems Biology
    2. Neuroscience

    From behavior to circuit modeling of light-seeking navigation in zebrafish larvae

    Sophia Karpenko et al.