Cancer Biology

Cancer Biology

eLife publishes research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Decisions are made by journal editors who are active researchers in cancer biology.
Illustration by Davide Bonazzi

Latest articles

    1. Cancer Biology

    A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models

    Yuhan Zhao et al.
    A mouse model reveals that a p53 SNP impacts longevity via modulating the balance of cancer risk and the self-renewal function of stem/progenitor cells, which supports a role of p53 in regulation of longevity.
    1. Cancer Biology

    SPIN1 promotes tumorigenesis by blocking the uL18 (universal large ribosomal subunit protein 18)-MDM2-p53 pathway in human cancer

    Ziling Fang et al.
    SPIN1, a nucleolar protein, plays an oncogenic role by suppressing the tumor suppressor p53's function via regulation of the uL18-MDM2-p53 pathway.
    1. Cancer Biology
    2. Developmental Biology and Stem Cells

    Stem Cell Tumors: Cherub versus brat

    Jennifer A Malin, Claude Desplan
    A long non-coding RNA molecule called cherub is a driver of tumor development.
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    1. Cancer Biology
    2. Developmental Biology and Stem Cells

    The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells

    Lisa Landskron et al.
    Genetic analyses uncovered that the asymmetrically long non-coding RNA cherub is required for brain tumor growth.
    1. Cancer Biology
    2. Cell Biology

    Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling

    Benjamin L Ricca et al.
    In a 3D culture model of breast epithelium, application of a short-timescale compression to single malignant cells promotes the long-timescale development of polarized, growth-arrested structures.
    1. Cancer Biology
    2. Cell Biology

    Laminin signals initiate the reciprocal loop that informs breast-specific gene expression and homeostasis by activating NO, p53 and microRNAs

    Saori Furuta et al.
    Endogenous laminins are necessary to build a functional acinus via generating NO, activating p53, HOXD10 and other positive players, but tumor cells neither make laminin nor generate NO, unless they are reverted to an organized structure.
    1. Cancer Biology

    Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy

    Simeon U Springer et al.
    The creation of a non-invasive assay for detecting urothelial cancer could have a profound impact on how we find and treat the disease.

Highlights

    1. Cancer Biology

    Reproducibility in Cancer Biology

    Curated by Roger Davis et al.

Senior editors

  1. Sean Morrison
    Sean Morrison
    Senior Editor
  2. Charles Sawyers
    Charles Sawyers
    Senior Editor
  3. Jeffrey Settleman
    Senior Editor
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