Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Longitudinal analysis of invariant natural killer T cell activation reveals a cMAF-associated transcriptional state of NKT10 cells

   Harry Kane, Nelson M LaMarche ... Lydia Lynch
2. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Evaluation of in silico predictors on short nucleotide variants in HBA1, HBA2 and HBB associated with haemoglobinopathies

   Stella Tamana, Maria Xenophontos ... Petros Kountouris
3. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Macroscopic control of cell electrophysiology through ion channel expression

   Mario García-Navarrete, Merisa Avdovic ... Krzysztof Wabnik

   A combination of mathematical modeling and live-cell imaging reveals a strategy for the rational control over cell electrophysiology though modulation of ion channel expression.
4. 1. Computational and Systems Biology
   2. Developmental Biology

   Deep proteome profiling reveals signatures of age and sex differences in paw skin and sciatic nerve of naïve mice

   Feng Xian, Julia Regina Sondermann ... Manuela Schmidt

   Proteomics uncovers thus far unknown age and sex differences in sciatic nerve and skin of naïve mice, highlighting the importance of adequate age matching and parallel investigation of male and female mice in biomedical studies.
5. 1. Cancer Biology
   2. Computational and Systems Biology

   Single-cell transcriptomics identifies Keap1-Nrf2 regulated collective invasion in a Drosophila tumor model

   Deeptiman Chatterjee, Caique Almeida Machado Costa ... Wu-Min Deng

   Comprehensive transcriptomic analyses describe the underlying tumorigenic gene expression state in the invasive Drosophila follicle cells following the loss of epithelial cell polarity and identify a non-canonical role of Keap1-Nrf2 signaling in regulating collective cell invasion.
6. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Evolution and regulation of microbial secondary metabolism

   Guillem Santamaria, Chen Liao ... Joao B Xavier

   Strains of the bacterium Pseudomonas aeruginosa that use secondary metabolism to make surfactants and change the surface tension of the liquid that surrounds them do so only if they can first meet their primary metabolic needs.
7. 1. Computational and Systems Biology
   2. Developmental Biology

   Large-scale analysis and computer modeling reveal hidden regularities behind variability of cell division patterns in Arabidopsis thaliana embryogenesis

   Elise Laruelle, Katia Belcram ... Philippe Andrey

   Self-organization based on a feedback loop between cell geometry and division plane positioning plays a central role in the building of tissue architectures in Arabidopsis thaliana embryo through both stereotyped and variable division patterns.
8. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Metrics of high cofluctuation and entropy to describe control of cardiac function in the stellate ganglion

   Nil Z Gurel, Koustubh B Sudarshan ... Olujimi A Ajijola
9. 1. Computational and Systems Biology
   2. Neuroscience

   Self-configuring feedback loops for sensorimotor control

   Sergio Oscar Verduzco-Flores, Erik De Schutter

   Learning to reach in the sensorimotor loop, and the required neural dynamics, can be potentially explained by simple principles.
10. 1. Computational and Systems Biology
    2. Immunology and Inflammation

    T cell receptor convergence is an indicator of antigen-specific T cell response in cancer immunotherapies

    Mingyao Pan, Bo Li

    Amino acid codon degeneracy indicates antigen-specific selection of the T cell receptors and is predictive of cancer immunotherapy outcomes.