Correction: Replication Study: BET bromodomain inhibition as a therapeutic strategy to target c-Myc

Aird F, Kandela I, Mantis C, Reproducibility Project: Cancer Biology. 2017. Replication Study: BET bromodomain inhibition as a therapeutic strategy to target c-Myc. eLife 6:e21253. doi: 10.7554/eLife.21253.

Published 19, January 2017

This is a corrigendum for Replication Study: BET bromodomain inhibition as a therapeutic strategy to target c-Myc.

The calculation of variance in the meta-analysis of the overall survival distributions for mice treated with (+)-JQ1 vs. mice treated with vehicle control (Figure 4B) is incorrect. Subsequently, the effect size and the associated p value of the meta-analysis are incorrect. The effect size (Hazard Ratio) for this comparison should be HR = 9.16 95% CI [1.39, 60.54] (instead of the reported HR = 13.12 95% CI [1.79, 96.02]) resulting in a p value of p = 0.0215 (instead of the reported p = 0.0112).

The language surrounding this comparison in the Results and Discussion section as well as in Figure 4 and the Figure Legend (Figure 4B) have been amended to account for this correction. Additional r code for the meta-analysis can be found on the Open Science Framework: https://osf.io/x6g87/.

The corrected Figure 4 is shown here:

The originally published Figure 4 is also shown for reference:

The article has now been corrected.