Cancer Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation

   Xiao-Tong Lin et al.

   Using IGF2BP1-PLK1 axis as an example, targeting oncogenic signaling represents a direction treatment for HCC patients with high FBXO45 expression.
2. 1. Cancer Biology
   2. Cell Biology

   Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2

   Taylor P Enrico et al.
3. 1. Cancer Biology

   Glutamine deprivation triggers NAGK-dependent hexosamine salvage

   Sydney Campbell et al.

   Hexosamine salvage through the enzyme N-acetylglucosamine kinase is stimulated in nutrient-limited conditions and supports pancreatic tumor growth.
4. 1. Cancer Biology
   2. Computational and Systems Biology

   Quantitative analysis of tumour spheroid structure

   Alexander P Browning et al.
5. 1. Cancer Biology
   2. Genetics and Genomics

   BRAF^V600E induces reversible mitotic arrest in human melanocytes via microrna-mediated suppression of AURKB

   Andrew S McNeal et al.

   Oncogenic BRAF causes genome duplication and reversible growth arrest in human melanocytes that is conditional on microRNA expression and differentiation state.
6. 1. Cancer Biology
   2. Cell Biology

   Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion

   Akikazu Harada et al.

   Specific localization of KRAS downstream target ARL4C with its novel interacting proteins was the active site of invasion of pancreatic cancer cell and induced metastasis.
7. 1. Cancer Biology
   2. Cell Biology

   Heat Shock Factor 1 (HSF1) cooperates with estrogen receptor α (ERα) in the regulation of estrogen action in breast cancer cells

   Natalia Vydra et al.
8. 1. Cancer Biology

   ZHX2 promotes HIF1α oncogenic signaling in triple-negative breast cancer

   Wentong Fang et al.
9. 1. Cancer Biology
   2. Immunology and Inflammation

   Tumor-derived extracellular vesicles regulate tumor-infiltrating regulatory T cells via the inhibitory immunoreceptor CD300a

   Yuta Nakazawa et al.

   Tumor-infiltrating regulatory T cells are regulated by the immunoreceptor CD300a, which suppresses signals from tumor-derived extracellular vesicles.
10. 1. Cancer Biology

    The role of TAp63γ and P53 point mutations in regulating DNA repair, mutational susceptibility and invasion of bladder cancer cells

    Hsiang-Tsui Wang et al.

    Biochemical analysis shows that muscle-invasive-bladder-cancer cells are deficient in DNA repair and hypermutable, non-muscle-invasive-bladder-cancer cells are proficient in DNA repair, DNA repair capacity is regulated by tumor suppressor TAp63g, and cell invasions are regulated by TAp63g and p53.