Medicine

Latest articles

1. 1. Cell Biology
   2. Medicine

   Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide

   Thao DV Le, Dianxin Liu ... Julio E Ayala

   The ability of the therapeutic glucagon-like peptide-1 receptor agonist liraglutide to promote weight loss is partly dependent on signaling via PKA-dependent phosphorylation of the mTORC1 regulator protein Raptor.
2. 1. Epidemiology and Global Health
   2. Medicine

   Association between bisphosphonate use and COVID-19 related outcomes

   Jeffrey Thompson, Yidi Wang ... Ulrich H von Andrian

   A claims-based retrospective cohort study shows that patients who used bisphosphonates between 01/01/2019 and 02/29/2020 had dramatically reduced odds of SARS-CoV-2 testing, COVID-19 diagnosis, and COVID-19-related hospitalizations during the initial surge of the COVID-19 pandemic in the US.
3. 1. Medicine

   Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity

   Christin Krause, Jan H. Britsemmer ... Henriette Kirchner
4. 1. Medicine

   A single-cell atlas depicting the cellular and molecular features in human anterior cruciate ligamental degeneration: A single cell combined spatial transcriptomics study

   Runze Yang, Tianhao Xu ... Weili Fu

   Single-cell combined spatial transcriptomics provides the molecular foundation for investigating how ligamental cell identities, biochemical functions, and interactions contributed to the ligamental degeneration process.
5. 1. Cancer Biology
   2. Medicine

   Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology

   Won Yeong Park, Jieun Yun ... Ki Hean Kim
6. 1. Epidemiology and Global Health
   2. Medicine

   Pharmacometric assessment of primaquine induced haemolysis in glucose-6-phosphate dehydrogenase deficiency

   Sasithon Pukrittayakamee, Podjanee Jittamala ... Nicholas J White
7. 1. Medicine

   Resistance exercise protects mice from protein-induced fat accretion

   Michaela E Trautman, Leah N Braucher ... Dudley W Lamming

   A high-protein diet promotes unfavorable metabolic effects in mice, but resistance exercise training protects from some of these effects while promoting muscle hypertrophy and increased strength.
8. 1. Medicine

   Endothelial dysfunction in acute myocardial infarction: cell-autonomous metabolic reprogramming and oxidative stress

   Erika Zodda, Olga Tura-Ceide ... Marta Cascante
9. 1. Immunology and Inflammation
   2. Medicine

   Concerted changes in the pediatric single-cell intestinal ecosystem before and after anti-TNF blockade

   Hengqi Betty Zheng, Benjamin A. Doran ... Leslie S. Kean
10. 1. Medicine

    Eleven strategies for making reproducible research and open science training the norm at research institutions

    Friederike E Kohrs, Susann Auer ... Tracey L Weissgerber

    Researchers and administrators can integrate reproducible research and open science practices into daily practice at their research institutions by adapting research assessment criteria and program requirements, offering training, and building communities.