Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    CryoEM structures of Kv1.2 potassium channels, conducting and non-conducting

    Yangyu Wu, Yangyang Yan ... Fred J Sigworth
    The well-studied Kv1.2 potassium ion channel is observed in a variety of states and conditions, to understand mechanisms of ion permeation, gating and block.
    1. Structural Biology and Molecular Biophysics

    Mechanism of dimer selectivity and binding cooperativity of BRAF inhibitors

    Joseph Clayton, Aarion Romany ... Jana Shen
    BRAF inhibitors achieve monomer or dimer selectivity through their ability to modulate dimerization and allosteric communication.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Compound Mutations in the Abl1 Kinase Cause Inhibitor Resistance by Shifting DFG Flip Mechanisms and Relative State Populations

    Gabriel Monteiro da Silva, Kyle Lam ... Brenda M Rubenstein
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of METTL3-METTL14 with an m6A nucleotide reveals insights into m6A conversion and sensing

    Shan Qi, Abhay Kumar ... Yogesh K Gupta
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics

    Flexibility in PAM recognition expands DNA targeting in xCas9

    Kazi A Hossain, Lukasz Nierzwicki ... Giulia Palermo
    xCas9's ability to recognise diverse DNA sequences stems from structural flexibility in the protospacer adjacent motif (PAM)-interacting cleft and adaptability to PAM-induced conformational changes, paving the way for advanced genome editing tools.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Mapping HIV-1 RNA Structure, Homodimers, Long-Range Interactions and persistent domains by HiCapR

    Yan Zhang, Jingwan Han ... Zhihu Zhao
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Interpretable Protein-DNA Interactions Captured by Structure-Sequence Optimization

    Yafan Zhang, Irene Silvernail ... Xingcheng Lin
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody

    Joar Esteban Pinto Torres, Mathieu Claes ... Yann G.-J Sterckx
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics

    Conformational changes, excess area, and elasticity of the Piezo protein-membrane nanodome from coarse-grained and atomistic simulations

    Sneha Dixit, Frank Noé, Thomas R Weikl
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter

    Parveen Goyal, KanagaVijayan Dhanabalan ... Subramanian Ramaswamy
    The first structure of a Neu5Ac bound Tripartite ATP-independent Periplasmic transporter (TRAP) reveals the presence of three ion binding sites.
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Highlights

    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Modelling biomolecular condensates

    Furqan Dar, Rohit Pappu
    1. Structural Biology and Molecular Biophysics

    Same structure, different mechanisms?

    Francis TF Tsai, Christopher P Hill

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Felix Campelo
    The Institute of Photonic Sciences, Spain
  3. Merritt Maduke
    Stanford University School of Medicine, United States
  4. See more editors