Editors for Structural Biology and Molecular Biophysics

We aim to review studies that advance our understanding of molecular mechanisms in biology, using experimental and computational approaches to provide quantitative insights. We also welcome studies describing structure determination by methods including cryoEM, crystallography and NMR, the investigation of macromolecular dynamics, the evolution of function and specificity in molecular systems, and the application of advanced biophysical methods to capture molecules in action. Read the latest research in this subject area.

Senior editors

  1. Amy H Andreotti

    Iowa State University, United States

    Amy Andreotti is the Roy J Carver Chair in Biochemistry and a University Professor at Iowa State University. She joined the faculty of the Roy J Carver Department of Biochemistry, Biophysics and Molecular Biology in 1997 after earning her PhD in Chemistry at Princeton University and completing a postdoctoral training period in the Chemistry Department at Harvard University where she was a Science Scholar at the Bunting Institute of Radcliffe College. Her work explores the mechanisms of kinase regulation during cell signaling with an emphasis on the immune specific TEC family of non-receptor tyrosine kinases. A particular focus of the lab is Bruton’s tyrosine kinase (BTK) and its interactions with small molecule therapeutics. Her lab uses a variety of biochemical, enzymatic and structural biology methods including solution NMR spectroscopy.

    Expertise
    Structural Biology and Molecular Biophysics
    Biochemistry and Chemical Biology
    Research focus
    NMR spectroscopy
    kinase regulation
    cell signalling
    Tec family kinases
    Experimental organism
    human
    Competing interests statement
    Amy Andreotti's research is currently funded by the National Institutes of Health. She also serves on the National Advisory Committee for the Biomedical Scholars program of the Pew Charitable Trusts.
  2. Felix Campelo

    The Institute of Photonic Sciences, Spain

    Felix Campelo is a researcher specializing in membrane biophysics, cell biology, and fluorescence microscopy tools to understand intracellular organization. He did his PhD research in theoretical biophysics at the University of Barcelona and Tel Aviv University, developing computational and theoretical methods to study membrane shape and dynamics. In his postdoc at the Malhotra lab (CRG-Center for Genomic Regulation), he shifted to experimental cell biology and biochemistry to explore mechanisms of intracellular trafficking and the cooperation between lipids and proteins in organizing Golgi membranes.

    Currently leading the Intracellular Dynamics and Nanoscopy lab at ICFO-The Institute of Photonic Sciences in Barcelona, Felix and his interdisciplinary lab focus on organelle morphology and dynamics, with a particular interest in intracellular membrane trafficking in the early secretory pathway. They employ advanced microscopy techniques, molecular and cell biology tools, and theoretical biophysics to address fundamental topics in cell biology.

    Expertise
    Physics of Living Systems
    Cell Biology
    Structural Biology and Molecular Biophysics
    Research focus
    membrane mechanics
    membrane curvature
    intracellular trafficking
    membrane organization
    membrane contact sites
    Golgi complex
    endoplasmic reticulum exit sites
    super-resolution microscopy
    single-molecule microscopy
    Experimental organism
    human
    S. cerevisiae
    Competing interests statement
    Dr Campelo receives funding from Government of Spain, Fundació Privada Cellex, Fundació Privada Mir-Puig, and Generalitat de Catalunya.
  3. Qiang Cui

    Boston University, United States

    Qiang Cui is a professor of Chemistry at Boston University and also affiliated with the Departments of Physics and Biomedical Engineering. He received a B.S. in Chemical Physics from the University of Science and Technology of China in 1993, and a Ph.D. in Theoretical Chemistry in 1997 from Emory University under the tutelage of Professor Keiji Morokuma. He conducted postodctoral research with Professor Martin Karplus at Harvard University and, in 2001, moved to the University of Wisconsin, Madison, as a faculty member in the Chemistry department. After spending almost 17 wonderful years in Madison, he moved back to Boston in 2018. His current research interests include quantum chemistry and statistical mechanics and their applications to various chemical, biological, and materials problems.

    Expertise: Computational biophysics, especially molecular dynamics, hybrid quantum mechanical/molecular mechanics simulations, free energy simulations applied to enzymes, biomolecular machines and lipid membranes.

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    molecular dynamics
    hybrid quantum
    classical simulations
    enzyme catalysis
    allostery
    protein dynamics
    membrane remodeling
    Competing interests statement
    Qiang Cui currently serves as an associate editor for the Journal of Chemical Theory and Computation (American Chemical Society).
  4. Volker Dötsch

    Goethe University, Germany

    Volker Dötsch is Professor of Biophysical Chemistry at Goethe University and a member of the Magnetic Resonance Center Frankfurt. He studied chemistry at the University of Göttingen and obtained a PhD from the ETH in Zürich. As a postdoctoral fellow he used NMR to determine the structure of protein-DNA complexes at the Harvard Medical School. In 1998 he moved as assistant professor to the University of California San Francisco (UCSF). In 2003 he was appointed professor at the Institute of Biophysical Chemistry of Goethe University in Frankfurt. His research interests focus on the structural and functional characterization of members of the p53 protein family, in particular p63 and its involvement in genetic quality control in germ cells. In addition, his laboratory uses a combination of NMR spectroscopy and cell-free protein expression to investigate the structure and function of membrane proteins and studies molecular interactions regulating autophagy. His lab uses a wide variety of biophysical methods including NMR spectroscopy and combines these studies with investigations in cell culture experiments and mouse models. Volker Dötsch is an elected EMBO member.

    Expertise
    Structural Biology and Molecular Biophysics
    Biochemistry and Chemical Biology
    Research focus
    p53 protein family
    cell-free expression and membrane protein structure and function
    autophagy
    Competing interests statement
    Volker Dötsch has received funding from the Deutsche Forschungsgemeinschaft, the National Institutes of Health and the Deutsche Krebshilfe. He is on the Scientific Advisory Board of the Frankfurt Institute of Advanced Studies and a member of the editorial boards of Journal of Biological Chemistry and Cell Death & Disease.
  5. Merritt Maduke

    Stanford University School of Medicine, United States

    Merritt Maduke is an Associate Professor of Molecular & Cellular Physiology and co-director of the Neurosciences Interdisciplinary Graduate Program at Stanford University School of Medicine. She received her PhD in Chemistry from the University of California, San Diego and did postdoctoral training at Brandeis University with Professor Chris Miller. Her research at Stanford is centered on the biophysics of ion channels and transporters, with the overarching goal of understanding molecular mechanisms within the context of physiological functions. She also applies her mechanistic approach in the field of ultrasound neuromodulation. She was awarded the Society of General Physiologist’s Cranefield Award for her research on ion channels (2008) and served as the Society’s President from 2018-2019.

    Expertise
    Structural Biology and Molecular Biophysics
    Neuroscience
    Biochemistry and Chemical Biology
    Research focus
    ion channel and transporter molecular mechanisms
    ion channel and transporter physiology
    ion channel and transporter pharmacology
    ultrasound neuromodulation
    Experimental organism
    E. coli
    mouse
    rat
    Competing interests statement
    Merritt Maduke is employed by Stanford University and receives research funding from the National Institutes of Health and Stanford Innovative Medicine Accelerator. She has served on the BPNS and BBM study sections at the NIH and as ad hoc member of additional panels. She serves on the editorial boards of the Biophysical Journal and The Journal of General Physiology and is a founding curator for Biophysics Colab.
  6. Kenton J Swartz

    National Institute of Neurological Disorders and Stroke, NIH, United States

    Kenton Swartz has been a Senior Investigator in the National Institute of Neurological Disorders and Stroke within the National Institutes of Health in Bethesda, Maryland since 2003. He obtained a BS in Chemistry and Biology from Eastern Mennonite College in 1986 and a PhD in Neurobiology from Harvard Medical School in 1993, where he worked with Bruce Bean studying the regulation of voltage-gated calcium channels by G-proteins and protein kinases. He obtained postdoctoral training with Roderick MacKinnon at Harvard Medical School, where he began isolating and studying toxins that interact with voltage-activated potassium channels. His laboratory uses biochemical, molecular biological, biophysical and structural techniques to understand how ion channel proteins sense critical biological stimuli, including membrane voltage, temperature, and both chemical and mechanical signals. He received an NIH Directors Award for Scientific Achievement in 2008, an NIH Office of the Director Honor Award on behalf of the Diversity Task Force in 2011 and the Kenneth S. Cole Award from the Biophysical Society in 2017. He has also served as the president of the Society of General Physiologists.

    Expertise
    Structural Biology and Molecular Biophysics
    Neuroscience
    Biochemistry and Chemical Biology
    Research focus
    ion channel structure
    ion channel mechanisms
    ion channel physiology
    ion channel pharmacology
    Experimental organism
    mouse
    Competing interests statement
    Kenton Swartz is employed by the Intramural Research Program of the National Institute of Neurological Disorders and Stroke, National Institutes of Health. In addition to serving as a Senior Editor at eLife, he has served as a Reviewing Editor for eLife and as an Associate Editor at the Journal of General Physiology. He also teaches yoga at LifeTime Athletic.

Reviewing editors

  1. Sameh Ali

    Children's Cancer Hospital Egypt, Egypt

    Expertise
    Biochemistry and Chemical Biology
    Cancer Biology
    Cell Biology
    Immunology and Inflammation
    Neuroscience
    Structural Biology and Molecular Biophysics
    Research focus
    metabolism
    mitochondria
    redox biology
    reactive oxygen species
    membrane biophysics
    inflammation
    aging
    oncology
  2. Toby W Allen

    RMIT University, Australia

    Expertise
    Structural Biology and Molecular Biophysics
    Physics of Living Systems
    Neuroscience
    Research focus
    computational biophysics
    molecular dynamics
    free-energy calculations
    ion channels
    ion permeation
    membranes
  3. Patricia Bassereau

    Institut Curie, France

    Expertise
    Cell Biology
    Physics of Living Systems
    Structural Biology and Molecular Biophysics
    Research focus
    physics of cells
    membrane biophysics
    mechanobiology
    intracellular traffic
    endocytosis
    adhesion
    cellular protrusions
    biomimetic membranes
  4. Kurt Beam

    University of Colorado Anschutz Medical Campus, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Neuroscience
    Physics of Living Systems
    Research focus
    excitation-contraction coupling in skeletal muscle
    voltage-gated calcium channels
    calcium release channels
  5. Amie K Boal

    Pennsylvania State University, United States

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    bioinorganic chemistry
    enzymes
    microbial chemistry
    x-ray crystallography
  6. Axel T Brunger

    Stanford University, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Neuroscience
    Research focus
    neurotransmission
    membrane fusion
    X-ray crystallography
    electron microscopy
    macromolecular computer simulation
    Experimental organism
    mouse
  7. Henry M Colecraft

    Columbia University, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Cell Biology
    Research focus
    ion channels
    ion channel regulation
    voltage-gated calcium channels
    ubiquitin
    ion channelopathy
    Experimental organism
    human
    mouse
    rat
  8. Rosana Collepardo

    University of Cambridge, United Kingdom

    Expertise
    Structural Biology and Molecular Biophysics
    Research focus
    epigenetic phenomena
    DNA structure
    gene expression
    molecular modeling
  9. Mauricio Comas-Garcia

    Universidad Autónoma de San Luis Potosí, Mexico

    Expertise
    Microbiology and Infectious Disease
    Structural Biology and Molecular Biophysics
    Research focus
    physical virology
    RNA packaging
    viral assembly
    virus-like-particle
    vaccines
    RNA viruses
    structural virology
    biophysics
  10. Laszlo Csanady

    Semmelweis University, Hungary

    Expertise
    Structural Biology and Molecular Biophysics
    Research focus
    ion channel structure-function
    CFTR
    TRPM2
  11. Laura R Delgui

    National Scientific and Technical Research Council, Argentina

    Expertise
    Cell Biology
    Microbiology and Infectious Disease
    Structural Biology and Molecular Biophysics
    Research focus
    virus-host cell interactions
    membranes
    molecular biology
    cellular biology
    structural biology
    biophysics
    molecular dynamics
  12. Carlos Escande

    Institut Pasteur de Montevideo, Uruguay

    Expertise
    Medicine
    Structural Biology and Molecular Biophysics
    Research focus
    atherosclerosis
    inflammatory diseases
    metabolism
    obesity
    type 2 diabetes
  13. Aaron Frank

    Arrakis Therapeutics, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Biochemistry and Chemical Biology
    Research focus
    molecular modeling
    biophysics
    structural biology
    computation
    RNA biochemistry
    RNA structural biology
  14. Adam Frost

    University of California, San Francisco, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Biochemistry and Chemical Biology
    Cell Biology
    Research focus
    cryo-EM
    electron cryo-microscopy
    membranes
    membrane remodeling
    proteostasis
    stress responses
    translation
    mitochondria
    nuclear envelope
    intracellular trafficking
  15. Teresa Giraldez

    Universidad de La Laguna, Spain

    Expertise
    Neuroscience
    Structural Biology and Molecular Biophysics
    Research focus
    ion channels
    neuronal excitability
    channelopathies
    Experimental organism
    mouse
  16. Marcel Goldschen-Ohm

    University of Texas at Austin, United States

    Expertise
    Neuroscience
    Structural Biology and Molecular Biophysics
    Research focus
    ion channel structure and mechanisms
    single molecule dynamics
    single molecule fluorescence
    patch-clamp electrophysiology
    ligand binding
  17. Ruben Gonzalez

    Columbia University, United States

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    translation
    translational control
    ribosomes
    RNA
    tRNA
    single-molecule biophysics
    single-molecule fluorescence resonance energy transfer
    cryo-EM
    biochemistry
    live cell imaging
    Experimental organism
    B. subtilis
    E. coli
    human
    S. cerevisiae
  18. Martin Graña

    Institut Pasteur de Montevideo, Uruguay

    Expertise
    Biochemistry and Chemical Biology
    Computational and Systems Biology
    Evolutionary Biology
    Physics of Living Systems
    Structural Biology and Molecular Biophysics
    Research focus
    protein 3D structure
    structural bioinformatics
    structure/function relationships
    evolution
  19. Nikolaus Grigorieff

    Janelia Research Campus, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Research focus
    cryo-EM methods
    image processing
    algorithms
    molecular mechanisms
    Experimental organism
    S. cerevisiae
    rotavirus
  20. Yogesh K Gupta

    The University of Texas Health Science Center at San Antonio, United States

    Expertise
    Medicine
    Structural Biology and Molecular Biophysics
    Cancer Biology
    Microbiology and Infectious Disease
    Research focus
    drug discovery
    nucleic acid modifications
    cancer epigenetics
    structures of viral proteins
    host-pathogen interactions
  21. Shozeb Haider

    University College London, United Kingdom

    Expertise
    Medicine
    Structural Biology and Molecular Biophysics
    Computational and Systems Biology
    Microbiology and Infectious Disease
    Research focus
    X-ray crystallography
    molecular dynamics simulations
    allostery
    structure-based drug design
    structural bioinformatics
    computational chemistry
    nucleic acids
    rare diseases
  22. Donald Hamelberg

    Georgia State University, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Research focus
    molecular dynamics
    classical simulations
    protein dynamics
    protein allostery
    enzyme catalysis
    Long time scale dynamics
  23. Heedeok Hong

    Michigan State University, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Biochemistry and Chemical Biology
    Research focus
    membrane proteins
    membrane protein folding
    membrane protein stability
    rhomboid proteases
    ATP-dependent proteolysis
    AAA+
    GlpG
    FtsH
  24. Leon D. Islas

    Universidad Nacional Autónoma de México, Mexico

    Expertise
    Structural Biology and Molecular Biophysics
    Research focus
    molecular computation
    membrane protein
    ion channels
    fluorescence
    models
  25. Andres Jara-Oseguera

    University of Texas at Austin, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Neuroscience
    Research focus
    ion channels
    Transient Receptor Potential (TRP) channels
    membrane transport proteins
    nociception
    voltage-activated channels
    cellular excitability
    pain-signaling
  26. Tatiana G Kutateladze

    University of Colorado School of Medicine, United States

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    epigenetics
    chromatin
    protein structure
    NMR spectroscopy
    molecular mechanisms
    Experimental organism
    human
  27. Joanne Lemieux

    University of Alberta, United States

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    protease
    intramembrane protease
    crystallography
    membrane proteins
    structural biology
  28. Richard Lewis

    Stanford University School of Medicine, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Research focus
    ion channels
    calcium signaling
  29. Chang Liu

    Johns Hopkins University, United States

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Microbiology and Infectious Disease
    Research focus
    coronavirus
    cryo-EM
    viral replication
    transcriptional regulation
    virus-host interactions
    RNA structure and processing
    ribonucleoprotein complex
  30. Andrei Lupas

    Max Planck Institute for Developmental Biology, Germany

    Expertise
    Biochemistry and Chemical Biology
    Computational and Systems Biology
    Structural Biology and Molecular Biophysics
    Evolutionary Biology
    Research focus
    bacterial surface proteins
    bioinformatics
    coiled coils
    protein design
    protein evolution
    protein structure
    transmembrane signal tranduction
  31. Mark T. Nelson

    The University of Vermont, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Neuroscience
    Research focus
    ion channels
    calcium signaling
    neurovascular coupling in the brain
    vascular, cell and systems biology
    Experimental organism
    mouse
  32. Hannes Neuweiler

    University of Würzburg, Germany

    Expertise
    Structural Biology and Molecular Biophysics
    Biochemistry and Chemical Biology
    Research focus
    protein folding
    protein dynamics
    protein engineering
    fluorescence spectroscopy
    fluorescence probes
    kinetics
    single-molecule fluorescence spectroscopy
  33. Stephan Pless

    University of Copenhagen, Denmark

    Expertise
    Structural Biology and Molecular Biophysics
    Biochemistry and Chemical Biology
    Research focus
    ion channels
    pharmacology
    electrophysiology
    biophysics
    chemical biology
    non-canonical amino acids
    protein engineering
    neurobiology
  34. Owen Pornillos

    University of Virginia, United States

    Expertise
    Microbiology and Infectious Disease
    Structural Biology and Molecular Biophysics
    Biochemistry and Chemical Biology
    Research focus
    higher-order assembly
    cell-free reconstitution
    retrovirus structure
    tripartite motif proteins
  35. Murali Prakriya

    Northwestern University, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Neuroscience
    Research focus
    cell imaging
    cellular electrophysiology
    calcium signaling
    ion channels
    neurobiology
    cell physiology
    Experimental organism
    mouse
  36. Arun Radhakrishnan

    University of Texas Southwestern Medical Center, United States

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Structural Biology and Molecular Biophysics
    Research focus
    lipid sensors
    cholesterol
    sphingomyelin
    cholesterol transport
    SREBP
    Scap
    cholesterol homeostasis
    endoplasmic reticulum
    Experimental organism
    E. coli
    human
    mouse
  37. Julien Roche

    Iowa State University, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Research focus
    protein folding
    intrinsically disordered proteins
    solution NMR spectroscopy
  38. Rina Rosenzweig

    Weizmann Institute of Science, Israel

    Expertise
    Structural Biology and Molecular Biophysics
    Research focus
    NMR
    protein folding
    chaperones
  39. Jon T Sack

    University of California, Davis, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Neuroscience
    Research focus
    ion channels
    voltage gating
    voltage clamp electrophysiology
    ligand binding
    allostery
    rate theory modeling
    thermodynamics
  40. Rajan Sankaranarayanan

    CSIR – Centre for Cellular and Molecular Biology, India

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    crystal structure
    mechanism
    translation of genetic code
    proofreading
    editing
    tRNA synthetase
    Experimental organism
    E. coli
  41. Sjors HW Scheres

    Medical Research Council Laboratory of Molecular Biology, United Kingdom

    Expertise
    Structural Biology and Molecular Biophysics
    Research focus
    cryo-EM
    maximum likelihood
    image processing
    amyloids
    tau
    alpha-synuclein
  42. Sang-Hee Shim

    Korea University, South Korea

    Expertise
    Structural Biology and Molecular Biophysics
    Research focus
    super-resolution optical microscopy
    in situ structural biology
    multiplexed microscopy
    spatial genome organization and dynamics
  43. Jungsan Sohn

    Johns Hopkins University School of Medicine, United States

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Immunology and Inflammation
    Microbiology and Infectious Disease
    Research focus
    innate immunity
    inflammasomes
    X-ray crystallography
    cryo-EM
    biochemistry
    enzyme kinetics
  44. Randy B Stockbridge

    University of Michigan, United States

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    ion channels
    transporters
    microbial membrane proteins
    crystallography
    electrophysiology
    Experimental organism
    E. coli
  45. Thomas Surrey

    The Francis Crick Institute, United Kingdom

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Structural Biology and Molecular Biophysics
    Research focus
    cytoskeleton
    spindle assembly
    cell division
    motor proteins
    microtubules
    self-organization
    active networks
    Experimental organism
    human
  46. Alan Talevi

    National University of La Plata, Argentina

    Expertise
    Biochemistry and Chemical Biology
    Computational and Systems Biology
    Microbiology and Infectious Disease
    Structural Biology and Molecular Biophysics
    Research focus
    bioinformatics
    drug discovery
    cheminformatics
    pharmacy
  47. Mohamed Trebak

    University of Pittsburgh School of Medicine, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Cell Biology
    Biochemistry and Chemical Biology
    Research focus
    calcium channels
    receptor signalling
    ion channel regulation
    vascular remodeling
    smooth muscle
  48. Julie P I Welburn

    University of Edinburgh, United Kingdom

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Structural Biology and Molecular Biophysics
    Research focus
    mitosis
    cytoskeleton
    motors
    phosphorylation
    kinase
    microtubule
    cilia
    kinetochore
    Experimental organism
    human
    in vitro
  49. Jie Xiao

    Johns Hopkins University, United States

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Chromosomes and Gene Expression
    Microbiology and Infectious Disease
    Physics of Living Systems
    Structural Biology and Molecular Biophysics
    Research focus
    single molecule biophysics
    microbiology
    cell division
    cell wall
    gene expression
    Experimental organism
    E. coli
  50. Bin Zhang

    Massachusetts Institute of Technology, United States

    Expertise
    Physics of Living Systems
    Structural Biology and Molecular Biophysics
    Research focus
    computational biophysics
    molecular dynamics
    chromatin organization
    biomolecular condensates
    genome folding
    coarse graining
  51. Lejla Zubcevic

    University of Kansas Medical Center, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Research focus
    ion channels
    membrane transport
    structural biology