Cancer Biology

Cancer Biology

eLife reviews research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cancer Biology

    KDM5 demethylases suppress R-loop-mediated ‘viral mimicry’ and DNA damage in breast cancer cells

    Lena Lau, Kurt Henderson ... Marie Classon
    KDM5 inhibition/disruption selectively induces R-loop-mediated DNA damage and innate immune activation in breast cancer cells, while sparing normal cells, unveiling a tumor-specific therapeutic vulnerability with broad translational potential.
    1. Cancer Biology

    Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females

    Megan E Patton, Sherwin Kelekar ... Sayeepriyadarshini Anakk
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Cancer Biology
    2. Evolutionary Biology

    Cancer–immune coevolution dictated by antigenic mutation accumulation

    Long Wang, Christo Morison, Weini Huang
    Genetic information in cancer cells reveals the strength of cancer–immune interactions in an individual-based stochastic model, which captures explicit interactions between cancer and effector cells.
    1. Cancer Biology
    2. Evolutionary Biology

    Punctuated mutagenesis promotes multi-step evolutionary adaptation in human cancers

    Christopher Graser, Wenbo Wu ... Franziska Michor
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Telomeres control human telomerase (TERT) expression through non-telomeric TRF2

    Antara Sengupta, Soujanya Vinayagamurthy ... Shantanu Chowdhury
    Telomere length controls hTERT expression by modulating TRF2 distribution and PRC2-mediated repression, highlighting a self-regulatory mechanism in cancer.
    1. Cancer Biology

    Transcription Factor-Dependent Cancers: Targeting chromatin remodeling complexes to treat uveal melanoma

    Jonas A Nilsson
    A novel compound that inhibits the BAF chromatin remodeling complex causes regression in an animal model of the incurable cancer uveal melanoma.
    Version of Record
    Insight
    1. Microbiology and Infectious Disease
    2. Cancer Biology

    RadD from Fusobacterium nucleatum Engages NKp46 to Promote Antitumor Cytotoxicity

    Ahmed Rishiq, Johanna Galski ... Ofer Mandelboim
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Rearrangement of 3D genome organization in breast cancer epithelial - mesenchymal transition and metastasis organotropism

    Priyojit Das, Rebeca San Martin ... Rachel Patton McCord
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid

Senior editors

  1. Eduardo Franco
    McGill University, Canada
  2. Caigang Liu
    Shengjing Hospital of China Medical University, China
  3. Lynne-Marie Postovit
    University of Alberta, Canada
  4. See more editors