Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Structural Biology and Molecular Biophysics

    Ion permeation pathway within the internal pore of P2X receptor channels

    Stephanie W Tam, Kate Huffer ... Kenton J Swartz
    Mapping the ion permeation pathway within the internal pore of ATP-activated P2X receptor channels.
    1. Structural Biology and Molecular Biophysics

    Peptides that Mimic RS repeats modulate phase separation of SRSF1, revealing a reliance on combined stacking and electrostatic interactions

    Talia Fargason, Naiduwadura Ivon Upekala De Silva ... Jun Zhang
    Short peptides that mimic the regions responsible for phase separation can be used to solubilize phase-separating proteins in their native states and to determine the mechanism of phase separation.
    1. Structural Biology and Molecular Biophysics

    Conserved allosteric inhibition mechanism in SLC1 transporters

    Yang Dong, Jiali Wang ... Christof Grewer
    Functional and computational studies reveal that the allosteric inhibition mechanism is conserved between glutamate and neutral amino acid transporters of the SLC1 family, and identify a novel allosteric inhibitor.
    1. Structural Biology and Molecular Biophysics

    Conformational and oligomeric states of SPOP from small-angle X-ray scattering and molecular dynamics simulations

    F Emil Thomasen, Matthew J Cuneo ... Kresten Lindorff-Larsen
    Self-association of speckle-type POZ protein (SPOP), a substrate adaptor in the ubiquitin proteasome system, is studied by combining small-angle X-ray scattering and molecular dynamics simulations to reveal the structure of the protein assemblies in solution.

Senior editors

  1. Richard Aldrich
    Richard Aldrich
    The University of Texas at Austin, United States
  2. Nancy Carrasco
    Vanderbilt University School of Medicine, United States
  3. Volker Dötsch
    Goethe University, Germany
  4. See more editors