Medicine

Latest articles

1. 1. Medicine

   Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts

   Maxime RF Gosselin, Virginie Mournetas ... Dariusz C Gorecki

   Loss of full-length dystrophin expression causes significant molecular and functional defects in human and mouse myoblast, thus closing the vicious cycle of DMD pathology.
2. 1. Immunology and Inflammation
   2. Medicine

   Neutrophil-mediated fibroblast-tumor cell il-6/stat-3 signaling underlies the association between neutrophil-to-lymphocyte ratio dynamics and chemotherapy response in localized pancreatic cancer: A hybrid clinical-preclinical study

   Iago de Castro Silva, Anna Bianchi ... Jashodeep Datta

   A neutrophil-CAF-tumor cell IL-1β/IL-6/STAT-3 signaling axis in the pancreatic tumor microenvironment underlies the association between neutrophil-to-lymphocyte ratio dynamics and pathologic response in patients with pancreatic ductal adenocarcinoma undergoing neoadjuvant therapy.
3. 1. Immunology and Inflammation
   2. Medicine

   Bone marrow adipocytes drive the development of tissue invasive Ly6C^high monocytes during obesity

   Parastoo Boroumand, David C Prescott ... Amira Klip

   Diet-induced obesity in mice led to a duration of diet-dependent bone marrow adipocyte whitening, which drove monocyte expansion and skewing towards a tissue-invasive phenotype, likely contributing to ensuing tissue infiltration that accompanies obesity and diabetes.
4. 1. Medicine
   2. Neuroscience

   Repressor element 1-silencing transcription factor deficiency yields profound hearing loss through K_v7.4 channel upsurge in auditory neurons and hair cells

   Haiwei Zhang, Hongchen Li ... Ping Lv
5. 1. Medicine

   FSH-blocking therapeutic for osteoporosis

   Sakshi Gera, Tan-Chun Kuo ... Mone Zaidi
6. 1. Epidemiology and Global Health
   2. Medicine

   The Ellipse of Insignificance, a refined fragility indexfor ascertaining robustness of results indichotomous outcome trials

   David Robert Grimes
7. 1. Cancer Biology
   2. Medicine

   Photonic hyperthermia of malignant peripheral nerve sheath tumors at the third near-infrared biowindow

   Yihui Gu, Zhichao Wang ... Qingfeng Li
8. 1. Medicine
   2. Neuroscience

   Sleep EEG in young people with 22q11.2 deletion syndrome: A cross-sectional study of slow-waves, spindles and correlations with memory and neurodevelopmental symptoms

   Nicholas A Donnelly, Ullrich Bartsch ... Matt W Jones

   Measures of sleep features such as spindles and slow waves differentiate between young people with 22q11.2 microdeletion syndrome and healthy controls, and may mediate the relationship between this genotype and psychiatric symptoms.
9. 1. Medicine
   2. Neuroscience

   Stage-dependent differential influence of metabolic and structural networks on memory across Alzheimer’s disease continuum

   Kok Pin Ng, Xing Qian ... Alzheimer's Disease Neuroimaging Initiative

   The early influence of the breakdown of both hippocampal structural network and angular gyrus-seeded default mode metabolism network on memory performance underscore the importance of early intervention in preclinical Alzheimer’s disease.
10. 1. Medicine

    Brain atlas for glycoprotein hormone receptors at single-transcript level

    Vitaly Ryu, Anisa Gumerova ... Mone Zaidi

    The most comprehensive neuroanatomical atlas on the expression of three glycoprotein hormone receptors, namely, TSHRs, LHCGRs, and FSHRs, was mapped using RNAscope, a technology that allows the detection of mRNA at single-transcript level.