Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife publishes research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we publish and sign up for the latest research.
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Latest articles

    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The KASH5 protein involved in meiotic chromosomal movements is a novel dynein activating adaptor

    Ritvija Agrawal et al.
    KASH5 uses an EF-hand domain to directly interact with the light intermediate chain of dynein, promotes processive dynein motility, and facilitates dynein recruitment to the nuclear envelope during prophase I of meiosis.
    1. Structural Biology and Molecular Biophysics

    Tonic inhibition of the chloride/proton antiporter ClC-7 by PI(3,5)P2 is crucial for lysosomal pH maintenance

    Xavier Leray et al.
    Inhibiyiton of the lysosomal chloride-proton antiporter ClC-7 by the signaling lipid PI(3,5)P2 is important for lysosomal pH maintenance and is disrupted by a disease-causing gain-of-function mutation.
    1. Structural Biology and Molecular Biophysics

    All-atom molecular dynamics simulations of Synaptotagmin-SNARE-complexin complexes bridging a vesicle and a flat lipid bilayer

    Josep Rizo et al.
    Novel insights into the molecular mechanisms underlying neurotransmitter release are provided by all-atom molecular dynamics simulations including SNARE proteins, synaptotagmin-1, complexin-1, a vesicle and a flat bilayer.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    CAMSAP2 organizes a γ-tubulin-independent microtubule nucleation centre through phase separation

    Tsuyoshi Imasaki et al.
    CAMSAP2 co-condensates with αβ-tubulin to induce microtubule nucleation and growth, serving as a microtubule-organizing centre for non-centrosomal microtubules.
    1. Structural Biology and Molecular Biophysics

    Filamentation modulates allosteric regulation of PRPS

    Huan-Huan Hu et al.
    Cryo-EM structures of two types of prokaryotic Phosphoribosyl pyrophosphate synthase filaments reveal that filamentation into cytoophidia provides a new layer of metabolic regulation.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers

    Vladislav Belyy et al.
    Stress sensors in the membrane of the endoplasmic reticulum respond to the accumulation of unfolded proteins by briefly forming small phosphorylation-competent oligomers and dissolving back into active dimers.

Senior editors

  1. Richard Aldrich
    Richard Aldrich
    The University of Texas at Austin, United States
  2. Nancy Carrasco
    Vanderbilt University School of Medicine, United States
  3. Kenton J Swartz
    National Institute of Neurological Disorders and Stroke, NIH, United States
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