Medicine

Latest articles

1. 1. Immunology and Inflammation
   2. Medicine

   Mucosal-associated invariant T (MAIT) cells mediate protective host responses in sepsis

   Shubhanshi Trivedi et al.

   Mucosal-associated invariant T (MAIT) cells, highly activated and dysfunctional in sepsis patients, contribute to tissue-specific cytokine responses that are protective against mortality during experimental sepsis.
2. 1. Cell Biology
   2. Medicine

   Lymphangiogenic therapy prevents cardiac dysfunction by ameliorating inflammation and hypertension

   LouJin Song et al.
3. 1. Medicine

   Reprogramming of bone marrow myeloid progenitor cells in patients with severe coronary artery disease

   Marlies P Noz et al.

   In patients with coronary artery disease, bone marrow myeloid progenitor cells are reprogrammed towards myeloid skewing and inflammatory activation.
4. 1. Medicine

   Weight loss, insulin resistance, and study design confound results in a meta-analysis of animal models of fatty liver

   Harriet Hunter et al.

   Animal studies of fatty liver disease over-estimate the benefit of drugs due to publication bias and are confounded by off-target weight loss, illustrating the challenge of successful translational across species.
5. 1. Medicine
   2. Microbiology and Infectious Disease

   Early prediction of level-of-care requirements in patients with COVID-19

   Boran Hao et al.

   Using data for 2566 COVID-19 patients from five hospitals, models are developed to predict for each patient hospitalization and critical care needs, based on demographics, comorbidities, medications, and laboratory findings.
6. 1. Medicine

   Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix

   Danae E Zamboulis et al.

   Phase-specific mechanical and proteomic analyses reveal how tendon responds to its mechanical environment during postnatal development to meet functional requirements.
7. 1. Genetics and Genomics
   2. Medicine

   Effects of lifelong testosterone exposure on health and disease using Mendelian randomization

   Pedrum Mohammadi-Shemirani et al.

   Long-term increased testosterone improved body composition and bone density, but lowered HDL and raised risks of hypertension, androgenic alopecia, prostate cancer, and spinal stenosis in males.
8. 1. Medicine
   2. Neuroscience

   APOE2 is associated with longevity independent of Alzheimer’s disease

   Mitsuru Shinohara et al.

   Translational evidence indicates APOE2 benefits longevity independent of its protective effects on Alzheimer’s disease, which preserved activity and the metabolism of apoE protein and associated-lipids would be key to understanding.
9. 1. Genetics and Genomics
   2. Medicine

   Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome

   Jeanne L Theis et al.

   Hypoplastic left heart syndrome is reflected by reduced proliferative capacity of patient iPSC-derived cardiomyocytes and requires the activity of LRP2/APOB proteins, likely in conjunction with SHH and WNT signaling pathways.
10. 1. Medicine
    2. Neuroscience

    Parkinson’s Disease: Debunking an old theory

    Teresa Spix, Aryn Gittis

    Recording the neural activity of cells in the brain of patients with Parkinson's disease challenges long-standing assumptions about how this disease manifests at the cellular level.