Medicine

Latest articles

1. 1. Immunology and Inflammation
   2. Medicine

   Expansion of CD10^neg neutrophils and HLA-DR^neg/low monocytes driving inflammatory responses after myocardial infarction

   Daniela Fraccarollo et al.
2. 1. Medicine

   Mechanisms underlying neonate-specific metabolic effects of volatile anesthetics

   Julia Stokes et al.

   Volatile anesthetics impair hepatic tricarboxylic acid cycle function in adult and neonatal mice, with citrate accumulation driving a neonate-specific inhibition of beta-oxidation and ketosis through their increased relative sensitivity to malonyl-CoA.
3. 1. Medicine

   7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis

   Fan Xue et al.

   In vitro and in vivo studies highlight the dual regulatory effects that 7,8-dihydroxyflavone exerts on bone formation and resorption.
4. 1. Medicine
   2. Microbiology and Infectious Disease

   Ct threshold values, a proxy for viral load in community SARS-CoV-2 cases, demonstrate wide variation across populations and over time

   A Sarah Walker et al.

   Wide variation in cycle threshold (Ct) values from SARS-CoV-2 RT-PCR tests over calendar time offers the potential for their broader use in public testing programmes as an ‘early-warning’ system for shifts in infectious load and hence transmission.
5. 1. Epidemiology and Global Health
   2. Medicine

   Impact of COVID-19-related disruptions to measles, meningococcal A, and yellow fever vaccination in 10 countries

   Katy AM Gaythorpe et al.

   Routine and campaign vaccination disruption in 2020 may lead to measles outbreaks and yellow fever burden increases in some countries, but is unlikely to greatly increase meningococcal A burden.
6. 1. Medicine
   2. Neuroscience

   Two de novo GluN2B mutations affect multiple NMDAR-functions and instigate severe pediatric encephalopathy

   Shai Kellner et al.

   Two novel mutations in the GRIN2B gene reduce glutamate affinity by >1000-fold, reduce the receptors proton-sensitivity, and exert a dominant-negative effect over receptors in neurons.
7. 1. Medicine

   Restored TDCA and valine levels imitate the effects of bariatric surgery

   Markus Quante et al.

   Restored taurodeoxycholic acid and valine levels imitate the effects of bariatric surgery on weight loss and obesity-related disorders.
8. 1. Immunology and Inflammation
   2. Medicine

   Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2

   Dongjin Jeong et al.

   Soluble Fas ligand interacts specifically with tumor necrosis factor receptor superfamily (TNFRSF)10B, also known as death receptor 5, exacerbating arthritis in a Fas-independent manner.
9. 1. Medicine

   Hepatoenteric recycling is a new disposition mechanism for orally administered phenolic drugs and phytochemicals in rats

   Yifan Tu et al.

   A new disposition mechanism for glucuronides, where liver serves as recycle organ and intestine serves as metabolism organ, is established to better explain the disposition of phenolics in vivo.
10. 1. Cell Biology
    2. Medicine

    The Ca²⁺-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy

    Yang Guo et al.

    The TRPM4 ion channel has been identified as an important component in the causation of mechanical pressure overload-induced pathological left ventricular hypertrophy, which is a powerful predictor of cardiovascular mortality.