Computational and Systems Biology

eLife publishes research involving the use of methods, models and software. Decisions are made by journal editors who are active researchers in computational and systems biology.

Latest articles

    1. Cancer Biology
    2. Computational and Systems Biology

    Defining the biological basis of radiomic phenotypes in lung cancer

    Patrick Grossmann et al.
    1. Biophysics and Structural Biology
    2. Computational and Systems Biology

    Modeling Hsp70/Hsp40 interaction by multi-scale molecular simulations and coevolutionary sequence analysis

    Duccio Malinverni et al.
    Integration of complementary computational approaches reveals an evolutionarily conserved interaction interface between molecular chaperones Hsp70 and Hsp40, rationalizing previous observations.
    Research Article Updated
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    1. Computational and Systems Biology
    2. Neuroscience

    Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition

    Veronica Musante et al.
    A complex interplay between MAST3 and PKA protein kinases and the regulatory protein ARPP-16 allows cAMP to control the activity of protein phosphatase 2A.
    Research Article Updated
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    1. Computational and Systems Biology
    2. Plant Biology

    Topological analysis of multicellular complexity in the plant hypocotyl

    Matthew DB Jackson et al.
    The use of network science to quantify the properties of global cellular organization in the plant hypocotyl identifies higher-order properties and plasticity in epidermal cell patterning.
    Research Article
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    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Microfluidic-based mini-metagenomics enables discovery of novel microbial lineages from complex environmental samples

    Feiqiao Brian Yu et al.
    Microfluidic-based mini-metagenomics enables the investigation of environmental microbial communities in high-throughput and with single-cell resolution, facilitating genome binning and quantification of function, abundance, and genome variation.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf