Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Structural Biology and Molecular Biophysics

    PUFA stabilizes a conductive state of the selectivity filter in IKs channels

    Alessia Golluscio, Jodene Eldstrom ... H. Peter Larsson
    1. Structural Biology and Molecular Biophysics

    Martinize2 and Vermouth: Unified Framework for Topology Generation

    PC Kroon, F Grunewald ... SJ Marrink
    1. Structural Biology and Molecular Biophysics

    Role of N343 glycosylation on the SARS-CoV-2 S RBD structure and co-receptor binding across variants of concern

    Callum M Ives, Linh Nguyen ... Elisa Fadda
    Viral evolution can lead to mutations that render specific glycosylation sites dispensable for folding and for supporting the protein's function, allowing changes in the shield, and in the immunogenic profile.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Rapid, DNA-induced interface swapping by DNA gyrase

    Thomas RM Germe, Natassja G Bush ... Anthony Maxwell
    DNA gyrase, a regulator of bacterial genomes topology, is shown to undergo rearrangements while functioning on DNA in vitro, with important potential consequences for gyrase-targeted antibiotics activity and bacterial evolution.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase

    Marian Brenner, Christoph Zink ... Antje Gohla
    Direct inhibition of pyridoxal phosphatase activity by 7,8-dihydroxyflavone indicates a pharmacological entry point into brain disorders associated with vitamin B6 deficiency.
    1. Structural Biology and Molecular Biophysics

    Wide Transition-State Ensemble as Key Component for Enzyme Catalysis

    Gabriel Ernesto Jara, Francesco Pontiggia ... Dorothee Kern
    1. Structural Biology and Molecular Biophysics

    A cryo-ET study of ciliary rootlet organization

    Chris van Hoorn, Andrew P. Carter

Senior editors

  1. Felix Campelo
    The Institute of Photonic Sciences, Spain
  2. Volker Dötsch
    Goethe University, Germany
  3. Merritt Maduke
    Stanford University School of Medicine, United States
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