Editors for Structural Biology and Molecular Biophysics

We aim to publish studies that advance our understanding of molecular mechanisms in biology, using experimental and computational approaches to provide quantitative insights. We also welcome studies describing structure determination by methods including cryoEM, crystallography and NMR, the investigation of macromolecular dynamics, the evolution of function and specificity in molecular systems, and the application of advanced biophysical methods to capture molecules in action. Read the latest research in this subject area.

Senior editors

  1. Richard Aldrich

    Richard Aldrich

    The University of Texas at Austin, United States

    Rick Aldrich is the Karl Folkers Chair II in Interdisciplinary Biomedical Research and Professor of Neuroscience at The University of Texas at Austin. He joined the faculty in 2006 and served as chair until 2011. Previously he was on the faculty of Neurobiology (1985-1990) and of Molecular and Cellular Physiology (1990-2006) at Stanford University where he served as department chair from 2001–2004. He was an investigator with the Howard Hughes Medical Institute from 1990 to 2006. His work is on molecular mechanisms of ion channels and calcium signaling proteins, with an emphasis on understanding gated conformational changes and allosteric mechanisms. Work in the laboratory is multidisciplinary including electrophysiology, biochemistry, spectroscopy, informatics and computation. He is a member of the National Academy of Science and the American Academy of Arts and Sciences, and is a Fellow of the American Association for the Advancement of Science and of the Biophysical Society. He is past president of the Biophysical Society and the Society of General Physiologists, and has received the Kenneth Cole Award for Membrane Physiology from the Biophysical Society and Alden Spencer Award for Neuroscience Research from Columbia University.

    Expertise
    Structural Biology and Molecular Biophysics
    Neuroscience
    Research focus
    ion channels
    calcium binding proteins
    membrane transport
    allostery and cooperativity
    cellular neurophysiology
    biochemical neuroscience
    Competing interests statement
    Richard Aldrich is employed by The University of Texas at Austin. He receives research funding from the National Institutes of Health. He is a member of the National Academy of Science and the American Academy of Arts and Sciences, and is a Fellow of the American Association for the Advancement of Science and of the Biophysical Society. He serves actively on the editorial boards of Proceedings of the National Academy of Sciences and The Journal of General Physiology.
  2. Olga Boudker

    Weill Cornell Medicine, United States

    Olga Boudker is an Associate Professor of Physiology and Biophysics at Weill Cornell Medicine and a Howard Hughes Medical Institute Investigator. Boudker's lab uses crystallography and cryo-EM to define the high-resolution structures of key functional states of transporters; single molecule FRET TIRF microscopy and NMR to probe their dynamics; biochemical approaches and isothermal titration calorimetry to probe their function and energetics; and bioinformatics to follow their evolution.

    Expertise
    Structural Biology and Molecular Biophysics
    Neuroscience
    Research focus
    membrane transporters
    membrane biology
    glutamate pumps
    membrane protein structure and function
    x-ray crystallography
  3. John Kuriyan

    John Kuriyan

    University of California, Berkeley, United States

    John Kuriyan is Professor of Molecular and Cell Biology and also of Chemistry at the University of California, Berkeley. Before this, he was on the faculty at The Rockefeller University, New York, where he began his career in 1987, leaving for Berkeley in 2001. Since 1990, he has been an Investigator of the Howard Hughes Medical Institute. Kuriyan completed undergraduate studies in chemistry at Juniata College, Huntingdon, PA. His doctoral research, on the dynamics of proteins, was carried out at MIT, under the guidance of Greg Petsko and Martin Karplus (Harvard University). Kuriyan’s research is aimed at understanding the structure and mechanism of the enzymes and molecular switches that carry out cellular signal transduction and DNA replication. His laboratory uses x-ray crystallography to determine the three-dimensional structures of proteins involved in signaling and replication, as well as biochemical, biophysical, and computational analyses to elucidate mechanisms. Kuriyan was elected to the US National Academy of Sciences in 2001.

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    protein science and biochemistry
    signaling
    crystallography
    electron microscopy
    modeling
    molecular dynamics
    Competing interests statement
    John Kuriyan has received funding from the Howard Hughes Medical Institute, the US National Institutes of Health, and the Leukemia and Lymphoma Society. He serves on the editorial board of the Proceedings of the National Academy of Sciences, and on the Scientific Advisory Boards of Carmot Therapeutics (San Francisco) and Jubilant Biosys (Bangalore). He is a founder of Nurix (San Francisco).
  4. Kenton J Swartz

    National Institute of Neurological Disorders and Stroke, NIH, United States

    Kenton Swartz has been a Senior Investigator in the National Institute of Neurological Disorders and Stroke within the National Institutes of Health in Bethesda, Maryland since 2003. He obtained a BS in Chemistry and Biology from Eastern Mennonite College in 1986 and a PhD in Neurobiology from Harvard Medical School in 1993, where he worked with Bruce Bean studying the regulation of voltage-gated calcium channels by G-proteins and protein kinases. He obtained postdoctoral training with Roderick MacKinnon at Harvard Medical School, where he began isolating and studying toxins that interact with voltage-activated potassium channels. His laboratory uses biochemical, molecular biological, biophysical and structural techniques to understand how ion channel proteins sense critical biological stimuli, including membrane voltage, temperature, and both chemical and mechanical signals. He received an NIH Directors Award for Scientific Achievement in 2008, an NIH Office of the Director Honor Award on behalf of the Diversity Task Force in 2011 and the Kenneth S. Cole Award from the Biophysical Society in 2017. He has also served as the president of the Society of General Physiologists.

    Expertise
    Structural Biology and Molecular Biophysics
    Neuroscience
    Research focus
    ion channel proteins as molecular sensors
    voltage-activated ion channels
    Transient Receptor Potential (TRP) channels
    ATP-activated P2X receptor channels
    Mechanosensitive ion channels
    Competing interests statement
    Kenton Swartz is employed by the Intramural Research Program of the National Institute of Neurological Disorders and Stroke, National Institutes of Health. In addition to serving as a Senior Editor at eLife, he has served as a Reviewing Editor for eLife and as an Associate Editor at the Journal of General Physiology. He also teaches yoga at LifeTime Athletic.
  5. Cynthia Wolberger

    Johns Hopkins University School of Medicine, United States

    Cynthia Wolberger is a Professor of Biophysics and Biophysical Chemistry at the Johns Hopkins University School of Medicine, whose faculty she joined in 1991. She received her AB in Physics from Cornell University and her PhD in Biophysics from Harvard University, where she did thesis work on the structural basis of protein-DNA interactions under the guidance of Steve Harrison and Mark Ptashne. After a postdoctoral fellowship at the University of California, San Francisco with Bob Stroud, she worked on the crystal structures of homeodomain-DNA complexes in the laboratory of Carl Pabo at Johns Hopkins. Her earlier worked focused on the structural basis for combinatorial regulation of gene expression and the molecular mechanisms of the sirtuin family of protein deacetylases. Her current research centers on the mechanisms by which ubiquitin plays a signaling role in transcription and the DNA damage response. Wolberger was a recipient of the David and Lucile Packard Fellowship for Science and Engineering, a March of Dimes–Basil O’Conor Starter Scholar Award, and an American Cancer Society Junior Faculty Award, and was a Howard Hughes Medical Institute Investigator from 1994–2014. She received the Protein Society’s Dorothy Crowfoot Hodgkin Award and is a Fellow of the American Association for the Advancement of Science.

    Expertise
    Structural Biology and Molecular Biophysics
    Chromosomes and Gene Expression
    Biochemistry and Chemical Biology
    Research focus
    x-ray crystallography
    enzymology
    transcriptional regulation
    ubiquitin signaling
    Competing interests statement
    Cynthia Wolberger receives funding from the National Institutes of Health and the US–Israel Binational Science Foundation. She chairs the Scientific Advisory Committee of the RCSB Protein Data Bank and is on the external scientific advisory boards of the Advanced Photon Source and the Max Planck Institute for Biochemistry in Martinsried, Germany. She is a member of the Editorial Advisory Board of Protein Science, the Editorial Boards of Structure and Current Opinion in Structural Biology, and is a Faculty of 1000 section head in Transcription and Translation. Wolberger is also a member of the Scientific Advisory Board of Thermo Fisher Scientific.

Reviewing editors

  1. Patricia Bassereau

    Institut Curie, France

    Expertise
    Structural Biology and Molecular Biophysics
    Cell Biology
    Physics of Living Systems
    Research focus
    membrane mechanics
    membrane trafficking
    endocytosis
    in vitro reconstituted membrane systems
    membrane curvature
    filopodia
    membrane organization
  2. Nir Ben-Tal

    Tel Aviv University, Israel

    Expertise
    Structural Biology and Molecular Biophysics
    Computational and Systems Biology
    Research focus
    structural bioinformatics
    structure, function and motion in membrane proteins
    protein interactions
  3. James Berger

    Johns Hopkins University School of Medicine, United States

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    x-ray crystallography
    electron microscopy
    biochemistry
    biophysics
    DNA replication
    ATPase mechanism
    DNA topology
    topoisomerases
    helicases
    Experimental organism
    B. subtilis
    D. melanogaster
    E. coli
    human
    S. cerevisiae
  4. Richard M Berry

    University of Oxford, United Kingdom

    Expertise
    Structural Biology and Molecular Biophysics
    Research focus
    rotary molecular motors
    bacterial flagellar motor
    ATP synthase
    single-molecule methods
    Experimental organism
    E. coli
  5. Pamela Bjorkman

    California Institute of Technology, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Immunology and Inflammation
    Research focus
    structural biology
    antibody-antigen interactions
    rapidly-mutating viruses
    immunogen design
  6. Axel A Brakhage

    Leibniz Institute for Natural Product Research and Infection Biology (HKI), Germany

    Expertise
    Microbiology and Infectious Disease
    Structural Biology and Molecular Biophysics
    Research focus
    infection biology of fungi
    microbial secondary metabolism
    microbial communication
    biotechnology
    transcription factors
    macrophages
    neutrophils
    Experimental organism
    Aspergillus
    M. xanthus
    Streptomyces
  7. Axel T Brunger

    Stanford University, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Neuroscience
    Research focus
    neurotransmitter release
    membrane fusion
    signaling
    structural biology
    computational biology
    Experimental organism
    mouse
  8. Andrew Carter

    MRC Laboratory of Molecular Biology (Cambridge), United Kingdom

    Expertise
    Structural Biology and Molecular Biophysics
    Research focus
    x-ray crystallography
    cryo-electron microscopy
    advanced single molecule techniques
    structural studies of dynein
  9. Baron Chanda

    University of Wisconsin - Madison, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Neuroscience
    Research focus
    ion channels
    voltage-gating
    ligand-activation
    allosteric signaling
    single channel electrophysiology
    single molecule fluorescence spectroscopy
    voltage clamp fluorometry
  10. Laszlo Csanady

    Semmelweis University, Hungary

    Expertise
    Structural Biology and Molecular Biophysics
    Research focus
    ion channels
    structure
    gating
    CTFR
    TPRM2
    cystic fibrosis
    Experimental organism
    E. coli
    X. laevis oocytes
    HEK-293 cells
  11. Cynthia M Czajkowski

    University of Wisconsin, Madison, United States

    Expertise
    Neuroscience
    Structural Biology and Molecular Biophysics
    Research focus
    ligand-gated ion channels
    structure-function
    drug modulation
  12. Sebastian Deindl

    Uppsala University, Sweden

    Expertise
    Structural Biology and Molecular Biophysics
    Chromosomes and Gene Expression
    Research focus
    Single-molecule biophysics and structural biology
    chromatin remodeling machines
    chromatin remodeling
    helicases
    Experimental organism
    E. coli
    human
    S. cerevisiae
  13. Volker Dötsch

    Goethe University, Germany

    Expertise
    Structural Biology and Molecular Biophysics
    Cell Biology
    Research focus
    membrane proteins
    signal transduction
  14. Edward Egelman

    University of Virginia, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Research focus
    cryo-EM
    helical polymers
    Experimental organism
    E. coli
    human
    viruses
  15. Jose Faraldo-Gomez

    National Heart, Lung and Blood Institute, National Institutes of Health, United States

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    Computational biophysics
    molecular computation
    membrane proteins
  16. Sarel Fleishman

    Weizmann Institute of Science, Israel

    Expertise
    Computational and Systems Biology
    Structural Biology and Molecular Biophysics
    Research focus
    molecular recognition
    computational protein design
    protein folding
  17. Lucy Forrest

    National Institute of Neurological Disorder and Stroke, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Research focus
    protein structure prediction
    secondary active transporters
    membrane proteins
    molecular simulations
  18. Adam Frost

    University of California, San Francisco, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Biochemistry and Chemical Biology
    Cell Biology
    Research focus
    cryo-EM
    electron cryo-microscopy
    membranes
    membrane remodeling
    proteostasis
    stress responses
    translation
    mitochondria
    nuclear envelope
    intracellular trafficking
  19. Nikolaus Grigorieff

    Janelia Research Campus, United States

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    structural biology
    image processing
    biophysics
    electron microscopy
    cryo-EM
  20. Taekjip Ha

    HHMI, Johns Hopkins University School of Medicine, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Research focus
    single molecule biophysics
    chromatin biophysics
    mechanobiology
    DNA-protein interactions
    DNA motor proteins
    Experimental organism
    human cells
    E. coli
  21. Franz-Ulrich Hartl

    Max Planck Institute of Biochemistry, Germany

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    protein folding
    molecular chaperones
    neurodegenerative disorders
  22. Manajit Hayer-Hartl

    Max Planck Institute of Biochemistry, Germany

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    molecular chaperones
    protein folding and assembly
    protein misfolding and aggregation
    molecular machines
  23. Leon D. Islas

    Universidad Nacional Autónoma de México, Mexico

    Expertise
    Structural Biology and Molecular Biophysics
    Research focus
    molecular computation
    membrane proteins
    ion channels
    fluorescence
    models
  24. Frank Jülicher

    Max Planck Institute for the Physics of Complex Systems, Germany

    Expertise
    Structural Biology and Molecular Biophysics
    Physics of Living Systems
    Research focus
    active cellular processes
    physics of the cytoskeleton and motor proteins
    physics of cell division
    tissues and developmental processes
    biophysics of hearing
  25. Lewis Kay

    University of Toronto, Canada

    Expertise
    Structural Biology and Molecular Biophysics
    Research focus
    NMR spectroscopy
    Experimental organism
    human
  26. Werner Kühlbrandt

    Max Planck Institute for Biophysics, Germany

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Cell Biology
    Research focus
    membrane protein structure and function
    membrane transporters
    macromolecular complexes
    molecular bioenergetics
    membrane proteins
    cryo-EM
    Experimental organism
    E. coli
    S. cerevisiae
  27. Richard Lewis

    Stanford University School of Medicine, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Research focus
    ion channels
    calcium signaling
  28. Andrei Lupas

    Max Planck Institute for Developmental Biology, Germany

    Expertise
    Computational and Systems Biology
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    bacterial surface proteins
    bioinformatics
    coiled coils
    protein design
    protein evolution
    protein structure
    transmembrane signal tranduction
  29. Andreas Martin

    University of California, Berkeley, United States

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    AAA+ ATPases
    protein degradation
    proteostasis
    ATPase mechanism
    protein folding
  30. Geeta Narlikar

    University of California, San Francisco, United States

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    chromatin
    heterochromatin spread
    chromatin remodeling machines
  31. Mark T. Nelson

    The University of Vermont, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Neuroscience
    Research focus
    ion channels
    calcium signaling
    neurovascular coupling in the brain
    vascular, cell and systems biology
    Experimental organism
    mouse
  32. Hannes Neuweiler

    University of Würzburg, Germany

    Expertise
    Structural Biology and Molecular Biophysics
    Biochemistry and Chemical Biology
    Research focus
    protein dynamics
    protein folding
    protein engineering
    fluorescence spectroscopy
    fluorescence probe development
    single-molecule fluorescence spectroscopy
    kinetics
    Experimental organism
    E. coli
  33. Anna Pyle

    Yale University, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Research focus
    RIG-I like receptors
    innate immunity
    antiviral signaling
    helicases
    group II intron
    vaccine adjuvants
    RNA design
    computational modeling
    RNA structure
    Experimental organism
    human
    mouse
    viruses
  34. Arun Radhakrishnan

    University of Texas Southwestern Medical Center, United States

    Expertise
    Biochemistry and Chemical Biology
    Cell Biology
    Structural Biology and Molecular Biophysics
    Research focus
    lipid sensors
    cholesterol
    sphingomyelin
    cholesterol transport
    SREBP
    Scap
    cholesterol homeostasis
    endoplasmic reticulum
    Experimental organism
    E. coli
    human
    mouse
  35. Samara L Reck-Peterson

    University of California San Diego, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Cell Biology
    Research focus
    cytoskeleton
    intracellular transport
    microtubules
    actin
    dynein
    kinesin
    myosin
    Experimental organism
    S. cerevisiae
    Aspergillus
    human
  36. Sjors HW Scheres

    Medical Research Council Laboratory of Molecular Biology, United Kingdom

    Expertise
    Structural Biology and Molecular Biophysics
    Research focus
    cryo-electron microscopy
    image processing
    Alzheimer's disease
    tau
    amyloid
    helical reconstruction
    maximum likelihood
    Experimental organism
    human
  37. Yibing Shan

    DE Shaw Research, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Computational and Systems Biology
    Research focus
    computational structural biology
    signaling
    computational chemistry
    molecular dynamics
    computer-aided drug design
  38. Maria Spies

    University of Iowa, United States

    Expertise
    Chromosomes and Gene Expression
    Structural Biology and Molecular Biophysics
    Research focus
    single-molecule biophysics
    protein-nucleic acid interactions
    DNA repair
    replication
    homologous recombination
    biophysics of drug discovery
    Experimental organism
    E. coli
    human
    S. cerevisiae
  39. Sriram Subramaniam

    University of British Columbia, Canada

    Expertise
    Structural Biology and Molecular Biophysics
    Research focus
    cryo-electron microscopy
    protein structure
    HIV entry
    correlative light and electron microscopy
    electron tomography
    automated image processing
  40. Wesley Sundquist

    University of Utah School of Medicine, United States

    Expertise
    Structural Biology and Molecular Biophysics
    Microbiology and Infectious Disease
    Biochemistry and Chemical Biology
    Research focus
    virus assembly
    HIV
    ESCRT
    abscission
    innate immunity
  41. Thomas Surrey

    The Francis Crick Institute, United Kingdom

    Expertise
    Cell Biology
    Computational and Systems Biology
    Structural Biology and Molecular Biophysics
    Research focus
    cytoskeleton
    microtubules
    motor proteins
    self-organization
    cell division
    mitotic spindle
    in vitro reconstitution
    fluorescence microscopy
    Experimental organism
    human
    Xenopus
  42. Oliver Weichenrieder

    Max Planck Institute for Developmental Biology, Germany

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Genetics and Genomics
    Research focus
    retrotransposition
    regulatory mRNA
    x-ray crystallography
    structural biology
  43. William I Weis

    Stanford University, United States

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    cell adhesion
    wnt signaling
    x-ray crystallography
    structural biology
    Experimental organism
    C. elegans
    Dictyostelium
    human
    mouse
  44. Claire Wyart

    Institut du Cerveau et la Moelle épinière, France

    Expertise
    Neuroscience
    Structural Biology and Molecular Biophysics
    Research focus
    spinal cord
    hindbrain
    midbrain
    sensory systems
    motor systems
    Experimental organism
    zebrafish
    mouse
    macaque
  45. Gary Yellen

    Harvard Medical School, United States

    Expertise
    Neuroscience
    Structural Biology and Molecular Biophysics
    Research focus
    neuronal metabolism and excitability
    fluorescent biosensors
    ion channels
  46. Mingjie Zhang

    Hong Kong University of Science and Technology, Hong Kong SAR China

    Expertise
    Biochemistry and Chemical Biology
    Structural Biology and Molecular Biophysics
    Research focus
    postsynaptic density
    synaptic signaling
    scaffold proteins
    liquid-liquid phase separation
    biological condensates