Structural Biology and Molecular Biophysics

Latest articles

1. 1. Structural Biology and Molecular Biophysics

   In extracto cryo-EM reveals eEF2 as a major hibernation factor on 60S and 80S particles

   Zahra Seraj, Ximena Zottig ... Andrei A Korostelev
2. 1. Structural Biology and Molecular Biophysics

   In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies

   Yanqing Yang, Lulu Qiao ... Ruhong Zhou
3. 1. Structural Biology and Molecular Biophysics

   Conformational Changes of the ABC Transporter BmrA Depend on Membrane Curvature

   Alicia Damm, Kemil Belhadji ... Patricia Bassereau
4. 1. Structural Biology and Molecular Biophysics

   Allosteric effects of the coupling cation in melibiose transporter MelB

   Parameswaran Hariharan, Yuqi Shi ... Lan Guan

   Intrinsic conformational flexibility of a solute transporter is restrained by substrates, resulting in Na+ allosterically enhancing primary substrate binding through cooperative constraints on the dynamics of the cytoplasmic inner barrier.
5. 1. Structural Biology and Molecular Biophysics

   Cryo-EM structure revealed a novel F-actin binding motif in a Legionella pneumophila lysine fatty acyltransferase

   Wenjie W Zeng, Garrison Komaniecki ... Yuxin Mao

   A novel F-actin-binding motif consisting of an α-helix hairpin from a Legionella pneumophila lysine fatty acyltransferase has the potential to be developed as an F-actin probe.
6. 1. Structural Biology and Molecular Biophysics

   Structure of the human CTF18–RFC clamp loader bound to PCNA

   Giuseppina R Briola, Muhammad Tehseen ... Alfredo De Biasio
7. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Shifting the PPARγ conformational ensemble toward a transcriptionally repressive state improves covalent inhibitor efficacy

   Liudmyla Arifova, Brian S MacTavish ... Douglas J Kojetin

   Covalent PPARγ inhibitors that better stabilize a repressive conformation are more effective inhibitors, but structural plasticity still allows ligand cobinding by enabling a shift back to an active conformation.
8. 1. Structural Biology and Molecular Biophysics

   Ω-Loop mutations control dynamics of the active site by modulating the hydrogen-bonding network in PDC-3 β-lactamase

   Shuang Chen, Andrew R Mack ... Shozeb Haider

   Clinically relevant Ω-loop mutations in PDC-3 reshape active-site dynamics to enhance β-lactamase activity, providing mechanistic insights that can guide the rational design of inhibitors.
9. 1. Structural Biology and Molecular Biophysics

   Active regulation of the epidermal growth factor receptor by the membrane bilayer

   Shwetha Srinivasan, Xingcheng Lin ... Gabriela S Schlau-Cohen
10. 1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Effects of residue substitutions on the cellular abundance of proteins

    Thea K Schulze, Kresten Lindorff-Larsen