Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Neuroscience

   Tuning movement for sensing in an uncertain world

   Chen Chen et al.

   Animals work in a world full of surprises, where using energy to position sensors proportional to the location's expected information avoids the pitfalls of positioning them at the information maxima.
2. 1. Computational and Systems Biology

   Spectral clustering of risk score trajectories stratifies sepsis patients by clinical outcome and interventions received

   Ran Liu et al.

   Spectral clustering applied to risk trajectories of sepsis patients discovered four distinct clusters stratified by risk of septic shock, mortality, and treatments received prior to an abrupt physiological transition.
3. 1. Computational and Systems Biology

   Inherent regulatory asymmetry emanating from network architecture in a prevalent autoregulatory motif

   Md Zulfikar Ali et al.

   Network architecture and physiological features of the cell dictate asymmetric gene regulation between a negative autoregulatory TF gene and its target gene.
4. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Genetic mapping of etiologic brain cell types for obesity

   Pascal N Timshel et al.

   Unbiased computational integration of single-cell- and human genetics data shows that susceptibility to obesity is driven by a broad set of neuronal populations across the brain.
5. 1. Computational and Systems Biology

   Removing unwanted variation with CytofRUV to integrate multiple CyTOF datasets

   Marie Trussart et al.

   CytofRUV is a computational algorithm that effectively enables batch effect reduction in multiple CyTOF batches with an adaptable normalisation method and an R-Shiny application with diagnostics plots.
6. 1. Cell Biology
   2. Computational and Systems Biology

   The transcriptomic response of cells to a drug combination is more than the sum of the responses to the monotherapies

   Jennifer EL Diaz et al.
7. 1. Computational and Systems Biology

   Cell-cycle-gated feedback control mediates desensitization to interferon stimulation

   Anusorn Mudla et al.

   Cell cycle gating enables a temporal compartmentalization of negative vs positive feedback control processes, leading to differential responses to repetitive interferon stimulations.
8. 1. Chromosomes and Gene Expression
   2. Computational and Systems Biology

   Coverage-dependent bias creates the appearance of binary splicing in single cells

   Carlos F Buen Abad Najar et al.

   Sequencing and counting RNAs from single cells can create a misleading picture of alternative splicing if too many mRNAs are lost in the process.
9. 1. Computational and Systems Biology
   2. Neuroscience

   Training deep neural density estimators to identify mechanistic models of neural dynamics

   Pedro J Gonçalves et al.
10. 1. Computational and Systems Biology
    2. Physics of Living Systems

    Social interactions drive efficient foraging and income equality in groups of fish

    Roy Harpaz, Elad Schneidman

    Analysis and modeling of group behavior of adult zebrafish shows that a specialized social interaction mechanism increases foraging efficiency and equality within groups, under a variety of environmental conditions.