Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife publishes research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Evolutionary Biology
    2. Structural Biology and Molecular Biophysics

    Structurally distributed surface sites tune allosteric regulation

    James W McCormick et al.
    Deep mutational scanning of a synthetic allosteric chimera revealed that a sparse set of mutations on the protein surface improved regulation.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Analysis of the PcrA-RNA polymerase complex reveals a helicase interaction motif and a role for PcrA/UvrD helicase in the suppression of R-loops

    Inigo Urrutia-Irazabal et al.
    RNA polymerase recruits the PcrA DNA helicase via a conserved interaction motif in order to remove R-loops and prevent conflicts with replication.
    1. Structural Biology and Molecular Biophysics

    Structure and analysis of nanobody binding to the human ASIC1a ion channel

    Yangyu Wu et al.
    Development of specific and high-affinity nanobodies to probe the structure of human acid sensing ion channel-1a and as binding modifiers of the toxins PcTx and MitTx1.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Calponin-homology domain mediated bending of membrane-associated actin filaments

    Saravanan Palani et al.
    Combination of actin and curly on lipid membranes constitutes a new, minimalistic system to generate high curvature actin rings that can contract upon the action of myosin II filaments.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The fluoride permeation pathway and anion recognition in Fluc family fluoride channels

    Benjamin C McIlwain et al.
    In the extremely selective fluoride channels from the bacterial Fluc family, fluoride ions access the pore via two points, an electropositive vestibule and a triad of conserved residues involved in anion recognition.
    1. Structural Biology and Molecular Biophysics

    Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

    Fenghui Zhao et al.
    The structure provides key insights into hormone recognition and activation of the glucose-dependent insulinotropic polypeptide receptor.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures of the caspase-activated protein XKR9 involved in apoptotic lipid scrambling

    Monique S Straub et al.
    The cryo-EM structures of XKR9 define the architecture and caspase-mediated activation of a protein family that is involved in the exposure of phosphatidylserine during apoptosis leading to the engulfment of apoptotic cells by macrophages.

Senior editors

  1. Richard Aldrich
    Richard Aldrich
    The University of Texas at Austin, United States
  2. Olga Boudker
    Weill Cornell Medicine, United States
  3. Philip Cole
    Harvard Medical School, United States
  4. See more editors