Advances in Cancer Research: Authors share their research on World Cancer Day

eLife authors discuss their latest findings in brain tumours, breast, muscle and pancreatic cancer.
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This World Cancer Day, five authors have introduced their research and shared their recent findings in short videos for eLife. From Brain tumours, to breast and pancreatic cancer, hear about the latest advances in the field of cancer research.

You can watch each of the recordings below. We also encourage you to annotate with any questions and comments for the authors.

Dirk Sieger, Uniersity of Edinburgh

Sieger discusses his latest research, intended to improve our understanding of how tumor cells and immune cells interact in the brain. In order to mimic human brain tumors, he and his colleagues expressed a cancer-promoting version of a human protein in nerve cells of zebrafish larvae. Read more in their eLife study, ‘Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain’, funded by Cancer Research UK.

Giulia Bertolin, Centre national de la recherche scientifique (CNRS)

Bertolin shares the latest insights into whether mitochondria cells use AURKA proteins to communicate inside human breast cancer cells, as examined in her Research Article, ‘Aurora kinase A localises to mitochondria to control organelle dynamics and energy production’.

Ethan Abel, University of Michigan

Abel shines a light on his work looking for proteins that are more abundant in human pancreatic cancer stem cells than in other, less aggressive cancer cells. His team’s work into the protein HNF1A, which was found to be enriched in pancreatic cancer stem cells, is detailed in their Research Article, ‘HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties’.

Geoffrey Greene and Sean Fanning, University of Chicago

Greene and Fanning report that a well-known drug can target estrogen receptors which have become resistant to treatment, as shared in the recent eLife paper, ‘The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells’.

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