Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife publishes research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanism of Ca2+ transport by ferroportin

    Jiemin Shen, Azaan Saalim Wilbon ... Yaping Pan
    Cryo-EM structure and functional analyses show that human iron exporter ferroportin (Fpn) can bind and transport calcium ions and the transport activity is reduced when the concentration of ferrous ions is high.
    1. Structural Biology and Molecular Biophysics

    Inhibition of the proton-activated chloride channel PAC by PIP2

    Ljubica Mihaljević, Zheng Ruan ... Zhaozhu Qiu
    PIP2 inhibits the proton-activated chloride (PAC) channel by selectively stabilizing its desensitized state.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structures of human dynein in complex with the lissencephaly 1 protein, LIS1

    Janice M Reimer, Morgan E DeSantis ... Andres E Leschziner
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Improved ANAP incorporation and VCF analysis reveal details of P2X7 current facilitation and a limited conformational interplay between ATP binding and the intracellular ballast domain

    Anna Durner, Ellis Durner, Annette Nicke
    Comparision of current and fluorescent kinetics from P2X7 receptor mutants labeled with the fluorescent amino acid ANAP suggests that the characteristic P2X7 current facilitation involves changes in channel gating rather than interactions or conformational changes of its intracellular ballast domain.
    1. Structural Biology and Molecular Biophysics

    A mechanism of uncompetitive inhibition of the serotonin transporter

    Shreyas Bhat, Ali El-Kasaby ... Walter Sandtner

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Nancy Carrasco
    Vanderbilt University School of Medicine, United States
  3. Volker Dötsch
    Goethe University, Germany
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