Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Methylation clocks fail to generalize across genetically admixed individuals

   Sebastián Cruz-Gonzalez, Ogechukwu Okpala ... John A Capra

   DNA-methylation-based predictors of biological age often fail to generalize across human populations, limiting their utility as biomarkers of aging and disease.
2. 1. Neuroscience
   2. Computational and Systems Biology

   Structured stabilization in recurrent neural circuits through inhibitory synaptic plasticity

   Dylan Festa, Claudia Cusseddu, Julijana Gjorgjieva
3. 1. Computational and Systems Biology

   Benchmarking biochemical networks generated by large language models

   Jeevan Tewari, Benjamin W Dahl ... Jeffrey J Saucerman

   Current general-purpose large language models generate signaling and metabolic networks with only modest accuracy relative to manually curated network models.
4. 1. Computational and Systems Biology
   2. Neuroscience

   Dichotomy between extracellular signatures of active dendritic chemical synapses and gap junctions

   Richa Sirmaur, Rishikesh Narayanan

   Fundamental distinctions in the extracellular signatures of active-dendritic chemical and electrical synapses necessitate a revision of conventional interpretations of local field potentials centered on chemical synapses.
5. 1. Developmental Biology
   2. Computational and Systems Biology

   Single-cell spatial mapping reveals reproducible cell type organization and spatially-dependent gene expression in gastruloids

   Catherine G Triandafillou, Pranav Sompalle ... Arjun Raj
6. 1. Computational and Systems Biology

   TSvelo: Comprehensive RNA velocity by modeling the cascade of gene regulation, transcription and splicing

   Jiachen Li, Zhe Wang ... Ye Yuan
7. 1. Computational and Systems Biology
   2. Neuroscience

   Active dendrites enable robust spiking computations despite timing jitter

   Thomas SJ Burger, Michael E Rule, Timothy O'Leary

   The brain computes rapidly and reliably using brief electrical impulses and likely exploits internal memory in nerve cells to achieve this more efficiently than existing computing hardware and neural networks.
8. 1. Computational and Systems Biology

   Permute-match tests detect significant correlations between time series despite nonstationarity and limited replicates

   Alex E Yuan, Wenying Shou
9. 1. Computational and Systems Biology

   Functional muscle networks as biomarkers of post-stroke motor impairment and therapeutic responsiveness

   David O'Reilly, Giorgia Pregnolato ... Giacomo Severini

   The proposed muscle network analysis framework identifies a redundancy-to-synergy shift as a marker of stroke recovery, yielding new biomarkers that could objectively quantify functional impairment and rehabilitation efficacy.
10. 1. Computational and Systems Biology

    Large-scale synthetic data enable digital twins of human excitable cells

    Pei-Chi Yang, Mao-Tsuen Jeng ... Colleen E Clancy

    Large-scale synthetic datasets enable construction of digital twins of individual human excitable cells from a single voltage-clamp recording.