Computational and Systems Biology

Computational and Systems Biology

eLife reviews research involving the use of methods, models and software. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Computational and Systems Biology

    Protein generation with evolutionary diffusion: sequence is all you need

    Sarah Alamdari, Nitya Thakkar ... Kevin K Yang
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    Olfactory combinatorial coding supports risk-reward decision making in C. elegans

    Md Zubayer Hossain Saad, William G Ryan ... Bruce A Bamber
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Computational and Systems Biology

    Thymic selection of the T cell receptor repertoire is biased toward autoimmunity in females

    Hélène Vantomme, Valentin Quiniou ... David Klatzmann
    Sex-specific biases in thymic T cell receptor selection enrich female CD8 T cell repertoires for autoimmunity-associated self-antigens, helping explain women’s increased susceptibility to autoimmune diseases.
    1. Neuroscience
    2. Computational and Systems Biology

    Social Influence in Donation Behavior: The Effect of Mean, Variance, and Psychopathy

    Tao Jin, Shen Zhang ... Iris Vilares
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Quantifying microbial fitness in high-throughput experiments

    Justus Wilhelm Fink, Michael Manhart
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Designing biochemical circuits with tree search

    Pranav S Bhamidipati, Matthew Thomson
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Neuroscience
    2. Computational and Systems Biology

    Individual differences drive social hierarchies in male mouse societies

    Jonathan R Reinwald, Sarah Ghanayem ... Wolfgang Kelsch
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Computational and Systems Biology
    2. Cancer Biology

    dbGIST: An LLM-Assisted Multi-Omics Resource for Target Exploration and Cross-Dataset Validation in Gastrointestinal Stromal Tumors

    Zhao Sun, Qian Zhao ... Yang Fu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Combinatorial transcription factor interactions drive modular gene regulatory networks

    Jialei Duan, Boxun Li ... Gary C Hon
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Out-of-balance Growth Enables Cost-free Synthesis of the Flagellum and Other Proteins in a Single Bacterium

    Mayra Garcia-Alcala, Josiah C Kratz, Philippe Cluzel
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
Load more

Highlights

    1. Computational and Systems Biology
    2. Genetics and Genomics

    Wnt Signaling: Exploring the origins of a signaling pathway

    Balaji Santhanam
    1. Computational and Systems Biology

    Methylation: Modifying gene expression through passive forces

    Sarah Hallstein, Julian König
    1. Computational and Systems Biology

    Cellular Respiration: Mapping mitochondrial aging

    Alessandro Bitto

Senior editors

  1. Alan Moses
    University of Toronto, Canada
  2. Aleksandra Walczak
    Ecole Normale Superieure, France
  3. See more editors