Medicine

Latest articles

1. 1. Medicine
   2. Microbiology and Infectious Disease

   HERV activation segregates ME/CFS from fibromyalgia while defining a novel nosologic entity

   Karen Giménez-Orenga, Eva Martín-Martínez ... Elisa Oltra
2. 1. Medicine

   Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa

   Hyun Beom Song, Laura Campello ... Anand Swaroop

   Reserpine, previously identified through high-throughput screening in CEP290 retinal degeneration models, enhances photoreceptor survival in P23H rhodopsin retinal degeneration models, particularly in female rats, indicating its gene-agnostic and sex-specific effectiveness.
3. 1. Cell Biology
   2. Medicine

   Disruption of the Novel Nested Gene Aff3ir Mediates Disturbed Flow-Induced Atherosclerosis in Mice

   Shuo He, Lei Huang ... Jinlong He
4. 1. Cell Biology
   2. Medicine

   Pulmonary Hypertension: When cell teamwork turns toxic

   Wadih EI Khoury, Stephen Y Chan

   In pulmonary hypertension, a combination of metabolic and mechanical dysfunction leads to irreversible vascular damage.
5. 1. Cell Biology
   2. Medicine

   Adventitial fibroblasts direct smooth muscle cell-state transition in pulmonary vascular disease

   Slaven Crnkovic, Helene Thekkekara Puthenparampil ... Grazyna Kwapiszewska

   Transition from healthy to diseased state is a cell-type-specific process, influenced by neighboring cells and resulting in functionally meaningful differences between pulmonary artery adventitial fibroblasts and smooth muscle cells.
6. 1. Medicine

   Transplantation of exogenous mitochondria mitigates myocardial dysfunction after cardiac arrest

   Zhen Wang, Jie Zhu ... Xiang Zhou

   Exogenous mitochondrial transplantation improves cardiac function after cardiopulmonary resuscitation (CPR) may be related to improving mitochondrial function, reducing the oxidative stress response, and decreasing apoptosis in myocardial cells.
7. 1. Medicine

   Dynamics of compartment-specific proteomic landscapes of hepatotoxic and cholestatic models of liver fibrosis

   Marketa Jirouskova, Karel Harant ... Martin Gregor

   A comprehensive proteomic map of liver fibrosis progression and healing in two mouse models identifies etiology-specific extracellular matrix components, laying the foundation for targeted antifibrotic therapies.
8. 1. Medicine
   2. Neuroscience

   Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents

   Ayni Sharif, Matthew S Jeffers ... Manoj M Lalu

   CCR5 antagonists show promise for stroke cerebroprotection and recovery, although further preclinical evidence in clinically relevant domains could strengthen support for clinical translation.
9. 1. Medicine

   Pyrotinib after trastuzumab-based adjuvant therapy in patients with HER2-positive breast cancer (PERSIST): A multicenter phase II trial

   Feilin Cao, Zhaosheng Ma ... Shifen Huang

   Kaplan–Meier curves showed that extended adjuvant pyrotinib administered after trastuzumab-based adjuvant therapy provides a promising survival benefit in patients with high-risk HER2-positive breast cancer.
10. 1. Immunology and Inflammation
    2. Medicine

    Deciphering the preeclampsia-specific immune microenvironment and the role of pro-inflammatory macrophages at the maternal–fetal interface

    Haiyi Fei, Xiaowen Lu ... Lingling Jiang

    Multi-omics analysis shows that preeclampsia-specific immune cell network was regulated by Folr2⁺Ccl7⁺Ccl8⁺C1qa⁺C1qb⁺C1qc⁺ pro-inflammatory macrophages, which can induce the CD8⁺ and Th17 memory T cells generation while inhibiting the gMDSCs production.