Structural Biology and Molecular Biophysics

Latest articles

1. 1. Structural Biology and Molecular Biophysics

   Conduction pathway for potassium through the E. coli pump KdpFABC

   Adel Hussein, Xihui Zhang ... David L Stokes
2. 1. Structural Biology and Molecular Biophysics

   DIRseq as a method for predicting drug-interacting residues of intrinsically disordered proteins from sequences

   Matt MacAinsh, Sanbo Qin, Huan-Xiang Zhou

   A sequence-based method, DIRseq, has been developed to predict drug-interacting residues of intrinsically disordered proteins.
3. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Pleomorphic effects of three small-molecule inhibitors on transcription elongation by Mycobacterium tuberculosis RNA polymerase

   Omar Herrera-Asmat, Alexander B Tong ... Carlos Bustamante
4. 1. Structural Biology and Molecular Biophysics

   Protein-Induced Membrane Strain Drives Supercomplex Formation

   Maximilian C Pöverlein, Alexander Jussupow ... Ville RI Kaila
5. 1. Structural Biology and Molecular Biophysics

   Ω-Loop mutations control dynamics of the active site by modulating the hydrogen-bonding network in PDC-3 β-lactamase

   Shuang Chen, Andrew R Mack ... Shozeb Haider
6. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Product-stabilized filamentation by human glutamine synthetase allosterically tunes metabolic activity

   Eric Greene, Richard Muniz ... James S Fraser
7. 1. Neuroscience
   2. Structural Biology and Molecular Biophysics

   The molecular infrastructure of glutamatergic synapses in the mammalian forebrain

   Julia Peukes, Charlie Lovatt ... René AW Frank

   CryoCLEM-guided cryoET of Psd95-GFP knockin mouse tissue and ultra-fresh synaptonerosomes indicate that the postsynaptic density is a not a conserved feature of glutamatergic synapses in the mouse brain.
8. 1. Structural Biology and Molecular Biophysics

   Enzyme Dynamics: Capturing enzymes in motion

   Álvaro de la Gándara, Agnieszka A Kendrick

   A combination of cryogenic electron microscopy and molecular simulations has been used to study the structure and dynamics of an enzyme called ACE.
9. 1. Structural Biology and Molecular Biophysics

   Conformational changes, excess area, and elasticity of the Piezo protein-membrane nanodome from coarse-grained and atomistic simulations

   Sneha Dixit, Frank Noé, Thomas R Weikl

   Piezo proteins induce a curved protein-membrane nanodome with an excess area of about 40 nm² in tensionless membranes and resist tension-induced flattening with a force constant of about 60 pN/nm.
10. 1. Structural Biology and Molecular Biophysics

    Dimerization and dynamics of human angiotensin-I converting enzyme revealed by cryo-EM and MD simulations

    Jordan M Mancl, Xiaoyang Wu ... Wei-Jen Tang

    Structural and computational approaches uncover the molecular basis for dimerization, open-closed conformational transitions, and the dynamic behavior of the human angiotensin-I converting enzyme dimer.