Cancer Biology

eLife publishes research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Decisions are made by journal editors who are active researchers in cancer biology.

Latest articles

    1. Cancer Biology
    2. Computational and Systems Biology

    Defining the biological basis of radiomic phenotypes in lung cancer

    Patrick Grossmann et al.
    1. Cancer Biology
    2. Cell Biology

    Mitosis can drive cell cannibalism through entosis

    Joanne Durgan et al.
    Mitosis is found to act as a novel trigger for epithelial cell cannibalism, revealing an important link between cell division and death, of relevance to cancer and chemotherapy.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cancer Biology
    2. Human Biology and Medicine

    Tsc2 disruption in mesenchymal progenitors results in tumors with vascular anomalies overexpressing Lgals3

    Peter J Klover et al.
    Tsc2 inactivation in mouse mesenchymal progenitors produced tumors with vascular anomalies reminiscent of human angiomyolipomas, and a gene expression signature in Tsc2-deficient tissues which included Lgals3, as a novel potential biomarker for TSC1/2 loss.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cancer Biology
    2. Cell Biology

    Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts

    Petra van der Lelij et al.
    Short Report
    Available as authors' accepted manuscript pdf
    1. Cancer Biology

    Essential roles of Caspase-3 in facilitating Myc-induced genetic instability and carcinogenesis

    Ian M Cartwright et al.
    Short Report
    Available as authors' accepted manuscript pdf
    1. Cancer Biology
    2. Cell Biology

    MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect

    Nataly Shtraizent et al.
    Mannose phosphate isomerase is a metabolic enzyme regulating cell survival in both embryonic and cancer cells.
    Research Article Updated
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cancer Biology

    Replication Study: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

    Xiaochuan Shan et al.
    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
    Replication Study
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biochemistry
    2. Cancer Biology

    Replication Study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

    Megan Reed Showalter et al.
    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
    Replication Study
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cancer Biology

    Synergistic interactions with PI3K inhibition that induce apoptosis

    Yaara Zwang et al.
    A geneome-scale shRNA screen identifies five genes whose suppression promotes cell death upon PI3K inhibition both in vitro and in vivo, thus suggesting potential combination therapies involving PI3K inhibition.
    Research Article Updated
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cancer Biology

    Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3

    Ritu Chaudhary et al.
    Functional and mechanistic analysis of p53-regulated lncRNA PINCR and its interacting RNA-binding protein Matrin 3 uncovers context-dependent regulation of specific p53 target genes during DNA damage.
    Research Article Updated
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf

Highlights

    1. Cancer Biology

    Reproducibility in Cancer Biology

    Curated by Roger Davis et al.
    1. Cancer Biology
    2. Cell Biology

    Genetic Diversity: Driving cancer evolution

    Devon M Fitzgerald, Susan M Rosenberg