Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology

   Functional muscle networks as biomarkers of post-stroke motor impairment and therapeutic responsiveness

   David O'Reilly, Giorgia Pregnolato ... Giacomo Severini

   The proposed muscle network analysis framework identifies a redundancy-to-synergy shift as a marker of stroke recovery, yielding new biomarkers that could objectively quantify functional impairment and rehabilitation efficacy.
2. 1. Computational and Systems Biology

   Large-scale synthetic data enable digital twins of human excitable cells

   Pei-Chi Yang, Mao-Tsuen Jeng ... Colleen E Clancy

   Large-scale synthetic datasets enable construction of digital twins of individual human excitable cells from a single voltage-clamp recording.
3. 1. Computational and Systems Biology
   2. Developmental Biology

   Quantitative computerized analysis demonstrates strongly compartmentalized tissue deformation patterns underlying mammalian heart tube formation

   Morena Raiola, Miquel Sendra Sendra ... Miguel Torres

   A computational pipeline leverages mammalian heart development videos to extract tissue deformation patterns and generate a virtual fate map tool that provides new insights into cardiac morphogenesis.
4. 1. Microbiology and Infectious Disease
   2. Computational and Systems Biology

   Petabase-scale Papillomavirus Discovery

   Jessica YQ Shen, Anton Korobeynikov ... Artem Babaian
5. 1. Medicine
   2. Computational and Systems Biology

   Calibration and validation strategy for electromechanical cardiac digital twins

   Zhinuo Jenny Wang, Maxx Holmes ... Blanca Rodriguez
6. 1. Computational and Systems Biology

   Benchmarking biochemical networks generated by large language models

   Jeevan Tewari, Benjamin W Dahl ... Jeffrey J Saucerman
7. 1. Computational and Systems Biology

   Metabolic Trans-Omic Analysis Reveals Key Regulatory Disruption of Energy Metabolism in Alzheimer’s Disease

   Tomoharu Katayama, Hikaru Sugimoto ... Shinya Kuroda
8. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   Experimental verification of the error minimization theory using non-standard genetic codes constructed in vitro

   Ryota Miyachi, Norikazu Ichihashi

   The in vitro experiments that used the artificial genetic codes tested here did not provide support for the error minimization theory.
9. 1. Computational and Systems Biology
   2. Neuroscience

   Comparing the outputs of intramural and extramural grants funded by National Institutes of Health

   Xiang Zheng, Qiyao Yang ... B Ian Hutchins

   Funding mechanisms impact the cost effectiveness of the science conducted, as extramural NIH grants to universities excel at producing papers and citations, while intramural NIH hiring more effectively translates to clinical impact.
10. 1. Computational and Systems Biology
    2. Immunology and Inflammation

    Celldetective, an AI-enhanced image analysis tool for unraveling dynamic cell interactions

    Rémy Torro, Beatriz Díaz-Bello ... Laurent Limozin

    Celldetective is an open-source software integrating segmentation, tracking, and event detection to perform high-throughput end-to-end study of dynamic cell interactions, without requiring coding skills, demonstrated on microscopy immunological assays.