Editors for Medicine

We aim to review translational research and clinical studies focused on improving human health. Our interests include, but are not limited to, the etiology, pathophysiology, diagnosis, genetics, prevention, and treatment of human disorders, as well as the biological, environmental and socioeconomic determinants of health which lead to changes in medical practice, population health and health policy. Read the latest research in this subject area.

Type

All sections

Senior editors

Ricardo Azziz

University at Albany, SUNY, United States
University of Alabama at Birmingham, United States

Ricardo Azziz, MD, MPH, MBA is an educator-scientist-executive with over 25 years of leadership experience in higher education, research, and academic health, who serves as Chief Science & Strategy Officer, and EVP for Operations, Strategy, and Scientific Affairs at The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. He served as Chief Officer of Academic Health & Hospital Affairs of the State University of New York (SUNY) System Administration, as founding President of Georgia Regents University (now Augusta University), as founding CEO of the Georgia Regents Health System (now Augusta University Health System), and as president of the Georgia Health Sciences University. He also served as Deputy Director of the Clinical & Translational Sciences Institute and as Assistant Dean for Clinical and Translational Sciences at UCLA, as Director of the Center for Androgen-Related Disorders at Cedars-Sinai Medical Center in Los Angeles, and as founder and Executive Director/Senior Executive Director of the Androgen Excess & PCOS Society.

Among other national and international advisory capacities, he has served on multiple NIH committees, chaired the U.S. FDA Advisory Board on Reproductive Health Drugs, and served on the oversight committee for the California Institute for Regenerative Medicine. He has received, among other recognitions, the 2000 President's Achievement Award of the Society for Gynecologic Investigation; elected member of the Association of American Physicians; and is recipient of the 2014 Alumni Fellow Award of the Pennsylvania State University Alumni Association.

He serves on the faculties of the School of Public Health, University at Albany, SUNY and the Schools of Medicine and Public Health, University of Alabama at Birmingham.

Expertise
Medicine

Research focus
reproductive health
reproductive biology
reproductive endocrinology
gynecology
ob-gyn
women's health
polycystic ovary syndrome (PCOS)
hirsutism
androgen excess
adrenal hyperplasia
health policy
public health
social determinants of health
healthcare organization

Experimental organism
human

Competing interests statement
Ricardo Azziz is a consultant for Spruce Biosciences and Fortress Biotech, and holds stocks at Martin Imaging.
Matthias Barton

University of Zurich, Switzerland

Matthias Barton, MD, is a Professor of Cardiology at the University of Zurich. His clinical and investigative focus are general cardiology and preventive medicine, with a particular interest in coronary artery disease and myocardial infarction. His work explores mechanisms of atherosclerosis, heart disease in women, and vascular factors contributing to cardiovascular health and disease.

Expertise
Medicine

Research focus
cardiovascular medicine
coronary artery disease
vascular biology
heart disease in women
molecular medicine

Competing interests statement
Matthias Barton has received funding from the Swiss National Science Foundation and is on the editorial boards of the American Journal of Cardiovascular Disease, the American Journal of Physiology Regulatory Integrative & Comparative Physiology, Endocrine and Metabolic Science, Experimental Biology and Medicine, Arteriosclerosis, Thrombosis and Vascular Biology and Hypertension, official journals of the American Heart Association. He has been an elected ordinary member of the Academy of Europe (Academia Europaea) since 2017.
Balram Bhargava

Indian Council of Medical Research, India

Dr Bhargava is the Director General of the Indian Council of Medical Research (ICMR) Secretary, Department of Health Research, (Ministry of Health & Family Welfare), Government of India.

Professor (Dr) Balram Bhargava was born in Lucknow 21st July 1961. He received all his medical training at the King George Medical College, Lucknow. Further, he received advanced training at the Gardiner Institute, University of Glasgow and the Washington Heart Centre, Washington DC.

Balram Bhargava is Professor of Cardiology at the All India Institute of Medical Sciences, New Delhi, and also serves as the Executive Director for Stanford India Biodesign Centre, School of International Biodesign (SiB).

He is a cardiologist at the forefront of biomedical innovation, public health, medical education, and medical research. He directs the School of International Biodesign at AIIMS, an interdisciplinary programme to foster innovation and design of low-cost implants and devices which has led to more than thirty patents on low-cost medical devices and a dozen start-ups. He developed the indigenous Platinum Iridium coil coronary stent and has been instrumental in clinically evaluating and establishing medicated Indian stents. He has led innovations initiatives, such as Society for Less Investigative Medicine (SLIM). He is currently providing leadership for creative disease prevention, early detection, and transport system for sick cardiac patients (mission DELHI (Delhi Emergency Life Heart-Attack Initiative) by trained motorcycle first responder Paramedics).

Professor Bhargava was awarded the Padma Shri by the Indian government for his contributions to medicine. He is also been awarded the SN Bose Centenary Award by the Indian National Science Congress, the National Academy of Sciences Platinum Jubilee Award, the Tata Innovation Fellowship, Vasvik Award for Biomedical Technology Innovation, the Ranbaxy Award, OP Bhasin Award in the field of Health and Medical Sciences and more recently the UNESCO Equatorial Guinea Prize for Life Sciences. Dr Lee Jong-Wook Memorial Prize for Public Health, 2019 by WHO Hqrs, Geneva and received President’s Medal Award from Royal College of Physicians and Surgeons of Glasgow, UK for his research in ‘Frugal Innovations’ in February 2020.

Expertise
Medicine
Epidemiology and Global Health

Research focus
interventional cardiology
stents
restenosis
coronary artery disease
risk factors of valvular heart disease
interventions of rheumatic heart disease
epidemiology
non-communicable disease
infectious disease
health policy
public health

Experimental organism
human

Competing interests statement
Dr Bhargava is the founding editor of the British Medical Journal Innovations (BMJi) until 2018, and he is currently the Editor-in-Chief of the Indian Journal of Medical Research.
Christian Büchel

University Medical Center Hamburg-Eppendorf, Germany

Christian Büchel is a member of the Hamburg Center for Neuroscience in Hamburg, where he is also the Director of the Department for Systems Neuroscience at Hamburg University Medical Center. He holds an Affiliate Professor appointment in the Psychology department at the University of Hamburg. After Medical School at the University of Heidelberg, he performed postdoctoral research with Karl Friston as a Wellcome Research Fellow at the Wellcome Department of Imaging Neuroscience at UCL in London with a focus on effective connectivity.

Establishing his lab in Hamburg, he focused on the cognitive neuroscience of pain and motivation and initially studied decision making with an emphasis on delay discounting. In a parallel stream of projects he observed that the pain modulation underlying placebo analgesia can already be observed at the spinal cord level, a finding which he later also established for nocebo hyperalgesia. He is part of the IMAGEN study and during his time at Stanford he identified hypoactivation of reward circuits as a potential risk factor for addiction.

He is a member of the Academy of Science in Hamburg and was awarded the Jung Award for Medicine, the Gottfried Wilhelm Leibniz-Preis by the German Research Foundation, and the Wiley Young Investigator Award of the Organization for Human Brain Mapping for recognition of his work in cognitive neuroscience.

Expertise
Neuroscience
Medicine

Research focus
cognitive neuroscience
pain modulation
decision-making
fear
anxiety
addiction

Experimental organism
human

Competing interests statement
Christian Büchel has received research grants from the European Research Council, Deutsche Forschungsgemeinschaft and Bundesministerium für Bildung und Forschung. He serves on the board of reviewing editors of Science magazine. He serves on the Swiss National Research Council, the Scientific Advisory Board of the ICM in Paris and the Center for Behavioral Brain Sciences, Magdeburg, Germany.
Nancy Carrasco

Vanderbilt University School of Medicine, United States

Nancy Carrasco is the Joe C. Davis Professor and Chair of the Department of Molecular Physiology and Biophysics at the Vanderbilt University School of Medicine. She obtained her MD and Master’s in Biochemistry from the National Autonomous University of Mexico in her native Mexico City. Dr Carrasco did her postdoctoral work at the Roche Institute of Molecular Biology in New Jersey, for which she received a Fogarty International Fellowship. She then joined the Department of Molecular Pharmacology at the Albert Einstein College of Medicine, and later the Department of Cellular and Molecular Physiology at the Yale School of Medicine. Dr Carrasco has a longstanding interest in transport across biological membranes and in the role of membrane proteins in physiology and pathophysiology. Her cloning of the sodium/iodide symporter (NIS) has had numerous ramifications for many other fields, including structure/function of transport proteins, molecular endocrinology, gene transfer studies, cancer, and public health (she has served on the EPA’s Science Advisory Board). She has received numerous awards, including the Pew Award; the Arnold and Mabel Beckman Foundation Award; the Maria Sibylla Merian Award (Germany); the Merck Prize from the European Thyroid Association (Poland); the Rose Pitt-Rivers Lectureship at the British Endocrine Society Meeting (Scotland); the Noun Shavit Award (Israel); the Marshall S. Horwitz Faculty Prize for Research Excellence; and the Light of Life Award. She has served as president of the Society of Latin American Biophysicists. Dr Carrasco was elected to the National Academy of Sciences in 2015 and to the National Academy of Medicine in 2020.

Expertise
Medicine
Biochemistry and Chemical Biology
Structural Biology and Molecular Biophysics

Research focus
molecular endocrinology
biochemistry of membrane proteins
biophysics of membrane proteins
mechanistic information of NIS
regulation of NIS
sodium/iodide symporter
cross-talk between hormones
metabolism

Experimental organism
mouse
human

Competing interests statement
Dr Carrasco’s research has been funded by NIH. She is on the NICHD Board of Scientific Counselors.
Arturo Casadevall

Johns Hopkins Bloomberg School of Public Health, United States

Arturo Casadevall, MD, PhD is a Bloomberg Distinguished Professor and Chair of the W Harry Feinstone Department of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health. He obtained his BA in Chemistry at Queens College of the City University of New York. Previously, he served as Director of the Division of Infectious Diseases at Montefiore Medical Center, the University Hospital and Academic Medical Center for Einstein, from 2000–2006 and as Chair of the Department of Microbiology and Immunology from 2006–2014.

Dr Casadevall received both his MD and PhD (biochemistry) degrees from New York University. Subsequently, he completed his internship and residency in internal medicine at Bellevue Hospital in New York. He then completed subspecialty training in infectious diseases at Montefiore and Einstein. The author of over 700 scientific papers, numerous books and book chapters, Dr Casadevall’s major research interests are in fungal pathogenesis and the mechanisms of antibody action. In the area of biodefense, he has an active research program to understand the mechanisms of antibody–mediated neutralization of Bacillus anthracis toxins.

In recent years, Dr Casadevall has become interested in problems with the scientific enterprise and with his collaborators shown that misconduct accounts for the majority of retracted publications. He has suggested a variety of reforms to the way science is done. Dr Casadevall is the editor–in–chief of mBio, the first open access general journal of the American Society of Microbiology, and is on the editorial board of several journals including the Journal of Infectious Diseases and the Cell Surface.

He has also served in numerous NIH committees including those that drafted the NIAID Strategic Plan and the Blue Ribbon Panel on Biodefense Research. He served on the National Academy of Sciences panel that reviewed the science on the FBI investigation of the anthrax terror attacks of 2001 and has served on the NAS Committee of Federal Regulations and Reporting requirements. He has also served as a member of the National Science Advisory Board for Biosecurity from 2005–2014. In 2008, he was recognized by the American Society of Microbiology with the William Hinton Award for mentoring scientists from underrepresented groups. In 2015, Dr Casadevall was appointed a Commissioner to the National Commission on Forensic Science, the United States Department of Justice. He has served as President of the Medical Mycology Society of America, Chair of American Society for Microbiology Division F, Chair of the American Society for Microbiology Career Development Committee, Co–Chair of the National Institute of Allergy and Infectious Diseases Board of Scientific Counselors, and currently serves on the Scientific Council/Advisory Board for the Pasteur Institut and VIB Research Institute in Belgium. He is a member of the American Society for Clinical Investigation, American College of Physicians and the Association of American Physicians, and was elected Fellow of the American Association for the Advancement of Science and the American Academy of Microbiology. In 2014, he became an elected member of the National Academy of Medicine and in 2017, he was elected to the American Academy of Arts and Sciences.

Expertise
Immunology and Inflammation
Medicine
Microbiology and Infectious Disease

Research focus
molecular microbiology and immunology
pathogenic microbes
cryptococcosis
anthrax
mycobacterium tuberculosis
vaccines

Experimental organism
Cryptococcus neoformans
Bacillus anthracis

Competing interests statement
Arturo Casadevall is Editor in Chief of mBio (until 2025), and serves on the editorial boards of Journal of Experimental Medicine, Journal of Clinical Investigation, and Journal of Infectious Diseases.
Murim Choi

Seoul National University College of Medicine, South Korea

Murim Choi’s main scientific question is to elucidate the genetic mechanisms of human diseases. To address this, his expertise lies in the functional interpretation of human genetic variants using genomic and bioinformatic methodologies. He graduated from Seoul National University (SNU), Seoul, Korea, majoring in Molecular Biology (BS and MS). During the Ph.D course at Duke University, he studied cardiovascular system development in mice. In his postdoctoral training at Yale University, he studied human genetics, setting up a whole exome sequencing pipeline and applying it to various human diseases to identify causal genes. He received a K99/R00 grant for the postdoctoral works and was a recipient of SNU Invitation Program for Distinguished Scholar grant.

Establishing his independent lab at SNU, he has been studying the genetic mechanisms of rare disease pathogenesis, focusing on cases with neurodevelopmental defects. His current approach combines developmental biology and genetics, shaped by the fact that most pediatric rare disease patients experience congenital problems. More recently, his group has undertaken common disease research. His group recently established a bioinformatic pipeline that allows screening of eQTL signals only functioning in the non-alcoholic fatty liver disease (NAFLD) status and validated its utility. At SNU, he has been instrumental in establishing genetics and genomics methodologies by collaborating with clinicians in SNU Hospital. His lab has recently established protocols in advanced functional genomics approaches, including single-cell sequencing, saturation mutagenesis, modifier screening, and cell tracing technique to understand the genetic mechanisms underlying disease progression.

He has a strong interest in clinical and translational research, especially in elucidating genotype-phenotype relationships that may lead to human diseases. In 2018, he was selected as a member of the Young Korean Academy of Science and Technology.

Expertise
Genetics and Genomics
Medicine

Research focus
rare diseases
neurodevelopmental disorders
functional characterization of genetic variants
bioinformatics
Mendelian genetics

Competing interests statement
Current funding: Genetic elucidation of rare developmental disorders (200M KRW/year (~152,800 USD); Apr. 2014-Sep.2022; National Research Foundation of Ministry of Science and ICT); Genetic elucidation of gene expression noises (300M KRW/year (~229,200 USD); Mar. 2021-Feb. 2025; National Research Foundation of Ministry of Science and ICT); Discovery of NAFLD causing genes using single cell expression quantitative trait loci approach (80M KRW/year (~61,120 USD); Apr. 2021-Dec. 2025; National Research Foundation of Ministry of Science and ICT).Other editorial roles: editor of Experimental and Molecular Medicine (Springer Nature)
Miles P Davenport

University of New South Wales, Australia

Miles Davenport is Professor of Medicine and Head of the Infection Analytics Program at the Kirby Institute for Infection and Immunity at UNSW Sydney. He graduated in medicine from the University of Sydney and completed his DPhil at the University of Oxford in immunology before retraining in mathematical biology. He leads a team of applied mathematicians who use statistical analysis and modelling to understand host-pathogen interactions in infection and immunity. This involves collaboration with a wide variety of experimental and clinical scientists both in Australian and internationally. Major areas of investigation include understanding HIV latency, malaria immunity and treatment, and neonatal immune development. He is a past-President of the Australasian Society for Immunology and is supported by an NHMRC (Australia) Investigator grant.

Expertise
Immunology and Inflammation
Microbiology and Infectious Disease
Epidemiology and Global Health
Medicine

Research focus
virology
immunity
vaccines
HIV/AIDS
mathematical modelling
host-pathogen interactions
biostatistics

Competing interests statement
Miles Davenport receives funding from the National Health and Medical Research Council (Australia), the Australian Research Council, and the National Institutes of Health (USA). He is an Associate Editor at PLoS Computational Biology and on the Editorial Board of Immunology and Cell Biology.
Betty Diamond

The Feinstein Institute for Medical Research, United States

Betty Diamond received an MD from Harvard Medical School. She performed a residency in Internal Medicine at Columbia Presbyterian Medical Center, and then a post-doctoral fellowship in Immunology with Dr Matthew Scharff at the Albert Einstein College of Medicine. She is currently Director of the Institute of Molecular Medicine at the Feinstein Institute for Medical Research.

Dr Diamond’s research has focused on the induction and pathogenicity of anti-DNA antibodies in Systemic Lupus Erythematosus. She showed that somatic mutation of immunoglobulin genes can generate autoantibodies in mice and humans, making the germinal center a focus in disease pathogenesis. Her laboratory has also demonstrated that a subset of anti-DNA antibodies cross-reacts with the NMDA receptor and showed that autoantibodies can cause aspects of neuropsychiatric lupus, creating a paradigm for antibody-mediated changes in brain function in many conditions. Most recently, she has developed a research program on the immunomodulatory functions of C1q.

She received the Outstanding Investigator Award of the ACR in 2001, the Lee Howley Award from the Arthritis Foundation in 2002, and the Recognition Award from the National Association of MD-PhD Programs in 2004 and the AAI Distinguished Fellow Award in 2019. In 2006, she was elected to the Institute of Medicine and became a fellow of the AAAS. She has served on the Scientific Council of NIAMS and the Board of Directors of the American College of Rheumatology. She is a past President of the American Association of Immunologists.

Expertise
Medicine
Immunology and Inflammation

Research focus
B cells
systemic lupus
neuropsychiatric lupus
autoantibodies
autoimmunity

Experimental organism
human
mouse

Competing interests statement
Betty Diamond receives funding from the NIH, LuCIN (Lupus Clinical Investigators Network), Lupus Research Alliance, DOD Lupus and Leidos Biomedical Research, Inc.. She is the Chief Editor at Molecular Medicine and a Deputy Editor for Frontiers in Immunology.
Wafik S El-Deiry

Brown University, United States

Wafik El-Deiry, MD, PhD, FACP is Associate Dean for Oncologic Sciences at the Warren Alpert Medical School, Director, Cancer Center at Brown University, and Director of the Joint Program in Cancer Biology at Brown and Lifespan. He is a Professor of Pathology and Laboratory Medicine, Professor of Medical Science, and Mencoff Family University Professor at Brown. He sees patients in his weekly clinic at Rhode Island Hospital focused on care of patients with colorectal cancer and participates in clinical trials based on his laboratory’s research on novel therapeutics. He previously served as Deputy Director for Translational Research, co-Leader of the Molecular Therapeutics Program, Professor of Oncology, and the William Wikoff Smith Endowed Chair in Cancer Research at Fox Chase Cancer Center. From 2010 through 2014 Dr El-Deiry was the Rose Dunlap Professor of Medicine and Chief of Hematology-Oncology at Penn State. In 2009, El-Deiry became an American Cancer Society Research Professor. He was previously a tenured Professor of Medicine (Hematology-Oncology), Genetics, and Pharmacology at University of Pennsylvania, co-Leader of the Radiobiology and Imaging Program at the Abramson Cancer Center and Associate Director for Physician-Scientist Training in Hematology-Oncology when he left Penn in 2010. He earned MD/PhD degrees from University of Miami School of Medicine and completed internal medicine residency and medical oncology fellowship at the Johns Hopkins Hospital and the Johns Hopkins Oncology Center. As a practicing academic Oncologist, his scientific interest and expertise is in cell death, drug resistance in cancer and drug discovery and development. El-Deiry founded two companies, Oncoceutics, Inc. and p53-Therapeutics, Inc.

El-Deiry discovered p21(WAF1) as a p53 target gene, universal cell cycle inhibitor, and tumor suppressor gene that for the first time explained the mammalian cell stress response. He discovered TRAIL receptor DR5 and its regulation by p53. TRAIL is part of the host immune system that suppresses cancer and its metastases. His lab created a knock-out mouse for TRAIL receptor DR5 and this mouse is tumor prone and develops an inflammatory syndrome in the lungs and gut after sub-lethal irradiation. He identified c-Myc as a major determinant of TRAIL sensitivity and demonstrated synergy between TRAIL therapy and multi-kinase inhibitor sorafenib. Building on his prior accomplishments, El-Deiry discovered ONC201/TIC10 as a first-in-class TRAIL pathway inducer that is orally bioavailable and crosses the blood-brain barrier to treat brain tumors. TRAIL and Foxo3a are required for the anti-tumor effect of ONC201 through dual blockade of ERK and Akt kinases that promotes the nuclear translocation of the Foxo3a transcription factor which directly regulates the TRAIL gene. Data from El-Deiry’s lab identified that ONC201 induces TRAIL receptor DR5 through an integrated stress response involving ATF4 and CHOP transcription factors. Patients with among the most aggressive gliomas (H3K27M mutant DIPG) have had exceptional responses to ONC201.

As a physician-scientist, Dr El-Deiry has worked to bring new discoveries to the clinic. He is committed in the next phase of his career to unraveling the mechanisms involved in p53 pathway restoration by candidate therapeutics his lab has discovered. This is exciting as he is defining a novel class of anti-cancer drugs with p53 pathway restoration and S-phase checkpoint targeting and recognizing ATF4 as a major transcription factor mechanism for p53 pathway restoration in p53-null or p53 mutant tumor cells. He is establishing transcriptomic and proteomic data sets with chemotherapy that acts through p53, and with novel small molecules that restore the p53 pathway in p53-deficient or mutant p53 expressing cells. He is exploiting medicinal chemistry and organoid technologies to perform his translational science that is leading to clinical trials some of which he leads. Dr El-Deiry conducts basic and translational clinical oncology therapeutics research through funded NIH grants, Foundations and industry. He is a member of the ASCI, AAP, Past President of the Interurban Clinical Club, previous Chair of ASCO’s Tumor Biology Track, and past Chair of an NIH Study Section on Cancer Therapeutics. Dr El-Deiry has trained many students and post-doctoral fellows, physician-scientists, and continues to mentor junior scientists and faculty in basic and translational cancer research.

Expertise
Medicine
Cancer Biology

Research focus
cancer
tumor suppressor genes
colorectal cancer
p53 pathway
cell death
medical oncology
drug development
drug discovery
p21(WAF1)
ONC201/TIC10
physician-scientist issues

Experimental organism
human
mouse

Competing interests statement
Dr El-Deiry receives funding from the NIH/NCI, the Warren Alpert Foundation, and D&D Pharmatech. He is a Specialty Chief Editor for the Cancer Molecular Targets and Therapeutics Section of Frontiers in Oncology. He is also a Section Editor for Molecular Oncology and HemOnc Today. Dr El-Deiry is the scientific founder and shareholder of Oncoceutics, Inc. and p53-Therapeutics, Inc.
Neil Ferguson

Imperial College London, United Kingdom

Neil Ferguson is Head of the Department of Infectious Disease Epidemiology at Imperial College London, where he leads the MRC Centre for Outbreak Analysis and Modelling. His research aims to improve the understanding of epidemiological factors and population processes that shape infectious disease spread in human and animal populations. A practical focus of his work is the analysis and optimisation of intervention strategies that are aimed at reducing transmission or disease burden.

Expertise
Epidemiology and Global Health
Microbiology and Infectious Disease
Medicine

Research focus
epidemiology and infectious disease
emerging infections
mosquito-borne infections
statistical and mathematical tools
Eduardo Franco

McGill University, Canada

Eduardo Franco is Professor and Chairman, Department of Oncology, and Director, Division of Cancer Epidemiology, McGill University, Montreal. He holds BSc (1975) and Licentiate (1976) degrees in biology from Universidade de Campinas, Brazil, and master's (MPH) and doctoral (DrPH) degrees in public health microbiology from the University of North Carolina at Chapel Hill (1981-84). He was a Guest Researcher at the US Centers for Disease Control in Atlanta (1980-81 and 1983-84), and a post-doctoral fellow in cancer epidemiology during 1984 at the International Agency for Research on Cancer in Lyon, France, at the US National Cancer Institute (NCI) in Bethesda, and at Louisiana State University, in New Orleans. Since 1985, he has conducted epidemiologic research on the causes of cancer and on the means to prevent it or to improve patient survival. He is mostly known for his contributions to our understanding of human papillomavirus infection as the cause of cervical cancer and using this knowledge to prevent this cancer via vaccination and improved screening strategies. He received the Canadian Cancer Research Alliance’s Distinguished Service to Cancer Research Award, Lifetime Achievement Awards from the American Society for Colposcopy and Cervical Pathology and from the International Papillomavirus Society, the Women in US Government’s Leadership Award, the Canadian Cancer Society’s Warwick Prize, the Geoffrey Howe Outstanding Contribution Award from the Canadian Society for Epidemiology and Biostatistics, the University of British Columbia’s Chew Wei Memorial Prize in Cancer Research, and the McLaughlin-Gallie Award from the Royal College of Physicians of Canada. He has mentored 115 graduate students and post-doctoral fellows, and 30 undergraduate trainees. He is Officer of the Order of Canada and Fellow of the Royal Society of Canada and of the Canadian Academy of Health Sciences. Heholds an honorary doctorate from Universidade Fernando Pessoa, Porto, Portugal.

Expertise
Cancer Biology
Epidemiology and Global Health
Medicine

Research focus
cancer epidemiology
cancer prevention
human papillomavirus
cancer screening

Experimental organism
human

Competing interests statement
Entire research program funded by the Medical Research Council of Canada (until 1999), Canadian Institutes of Health Research (CIHR) (1999-present), National Institutes of Health, Canadian Cancer Society, and Cancer Research Society. He has received salary awards from the Fonds de Recherche Quebec Santé and CIHR. He holds a James McGill Professorship and the Minda de Gunzburg Endowed Chair at McGill University. He serves as Editor-in-Chief for Preventive Medicine and Preventive Medicine Reports and serves on the editorial boards of Cancer Epidemiology, Biomarkers & Prevention, International Journal of Cancer, Papillomavirus Research, and Salud Publica de Mexico. He has served as occasional consultant to companies involved with HPV vaccination (Merck and GSK) and HPV diagnostics (Roche, Abbott, Qiagen, and BD).
Wendy S Garrett

Harvard T.H. Chan School of Public Health, United States

Wendy Garrett is a Professor of Immunology and Infectious Diseases at the Harvard T. H. Chan School of Public Health, co-Director of the Harvard Chan Center for the Microbiome in Public Health, and an Associate Member of the Broad Institute. Her work explores host-microbiota interactions underlying mucosal immune homeostasis, gastrointestinal inflammatory disorders, and cancer. She graduated from the Yale College; received her MD PhD from Yale University and completed post-graduate training at Harvard.

Expertise
Immunology and Inflammation
Microbiology and Infectious Disease
Medicine

Research focus
host-microbiota interactions
microbiome
mucosal immunology

Competing interests statement
Wendy Garrett serves on advisory boards of Evelo Biosciences, Kintai Therapeutics, and Leap Therapeutics. She is a member of the Cell Reports and Journal of Clinical Microbiology editorial boards.
Diane M Harper

University of Michigan, United States

Diane M Harper, MD, MPH, MS, completed her undergraduate and graduate degrees at the Massachusetts Institute of Technology in Cambridge, Massachusetts, in the fields of Chemical Engineering and Polymerics. She received her medical and public health degrees from the University of Kansas in Kansas City, where she also did residencies in Gynecology/Obstetrics and Family Medicine. Dr Harper has spent the majority of her professional career at Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, as clinician, teacher and researcher in the Departments of Obstetrics and Gynecology, Community and Family Medicine and Women’s and Gender Studies, including improving life for LGBTQ.

She has received the Society of Teachers of Family Medicine (STFM) Excellence in Education Award and the Curtis Hames Research Award honoring her for changing medical care for women through evidence based research. She served as the Chair of Family and Geriatric Medicine at the University of Louisville during which time she also served on the United States Preventive Services Task Force.

She currently is a tenured Professor at the University of Michigan, serving as the Director for Research Management within the Michigan Institute of Clinical and Health Research, one of 50 Clinical and Translational Science Award Research Hubs across the United States. To date she has over 250 peer reviewed publications with over 27,000 citations, and over 40,000 downloads of her seminal review of HPV vaccines.

While at Dartmouth she developed and directed the Gynecologic Cancer Prevention Research Group based at the Norris Cotton Cancer Center in which research on all aspects of HPV associated diseases, specifically cervical cancer prevention was conducted. She is an internationally recognized expert on Human Papillomavirus, the cause of cervical cancer, and its prophylactic and therapeutic vaccines. She has published the seminal clinical research on HPV vaccines and lectured internationally in over 100 countries. She has served on NCI research committees, European research study sections, addressed the Council on Foreign Affairs, and served as a technical advisor to the World Health Organization. Dr Harper has been honored as one of the top clinicians in her field in the US, and Family Physician of the Year in New Hampshire in 2006.

Expertise
Medicine
Epidemiology and Global Health
Microbiology and Infectious Disease
Immunology and Inflammation

Research focus
HPV associated diseases
primary care
women's health
cancer precursor detection
health behaviours
epidemiology
cancer screening

Experimental organism
human

Competing interests statement
Diane Harper has received funding from NCI, NCATS, NHLBI, CDC, multiple national philanthropic organizations, including the American Cancer Society, The Robert Wood Johnson Foundation, and the Susan G Komen Foundation, in addition to state and local funding agencies and collaborations with industry. She serves in editorship capacities on boards including the Annals of Family Medicine, Preventive Medicine Reports, PLoS ONE, and Gynecologic Oncology. She is a peer reviewer for The Lancet, The New England Journal of Medicine, JAMA, among other journals.
Carlos Isales

Medical College of Georgia at Augusta University, United States

Carlos Isales is from San Juan, Puerto Rico, where he graduated from the University of Puerto Rico School of Medicine and did his residency in Internal Medicine at the San Juan Veterans Administration Hospital. He completed a fellowship in Endocrinology and Metabolism at Yale University School of Medicine working in a laboratory under Dr Howard Rasmussen. In 1993, he moved to the Medical College of Georgia in Augusta, GA to help establish the Institute of Molecular Medicine and Genetics. His work has focused on defining the impact of nutrients on bone metabolism and loss of nutrient sensing with aging leading to both bone and muscle loss. His group was among the first to characterize an entero-osseous axis linking incretin hormones and bone turnover. Current work is focused on defining the impact of oxidation of aromatic amino acids and downstream metabolites such as tryptophan-kynurenine on stem cell proliferation and differentiation and resultant age-related osteoporosis. He is currently Chief of the Division of Endocrinology and Metabolism at Augusta University, Regents’ Professor and J. Harold Harrison Distinguished University Chair in Healthy Aging. He is also the Clinical Director of the newly established Center for Healthy Aging. His research is funded by the National Institutes of Aging. He is also passionate about mentoring the next generation of scientists and is MPI on a training award from the National Institutes on Aging.

Expertise
Medicine

Research focus
aging
stem cells
epigenetics
metabolic bone disease
nutrition
amino acid metabolism
tryptophan metabolism

Experimental organism
human
mouse

Competing interests statement
Carlos Isales is currently funded by the National Institute on Aging. He is co-founder of Gerologix, a company focused on developing countermeasures to musculoskeletal aging. He is currently Academic Editor for PLOS ONE and JBMR Plus.
Caigang Liu

Shengjing Hospital of China Medical University, China

Caigang Liu received his PhD from the China Medical University, and trained clinically at first hospital of China Medical University. Then joined and served as a director of Breast Center Shengjing Hospital of China Medical University in 2016. His current research interests focus on clinical and translational research of oncology. In recent years, he has led a clinical research term to explore the improvement in breast reconstruction surgery and highly safe and effective anti-cancer strategies, along with identification of therapeutic targets and development of small molecular drugs against cancer metastasis. He has led several projects funded by the National Natural Science Foundation, including the discovery of FSIP1 as a new target for anti-HER2 treatment, and is developing a new strategy to reverse anti-HER2 resistance in breast cancer. He is a member of the National Micro-noninvasive Committee of Chinese Medical Association, a vice chairman of the first breast disease branch of China Sexology Association, and a member of the Standing Committee in breast cancer marker collaboration group of Chinese Anti-cancer Association.

Expertise
Medicine
Cancer Biology

Research focus
surgical oncology
oncological clinical trials
breast cancer translational medicine
cancer metastasis and drug resistance
small molecular drug development

Experimental organism
human
mouse

Competing interests statement
Caigang Liu is currently funded by the National Natural Science Foundation of China and “Top young talent” project of Liaoning province, China. He now holds a number of patents for anti-tumor small molecular drugs and Traditional Chinese Medicine.
Shlomo Melmed

Cedars-Sinai Medical Center, United States

Shlomo Melmed MD's career has focused on integrating basic science discovery with prospective study of patients with pituitary disease. He has trained more then 70 pre- and post-doctoral trainees. His laboratory is at the forefront of pituitary discovery, focusing on the study of the pathogenesis and treatment of pituitary tumors. Fundamental discovery achievements include elucidating intrapituitary signaling mechanisms underlying excess tumor-derived GH, ACTH or PRL secretion; identification of novel subcellular therapeutic targets for drug application in clinical trials; understanding the relationship between tumor cell proliferation and GH hypersecretion and peripheral GH actions. Dr Melmed and colleagues have applied these findings to understanding cell cycle mechanisms underlying the extraordinarily rare transformation of these invariably benign adenomas to malignancy. They have coupled these translational discoveries with leading scholarly roles in developing clinical guidelines, pivotal investigator-initiated clinical trials, and original disease classification for pituitary medicine.

Expertise
Medicine
Cancer Biology

Research focus
endocrinology
pituitary medicine
endocrine tumors

Competing interests statement
Shlomo Melmed MD edits The Pituitary, and co-edits the Williams Textbook of Endocrinology; he is Editor-in-Chief of Pituitary and post-Editor-in-Chief of Endocrinology. He was President of the Pituitary Society, and of International Society of Endocrinology and is a director of the California Institute of Regenerative Medicine. His laboratory is funded by the NIH.
Tony Ng

King's College London, United Kingdom

Tony Ng (FMEDSCI, MB ChB, MRCP, FRCPath, PhD) brings a rich spectrum of knowledge and capabilities with clinical experience in treating AIDS patients (with opportunistic infections and cancers) and fundamental immunology skills. He is also a pioneer of molecular imaging in cancer. He was the first person to use antibody based fluorescence lifetime imaging (FLIM) approaches in tumour cells and tissues to monitor protein states and function. He has published on how to visualize protein biochemistry in preclinical models; as well as in patient-derived cancer tissues for establishing in vitro/ companion diagnostics. He has adopted a multidisciplinary approach to understand cancer recurrence and also to stratify molecularly targeted agents in combination with immunotherapy. His research bridges the gap between physics, biology and medicine, particularly in the field of translational cancer research.

For clinical translation, he has the proven ability to coordinate and work cooperatively with colleagues and leaders in a wide variety of disciplines (imaging, cell biology, oncology, bioinformatics, surgery, pathology, genomics, as well as physical science disciplines such as mathematics, physics, chemistry and engineering). He has directed the KCL and UCL Comprehensive Cancer Imaging Centre (CCIC, one of four centres funded by CRUK & EPSRC in the UK) since its inception in 2008. The vision for the CCIC is to develop novel imaging (PET and MRI) technologies and use them in combination with clinicopathological assessment, genomics and in-house nanoscopic imaging to measure protein interactions in the context of interventional trials. In such trial context, the tissue imaging (FLIM histology) approach he has developed and refined over the years is beginning to reveal ErbB/ HER receptor rewiring as a mechanism of resistance in human tumours under selection pressure such as cetuximab.

Tony Ng is the current Director of the Comprehensive Cancer Centre, part of the KCL School of Cancer & Pharmaceutical Sciences, and the National Institute for Health and Care Research (NIHR) Guy’s & St Thomas’ Biomedical Research Centre (BRC) Cancer Theme. In 2022, he joined GSK on a part-time basis, to help establish the GSK-KCL Translational Oncology Research Hub which was which was announced in September 2021. The aim is to apply his clinical medicine training as well as immunology, biochemistry and imaging expertise to accelerate the development of the anti-cancer drugs. HIs experience of collaborating with mathematicians/theoretical physicists creates an opportunity to bridge the biology & AI/ML interface, an essential component of delivering the innovative Digital biological twin vision.

Training/expertise: Medicine, Immunology, Cancer cell biology, Biochemistry and Optical Imaging/Biophysics as well as preclinical Radionuclide imaging.

Expertise
Medicine
Cancer Biology
Immunology and Inflammation

Research focus
imaging
biomarkers
trial
immune
cancer
reverse translation
exosome
organoid
tumour microenvironment

Competing interests statement
At KCL, Tony Ng receives funding from Cancer Research UK, Medical Research Council, Wellcome Leap Inc., European Commission and GSK. He is employed on a part time basis as the Vice President of the Digital biological twin Unit at GSK.
Paul W Noble

Cedars-Sinai Medical Centre, United States

Paul W Noble, MD is a physician-scientist at the Cedars-Sinai Medical Center in Los Angeles where he is a Professor of Medicine and Chair of the Department of Medicine. He attended Haverford College and received his MD from New York University. After internal medicine residency and chief residency, he trained in pulmonary and critical care medicine at the University of Colorado and the National Jewish Center in Denver where he did his research fellowship with David Riches and Peter Henson and gained expertise in interstitial lung diseases. He has held faculty positions at the Johns Hopkins Hospital and Yale University School of Medicine where he was a tenured Professor and started the interstitial lung disease clinics at both institutions. He then moved to Duke University where he was a tenured Professor and Chief of the Division of Pulmonary, Allergy and Critical Medicine before moving to Cedars-Sinai in 2013.

His laboratory has focused on the cellular and molecular mechanisms of unremitting lung inflammation and fibrosis. He defined the roles of endogenous matrix degradation products and host defense in regulating persistent lung inflammation. Over the last decade he has focused on mechanisms the lead to fibroblast activation and invasion in severe pulmonary fibrosis and the failure of alveolar progenitor cell renewal in idiopathic pulmonary fibrosis (IPF). He has also played a significant role in the clinical trial development of the only FDA-approved treatments for IPF. He still maintains an active clinical practice. His laboratory has been funded by the NIH since 1992. He is an elected member of the American Society of Clinical Investigation, Interurban Clinical Club and the Association of American Physicians where he currently serves on Council.

Expertise
Medicine

Research focus
pulmonary medicine
critical care
lung inflammation
fibrosis
host defense
clinical trials
epithelial cell biology
fibroblast biology

Experimental organism
human
mouse

Competing interests statement
The Noble Laboratory is supported by the National Institutes of Health (National Heart, Lung and Blood Institute (NHLBI) and National Institute of Allergy and Infectious Diseases (NIAID).
Martin Pollak

Harvard Medical School, United States

Martin Pollak, MD is the Chief for the Division of Nephrology and the George C. Reisman Professor of Medicine with Harvard Medical School.

Dr Pollak is a graduate of Princeton University and the New York University School of Medicine. He did clinical training in Internal Medicine at Columbia-Presbyterian Medical Center, completed a nephrology fellowship at the Brigham and Women’s Hospital, followed by postdoctoral research training in the Department of Genetics at Harvard Medical School in the laboratory of Jon and Christine Seidman. Dr. Pollak’s laboratory is interested in the molecular genetic basis of human kidney disease, with a particular focus on diseases of the glomerulus. His laboratory uses a combination of methods, including human genetics, mouse genetics, cell biology, and biochemical tools to understand the connection between phenotype and genotype and to understand glomerular physiology.

He was elected a member of the National Academy of Sciences in 2014, and received the American Society of Nephrology Homer W. Smith Award in 2017.

Expertise
Medicine
Genetics and Genomics

Research focus
nephrology
genetics
kidney
glomerulus

Experimental organism
human
mouse

Competing interests statement
Dr Pollak receives funding from the National Institutes of Health (NIH), the United States Department of Defense, and Vertex Pharmaceuticals. He is an Associated Editor for the Journal of the American Society of Nephrology and an ad hoc editor for PNAS.
W Kimryn Rathmell

Vanderbilt University Medical Center, United States

Dr Kimryn Rathmell is the Chair of Medicine and Physician-in-Chief at Vanderbilt University Medical Center. She is a physician-scientist studying the molecular biology of renal cell carcinomas and rare tumors of the kidney. She earned her MD and PhD in Biophysics at Stanford University. She completed internal medicine training at the University of Chicago and the University of Pennsylvania, and fellowship in medical oncology at the University of Pennsylvania. She joined Vanderbilt in 2015 to lead the Division of Hematology and Oncology.

Her research program focuses on understanding the molecular pathogenesis of renal cell carcinomas and spans early models of renal tumorigenesis, novel imaging strategies for diagnosis and screening of kidney cancer, epigenetic regulation of kidney cancers, metabolic features of tumorigenesis, and novel therapeutic strategies to overcome resistance to anti-angiogenic therapy and checkpoint targeted immunotherapy. With these bench to bedside strategies, her laboratory endeavors to integrate knowledge of pathways that promote cancer development with translational clinical studies, and uses these discoveries to develop robust approaches to improve the survival of patients with kidney cancers. She serves as the Deputy Director for Research Integration and Career Development for the Vanderbilt-Ingram Cancer Center and on the Board of Scientific Advisors for the National Cancer Institute.

Expertise
Cancer Biology
Medicine

Research focus
cancer biology
molecular biology
epigenetics
biomarkers
angiogenesis

Competing interests statement
Stock and Other Ownership Interests
Company: Sitryx (Recipient: An Immediate Family Member); Company: Caribou Publishing (Recipient: An Immediate Family Member); Company: Nirogy Therapeutics (Recipient: An Immediate Family Member)Honoraria
Company: Merck (Recipient: An Immediate Family Member); Company: Pfizer (Recipient: An Immediate Family Member)Consulting or Advisory Role
Company: Sitryx (Recipient: An Immediate Family Member); Company: caribou Biosciences (Recipient: An Immediate Family Member)Research Funding
Company: Incyte (Recipient: An Immediate Family Member); Company: Calithera Biosciences (Recipient: An Immediate Family Member); Company: Tempus (Recipient: An Immediate Family Member); Company: Peloton Therapeutics (Recipient: Institution); Company: Pfizer (Recipient: Institution); Company: Genentech (Recipient: Institution); Company: E.R. Squibb Sons, LLC (Recipient: Institution)Patents, Royalties, Other Intellectual Property
ClearCode34 Risk prediction biomarker for kidney cancer; hERV 3-2 expression as a biomarker of response to immunotherapyOpen Payments Link
Jonathan Roiser

University College London, United Kingdom

Jonathan Roiser is Professor of Neuroscience and Mental Health and Deputy Director at the UCL Institute of Cognitive Neuroscience. His research interests lie in understanding the brain and psychological processes driving mental health problems, especially disrupted motivation in depression. He has published over 150 peer-reviewed papers and his recent research has been funded by Wellcome, the MRC, the Leverhulme Trust and the Rosetrees Trust. He founded and directs two PhD schemes: the UCL-NIMH Joint Doctoral Training Program in Neuroscience and the UCL Wellcome 4-year PhD Programme in Mental Health Science.

Expertise
Neuroscience
Medicine

Research focus
mental health
neuroimaging
behavior
psychopharmacology
computational modelling

Experimental organism
human

Competing interests statement
I hold active grants from Rosetrees, Wellcome and the Leverhulme Trust. I supervise an ongoing PhD studentship co-funded by MRC and Cambridge Cognition Ltd. I have performed paid consultancy work for GE Ltd within the last 3 years. I sit on the Editorial Board of Current Opinion in Behavioral Sciences.
Lois Smith

Harvard Medical School, Children's Hospital Boston, United States

Lois EH Smith MD, PhD is an ophthalmologist and clinician/scientist at Boston Children’s Hospital and Professor of Ophthalmology at Harvard Medical School. Her basic research work is in retinal neovascularization, both basic mechanism and treatment including diabetic retinopathy, retinopathy of prematurity, age-related macular degeneration and retinitis pigmentosa.

She has a long standing interest in eye diseases particularly retinopathy of prematurity, diabetic retinopathy, and AMD and in the mechanisms behind these diseases, particularly the underlying causes of neovascularization and the interactions between neurons and vessels. Many pathways that they have found have been translated into clinical trials, including replacement of IGF-1 in preterm infants and treatment of AMD with anti-VEGF antibodies in which they were the first to show the benefit of blocking VEGF in a mouse model of retinopathy. More recently Dr Smith's work has been interested in metabolic function in photoreceptors, particularly with respect to lipids. Photoreceptor metabolic dysfunction causes central vision loss in retinal degenerative diseases (including ROP) but is also implicated in age-related macular degeneration and diabetic retinopathy.

Dr Smith is the recipient of the Friedenwald award, the Alcon Research Institute award, the Silverman award, and the Bressler Prize.

Expertise
Developmental Biology
Medicine
Neuroscience

Research focus
age-related macular degeneration
diabetic eye disease
retinopathy
ocular disease
developmental neuroscience

Competing interests statement
Dr Smith has received funding from the National Eye Institute, Massachusetts Lions Eye Research Fund, the European Union, the Lowy Medical Research Institute, Foundation Fighting Blindness, Research to Prevent Blindness Senior Investigator Award, and the Alcon Award.Current editor roles include: Editor for Ophthalmology (Science), Editor for Journal of Clinical Ophthalmology, and Editor IOVS (Investigative Ophthalmology and Visual Science).
Hiroshi Takayanagi

The University of Tokyo, Japan

Hiroshi Takayanagi, MD, PhD graduated from the Faculty of Medicine, University of Tokyo in 1990. Originally trained as an orthopaedic surgeon and rheumatologist in the Department of Orthopaedic Surgery, University of Tokyo, Dr Takayanagi began his basic research career in 1996. He was awarded his PhD in 2001 by the University of Tokyo and became Assistant Professor at the Department of Immunology where he studied the regulation of bone metabolism by the immune system by focusing on the control of osteoclast differentiation. In 2012, he was promoted to Professor, Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo. Dr Takayanagi received the 2019 Japan Academy Prize for his studies on osteoimmunology.

Expertise
Immunology and Inflammation
Medicine

Research focus
arthritis
osteoporosis
immune tolerance
osteoimmunology
autoimmunity
fibroblast
osteoclast
T cells

Competing interests statement
Hiroshi Takayanagi has received funding from the Ministry of Education, Culture, Sports, Science & Technology, the Japan Agency for Medical Research and Development, and Japan Society for the Promotion of Science.He is an Editorial Board Member of Annals of the Rheumatic Diseases and Bone Research, an Associate Editor of Inflammation and Regeneration and Journal of Bone and Mineral Metabolism, and a Transmitting Editor of Modern Rheumatology.
Jos WM van der Meer

Radboud University Medical Centre, Netherlands

Jos WM van der Meer is emeritus Professor of Medicine at Radboud University Nijmegen, The Netherlands. Between 1992 and 2012 he was head of the Department of internal medicine at the Radboud University Medical Centre. His major areas of expertise are host defence against infection, trained immunity, autoinflammation, immunodeficiency and antimicrobial policy.

Expertise
Medicine
Microbiology and Infectious Disease

Research focus
infectious disease and host defense
innate immunity
trained immunity
immunodeficiency
autoinflammatory diseases
chronic fatigue syndrome

Experimental organism
human
mouse

Competing interests statement
Jos WM van der Meer is a member of the Royal Netherlands Academy of Arts and Sciences (KNAW), for which he served as a vice-president from 2005 to 2011. He is a member of Academia Europaea and he is past-president of EASAC, the European Academies Science Advisory Council. He is an honorary Fellow of the Royal College of Physicians in London and in Edinburgh and a fellow of the Infectious Diseases Society of America and of the European Society of Clinical Microbiology and Infectious diseases. He is a member of the Dutch National Board for Research Integrity LOWI. He received a number of prices and awards, such as the Gold Hijmans van den Bergh medal. He was awarded knighthood in the order of the Netherlands Lion in 2003.
Gary Westbrook

Vollum Institute, United States

Gary Westbrook is a Senior Scientist at the Vollum Institute and Rocky and Julie Dixon Professor of Neurology at Oregon Health & Science University. Dr. Westbrook is a member of the National Academy of Medicine (formerly Institute of Medicine), the American Academy of Arts and Sciences, and past editor-in-chief of the Journal of Neuroscience. He has received Javits and Merit awards from NIH for his research as well as an International Cooperation Award from the Max Planck Society. Dr. Westbrook received his medical training and did graduate study in Biomedical Engineering at Case Western Reserve University, followed by residencies in Internal Medicine and Neurology, and basic neuroscience research at the National Institutes of Health in Bethesda. Earlier work in his lab was mostly directed at the level of receptors, particularly N-methyl-D-aspartate (NMDA) receptors, and the function of single synapses. The emphasis has now largely shifted to studies of small networks (microcircuits) in the hippocampus. Dr. Westbrook maintains interests in clinical neurology, particularly epilepsy, as well as graduate research training. He was co-Director of the Vollum Institute (2005-2015) and director of the Neuroscience Graduate Program at Vollum/OHSU (2008-2018).

Expertise
Neuroscience
Medicine

Research focus
synaptic transmission
synaptic plasticity
ligand-gated ion channels
hippocampus
olfactory bulb
epilepsy
in vitro physiology
activity-dependent gene expression

Experimental organism
mouse

Competing interests statement
Gary Westbrook is employed by Oregon Health and Science University. He receives research and training funding from the National Institutes of Health and the Ellison Medical Foundation. He is a member of the National Academy of Medicine (formerly Institute of Medicine) and the American Academy of Arts and Sciences. He serves on Scientific Advisory Boards for Max Planck Institutes in Göttingen (MPIEM) and Florida (MPFI), the Myelin Repair Foundation, and on study sections for the National Institutes of Health. He is currently a member of editorial boards for Physiological Reviews and Philosophical Transactions of the Royal Society B.
Richard M White

Memorial Sloan Kettering Cancer Center, United States

Richard White, M.D., Ph.D, is a physician-scientist at the Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College. He is interested in basic mechanisms underlying metastasis, using the zebrafish as a model system. His work has established numerous techniques for cancer modeling and high-resolution imaging in the fish. Using these tools, the lab is focused on the cross-talk between tumor cells and the microenvironment, and how this interplay influences metastatic success. His work has revealed novel interactions between melanoma cells and adipocytes in the microenvironment, and how neural crest programs play roles in melanoma progression. He has been awarded the NIH Director’s New Innovator Award, the Pershing Square Foundation Award, and the Mark Foundation ASPIRE award.

Expertise
Cancer Biology
Cell Biology
Developmental Biology
Medicine

Research focus
development
neural crest
zebrafish
cancer
melanoma
metastasis
microenvironment

Experimental organism
zebrafish

Competing interests statement
Richard White receives funding from the National Institutes of Health, the Pershing Square Sohn Foundation, the Mark Foundation, the Melanoma Research Alliance, the American Cancer Society and the Harry J. Lloyd Foundation. He receives consulting fees from N-of-One, Inc.
Ma-Li Wong

State University of New York Upstate Medical University, United States

Ma-Li Wong, MD, PhD, FRANZCP, is Professor in the Department of Psychiatry and Behavioral Sciences, and Neurosciences and Physiology at SUNY Upstate Medical University. She was born in Hong Kong and grew up in Brazil, where she graduated from the University of São Paulo School of Medicine (FMUSP). She had clinical and research training in psychiatry at Albert Einstein College of Medicine, NIH, and Yale University. Ma-Li Wong is a bench, clinical and translational researcher in the biology of depression and co-morbid conditions, chronic stress, and antidepressant drugs. She has conducted research for over 30 years at Yale (Chief Resident and Instructor), National Institutes of Health (Unit Chief), University of California, Los Angeles (Professor), University of Miami (Professor and Vice-Chair), and in Australia (Australian National University, South Australian Health and Medical Research Institute, and Flinders University). She was the recipient of the following awards: Milton Rosenbaum Award for Psychiatric Research (1989); Lilly Psychiatric Research Fellowship by the American Psychiatric Association (1990); SmithKline Beecham Award by the Society of Biological Psychiatry (1990); APA/Dista Research Award (1993); NIH Fare Award (1996 and 1997); Henry L. Moses Award by the Montefiore Medical Center (1998). She co-edited two books: Pharmacogenomics: The Search for Individualized Therapeutics (2002) and Biology of Depression: From Novel Insights to Therapeutic Strategies (2005).

Expertise
Medicine
Neuroscience

Research focus
major depression
chronic stress
neuroinflammation
neuroendocrinology
pharmacogenomics
genetics
obesity
leptin

Experimental organism
human
mouse
primary cells
immortalized cells

Competing interests statement
Ma-Li Wong is an Associate Editor for Molecular Psychiatry. She has been funded by organizations such as the NIH in the US and the National Health and Medical Research Council in Australia.
Mone Zaidi

Icahn School of Medicine at Mount Sinai, United States

Mone Zaidi graduated in medicine from King George’s Medical College, India, and trained clinically at the Hammersmith Hospital, London, under the tutelage of Iain MacIntyre, FRS. After obtaining a PhD and MD from the University of London, Dr Zaidi held appointments as Lecturer at the Royal Postgraduate Medical School and Senior Lecturer and Honorary Consultant at St. George’s Hospital Medical School for over 8 years. In 1999, he moved to Mount Sinai School of Medicine in New York as Professor of Medicine and Founding Director of The Mount Sinai Bone Program. Zaidi has discovered mechanisms of skeletal homeostasis in health and its dysregulation in common and rare diseases. These studies, spanning over 30 years, included the first description of calcium sensing in the osteoclast and the discovery that locally released nitric oxide acts to suppress bone removal. In 2003, his group published evidence for a pituitary–bone axis of medical significance, in which pituitary hormones affect the skeleton directly. More recently, he found that inhibiting FSH not only increased bone mass, but also reduced body fat and increased thermogenesis – in essence, laying the firm foundation for his new humanized monoclonal FSH antibody to treat both osteoporosis and obesity. This corpus of work was selected by Nature Medicine as one of eight “Notable Advances” in biomedicine for 2017. Zaidi’s research was funded by the Medical Research Council of the UK, and since 1997, by the US National Institutes of Health. He is an elected member of the American Society for Clinical Investigation, Association of American Physicians, the Interurban Clinical Club (established by Sir William Osler in 1905) of which he was President, the Practitioners’ Society of New York (the oldest medical society in the US), and the Association of Professors of Medicine. Zaidi was made Master of the American College of Physicians, received the Harrington Scholar-Innovator Award, was elected as Fellow of the American Association of Advancement of Science, and is recipient of three honorary doctorates.

Expertise
Medicine

Research focus
osteoporosis
obesity
bone mass
metabolism
adipose tissue
endocrine physiology
pituitary hormones
FSH

Competing interests statement
Mone Zaidi is currently funded by the National Institute on Aging and the National Institute of Diabetes, Digestive and Kidney Diseases of the NIH. He is inventor on several patents in relation to his work on FSH, bone and body composition. He is currently Consulting Editor for the Journal of Clinical Investigation, Editor of a series – Marrow – of the Annals of the New York Academy of Sciences, and Editor-in-chief of the Encyclopedia of Bone Biology, published by Elsevier as their Major Reference Works.

Reviewing editors

Yousef Abu-Amer

Washington University School of Medicine, United States

Expertise
Cell Biology
Immunology and Inflammation
Medicine

Research focus
osteolysis
osteoclast
osteoarthritis
osteoimmunology
inflammatory arthritis
RANKL
Cheryl Ackert-Bicknell

University of Colorado, United States

Expertise
Medicine
Genetics and Genomics

Research focus
bone
bone biology
genetics
musculoskeletal
aging

Experimental organism
mouse
rat
Iannis E Adamopoulos

Harvard Medical School, United States

Expertise
Immunology and Inflammation
Medicine

Research focus
osteoclasts
arthritis
psoriatic arthritis
interleukin 23
interleukin 17
RANKL
Anurag Agrawal

CSIR Institute of Genomics and Integrative Biology, India

Expertise
Medicine

Research focus
asthma
respiratory diseases

Experimental organism
human
mouse
Olujimi A Ajijola

University of California, Los Angeles, United States

Expertise
Medicine

Research focus
cardiovascular
neurobiology
sympathetic nerves
ventricular arrhythmias
RNA sequencing
David B Allison

Indiana University, United States

Expertise
Medicine
Genetics and Genomics
Epidemiology and Global Health
Computational and Systems Biology
Evolutionary Biology

Research focus
experimental design
statistics
longevity
biostatistics
obesity
nutrition
senescence
research rigour
science integrity
Joon-Yong An

Korea University, South Korea

Expertise
Medicine
Computational and Systems Biology
Genetics and Genomics
Neuroscience

Research focus
whole genome sequencing
noncoding mutation
neurodevelopment
autism spectrum disorders
multi-omics
Cynthia L Andoniadou

King's College London, United Kingdom

Expertise
Developmental Biology
Medicine
Stem Cells and Regenerative Medicine

Research focus
stem cells
endocrine
pituitary gland
adrenal gland
paracrine signalling
tumours

Experimental organism
human
mouse
Wadih Arap

Rutgers Cancer Institute of New Jersey at University Hospital, United States

Expertise
Medicine
Cancer Biology

Research focus
clinical oncology
genitourinary (GU) cancers
prostate cancer
Hossein Ardehali

Northwestern University, United States

Expertise
Medicine
Biochemistry and Chemical Biology

Research focus
mitochondria
iron
glucose metabolism
mRNA-binding proteins
hexokinases
metabolism
cardiac biology
Mohammad Athar

University of Alabama at Birmingham, United States

Expertise
Medicine

Research focus
dermatology
skin diseases
skin biochemistry
skin cancer
Robert Baiocchi

The Ohio State University, United States

Expertise
Medicine
Cancer Biology
Immunology and Inflammation

Research focus
Epstein Barr Virus
lymphoma
cancer therapeutics
cancer vaccines
cancer immunology
cancer immunotherapy
cancer epigenetics
Muthuswamy Balasubramanyam

ICMR Emeritus Scientist, Madras Diabetes Research Foundation, India

Expertise
Medicine
Biochemistry and Chemical Biology
Cancer Biology
Cell Biology
Developmental Biology
Epidemiology and Global Health
Genetics and Genomics
Immunology and Inflammation
Neuroscience
Stem Cells and Regenerative Medicine

Research focus
disease biology
diabetes
aging
omnics
calcium signaling
endocrine disruptors
probiotics
molecular medicine
Audrey M Bernstein

State University of New York Upstate Medical University, United States

Expertise
Cell Biology
Medicine
Stem Cells and Regenerative Medicine

Research focus
cornea
scarring
fibrosis
glaucoma
integrins
myofibroblast
José Biurrun Manresa

National Scientific and Technical Research Council (CONICET), National University of Entre Ríos (UNER), Argentina

Expertise
Medicine
Neuroscience

Research focus
pain
nociceptive system
EEG
EMG
biomedical signal processing
biostatistics
Jonathan S Bogan

Yale School of Medicine, United States

Expertise
Medicine
Cell Biology

Research focus
insulin
protein trafficking
metabolism
type 2 diabetes
Marc J Bonten

University Medical Center Utrecht, Netherlands

Expertise
Epidemiology and Global Health
Microbiology and Infectious Disease
Medicine

Research focus
epidemiology
antibiotic resistance
healthcare-associated infections
prevention
clinical trials
Philip Boonstra

University of Michigan, United States

Expertise
Medicine
Epidemiology and Global Health
Cancer Biology
Genetics and Genomics

Research focus
biostatistics
clinical trials
cancer biostatistics
epidemiology
ECMO
statistical programming
Annelien Bredenoord

University Medical Centre Utrecht, Netherlands

Expertise
Medicine

Research focus
bioethics
medical ethics
ethics
Christoph Buettner

Rutgers Robert Wood Johnson Medical School, United States

Expertise
Medicine

Research focus
metabolism
diabetes
Christopher Cardozo

Icahn School of Medicine at Mount Sinai, United States

Expertise
Medicine

Research focus
spinal cord injury
muscle biology
sarcopenia
muscle physiology

Experimental organism
mouse
rat
Dirce M Carraro

AC Camargo Cancer Center, Brazil

Expertise
Medicine
Cancer Biology

Research focus
oncology
cancer genomics
Alesha Castillo

New York University Bioengineering Institute, United States

Expertise
Medicine
Stem Cells and Regenerative Medicine

Research focus
bone
mechanobiology
mechanical loading
fracture repair
skeletal stem and progenitor cells
osteoblasts
osteogenesis
aging
Howard Y Chang

Stanford University, United States

Expertise
Medicine
Chromosomes and Gene Expression
Genetics and Genomics

Research focus
cancer
immunotherapy
RNA
genomics
epigenomics
dermatology

Experimental organism
human
mouse
Snigdha Chaturvedi

University of North Carolina, Chapel Hill, United States

Expertise
Medicine

Research focus
nature language processing
narrative understanding
Hina W Chaudhry

Icahn School of Medicine at Mount Sinai, United States

Expertise
Medicine
Stem Cells and Regenerative Medicine

Research focus
cardiac regeneration
cardiomyocytes
developmental genetics
stem cell biology
regenerative biology
Di Chen

Shenzhen Institute of Advanced Technology, China

Expertise
Medicine

Research focus
bone disease
Iacopo Chiodini

Ospedale Niguarda Ca' Granda, Italy

Expertise
Medicine

Research focus
adrenal gland
bone metabolism
osteoporosis
calcium metabolism
bone fragility
Jungmin Choi

Korea University College of Medicine, South Korea

Expertise
Cancer Biology
Computational and Systems Biology
Genetics and Genomics
Medicine

Research focus
rare disorders
single cell genomics
computational biology
human genomics
Sarah E Cobey

University of Chicago, United States

Expertise
Microbiology and Infectious Disease
Ecology
Evolutionary Biology
Epidemiology and Global Health
Medicine

Research focus
B cells
coevolution
infectious disease dynamics
influenza
mathematical modelling
vaccination
Graziana Colaianni

University of Bari, Italy

Expertise
Medicine
Cell Biology
Stem Cells and Regenerative Medicine

Research focus
bone
osteoporosis
muscle
sarcopenia
cartilage
muscle atrophy

Experimental organism
mouse
human
Yali Cong

Peking University Health Science Center, China

Expertise
Medicine

Research focus
medical ethics
bioethics
Alex R Cook

National University of Singapore, Singapore

Expertise
Epidemiology and Global Health
Microbiology and Infectious Disease
Medicine

Research focus
infectious disease epidemiology
mathematical modelling
biostatistics
health policy
Seth J Corey

Cleveland Clinic, United States

Expertise
Cancer Biology
Medicine

Research focus
myeloid malignancies
inherited or acquired bone marrow failure
neutrophils
platelets zebrafish
cancer evolution
proteostasis
Jennifer Cullen

Case Western Reserve University, United States

Expertise
Epidemiology and Global Health
Medicine

Research focus
cancer population sciences
Ilse S Daehn

Icahn School of Medicine at Mount Sinai, United States

Expertise
Medicine
Cell Biology

Research focus
mitochondria
glomerular disease
podocyte
endothelial cells
reactive oxygen species
Emek Demir

Oregon Health and Science University, United States

Expertise
Cancer Biology
Computational and Systems Biology
Genetics and Genomics
Medicine

Research focus
proteomics
Alok Dhawan

Centre of Biomedical Research, India

Expertise
Medicine
Ecology

Research focus
molecular epidemiology
DNA damage and repair
genetic toxicology
nanomaterial toxicology
environmental health
Rajan Dighe

Indian Institute of Science Bangalore, India

Expertise
Medicine

Research focus
reproductive endocrinology
Ana Domingos

University of Oxford, United Kingdom

Expertise
Medicine
Neuroscience

Research focus
metabolism
obesity
neuroimmunity
autonomic nervous system
eating behaviour
inflammation
Hannelore Ehrenreich

Max Planck Institute of Experimental Medicine, Germany

Expertise
Genetics and Genomics
Immunology and Inflammation
Medicine
Neuroscience

Research focus
translational neuroscience
erythropoietin
hypoxia
neuropsychiatric phenotypes
deep phenotyping
autoantibodies

Experimental organism
human
Joel K Elmquist

UT Southwestern Medical Center, United States

Expertise
Neuroscience
Medicine
Genetics and Genomics

Research focus
metabolism
obesity
diabetes
hypothalamus
feeding
autonomic
exercise

Experimental organism
mouse
D. melanogaster
Noriaki Emoto

Kobe Pharmaceutical University, Japan

Expertise
Medicine

Research focus
cardiology
pulmonary hypertension
endothelin
pharmacology
vascular biology
John Ewer

Universidad de Valparaiso, Chile

Expertise
Developmental Biology
Neuroscience
Genetics and Genomics
Medicine

Research focus
animal behaviour
neuropeptides
circadian clocks
insect endocrinology

Experimental organism
D. melanogaster
Alberto Falchetti

Istituto Auxologico Italiano , IRCCS, Italy

Expertise
Medicine

Research focus
metabolic bone disease
Paget's disease of bone
familial primary hyperparathyroidism
multiple endocrine neoplasia type 1
Edward A Fisher

New York University Grossman School of Medicine, United States

Expertise
Medicine
Cell Biology

Research focus
preventive cardiology
cardiology
lipoprotein metabolism
atherosclerosis

Experimental organism
mouse
Jonathan Flint

University of California, Los Angeles, United States

Expertise
Genetics and Genomics
Medicine

Research focus
genetics
genomics
psychiatric disorders
Zhongjie Fu

Boston Children's Hospital/Harvard Medical School, United States

Expertise
Medicine

Research focus
retinal vasculature
retinopathy
adiponectin
Eric D Gaier

Boston Children's Hospital, United States

Expertise
Medicine
Neuroscience

Research focus
ophthalmology
amblyopia
strabismus
Luigi Gennari

University of Siena, Italy

Expertise
Medicine

Research focus
metabolic bone disease
Paget's disease of bone
endocrinology
Gregory G Germino

National Institute of Diabetes and Digestive and Kidney Diseases, United States

Expertise
Medicine
Genetics and Genomics

Research focus
nephrology
genetic renal disease
internal medicine
ciliopathies

Experimental organism
mouse
rat
human
Evangelos J Giamarellos-Bourboulis

Attikon University Hospital, Greece

Expertise
Immunology and Inflammation
Microbiology and Infectious Disease
Genetics and Genomics
Medicine

Research focus
sepsis
hidradenitis suppurativa
pathogenesis of infection
biomarkers
David Ginsburg

University of Michigan, United States

Expertise
Medicine
Genetics and Genomics

Research focus
hemostasis
thrombosis
protein secretion
human genetics
fibrinolysis

Experimental organism
human
mouse
zebrafish
Yelena Ginzburg

Icahn School of Medicine at Mount Sinai, United States

Expertise
Medicine

Research focus
iron metabolism
erythropoiesis
thalassemia
myeloproliferative neoplasms
hemochromatosis
transferrin
hepcidin
erythroferrone
Joseph G Gleeson

The Rockefeller University, United States

Expertise
Medicine
Neuroscience
Developmental Biology

Research focus
neurodevelopmental disease
brain development
neurogenetics
autism
epilepsy
intellectual disability
organoid
stem cells
genomics
bioinformatics

Experimental organism
human
mouse
Pablo A González

Pontificia Universidad Católica de Chile, Chile

Expertise
Medicine
Microbiology and Infectious Disease

Research focus
host-pathogen interactions
dendritic cells
T cells
herpesviruses
bacteria
immune evasion
viruses

Experimental organism
mouse
Ki Goosens

ki.goosens@mssm.edu, United States

Expertise
Neuroscience
Medicine

Research focus
chronic stress
translational science
systems neuroscience
brain-body interactions
Timothy D Griffiths

Newcastle University, United Kingdom

Expertise
Neuroscience
Medicine

Research focus
auditory
cognition
neurology
imaging

Experimental organism
human
macaque
Yogesh K Gupta

The University of Texas Health Science Center at San Antonio, United States

Expertise
Medicine
Structural Biology and Molecular Biophysics
Cancer Biology
Microbiology and Infectious Disease

Research focus
drug discovery
nucleic acid modifications
cancer epigenetics
structures of viral proteins
host-pathogen interactions
Adam Haber

Harvard TH Chan School of Public Health, United States

Expertise
Computational and Systems Biology
Genetics and Genomics
Medicine

Research focus
asthma
machine learning
William C Hahn

Dana-Farber Cancer Institute, United States

Expertise
Cancer Biology
Genetics and Genomics
Medicine

Research focus
cancer
transformation
functional genomics
RAS
YAP1

Experimental organism
human
Shozeb Haider

University College London, United Kingdom

Expertise
Medicine
Structural Biology and Molecular Biophysics
Computational and Systems Biology
Microbiology and Infectious Disease

Research focus
X-ray crystallography
molecular dynamics simulations
allostery
structure-based drug design
structural bioinformatics
computational chemistry
nucleic acids
rare diseases
Sang Jun Han

Baylor College of Medicine, United States

Expertise
Medicine
Cell Biology

Research focus
nuclear receptors
steroid receptor coactivator
endometriosis
female infertility
Gaiti Hasan

Tata Institute of Fundamental Research, National Centre for Biological Sciences, India

Expertise
Genetics and Genomics
Neuroscience
Medicine

Research focus
calcium signaling
motor function
regulation of gene expression
IP3R
STIM
Orai

Experimental organism
D. melanogaster
Shannon M Hawkins

Indiana University School of Medicine, United States

Expertise
Medicine

Research focus
endometriosis
ovarian cancer
endometrial cancer
Daniel Henrion

University of Angers, France

Expertise
Cell Biology
Medicine

Research focus
vascular biology
endothelium
blood flow
vascular remodeling
hypertension
blood pressure
shear stress
vascular diseases
Elizabeth P Henske

Brigham And Women's Hospital, United States

Expertise
Medicine
Cancer Biology

Research focus
tuberous sclerosis complex
lymphangioleiomyomatosis
mTOR
prostate cancer
Stephanie Hicks

Johns Hopkins Bloomberg School of Public Health, United States

Expertise
Medicine
Computational and Systems Biology
Genetics and Genomics

Research focus
single cell genomics
statistics
data science
data analysis
bioinformatics
computational biology
spatial genomics
Kenneth Ho

Garvan Institute of Medical Research, Australia

Expertise
Medicine

Research focus
metabolism
sarcopenia
Patrick J Hu

Vanderbilt University School of Medicine, United States

Expertise
Medicine
Developmental Biology
Genetics and Genomics

Research focus
signal transduction
genetics
development
aging
cancer
endoplasmic reticulum homeostasis
dauer

Experimental organism
C. elegans
Christopher L-H Huang

University of Cambridge, United Kingdom

Expertise
Medicine

Research focus
cardiac arrhythmias
atrial fibrillation
skeletal muscle
electrophysiology
ion channels
action potential propagation
genetically modified mice
patch clamping

Experimental organism
mouse
Susie Y Huang

Massachusetts General Hospital, United States

Expertise
Medicine
Neuroscience

Research focus
development
translation
magnetic resonance imaging
Bradley Hyman

Massachusetts General Hospital, United States

Expertise
Medicine
Neuroscience

Research focus
tau
alzheimer
neuropathology
Jameel Iqbal

Icahn School of Medicine at Mount Sinai, United States

Expertise
Medicine

Research focus
general pathology
blood banking
transfusion medicine
transplantation immunology
clinical pathology
Edward D Janus

University of Melbourne, Australia

Expertise
Epidemiology and Global Health
Medicine

Research focus
cardiovascular disease
diabetes
prevention
chronic diseases
clinical guidelines
Jae-Wook Jeong

University of Missouri – Columbia, United States

Expertise
Medicine
Cancer Biology

Research focus
estrogen
endometriosis
uterus
endometrium
endometrial cancer
implantation
decidualization
progesterone
Prabhat Jha

Saint Michael's Hospital, Canada

Expertise
Epidemiology and Global Health
Microbiology and Infectious Disease
Medicine

Research focus
epidemiology
global health
infectious disease and population dynamics
randomized controlled trials
Yaoting Ji

Wuhan University, China

Expertise
Medicine
Stem Cells and Regenerative Medicine
Cell Biology

Research focus
osteoporosis
obesity
stem cell differentiation
aging
beiging
skeletal mineralization
bone resorption
Jean Jiang

The University of Texas Health Science Center at San Antonio, United States

Expertise
Medicine
Cell Biology
Cancer Biology

Research focus
gap junctions
hemichannels
connexins
bone biology
osteocyte
bone mechanobiology
cancer bone metastasis
lens biology
Mohammad M Karimi

Kings College London, United Kingdom

Expertise
Medicine
Computational and Systems Biology

Research focus
bioinformatics
genomics
epigenomics
transposable elements
single-cell sequencing
visual analytics
epigenetic therapy
Gerard Karsenty

Columbia University, United States

Expertise
Genetics and Genomics
Medicine

Research focus
endocrinology
bone biology
physiology
bone endocrinology
Brian S Kim

Icahn School of Medicine at Mount Sinai, United States

Expertise
Medicine
Immunology and Inflammation
Neuroscience

Research focus
basophil
cytokine
innate lymphoid cell
itch
mast cells
neuroimmunology
sensory neuron
somatosensation
Se-Min Kim

Icahn School of Medicine at Mount Sinai, United States

Expertise
Medicine

Research focus
metabolic bone disease
diabetic bone disease
thyroid bone disease
phosphodiesterase (PDE)5
PDE11
Melanie Königshoff

University of Colorado, United States

Expertise
Stem Cells and Regenerative Medicine
Medicine
Cell Biology

Research focus
lung regeneration
wnt signaling
pulmonary fibrosis
chronic obstructive pulmonary disease
epithelial cell biology

Experimental organism
human
mouse
Smita Krishnaswamy

Yale School of Medicine, United States

Expertise
Medicine

Research focus
bioinformatics
computational genomics
immunology
immunotherapy
cancer
neuroscience
developmental biology
T Rajendra Kumar

University of Colorado, United States

Expertise
Cell Biology
Developmental Biology
Medicine

Research focus
reproductive endocrinology
reproductive biology
pituitary
testis
ovary

Experimental organism
mouse
Dan Larhammar

Uppsala University, Sweden

Expertise
Medicine
Evolutionary Biology
Neuroscience
Cell Biology
Chromosomes and Gene Expression
Genetics and Genomics

Research focus
evolution
gene/genome duplications
cellular and molecular neuroscience
G protein-coupled receptors (GPCR)
neuropeptides
endocrine peptides
phototransduction
ligand-gated ion channels

Experimental organism
human
zebrafish
Rauf Latif

Icahn School of Medicine at Mount Sinai, United States

Expertise
Cell Biology
Medicine
Stem Cells and Regenerative Medicine

Research focus
metabolic syndrome
thyroid
GPCRs
glycoprotein hormone receptors
TSH receptor
thyroid hormones
receptor oligomerization
post translational modification of receptors

Experimental organism
mouse
Sihoon Lee

Gachon University College of Medicine, South Korea

Expertise
Medicine
Genetics and Genomics

Research focus
endocrinology
hormones
parathyroid
bone metabolism
rare diseases
thyroid hormone metabolism
deiodinase
insulin resistance
Ellis Levin

University of California, Irvine, United States

Expertise
Medicine

Research focus
signal transduction in cells
steroid receptors
Hongliang Li

Wuhan University School of Medicine, China

Expertise
Biochemistry and Chemical Biology
Computational and Systems Biology
Epidemiology and Global Health
Immunology and Inflammation
Medicine

Research focus
cardiometabolic disease
metabolic disease
vascular injury
animal models
liver
innate immunity
Yi-Ping Li

Tulane University, United States

Expertise
Medicine

Research focus
orthopaedics
surgery
remodeling
dental/craniofacial defects
Paloma B Liton

Duke University School of Medicine, United States

Expertise
Medicine
Cell Biology

Research focus
ophthalmology
glaucoma
trabecular meshwork
autophagy
mechanical stretch
lysosomes
senescence
lysosomal enzymes
fibrosis
Huiping Liu

Northwestern University, United States

Expertise
Medicine
Cancer Biology

Research focus
cancer stem cells
circulating tumor cells
exosome
cancer immunity
metastasis
breast cancer
Nianjun Liu

Indiana University Bloomington, United States

Expertise
Medicine

Research focus
biostatistics
applied statistics
computational methods
human health and diseases
Peng Liu

Icahn School of Medicine at Mount Sinai, United States

Expertise
Medicine
Cell Biology

Research focus
obesity
aging
osteoporosis
Adipose Biology
Bone Biology (osteoblasts and osteoclasts)
Xiaorong Liu

University of Virginia, United States

Expertise
Neuroscience
Medicine

Research focus
retina
retinal ganglion cell
retinal degeneration
glaucoma
in vivo imaging
optic nerve
axon bundles

Experimental organism
mouse
tree shrew
Daria Lizneva

Icahn School of Medicine at Mount Sinai, United States

Expertise
Medicine

Research focus
endocrinology
polycystic ovary syndrome (PCOS)
Francesc Lopez-Giraldez

Yale University, United States

Expertise
Medicine

Research focus
bioinformatics
Helen H Lu

Columbia University, United States

Expertise
Medicine
Stem Cells and Regenerative Medicine

Research focus
bioengineering
biomechanics
orthopaedics
tissue engineering
Andrew MacPherson

University of Bern, Switzerland

Expertise
Immunology and Inflammation
Medicine

Research focus
mucosal immunity
function of IgA
mechanisms of host-microbial mutualism
Elham Mahmoudi

University of Michigan, United States

Expertise
Medicine
Epidemiology and Global Health

Research focus
health services research
large data analysis
econometrics and methodology
economics of dementia
economics of aging
disability
healthcare cost and utilization
disparity in health and healthcare
Arduino A Mangoni

Flinders Medical Centre, Australia

Expertise
Medicine

Research focus
pharmacology
drug safety
metabolomics
biomarkers
drug discovery
hypertension
Arya Mani

Yale University School of Medicine, United States

Expertise
Medicine
Genetics and Genomics

Research focus
lipid metabolism
glucose metabolism
fatty liver disease
hyperlipidemia
cardiovascular genetics

Experimental organism
mouse
Gherardo Mazziotti

Humanitas University of Milan, Italy

Expertise
Medicine

Research focus
endocrinology
pituitary disease
growth hormone
thyroid
FSH
thyroid diseases
secondary osteoporosis
insulin-like growth factor-1
ACTH
cortisol
prolactin
TSH
PTH
Gillian J McLellan

University of Wisconsin-Madison, United States

Expertise
Medicine
Cell Biology
Neuroscience
Chromosomes and Gene Expression

Research focus
ophthalmology
pathology
imaging
glaucoma
retina
optic nerve
animal models
Rui Medeiros

Instituto Português de Oncologia-Porto, Portugal

Expertise
Medicine
Cancer Biology

Research focus
oncology
molecular oncology
viral pathology
Simón Méndez-Ferrer

University of Cambridge, United Kingdom

Expertise
Stem Cells and Regenerative Medicine
Developmental Biology
Cancer Biology
Medicine

Research focus
haematopoietic stem cell niche
mesenchymal stem cells
myeloproliferative neoplasms
acute myeloid leukemia
neuroimmunology
Pramod Mistry

Yale School of Medicine, United States

Expertise
Medicine

Research focus
gaucher disease
lysosomal diseases
genomics of liver disease
metabolic liver diseases
sphingolipids and inflammation
Subburaman Mohan

Loma Linda University, United States

Expertise
Medicine
Genetics and Genomics

Research focus
bone biology
endochondral bone formation
insulin-like growth factors
osteoporosis
osteoarthritis
skeletal development

Experimental organism
human
Zsolt Molnár

CytoSorbents Europe GmbH, Germany
University of Pécs, Hungary

Expertise
Medicine

Research focus
sepsis
septic shock
hemodynamic monitoring
fluid therapy
extracorporeal cytokine removal
Tomohiro Morio

Tokyo Medical and Dental University, Japan

Expertise
Immunology and Inflammation
Medicine

Research focus
primary immunodeficiency
pediatrics
cell therapy
monogenic disorder
iPS cells
Roberto Motterlini

INSERM U955, University Paris Est, France

Expertise
Medicine

Research focus
cardiovascular disease
metabolism
pharmacology
inflammation
oxidative stress
heme oxygenase
carbon monoxide
Nicola Napoli

Campus Bio-Medico University of Rome, Italy

Expertise
Medicine

Research focus
endocrinology
metabolism
osteoporosis
bone fragility in diabetic reactions
diabetes
obesity
clinical trials

Experimental organism
human
Anjaparavanda P Naren

Cedars-Sinai Medical Center, United States

Expertise
Medicine
Cell Biology

Research focus
cystic fibrosis
personalized medicine
protein trafficking
protein-protein interactions
macromolecular complexes
CFTR biology
Goutham Narla

University of Michigan, United States

Expertise
Medicine
Cancer Biology
Genetics and Genomics

Research focus
cancer therapeutics
cancer genetics
small molecule drug development
protein phosphatase

Experimental organism
human
mouse
Belinda Nicolau

McGill University, Canada

Expertise
Epidemiology and Global Health
Medicine

Research focus
cancer epidemiology
social determinants of health
Ole Haagen Nielsen

Herlev Hospital, University of Copenhagen, Denmark

Expertise
Medicine

Research focus
gastroenterology (especially inflammatory bowel disease)
internal medicine
Jeremie Nsengimana

Newcastle University, United Kingdom

Expertise
Medicine

Research focus
statistics
genomics
cancer
precision medicine
biomarkers
Renata Pasqualini

Rutgers University, United States

Expertise
Medicine
Cancer Biology

Research focus
radiation oncology
translational cancer research
prostate cancer
vascular biology
David J Paterson

University of Oxford, United Kingdom

Expertise
Medicine
Neuroscience

Research focus
autonomic neuroscience
physiology
cardiac arrhythmias
hypertension
chemoreception
gene therapy
Julian Paton

University of Auckland, New Zealand

Expertise
Medicine
Neuroscience

Research focus
autonomic neuroscience
translational physiology
Luca Pinello

Massachusetts General Hospital, United States

Expertise
Medicine
Computational and Systems Biology
Genetics and Genomics

Research focus
bioinformatics
computational biology
CRISPR genome editing
single-cell genomics
Nelly Pitteloud

CHUV, Switzerland

Expertise
Medicine

Research focus
human genetics
metabolic disorders
insulin resistance
diabetes
Samuel Pleasure

University of California, San Francisco, United States

Expertise
Medicine
Developmental Biology
Neuroscience

Research focus
circuit development
hippocampus
cerebral cortex
epilepsy
human
forebrain development
autoimmune encephalitis
morphogenic signals
mouse
multiple sclerosis
Markus Ploner

Technische Universität München, Germany

Expertise
Neuroscience
Medicine

Research focus
pain
brain
oscillations
synchrony
electroencephalography (EEG)

Experimental organism
human
Serge Przedborski

Columbia University Medical Center, United States

Expertise
Neuroscience
Medicine

Research focus
Parkinson's disease
neurodegeneration
mitochondrial damage
motor neuron disease
amyotrophic lateral sclerosis
astrocytes
autophagy
mitophagy
necroptosis
apoptosis

Experimental organism
human
Matthew A Quinn

Wake Forest School of Medicine, United States

Expertise
Medicine

Research focus
translational liver disease
obesity
women's health
fatty liver
nuclear receptors
reproduction
epigenesis
Peter Ratcliffe

University of Oxford, United Kingdom

Expertise
Cell Biology
Medicine

Research focus
hypoxia
signaling
hypoxia inducible factor
prolyl hydroxylase
oxygenase
cysteine dioxygenase
von Hippel-Landau
N-degron
Michaela Reagan

Maine Medical Center Research Institute, United States

Expertise
Medicine
Cancer Biology
Cell Biology
Stem Cells and Regenerative Medicine

Research focus
multiple myeloma
bone marrow adipocyte
fatty acid binding protein
cancer-induced bone disease
osteolysis

Experimental organism
mouse
Jalees Rehman

University of Illinois at Chicago, United States

Expertise
Cell Biology
Genetics and Genomics
Immunology and Inflammation
Medicine
Stem Cells and Regenerative Medicine

Research focus
vascular biology
macrophage biology
inflammation
transcriptomics
single cell analysis
lung biology
cell regeneration
Martin Reincke

Ludwig-Maximilians-Universität München, Germany

Expertise
Medicine

Research focus
endocrinology
metabolism
endocrine hypertension
adrenal gland function
pituitary-adrenal-axis
pituitary disease
cortisol, stress research
adrenomedullary function
Albert Rizvanov

Kazan Federal University, Russia

Expertise
Medicine

Research focus
stem cells
Isabel Rodriguez-Barraquer

University of California, San Francisco, United States

Expertise
Epidemiology and Global Health
Microbiology and Infectious Disease
Medicine

Research focus
dengue
malaria
Zika
vector-borne diseases
serology
modeling

Experimental organism
human
Antony Rosen

Johns Hopkins University School of Medicine, United States

Expertise
Medicine

Research focus
autoimmunity
autoimmune disease
rheumatic
autoantibodies
granzyme
Gian Paolo Rossi

University of Padua, Italy

Expertise
Medicine

Research focus
arterial hypertension
vascular biology
cardiology
cardiovascular medicine
endocrinology

Experimental organism
human
Maroeska M Rovers

Radboud University Nijmegen, Netherlands

Expertise
Medicine

Research focus
evidence-based surgery
clinical epidemiology
health economics
IPD meta-analysis
Mishaela R Rubin

Columbia University Medical Center, United States

Expertise
Medicine

Research focus
diabetes
parathyroid
osteoporosis
Natalia Rubinstein

University of Buenos Aires-CONICET, Argentina

Expertise
Cancer Biology
Immunology and Inflammation
Medicine
Stem Cells and Regenerative Medicine

Research focus
breast cancer tumor cell
molecular biology
drug resistance
tumor immunology
Juan C Sáez

Universidad de Valparaíso, Chile

Expertise
Neuroscience
Cell Biology
Medicine

Research focus
connexin
pannexin
innexin
neuroinflammation
neuromuscular diseases
Fayez Safadi

Northeast Ohio Medical University, United States

Expertise
Medicine
Stem Cells and Regenerative Medicine

Research focus
biomechanics
Tamer I Sallam

University of California, Los Angeles, United States

Expertise
Medicine
Genetics and Genomics

Research focus
atherosclerosis
lipid metabolism
cardiovascular disease
noncoding RNA
gene regulation
Alan R Saltiel

University of California, San Diego, United States

Expertise
Medicine
Immunology and Inflammation
Cell Biology

Research focus
insulin
action
protein phosphorylation
obesity
metabolism
diabetes
signaling
G proteins
Rebecca M Sappington

Wake Forest School of Medicine, United States

Expertise
Medicine
Neuroscience
Immunology and Inflammation
Developmental Biology

Research focus
retina
optic nerve
neurodegeneration
glia
neuroinflammation
regeneration
axon
cytokine/chemokine
Charles Sawyers

Memorial Sloan-Kettering Cancer Center, United States

Expertise
Cancer Biology
Medicine

Research focus
translational medicine
oncology

Experimental organism
human
Joshua T Schiffer

Fred Hutchinson Cancer Research Center, United States

Expertise
Microbiology and Infectious Disease
Epidemiology and Global Health
Immunology and Inflammation
Medicine

Research focus
mathematical modelling
herpesviruses
HIV
COVID-19
T cell immunology

Experimental organism
human
viruses
HSV
SARS-CoV-2
Nicolas Schlecht

Roswell Park Comprehensive Cancer Center, United States

Expertise
Epidemiology and Global Health
Medicine

Research focus
cancer prevention
cancer control
Nima Sharifi

Cleveland Clinic, United States

Expertise
Biochemistry and Chemical Biology
Cancer Biology
Medicine

Research focus
steroid biochemistry
steroid metabolism
prostate cancer
nuclear receptors
hormone therapy resistance
androgens
oncology

Experimental organism
mouse
Kalyanam Shivkumar

UCLA Health, United States

Expertise
Medicine

Research focus
electrophysiology
neurocardiology
cardiology
neural control
sudden death

Experimental organism
human
mouse
Dolores Shoback

University of California, San Francisco, United States

Expertise
Medicine

Research focus
endocrinology
hormones
bone metabolism
calcium
mineral
parathyroid
vitamin D

Experimental organism
human
mouse
Jawed Siddiqui

University of Nebraska Medical Center, United States

Expertise
Medicine
Cancer Biology

Research focus
bone metastasis
cancer metastasis
chemokines
osteoclasts
osteoblasts
tumor dormancy
therapeutic
Viviana Simon

The Icahn School of Medicine at Mount Sinai, United States

Expertise
Epidemiology and Global Health
Microbiology and Infectious Disease
Medicine

Research focus
viral-host interactions
retroviral restriction factors
HIV drug resistance
Kellie N Smith

Johns Hopkins University School of Medicine, United States

Expertise
Medicine
Immunology and Inflammation

Research focus
cancer immunology
T cells
immunogenomics
T cell receptors
neoantigens
lung cancer
Kumaravel Somasundaram

Indian Institute of Science Bangalore, India

Expertise
Cell Biology
Medicine
Cancer Biology
Genetics and Genomics
Chromosomes and Gene Expression

Research focus
cell signalling
glioma
gene regulation
cancer therapeutics
cancer genomics
cancer stem cells
non-coding RNA
chemoresistance
Renan P Souza

Universidade Federal de Minas Gerais, Brazil

Expertise
Genetics and Genomics
Medicine

Research focus
molecular epidemiology
genomics
biomarkers
statistical modeling
cohort studies
case-control studies
simulation studies
Pramod K Srivastava

UConn Health, United States

Expertise
Medicine
Immunology and Inflammation

Research focus
cancer immunology
tumor antigens
neoantigens
cancer vaccines
immunotherapy
antigen presentation
neoepitopes
cross-presentation

Experimental organism
mouse
human
Jonathan S Stamler

Case Western Reserve University, United States

Expertise
Medicine
Biochemistry and Chemical Biology

Research focus
S-nitrosylation
nitric oxide
redox
redox-signaling
cysteine
thiols
Margaret Stanley

University of Cambridge, United Kingdom

Expertise
Cancer Biology
Microbiology and Infectious Disease
Medicine
Epidemiology and Global Health

Research focus
vaccines
cervix cancer
cervix precancer
keratinocyte biology
human papillomavirus
DNA viruses
vaccine immunology

Experimental organism
human
Larisa Suturina

Scientific Center for Family Health and Human Reproduction, Russia

Expertise
Medicine

Research focus
women's health
infertility
polycystic ovary syndrome (PCOS)
oxidative stress
menopause
obesity
hypothalamic disorders
antioxidants
contraception
POF
adolescent's health
Kiyoshi Takeda

Osaka University, Japan

Expertise
Immunology and Inflammation
Medicine

Research focus
mucosal immunology
inflammatory bowel disease
intestinal immunity
intestinal environmental factors
intestinal epithelial cells
Sakae Tanaka

The University of Tokyo, Japan

Expertise
Medicine

Research focus
bone
osteoporosis
osteoclast
osteoarthritis
rheumatoid arthritis
orthopaedics
Rudolph E Tanzi

Harvard University, United States

Expertise
Neuroscience
Genetics and Genomics
Medicine

Research focus
Alzheimer's disease
genetics
neurodegenerative disease
amyloid
neuroinflammation

Experimental organism
mouse
human
brain organoids
Mauro M Teixeira

Universidade Federal de Minas Gerais, Brazil

Expertise
Medicine
Immunology and Inflammation
Microbiology and Infectious Disease

Research focus
inflammation
mediators of inflammation
pharmacology
anti-viral compounds
arboviral infections
clinical trials
Carmen D Tekwe

Indiana University Bloomington, United States

Expertise
Medicine

Research focus
biostatistics
dietary intake
physical activity behavior
Aseem Prakash Tikku

King George's Medical University, India

Expertise
Medicine

Research focus
dentistry
endodontics
Peter Tontonoz

University of California, Los Angeles, United States

Expertise
Cell Biology
Medicine

Research focus
lipid metabolism
cholesterol
nuclear receptors
adipocytes
obesity
atherosclerosis
diabetes

Experimental organism
mouse
Ritu Trivedi

CSIR-Central Drug Research Institute, India

Expertise
Medicine

Research focus
drug development
animal models of endocrine diseases
Farah Usmani

United Nations Population Fund (UNFPA), United States

Expertise
Medicine

Research focus
health policy
reproductive health
reproductive rights
Frank van de Veerdonk

Radboud University Medical Center, Netherlands

Expertise
Immunology and Inflammation
Microbiology and Infectious Disease
Medicine

Research focus
medical mycology
clinical immunology
Amit Verma

Albert Einstein College of Medicine, United States

Expertise
Medicine
Cancer Biology

Research focus
leukemia
cancer stem cells
myelodysplasia
clonal hematopoiesis
Mei Wan

Johns Hopkins University School of Medicine, United States

Expertise
Medicine
Cell Biology

Research focus
bone remodeling
osteoarthritis
osteoblasts
osteoclast
cellular senescence
mesenchymal stem cells
progenitor cells
Linghua Wang

The University of Texas MD Anderson Cancer Center, United States

Expertise
Cancer Biology
Computational and Systems Biology
Genetics and Genomics
Immunology and Inflammation
Medicine

Research focus
computational biology
cancer immunogenomics
cancer genomics
Tracey L Weissgerber

Berlin Institute of Health (BIH) at Charité, Germany

Expertise
Medicine

Research focus
data visualization
statistical analysis
reproducibility
meta-research
open and reproducible methods
systematic review
scientific rigor
transparency
automated screening
Christopher S Williams

Vanderbilt University, United States

Expertise
Medicine

Research focus
gastroenterology
GI track cancer
murine
inflammatory bowel disease
Wei Yan

University of California, Los Angeles, United States

Expertise
Developmental Biology
Genetics and Genomics
Medicine

Research focus
fertility
germ cells
reproduction
epigenetic inheritance
epigenomics
noncoding RNAs
post-transcriptional regulation
Qifeng Yang

Qilu Hospital of Shandong University, China

Expertise
Medicine
Cancer Biology

Research focus
breast cancer
cancer stem cells
metastasis
cancer associated fibroblasts
chemoresistance
Yongliang Yang

Dalian University of Technology, China

Expertise
Medicine
Cancer Biology
Computational and Systems Biology

Research focus
bioinformatics
computational biology
drug discovery
artificial intelligence
Yunlei Yang

Albert Einstein College of Medicine, United States

Expertise
Medicine
Neuroscience

Research focus
glia
neural circuits
anxiety
diabetes
obesity
neuron
Keqiang Ye

Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, China

Expertise
Medicine
Cancer Biology
Biochemistry and Chemical Biology
Neuroscience

Research focus
neuroscience
molecular cytobiology
cancer biology
neurodegenerative disease

Experimental organism
mouse
Tony Yuen

Icahn School of Medicine at Mount Sinai, United States

Expertise
Medicine

Research focus
genetics of rare diseases
prenatal diagnosis
Mark L Zeidel

Beth Israel Deaconess Medical Center, United States

Expertise
Medicine

Research focus
kidney disease
bladder disease
Baohong Zhao

Hospital for Special Surgery, United States

Expertise
Medicine
Cell Biology

Research focus
osteoclast
osteoimmunology
bone
TNF

Experimental organism
mouse
Siming Zhao

Dartmouth College, United States

Expertise
Medicine
Computational and Systems Biology
Genetics and Genomics

Research focus
statistical genetics
genomics
human genetics
sequencing data
Shengtao Zhou

Sichuan University West China Second University Hospital, China

Expertise
Cancer Biology
Medicine

Research focus
gynecologic oncology
cancer biology
tumor immunology
metabolism
nuclear receptors
systems biology

Experimental organism
human
mouse
Hao Zhu

University of Texas Southwestern Medical Center, United States

Expertise
Cancer Biology
Stem Cells and Regenerative Medicine
Medicine

Research focus
mechanisms of tissue repair and organ regeneration
liver cancer
hepatocellular carcinoma
epigenetics
polyploidy

Experimental organism
human
mouse
Bian Zhuan

Wuhan University, China

Expertise
Medicine
Genetics and Genomics

Research focus
craniofacial genetics
oral and craniofacial developmental defects
orofacial clefts
tooth agenesis
Roger S Zoh

Indiana University Bloomington, United States

Expertise
Medicine

Research focus
Bayesian statistical methods