Medicine

Latest articles

1. 1. Medicine
   2. Computational and Systems Biology

   Identification of type 2 diabetes- and obesity-associated human β-cells using deep transfer learning

   Gitanjali Roy, Rameesha Syed ... Michael A Kalwat
2. 1. Medicine

   The denitrosylase SCoR2 controls cardioprotective metabolic reprogramming

   Zachary W Grimmett, Rongli Zhang ... Jonathan S Stamler
3. 1. Genetics and Genomics
   2. Medicine

   Heterozygous variants in PLCG1 affect hearing, vision, cardiac, and immune function

   Mengqi Ma, Yiming Zheng ... Undiagnosed Diseases Network

   Clinical, genetic, and model organism data collectively define PLCG1 as a disease-associated gene with diverse missense variants contributing to phenotypic heterogeneity.
4. 1. Immunology and Inflammation
   2. Medicine

   A pair of congenic mice for imaging of transplants by positron emission tomography using anti-transferrin receptor nanobodies

   Thomas Balligand, Claire Carpenet ... Maarten Dewilde

   Two radio-labeled nanobodies and a single knock-in mouse model suffice to track the biodistribution of various unmodified cell-types in live mice by PET/CT.
5. 1. Medicine

   Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans

   Yifan Xiang, Vineeta Tanwar ... Pankaj Kapahi

   Mendelian randomization offers novel insights into the genetic factors that influence the aging process through early-life reproductive events, providing robust evidence for the antagonistic pleiotropy theory in humans.
6. 1. Medicine
   2. Neuroscience

   Acute aerobic exercise intensity does not modulate pain potentially due to differences in fitness levels and sex effects: results from a pharmacological fMRI study

   Janne Ina Nold, Tahmine Fadai, Christian Büchel

   Exercise intensity alone does not differentially reduce pain, but individual factors like fitness level and sex, along with opioid mechanisms, may influence exercise-induced pain relief.
7. 1. Medicine

   Efficacy and safety of neoadjuvant stereotactic body radiation therapy plus dalpiciclib and exemestane for hormone receptor-positive, HER2-negative breast cancer: A prospective pilot study

   Yu Zhang, Shuo Cao ... Caigang Liu

   Neoadjuvant SBRT with dalpiciclib and exemestane resulted in a 16.7% RCB 0-I rate and a 91.7% ORR, with acceptable toxicities in HR-positive, HER2-negative breast cancer patients.
8. 1. Medicine
   2. Cancer Biology

   Monitoring Circulating Cell-free HPV DNA in Metastatic and Recurrent Cervical Cancer: Clinical Importance and Implications for Treatment - A Pilot Study

   Zhuomin Yin, Tao Feng ... Hanmei Lou
9. 1. Medicine

   Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc

   Changli Zhang, Martha Elena Diaz-Hernandez ... Hicham Drissi

   PDGF mitigated cellular senescence in human intervertebral disc by modulating cell cycle, inflammation, and mitochondria function, offering a potential strategy for combating age-induced disc degeneration.
10. 1. Genetics and Genomics
    2. Medicine

    EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis

    Lianlei Wang, Xinyu Yang ... Nan Wu

    EPHA4 pathway dysfunction causes axon pathfinding defects, resulting in impaired coordinated left-right locomotion by disrupting neural patterning and the function of central pattern generators, thereby potentially leading to idiopathic scoliosis.