Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife publishes research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality

    Mohamed A Badawy et al.
    Electron paramagnetic resonance spectroscopy quantitatively correlates structural damages of serum albumin with COVID-19 severity and mortality thus suggesting albumin replacement therapy as a strategy to rescue patients at risk of mortality.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation

    Jesse M Hansen et al.
    The yeast enzyme CTP synthase assembles inactive filaments that are driven to polymerization through the drop in cytoplasmic pH accompanying starvation.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Markov state models of proton- and pore-dependent activation in a pentameric ligand-gated ion channel

    Cathrine Bergh et al.
    Computational models of gating processes in an ion channel show how stability shifts upon ligand-binding and mutations are reproduced, which highlights mechanistic details and proposes a new role for symmetry in gating.
    1. Structural Biology and Molecular Biophysics

    Tracking the movement of discrete gating charges in a voltage-gated potassium channel

    Michael F Priest et al.
    Experimental measurement of the trajectory of gating charge surrogates during voltage activation and deactivation in a voltage sensor.
    1. Structural Biology and Molecular Biophysics

    Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates

    Shan Zhou et al.
    The three-dimensional structures of Mycobacterium tuberculosis cytochrome bcc in complex with the antituberculosis agents, Q203 and TB47, explain how these inhibitors suppress activity of the complex.

Senior editors

  1. Richard Aldrich
    Richard Aldrich
    The University of Texas at Austin, United States
  2. Nancy Carrasco
    Vanderbilt University School of Medicine, United States
  3. Cynthia Wolberger
    Johns Hopkins University School of Medicine, United States
  4. See more editors