Cancer Biology

Latest articles

1. 1. Cancer Biology
   2. Immunology and Inflammation

   The newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer

   Alison Caldwell et al.

   A recently discovered contagious cancer in the Tasmanian devil has the potential to become widespread in the population due to the loss of histocompatibility antigens that are allogeneic to its hosts.
2. 1. Cancer Biology
   2. Immunology and Inflammation

   Contagious Cancers: A ‘devil’ of a problem

   Victoria L Hansen, Robert D Miller

   The discovery of a second facial tumor disease in the Tasmanian devil has provided insights into the emergence of contagious cancers.
3. 1. Cancer Biology
   2. Computational and Systems Biology

   Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes

   Jia-Ren Lin et al.

   t-CyCIF can be used to collect spatially-encoded, multiparametric data from fixed and embedded research or clinical specimens making it possible to probe the organization of tumors and tissues at a single-cell level.
4. 1. Cancer Biology
   2. Stem Cells and Regenerative Medicine

   HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties

   Ethan V Abel et al.
5. 1. Cancer Biology
   2. Cell Biology

   Aurora kinase A localises to mitochondria to control organelle dynamics and energy production

   Giulia Bertolin et al.
6. 1. Cancer Biology
   2. Cell Biology

   An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer

   Ji Li et al.
7. 1. Cancer Biology
   2. Structural Biology and Molecular Biophysics

   Dynamics of human protein kinase Aurora A linked to drug selectivity

   Warintra Pitsawong et al.

   Slow conformational changes after drug binding rationalize selectivity, affinity and long on-target residence time for kinase inhibitors.
8. 1. Cancer Biology

   Pancreatic Cell Fate: To be or not to be

   Zhe Zhang, Elisabeth Hessmann

   Chromatin remodeling processes can drive acinar cell fate decisions.
9. 1. Cancer Biology

   Arid1a restrains Kras-dependent changes in acinar cell identity

   Geulah Livshits et al.

   Arid1a loss in the pancreas enables an irreversible reprogramming of cell fate that is dependent on both cellular and genetic context.
10. 1. Cancer Biology

    BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions

    Nicolas Bery et al.

    A biosensor resource has been developed to monitor the intracellular interactions of RAS family proteins with effector molecules and the effects of inhibitors as an aid to drug development.