Medicine

Latest articles

1. 1. Cell Biology
   2. Medicine

   Endometriosis is not the endometrium: Reviewing the over-representation of eutopic endometrium in endometriosis research

   Kate Gunther, Teagan Fisher ... Caroline Elizabeth Ford

   Nearly half of sequencing data labeled as endometriosis lacks true disease representation, highlighting the urgent need for more diverse and accurate tissue sampling to advance research in this underrepresented field.
2. 1. Medicine
   2. Neuroscience

   mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance

   Philip Stavrides, Chris N Goulbourne ... Dun-Sheng Yang

   ALP alterations in Q175 brains are late-onset, mild, existing at the later phases of the pathway, and stimulating autophagy at early disease progression enhances mHTT clearance to ameliorate HD pathology.
3. 1. Medicine

   Efficacy and safety of neoadjuvant stereotactic body radiation therapy plus dalpiciclib and exemestane for hormone receptor-positive, HER2-negative breast cancer: A prospective pilot study

   Yu Zhang, Shuo Cao ... Caigang Liu
4. 1. Cell Biology
   2. Medicine

   AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism

   Zongwang Zhang, Lixia Zheng ... Jing-Wei Xiong

   AARS2 safeguards cardiomyocytes against ischemic injury by modulating PKM2-driven energy metabolism, revealing the AARS2-PKM2 axis as a previously unrecognized cardioprotective pathway in myocardial infarction.
5. 1. Medicine

   Transparency of research practices in cardiovascular literature

   Gabriel O Heckerman, Eileen Tzng ... Adrienne Mueller

   Based on a standardized screening process, the simple majority of reviewed cardiovascular research publications lack sufficient information needed for the study to be replicated or reproduced.
6. 1. Medicine
   2. Epidemiology and Global Health

   Five-Year Survival Outcomes for Breast Cancer Patients Across Continental Africa: A Contemporary Review of Literature with Meta Analysis

   Augustina Badu-Peprah, Ernest Kissi Kontor ... Nityanand Jain
7. 1. Medicine

   Characterisation and comparison of semen microbiota and bacterial load in men with infertility, recurrent miscarriage, or proven fertility

   Shahriar Mowla, Linda Farahani ... Channa N Jayasena

   There are common seminal microbiome clusters in both healthy men and those with infertility and recurrent pregnancy loss, and some specific microbiota perturbations are associated with impaired semen quality.
8. 1. Medicine
   2. Microbiology and Infectious Disease

   HERV activation segregates ME/CFS from fibromyalgia while defining a novel nosologic entity

   Karen Giménez-Orenga, Eva Martín-Martínez ... Elisa Oltra

   Transcriptomic profiling of HERV elements at the loci level differentiates ME/CFS, fibromyalgia, and their overlap, revealing distinct immuno-epigenetic landscapes.
9. 1. Medicine
   2. Stem Cells and Regenerative Medicine

   Magnetically steered cell therapy for reduction of intraocular pressure as a treatment strategy for open-angle glaucoma

   M Reza Bahrani Fard, Jessica Chan ... C Ross Ethier
10. 1. Cell Biology
    2. Medicine

    Disruption of the novel nested gene Aff3ir mediates disturbed flow-induced atherosclerosis in mice

    Shuo He, Lei Huang ... Jinlong He

    Endothelial-specific supplementation with Aff3ir-ORF2 significantly ameliorated disturbed flow-induced endothelial activation and the development of atherosclerotic plaques, highlighting its promising therapeutic potential for the treatment of atherosclerosis.