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Latest articles

    1. Medicine

    Cell-autonomous and non-cell-autonomous effects of arginase-II on cardiac aging

    Duilio M Potenza, Xin Cheng ... Xiu-Fen Ming
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Medicine

    Aging: Multiple roles for a mitochondrial enzyme

    Xicong Tang, Hongyu Qiu
    The enzyme arginase-II has an important role in cardiac aging, and blocking it could help hearts stay young longer.
    Version of Record
    Insight
    1. Medicine

    Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans

    Yifan Xiang, Vineeta Tanwar ... Pankaj Kapahi
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Medicine

    The denitrosylase SCoR2 controls cardioprotective metabolic reprogramming

    Zachary W Grimmett, Rongli Zhang ... Jonathan S Stamler
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Compelling
    1. Medicine
    2. Computational and Systems Biology

    Calibration and validation strategy for electromechanical cardiac digital twins

    Zhinuo Jenny Wang, Maxx Holmes ... Blanca Rodriguez
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Medicine
    2. Immunology and Inflammation

    C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

    Toru Tanaka, Naoto Sasaki ... Yoshiyuki Rikitake
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Incomplete
    1. Medicine
    2. Neuroscience

    Diet modulates the therapeutic effects of dimethyl fumarate mediated by the immunometabolic neutrophil receptor HCAR2

    Joanna Kosinska, Julian C Assmann ... Markus Schwaninger
    The therapeutic effect of dimethyl fumarate in experimental autoimmune encephalomyelitis depends on the diet of mice and is mediated by the G protein-coupled receptor HCAR2 in neutrophils.
    1. Cancer Biology
    2. Medicine

    Molecular feature-based classification of retroperitoneal liposarcoma: a prospective cohort study

    Mengmeng Xiao, Xiangji Li ... Li Min
    Identification of two molecularly distinct retroperitoneal liposarcoma subtypes, stratifiable via LEP and PTTG1 biomarkers, enables prognosis prediction and informs precision surgical strategies to improve clinical outcomes.
    1. Medicine

    Gamma Knife Stereotactic radiotherapy combined with tislelizumab as later-line therapy in hpMMR/MSS/MSI-L metastatic colorectal cancer: A Phase II Trial Analysis

    Yiran Zhang, Hanyang Guan ... Jinghua Pan
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Medicine
    2. Neuroscience

    mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance

    Philip Stavrides, Chris N Goulbourne ... Dun-Sheng Yang
    ALP alterations in Q175 brains are late-onset, mild, existing at the later phases of the pathway, and stimulating autophagy at early disease progression enhances mHTT clearance to ameliorate HD pathology.
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    1. Epidemiology and Global Health
    2. Medicine
    3. Microbiology and Infectious Disease

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    Edited by Diane M Harper et al.
    1. Medicine

    Meet our new Senior Editors in Medicine

    1. Medicine
    2. Epidemiology and Global Health
    virus

    We’ve extended the deadline for our call for papers on the impact of COVID-19 on cancer

Senior editors

  1. Matthias Barton
    University of Zurich, Switzerland
  2. Balram Bhargava
    Indian Council of Medical Research, India
  3. Joshua T Schiffer
    Fred Hutchinson Cancer Research Center, United States
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