Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Quantifying microbial fitness in high-throughput experiments

   Justus Wilhelm Fink, Michael Manhart
2. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Designing biochemical circuits with tree search

   Pranav S Bhamidipati, Matthew Thomson
3. 1. Neuroscience
   2. Computational and Systems Biology

   Individual differences drive social hierarchies in male mouse societies

   Jonathan R Reinwald, Sarah Ghanayem ... Wolfgang Kelsch
4. 1. Computational and Systems Biology
   2. Cancer Biology

   dbGIST: An LLM-Assisted Multi-Omics Resource for Target Exploration and Cross-Dataset Validation in Gastrointestinal Stromal Tumors

   Zhao Sun, Qian Zhao ... Yang Fu
5. 1. Computational and Systems Biology
   2. Stem Cells and Regenerative Medicine

   Combinatorial transcription factor interactions drive modular gene regulatory networks

   Jialei Duan, Boxun Li ... Gary C Hon
6. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Out-of-balance Growth Enables Cost-free Synthesis of the Flagellum and Other Proteins in a Single Bacterium

   Mayra Garcia-Alcala, Josiah C Kratz, Philippe Cluzel
7. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Methylation clocks fail to generalize across genetically admixed individuals

   Sebastián Cruz-Gonzalez, Ogechukwu Okpala ... John A Capra

   DNA-methylation-based predictors of biological age often fail to generalize across human populations, limiting their utility as biomarkers of aging and disease.
8. 1. Neuroscience
   2. Computational and Systems Biology

   Structured stabilization in recurrent neural circuits through inhibitory synaptic plasticity

   Dylan Festa, Claudia Cusseddu, Julijana Gjorgjieva
9. 1. Computational and Systems Biology

   Benchmarking biochemical networks generated by large language models

   Jeevan Tewari, Benjamin W Dahl ... Jeffrey J Saucerman

   Current general-purpose large language models generate signaling and metabolic networks with only modest accuracy relative to manually curated network models.
10. 1. Computational and Systems Biology
    2. Neuroscience

    Dichotomy between extracellular signatures of active dendritic chemical synapses and gap junctions

    Richa Sirmaur, Rishikesh Narayanan

    Fundamental distinctions in the extracellular signatures of active-dendritic chemical and electrical synapses necessitate a revision of conventional interpretations of local field potentials centered on chemical synapses.