Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Neuroscience

   Antagonism in olfactory receptor neurons and its implications for the perception of odor mixtures

   Gautam Reddy et al.

   Computational and theoretical analyses offer novel and unexpected insight into how complex, naturally occurring odor mixtures are parsed and normalized at the very first stage of olfaction.
2. 1. Computational and Systems Biology

   HIF-2α is essential for carotid body development and function

   David Macias et al.
3. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Computer-guided design of optimal microbial consortia for immune system modulation

   Richard R Stein et al.
4. 1. Computational and Systems Biology
   2. Structural Biology and Molecular Biophysics

   Free energy simulations reveal molecular mechanism for functional switch of a DNA helicase

   Wen Ma et al.
5. 1. Computational and Systems Biology

   The genetic landscape of a physical interaction

   Guillaume Diss, Ben Lehner

   First comprehensive analysis of how many different mutations combine within and between two genes to alter a molecular phenotype.
6. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   Incomplete inhibition of HIV infection results in more HIV infected lymph node cells by reducing cell death

   Laurelle Jackson et al.

   Under conditions where the force of HIV infection per cell is high, partial attenuation of infection with inhibitors can increase the number of live infected cells and may paradoxically be beneficial for viral spread.
7. 1. Computational and Systems Biology
   2. Chromosomes and Gene Expression

   Stochastic tuning of gene expression enables cellular adaptation in the absence of pre-existing regulatory circuitry

   Peter L Freddolino et al.
8. 1. Cell Biology
   2. Computational and Systems Biology

   Integrating images from multiple microscopy screens reveals diverse patterns of protein subcellular localization change

   Alex X Lu et al.
9. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   A robust and tunable mitotic oscillator in artificial cells

   Ye Guan et al.
10. 1. Cell Biology
    2. Computational and Systems Biology

    Size uniformity of animal cells is actively maintained by a p38 MAPK-dependent regulation of G1-length

    Shixuan Liu et al.

    The p38 MAPK pathway functions downstream of a cell-size-sensing process to coordinate cell size/growth with G1 progression in animal cells.