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Latest articles

    1. Evolutionary Biology
    2. Medicine

    Evolution-based mathematical models significantly prolong response to abiraterone in metastatic castrate-resistant prostate cancer and identify strategies to further improve outcomes

    Jingsong Zhang et al.
    Integration of evolutionary dynamics framed through a mathematical model improved outcomes in abiraterone monotherapy for the treatment of metastatic castrate-resistant prostate cancer.
    1. Medicine

    US women screen at low rates for both cervical and colorectal cancers than a single cancer: a cross-sectional population-based observational study

    Diane M Harper et al.
    Only about half of women 50–64 years old are up-to-date for both cervical and colorectal cancer screening.
    1. Cell Biology
    2. Medicine

    SNTA1 gene rescues ion channel function and is antiarrhythmic in cardiomyocytes derived from induced pluripotent stem cells from muscular dystrophy patients

    Eric N Jimenez-Vazquez et al.
    Important mechanistic details on Duchenne Muscular Dystrophy arrhythmogenesis are revealed, providing a crucial lead for investigators interested in developing therapeutic solutions for this deadly disease.
    1. Medicine
    2. Neuroscience

    Altered excitatory and inhibitory neuronal subpopulation parameters are distinctly associated with tau and amyloid in Alzheimer’s disease

    Kamalini G Ranasinghe et al.
    Excitatory and inhibitory neuronal abnormalities show distinct associations to tau and amyloid accumulations in patients with Alzheimer’s disease.
    1. Genetics and Genomics
    2. Medicine

    A genome-wide functional genomics approach uncovers genetic determinants of immune phenotypes in type 1 diabetes

    Xiaojing Chu et al.
    Deep immunophenotyping characterizes the genetic factors influencing immune functionality in patients with type 1 diabetes.
    1. Medicine
    2. Neuroscience

    Lead-OR: A multimodal platform for deep brain stimulation surgery

    Simón Oxenford et al.
    Lead-OR visualizes results derived from microelectrode recordings in anatomical space, together with information derived from patient-specific MRI data, as well as high-resolution atlas resources during deep brain stimulation surgery.
    1. Cell Biology
    2. Medicine

    Inhibition of the sodium-dependent HCO3- transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype

    Vinciane Saint-Criq et al.
    The reduction of bicarbonate secretion into the airways reproduces cystic fibrosis-like features, independently of chloride secretion.
    1. Medicine
    2. Neuroscience

    Multi-tract multi-symptom relationships in pediatric concussion

    Guido I Guberman et al.
    In paediatric concussions, there are a multiplicity of ways that brain damage gives rise to symptoms, most of which are missed by conventional statistical approaches and study designs.
    1. Epidemiology and Global Health
    2. Medicine

    Type 2 diabetes mellitus accelerates brain aging and cognitive decline: Complementary findings from UK Biobank and meta-analyses

    Botond Antal et al.
    Patients with Type 2 diabetes show patterns of neurodegeneration consistent with accelerated brain aging, including impaired cognition and loss of brain volume, which are more severe in those with increased disease duration.
    1. Computational and Systems Biology
    2. Medicine

    Development and evaluation of a machine learning-based in-hospital COVID-19 disease outcome predictor (CODOP): A multicontinental retrospective study

    Riku Klén et al.
    The generalizability of CODOP in distinct world regions and its flexibility to reckon with the changing availability of hospital resources makes it a clinically useful tool potentially improving the outcome prediction and the management of COVID-19 hospitalized patients.

Senior editors

  1. Ricardo Azziz
    University at Albany, SUNY, United States
  2. Matthias Barton
    University of Zurich, Switzerland
  3. Balram Bhargava
    Indian Council of Medical Research, India
  4. See more editors