Medicine

Latest articles

1. 1. Medicine
   2. Neuroscience

   Altered excitatory and inhibitory neuronal subpopulation parameters are distinctly associated with tau and amyloid in Alzheimer's disease

   Kamalini Ranasinghe et al.
2. 1. Medicine
   2. Neuroscience

   Multi-tract multi-symptom relationships in pediatric concussion

   Guido I Guberman et al.

   In paediatric concussions, there are a multiplicity of ways that brain damage gives rise to symptoms, most of which are missed by conventional statistical approaches and study designs.
3. 1. Epidemiology and Global Health
   2. Medicine

   Type 2 diabetes mellitus accelerates brain aging and cognitive decline: Complementary findings from UK Biobank and meta-analyses

   Botond Antal et al.

   Patients with Type 2 diabetes show patterns of neurodegeneration consistent with accelerated brain aging, including impaired cognition and loss of brain volume, which are more severe in those with increased disease duration.
4. 1. Computational and Systems Biology
   2. Medicine

   Development and evaluation of a machine learning-based in-hospital COVID-19 disease outcome predictor (CODOP): A multicontinental retrospective study

   Riku Klén et al.

   The generalizability of CODOP in distinct world regions and its flexibility to reckon with the changing availability of hospital resources makes it a clinically useful tool potentially improving the outcome prediction and the management of COVID-19 hospitalized patients.
5. 1. Immunology and Inflammation
   2. Medicine

   The DNA sensors AIM2 and IFI16 are SLE autoantigens that bind neutrophil extracellular traps

   Brendan Antiochos et al.

   A novel extracellular role for cytoplasmic DNA sensors in shielding NET DNA from DNase-mediated degradation.
6. 1. Medicine

   Migraine monoclonal antibodies against CGRP change brain activity depending on ligand or receptor target – an fMRI study

   Hauke Basedau et al.

   Despite relative impermeability of the blood-brain barrier for calcitonin gene-related peptide antibodies used in migraine treatment, these antibodies induce certain and highly specific brain effects particularly in the hypothalamus which may be part of the mechanism of their efficacy.
7. 1. Medicine
   2. Neuroscience

   Lead-OR: a multimodal platform for deep brain stimulation surgery

   Simon Oxenford et al.
8. 1. Medicine
   2. Physics of Living Systems

   Synchronization in renal microcirculation unveiled with high-resolution blood flow imaging

   Dmitry Postnov et al.

   High-resolution blood flow imaging confirms the presence of large, long-living synchronous clusters in renal microcirculation and reveals how vasoactive drugs affect synchronization properties.
9. 1. Developmental Biology
   2. Medicine

   VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development

   Derek C Sung et al.

   VE-cadherin is required for trophoblast invasion of the maternal decidua and spiral arteries.
10. 1. Medicine

    Utility of estimated pulse wave velocity for assessing vascular stiffness: comparison of methods

    Stefan Möstl et al.

    Novel blood pressure devices provide an estimated pulse wave velocity, which is no substitute for measured pulse wave velocity and clinicians should be aware that it only reflects trends derived from representative population samples based on age and blood pressure.