Cancer Biology

Latest articles

1. 1. Cancer Biology
   2. Immunology and Inflammation

   Osterix-Cre marks distinct subsets of CD45- and CD45+ stromal populations in extra-skeletal tumors with pro-tumorigenic characteristics

   Biancamaria Ricci et al.

   Osterix, a transcription factor regulating osteoblast differentiation and bone formation, is expressed in subsets of CAFs with osteogenic features and marks tumor infiltrating immune populations enriched in immune suppressive markers.
2. 1. Cancer Biology

   Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma

   Allison N Lau et al.

   Isotope tracing into macromolecules enables functional analysis of metabolism in specific cell populations in tumors and provides insight into metabolic differences between cancer and stromal cells in their endogenous microenvironment.
3. 1. Cancer Biology

   NuRD subunit CHD4 regulates super-enhancer accessibility in Rhabdomyosarcoma and represents a general tumor dependency

   Joana G Marques et al.
4. 1. Cancer Biology

   Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

   Zeyad D Nassar et al.

   DECR1, a rate-limiting enzyme for polyunsaturated fatty acid (PUFA) β-oxidation, is an androgen-repressed gene in prostate cancer cells that limits oxidative stress to promote cancer cell survival.
5. 1. Cancer Biology

   The identification of dual protective agents against cisplatin-induced oto-and nephrotoxicity using the zebrafish model

   Jaime N Wertman et al.
6. 1. Cancer Biology
   2. Computational and Systems Biology

   Identifying prostate cancer and its clinical risk in asymptomatic men using machine learning of high dimensional peripheral blood flow cytometric natural killer cell subset phenotyping data

   Simon P Hood et al.

   Diagnosing the presence and clinical significance of prostate cancer can be achieved using AI-based analysis of peripheral blood natural killer (NK) cell subset profiles.
7. 1. Cancer Biology
   2. Computational and Systems Biology

   Dissecting transcriptional amplification by MYC

   Zuqin Nie et al.

   Synthetic biology experiments show that MYC is a general transcription amplifier acting at two or more sites in the transcription-cycle and that MYC-turnover contributes to its activity.
8. 1. Cancer Biology
   2. Cell Biology

   Tracking cells in epithelial acini by light sheet microscopy reveals proximity effects in breast cancer initiation

   Ashna Alladin et al.

   The presented primary epithelial acinus-based platform for studying interactions between normal and malignant cells will enable in depth analysis of the tumor initiation process on a molecular level.
9. 1. Cancer Biology

   MEIS-mediated suppression of human prostate cancer growth and metastasis through HOXB13-dependent regulation of proteoglycans

   Calvin VanOpstall et al.

   The HOXB13 binding partner MEIS1 suppresses prostate cancer proliferation, invasion, and metastasis by promoting expression of the anti-oncogenic extracellular proteoglycan Decorin.
10. 1. Cancer Biology

    Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531

    CheukMan C Au et al.

    3D culture of breast cancer in biologically relevant ECM potentiates the growth-inhibitory effects of unacylated ghrelin and AZP-531, and clinical response may be predictable based on a MAPK gene signature.