Computational and Systems Biology

Computational and Systems Biology

eLife publishes research involving the use of methods, models and software. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Computational and Systems Biology

    Integrative small and long RNA omics analysis of human healing and nonhealing wounds discovers cooperating microRNAs as therapeutic targets

    Zhuang Liu et al.
    A comprehensive microRNA expression and function landscape of human wounds unraveled miRNAs highly relevant to venous ulcer pathology.
    1. Computational and Systems Biology
    2. Neuroscience

    Information flows from hippocampus to auditory cortex during replay of verbal working memory items

    Vasileios Dimakopoulos et al.
    Precisely tracking the anatomical sources of neural computations infers functional directed connectivity between hippocampal memory neurons and cortical sensory neurons, it reveals information flowing from cortex to hippocampus during encoding but the reverse direction during maintenance.
    1. Computational and Systems Biology
    2. Ecology

    Fermentation: Teaming up to make kombucha

    Olga Ponomarova
    Reducing the microbial diversity in a type of fermented tea reveals the core metabolic interactions responsible for the drink’s signature taste and characteristics.
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    1. Computational and Systems Biology
    2. Ecology

    A systematic, complexity-reduction approach to dissect the kombucha tea microbiome

    Xiaoning Huang et al.
    Kombucha tea microbiome analysis demonstrates the identification, characterization and extrapolation of minimal cores as a promising framework for mechanistic investigation of microbiome behaviors.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Large protein complex interfaces have evolved to promote cotranslational assembly

    Mihaly Badonyi, Joseph A Marsh
    Analysis of protein interfaces suggests cotranslational assembly can be an adaptive process, likely serving to minimise non-specific interactions with other proteins in the cell.
    1. Computational and Systems Biology
    2. Medicine

    Modeling osteoporosis to design and optimize pharmacological therapies comprising multiple drug types

    David J Jörg et al.
    A mathematical model of osteoporosis explains why the sequence of osteoporosis medications matters for short-term and long-term treatment success.
    1. Computational and Systems Biology
    2. Neuroscience

    A computational account of why more valuable goals seem to require more effortful actions

    Emmanuelle Bioud et al.
    Behavioural evidence and computational analyses suggest that people tend to decline the pursuit of more rewarded goals because they, wrongly, expect them to require more effortful actions.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Towards a unified model of naive T cell dynamics across the lifespan

    Sanket Rane et al.
    Naive CD4 and CD8 T cells in mice increase their survival capacity with age, but their numbers are not homeostatically regulated.