Structural Biology and Molecular Biophysics

Latest articles

1. 1. Structural Biology and Molecular Biophysics

   PROTAC-induced Protein Functional Dynamics in Targeted Protein Degradation

   Kingsley Y Wu, Ta I Hung, Chia-en A Chang
2. 1. Structural Biology and Molecular Biophysics

   Empowering AlphaFold2 for protein conformation selective drug discovery with AlphaFold2-RAVE

   Xinyu Gu, Akashnathan Aranganathan, Pratyush Tiwary

   AlphaFold2's inability to generate non-native conformations for docking is addressed by AI-molecular dynamics method AlphaFold2-RAVE, which produces Boltzmann-ranked conformations, enabling the retrospective discovery of type II kinase inhibitors.
3. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Electrostatics of Salt-Dependent Reentrant Phase Behaviors Highlights Diverse Roles of ATP in Biomolecular Condensates

   Yi-Hsuan Lin, Tae Hun Kim ... Hue Sun Chan
4. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Control of 3’ splice site selection by the yeast splicing factor Fyv6

   Katherine A Senn, Karli A Lipinski ... Aaron A Hoskins
5. 1. Structural Biology and Molecular Biophysics
   2. Plant Biology

   Structure of the Calvin-Benson-Bassham sedoheptulose-1,7-bisphosphatase from the model microalga Chlamydomonas reinhardtii

   Théo Le Moigne, Martina Santoni ... Julien Henri
6. 1. Structural Biology and Molecular Biophysics

   Dynamic basis of lipopolysaccharide export by LptB₂FGC

   Marina Dajka, Tobias Rath ... Benesh Joseph
7. 1. Structural Biology and Molecular Biophysics

   A cryo-ET study of ciliary rootlet organization

   Chris van Hoorn, Andrew P Carter
8. 1. Structural Biology and Molecular Biophysics

   Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans

   Dipti Ranjan Lenka, Shakti Virendra Dahe ... Atul Kumar

   The new insights into the activation mechanism of Parkin E3 ligase could be useful for designing small-molecule activators against Parkinson’s disease.
9. 1. Structural Biology and Molecular Biophysics

   Structure and dynamics of cholesterol-mediated aquaporin-0 arrays and implications for lipid rafts

   Po-Lin Chiu, Juan D Orjuela ... Thomas Walz

   Electron crystallography and molecular dynamics simulations show that a cholesterol sandwiched in between two neighboring aquaporin-0 tetramers stabilizes the association between the tetramers and thus promotes array formation.
10. 1. Structural Biology and Molecular Biophysics

    The Arthropoda-specific Tramtrack group BTB protein domains use previously unknown interface to form hexamers

    Artem N Bonchuk, Konstantin I Balagurov ... Pavel G Georgiev