Cancer Biology

Latest articles

1. 1. Cancer Biology

   Cancer Immunotherapy: A peptide puzzle

   Jian Guan, Nilabh Shastri

   Why does cancer develop in situations where the immune system is perfectly capable of eliminating it?
2. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma

   Gerard L Brien et al.

   BRD9 provides the first actionable therapeutic target in synovial sarcoma tumours that is both biochemically and functionally linked to the SS18-SSX fusion protein which drives disease development.
3. 1. Cancer Biology
   2. Cell Biology

   Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis

   Stephin J Vervoort et al.

   Global transcriptome analysis reveals that the transcription factor SOX4 can promote breast tumor development via tumor angiogenesis by promoting paracrine signalling through endothelin-1.
4. 1. Cancer Biology

   Rejection of immunogenic tumor clones is limited by clonal fraction

   Ron S Gejman et al.

   A new, high-throughput in vivo MHC-I peptide minigene library platform shows that the naive immune system cannot eliminate cells presenting immunogenic antigens found at low frequencies within a growing tumor.
5. 1. Cancer Biology

   The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells

   Sean W Fanning et al.
6. 1. Cancer Biology

   Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells

   Arun M Unni et al.
7. 1. Cancer Biology

   FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer

   Soledad A Camolotto et al.
8. 1. Cancer Biology

   Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13

   Mei Zeng et al.

   A multi-transcriptional CDKs inhibitor suppresses MYC and induces regression of ovarian tumors, indicating that targeting CDK7, 12, 13 with THZ1 may be an effective approach for treating MYC-dependent malignancies.
9. 1. Cancer Biology
   2. Stem Cells and Regenerative Medicine

   T-ALL leukemia stem cell 'stemness' is epigenetically controlled by the master regulator SPI1

   Haichuan Zhu et al.

   The identification of key determinants of LSC “stemness” and LSC differentiation that is reversible through an epigenetic mechanism may have considerable implications in understanding leukemia and designing effective therapies.
10. 1. Cancer Biology
    2. Genetics and Genomics

    Targets and genomic constraints of ectopic Dnmt3b expression

    Yingying Zhang et al.

    Ectopic expression of Dnmt3b leads to wide-spread CpG island hypermethylation that is largely defined by chromatin state and has some distinct features when compared to the cancer methylome.