Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife publishes research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    SSNA1 stabilizes dynamic microtubules and detects microtubule damage

    Elizabeth J Lawrence et al.
    SSNA1 is a potent microtubule stabilizer and novel sensor of microtubule damage, acting on both microtubule ends and lattices to regulate microtubule dynamics and protect microtubules against severing activity.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites

    Noah M Dietzen et al.
    Docosahexaenoic acid (DHA) inhibits ELIC through state-dependent binding to a single site.
    1. Structural Biology and Molecular Biophysics

    Nanofluidic chips for cryo-EM structure determination from picoliter sample volumes

    Stefan T Huber et al.
    A novel strategy for reproducible cryo-EM sample preparation with minimal sample volumes.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Molecular structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography

    Johannes Elferich et al.
    Direct imaging of individual molecules of the tip-link protein PCDH15 in mouse stereocilia shows that it assembles as a dimer, forms complexes that span stereocilia, and occurs in clusters with multiple copies of the PCDH15 dimer.
    1. Structural Biology and Molecular Biophysics

    A modular platform for automated cryo-FIB workflows

    Sven Klumpe et al.
    SerialFIB is an adaptable open-source software designed for streamlining, advanced development and automation of cryo-focused ion beam-based cellular preparations for in situ cryo-electron tomography.

Senior editors

  1. Richard Aldrich
    Richard Aldrich
    The University of Texas at Austin, United States
  2. Volker Dötsch
    Goethe University, Germany
  3. Kenton J Swartz
    National Institute of Neurological Disorders and Stroke, NIH, United States
  4. See more editors