Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Developmental Biology and Stem Cells

   A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis

   Ajay Mishra et al.
2. 1. Computational and Systems Biology

   Systematic integration of biomedical knowledge prioritizes drugs for repurposing

   Daniel Scott Himmelstein et al.

   Project Rephetio combines data integration and systematic analysis to enable drug repurposing predictions on an unprecedented scale.
3. 1. Computational and Systems Biology

   CDK9-dependent RNA polymerase II pausing controls transcription initiation

   Saskia Gressel et al.
4. 1. Computational and Systems Biology
   2. Neuroscience

   Regulation of sleep homeostasis by sexual arousal

   Esteban J Beckwith et al.

   Sexual arousal, exposure to aphrodisiac pheromones, or mere activation of peripheral pheromone-sensing neurons can modulate sleep homeostasis and are able to counteract the effects of sleep deprivation in Drosophila.
5. 1. Computational and Systems Biology
   2. Neuroscience

   Sleep: To rebound or not to rebound

   Bethany A Stahl, Alex C Keene

   Sexual arousal in flies counteracts the effects of sleep deprivation.
6. 1. Biophysics and Structural Biology
   2. Computational and Systems Biology

   Lipids and ions traverse the membrane by the same physical pathway in the nhTMEM16 scramblase

   Tao Jiang et al.

   A concerted approach employing equilibrium and biased molecular simulations, electrophysiology, mutagenesis, and functional assays reveals, in atomic details, the mechanism and pathway for transport of phospholipids and ions by a lipid scramblase.
7. 1. Computational and Systems Biology
   2. Plant Biology

   Rapid transporter regulation prevents substrate flow traffic jams in boron transport

   Naoyuki Sotta et al.

   To avoid internal traffic jams of nutrients that they absorb, plants need to swiftly regulate the transporters that take up those nutrients.
8. 1. Computational and Systems Biology
   2. Developmental Biology and Stem Cells

   A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning

   Qixuan Wang et al.

   Regional differences in activator and inhibitor signals alter hair cycle pace across mouse skin and produce unique fur renewal 'landscapes', with fastest renewal on the ventrum and slowest renewal on the ear pinnae.
9. 1. Computational and Systems Biology
   2. Genomics and Evolutionary Biology

   MicroCT-based phenomics in the zebrafish skeleton reveals virtues of deep phenotyping in a distributed organ system

   Matthew Hur et al.

   Deep skeletal phenotyping in adult zebrafish reveals enhanced sensitivity of phenomic patterns in discriminating mutant populations.
10. 1. Computational and Systems Biology
    2. Neuroscience

    Fundamental bound on the persistence and capacity of short-term memory stored as graded persistent activity

    Onur Ozan Koyluoglu et al.

    A fundamental lower-bound on memory recall precision, which declines with storage duration and number of stored items, is derived, and human performance is shown to be well-fit by this theoretical bound.