Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Structural Biology and Molecular Biophysics

    Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses

    Aya Matsui, Cathy Spangler ... Eric Gouaux
    By harnessing antibody fragments conjugated to small gold nanoparticles together with high pressure freezing, FIB/SEM milling and cryo-electron tomography, AMPA receptors were identified from mouse brain tissue.
    1. Structural Biology and Molecular Biophysics

    TMEM16 and OSCA/TMEM63 proteins share a conserved potential to permeate ions and phospholipids

    Augustus J Lowry, Pengfei Liang ... Yang Zhang
    Proteins in the Transmembrane Channel-Scramblase (TCS) superfamily share an evolutionarily conserved ability to permeate ions and phospholipids, challenging distinctions between ion channels and lipid scramblases.
    1. Structural Biology and Molecular Biophysics

    Conservation of the cooling agent binding pocket within the TRPM subfamily

    Kate Huffer, Matthew CS Denley ... Kenton J Swartz
    The cooling agent pocket in TRPM8 is conserved in a subset of other TRPM channels and the cooling agent icilin can regulate opening of TRPM4 channels in response to calcium and voltage.
    1. Structural Biology and Molecular Biophysics

    PUFA stabilizes a conductive state of the selectivity filter in IKs channels

    Alessia Golluscio, Jodene Eldstrom ... H Peter Larsson
    Polyunsaturated fatty acids activate IKs channels by stabilizing a conductive state of the selectivity filter.
    1. Structural Biology and Molecular Biophysics

    Predicting the sequence-dependent backbone dynamics of intrinsically disordered proteins

    Sanbo Qin, Huan-Xiang Zhou
    SeqDYN, a sequence-based method, accurately predicts the residue-specific transverse relaxation rates of intrinsically disordered proteins.
    1. Structural Biology and Molecular Biophysics

    Elucidating ATP’s role as solubilizer of biomolecular aggregate

    Susmita Sarkar, Saurabh Gupta ... Jagannath Mondal
    ATP prevents condensation of aggregation-prone intrinsically disordered protein by modulating its conformation.
    1. Structural Biology and Molecular Biophysics

    Direct and Indirect Salt Effects on Homotypic Phase Separation

    Matthew MacAinsh, Souvik Dey, Huan-Xiang Zhou
    Revised
    Reviewed Preprint v2 Updated
    1. Structural Biology and Molecular Biophysics

    Protein-Induced Membrane Strain Drives Supercomplex Formation

    Maximilian C Pöverlein, Alexander Jussupow ... Ville RI Kaila
    Not yet revised
    Reviewed Preprint v1

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Qiang Cui
    Boston University, United States
  3. Volker Dötsch
    Goethe University, Germany
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