Cancer Biology

Latest articles

1. 1. Cancer Biology
   2. Human Biology and Medicine

   PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis

   Norihiro Yamaguchi et al.

   The gluconeogenic enzyme PCK1 and pyrimidine nucleotide biosynthetic enzyme DHODH drive hypoxic pyrimidine nucleotide biosynthesis and liver metastatic colonization in colorectal cancer, which is therapeutically exploitable by DHODH pharmacologic inhibition.
2. 1. Cancer Biology

   T-cell co-stimulation in combination with targeting FAK drives enhanced anti-tumor immunity

   Marta Canel et al.

   Cancer cell expression of the T-cell co-stimulatory molecule CD80, or treatment with agonistic antibodies targeting the T-cell co-stimulatory receptors OX-40 or 4-1BB, enhances the anti-tumor activity of FAK inhibition.
3. 1. Cancer Biology
   2. Physics of Living Systems

   Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior

   Debanjan Goswami et al.
4. 1. Cancer Biology

   TLE3 loss confers AR inhibitor resistance by facilitating GR-mediated human prostate cancer cell growth

   Sander AL Palit et al.

   A mechanistic link between TLE3 loss and glucocorticoid receptor-mediated androgen receptor inhibitor resistance supports the rationale to target GR during anti-hormonal treatment in castrate-resistant prostate cancer.
5. 1. Cancer Biology
   2. Developmental Biology

   Regulation of zebrafish melanocyte development by ligand-dependent BMP signaling

   Alec K Gramann et al.

   The oncogenic role ligand-dependent BMP signaling plays in suppressing differentiation in melanoma is a reiteration of its physiological roles during melanocyte development.
6. 1. Cancer Biology

   MYC and Twist1 cooperate to drive metastasis by eliciting crosstalk between cancer and innate immunity

   Renumathy Dhanasekaran et al.

   MYC and Twist1 drive metastasis by a novel non-cell-autonomous transcriptional mechanism of eliciting a cytokinome that mediates the crosstalk between cancer cells and macrophages, and its therapeutic blockade inhibits metastasis.
7. 1. Cancer Biology
   2. Immunology and Inflammation

   Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth

   Mark David Hayes et al.

   Natural IgE supports epithelial cell growth and differentiation in healthy skin, but during chronic tissue inflammation, IgE drives tumour outgrowth of epithelial cells harbouring oncogenic mutations.
8. 1. Cancer Biology

   STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells

   Jong Wook Kim et al.
9. 1. Cancer Biology
   2. Cell Biology

   Axon-like protrusions promote small cell lung cancer migration and metastasis

   Dian Yang et al.

   In small cell lung cancer, the transition from a neuroendocrine state to a more neuronal state endows these cancer cells with increased migration and metastatic potential.
10. 1. Cancer Biology

    Siglec1-expressing subcapsular sinus macrophages provide soil for melanoma lymph node metastasis

    Rohit Singh, Beom K Choi

    When pioneer metastatic cells enter a sentinel lymph node through afferent lymphatics subcapsular sinus, macrophages provide them soil to proliferate and colonize lymph node.