Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The catalytic mechanism of the RNA methyltransferase METTL3

    Ivan Corbeski, Pablo Andrés Vargas-Rosales ... Amedeo Caflisch
    1. Structural Biology and Molecular Biophysics

    Mobile barrier mechanisms for Na+-coupled symport in an MFS sugar transporter

    Parameswaran Hariharan, Yuqi Shi ... Lan Guan
    The use of a conformation-selective inhibitory nanobody provides critical information on MelB at a low-sugar affinity inward-facing Na+-bound state for establishing the mobile barrier and substrate-releasing mechanisms.
    1. Structural Biology and Molecular Biophysics

    Disordered regions and folded modules in CAF-1 promote histone deposition in Schizosaccharomyces pombe

    Fouad Ouasti, Maxime Audin ... Francoise Ochsenbein
    Histone, PCNA, and DNA binding are essential for CAF-1 functions in preventing DNA damage during DNA replication in Schizosaccharomyces pombe, while its C-terminal domain specifies distinct cellular processes.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Nucleosome conformation dictates the histone code

    Matthew R Marunde, Harrison A Fuchs ... Catherine A Musselman
    NMR spectroscopy, dCypher assays, and CUT&RUN demonstrate that occlusion of the histone tails in the nucleosome context alters histone PTM specificity for a tandem of reader domains.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Asymmetric framework motion of TCRαβ controls load-dependent peptide discrimination

    Ana C Chang-Gonzalez, Robert J Mallis ... Wonmuk Hwang
    All-atom molecular dynamics simulations of an αβ T-cell receptor complexed with the major histocompatibility complex molecule presenting wild-type or mutant antigenic peptides reveal how it uses conserved framework motion to discriminate antigens by leveraging physiological force applied during immune surveillance.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mapping the architecture of the initiating phosphoglycosyl transferase from S. enterica O-antigen biosynthesis in a liponanoparticle

    Greg J Dodge, Alyssa J Anderson ... Barbara Imperiali
    Structural, functional, and bioinformatics analyses further understanding of the initial steps of prokaryotic glycoconjugate biosynthesis catalyzed by the large class of membrane-embedded monotopic phosphoglycosyl transferase superfamily.

Senior editors

  1. Felix Campelo
    The Institute of Photonic Sciences, Spain
  2. Qiang Cui
    Boston University, United States
  3. Volker Dötsch
    Goethe University, Germany
  4. See more editors