Medicine

Latest articles

1. 1. Medicine

   Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans

   Yifan Xiang, Vineeta Tanwar ... Pankaj Kapahi

   Mendelian randomization offers novel insights into the genetic factors that influence the aging process through early-life reproductive events, providing robust evidence for the antagonistic pleiotropy theory in humans.
2. 1. Medicine
   2. Neuroscience

   Acute aerobic exercise intensity does not modulate pain potentially due to differences in fitness levels and sex effects: results from a pharmacological fMRI study

   Janne Ina Nold, Tahmine Fadai, Christian Büchel

   Exercise intensity alone does not differentially reduce pain, but individual factors like fitness level and sex, along with opioid mechanisms, may influence exercise-induced pain relief.
3. 1. Medicine

   Efficacy and safety of neoadjuvant stereotactic body radiation therapy plus dalpiciclib and exemestane for hormone receptor-positive, HER2-negative breast cancer: A prospective pilot study

   Yu Zhang, Shuo Cao ... Caigang Liu

   Neoadjuvant SBRT with dalpiciclib and exemestane resulted in a 16.7% RCB 0-I rate and a 91.7% ORR, with acceptable toxicities in HR-positive, HER2-negative breast cancer patients.
4. 1. Medicine
   2. Cancer Biology

   Monitoring Circulating Cell-free HPV DNA in Metastatic and Recurrent Cervical Cancer: Clinical Importance and Implications for Treatment - A Pilot Study

   Zhuomin Yin, Tao Feng ... Hanmei Lou
5. 1. Medicine

   Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc

   Changli Zhang, Martha Elena Diaz-Hernandez ... Hicham Drissi

   PDGF mitigated cellular senescence in human intervertebral disc by modulating cell cycle, inflammation, and mitochondria function, offering a potential strategy for combating age-induced disc degeneration.
6. 1. Genetics and Genomics
   2. Medicine

   EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis

   Lianlei Wang, Xinyu Yang ... Nan Wu

   EPHA4 pathway dysfunction causes axon pathfinding defects, resulting in impaired coordinated left-right locomotion by disrupting neural patterning and the function of central pattern generators, thereby potentially leading to idiopathic scoliosis.
7. 1. Medicine
   2. Immunology and Inflammation

   A pair of congenic mice for imaging of transplants by positron emission tomography using anti-transferrin receptor nanobodies

   Thomas Balligand, Claire Carpenet ... Maarten Dewilde
8. 1. Medicine

   Gender differences in submission behavior exacerbate publication disparities in elite journals

   Chaoqun Ni, Isabel Basson ... Vincent Larivière
9. 1. Medicine

   Noninvasive ultrasound targeted modulation of calcium influx in splenic immunocytes potentiates antineoplastic immunity attenuating hepatocellular carcinoma proliferation

   Wei Dong, Guihu Wang ... Zongfang Li
10. 1. Medicine
    2. Stem Cells and Regenerative Medicine

    Magnetically steered cell therapy for reduction of intraocular pressure as a treatment strategy for open-angle glaucoma

    M Reza Bahranifard, Jessica Chan ... C Ross Ethier

    Magnetically steered mesenchymal stem cells significantly lowered intraocular pressure for 9 months in mice, motivating the translation of this technology for the treatment of glaucoma.