Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Developmental Biology and Stem Cells

   A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning

   Qixuan Wang et al.

   Regional differences in activator and inhibitor signals alter hair cycle pace across mouse skin and produce unique fur renewal 'landscapes', with fastest renewal on the ventrum and slowest renewal on the ear pinnae.
2. 1. Computational and Systems Biology

   Systematic integration of biomedical knowledge prioritizes drugs for repurposing

   Daniel Scott Himmelstein et al.
3. 1. Computational and Systems Biology
   2. Genomics and Evolutionary Biology

   MicroCT-based phenomics in the zebrafish skeleton reveals virtues of deep phenotyping in a distributed organ system

   Matthew Hur et al.

   Deep skeletal phenotyping in adult zebrafish reveals enhanced sensitivity of phenomic patterns in discriminating mutant populations.
4. 1. Computational and Systems Biology
   2. Neuroscience

   Fundamental bound on the persistence and capacity of short-term memory stored as graded persistent activity

   Onur Ozan Koyluoglu et al.

   A fundamental lower-bound on memory recall precision, which declines with storage duration and number of stored items, is derived, and human performance is shown to be well-fit by this theoretical bound.
5. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   The cyanobacterial circadian clock follows midday in vivo and in vitro

   Eugene Leypunskiy et al.

   The cyanobacterial core clock tracks midday regardless of day length, which can be understood in terms of a model for how the environment alters the clock limit cycle.
6. 1. Biochemistry
   2. Computational and Systems Biology

   Computational design of environmental sensors for the potent opioid fentanyl

   Matthew J Bick et al.
7. 1. Biophysics and Structural Biology
   2. Computational and Systems Biology

   Lipids and ions traverse the membrane by the same physical pathway in the nhTMEM16 scramblase

   Tao Jiang et al.
8. 1. Computational and Systems Biology
   2. Neuroscience

   Regulation of sleep homeostasis by sexual arousal

   Esteban J Beckwith et al.
9. 1. Computational and Systems Biology
   2. Developmental Biology and Stem Cells

   Systems biology derived source-sink mechanism of BMP gradient formation

   Joseph Zinski et al.

   Embryo-wide quantitative analysis of BMP signaling in zebrafish embryos, combined with a mathematical model-based computational screen, challenges the prevailing model of an antagonist counter-gradient shaping the gastrula BMP morphogen gradient and supports an antagonist sink with BMP diffusion mechanism.
10. 1. Cancer Biology
    2. Computational and Systems Biology

    Defining the biological basis of radiomic phenotypes in lung cancer

    Patrick Grossmann et al.

    Radiomics allows automated quantification of the radiographic phenotype of a tumor across diverse patient cohorts and is connected to the underlying molecular pathway activities, which together determine the clinical outcome.