Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Structural Biology and Molecular Biophysics

    Membrane Proteins: A missing link for efflux pumps

    Hilal Wehbi, Isabelle Broutin
    A lipoprotein called YbjP could be the answer to a puzzle about efflux pumps in gram-negative bacteria.
    Version of Record
    Insight
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    The spike tip protein of bacteriophage T4

    Yves Mattenberger, Ekaterina S Knyazhanskaya ... Dominique Belin
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Dynamic Architecture of Mycobacterial Outer Membranes Revealed by All-Atom Simulations

    Turner P Brown, Matthieu Chavent, Wonpil Im
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Adaptor protein supersaturation drives innate immune signaling and cell fate

    Alejandro Rodriguez Gama, Tayla Miller ... Randal Halfmann
    In-cell biophysical analyses identify a sequence-encoded energy storage function of innate immune adaptor proteins that allows cells to respond quickly and decisively to pathogenic signals.
    1. Structural Biology and Molecular Biophysics

    A Structural Code for Assembly Specificity in GID/CTLH-Type E3 Ligases

    Pia Maria van gen Hassend, Hermann Schindelin
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Large scale prospective evaluation of co-folding across 557 Mac1-ligand complexes and three virtual screens

    Jongbin Kim, Galen J Correy ... James S Fraser
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Convincing
    1. Structural Biology and Molecular Biophysics

    A lipoprotein partner for the Escherichia coli outer membrane protein TolC

    Jim Horne, Elise Kaplan ... Ben F Luisi
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Insights into substrate binding and utilization by hyaluronan synthase

    Zachery Stephens, Julia Karasinska, Jochen Zimmer
    Complementary biochemical and structural findings reveal molecular principles underlying substrate selectivity by a model hyaluronan synthase.
    1. Structural Biology and Molecular Biophysics

    Interaction hierarchy among Cdv proteins drives recruitment to membrane necks

    Nicola De Franceschi, Alberto Blanch-Jover, Cees Dekker
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Rescuing the Function of Missense-Mutated Tumor Suppressor VHL using Stabilizing Small Molecules

    Mariam Ahmed Fouad, Christopher S Parry ... John Karanicolas
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
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Highlights

    1. Structural Biology and Molecular Biophysics

    A missing link for efflux pumps

    Hilal Wehbi, Isabelle Broutin
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Modelling biomolecular condensates

    Furqan Dar, Rohit Pappu

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Felix Campelo
    Pompeu Fabra University, Spain
  3. Qiang Cui
    Boston University, United States
  4. See more editors