Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Rapid, reference-free human genotype imputation with denoising autoencoders

   Raquel Dias, Doug Evans ... Ali Torkamani
2. 1. Cancer Biology
   2. Computational and Systems Biology

   Proteogenomic analysis of cancer aneuploidy and normal tissues reveals divergent modes of gene regulation across cellular pathways

   Pan Cheng, Xin Zhao ... Teresa Davoli

   RNA-level regulation of gene expression is negatively associated with protein-level regulation across cellular pathways in normal tissues and cancer.
3. 1. Computational and Systems Biology
   2. Neuroscience

   Allosteric stabilization of calcium and phosphoinositide dual binding engages several synaptotagmins in fast exocytosis

   Janus RL Kobbersmed, Manon MM Berns ... Alexander M Walter

   A mathematical model of neurotransmitter release predicts that a mutual stabilization of calcium and membrane phospholipids binding to synaptotagmin proteins allows several synaptotagmins to work together for fast synaptic transmission.
4. 1. Computational and Systems Biology

   Empirical single-cell tracking and cell-fate simulation reveal dual roles of p53 in tumor suppression

   Ann Rancourt, Sachiko Sato, Masahiko S Satoh
5. 1. Computational and Systems Biology

   Network design principle for robust oscillatory behaviors with respect to biological noise

   Lingxia Qiao, Zhi-Bo Zhang ... Lei Zhang

   Searching all two- and three-node gene regulatory network topologies identifies the repressilator with positive autoregulation as the motif capable of accurate oscillation and reveals the long period and high amplitude as two distinct mechanisms for buffering different noise.
6. 1. Computational and Systems Biology
   2. Neuroscience

   Contribution of behavioural variability to representational drift

   Sadra Sadeh, Claudia Clopath

   By analysing large-scale datasets from the Allen Brain Observatory, we found that changes in the behavioural state of the animal can significantly contribute to the changes in representational similarity over time.
7. 1. Computational and Systems Biology
   2. Neuroscience

   Reverse engineering of metacognition

   Matthias Guggenmos

   A model framework and toolbox to quantify metacognitive biases and sources of metacognitive noise in animal and human confidence data.
8. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Eco-evolutionary dynamics of clonal multicellular life cycles

   Vanessa Ress, Arne Traulsen, Yuriy Pichugin

   The evolution of clonal multicellular life cycles, whose growth is constrained by competition, may lead to coexistence or multistability between several life cycles while evolutionarily stable strategies can be inferred from the analysis of a model with unconstrained growth.
9. 1. Cell Biology
   2. Computational and Systems Biology

   A unified view of low complexity regions (LCRs) across species

   Byron Lee, Nima Jaberi-Lashkari, Eliezer Calo

   Disparate functions of low complexity regions of proteins can be understood through a global view of their sequences, features, and relationships across different organisms and biological contexts.
10. 1. Computational and Systems Biology
    2. Neuroscience

    Automatically tracking feeding behavior in populations of foraging C. elegans

    Elsa Bonnard, Jun Liu ... Monika Scholz

    A new tool enables measuring feeding and locomotion simultaneously which will enable insights into environmental, developmental, neuronal, and genetic factors underlying behavioral regulation.