Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   An evolutionary recent IFN-IL-6-CEBP axis is linked to monocyte expansion and tuberculosis severity in humans

   Murilo Delgobo et al.
2. 1. Computational and Systems Biology
   2. Evolutionary Biology

   ASPEN, a methodology for reconstructing protein evolution with improved accuracy using ensemble models

   Roman Sloutsky, Kristen M Naegle

   Using different sets of input sequences to evolutionary reconstruction algorithms results in the exploration of many possible models, the intergration over which produces significantly more accurate models.
3. 1. Computational and Systems Biology
   2. Stem Cells and Regenerative Medicine

   Self-assembling manifolds in single-cell RNA sequencing data

   Alexander J Tarashansky et al.

   An iterative self-assembling algorithm identifies the intrinsic structures in single-cell transcriptomic data and helps to discover new cell populations that are undetectable by existing methods.
4. 1. Computational and Systems Biology
   2. Neuroscience

   Rats exhibit similar biases in foraging and intertemporal choice tasks

   Gary A Kane et al.

   In both foraging and intertemporal choice tasks, rats prefer immediate rewards to delayed rewards, and this preference can be explained by a form of hyperbolic discounting.
5. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   Bacterial survival in microscopic surface wetness

   Maor Grinberg et al.
6. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Epistasis and entrenchment of drug resistance in HIV-1 subtype B

   Avik Biswas et al.

   Drug resistance in HIV is the result of mutations, which affect fitness depending on epistatic interactions with the entire sequence background that varies within and between patient populations.
7. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Adaptation to mutational inactivation of an essential gene converges to an accessible suboptimal fitness peak

   João V Rodrigues, Eugene I Shakhnovich
8. 1. Computational and Systems Biology
   2. Developmental Biology

   Size control of the inner ear via hydraulic feedback

   Kishore R Mosaliganti et al.

   Size regulation of the otic vesicle, the progenitor of the inner ear, is mediated by mechanical feedback involving fluid influx, hydraulic pressure, and tissue mechanics.
9. 1. Computational and Systems Biology
   2. Neuroscience

   Population adaptation in efficient balanced networks

   Gabrielle J Gutierrez, Sophie Denève

   Neural populations may depend on balanced recurrent connectivity to produce an efficient stimulus representation while also maintaining an accurate stimulus encoding despite the variability introduced by adapting neural responses.
10. 1. Cell Biology
    2. Computational and Systems Biology

    Remote control of microtubule plus-end dynamics and function from the minus-end

    Xiuzhen Chen et al.

    A mechanism for yeast centrosomes to differentiate the microtubule cytoskeleton.