Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Neuroscience

   Sex differences in learning from exploration

   Cathy S Chen et al.

   A new computational analysis of decision making in mice shows sex biases in value-updating while exploring unknown options, with male mice tending to explore longer than females due to updating values more slowly.
2. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Predicting bacterial promoter function and evolution from random sequences

   Mato Lagator et al.

   An inferred mechanistic model that connects sequence (genotype) to function (constitutive gene expression phenotype) for any random sequence in Escherichia coli reveals the structure of constitutive promoters and how they evolve.
3. 1. Computational and Systems Biology
   2. Medicine

   Personalized computational heart models with T1-mapped fibrotic remodeling predict sudden death risk in patients with hypertrophic cardiomyopathy

   Ryan P O'Hara et al.

   Personalized virtual-heart technology for arrhythmia risk assessment could transform the management of hypertrophic cardiomyopathy patients, eliminating many unnecessary primary-prevention defibrillator deployments while ensuring patients at high risk for arrhythmia are adequately protected.
4. 1. Computational and Systems Biology
   2. Neuroscience

   Human interictal epileptiform discharges are bidirectional traveling waves echoing ictal discharges

   Elliot H Smith et al.
5. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   Comprehensive interrogation of the ADAR2 deaminase domain for engineering enhanced RNA editing activity and specificity

   Dhruva Katrekar et al.
6. 1. Computational and Systems Biology
   2. Neuroscience

   Hippocampal sharp wave-ripples and the associated sequence replay emerge from structured synaptic interactions in a network model of area CA3

   András Ecker et al.
7. 1. Computational and Systems Biology
   2. Neuroscience

   An image reconstruction framework for characterizing initial visual encoding

   Ling-Qi Zhang et al.
8. 1. Computational and Systems Biology
   2. Medicine

   A human-based multi-gene signature enables quantitative drug repurposing for metabolic disease

   James A Timmons et al.

   Optimising the use of transcriptomics enables screening of thousands of compounds and illustrates an approach that yields quantitative pharmacology at the single-gene and pathway level.
9. 1. Computational and Systems Biology
   2. Medicine

   Data mining methodology for response to hypertension symptomology—application to COVID-19-related pharmacovigilance

   Xuan Xu et al.

   Quantitative models and data-driven approaches developed for the COVID-19 pandemic and predicting SARS-Cov-2 comorbidities for high-risk populations including hypertension show that the future of large-scale biomedical science will be significantly underscored by data-driven decision-making and AI knowledge-based development and validation.
10. 1. Computational and Systems Biology

    Response to comment on ‘SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung’

    Alan E Mast et al.

    We are writing to respond to the comment by FitzGerald and Jamieson, 2022 on our article about the drivers of coagulopathy in the lungs of COVID-19 patients (Mast et al., 2021).