Structural Biology and Molecular Biophysics

Latest articles

1. 1. Structural Biology and Molecular Biophysics

   Optimising the tilt increment for in situ cryo-electron tomography

   Maarten Willem Tuijtel, Tomáš Majtner ... Martin Beck

   For in situ cryo-electron tomography, smaller tilt increments yield better-aligned tilt-series and higher-quality tomograms, with a 3° increment resulting in optimal subtomogram averaging resolution.
2. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation

   Isaac J Fisher, Kanishka Senarath ... Angeline M Lyon
3. 1. Physiology
   2. Structural Biology and Molecular Biophysics

   Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy

   Giulia Arecchi, Marica Dente ... Chiara Tesi

   Label-free optical imaging provides a direct readout of relaxed myosin conformational states in skeletal and cardiac muscle.
4. 1. Structural Biology and Molecular Biophysics

   Cryo-EM structure of the bicarbonate receptor GPR30

   Shota Kaneda, Airi Jo-Watanabe ... Osamu Nureki

   Cryo-electron microscopy structure of human G-protein-coupled receptor 30 in the presence of bicarbonate ions revealed unique extracellular pockets and critical residues for bicarbonate binding and activation.
5. 1. Structural Biology and Molecular Biophysics
   2. Cell Biology

   A biochemical mechanism for Stu2/XMAP215-family microtubule polymerases

   Binnu Gangadharan, Daniel L Kober, Luke M Rice
6. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Investigation of Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis

   Marie Shimogawa, Ming-Hao Li ... E James Petersson
7. 1. Structural Biology and Molecular Biophysics

   Molecular basis of mitogen-activated protein kinase ERK2 activation by its upstream kinase MEK1

   Jill von Velsen, Pauline Juyoux ... Matthew W Bowler
8. 1. Structural Biology and Molecular Biophysics

   Characterization of an early-diverging KCNE potassium-channel auxiliary subunit in the jawless vertebrate lamprey

   Go Kasuya, Kaei Ryu ... Koichi Nakajo
9. 1. Structural Biology and Molecular Biophysics

   A membrane insertion code for intrinsically disordered proteins

   Fidha Nazreen Kunnath Muhammedkutty, Huan-Xiang Zhou
10. 1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    ATP-driven conformational dynamics reveal hidden intermediates in a heterodimeric ABC transporter

    Matija Pečak, Christoph Nocker, Robert Tampé

    Hidden outward-facing intermediates and long-lived ATP-bound states reveal how ATP binding drives conformational dynamics in the heterodimeric ABC transporter TmrAB.