Structural Biology and Molecular Biophysics

Latest articles

1. 1. Structural Biology and Molecular Biophysics

   Ion permeation pathway within the internal pore of P2X receptor channels

   Stephanie W Tam, Kate Huffer ... Kenton J Swartz

   Mapping the ion permeation pathway within the internal pore of ATP-activated P2X receptor channels.
2. 1. Structural Biology and Molecular Biophysics

   Peptides that Mimic RS repeats modulate phase separation of SRSF1, revealing a reliance on combined stacking and electrostatic interactions

   Talia Fargason, Naiduwadura Ivon Upekala De Silva ... Jun Zhang

   Short peptides that mimic the regions responsible for phase separation can be used to solubilize phase-separating proteins in their native states and to determine the mechanism of phase separation.
3. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk with altered NTD dynamics

   Sean M Braet, Theresa SC Buckley ... Ganesh Srinivasan Anand
4. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Concurrent remodeling of nucleolar 60S subunit precursors by the Rea1 ATPase and Spb4 RNA helicase

   Valentin Mitterer, Matthias Thoms ... Roland Beckmann
5. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities

   Giuseppina Mastrototaro, Pierluigi Carullo ... Marie-Louise Bang
6. 1. Structural Biology and Molecular Biophysics

   Conserved allosteric inhibition mechanism in SLC1 transporters

   Yang Dong, Jiali Wang ... Christof Grewer

   Functional and computational studies reveal that the allosteric inhibition mechanism is conserved between glutamate and neutral amino acid transporters of the SLC1 family, and identify a novel allosteric inhibitor.
7. 1. Cell Biology
   2. Structural Biology and Molecular Biophysics

   Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel

   Peter R Strege, Luke M Cowan ... Arthur Beyder
8. 1. Structural Biology and Molecular Biophysics

   Structural basis for the Rad6 activation by the Bre1 N-terminal domain

   Meng Shi, Jiaqi Zhao ... Song Xiang
9. 1. Structural Biology and Molecular Biophysics

   Cryo-EM structures of a LRRC8 chimera with native functional properties reveal heptameric assembly

   Hirohide Takahashi, Toshiki Yamada ... Erkan Karakas
10. 1. Structural Biology and Molecular Biophysics

    Conformational and oligomeric states of SPOP from small-angle X-ray scattering and molecular dynamics simulations

    F Emil Thomasen, Matthew J Cuneo ... Kresten Lindorff-Larsen

    Self-association of speckle-type POZ protein (SPOP), a substrate adaptor in the ubiquitin proteasome system, is studied by combining small-angle X-ray scattering and molecular dynamics simulations to reveal the structure of the protein assemblies in solution.