Computational and Systems Biology

Computational and Systems Biology

eLife reviews research involving the use of methods, models and software. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Computational and Systems Biology
    2. Neuroscience

    Multilayer brain networks can identify the epileptogenic zone and seizure dynamics

    Hossein Shahabi, Dileep R Nair, Richard M Leahy
    Aging and the duration of epilepsy can intensify the high-frequency desynchronization between the epileptogenic zone and the rest of the brain in early to mid-seizure.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    The potential of integrating human and mouse discovery platforms to advance our understanding of cardiometabolic diseases

    Aaron W Jurrjens, Marcus M Seldin ... Anna C Calkin
    The benefits of integrating cross-species systems genetics platforms to advance knowledge in the underlying mechanisms that drive cardiometabolic diseases have been investigated.
    1. Computational and Systems Biology

    ProteInfer, deep neural networks for protein functional inference

    Theo Sanderson, Maxwell L Bileschi ... Lucy J Colwell
    A machine learning model predicts the properties of proteins from their amino acid sequences and can run in a user's web browser.
    1. Computational and Systems Biology

    Generative power of a protein language model trained on multiple sequence alignments

    Damiano Sgarbossa, Umberto Lupo, Anne-Florence Bitbol
    An iterative procedure using language models allows the generation of sequences from protein families, which score similarly to natural and experimentally validated sequences, with particular promise for small families.
    1. Cancer Biology
    2. Computational and Systems Biology

    Interrogating the precancerous evolution of pathway dysfunction in lung squamous cell carcinoma using XTABLE

    Matthew Roberts, Julia Ogden ... Carlos Lopez-Garcia
    XTABLE is the first easy-to-use bioinformatic solution that has been conceived and designed solely to interrogate the transcriptomes of premalignant stages of lung squamous cell carcinoma (LUSC) and enhance the development of LUSC prevention and detection strategies.
    1. Computational and Systems Biology
    2. Neuroscience

    Optimization of energy and time predicts dynamic speeds for human walking

    Rebecca Elizabeth Carlisle, Arthur D Kuo
    Humans often walk in relatively brief bouts whose speed and duration vary dynamically and satisfy an optimal trade-off between effort and time.
    1. Computational and Systems Biology

    Dynamics of co-substrate pools can constrain and regulate metabolic fluxes

    Robert West, Hadrien Delattre ... Orkun S Soyer
    Mathematical analyses explore the impact of co-substrate cycling on the dynamics of cellular metabolism, and demonstrate that these dynamics can limit cellular fluxes and that co-substrate pool dynamics can be regulated to regulate fluxes.

Senior editors

  1. Christian R Landry
    Université Laval, Canada
  2. Aleksandra Walczak
    Ecole Normale Superieure, France
  3. See more editors