Response to comment on ‘SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung’

  1. Alan E Mast
  2. Alisa S Wolberg
  3. David Gailani
  4. Michael R Garvin
  5. Christiane Alvarez
  6. J Izaak Miller
  7. Piet Jones
  8. Bruce Aronow
  9. Daniel Jacobson  Is a corresponding author
  1. Versiti Blood Research Institute, Department of Cell Biology Neurobiology and Anatomy Medical College of Wisconsin, United States
  2. Department of Pathology and Laboratory Medicine and UNC Blood Research Center, United States
  3. Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, United States
  4. Oak Ridge National Laboratory, Biosciences Division, United States
  5. University of Tennessee Knoxville, The Bredesen Center for Interdisciplinary Research and Graduate Education, United States
  6. Biomedical Informatics, Cincinnati Children’s Hospital Research Foundation, University of Cincinnati, United States
2 figures

Figures

Correlation between log-fold change with rRNA and the adjusted log-fold change without rRNA (R2 ~0.99954).
Read mappings to the transcript NM_001993 for the F3 mRNA taken from one of the controls (top) and a case (bottom) used in Mast et al.

Mapping settings were set to mismatch cost = 2, insertion cost = 3, deletion cost = 3, length fraction = 0.95, similarity fraction = 0.95. The Alu element in the 3’UTR (brick), promoter (green), and coding sequence (dark yellow) of the transcript are annotated. Blue read mappings are paired reads that mapped a single time and light yellow are read mappings that aligned to multiple places in the transcriptome (i.e. other genes besides F3).

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  1. Alan E Mast
  2. Alisa S Wolberg
  3. David Gailani
  4. Michael R Garvin
  5. Christiane Alvarez
  6. J Izaak Miller
  7. Piet Jones
  8. Bruce Aronow
  9. Daniel Jacobson
(2022)
Response to comment on ‘SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung’
eLife 11:e74951.
https://doi.org/10.7554/eLife.74951