Cancer Biology

Cancer Biology

eLife reviews research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cancer Biology

    Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics

    Inbal Avraham-Davidi, Simon Mages ... Aviv Regev
    An integrative analysis of scRNA-seq and spatial transcriptomics provides complementary views into the biology of pre-clinical colorectal cancer models in mice with possible applications to the human system.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Degradation of LMO2 in T cell leukaemia results in collateral breakdown of transcription complex partners and causes LMO2-dependent apoptosis

    Naphannop Sereesongsaeng, Carole Bataille ... Terence Rabbitts
    Antibody surrogate degraders of LMO2 indicate that transcription complexes are susceptible to drug discovery and are therefore druggable.
    1. Genetics and Genomics
    2. Cancer Biology

    Early Diagnosis and Prognostic Prediction of Colorectal Cancer through Plasma Methylation Regions

    Lingqin Zhu, Lang Yang ... Jianqiu Sheng
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Cancer Biology

    Mitochondrial Protein Carboxyl-Terminal Alanine-Threonine Tailing Promotes Glioblastoma Tumor Growth by Regulating Mitochondrial Function

    Bei Zhang, Ting Cai ... Zhihao Wu
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Cancer Biology
    2. Evolutionary Biology

    Punctuated mutagenesis promotes multi-step evolutionary adaptation in human cancers

    Christopher Graser, Wenbo Wu ... Franziska Michor
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Cancer Biology

    Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma

    Olivia G Waltner, April A Apfelbaum ... Scott N Furlan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cancer Biology

    Endoscopic liquid biopsies of gastric fluid in a large patient cohort reveal DNA content as a candidate tumor biomarker in gastric cancer

    Francine Carla Cadoná, Thais F Bartelli ... Emmanuel Dias-Neto
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cancer Biology
    2. Cell Biology

    Human RAP2A homolog of the Drosophila asymmetric cell division regulator Rap2l targets the stemness of glioblastoma stem cells

    Maribel Franco, Ricardo Gargini ... Ana Carmena
    Restitution of RAP2A, human homolog of Drosophila asymmetric cell division regulator Rap2l, in glioblastoma neurosphere cultures targets the stemness of glioblastoma stem cells and could contribute to reduce glioblastoma expansion.
    1. Cancer Biology

    Candida albicans drives colorectal cancer progression by inducing hypoxia signaling

    Wanqiu Wang, Mengqi Yang ... Kun Sun
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Cancer Biology
    2. Physics of Living Systems

    Robust assessment of asymmetric division in colon cancer cells

    Domenico Caudo, Chiara Giannattasio ... Mattia Miotto
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Convincing
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Highlights

    1. Cancer Biology

    Reproducibility in Cancer Biology

    Edited by Roger J Davis et al.
    1. Cancer Biology
    2. Computational and Systems Biology

    eLife publishes final papers from the Reproducibility Project: Cancer Biology

    Timothy M Errington, Maya Mathur ... Brian A Nosek
    1. Cancer Biology

    Toxicity: Fishing for protective compounds

    Giuliano Ciarimboli

Senior editors

  1. Yamini Dalal
    National Cancer Institute, United States
  2. Eduardo Franco
    McGill University, Canada
  3. Tony Ng
    King's College London, United Kingdom
  4. See more editors