Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Neuroscience

   Computational modelling identifies key determinants of subregion-specific dopamine dynamics in the striatum

   Aske Ejdrup, Jakob Kisbye Dreyer ... Ulrik Gether

   A computational model of the striatal dopamine system predicts transporter expression and organisation as key determinants of regional striatal dopamine dynamics and distinct signal decoding by D1 and D2 receptors.
2. 1. Computational and Systems Biology

   Benchmarking of signaling networks generated by large language models

   Jeevan Tewari, Benjamin W Dahl, Jeffrey J Saucerman
3. 1. Computational and Systems Biology
   2. Developmental Biology

   Anti-resonance in developmental signaling regulates cell fate decisions

   Samuel J Rosen, Olivier Witteveen ... Maxwell Z Wilson

   Human cells decode dynamics Wnt signals using an anti-resonant filter that suppresses intermediate-frequency inputs and is capable of redirecting developmental fate outcomes, including germ-layer specification.
4. 1. Computational and Systems Biology
   2. Neuroscience

   Predicting human decision-making across task conditions via individuality transfer

   Hiroshi Higashi

   Encoding individual behavioral traits into a low-dimensional latent representation enables the accurate prediction of decision-making patterns across distinct task conditions.
5. 1. Computational and Systems Biology

   Deep learning linking mechanistic models to single-cell transcriptomics data reveals transcriptional bursting in response to DNA damage

   Zhiwei Huang, Songhao Luo ... Jiajun Zhang
6. 1. Computational and Systems Biology

   Targeted computational design of an interleukin-7 superkine with enhanced folding efficiency and immunotherapeutic efficacy

   See-Khai Lim, Wen-Ching Lin ... Kurt Yun Mou

   Targeted computational redesign of an IL-7 superkine with enhanced folding efficiency and receptor affinity demonstrates superior immune-stimulatory and antitumor activity over wild-type IL-7.
7. 1. Computational and Systems Biology
   2. Neuroscience

   Biologically informed cortical models predict optogenetic perturbations

   Christos Sourmpis, Carl CH Petersen ... Guillaume Bellec

   Multi area RNN models fitted to in-vivo cortical activity predict behavioral changes induced by optogenetic perturbations, if biologically informed connectivity constraints on the optogenetically targeted inhibitory neurons are applied.
8. 1. Computational and Systems Biology
   2. Neuroscience

   A dynamic scale-mixture model of motion in natural scenes

   Jared M Salisbury, Stephanie E Palmer

   A simple statistical model captures the essential features of object motion in a large database of natural scenes, helping to shed light on the challenges posed to sensory and motor systems.
9. 1. Neuroscience
   2. Computational and Systems Biology

   Real-Time Closed-Loop Feedback System For Mouse Mesoscale Cortical Signal And Movement Control: CLoPy

   Pankaj K Gupta, Timothy H Murphy
10. 1. Computational and Systems Biology

    Nonlinear transcriptional responses to gradual modulation of transcription factor dosage

    Júlia Domingo, Mariia Minaeva ... Tuuli Lappalainen

    A new CRISPR-based approach for tuning gene expression up and down allowed identification of how other genes' expression responds to changes of transcription factors.