Editors for Medicine
Senior editors
-
Matthias Barton
University of Zurich, Switzerland
Matthias Barton, MD, is a Professor of Cardiology at the University of Zurich. His clinical and investigative focus are general cardiology and preventive medicine, with a particular interest in coronary artery disease and myocardial infarction. His work explores mechanisms of atherosclerosis, heart disease in women, and vascular factors contributing to cardiovascular health and disease.
- Expertise
- Medicine
- Research focus
- cardiovascular medicine
- coronary artery disease
- vascular biology
- heart disease in women
- molecular medicine
- Competing interests statement
- Matthias Barton has received funding from the Swiss National Science Foundation and is on the editorial boards of the American Journal of Cardiovascular Disease, the American Journal of Physiology Regulatory Integrative & Comparative Physiology, Endocrine and Metabolic Science, Experimental Biology and Medicine, Arteriosclerosis, Thrombosis and Vascular Biology and Hypertension, official journals of the American Heart Association. He has been an elected ordinary member of the Academy of Europe (Academia Europaea) since 2017.
-
Christian Büchel
University Medical Center Hamburg-Eppendorf, Germany
Christian Büchel is a member of the Hamburg Center for Neuroscience in Hamburg, where he is also the Director of the Department for Systems Neuroscience at Hamburg University Medical Center. He holds an Affiliate Professor appointment in the Psychology department at the University of Hamburg. After Medical School at the University of Heidelberg, he performed postdoctoral research with Karl Friston as a Wellcome Research Fellow at the Wellcome Department of Imaging Neuroscience at UCL in London with a focus on effective connectivity.
Establishing his lab in Hamburg, he focused on the cognitive neuroscience of pain and motivation and initially studied decision making with an emphasis on delay discounting. In a parallel stream of projects he observed that the pain modulation underlying placebo analgesia can already be observed at the spinal cord level, a finding which he later also established for nocebo hyperalgesia. He is part of the IMAGEN study and during his time at Stanford he identified hypoactivation of reward circuits as a potential risk factor for addiction.
He is a member of the Academy of Science in Hamburg and was awarded the Jung Award for Medicine, the Gottfried Wilhelm Leibniz-Preis by the German Research Foundation, and the Wiley Young Investigator Award of the Organization for Human Brain Mapping for recognition of his work in cognitive neuroscience.
- Expertise
- Neuroscience
- Medicine
- Research focus
- cognitive neuroscience
- pain modulation
- decision-making
- fear
- anxiety
- addiction
- Experimental organism
- human
- Competing interests statement
- Christian Büchel has received research grants from the European Research Council, Deutsche Forschungsgemeinschaft and Bundesministerium für Bildung und Forschung. He serves on the board of reviewing editors of Science magazine. He serves on the Swiss National Research Council, the Scientific Advisory Board of the ICM in Paris and the Center for Behavioral Brain Sciences, Magdeburg, Germany.
-
Miles P Davenport
University of New South Wales, Australia
Miles Davenport is Professor of Medicine and Head of the Infection Analytics Program at the Kirby Institute for Infection and Immunity at UNSW Sydney. He graduated in medicine from the University of Sydney and completed his DPhil at the University of Oxford in immunology before retraining in mathematical biology. He leads a team of applied mathematicians who use statistical analysis and modelling to understand host-pathogen interactions in infection and immunity. This involves collaboration with a wide variety of experimental and clinical scientists both in Australian and internationally. Major areas of investigation include understanding HIV latency, malaria immunity and treatment, and neonatal immune development. He is a past-President of the Australasian Society for Immunology and is supported by an NHMRC (Australia) Investigator grant.
- Expertise
- Immunology and Inflammation
- Microbiology and Infectious Disease
- Epidemiology and Global Health
- Medicine
- Research focus
- virology
- immunity
- vaccines
- HIV/AIDS
- mathematical modelling
- host-pathogen interactions
- biostatistics
- Competing interests statement
- Miles Davenport receives funding from the National Health and Medical Research Council (Australia), the Australian Research Council, and the National Institutes of Health (USA). He is an Associate Editor at PLoS Computational Biology and on the Editorial Board of Immunology and Cell Biology.
-
Betty Diamond
The Feinstein Institute for Medical Research, United States
Betty Diamond received an MD from Harvard Medical School. She performed a residency in Internal Medicine at Columbia Presbyterian Medical Center, and then a post-doctoral fellowship in Immunology with Dr Matthew Scharff at the Albert Einstein College of Medicine. She is currently Director of the Institute of Molecular Medicine at the Feinstein Institute for Medical Research.
Dr Diamond’s research has focused on the induction and pathogenicity of anti-DNA antibodies in Systemic Lupus Erythematosus. She showed that somatic mutation of immunoglobulin genes can generate autoantibodies in mice and humans, making the germinal center a focus in disease pathogenesis. Her laboratory has also demonstrated that a subset of anti-DNA antibodies cross-reacts with the NMDA receptor and showed that autoantibodies can cause aspects of neuropsychiatric lupus, creating a paradigm for antibody-mediated changes in brain function in many conditions. Most recently, she has developed a research program on the immunomodulatory functions of C1q.
She received the Outstanding Investigator Award of the ACR in 2001, the Lee Howley Award from the Arthritis Foundation in 2002, and the Recognition Award from the National Association of MD-PhD Programs in 2004 and the AAI Distinguished Fellow Award in 2019. In 2006, she was elected to the Institute of Medicine and became a fellow of the AAAS. She has served on the Scientific Council of NIAMS and the Board of Directors of the American College of Rheumatology. She is a past President of the American Association of Immunologists.
- Expertise
- Medicine
- Immunology and Inflammation
- Research focus
- B cells
- systemic lupus
- neuropsychiatric lupus
- autoantibodies
- autoimmunity
- Experimental organism
- human
- mouse
- Competing interests statement
- Betty Diamond receives funding from the NIH, LuCIN (Lupus Clinical Investigators Network), Lupus Research Alliance, DOD Lupus and Leidos Biomedical Research, Inc.. She is the Chief Editor at Molecular Medicine and a Deputy Editor for Frontiers in Immunology.
-
Wafik S El-Deiry
Brown University, United States
Wafik El-Deiry, MD, PhD, FACP is Associate Dean for Oncologic Sciences at the Warren Alpert Medical School, Director, Cancer Center at Brown University, and Director of the Joint Program in Cancer Biology at Brown and Lifespan. He is a Professor of Pathology and Laboratory Medicine, Professor of Medical Science, and Mencoff Family University Professor at Brown. He sees patients in his weekly clinic at Rhode Island Hospital focused on care of patients with colorectal cancer and participates in clinical trials based on his laboratory’s research on novel therapeutics. He previously served as Deputy Director for Translational Research, co-Leader of the Molecular Therapeutics Program, Professor of Oncology, and the William Wikoff Smith Endowed Chair in Cancer Research at Fox Chase Cancer Center. From 2010 through 2014 Dr El-Deiry was the Rose Dunlap Professor of Medicine and Chief of Hematology-Oncology at Penn State. In 2009, El-Deiry became an American Cancer Society Research Professor. He was previously a tenured Professor of Medicine (Hematology-Oncology), Genetics, and Pharmacology at University of Pennsylvania, co-Leader of the Radiobiology and Imaging Program at the Abramson Cancer Center and Associate Director for Physician-Scientist Training in Hematology-Oncology when he left Penn in 2010. He earned MD/PhD degrees from University of Miami School of Medicine and completed internal medicine residency and medical oncology fellowship at the Johns Hopkins Hospital and the Johns Hopkins Oncology Center. As a practicing academic Oncologist, his scientific interest and expertise is in cell death, drug resistance in cancer and drug discovery and development. El-Deiry founded two companies, Oncoceutics, Inc. and p53-Therapeutics, Inc.
El-Deiry discovered p21(WAF1) as a p53 target gene, universal cell cycle inhibitor, and tumor suppressor gene that for the first time explained the mammalian cell stress response. He discovered TRAIL receptor DR5 and its regulation by p53. TRAIL is part of the host immune system that suppresses cancer and its metastases. His lab created a knock-out mouse for TRAIL receptor DR5 and this mouse is tumor prone and develops an inflammatory syndrome in the lungs and gut after sub-lethal irradiation. He identified c-Myc as a major determinant of TRAIL sensitivity and demonstrated synergy between TRAIL therapy and multi-kinase inhibitor sorafenib. Building on his prior accomplishments, El-Deiry discovered ONC201/TIC10 as a first-in-class TRAIL pathway inducer that is orally bioavailable and crosses the blood-brain barrier to treat brain tumors. TRAIL and Foxo3a are required for the anti-tumor effect of ONC201 through dual blockade of ERK and Akt kinases that promotes the nuclear translocation of the Foxo3a transcription factor which directly regulates the TRAIL gene. Data from El-Deiry’s lab identified that ONC201 induces TRAIL receptor DR5 through an integrated stress response involving ATF4 and CHOP transcription factors. Patients with among the most aggressive gliomas (H3K27M mutant DIPG) have had exceptional responses to ONC201.
As a physician-scientist, Dr El-Deiry has worked to bring new discoveries to the clinic. He is committed in the next phase of his career to unraveling the mechanisms involved in p53 pathway restoration by candidate therapeutics his lab has discovered. This is exciting as he is defining a novel class of anti-cancer drugs with p53 pathway restoration and S-phase checkpoint targeting and recognizing ATF4 as a major transcription factor mechanism for p53 pathway restoration in p53-null or p53 mutant tumor cells. He is establishing transcriptomic and proteomic data sets with chemotherapy that acts through p53, and with novel small molecules that restore the p53 pathway in p53-deficient or mutant p53 expressing cells. He is exploiting medicinal chemistry and organoid technologies to perform his translational science that is leading to clinical trials some of which he leads. Dr El-Deiry conducts basic and translational clinical oncology therapeutics research through funded NIH grants, Foundations and industry. He is a member of the ASCI, AAP, Past President of the Interurban Clinical Club, previous Chair of ASCO’s Tumor Biology Track, and past Chair of an NIH Study Section on Cancer Therapeutics. Dr El-Deiry has trained many students and post-doctoral fellows, physician-scientists, and continues to mentor junior scientists and faculty in basic and translational cancer research.
- Expertise
- Medicine
- Cancer Biology
- Research focus
- cancer
- tumor suppressor genes
- colorectal cancer
- p53 pathway
- cell death
- medical oncology
- drug development
- drug discovery
- p21(WAF1)
- ONC201/TIC10
- physician-scientist issues
- Experimental organism
- human
- mouse
- Competing interests statement
- Dr El-Deiry receives funding from the NIH/NCI, the Warren Alpert Foundation, and D&D Pharmatech. He is a Specialty Chief Editor for the Cancer Molecular Targets and Therapeutics Section of Frontiers in Oncology. He is also a Section Editor for Molecular Oncology and HemOnc Today. Dr El-Deiry is the scientific founder and shareholder of Oncoceutics, Inc.
and p53-Therapeutics, Inc.
-
Eduardo Franco
McGill University, Canada
Eduardo Franco is Professor and Chairman, Department of Oncology, and Director, Division of Cancer Epidemiology, McGill University, Montreal. He holds BSc (1975) and Licentiate (1976) degrees in biology from Universidade de Campinas, Brazil, and master's (MPH) and doctoral (DrPH) degrees in public health microbiology from the University of North Carolina at Chapel Hill (1981-84). He was a Guest Researcher at the US Centers for Disease Control in Atlanta (1980-81 and 1983-84), and a post-doctoral fellow in cancer epidemiology during 1984 at the International Agency for Research on Cancer in Lyon, France, at the US National Cancer Institute (NCI) in Bethesda, and at Louisiana State University, in New Orleans. Since 1985, he has conducted epidemiologic research on the causes of cancer and on the means to prevent it or to improve patient survival. He is mostly known for his contributions to our understanding of human papillomavirus infection as the cause of cervical cancer and using this knowledge to prevent this cancer via vaccination and improved screening strategies. He received the Canadian Cancer Research Alliance’s Distinguished Service to Cancer Research Award, Lifetime Achievement Awards from the American Society for Colposcopy and Cervical Pathology and from the International Papillomavirus Society, the Women in US Government’s Leadership Award, the Canadian Cancer Society’s Warwick Prize, the Geoffrey Howe Outstanding Contribution Award from the Canadian Society for Epidemiology and Biostatistics, the University of British Columbia’s Chew Wei Memorial Prize in Cancer Research, and the McLaughlin-Gallie Award from the Royal College of Physicians of Canada. He has mentored 115 graduate students and post-doctoral fellows, and 30 undergraduate trainees. He is Officer of the Order of Canada and Fellow of the Royal Society of Canada and of the Canadian Academy of Health Sciences. Heholds an honorary doctorate from Universidade Fernando Pessoa, Porto, Portugal.
- Expertise
- Cancer Biology
- Epidemiology and Global Health
- Medicine
- Research focus
- cancer epidemiology
- cancer prevention
- human papillomavirus
- cancer screening
- Experimental organism
- human
- Competing interests statement
- Entire research program funded by the Medical Research Council of Canada (until 1999), Canadian Institutes of Health Research (CIHR) (1999-present), National Institutes of Health, Canadian Cancer Society, and Cancer Research Society. He has received salary awards from the Fonds de Recherche Quebec Santé and CIHR. He holds a James McGill Professorship and the Minda de Gunzburg Endowed Chair at McGill University. He serves as Editor-in-Chief for Preventive Medicine and Preventive Medicine Reports and serves on the editorial boards of Cancer Epidemiology, Biomarkers & Prevention, International Journal of Cancer, Papillomavirus Research, and Salud Publica de Mexico. He has served as occasional consultant to companies involved with HPV vaccination (Merck and GSK) and HPV diagnostics (Roche, Abbott, Qiagen, and BD).
-
Wendy S Garrett
Harvard T.H. Chan School of Public Health, United States
Wendy Garrett is a Professor of Immunology and Infectious Diseases at the Harvard T. H. Chan School of Public Health, co-Director of the Harvard Chan Center for the Microbiome in Public Health, and an Associate Member of the Broad Institute. Her work explores host-microbiota interactions underlying mucosal immune homeostasis, gastrointestinal inflammatory disorders, and cancer. She graduated from the Yale College; received her MD PhD from Yale University and completed post-graduate training at Harvard.
- Expertise
- Immunology and Inflammation
- Microbiology and Infectious Disease
- Medicine
- Research focus
- host-microbiota interactions
- microbiome
- mucosal immunology
- Competing interests statement
- Wendy Garrett serves on advisory boards of Evelo Biosciences, Kintai Therapeutics, and Leap Therapeutics. She is a member of the Cell Reports and Journal of Clinical Microbiology editorial boards.
-
Diane M Harper
University of Michigan, United States
Diane M Harper, MD, MPH, MS, completed her undergraduate and graduate degrees at the Massachusetts Institute of Technology in Cambridge, Massachusetts, in the fields of Chemical Engineering and Polymerics. She received her medical and public health degrees from the University of Kansas in Kansas City, where she also did residencies in Gynecology/Obstetrics and Family Medicine. Dr Harper has spent the majority of her professional career at Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, as clinician, teacher and researcher in the Departments of Obstetrics and Gynecology, Community and Family Medicine and Women’s and Gender Studies, including improving life for LGBTQ.
She has received the Society of Teachers of Family Medicine (STFM) Excellence in Education Award and the Curtis Hames Research Award honoring her for changing medical care for women through evidence based research. She served as the Chair of Family and Geriatric Medicine at the University of Louisville during which time she also served on the United States Preventive Services Task Force.
She currently is a tenured Professor at the University of Michigan, serving as the Director for Research Management within the Michigan Institute of Clinical and Health Research, one of 50 Clinical and Translational Science Award Research Hubs across the United States. To date she has over 250 peer reviewed publications with over 27,000 citations, and over 40,000 downloads of her seminal review of HPV vaccines.
While at Dartmouth she developed and directed the Gynecologic Cancer Prevention Research Group based at the Norris Cotton Cancer Center in which research on all aspects of HPV associated diseases, specifically cervical cancer prevention was conducted. She is an internationally recognized expert on Human Papillomavirus, the cause of cervical cancer, and its prophylactic and therapeutic vaccines. She has published the sentinel clinical research on HPV vaccines and lectured internationally in over 100 countries. She has served on NCI research committees, European research study sections, addressed the Council on Foreign Affairs, and served as a technical advisor to the World Health Organization. Dr Harper has been honored as one of the top clinicians in her field in the US, and Family Physician of the Year in New Hampshire in 2006.
- Expertise
- Medicine
- Epidemiology and Global Health
- Microbiology and Infectious Disease
- Immunology and Inflammation
- Research focus
- HPV associated diseases
- primary care
- women's health
- cancer precursor detection
- health behaviours
- epidemiology
- cancer screening
- Experimental organism
- human
- Competing interests statement
- Diane Harper has received funding from NCI, NCATS, NHLBI, CDC, multiple national philanthropic organizations, including the American Cancer Society, The Robert Wood Johnson Foundation, and the Susan G Komen Foundation, in addition to state and local funding agencies and collaborations with industry. She serves in editorship capacities on boards including the Annals of Family Medicine, Preventive Medicine Reports, PLoS ONE, and Gynecologic Oncology. She is a peer reviewer for The Lancet, The New England Journal of Medicine, JAMA, among other journals.
-
Carlos Isales
Medical College of Georgia at Augusta University, United States
Carlos Isales is from San Juan, Puerto Rico, where he graduated from the University of Puerto Rico School of Medicine and did his residency in Internal Medicine at the San Juan Veterans Administration Hospital. He completed a fellowship in Endocrinology and Metabolism at Yale University School of Medicine working in a laboratory under Dr Howard Rasmussen. In 1993, he moved to the Medical College of Georgia in Augusta, GA to help establish the Institute of Molecular Medicine and Genetics. His work has focused on defining the impact of nutrients on bone metabolism and loss of nutrient sensing with aging leading to both bone and muscle loss. His group was among the first to characterize an entero-osseous axis linking incretin hormones and bone turnover. Current work is focused on defining the impact of oxidation of aromatic amino acids and downstream metabolites such as tryptophan-kynurenine on stem cell proliferation and differentiation and resultant age-related osteoporosis. He is currently Chief of the Division of Endocrinology and Metabolism at Augusta University, Regents’ Professor and J. Harold Harrison Distinguished University Chair in Healthy Aging. He is also the Clinical Director of the newly established Center for Healthy Aging. His research is funded by the National Institutes of Aging. He is also passionate about mentoring the next generation of scientists and is MPI on a training award from the National Institutes on Aging.
- Expertise
- Medicine
- Research focus
- aging
- stem cells
- epigenetics
- metabolic bone disease
- nutrition
- amino acid metabolism
- tryptophan metabolism
- Experimental organism
- human
- mouse
- Competing interests statement
- Carlos Isales is currently funded by the National Institute on Aging. He is co-founder of Gerologix, a company focused on developing countermeasures to musculoskeletal aging. He is currently Academic Editor for PLOS ONE and JBMR Plus.
-
Y M Dennis Lo
The Chinese University of Hong Kong, Hong Kong SAR China
Dennis Lo is the Li Ka Shing Professor of Medicine and Director of the Li Ka Shing Institute of Health Sciences at The Chinese University of Hong Kong. He received his BA (Hons) from the University of Cambridge and his Doctor of Medicine and Doctor of Philosophy degrees from the University of Oxford. He discovered the presence of cell-free fetal DNA in maternal plasma in 1997. He has since translated this finding into a platform for noninvasive prenatal testing (NIPT). He has also made concurrent discoveries and inventions in the liquid biopsies of cancer. In recognition of his work, he has been elected as a Fellow of the Royal Society (UK), Foreign Associate of the US National Academy of Sciences, Fellow of the World Academy of Sciences and a founding member of the Hong Kong Academy of Sciences. He is a recipient of the Breakthrough Prize in Life Sciences (2021).
- Expertise
- Medicine
- Genetics and Genomics
- Research focus
- molecular diagnostics
- prenatal diagnosis
- biomarkers in oncology
- clinical genomics
- noninvasive prenatal testing
- cancer screening with liquid biopsy
- Experimental organism
- human
- mouse
- Competing interests statement
- Research funding from the Hong Kong Research Grants Council, Innovation and Technology Commission and Li Ka Shing Foundation. Trustee of the Croucher Foundation. Commercial relationships including licensing, equity or consultancy: Grail, Illumina, Sequenom, Xcelom, DRA, Take2 and Decheng Capital. Associate editorship of journals: Clinical Chemistry, npj Genomic Medicine. Memberships of journal editorial boards: Journal of Pathology, Philosophical Transactions of the Royal Society B, Journal of Genomes and Exomes, Disease Markers and Marrow.
-
Jos WM van der Meer
Radboud University Medical Centre, Netherlands
Jos WM van der Meer is emeritus Professor of Medicine at Radboud University Nijmegen, The Netherlands. Between 1992 and 2012 he was head of the Department of internal medicine at the Radboud University Medical Centre. His major areas of expertise are host defence against infection, trained immunity, autoinflammation, immunodeficiency and antimicrobial policy.
- Expertise
- Medicine
- Microbiology and Infectious Disease
- Research focus
- infectious disease and host defense
- innate immunity
- trained immunity
- immunodeficiency
- autoinflammatory diseases
- chronic fatigue syndrome
- Experimental organism
- human
- mouse
- Competing interests statement
- Jos WM van der Meer is a member of the Royal Netherlands Academy of Arts and Sciences (KNAW), for which he served as a vice-president from 2005 to 2011. He is a member of Academia Europaea and he is past-president of EASAC, the European Academies Science Advisory Council. He is an honorary Fellow of the Royal College of Physicians in London and in Edinburgh and a fellow of the Infectious Diseases Society of America and of the European Society of Clinical Microbiology and Infectious diseases. He is a member of the Dutch National Board for Research Integrity LOWI. He received a number of prices and awards, such as the Gold Hijmans van den Bergh medal. He was awarded knighthood in the order of the Netherlands Lion in 2003.
-
Gary Westbrook
Vollum Institute, United States
Gary Westbrook is a Senior Scientist at the Vollum Institute and Rocky and Julie Dixon Professor of Neurology at Oregon Health & Science University. Dr. Westbrook is a member of the National Academy of Medicine (formerly Institute of Medicine), the American Academy of Arts and Sciences, and past editor-in-chief of the Journal of Neuroscience. He has received Javits and Merit awards from NIH for his research as well as an International Cooperation Award from the Max Planck Society. Dr. Westbrook received his medical training and did graduate study in Biomedical Engineering at Case Western Reserve University, followed by residencies in Internal Medicine and Neurology, and basic neuroscience research at the National Institutes of Health in Bethesda. Earlier work in his lab was mostly directed at the level of receptors, particularly N-methyl-D-aspartate (NMDA) receptors, and the function of single synapses. The emphasis has now largely shifted to studies of small networks (microcircuits) in the hippocampus. Dr. Westbrook maintains interests in clinical neurology, particularly epilepsy, as well as graduate research training. He was co-Director of the Vollum Institute (2005-2015) and director of the Neuroscience Graduate Program at Vollum/OHSU (2008-2018).
- Expertise
- Neuroscience
- Medicine
- Research focus
- synaptic transmission
- synaptic plasticity
- ligand-gated ion channels
- hippocampus
- olfactory bulb
- epilepsy
- in vitro physiology
- activity-dependent gene expression
- Experimental organism
- mouse
- Competing interests statement
- Gary Westbrook is employed by Oregon Health and Science University. He receives research and training funding from the National Institutes of Health and the Ellison Medical Foundation. He is a member of the National Academy of Medicine (formerly Institute of Medicine) and the American Academy of Arts and Sciences. He serves on Scientific Advisory Boards for Max Planck Institutes in Göttingen (MPIEM) and Florida (MPFI), the Myelin Repair Foundation, and on study sections for the National Institutes of Health. He is currently a member of editorial boards for Physiological Reviews and Philosophical Transactions of the Royal Society B.
-
Richard M White
Memorial Sloan Kettering Cancer Center, United States
Richard White, M.D., Ph.D, is a physician-scientist at the Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College. He is interested in basic mechanisms underlying metastasis, using the zebrafish as a model system. His work has established numerous techniques for cancer modeling and high-resolution imaging in the fish. Using these tools, the lab is focused on the cross-talk between tumor cells and the microenvironment, and how this interplay influences metastatic success. His work has revealed novel interactions between melanoma cells and adipocytes in the microenvironment, and how neural crest programs play roles in melanoma progression. He has been awarded the NIH Director’s New Innovator Award, the Pershing Square Foundation Award, and the Mark Foundation ASPIRE award.
- Expertise
- Cancer Biology
- Medicine
- Research focus
- metastasis
- melanocyte development
- neural crest
- melanoma
- adipocytes
- microenvironment
- melanocytes
- Experimental organism
- zebrafish
- Competing interests statement
- Richard White receives funding from the National Institutes of Health, the Pershing Square Sohn Foundation, the Mark Foundation, the Melanoma Research Alliance, the American Cancer Society and the Harry J. Lloyd Foundation. He receives consulting fees from N-of-One, Inc.
-
Mone Zaidi
Icahn School of Medicine at Mount Sinai, United States
Mone Zaidi graduated in medicine from King George’s Medical College, India, and trained clinically at the Hammersmith Hospital, London, under the tutelage of Iain MacIntyre, FRS. After obtaining a PhD and MD from the University of London, Dr Zaidi held appointments as Lecturer at the Royal Postgraduate Medical School and Senior Lecturer and Honorary Consultant at St. George’s Hospital Medical School for over 8 years. In 1999, he moved to Mount Sinai School of Medicine in New York as Professor of Medicine and Founding Director of The Mount Sinai Bone Program. Zaidi has discovered mechanisms of skeletal homeostasis in health and its dysregulation in common and rare diseases. These studies, spanning over 30 years, included the first description of calcium sensing in the osteoclast and the discovery that locally released nitric oxide acts to suppress bone removal. In 2003, his group published evidence for a pituitary–bone axis of medical significance, in which pituitary hormones affect the skeleton directly. More recently, he found that inhibiting FSH not only increased bone mass, but also reduced body fat and increased thermogenesis – in essence, laying the firm foundation for his new humanized monoclonal FSH antibody to treat both osteoporosis and obesity. This corpus of work was selected by Nature Medicine as one of eight “Notable Advances” in biomedicine for 2017. Zaidi’s research was funded by the Medical Research Council of the UK, and since 1997, by the US National Institutes of Health. He is an elected member of the American Society for Clinical Investigation, Association of American Physicians, the Interurban Clinical Club (established by Sir William Osler in 1905) of which he was President, the Practitioners’ Society of New York (the oldest medical society in the US), and the Association of Professors of Medicine. Zaidi was made Master of the American College of Physicians, received the Harrington Scholar-Innovator Award, was elected as Fellow of the American Association of Advancement of Science, and is recipient of three honorary doctorates.
- Expertise
- Medicine
- Research focus
- osteoporosis
- obesity
- bone mass
- metabolism
- adipose tissue
- endocrine physiology
- pituitary hormones
- FSH
- Competing interests statement
- Mone Zaidi is currently funded by the National Institute on Aging and the National Institute of Diabetes, Digestive and Kidney Diseases of the NIH. He is inventor on several patents in relation to his work on FSH, bone and body composition. He is currently Consulting Editor for the Journal of Clinical Investigation, Editor of a series – Marrow – of the Annals of the New York Academy of Sciences, and Editor-in-chief of the Encyclopedia of Bone Biology, published by Elsevier as their Major Reference Works.
-
Huda Zoghbi
Baylor College of Medicine and Texas Children's Hospital, United States, United States
Huda Zoghbi is Professor of Pediatrics, Neurology, Molecular and Human Genetics, and Neuroscience at Baylor College of Medicine, Houston, Texas. She is also an Investigator with the Howard Hughes Medical Institute and Director of the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital. Her research focuses on understanding normal brain development and on elucidating the pathogenesis of several neurological disorders including the autism spectrum disorder, Rett syndrome, and late-onset neurodegenerative diseases.
- Expertise
- Neuroscience
- Genetics and Genomics
- Medicine
- Research focus
- neurobiology of disease
- neurodegeneration
- autism
- ataxia
- Experimental organism
- human
- mouse
- Competing interests statement
- Huda Zoghbi is actively receiving funds from the Howard Hughes Medical Institute, the National Institutes of Health, Rett Syndrome Research Trust, International Rett syndrome Foundation (and she is a member of advisory panels for all four organizations), Baylor College of Medicine, and Texas Children’s Hospital. She is Editor-in-chief of Annual Reviews of Neuroscience and a member of the editorial team of Cell and Neuron. She is immediate past President of the McKnight Neuroscience Fund and a member of the following Scientific Advisory Panels: Shaw Prize Jury, Breakthrough Prize Jury, and Vilcek Prize Jury; and a member of the Scientific Advisory Board of Denali Therapeutics and The Column Group. She is also a member of Regeneron’s Board.
Reviewing editors
-
Jonathan Abraham
Harvard Medical School, United States
- Expertise
- Biochemistry and Chemical Biology
- Structural Biology and Molecular Biophysics
- Microbiology and Infectious Disease
- Medicine
- Research focus
- emerging viruses
- antibody neutralisation
- viral entry
- viral replication
- x-ray crystallography
- cryo-EM
-
Cheryl Ackert-Bicknell
University of Colorado, United States
- Expertise
- Medicine
- Genetics and Genomics
- Research focus
- bone biology
- genetics
- musculoskeletal
- aging
-
Anurag Agrawal
CSIR Institute of Genomics and Integrative Biology, India
- Expertise
- Medicine
- Research focus
- asthma
- respiratory diseases
- Experimental organism
- human
- mouse
-
Hossein Ardehali
Northwestern University, United States
- Expertise
- Medicine
- Biochemistry and Chemical Biology
- Research focus
- mitochondria
- iron
- glucose metabolism
- mRNA-binding proteins
- hexokinases
- metabolism
- cardiac biology
-
Annelien Bredenoord
University Medical Centre Utrecht, Netherlands
- Expertise
- Medicine
- Research focus
- medical ethics
- bioethics
- ethics
- genome editing
- technologies
- innovation
- biobanking
- stem cells
- big data
- DNA sequencing
-
Xuetao Cao
Zhejiang University School of Medicine, China
- Expertise
- Cancer Biology
- Immunology and Inflammation
- Medicine
- Research focus
- immunology of APCs
- TLR signalling and immune regulation
- cancer immunotherapy and gene therapy
-
Jean-Laurent Casanova
The Rockefeller University, United States
- Expertise
- Genetics and Genomics
- Microbiology and Infectious Disease
- Immunology and Inflammation
- Medicine
- Research focus
- human genetics
- immunology
- infectious diseases
- primary immunodeficiency
- inborn errors of immunity
- Experimental organism
- human
-
Howard Y Chang
Stanford University, United States
- Expertise
- Medicine
- Chromosomes and Gene Expression
- Genetics and Genomics
- Research focus
- cancer
- immunotherapy
- RNA
- genomics
- epigenomics
- dermatology
- Experimental organism
- human
- mouse
-
Yali Cong
Peking University Health Science Center, China
- Expertise
- Medicine
- Research focus
- medical ethics
- bioethics
-
Alex R Cook
National University of Singapore, Singapore
- Expertise
- Epidemiology and Global Health
- Microbiology and Infectious Disease
- Medicine
- Research focus
- infectious disease epidemiology
- mathematical modelling
- biostatistics
- health policy
-
Seth J Corey
Cleveland Clinic, United States
- Expertise
- Cancer Biology
- Medicine
- Research focus
- myeloid malignancies
- inherited or acquired bone marrow failure
- neutrophils
- platelets zebrafish
- cancer evolution
- proteostasis
-
Ralph J DeBerardinis
University of Texas Southwestern Medical Center, United States
- Expertise
- Cancer Biology
- Cell Biology
- Medicine
- Research focus
- metabolism
- cancer
- genetics
- medicine
- pediatrics
- genomics
- mitochondria
- Experimental organism
- human
- mouse
-
Anna Mae Diehl
Duke University School of Medicine, United States
- Expertise
- Medicine
- Research focus
- gastroenterology
- hepatology
-
Ana Domingos
University of Oxford, United Kingdom
- Expertise
- Medicine
- Neuroscience
- Research focus
- metabolism
- obesity
- neuroimmunity
- autonomic nervous system
- eating behaviour
- inflammation
-
Noriaki Emoto
Kobe Pharmaceutical University, Japan
- Expertise
- Medicine
- Research focus
- cardiology
- pulmonary hypertension
- endothelin
- pharmacology
- vascular biology
-
Jonathan Flint
University of California, Los Angeles, United States
- Expertise
- Genetics and Genomics
- Medicine
- Research focus
- genetics
- genomics
- psychiatric disorders
-
Gregory G Germino
National Institute of Diabetes and Digestive and Kidney Diseases, United States
- Expertise
- Medicine
- Research focus
- nephrology
- genetic renal disease
- polycystic kidney disease
- ciliopathies
-
Evangelos J Giamarellos-Bourboulis
Attikon University Hospital, Greece
- Expertise
- Immunology and Inflammation
- Microbiology and Infectious Disease
- Genetics and Genomics
- Medicine
- Research focus
- sepsis
- hidradenitis suppurativa
- pathogenesis of infection
- biomarkers
-
David Ginsburg
University of Michigan, United States
- Expertise
- Medicine
- Genetics and Genomics
- Research focus
- hemostasis
- thrombosis
- human genetics
- mouse genetics
- endothelial cells
- cargo receptor
- secretion
- Experimental organism
- human
- mouse
- zebrafish
-
Joseph G Gleeson
The Rockefeller University, United States
- Expertise
- Medicine
- Neuroscience
- Developmental Biology
- Research focus
- neurodevelopmental disease
- brain development
- neurogenetics
- autism
- epilepsy
- intellectual disability
- organoid
- stem cells
- genomics
- bioinformatics
- Experimental organism
- human
- mouse
-
Michael R Green
University of Massachusetts Medical School, United States
- Expertise
- Cancer Biology
- Chromosomes and Gene Expression
- Medicine
- Research focus
- transcription
- pre-mRNA splicing
- cancer molecular biology
- oncology
- genetics
- functional genomics
- Experimental organism
- human
- mouse
- S. cerevisiae
-
Timothy D Griffiths
Newcastle University, United Kingdom
- Expertise
- Neuroscience
- Medicine
- Research focus
- auditory
- cognition
- neurology
- imaging
- Experimental organism
- human
- macaque
-
William C Hahn
Dana-Farber Cancer Institute, United States
- Expertise
- Cancer Biology
- Genetics and Genomics
- Medicine
- Research focus
- cancer
- transformation
- functional genomics
- RAS
- YAP1
- Experimental organism
- human
-
Matthew G. Vander Heiden
Massachusetts Institute of Technology, United States
- Expertise
- Cancer Biology
- Medicine
- Research focus
- cancer biology
- biochemistry
- metabolism
- tumor microenvironment
- redox biology
- Experimental organism
- mouse
- human
-
Christopher L-H Huang
University of Cambridge, United Kingdom
- Expertise
- Medicine
- Research focus
- cardiac arrhythmias
- atrial fibrillation
- skeletal muscle
- electrophysiology
- ion channels
- action potential propagation
- genetically modified mice
- patch clamping
- Experimental organism
- mouse
-
Edward D Janus
University of Melbourne, Australia
- Expertise
- Epidemiology and Global Health
- Medicine
- Research focus
- cardiovascular disease
- diabetes
- prevention
- chronic diseases
- clinical guidelines
-
Prabhat Jha
Saint Michael's Hospital, Canada
- Expertise
- Epidemiology and Global Health
- Microbiology and Infectious Disease
- Medicine
- Research focus
- epidemiology
- global health
- infectious disease and population dynamics
- randomized controlled trials
-
Simon C Johnson
Seattle Children's Research Institute, United States
- Expertise
- Cell Biology
- Medicine
- Developmental Biology
- Neuroscience
- Research focus
- mitochondria
- neurodegenerative disease
- aging
- pediatric disease
- genetic disease
- mTOR
- cell culture
- Experimental organism
- mouse
- C. elegans
-
Eunjoon Kim
Korea Advanced Institute of Science and Technology, South Korea
- Expertise
- Medicine
- Neuroscience
- Research focus
- synapse adhesion and synapse development
- synaptic transmission and plasticity
- neurodevelopmental and neuropsychiatric disorders
- autism spectrum disorders
- intellectual disability
- Experimental organism
- mouse
- rat
-
Melanie Königshoff
University of Colorado, United States
- Expertise
- Stem Cells and Regenerative Medicine
- Medicine
- Cell Biology
- Research focus
- lung regeneration
- wnt signaling
- pulmonary fibrosis
- chronic obstructive pulmonary disease
- epithelial cell biology
- Experimental organism
- human
- mouse
-
Dan Larhammar
Uppsala University, Sweden
- Expertise
- Medicine
- Evolutionary Biology
- Neuroscience
- Research focus
- evolution
- gene/genome duplications
- cellular and molecular neuroscience
- G protein-coupled receptors (GPCR)
- neuropeptides
- endocrine peptides
- hypothalamus
- phototransduction
- ligand-gated ion channels
- Experimental organism
- human
- zebrafish
-
Marc Lipsitch
Harvard T.H. Chan School of Public Health, United States
- Expertise
- Epidemiology and Global Health
- Microbiology and Infectious Disease
- Medicine
- Research focus
- pathogen transmission modeling
- evolution of pathogens
- vaccine epidemiology
- antimicrobial resistance
- research ethics
- Experimental organism
- S. pneumoniae
-
Ruth Loos
The Icahn School of Medicine at Mount Sinai, United States
- Expertise
- Epidemiology and Global Health
- Medicine
- Genetics and Genomics
- Research focus
- genetic epidemiology
- obesity
- prediction
- gene discovery
- precision medicine
- Experimental organism
- human
-
Andrew MacPherson
University of Bern, Switzerland
- Expertise
- Immunology and Inflammation
- Medicine
- Research focus
- mucosal immunity
- function of IgA
- mechanisms of host-microbial mutualism
-
Arduino A Mangoni
Flinders Medical Centre, Australia
- Expertise
- Medicine
- Research focus
- clinical pharmacology
- drug safety in old age
- drug repurposing
- drug discovery
- metabolomics
- biomarkers
- cardiovascular pharmacology
- patient-centred outcomes
-
Grant McArthur
Peter MacCallum Cancer Centre, Australia
- Expertise
- Cancer Biology
- Medicine
- Research focus
- melanoma
-
Jean-Pierre Michel
University of Geneva, Switzerland
- Expertise
- Medicine
- Research focus
- aging
- geriatric medicine
- public health
- nutrition
- vaccines
-
Subburaman Mohan
Loma Linda University, United States
- Expertise
- Medicine
- Genetics and Genomics
- Research focus
- bone biology
- endochondral bone formation
- insulin-like growth factors
- osteoporosis
- osteoarthritis
- skeletal development
- Experimental organism
- human
-
Zsolt Molnár
CytoSorbents Europe GmbH, Germany
University of Pécs, Hungary- Expertise
- Medicine
- Research focus
- sepsis
- septic shock
- hemodynamic monitoring
- fluid therapy
- extracorporeal cytokine removal
-
Belinda Nicolau
McGill University, Canada
- Expertise
- Epidemiology and Global Health
- Medicine
- Research focus
- cancer epidemiology
- social determinants of health
-
Ole Haagen Nielsen
Herlev Hospital, University of Copenhagen, Denmark
- Expertise
- Medicine
- Research focus
- gastroenterology (especially inflammatory bowel disease)
- hepatology
- internal medicine
-
Renata Pasqualini
Rutgers University, United States
- Expertise
- Medicine
- Cancer Biology
- Research focus
- radiation oncology
- translational cancer research
- prostate cancer
-
Serge Przedborski
Columbia University Medical Center, United States
- Expertise
- Neuroscience
- Medicine
- Research focus
- Parkinson's disease
- neurodegeneration
- mitochondrial damage
- motor neuron disease
- amyotrophic lateral sclerosis
- astrocytes
- autophagy
- mitophagy
- necroptosis
- apoptosis
- Experimental organism
- human
-
Louis Ptacek
University of California, San Francisco, United States
- Expertise
- Neuroscience
- Medicine
- Research focus
- neurogenetics
- circadian rhythms
- sleep
- episodic disorders
- Experimental organism
- human
- mouse
-
Peter Ratcliffe
University of Oxford, United Kingdom
- Expertise
- Cell Biology
- Medicine
- Research focus
- hypoxia
- signaling
- hypoxia inducible factor
- prolyl hydroxylase
- oxygenase
- cysteine dioxygenase
- von Hippel-Landau
- N-degron
-
Isabel Rodriguez-Barraquer
University of California, San Francisco, United States
- Expertise
- Epidemiology and Global Health
- Microbiology and Infectious Disease
- Medicine
- Research focus
- dengue
- malaria
- Zika
- vector-bone diseases
- serology
- modeling
- Experimental organism
- human
-
Antony Rosen
Johns Hopkins University School of Medicine, United States
- Expertise
- Medicine
- Research focus
- autoimmunity
- autoimmune disease
- rheumatic
- autoantibodies
- granzyme
-
Charles Sawyers
Memorial Sloan-Kettering Cancer Center, United States
- Expertise
- Cancer Biology
- Medicine
- Research focus
- translational medicine
- oncology
- Experimental organism
- human
-
Joshua T Schiffer
Fred Hutchinson Cancer Research Center, United States
- Expertise
- Microbiology and Infectious Disease
- Epidemiology and Global Health
- Immunology and Inflammation
- Medicine
- Research focus
- HSV-2
- herpesviruses
- mucosa
- T cells
- viral shedding
- mathematical modelling
- Experimental organism
- human
- viruses
-
Nima Sharifi
Cleveland Clinic, United States
- Expertise
- Biochemistry and Chemical Biology
- Cancer Biology
- Medicine
- Research focus
- steroid biochemistry
- steroid metabolism
- prostate cancer
- nuclear receptors
- hormone therapy resistance
- androgens
- oncology
- Experimental organism
- mouse
-
Dolores Shoback
University of California, San Francisco, United States
- Expertise
- Medicine
- Research focus
- endocrinology
- metabolism
- metabolic bone disease
- calcium sensing receptor
- parathyroid hormone
- Experimental organism
- human
-
Viviana Simon
The Icahn School of Medicine at Mount Sinai, United States
- Expertise
- Epidemiology and Global Health
- Microbiology and Infectious Disease
- Medicine
- Research focus
- viral-host interactions
- retroviral restriction factors
- HIV drug resistance
-
Lois Smith
Harvard Medical School, United States
- Expertise
- Developmental Biology
- Medicine
- Neuroscience
- Research focus
- age-related macular degeneration
- diabetic eye disease
- retinopathy
- ocular disease
- Experimental organism
- mouse
-
Margaret Stanley
University of Cambridge, United Kingdom
- Expertise
- Cancer Biology
- Microbiology and Infectious Disease
- Medicine
- Epidemiology and Global Health
- Research focus
- vaccines
- cervix cancer
- cervix precancer
- keratinocyte biology
- human papillomavirus
- DNA viruses
- vaccine immunology
- Experimental organism
- human
-
Kiyoshi Takeda
Osaka University, Japan
- Expertise
- Immunology and Inflammation
- Medicine
- Research focus
- mucosal immunology
- inflammatory bowel disease
- intestinal immunity
- intestinal environmental factors
- intestinal epithelial cells
-
Rudolph E Tanzi
Harvard University, United States
- Expertise
- Neuroscience
- Genetics and Genomics
- Medicine
- Research focus
- Alzheimer's disease
- genetics
- neurodegenerative disease
- amyloid
- neuroinflammation
- Experimental organism
- mouse
- human
- brain organoids
-
J Paul Taylor
St. Jude Children's Research Hospital, United States
- Expertise
- Neuroscience
- Cell Biology
- Medicine
- Research focus
- liquid-liquid phase separation
- RNA granules
- biomolecular condensates
- neurodegeneration
- Experimental organism
- D. melanogaster
- human
-
M Dawn Teare
Newcastle University, United Kingdom
- Expertise
- Computational and Systems Biology
- Epidemiology and Global Health
- Medicine
- Research focus
- statistics
- population genetics
- epidemiology
-
Peter Tontonoz
University of California, Los Angeles, United States
- Expertise
- Cell Biology
- Medicine
- Research focus
- lipid metabolism
- cholesterol
- nuclear receptors
- adipocytes
- obesity
- atherosclerosis
- diabetes
- Experimental organism
- mouse
-
Frank van de Veerdonk
Radboud University Medical Center, Netherlands
- Expertise
- Immunology and Inflammation
- Microbiology and Infectious Disease
- Medicine
- Research focus
- medical mycology
- clinical immunology
-
Jacco Wallinga
National Institute for Public Health and the Environment, Netherlands
Leiden University Medical Center, Netherlands- Expertise
- Microbiology and Infectious Disease
- Epidemiology and Global Health
- Medicine
- Research focus
- modeling of infectious diseases
- vaccination
- infectious disease control
- public health
- bioinformatics
-
Hao Zhu
University of Texas Southwestern Medical Center, United States
- Expertise
- Cancer Biology
- Stem Cells and Regenerative Medicine
- Medicine
- Research focus
- mechanisms of tissue repair and organ regeneration
- liver cancer
- hepatocellular carcinoma
- epigenetics
- polyploidy
- Experimental organism
- human
- mouse
-
Wilbert Zwart
Netherlands Cancer Institute, Netherlands
- Expertise
- Cancer Biology
- Medicine
- Research focus
- breast cancer
- prostate cancer
- hormonal regulation
- epigenetics
- transcription factors
- genomic profiling
- Experimental organism
- human
