Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife publishes research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3′ end biogenesis

    Lena Maria Muckenfuss, Anabel Carmen Migenda Herranz ... Martin Jinek
    Molecular details of the interactions of human Fip1 with CPSF30 and CstF77 unravel key aspects of mRNA polyadenylation and its regulation.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    The giant mimivirus 1.2 Mb genome is elegantly organized into a 30-nm diameter helical protein shield

    Alejandro Villalta, Alain Schmitt ... Chantal Abergel
    As a Russian doll, mimivirus dsDNA genome is folded in a nucleocapsid-like structure enclosed in the nucleoid compartment, encased in the icosahedral capsid itself decorated by long glycosylated fibrils surprisingly made of the same protein as the genomic fiber.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural insight on the mechanism of an electron-bifurcating [FeFe] hydrogenase

    Chris Furlan, Nipa Chongdar ... James A Birrell
    Cryo-EM and particle classification techniques reveal how the electron-bifurcating [FeFe] hydrogenase from Thermotoga maritima multimerizes to connect distant active sites and reveal different conformational states that enable catalysis.
    1. Structural Biology and Molecular Biophysics

    Structures of topoisomerase V in complex with DNA reveal unusual DNA-binding mode and novel relaxation mechanism

    Amy Osterman, Alfonso Mondragón
    Structural and biochemical studies explain the topoisomerase V DNA relaxation mechanism by showing that it adopts an unusual conformation when bound to DNA that exposes the active site.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission

    Dawn M Wenzel, Douglas R Mackay ... Wesley I Sundquist
    A comprehensive, quantitative, protein-protein interaction screen maps the network of interactions between human MIT domains and ESCRT-III C-terminal tails, and reveals MIT domain-containing protein cofactors for abscission and the 'No Cut' abscission checkpoint.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of Geobacter OmcZ filaments suggests extracellular cytochrome polymers evolved independently multiple times

    Fengbin Wang, Chi Ho Chan ... Daniel R Bond
    A cryo-EM structure of the bacterial OmcZ cytochrome filament provides evidence for the possibility that cytochrome polymers had multiple origins in bacteria.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Membrane-mediated dimerization potentiates PIP5K lipid kinase activity

    Scott D Hansen, Albert A Lee ... Jay T Groves
    Dimerization promotes nonlinear kinetics in PIP5K-dependent lipid phosphorylation reactions.
    1. Structural Biology and Molecular Biophysics

    Mars, a molecule archive suite for reproducible analysis and reporting of single-molecule properties from bioimages

    Nadia M Huisjes, Thomas M Retzer ... Karl E Duderstadt
    Mars provides a software platform for the development of complex single-molecule analysis workflows enabling the discovery and reporting of new biological phenomena with an open data format accessible to everyone.
    1. Structural Biology and Molecular Biophysics

    Unfolding and identification of membrane proteins in situ

    Nicola Galvanetto, Zhongjie Ye ... Vincent Aldo Torre

Senior editors

  1. Richard Aldrich
    Richard Aldrich
    The University of Texas at Austin, United States
  2. Amy H Andreotti
    Iowa State University, United States
  3. Nancy Carrasco
    Vanderbilt University School of Medicine, United States
  4. See more editors