Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophy

   Karthickeyan Chella Krishnan, Elie-Julien El Hachem ... Aldons J Lusis

   The discovery of three distinct and independent trans-regulating genomic loci influencing heart mass using a well-characterized mouse reference population provides evidence in support of the hypothesis that genetic diversity in the mitochondrial proteome plays a critical role in heart pathophysiology.
2. 1. Computational and Systems Biology

   Shared enhancer gene regulatory networks between wound and oncogenic programs

   Swann Floc'hlay, Ramya Balaji ... Stein Aerts

   Single-cell multiomics reveals the gene regulatory networks and enhancer logic underlying two distinct wound response cell states in the Drosophila wing imaginal disc and finds similarities with cell states observed in the Ras-scrib tumor model.
3. 1. Cancer Biology
   2. Computational and Systems Biology

   Comprehensive characterization of tumor microenvironment in colorectal cancer via molecular analysis

   Xiangkun Wu, Hong Yan ... Li Liang

   Integrated molecular analysis demonstrated that colorectal cancer can be classified into four molecular subtypes (proliferative, immunomodulatory, immunosuppressed, and immune-excluded subtypes), providing valuable insight into the intricate relationship between tumor microenvironment heterogeneity and various clinical phenotypes.
4. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases

   Aarya Venkat, Grace Watterson ... Natarajan Kannan
5. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Catecholaminergic neuromodulation and selective attention jointly shape perceptual decision making

   S.A. Nuiten, J.W. De Gee ... S. van Gaal
6. 1. Computational and Systems Biology
   2. Neuroscience

   Flexible control of representational dynamics in a disinhibition-based model of decision making

   Bo Shen, Kenway Louie, Paul W Glimcher
7. 1. Computational and Systems Biology
   2. Neuroscience

   Dissecting muscle synergies in the task space

   David Ó’ Reilly, Ioannis Delis
8. 1. Cancer Biology
   2. Computational and Systems Biology

   GENIUS: GEnome traNsformatIon and spatial representation of mUltiomicS data

   Mateo Sokač, Lars Dyrskjøt ... Nicolai J Birkbak
9. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   voyAGEr: free web interface for the analysis of age-related gene expression alterations in human tissues

   Arthur L. Schneider, Nuno Saraiva-Agostinho, Nuno L. Barbosa-Morais
10. 1. Computational and Systems Biology
    2. Genetics and Genomics

    Broad functional profiling of fission yeast proteins using phenomics and machine learning

    María Rodríguez-López, Nicola Bordin ... Jürg Bähler