Medicine

Medicine

eLife reviews translational, clinical and health policy research in all areas of medicine. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Medicine

    Gamma Knife Stereotactic radiotherapy combined with tislelizumab as later-line therapy in hpMMR/MSS/MSI-L metastatic colorectal cancer: A Phase II Trial Analysis

    Yiran Zhang, Hanyang Guan ... Jinghua Pan
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Medicine
    2. Neuroscience

    mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance

    Philip Stavrides, Chris N Goulbourne ... Dun-Sheng Yang
    ALP alterations in Q175 brains are late-onset, mild, existing at the later phases of the pathway, and stimulating autophagy at early disease progression enhances mHTT clearance to ameliorate HD pathology.
    1. Cell Biology
    2. Medicine

    Endometriosis is not the endometrium: Reviewing the over-representation of eutopic endometrium in endometriosis research

    Kate Gunther, Teagan Fisher ... Caroline Elizabeth Ford
    Nearly half of sequencing data labeled as endometriosis lacks true disease representation, highlighting the urgent need for more diverse and accurate tissue sampling to advance research in this underrepresented field.
    1. Cell Biology
    2. Medicine

    AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism

    Zongwang Zhang, Lixia Zheng ... Jing-Wei Xiong
    AARS2 safeguards cardiomyocytes against ischemic injury by modulating PKM2-driven energy metabolism, revealing the AARS2-PKM2 axis as a previously unrecognized cardioprotective pathway in myocardial infarction.
    1. Medicine

    Transparency of research practices in cardiovascular literature

    Gabriel O Heckerman, Eileen Tzng ... Adrienne Mueller
    Based on a standardized screening process, the simple majority of reviewed cardiovascular research publications lack sufficient information needed for the study to be replicated or reproduced.
    1. Medicine
    2. Epidemiology and Global Health

    Five-Year Survival Outcomes for Breast Cancer Patients Across Continental Africa: A Contemporary Review of Literature with Meta Analysis

    Augustina Badu-Peprah, Ernest Kissi Kontor ... Nityanand Jain
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Medicine
    2. Microbiology and Infectious Disease

    HERV activation segregates ME/CFS from fibromyalgia while defining a novel nosologic entity

    Karen Giménez-Orenga, Eva Martín-Martínez ... Elisa Oltra
    Transcriptomic profiling of HERV elements at the loci level differentiates ME/CFS, fibromyalgia, and their overlap, revealing distinct immuno-epigenetic landscapes.
    1. Medicine

    Characterisation and comparison of semen microbiota and bacterial load in men with infertility, recurrent miscarriage, or proven fertility

    Shahriar Mowla, Linda Farahani ... Channa N Jayasena
    There are common seminal microbiome clusters in both healthy men and those with infertility and recurrent pregnancy loss, and some specific microbiota perturbations are associated with impaired semen quality.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Magnetically steered cell therapy for reduction of intraocular pressure as a treatment strategy for open-angle glaucoma

    M Reza Bahrani Fard, Jessica Chan ... C Ross Ethier
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling

Senior editors

  1. Matthias Barton
    University of Zurich, Switzerland
  2. Christian Büchel
    University Medical Center Hamburg-Eppendorf, Germany
  3. Christopher L-H Huang
    University of Cambridge, United Kingdom
  4. See more editors