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Latest articles

    1. Medicine

    An herbal drug combination identified by knowledge graph alleviates the clinical symptoms of plasma cell mastitis patients: A nonrandomized controlled trial

    Caigang Liu, Hong Yu ... Yongliang Yang
    Knowledge graph identified an herbal drug combination for the treatment of plasma cell mastitis.
    1. Medicine
    2. Neuroscience

    The role of expectations, control and reward in the development of pain persistence based on a unified model

    Christian Büchel
    The integration of established psychological and biological models of pain suggests novel interventions to prevent pain persistence.
    1. Cancer Biology
    2. Medicine

    A survey of open questions in adaptive therapy: Bridging mathematics and clinical translation

    Jeffrey West, Fred Adler ... Alexander RA Anderson
    Open questions of cancer adaptive therapy are discussed through the lens of mathematical modeling, categorized into three sections, (1) integrating appropriate components into mathematical models, (2) dosing protocol design and validation, and (3) challenges and opportunities in clinical translation.
    1. Biochemistry and Chemical Biology
    2. Medicine

    Iron status influences mitochondrial disease progression in Complex I-deficient mice

    CJ Kelly, Reid K Couch ... Anthony S Grillo
    In vivo studies reveal that mitochondrial Complex I deficiencies induce iron misregulation and liver iron overload that may contribute to neurodegeneration in mitochondrial disease mice, and that iron restriction is effective in reducing disease progression.
    1. Medicine

    Cardiac electrophysiological remodeling associated with enhanced arrhythmia susceptibility in a canine model of elite exercise

    Alexandra Polyák, Leila Topal ... András Varró
    Vigorous endurance training results in prolongation of cardiac repolarization and increased repolarization instability, mild ventricular fibrosis associated with decrease of the transient outward potassium current, and enhanced arrhythmia susceptibility in canine model.
    1. Medicine
    2. Immunology and Inflammation

    Bone marrow Adipoq-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis, and bone mass

    Kazuki Inoue, Yongli Qin ... Baohong Zhao
    Identification of bone marrow Adipoq-lineage progenitors as a novel and major cellular source of M-CSF in mice and humans, which controls bone marrow macrophage development, osteoclastogenesis, and bone mass in physiological and pathological conditions.
    1. Cell Biology
    2. Medicine

    Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone

    Leilei Zhong, Jiawei Lu ... Ling Qin
    Bone marrow adipogenic precursors synthesize Csf1 to control bone remodeling and hematopoiesis.
    1. Medicine
    2. Neuroscience

    Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsy

    Pablo Miguel Casillas-Espinosa, Alison Anderson ... Terence J O’Brien

Senior editors

  1. Olujimi A Ajijola
    University of California, Los Angeles, United States
  2. Matthias Barton
    University of Zurich, Switzerland
  3. Tony Ng
    King's College London, United Kingdom
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