Response to comment on 'Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age'
- Calico Life Sciences, LLC, United States
Figures
Figure 1
Exclusion of all pre-2008 lifespan data through left-censorship did not modify the observed lifespan demographics of H. glaber.
(A) Kaplan–Meier survival curve for naked mole-rats after reaching reproductive maturity (Tsex; 6 months from birth; 183 days; red). Green: original calculation (Figure 1 of Ruby et al., 2018). Orange: calculation on the same data, left-truncated on January 1, 2008 (see Materials and methods). Purple: expected survivals from Tsex given a constant mortality hazard of 8 × 10−5 per day (Ruby et al., 2018). Inset: a histogram of left-censorship events. (B) Hazard estimates across each of the lifespan bins (from Figure 1B of Ruby et al., 2018), calculated for both of the survival plots from panel (A), colored as in panel (A). Vertical bars indicate 95% confidence intervals. Dotted grey line indicates 8 × 10−5 deaths per day.
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Response to comment on 'Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age'
eLife 8:e47047.
https://doi.org/10.7554/eLife.47047
