Medicine

Latest articles

1. 1. Medicine

   Science Forum: Improving preclinical studies through replications

   Natascha Ingrid Drude et al.

   Increasing validity should be a priority when deciding which preclinical experiments to replicate and when performing replications.
2. 1. Immunology and Inflammation
   2. Medicine

   The orchestrated cellular and molecular responses of the kidney to endotoxin define a precise sepsis timeline

   Danielle Janosevic et al.

   Single-cell RNA-sequencing identifies the precise cellular and molecular events that occur along the sepsis timeline in the kidney, pointing to potential biomarkers and therapeutic targets.
3. 1. Computational and Systems Biology
   2. Medicine

   Reproducible analysis of disease space via principal components using the novel R package syndRomics

   Abel Torres Espín et al.
4. 1. Immunology and Inflammation
   2. Medicine

   Cytokine ranking via mutual information algorithm correlates cytokine profiles with presenting disease severity in patients infected with SARS-CoV-2

   Kelsey E Huntington et al.
5. 1. Medicine

   The gut microbiota is a transmissible determinant of skeletal maturation

   Abdul Malik Tyagi et al.

   The gut microbiota is a non-genomic, transmissible regulator of bone volume, structure, and turnover.
6. 1. Immunology and Inflammation
   2. Medicine

   Methotrexate attenuates vascular inflammation through an adenosine-microRNA dependent pathway

   Dafeng Yang et al.
7. 1. Evolutionary Biology
   2. Medicine

   Developing a theoretical evolutionary framework to solve the mystery of parturition initiation

   Antonis Rokas et al.

   This review considers the evolutionary processes and physiological mechanisms that maintain or end pregnancy in mammals to formulate general, testable theoretical models that provide insights into the biology of parturition.
8. 1. Cell Biology
   2. Medicine

   Remodeling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division

   Jin Rong Ow et al.

   Loss of hepatic Cdk1 leads to oxidative stress, increased fatty acids in blood, and hyperinsulinemia, which resulted in insulin resistance and hepatic steatosis, similar as in diabetes.
9. 1. Cell Biology
   2. Medicine

   Def6 regulates endogenous type-I interferon responses in osteoblasts and suppresses osteogenesis

   Zhonghao Deng et al.

   Def6 functions as a novel immunoregulator in bone cells via endogenous type-I interferon response to regulate bone remodeling.
10. 1. Cell Biology
    2. Medicine

    An AMPK-dependent, non-canonical p53 pathway plays a key role in adipocyte metabolic reprogramming

    Hong Wang et al.

    A non-canonical p53 function in adipocyte plays a critical role in energy homeostasis and is involved in obesity-associated metabolic dysfunctions.