Structural Biology and Molecular Biophysics

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Opening and closing of a cryptic pocket in VP35 toggles it between two different RNA-binding modes

   Upasana L Mallimadugula, Matthew A Cruz ... Gregory R Bowman
2. 1. Developmental Biology
   2. Structural Biology and Molecular Biophysics

   The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

   Elise S Bruguera, Jacob P Mahoney, William I Weis

   Biophysical binding and structural prediction studies reveal that Tetraspanin12 directly binds the ligand Norrin, in a manner that is negatively cooperative with Norrin-Fzd4 binding and competitive with Norrin-LRP5/6 binding.
3. 1. Structural Biology and Molecular Biophysics

   The known unknowns of the Hsp90 chaperone

   Laura-Marie Silbermann, Benjamin Vermeer ... Katarzyna Tych

   An exploration of the unanswered questions in how the molecular chaperone Hsp90 supports protein homeostasis, and how single-molecule techniques could drive future breakthroughs in answering them.
4. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Electrostatics of Salt-Dependent Reentrant Phase Behaviors Highlights Diverse Roles of ATP in Biomolecular Condensates

   Yi-Hsuan Lin, Tae Hun Kim ... Hue Sun Chan
5. 1. Structural Biology and Molecular Biophysics

   N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine

   Chuchu Wang, Chunyu Zhao ... Cong Liu

   NMR and clustering results show that N-terminal acetylation of α-syn enhances its binding to the neutral phospholipid lysophosphatidylcholine, thereby promoting its function of clustering synaptic vesicles.
6. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia

   Raji E Joseph, Thomas E Wales ... Amy H Andreotti

   The clinically approved BTK kinase active site inhibitors alter the conformational equilibrium of full-length BTK in distinct and unexpected ways.
7. 1. Structural Biology and Molecular Biophysics

   CTFFIND5 provides improved insight into quality, tilt, and thickness of TEM samples

   Johannes Elferich, Lingli Kong ... Nikolaus Grigorieff

   CTFFIND5 estimates the thickness and tilt of cryogenic electron microscopy samples directly from the power spectrum of a single exposure.
8. 1. Structural Biology and Molecular Biophysics

   Streamlining segmentation of cryo-electron tomography datasets with Ais

   Mart GF Last, Leoni Abendstein ... Thomas H Sharp

   The software package Ais simplifies automated segmentation in cryo-electron tomography, enabling users to segment, detect particles, and visualize data in a streamlined and accessible workflow.
9. 1. Structural Biology and Molecular Biophysics

   Mechanism of expanded DNA recognition in xCas9

   Kazi A Hossain, Lukasz Nierzwicki ... Giulia Palermo
10. 1. Structural Biology and Molecular Biophysics

    Conformational dynamics of a nicotinic receptor neurotransmitter site

    Mrityunjay Singh, Dinesh C Indurthi ... Shailendra Asthana

    MD-simulations reveal low- to high-affinity conformational shift of orthosteric site in the nicotinic acetylcholine receptor, offering insight into agonist roles in activation dynamics, and highlighting the utility of agonist efficiency.