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Latest articles

    1. Computational and Systems Biology
    2. Medicine

    Topological network analysis of patient similarity for precision management of acute blood pressure in spinal cord injury

    Abel Torres-Espín et al.
    The application of topological network analysis on multicenter high-frequency intra-operative physiology data discovers a precise range of blood pressure during surgery predicting poor recovery in spinal cord injury patients.
    1. Medicine

    Early prediction of clinical response to checkpoint inhibitor therapy in human solid tumors through mathematical modeling

    Joseph D Butner et al.
    A mechanistic mathematical model informed by standard‐of‐care imaging and pathology predicts tumor responses to immunotherapy a priori on a per-patient basis.
    1. Medicine
    2. Neuroscience

    Science Forum: Consensus-based guidance for conducting and reporting multi-analyst studies

    Balazs Aczel et al.
    Using multiple analysts to independently analyze the same dataset has the potential to explore and strengthen the robustness of results and conclusions in basic and applied research.
    1. Medicine
    2. Neuroscience

    scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution

    Bilge E Öztürk et al.
    A transcriptome-based pipeline (scAAVengr) quantifies and ranks competing adeno-associated viral vectors in primate retina, and mouse brain, heart, and liver, simultaneously and across all cell types, in the same animal, with single-cell resolution.
    1. Cell Biology
    2. Medicine

    Microtubules regulate pancreatic β-cell heterogeneity via spatiotemporal control of insulin secretion hot spots

    Kathryn P Trogden et al.
    Analysis of insulin secretion patterns in pancreatic islets shows that microtubules control β-cell heterogeneity by regulating initiation and timing of secretion hot spot activity in parallel with Ca2+ signaling.
    1. Cell Biology
    2. Medicine

    An experimental test of the effects of redacting grant applicant identifiers on peer review outcomes

    Richard K Nakamura et al.
    Redaction, intended to obscure personal and institutional identity, reduced the gap between Black vs. White applicants in simulated review of real NIH scientific grant applications, thus providing qualified support for double-blinded models of peer review.
    1. Cell Biology
    2. Medicine

    Funding: Blinding peer review

    Michael A Taffe
    Concealing the identity of the principal investigator only partially closes the success gap between white and African American or Black researchers in NIH grant applications.
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    1. Medicine
    2. Neuroscience

    Neural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality

    Angela Kim et al.
    Two non-overlapping neural circuits that involve the lamina terminalis and arcuate nucleus of hypothalamus independently drive feedforward anticipatory suppression and activation of vasopressin neurons by drinking and feeding, respectively.

Senior editors

  1. Wafik S El-Deiry
    Brown University, United States
  2. Mone Zaidi
    Icahn School of Medicine at Mount Sinai, United States
  3. Jos WM van der Meer
    Radboud University Medical Centre, Netherlands
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