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Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice
Shun Kishimoto et al.
Using noise suppression, real-time imaging of glucose metabolism is possible by 13C MRI and reveals previously undetected metabolic differences within tumors.
Biochemistry and Chemical Biology
Distinct mechanisms of microRNA sorting into cancer cell-derived extracellular vesicle subtypes
Morayma M Temoche-Diaz et al.
The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells
Shaheen Kabir et al.
Targeting the CRL5 ubiquitin ligase complex in combination with CDK9 or MCL1 inhibition could combat innate and acquired resistance of cancer cells to MCL1-targeting therapeutics.
Brain tumours repurpose endogenous neuron to microglia signalling mechanisms to promote their own proliferation
Kelda Chia et al.
P2ry12-mediated microglial interactions stimulate the proliferation of brain tumour initiating cells.
The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in
Jean-Philippe Parvy et al.
Natural activity of the antimicrobial peptide Defensin includes execution of tumour cell death by tumour necrosis factor in
R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma
Jeroen Overman et al.
Identification of the R(+)-propranolol enantiomer as an inhibitor of the SOX18 transcription factor activity breaks open potential of drug repurposing in vascular diseases.
A positive feedback loop between Myc and aerobic glycolysis sustains tumor growth in a
Kenneth Kin Lam Wong et al.
Specific molecular links that orchestrate growth signals and metabolic reprogramming to achieve tumorigenesis are identified as potential metabolic vulnerabilities in cancer treatment.
Club cells form lung adenocarcinomas and maintain the alveoli of adult mice
Magda Spella et al.
Airway cells are required for the maintenance of the adult mouse lung and for carcinogen-induced lung adenocarcinoma development, and are thus marked therapeutic targets.
NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma
Ganapati V Hegde et al.
TP63 regulates NRG1 in squamous cell cancers, and targeting of NRG1 induces cancer cell differentiation thereby NRG1 is a potential therapeutic target in squamous cell cancers.
Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer
SungEun Kim et al.
Pharmacologic inhibition of DNA methylation restrains the growth of urothelial carcinoma by subtype conversion through heightened stromal Hedgehog pathway activity.
Reproducibility in Cancer Biology
Curated by Roger J Davis et al.
Immunology and Inflammation
Now inviting submissions to our latest Special Issue in Cancer Immunology
Cancer: Acceleration without mutation
Douglas E Brash
University of California, Los Angeles, United States
McGill University, Canada
The Wistar Institute, United States
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