Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Structural Biology and Molecular Biophysics

    Binding to nucleosome poises SIRT6 for histone H3 de-acetylation

    Ekaterina Smirnova, Emmanuelle Bignon ... Adam Ben-Shem
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Drug Discovery: Decoding the mechanisms of allostery

    Saif Khan, Cornelius Gati
    A complex interplay between structure, conformational dynamics and pharmacology defines distant regulation of G protein-coupled receptors.
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    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Noncovalent antibody catenation on a target surface greatly increases the antigen-binding avidity

    Jinyeop Song, Bo-Seong Jeong ... Byung-Ha Oh
    Genetically fusing weakly homodimerizing proteins to the C-terminus of IgG antibodies to induce reversible catenation on a target surface greatly enhances antigen-binding avidity, offering a promising approach for a range of antibody applications.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

    Ziva Vuckovic, Jinan Wang ... David M Thal
    Structural biology studies reveal the importance of protein dynamics on understanding molecular mechanisms underlying allosteric modulation of G protein-coupled receptors (GPCR) that offer insights into future GPCR research and drug discovery.

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Nancy Carrasco
    Vanderbilt University School of Medicine, United States
  3. Volker Dötsch
    Goethe University, Germany
  4. See more editors