Cancer Biology

Latest articles

1. 1. Cancer Biology

   Functional heterogeneity of lymphocytic patterns in primary melanoma dissected through single-cell multiplexing

   Francesca Maria Bosisio et al.
2. 1. Cancer Biology

   Understanding the glioblastoma immune microenvironment as basis for the development of new immunotherapeutic strategies

   Ana Rita Pombo Antunes et al.

   The heterogeneity of immune cell types in glioblastoma tumors depends on the tumor's genetic make-up and treatment status and is an incompletely mined source of novel therapeutic targets.
3. 1. Cancer Biology
   2. Immunology and Inflammation

   Preclinical murine tumor models: a structural and functional perspective

   Marion V Guerin et al.

   Dissecting structural, cellular and molecular differences between transplanted and spontaneous mouse tumor models, highlighting their relevance for predicting the efficacy of anti-cancer treatments in patients.
4. 1. Cancer Biology

   STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells

   Jong Wook Kim et al.

   ST recruitment of STRIPAK facilitates PP2A-mediated dephosphorylation of MAP4K4 and induces cell transformation highlighting that STRIPAK complex plays a key role in defining PP2A specificity and activity.
5. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukaemia stem-like cells

   Ana Filipa Domingues et al.
6. 1. Cancer Biology
   2. Human Biology and Medicine

   PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis

   Norihiro Yamaguchi et al.

   The gluconeogenic enzyme PCK1 and pyrimidine nucleotide biosynthetic enzyme DHODH drive hypoxic pyrimidine nucleotide biosynthesis and liver metastatic colonization in colorectal cancer, which is therapeutically exploitable by DHODH pharmacologic inhibition.
7. 1. Cancer Biology

   T-cell co-stimulation in combination with targeting FAK drives enhanced anti-tumor immunity

   Marta Canel et al.

   Cancer cell expression of the T-cell co-stimulatory molecule CD80, or treatment with agonistic antibodies targeting the T-cell co-stimulatory receptors OX-40 or 4-1BB, enhances the anti-tumor activity of FAK inhibition.
8. 1. Cancer Biology
   2. Physics of Living Systems

   Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior

   Debanjan Goswami et al.
9. 1. Cancer Biology

   TLE3 loss confers AR inhibitor resistance by facilitating GR-mediated human prostate cancer cell growth

   Sander AL Palit et al.

   A mechanistic link between TLE3 loss and glucocorticoid receptor-mediated androgen receptor inhibitor resistance supports the rationale to target GR during anti-hormonal treatment in castrate-resistant prostate cancer.
10. 1. Cancer Biology
    2. Developmental Biology

    Regulation of zebrafish melanocyte development by ligand-dependent BMP signaling

    Alec K Gramann et al.

    The oncogenic role ligand-dependent BMP signaling plays in suppressing differentiation in melanoma is a reiteration of its physiological roles during melanocyte development.