Medicine

Latest articles

1. 1. Medicine

   Characterization and prediction of clinical pathways of vulnerability to psychosis through graph signal processing

   Corrado Sandini et al.

   A novel methodical approach aimed at improving translation of network analyses to psychopathology provides an intuitive representation of longitudinal clinical pathways between symptoms and can assist in predicting prognosis.
2. 1. Medicine
   2. Stem Cells and Regenerative Medicine

   Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19

   Courtney Tindle et al.

   An integrated stem cell-based disease modeling and computational approach demonstrates how proximal airway epithelium is critical for SARS-CoV-2 infectivity and distal alveolar cells are critical for simulating the host responses.
3. 1. Cancer Biology
   2. Medicine

   Cancer Immunotherapy: A promising platform for predicting toxicity

   Maria Ochoa de Olza

   Organ-on-chip approaches could help researchers to better predict the toxicity of cancer immunotherapy drugs.
4. 1. Medicine
   2. Microbiology and Infectious Disease

   Non-nucleoside reverse transcriptase inhibitor-based combination antiretroviral therapy is associated with lower cell-associated HIV RNA and DNA levels compared to protease inhibitor-based therapy

   Alexander O Pasternak et al.

   In two independent cohorts, NNRTI-based cART regimens are associated with significantly lower cell-associated HIV RNA levels than PI-based regimens, suggesting more potent suppression of residual virus replication by NNRTI-based regimens.
5. 1. Genetics and Genomics
   2. Medicine

   SMA-miRs: miR-181a-5p, -324-5p, -451a are overexpressed in spinal muscular atrophy skeletal muscle and serum samples

   Emanuela Abiusi et al.
6. 1. Medicine

   Aorta smooth muscle-on-a-chip reveals impaired mitochondrial dynamics as a therapeutic target for aortic aneurysm in bicuspid aortic valve disease

   Mieradilijiang Abudupataer et al.

   An aorta smooth muscle-on-a-chip model indicated that NOTCH1 insufficiency in HAoSMCs induced phenotypic switching from a contractile to a synthetic phenotype accompanied by an impairment of mitochondrial fusion, implying its potential role as a therapeutic target for BAV-TAA.
7. 1. Medicine

   Heparin-binding motif mutations of human diamine oxidase allow the development of a first-in-class histamine-degrading biopharmaceutical

   Elisabeth Gludovacz et al.

   Because heparin-binding motif mutations of human diamine oxidase (hDAO) block cellular uptake and strongly decrease clearance in vivo, modified recombinant hDAO might be a good candidate for the treatment of symptoms induced by excessive endogenous histamine release.
8. 1. Medicine
   2. Neuroscience

   Skeleton interoception regulates bone and fat metabolism through hypothalamic neuroendocrine NPY

   Xiao Lv et al.

   PGE2/EP4 skeleton interoception regulates bone and fat metabolism via hypothalamic NPY.
9. 1. Cancer Biology
   2. Medicine

   Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies

   S Jordan Kerns et al.

   Novel human models of the lung and intestine are described and validated as preclinical in vitro tools for predictive profiling of T-cell-bispecific antibodies with expected on-target off-tumor risk.
10. 1. Epidemiology and Global Health
    2. Medicine

    Role of direct and indirect social and spatial ties in the diffusion of HIV and HCV among people who inject drugs: a cross-sectional community-based network analysis in New Delhi, India

    Steven J Clipman et al.

    Beyond well-recognized individual-level risk factors, HIV and hepatitis C transmission among people who inject drugs are further impacted by social and spatial network composition, and spaces in particular may represent efficient means for disseminating interventions that diffuse through the network.