Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Structural Biology and Molecular Biophysics

    Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1

    Jing Xue, Weizhong Zeng ... Youxing Jiang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Structure, function and assembly of soybean primary cell wall cellulose synthases

    Ruoya Ho, Purushotham Pallinti ... Jochen Zimmer
    Structural and biochemical analyses suggest the association of homotrimeric CesAs of different isoforms into cellulose biosynthesis complexes via their class-specific regions.
    1. Structural Biology and Molecular Biophysics

    Multiphase separation in postsynaptic density regulated by membrane geometry via interaction valency and volume

    Risa Yamada, Giovanni B Brandani, Shoji Takada
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin

    Roman O Fedoryshchak, Karim El-Bouri ... Richard Treisman
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Domain Coupling in Allosteric Regulation of SthK Measured Using Time-Resolved Transition Metal Ion FRET

    Pierce Eggan, Sharona E Gordon, William N Zagotta
    Not revised
    Reviewed Preprint v1
    • Useful
    • Compelling
    1. Structural Biology and Molecular Biophysics

    AACDB: Antigen-Antibody Complex Database — a Comprehensive Database Unlocking Insights into Interaction Interface

    Yuwei Zhou, Wenwen Liu ... Jian Huang
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    A Kv2 inhibitor combination reveals native neuronal conductances consistent with Kv2/KvS heteromers

    Robert G Stewart, Matthew James Marquis ... Jon T Sack
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Shifting the PPARγ conformational ensemble towards a transcriptionally repressive state improves covalent inhibitor efficacy

    Liudmyla Arifova, Brian S MacTavish ... Douglas J Kojetin
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Protein Language Model Identifies Disordered, Conserved Motifs Driving Phase Separation

    Yumeng Zhang, Jared Zheng, Bin Zhang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Compelling
    1. Structural Biology and Molecular Biophysics

    ATP-release pannexin channels are gated by lysophospholipids

    Erik Henze, Russell N Burkhardt ... Toshimitsu Kawate
    Lysophospholipids directly and reversibly activate pannexin channels, triggering the release of signaling molecules critical for inflammation.
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Highlights

    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Modelling biomolecular condensates

    Furqan Dar, Rohit Pappu
    1. Structural Biology and Molecular Biophysics

    Same structure, different mechanisms?

    Francis TF Tsai, Christopher P Hill

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Felix Campelo
    The Institute of Photonic Sciences, Spain
  3. Kenton J Swartz
    National Institute of Neurological Disorders and Stroke, NIH, United States
  4. See more editors