Medicine

Latest articles

1. 1. Medicine

   Gut Microbial Trimethylamine is Elevated in Alcohol-Associated Hepatitis and Contributes to Ethanol-Induced Liver Injury in Mice

   Robert N Helsley et al.
2. 1. Epidemiology and Global Health
   2. Medicine

   Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort

   ISARIC Clinical Characterisation Group et al.

   Patient outcomes, and the time spent by patients during hospital admission, showed considerable variation over the first year of the COVID-19 pandemic.
3. 1. Medicine
   2. Stem Cells and Regenerative Medicine

   Therapeutic downregulation of neuronal PAS domain 2 (Npas2) promotes surgical skin wound healing

   Yoichiro Shibuya et al.

   A small molecule compound Dwn1, identified through high-throughput screening using Npas2 as the molecular target, enhances wound healing in a murine incisional wound model.
4. 1. Epidemiology and Global Health
   2. Medicine

   Development, validation, and application of a machine learning model to estimate salt consumption in 54 countries

   Wilmer Cristobal Guzman-Vilca et al.

   A machine learning model could accurately estimate daily salt consumption in the general population and can be applied to countries lacking urine sample to compute the mean salt consumption at the population level.
5. 1. Computational and Systems Biology
   2. Medicine

   Personalized computational heart models with T1-mapped fibrotic remodeling predict sudden death risk in patients with hypertrophic cardiomyopathy

   Ryan P O'Hara et al.

   Personalized virtual-heart technology for arrhythmia risk assessment could transform the management of hypertrophic cardiomyopathy patients, eliminating many unnecessary primary-prevention defibrillator deployments while ensuring patients at high risk for arrhythmia are adequately protected.
6. 1. Medicine

   Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms

   Rebecca C Schugar et al.
7. 1. Biochemistry and Chemical Biology
   2. Medicine

   RNA binding to human METTL3-METTL14 restricts N⁶-deoxyadenosine methylation of DNA in vitro

   Shan Qi et al.
8. 1. Immunology and Inflammation
   2. Medicine

   Effects of IFIH1 rs1990760 variants on systemic inflammation and outcome in critically ill COVID-19 patients in an observational translational study

   Laura Amado-Rodríguez et al.

   Patients with different rs1990760 variants have a differential inflammatory response to severe SARS-CoV-2 infections, so that those with a TT genotype have an attenuated systemic inflammation and may not benefit from steroid therapy.
9. 1. Medicine

   ACE2 pathway regulates thermogenesis and energy metabolism

   Xi Cao et al.

   A series of functional assays in mouse models and primary brown adipocytes confirm that the ACE2 pathway regulates glucose and lipid homeostasis, and maintains thermogenesis and systemic energy metabolism by both the Akt and PKA signaling.
10. 1. Computational and Systems Biology
    2. Medicine

    A human-based multi-gene signature enables quantitative drug repurposing for metabolic disease

    James A Timmons et al.

    Optimising the use of transcriptomics enables screening of thousands of compounds and illustrates an approach that yields quantitative pharmacology at the single-gene and pathway level.