Computational and Systems Biology

Latest articles

1. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   ImmunoCluster provides a computational framework for the nonspecialist to profile high-dimensional cytometry data

   James W Opzoomer et al.

   ImmunoCluster permits nonspecialist users to interrogate liquid and imaging mass, and flow cytometry datasets, resolving novel layers of cellular heterogeneity and insight, as well as producing publishable outputs and figures.
2. 1. Computational and Systems Biology
   2. Medicine

   Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarction

   Muhammad Arif et al.
3. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses

   Stephan Wilmes et al.

   IL-27 exerts differential activation of STAT1 and STAT3 via IL-27Ra and GP130, respectively, leading to a kinetic decoupling of its gene expression program, which contributes to tune its immuno-modulatory activities.
4. 1. Computational and Systems Biology

   A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice

   Michael A Petr et al.

   A comprehensive cross-sectional assessment reveals functional decline in mice consistent with increased energetic cost of physical activity with age through metabolic rewiring in multiple organs.
5. 1. Computational and Systems Biology
   2. Ecology

   TRex, a fast multi-animal tracking system with markerless identification, and 2D estimation of posture and visual fields

   Tristan Walter, Iain D Couzin

   Being fast, memory efficient, easy to use, and with powerful integrated tools, TRex will lower barriers of entry into, and enable more ambitious approaches to, the quantitative study of behavior.
6. 1. Computational and Systems Biology

   Proteomic and transcriptomic profiling reveal different aspects of aging in the kidney

   Yuka Takemon et al.

   mRNA profiling alone provides an incomplete picture of molecular aging and examination of changes in proteins is essential to understand aging processes that are not transcriptionally regulated.
7. 1. Computational and Systems Biology
   2. Evolutionary Biology

   Mapping single-cell atlases throughout Metazoa unravels cell type evolution

   Alexander J Tarashansky et al.
8. 1. Computational and Systems Biology
   2. Microbiology and Infectious Disease

   Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3

   Francesco Beghini et al.

   The bioBakery 3 platform enables improved, integrated, and strain-level analysis of microbial communities from large-scale meta-omic data.
9. 1. Computational and Systems Biology
   2. Medicine

   Computational modeling identifies embolic stroke of undetermined source patients with potential arrhythmic substrate

   Savannah F Bifulco et al.
10. 1. Computational and Systems Biology

    Associations of topic-specific peer review outcomes and institute and center award rates with funding disparities at the National Institutes of Health

    Michael S Lauer et al.

    An analysis of peer review and funding outcomes of NIH research applications shows that funding disparities of topics preferred by African American Black investigators are not due to peer review preferences or biases.