Structural Biology and Molecular Biophysics

Latest articles

1. 1. Structural Biology and Molecular Biophysics

   Binding to nucleosome poises SIRT6 for histone H3 de-acetylation

   Ekaterina Smirnova, Emmanuelle Bignon ... Adam Ben-Shem
2. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Drug Discovery: Decoding the mechanisms of allostery

   Saif Khan, Cornelius Gati

   A complex interplay between structure, conformational dynamics and pharmacology defines distant regulation of G protein-coupled receptors.
3. 1. Structural Biology and Molecular Biophysics

   Biological condensates form percolated networks with molecular motion properties distinctly different from dilute solutions

   Zeyu Shen, Bowen Jia ... Mingjie Zhang
4. 1. Neuroscience
   2. Structural Biology and Molecular Biophysics

   Coupling of Slack and Na_V1.6 sensitizes Slack to quinidine blockade and guides anti-seizure strategy development

   Tian Yuan, Yifan Wang ... Zhuo Huang
5. 1. Structural Biology and Molecular Biophysics

   Robust membrane protein tweezers reveal the folding speed limit of helical membrane proteins

   Seoyoon Kim, Daehyo Lee ... Duyoung Min
6. 1. Computational and Systems Biology
   2. Structural Biology and Molecular Biophysics

   Noncovalent antibody catenation on a target surface greatly increases the antigen-binding avidity

   Jinyeop Song, Bo-Seong Jeong ... Byung-Ha Oh

   Genetically fusing weakly homodimerizing proteins to the C-terminus of IgG antibodies to induce reversible catenation on a target surface greatly enhances antigen-binding avidity, offering a promising approach for a range of antibody applications.
7. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

   Ziva Vuckovic, Jinan Wang ... David M Thal

   Structural biology studies reveal the importance of protein dynamics on understanding molecular mechanisms underlying allosteric modulation of G protein-coupled receptors (GPCR) that offer insights into future GPCR research and drug discovery.
8. 1. Structural Biology and Molecular Biophysics

   The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate

   Raul Araya-Secchi, Katrine Bugge ... Birthe B Kragelund
9. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   The structural basis of the multi-step allosteric activation of Aurora B kinase

   Dario Segura-Peña, Oda Hovet ... Nikolina Sekulic
10. 1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of the connexin-43 gap junction channel in a putative closed state

    Chao Qi, Silvia Acosta-Gutierrez ... Volodymyr M. Korkhov