Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Neuroscience

   Multivariate stochastic volatility modeling of neural data

   Tung D Phan et al.

   Multivariate stochastic volatility models provide insights into understanding the dynamics and connectivity of neural signals during cognitive tasks.
2. 1. Biochemistry and Chemical Biology
   2. Computational and Systems Biology

   Profiling the Escherichia coli membrane protein interactome captured in Peptidisc libraries

   Michael Luke Carlson et al.

   Trapping of the cell envelope proteome into water-soluble peptidisc library allows high-throughput definition of the membrane protein interactome.
3. 1. Computational and Systems Biology
   2. Physics of Living Systems

   Self-organised segregation of bacterial chromosomal origins

   Andreas Hofmann et al.
4. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses

   Rachel A Gottschalk et al.

   Inflammatory dynamics are tailored to bacterial class through macrophage integration of microbial stimuli and cytokine feedback.
5. 1. Computational and Systems Biology

   Meta-Research: Use of the Journal Impact Factor in academic review, promotion, and tenure evaluations

   Erin C McKiernan et al.

   Almost a quarter of faculty evaluation documents from US and Canadian universities mention Journal Impact Factor and often imply that it measures research quality.
6. 1. Computational and Systems Biology
   2. Neuroscience

   Characterizing functional pathways of the human olfactory system

   Guangyu Zhou et al.

   Human primary olfactory cortical regions can be parcellated into anatomically distinct areas based on whole-brain functional connectivity profiles, suggesting distinct, parallel functional pathways in the human olfactory system.
7. 1. Computational and Systems Biology
   2. Developmental Biology

   Modularity, criticality, and evolvability of a developmental gene regulatory network

   Berta Verd et al.

   A new approach focusing on dynamic modularity helps overcome traditional challenges detecting modularity in complex adaptive systems.
8. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq

   Dylan Kotliar et al.

   A novel algorithm, consensus non-negative matrix factorization (cNMF), accurately identifies gene expression programs underlying cell-type identity and cellular activities from single-cell RNA-Seq data.
9. 1. Computational and Systems Biology
   2. Structural Biology and Molecular Biophysics

   Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation

   Jamie A Macpherson et al.

   Specific residues within an enzyme integrate allosteric inputs that originate from distinct ligand-binding pockets.
10. 1. Computational and Systems Biology
    2. Genetics and Genomics

    Proteome-wide signatures of function in highly diverged intrinsically disordered regions

    Taraneh Zarin et al.

    Widespread, rapidly evolving disordered regions contain molecular features that are preserved over evolution and are associated with specific biological functions.