Computational and Systems Biology

eLife publishes research involving the use of methods, models and software. Decisions are made by journal editors who are active researchers in computational and systems biology.

Latest articles

    1. Biophysics and Structural Biology
    2. Computational and Systems Biology

    Substrate transport and anion permeation proceed through distinct pathways in glutamate transporters

    Mary Hongying Cheng et al
    Novel evidence on the molecular determinants of the dual function, anion permeation and substrate transport, of excitatory amino acid transporters opens avenues toward illuminating how these transporters regulate synaptic function and contribute to neurological conditions.
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    1. Computational and Systems Biology
    2. Ecology

    Lotka-Volterra pairwise modeling fails to capture diverse pairwise microbial interactions

    Babak Momeni et al
    With mathematical modeling being an important source of insight for microbial communities, we may need to move beyond commonly-used pairwise models that do not capture microbial interactions.
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    1. Cell Biology
    2. Computational and Systems Biology

    Functional mapping of yeast genomes by saturated transposition

    Agnès H Michel et al
    A new method maps functional and structural features of yeast genomes with unprecedented ease and throughput, which allows identification of protein domains at the genome scale.
    Tools and Resources Updated
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    1. Computational and Systems Biology

    Distributing tasks via multiple input pathways increases cellular survival in stress

    Alejandro A Granados et al
    Single-cell experiments and mathematical modelling show that cellular signalling networks are vulnerable to trade-offs in speed versus accuracy, but that these vulnerabilities can be overcome by distributing the two tasks to different, although interacting, subnetworks.
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    1. Computational and Systems Biology
    2. Genes and Chromosomes

    RNA-dependent chromatin association of transcription elongation factors and Pol II CTD kinases

    Sofia Battaglia et al
    In vivo and in vitro elongation factor-RNA interaction data provide a missing link in understanding how processive elongation complexes are formed on active genes and disassembled at the end of genes.
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    1. Computational and Systems Biology
    2. Neuroscience

    Saccadic suppression as a perceptual consequence of efficient sensorimotor estimation

    Frédéric Crevecoeur, Konrad P Kording
    Neural computations necessary for efficient control of saccades capture the phenomenon of saccadic suppression, which suggests that neural resources are shared for perception and control.
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    1. Computational and Systems Biology

    Kinetic modeling predicts a stimulatory role for ribosome collisions at elongation stall sites in bacteria

    Michael A Ferrin, Arvind R Subramaniam
    Collision between ribosomes can cause dissociation of stalled ribosomes from messenger RNAs during the process of mRNA translation.
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