Replication Studies

Latest articles

    1. Cancer Biology

    Replication Study: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

    Xiaochuan Shan et al
    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
    Replication Study
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biochemistry
    2. Cancer Biology

    Replication Study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

    Megan Reed Showalter et al.
    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
    Replication Study
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cancer Biology

    Replication Study: BET bromodomain inhibition as a therapeutic strategy to target c-Myc

    Fraser Aird et al.
    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
    Replication Study
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cancer Biology

    Replication Study: Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs

    Christine Mantis et al.
    Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
    Replication Study
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cancer Biology

    Replication Study: Melanoma genome sequencing reveals frequent PREX2 mutations

    Stephen K Horrigan et al.
    Editors' Summary: The results in this Replication Study could not be interpreted.
    Replication Study
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cancer Biology

    Replication Study: Discovery and preclinical validation of drug indications using compendia of public gene expression data

    Irawati Kandela et al.
    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
    Replication Study
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cancer Biology

    Replication Study: The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

    Stephen K Horrigan, Reproducibility Project: Cancer Biology
    Editors' Summary: The results in this Replication Study could not be interpreted.
    Replication Study
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf