Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife publishes research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Structural Biology and Molecular Biophysics

    Ancestral acetylcholine receptor β-subunit forms homopentamers that prime before opening spontaneously

    Christian JG Tessier et al.
    Reconstructed ancestral muscle-type acetylcholine receptor β-subunits readily form homopentameric ion channels that open spontaneously, and display functional hallmarks of the modern-day heteropentameric receptor despite being devoid of canonical agonist-binding sites.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    ATP binding facilitates target search of SWR1 chromatin remodeler by promoting one-dimensional diffusion on DNA

    Claudia C Carcamo et al.
    In vitro single-particle tracking reveals that ATP binding increases the one-dimensional diffusion of yeast chromatin remodeler SWR1 on DNA stretched between optical tweezers and diffusion is confined by protein roadblocks and nucleosomes.
    1. Structural Biology and Molecular Biophysics

    Multistep loading of a DNA sliding clamp onto DNA by replication factor C

    Marina Schrecker et al.
    Single-particle cryo-EM structures reveal a multistep process of how DNA is loaded into the DNA sliding clamp proliferating cell nuclear antigen by the canonical clamp loader replication factor C.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Lactoferricins impair the cytosolic membrane of Escherichia coli within a few seconds and accumulate inside the cell

    Enrico F Semeraro et al.
    The damage of the bacterial cell envelope is found to be only a secondary effect of the antimicrobial activity of lactoferricin derivatives.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Structural motifs for subtype-specific pH-sensitive gating of vertebrate otopetrin proton channels

    Bochuan Teng et al.
    The sour receptor, OTOP1, and related proton channel OTOP3 are steeply activated by extracellular protons while OTOP2 is active over a broad pH range and differences in gating are partly attributed to extracellular domains.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    A nucleation barrier spring-loads the CBM signalosome for binary activation

    Alejandro Rodriguez Gama et al.
    Switches in cell state downstream of pathogen exposure are driven by a deeply conserved disorder-to-order phase transition in an immunity signaling network.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    µ-Theraphotoxin Pn3a inhibition of CaV3.3 channels reveals a novel isoform-selective drug binding site

    Jeffrey R McArthur et al.
    The spider venom peptide Pn3a recognizes a pharmacophore unique to CaV3.3 amongst T-type calcium channels, underscoring its potential as a novel molecular tool for the study of CaV3.3-mediated currents in native cells.

Senior editors

  1. Richard Aldrich
    Richard Aldrich
    The University of Texas at Austin, United States
  2. Amy H Andreotti
    Iowa State University, United States
  3. Nancy Carrasco
    Vanderbilt University School of Medicine, United States
  4. See more editors