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This World Cancer Day, five authors have introduced their research and shared their recent findings in short videos for eLife. From Brain tumours, to breast and pancreatic cancer, hear about the latest advances in the field of cancer research.
You can watch each of the recordings below. We also encourage you to annotate with any questions and comments for the authors.
Sieger discusses his latest research, intended to improve our understanding of how tumor cells and immune cells interact in the brain. In order to mimic human brain tumors, he and his colleagues expressed a cancer-promoting version of a human protein in nerve cells of zebrafish larvae. Read more in their eLife study, ‘Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain’, funded by Cancer Research UK.
Bertolin shares the latest insights into whether mitochondria cells use AURKA proteins to communicate inside human breast cancer cells, as examined in her Research Article, ‘Aurora kinase A localises to mitochondria to control organelle dynamics and energy production’.
Abel shines a light on his work looking for proteins that are more abundant in human pancreatic cancer stem cells than in other, less aggressive cancer cells. His team’s work into the protein HNF1A, which was found to be enriched in pancreatic cancer stem cells, is detailed in their Research Article, ‘HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties’.
Greene and Fanning report that a well-known drug can target estrogen receptors which have become resistant to treatment, as shared in the recent eLife paper, ‘The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells’.