Medicine

Latest articles

1. 1. Medicine

   Dysregulation of the PRUNE2/PCA3 genetic axis in human prostate cancer: from experimental discovery to validation in two independent patient cohorts

   Richard C Lauer, Marc Barry ... Wadih Arap

   PRUNE2/PCA3 axis dysregulation is an early, rather than late, event in prostate cancer tumorigenesis.
2. 1. Cancer Biology
   2. Medicine

   International multicenter study comparing COVID-19 in patients with cancer to patients without cancer: impact of risk factors and treatment modalities on survivorship

   Issam I Raad, Ray Hachem ... Anne-Marie Chaftari
3. 1. Medicine

   Phenome-wide Mendelian randomisation analysis identifies causal factors for age-related macular degeneration

   Thomas H Julian, Johnathan Cooper-Knock ... Panagiotis I Sergouniotis

   A phenome-wide Mendelian randomisation analysis revealed a causal link between age-related macular degeneration and a number of lipid, complement, immune cell, and serum protein traits, highlighting potential treatment targets.
4. 1. Cell Biology
   2. Medicine

   Efficacy and safety of metabolic interventions for the treatment of severe COVID-19: in vitro, observational, and non-randomized open label interventional study

   Avner Ehrlich, Konstantinos Ioannidis ... Yaakov Nahmias
5. 1. Medicine

   Tenotomy-induced muscle atrophy is sex-specific and independent of NFκB

   Gretchen A Meyer, Stavros Thomopoulos ... Karen C Shen

   Blocking an atrophic 'master regulator' pathway following tendon tear does not affect resulting skeletal muscle atrophy.
6. 1. Medicine

   Single-cell RNA sequencing and lineage tracing confirm mesenchyme to epithelial transformation (MET) contributes to repair of the endometrium at menstruation

   Phoebe M Kirkwood, Douglas A Gibson ... Philippa TK Saunders

   In a mouse model of menstruation stromal cells respond to breakdown of the tissue by changing their identity to become epithelial cells that are incorporated into the luminal epithelium which is rapidly 'healed' without scarring.
7. 1. Epidemiology and Global Health
   2. Medicine

   Antibody levels following vaccination against SARS-CoV-2: associations with post-vaccination infection and risk factors in two UK longitudinal studies

   Nathan J Cheetham, Milla Kibble ... Claire J Steves
8. 1. Medicine
   2. Microbiology and Infectious Disease

   Efficacy of ultra-short, response-guided sofosbuvir and daclatasvir therapy for hepatitis C in a single-arm mechanistic pilot study

   Barnaby Flower, Le Manh Hung ... Graham S Cooke

   Shortened hepatitis C therapy, with retreatment if needed, can reduce antiviral drug use in patients with mild liver disease, but day 2 viral load is not an adequate predictor of outcome.
9. 1. Medicine

   Bone circuitry and interorgan skeletal crosstalk

   Mone Zaidi, Se-Min Kim ... Tony Yuen

   Intracellular and interorgan skeletal crosstalk highlights integrative skeletal physiology.
10. 1. Medicine

    Selective androgen receptor degrader (SARD) to overcome antiandrogen resistance in castration-resistant prostate cancer

    Meng Wu, Rongyu Zhang ... Jinming Zhou