Replication Studies

Latest articles

1. 1. Cancer Biology

   Replication Study: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

   Xiaochuan Shan et al

   Editors' Summary: This Replication Study has reproduced important parts of the original paper.
2. 1. Biochemistry
   2. Cancer Biology

   Replication Study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

   Megan Reed Showalter et al.

   Editors' Summary: This Replication Study has reproduced important parts of the original paper.
3. 1. Cancer Biology

   Replication Study: BET bromodomain inhibition as a therapeutic strategy to target c-Myc

   Fraser Aird et al.

   Editors' Summary: This Replication Study has reproduced important parts of the original paper.
4. 1. Cancer Biology

   Replication Study: Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs

   Christine Mantis et al.

   Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
5. 1. Cancer Biology

   Replication Study: Melanoma genome sequencing reveals frequent PREX2 mutations

   Stephen K Horrigan et al.

   Editors' Summary: The results in this Replication Study could not be interpreted.
6. 1. Cancer Biology

   Replication Study: Discovery and preclinical validation of drug indications using compendia of public gene expression data

   Irawati Kandela et al.

   Editors' Summary: This Replication Study has reproduced important parts of the original paper.
7. 1. Cancer Biology

   Replication Study: The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

   Stephen K Horrigan, Reproducibility Project: Cancer Biology

   Editors' Summary: The results in this Replication Study could not be interpreted.