Structural Biology and Molecular Biophysics

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Structural Biology and Molecular Biophysics

   Surprising features of nuclear receptor interaction networks revealed by live-cell single-molecule imaging

   Liza Dahal, Thomas GW Graham ... Xavier Darzacq

   Type II nuclear receptors do not always compete for a limiting pool of their obligate partner RXRa.
2. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease

   Angel D'Oliviera, Xuhang Dai ... Jeffrey S Mugridge

   The SARS-CoV-2 main protease specifically cleaves a conserved sequence in the human tRNA modifying enzyme TRMT1, resulting in reduced tRNA binding and the complete loss of TRMT1-mediated tRNA methyltransferase activity.
3. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Opening and closing of a cryptic pocket in VP35 toggles it between two different RNA-binding modes

   Upasana L Mallimadugula, Matthew A Cruz ... Gregory R Bowman
4. 1. Developmental Biology
   2. Structural Biology and Molecular Biophysics

   The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

   Elise S Bruguera, Jacob P Mahoney, William I Weis

   Biophysical binding and structural prediction studies reveal that Tetraspanin12 directly binds the ligand Norrin, in a manner that is negatively cooperative with Norrin-Fzd4 binding and competitive with Norrin-LRP5/6 binding.
5. 1. Structural Biology and Molecular Biophysics

   The known unknowns of the Hsp90 chaperone

   Laura-Marie Silbermann, Benjamin Vermeer ... Katarzyna Tych

   An exploration of the unanswered questions in how the molecular chaperone Hsp90 supports protein homeostasis, and how single-molecule techniques could drive future breakthroughs in answering them.
6. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Electrostatics of Salt-Dependent Reentrant Phase Behaviors Highlights Diverse Roles of ATP in Biomolecular Condensates

   Yi-Hsuan Lin, Tae Hun Kim ... Hue Sun Chan
7. 1. Structural Biology and Molecular Biophysics

   N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine

   Chuchu Wang, Chunyu Zhao ... Cong Liu

   NMR and clustering results show that N-terminal acetylation of α-syn enhances its binding to the neutral phospholipid lysophosphatidylcholine, thereby promoting its function of clustering synaptic vesicles.
8. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia

   Raji E Joseph, Thomas E Wales ... Amy H Andreotti

   The clinically approved BTK kinase active site inhibitors alter the conformational equilibrium of full-length BTK in distinct and unexpected ways.
9. 1. Structural Biology and Molecular Biophysics

   Streamlining segmentation of cryo-electron tomography datasets with Ais

   Mart GF Last, Leoni Abendstein ... Thomas H Sharp

   The software package Ais simplifies automated segmentation in cryo-electron tomography, enabling users to segment, detect particles, and visualize data in a streamlined and accessible workflow.
10. 1. Structural Biology and Molecular Biophysics

    CTFFIND5 provides improved insight into quality, tilt, and thickness of TEM samples

    Johannes Elferich, Lingli Kong ... Nikolaus Grigorieff

    CTFFIND5 estimates the thickness and tilt of cryogenic electron microscopy samples directly from the power spectrum of a single exposure.