Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Structural Biology and Molecular Biophysics

    p53 isoforms have a high aggregation propensity, interact with chaperones and lack binding to p53 interaction partners

    Anamari Brdar, Christian Osterburg ... Volker Dötsch
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics

    RNA tertiary structure and conformational dynamics revealed by BASH MaP

    Maxim Oleynikov, Samie R Jaffrey
    BASH MaP quantitatively reveals alternative RNA tertiary structures by enabling dimethyl sulfate to probe the presence of nucleobase interactions on the Watson-Crick and Hoogsteen faces of single RNA molecules.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Discovery of a Heparan Sulfate Binding Domain in Monkeypox Virus H3 as an Anti-poxviral Drug Target Combining AI and MD Simulations

    Bin Zheng, Meimei Duan ... Peng Zheng
    Revised
    Reviewed Preprint v2
    Updated
    1. Structural Biology and Molecular Biophysics
    2. Genetics and Genomics

    Tom1p ubiquitin ligase structure, interaction with Spt6p, and function in maintaining normal transcript levels and the stability of chromatin in promoters

    Jennifer Madrigal, Heidi L Schubert ... Christopher P Hill
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Ligand response of guanidine-IV riboswitch at single-molecule level

    Lingzhi Gao, Dian Chen, Yu Liu
    A folding-function model for the guanidine-IV riboswitch under both guanidine-free and guanidine-present conditions offers valuable insights into its regulatory mechanism.
    1. Structural Biology and Molecular Biophysics

    Atomic-Level Free Energy Landscape Reveals Cooperative Symport Mechanism of Melibiose Transporter

    Ruibin Liang, Lan Guan
    Not revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics

    Water and chloride as allosteric inhibitors in WNK kinase osmosensing

    Liliana R Teixeira, Radha Akella ... Elizabeth J Goldsmith
    WNKs sense osmotic pressure by binding specific water molecules to the inactive dimeric configuration of WNK1 and WNK3, integrating signals with chloride inhibition as demonstrated by mutagenesis and structure.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Mapping HIV-1 RNA Structure, Homodimers, Long-Range Interactions and persistent domains by HiCapR

    Yan Zhang, Jingwan Han ... Zhihu Zhao
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Recognition and Cleavage of Human tRNA Methyltransferase TRMT1 by the SARS-CoV-2 Main Protease

    Angel D’Oliviera, Xuhang Dai ... Jeffrey S Mugridge
    Revised
    Reviewed Preprint v2
    Updated
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Control of 3ʹ splice site selection by the yeast splicing factor Fyv6

    Katherine A Senn, Karli A Lipinski ... Aaron A Hoskins
    Revised
    Reviewed Preprint v2
    Updated
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Highlights

    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Modelling biomolecular condensates

    Furqan Dar, Rohit Pappu
    1. Structural Biology and Molecular Biophysics

    Same structure, different mechanisms?

    Francis TF Tsai, Christopher P Hill

Senior editors

  1. Felix Campelo
    The Institute of Photonic Sciences, Spain
  2. Volker Dötsch
    Goethe University, Germany
  3. Merritt Maduke
    Stanford University School of Medicine, United States
  4. See more editors