Computational and Systems Biology

Latest articles

1. 1. Neuroscience
   2. Computational and Systems Biology

   Assemblies, synapse clustering, and network topology interact with plasticity to explain structure-function relationships of the cortical connectome

   András Ecker, Daniela Egas Santander ... Michael W Reimann

   A new framework for exploring the mechanisms underlying learning in cortical microcircuits is established.
2. 1. Computational and Systems Biology

   A neuromorphic model of active vision shows how spatiotemporal encoding in lobula neurons can aid pattern recognition in bees

   HaDi MaBouDi, Mark Roper ... James AR Marshall

   Active vision dynamically refines spatiotemporal neural representations, optimising visual processing through scanning behaviour and non-associative learning, providing insights into efficient sensory encoding in dynamic environments.
3. 1. Computational and Systems Biology

   Methylation: Modifying gene expression through passive forces

   Sarah Hallstein, Julian König

   The mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress.
4. 1. Computational and Systems Biology

   Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism

   David Dierks, Ran Shachar ... Schraga Schwartz

   A quantitative model explains intra- and intercellular changes in m6A gene methylation as passive consequences of mRNA metabolism.
5. 1. Neuroscience
   2. Computational and Systems Biology

   Individuality transfer: Predicting human decision-making across tasks

   Hiroshi Higashi
6. 1. Computational and Systems Biology
   2. Structural Biology and Molecular Biophysics

   Structural characterization and dynamics of AdhE ultrastructures from Clostridium thermocellum show a containment strategy for toxic intermediates

   Samantha J Ziegler, Brandon C Knott ... Yannick J Bomble

   Understanding the dynamics of AdhE enzymes is essential to be able to control the metabolic and energy fluxes in microorganisms used to produce biofuels and biochemicals.
7. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Tissue-resident memory CD4⁺ T cells are sustained by site-specific levels of self-renewal and continuous replacement

   Jodie Chandler, M Elise Bullock ... Andrew J Yates

   Memory CD4 T cells within tissues are highly dynamic, and their continuous replacement may erode immunity to previous infections.
8. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Designing biochemical circuits with tree search

   Pranav S Bhamidipati, Matthew Thomson
9. 1. Structural Biology and Molecular Biophysics
   2. Computational and Systems Biology

   Atomistic Simulation of Voltage Activation of a Truncated BK Channel

   Zhiguang Jia, Jianhan Chen
10. 1. Computational and Systems Biology
    2. Neuroscience

    Evidence from pupillometry, fMRI, and RNN modelling shows that gain neuromodulation mediates task-relevant perceptual switches

    Gabriel Wainstein, Christopher J Whyte ... James M Shine

    Phasic neuromodulatory bursts actively drive adaptive perceptual updating by triggering large-scale brain network reconfigurations, as demonstrated through integrated pupillometry, fMRI, and computational modelling.