Medicine

Latest articles

1. 1. Medicine

   Study of efficacy and longevity of immune response to 3^rd and 4^th doses of COVID-19 vaccines in patients with cancer: a single arm clinical trial

   Astha Thakkar, Kith Pradhan ... Balazs Halmos
2. 1. Medicine
   2. Neuroscience

   The role of expectations, control and reward in the development of pain persistence based on a unified model

   Christian Büchel

   The integration of established psychological and biological models of pain suggests novel interventions to prevent pain persistence.
3. 1. Cancer Biology
   2. Medicine

   A survey of open questions in adaptive therapy: Bridging mathematics and clinical translation

   Jeffrey West, Fred Adler ... Alexander RA Anderson

   Open questions of cancer adaptive therapy are discussed through the lens of mathematical modeling, categorized into three sections, (1) integrating appropriate components into mathematical models, (2) dosing protocol design and validation, and (3) challenges and opportunities in clinical translation.
4. 1. Biochemistry and Chemical Biology
   2. Medicine

   Iron status influences mitochondrial disease progression in Complex I-deficient mice

   CJ Kelly, Reid K Couch ... Anthony S Grillo

   In vivo studies reveal that mitochondrial Complex I deficiencies induce iron misregulation and liver iron overload that may contribute to neurodegeneration in mitochondrial disease mice, and that iron restriction is effective in reducing disease progression.
5. 1. Medicine

   Cardiac electrophysiological remodeling associated with enhanced arrhythmia susceptibility in a canine model of elite exercise

   Alexandra Polyák, Leila Topal ... András Varró

   Vigorous endurance training results in prolongation of cardiac repolarization and increased repolarization instability, mild ventricular fibrosis associated with decrease of the transient outward potassium current, and enhanced arrhythmia susceptibility in canine model.
6. 1. Medicine

   An herbal drug combination identified by knowledge graph alleviates the clinical symptoms of plasma cell mastitis patients: a nonrandomized controlled trial

   Caigang Liu, Hong Yu ... Yongliang Yang
7. 1. Medicine
   2. Immunology and Inflammation

   Bone marrow Adipoq-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis, and bone mass

   Kazuki Inoue, Yongli Qin ... Baohong Zhao

   Identification of bone marrow Adipoq-lineage progenitors as a novel and major cellular source of M-CSF in mice and humans, which controls bone marrow macrophage development, osteoclastogenesis, and bone mass in physiological and pathological conditions.
8. 1. Cell Biology
   2. Medicine

   Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone

   Leilei Zhong, Jiawei Lu ... Ling Qin

   Bone marrow adipogenic precursors synthesize Csf1 to control bone remodeling and hematopoiesis.
9. 1. Medicine
   2. Neuroscience

   Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsy

   Pablo Miguel Casillas-Espinosa, Alison Anderson ... Terence J O’Brien
10. 1. Epidemiology and Global Health
    2. Medicine

    A systematic assessment of preclinical multilaboratory studies and a comparison to single laboratory studies

    Victoria T Hunniford, Agnes Grudniewicz ... Manoj M Lalu