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Latest articles

    1. Medicine

    Dysregulation of the PRUNE2/PCA3 genetic axis in human prostate cancer: from experimental discovery to validation in two independent patient cohorts

    Richard C Lauer, Marc Barry ... Wadih Arap
    PRUNE2/PCA3 axis dysregulation is an early, rather than late, event in prostate cancer tumorigenesis.
    1. Medicine

    Phenome-wide Mendelian randomisation analysis identifies causal factors for age-related macular degeneration

    Thomas H Julian, Johnathan Cooper-Knock ... Panagiotis I Sergouniotis
    A phenome-wide Mendelian randomisation analysis revealed a causal link between age-related macular degeneration and a number of lipid, complement, immune cell, and serum protein traits, highlighting potential treatment targets.
    1. Medicine

    Tenotomy-induced muscle atrophy is sex-specific and independent of NFκB

    Gretchen A Meyer, Stavros Thomopoulos ... Karen C Shen
    Blocking an atrophic 'master regulator' pathway following tendon tear does not affect resulting skeletal muscle atrophy.
    1. Medicine

    Single-cell RNA sequencing and lineage tracing confirm mesenchyme to epithelial transformation (MET) contributes to repair of the endometrium at menstruation

    Phoebe M Kirkwood, Douglas A Gibson ... Philippa TK Saunders
    In a mouse model of menstruation stromal cells respond to breakdown of the tissue by changing their identity to become epithelial cells that are incorporated into the luminal epithelium which is rapidly 'healed' without scarring.
    1. Medicine
    2. Microbiology and Infectious Disease

    Efficacy of ultra-short, response-guided sofosbuvir and daclatasvir therapy for hepatitis C in a single-arm mechanistic pilot study

    Barnaby Flower, Le Manh Hung ... Graham S Cooke
    Shortened hepatitis C therapy, with retreatment if needed, can reduce antiviral drug use in patients with mild liver disease, but day 2 viral load is not an adequate predictor of outcome.
    1. Medicine

    Bone circuitry and interorgan skeletal crosstalk

    Mone Zaidi, Se-Min Kim ... Tony Yuen
    Intracellular and interorgan skeletal crosstalk highlights integrative skeletal physiology.

Senior editors

  1. Miles P Davenport
    University of New South Wales, Australia
  2. Martin Pollak
    Harvard Medical School, United States
  3. Ma-Li Wong
    State University of New York Upstate Medical University, United States
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