Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife publishes research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Structural Biology and Molecular Biophysics

    Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and nonischemic human hearts

    Maicon Landim-Vieira et al.
    Analytical techniques and computational models reveal novel post-translational modifications on β-myosin heavy chain in the human hearts and highlight their potential as therapeutic targets.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Doublecortin engages the microtubule lattice through a cooperative binding mode involving its C-terminal domain

    Atefeh Rafiei et al.
    Doublecortin activates its C-terminal domain when its N-terminal domain engages the microtubule lattice, leading to self-associations that explain the stabilizing effect of Doublecortin in neuronal migration.
    1. Structural Biology and Molecular Biophysics

    Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane

    Siyoung Kim et al.
    The functions of seipin in triacylglycerol nucleation and lipid droplet maturation are studied with all-atom and coarse-grained simulations along with cell experiments, providing a novel model for lipid droplet formation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Rate-limiting transport of positively charged arginine residues through the Sec-machinery is integral to the mechanism of protein secretion

    William J Allen et al.
    The time it takes to secrete a protein is dominated by diffusion of positively charged arginines through the channel across the membrane, but lysines avoid this problem as they are neutralised before transport.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Allosteric cooperation in β-lactam binding to a non-classical transpeptidase

    Nazia Ahmad et al.
    Allosteric mechanism of dual β-lactam binding in L,D-transpeptidase from Mycobacterium tuberculosis.
    1. Structural Biology and Molecular Biophysics

    Ligand binding remodels protein side-chain conformational heterogeneity

    Stephanie A Wankowicz et al.
    Protein conformational heterogeneity changes upon ligand binding are influenced by ligand properties and can modulate the free energy of binding.

Senior editors

  1. Richard Aldrich
    Richard Aldrich
    The University of Texas at Austin, United States
  2. Philip Cole
    Harvard Medical School, United States
  3. José Faraldo-Gómez
    National Institutes of Health, United States
  4. See more editors