Computational and Systems Biology

Computational and Systems Biology

eLife publishes research involving the use of methods, models and software. Decisions are made by journal editors who are active researchers in computational and systems biology.
Illustration by Davide Bonazzi

Latest articles

    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Inter-species population dynamics enhance microbial horizontal gene transfer and spread of antibiotic resistance

    Robert M Cooper et al.
    Killing their neighbors allows bacteria to steal genes, including antibiotic resistance genes, which we observed under a microscope, quantified, modeled, and predicted potentially guiding strategies to combat it.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Horizontal Gene Transfer: Learning from losers

    Benjamin Kirkup
    Bacteria can overcome environmental challenges by killing nearby bacteria and incorporating their DNA.
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    1. Computational and Systems Biology
    2. Neuroscience

    The formation of the light-sensing compartment of cone photoreceptors coincides with a transcriptional switch

    Janine M Daum et al.
    Correlating changes in structure and gene expression in cone photoreceptors of mice daily, between birth and eye opening, created a resource that supports research in photoreceptor function, development, transplantation and repair.
    1. Computational and Systems Biology

    CDK9-dependent RNA polymerase II pausing controls transcription initiation

    Saskia Gressel et al.
    CDK9 inhibition in human cells uncovers that Pol II pause duration regulates the frequency of productive transcription initiation.
    1. Computational and Systems Biology
    2. Developmental Biology and Stem Cells

    A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis

    Ajay Mishra et al.
    A combination of transcriptomics, proteomics and modelling identifies a network of interacting protein phosphatases that act as a biological switch to move cells from the stem cell compartment to the differentiated compartment in cultured human epidermis.
    1. Computational and Systems Biology
    2. Neuroscience

    Exploratory search during directed navigation in C. elegans and Drosophila larva

    Mason Klein et al.
    Crawling Drosophila larvae and C. elegans exhibit diffusive behavior alongside directed motion, and the dynamics of this navigation can be analyzed with techniques developed in understanding protein folding, using a Markov state model.

Senior editors

  1. Naama Barkai
    Naama Barkai
    Senior Editor
  2. Arup K Chakraborty
    Arup K Chakraborty
    Senior Editor
  3. Patricia Wittkopp
    Patricia Wittkopp
    Senior Editor
  4. See more editors