Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Structural Biology and Molecular Biophysics

    Yoda molecules agonize PIEZO2

    Tharaka D Wijerathne, Aneesh Chandrasekharan ... Jérôme J Lacroix
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    Structural insights into peptidoglycan hydrolysis by the FtsEX system in Escherichia coli during cell division

    Jianwei Li, Yutong He ... Min Luo
    Structural and biochemical analyses reveal how E. coli FtsEX accommodates EnvC asymmetry to regulate amidase activation during bacterial cell division.
    1. Structural Biology and Molecular Biophysics

    Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching

    Kexin Zhang, Timothy Grant, Nikolaus Grigorieff
    High-resolution structural information can be recovered from proteins well below the conventional cryo-electron microscopy size range, substantially extending the range of complexes accessible to structural analysis.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Synaptic Organization of Surface AMPARs Changes by Brain Region and Tauopathy

    Rohit M Vaidya, Jiahao Zhang ... Paul R Selvin
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A Sterol-Binding Cavity Underlies Sterol Recognition and Differential Activation of the ABCG5/G8

    Fatemeh Rezaei, Isra F Omar ... Jyh-Yeuan Lee
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A proteome-wide biochemical screen defines binding determinants of the core autophagy protein LC3B

    Jennifer Kosmatka, Cong Liu ... Amy E Keating
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Phosphorylation and pocket-binding ligands rewire the coupled networks in multidomain protein condensate

    Yu Cao, Jinyu Chen, Xiakun Chu
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    Large-scale prospective evaluation of co-folding across hundreds of Mac1–ligand complexes and three virtual screens

    Jongbin Kim, Galen J Correy ... James S Fraser
    Co-folding methods accurately place and rank ligands within an optimization series, yet fail to separate true binders from docking false positives, suggesting complementary roles in drug discovery.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Product-stabilized filamentation by human glutamine synthetase allosterically tunes metabolic activity

    Eric Greene, Richard Muniz ... James S Fraser
    Glutamine drives its own synthetase to assemble into inhibitory filaments, linking product concentration directly to a conformational switch that gates the active site.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structures of LolB bound to LolA or lipoprotein resolve the final steps of bacterial lipoprotein trafficking

    Abigail E Jepson, Elise Kaplan ... Vassilis Koronakis
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
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Highlights

    1. Structural Biology and Molecular Biophysics

    Glycobiology: How enzymes make the right choice during biosynthesis

    Ana S Ramírez, Camilo Perez
    1. Structural Biology and Molecular Biophysics

    Membrane Biology: Two binding sites are better than one

    Mackenzie K Scott, John E Burke
    1. Structural Biology and Molecular Biophysics

    Membrane Proteins: A missing link for efflux pumps

    Hilal Wehbi, Isabelle Broutin

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Merritt Maduke
    Stanford University School of Medicine, United States
  3. Kenton J Swartz
    National Institute of Neurological Disorders and Stroke, NIH, United States
  4. See more editors