Medicine

Medicine

eLife publishes translational, clinical and health policy research in all areas of medicine. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Medicine

    Mechanisms underlying neonate-specific metabolic effects of volatile anesthetics

    Julia Stokes et al.
    Volatile anesthetics impair hepatic tricarboxylic acid cycle function in adult and neonatal mice, with citrate accumulation driving a neonate-specific inhibition of beta-oxidation and ketosis through their increased relative sensitivity to malonyl-CoA.
    1. Medicine

    7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis

    Fan Xue et al.
    In vitro and in vivo studies highlight the dual regulatory effects that 7,8-dihydroxyflavone exerts on bone formation and resorption.
    1. Medicine
    2. Microbiology and Infectious Disease

    Ct threshold values, a proxy for viral load in community SARS-CoV-2 cases, demonstrate wide variation across populations and over time

    A Sarah Walker et al.
    Wide variation in cycle threshold (Ct) values from SARS-CoV-2 RT-PCR tests over calendar time offers the potential for their broader use in public testing programmes as an ‘early-warning’ system for shifts in infectious load and hence transmission.
    1. Epidemiology and Global Health
    2. Medicine

    Impact of COVID-19-related disruptions to measles, meningococcal A, and yellow fever vaccination in 10 countries

    Katy AM Gaythorpe et al.
    Routine and campaign vaccination disruption in 2020 may lead to measles outbreaks and yellow fever burden increases in some countries, but is unlikely to greatly increase meningococcal A burden.
    1. Medicine
    2. Neuroscience

    Two de novo GluN2B mutations affect multiple NMDAR-functions and instigate severe pediatric encephalopathy

    Shai Kellner et al.
    Two novel mutations in the GRIN2B gene reduce glutamate affinity by >1000-fold, reduce the receptors proton-sensitivity, and exert a dominant-negative effect over receptors in neurons.
    1. Medicine

    Restored TDCA and valine levels imitate the effects of bariatric surgery

    Markus Quante et al.
    Restored taurodeoxycholic acid and valine levels imitate the effects of bariatric surgery on weight loss and obesity-related disorders.
    1. Immunology and Inflammation
    2. Medicine

    Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2

    Dongjin Jeong et al.
    Soluble Fas ligand interacts specifically with tumor necrosis factor receptor superfamily (TNFRSF)10B, also known as death receptor 5, exacerbating arthritis in a Fas-independent manner.
    1. Medicine

    Hepatoenteric recycling is a new disposition mechanism for orally administered phenolic drugs and phytochemicals in rats

    Yifan Tu et al.
    A new disposition mechanism for glucuronides, where liver serves as recycle organ and intestine serves as metabolism organ, is established to better explain the disposition of phenolics in vivo.
    1. Cell Biology
    2. Medicine

    The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy

    Yang Guo et al.
    The TRPM4 ion channel has been identified as an important component in the causation of mechanical pressure overload-induced pathological left ventricular hypertrophy, which is a powerful predictor of cardiovascular mortality.

Senior editors

  1. Miles P Davenport
    University of New South Wales, Australia
  2. Wendy S Garrett
    Wendy S Garrett
    Harvard T.H. Chan School of Public Health, United States
  3. Richard M White
    Memorial Sloan Kettering Cancer Center, United States
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