Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology

   A mathematical model that predicts human biological age from physiological traits identifies environmental and genetic factors that influence aging

   Sergiy Libert, Alex Chekholko, Cynthia Kenyon

   A model was developed to predict human biological age from physiological traits, enabling the prediction of future health and mortality and the identification of genetic loci that influence aging.
2. 1. Neuroscience
   2. Computational and Systems Biology

   Neural dynamics of reversal learning in the prefrontal cortex and recurrent neural networks

   Christopher M Kim, Carson C Chow, Bruno B Averbeck
3. 1. Genetics and Genomics
   2. Computational and Systems Biology

   Systematic analysis of transcription factor combinatorial binding uncovers TEAD1 as an antagonist of tissue-specific transcription factors in human organogenesis

   Araceli Garcia-Mora, Joshua Mallen ... Nicoletta Bobola
4. 1. Computational and Systems Biology
   2. Cancer Biology

   BEHAV3D Tumor Profiler to map heterogeneous cancer cell behavior in the tumor microenvironment

   Emilio Rios-Jimenez, Anoek Zomer ... Maria Alieva
5. 1. Medicine
   2. Computational and Systems Biology

   Calibration and validation strategy for electromechanical cardiac digital twins

   Zhinuo Jenny Wang, Maxx Holmes ... Blanca Rodriguez
6. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Overflow metabolism originates from growth optimization and cell heterogeneity

   Xin Wang

   The combination of growth optimization and cell heterogeneity enables a quantitative explanation of overflow metabolism in microbes and the classical Warburg effect in cancer cells, resolving this long-standing puzzle.
7. 1. Computational and Systems Biology

   Dynamical mechanisms of growth-feedback effects on adaptive gene circuits

   Ling-Wei Kong, Wenjia Shi ... Ying-Cheng Lai

   Systematic simulations reveal how growth feedback undermines the stability of adaptive gene circuits in a topology-dependent manner.
8. 1. Computational and Systems Biology

   Pathway activation model for personalized prediction of drug synergy

   Quang Thinh Trac, Yue Huang ... Trung Nghia Vu

   Drug synergy Interaction Prediction improves personalized drug synergy prediction by utilizing drug-specific pathway activation scores to predict personalized drug synergy and reveals mechanistic pathways underlying synergistic effects.
9. 1. Computational and Systems Biology

   Predicting the effect of CRISPR-Cas9-based epigenome editing

   Sanjit Singh Batra, Alan Cabrera ... Yun S Song
10. 1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Reliable protein–protein docking with AlphaFold, Rosetta, and replica exchange

    Ameya Harmalkar, Sergey Lyskov, Jeffrey J Gray

    New protein-protein docking algorithm combining deep learning (AlphaFold2) and physics (Rosetta and enhanced sampling) achieves high success rates.