Computational and Systems Biology

Computational and Systems Biology

eLife reviews research involving the use of methods, models and software. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Computational and Systems Biology

    Thymic selection of the T cell receptor repertoire is biased toward autoimmunity in females

    Hélène Vantomme, Valentin Quiniou ... David Klatzmann
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Developmental Biology
    2. Computational and Systems Biology

    Anti-resonance in developmental signaling regulates cell fate decisions

    Samuel J Rosen, Olivier Witteveen ... Maxwell Z Wilson
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Computational and Systems Biology
    2. Neuroscience

    A dynamic scale-mixture model of motion in natural scenes

    Jared M Salisbury, Stephanie E Palmer
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Evolutionary remodeling of non-canonical ORF translation in mammals

    Yue Chang, Tianyu Lei ... Hong Zhang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Computational and Systems Biology
    2. Neuroscience

    The electrogenicity of the Na+/K+-ATPase poses challenges for computation in highly active spiking cells

    Liz Weerdmeester, Jan-Hendrik Schleimer, Susanne Schreiber
    The electrogenic Na+/K+-ATPase generates a slow activity-dependent feedback signal that influences the computation of excitable cells and requires additional compensatory mechanisms during periods of high sustained activity.
    1. Computational and Systems Biology
    2. Developmental Biology

    MorphoNet 2.0: An innovative approach for qualitative assessment and segmentation curation of large-scale 3D time-lapse imaging datasets

    Benjamin Gallean, Tao Laurent ... Emmanuel Faure
    A collaborative open-source platform enabling interactive 3D visualization, quantitative evaluation, and expert curation of complex biological morphologies to enhance the quality and reproducibility of large-scale imaging studies.
    1. Computational and Systems Biology

    Nonlinear transcriptional responses to gradual modulation of transcription factor dosage

    Júlia Domingo, Mariia Minaeva ... Tuuli Lappalainen
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Computational and Systems Biology

    TSvelo: Comprehensive RNA velocity by modeling the cascade of gene regulation, transcription and splicing

    Jiachen Li, Zhe Wang ... Ye Yuan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Computational and Systems Biology

    Learning sequence-function relationships with scalable, interpretable Gaussian processes

    Juannan Zhou, Carlos Martí-Gómez ... David M McCandlish
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Computational and Systems Biology

    Knock-down of a regulatory barcode shifts macrophage polarization destination from M1 to M2 and increases pathogen burden upon S. aureus infection

    Sathyabaarathi Ravichandran, Bharat Bhatt ... Nagasuma Chandra
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
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Highlights

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

    Submit to our latest special issue in systems genetics

    1. Cancer Biology
    2. Computational and Systems Biology

    eLife publishes final papers from the Reproducibility Project: Cancer Biology

    Timothy M Errington, Maya Mathur ... Brian A Nosek
    1. Computational and Systems Biology

    International aspects of bioRxiv preprints

    Richard J Abdill, Elizabeth M Adamowicz, Ran Blekhman

Senior editors

  1. Alan Moses
    University of Toronto, Canada
  2. Aleksandra Walczak
    Ecole Normale Superieure, France
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