Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Structural Biology and Molecular Biophysics

    Insights into substrate binding and utilization by hyaluronan synthase

    Zachery Stephens, Julia Karasinska, Jochen Zimmer
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Protein-induced membrane strain drives supercomplex formation

    Maximilian C Pöverlein, Alexander Jussupow ... Ville RI Kaila
    Respiratory supercomplex formation relieves molecular strain of mitochondrial membranes and reshapes global protein motions, linking membrane reorganization to respiratory function.
    1. Structural Biology and Molecular Biophysics

    Structure of the human CTF18−RFC clamp loader bound to PCNA

    Giuseppina R Briola, Mohammad Tehseen ... Alfredo De Biasio
    Human CTF18–RFC employs a unique structural stabilization mechanism to optimize PCNA loading and stimulate DNA synthesis by the leading-strand polymerase.
    1. Structural Biology and Molecular Biophysics

    Multi-barrier unfolding of the double-knotted protein, TrmD–Tm1570, revealed by single-molecule force spectroscopy and molecular dynamics

    Fernando Bruno da Silva, Szymon Niewieczerzal ... Joanna I Sulkowska
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics

    A novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolution

    Saulė Špokaitė, Yohei Ohashi ... Roger L Williams
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Bifunctional Architecture Enables Substrate Catalysis and Channeling in Paracoccus TMAO Demethylase

    Trung Thach, KanagaVijayan Dhanabalan ... Ramaswamy Subramanian
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    A Structural Code for Assembly Specificity in GID/CTLH-Type E3 Ligases

    Pia Maria van gen Hassend, Hermann Schindelin
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Pulsed laser lensing for phase modulation in electron microscopy

    Daniel X Du, Adam C Bartnik ... Anthony WP Fitzpatrick
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Unraveling the Molecular Mechanisms of ABHD5 Membrane Targeting

    Amit Kumar, Matthew Sanders ... Yu-ming M Huang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Multiple modes of cholesterol translocation in the human Smoothened receptor

    Prateek Bansal, Maia Kinnebrew ... Diwakar Shukla
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    • Solid
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Highlights

    1. Structural Biology and Molecular Biophysics

    Lipids, ligands and receptor proteins

    Adam JM Wollman
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Modelling biomolecular condensates

    Furqan Dar, Rohit Pappu

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Felix Campelo
    Pompeu Fabra University, Spain
  3. Volker Dötsch
    Goethe University, Germany
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