Medicine

Medicine

eLife publishes research and clinical studies that deal with etiology, pathophysiology, diagnosis, genetics, prevention, and treatment of human disease. Learn more about what we publish and sign up for the latest research.
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Latest articles

    1. Genetics and Genomics
    2. Medicine

    Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome

    Jeanne L Theis et al.
    Hypoplastic left heart syndrome is reflected by reduced proliferative capacity of patient iPSC-derived cardiomyocytes and requires the activity of LRP2/APOB proteins, likely in conjunction with SHH and WNT signaling pathways.
    1. Medicine
    2. Neuroscience

    Parkinson’s Disease: Debunking an old theory

    Teresa Spix, Aryn Gittis
    Recording the neural activity of cells in the brain of patients with Parkinson's disease challenges long-standing assumptions about how this disease manifests at the cellular level.
    Insight
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    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Lysosomal protein surface expression discriminates fat- from bone-forming human mesenchymal precursor cells

    Jiajia Xu et al.
    CD107a expression divides osteogenic from adipogenic perivascular precursor cells within human white adipose tissue.
    1. Genetics and Genomics
    2. Medicine

    PTPRG is an ischemia risk locus essential for HCO3-dependent regulation of endothelial function and tissue perfusion

    Kristoffer B Hansen et al.
    HCO3-sensitive regulation of endothelium-dependent vasorelaxation by receptor-type tyrosine-protein phosphatase RPTPγ provides a novel mechanism for acid-base-mediated coordination of cerebrovascular perfusion during increased local metabolism and for protection against ischemia.
    1. Medicine

    Lack of airway submucosal glands impairs respiratory host defenses

    Lynda S Ostedgaard et al.
    Submucosal glands are critical for two key respiratory host defenses, bactericidal activity and mucociliary transport, in an animal model that has lungs like humans.

Highlights

    1. Medicine
    2. Neuroscience

    Excitation, inhibition and autism

    Charlotte M Pretzsch, Dorothea L Floris
    1. Medicine

    COVID-19 papers have fewer women first authors

    Jens Peter Andersen et al.
    1. Medicine

    Drug Discovery: From worms to fish to mice

    Guy M Benian, Hyojung J Choo

Senior editors

  1. Matthias Barton
    University of Zurich, Switzerland
  2. Christian Büchel
    University Medical Center Hamburg-Eppendorf, Germany
  3. Gary Westbrook
    Vollum Institute, United States
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