Cancer Biology

Latest articles

1. 1. Cancer Biology
   2. Cell Biology

   CXCL10/CXCR3 signaling contributes to an inflammatory microenvironment and its blockade enhances progression of murine pancreatic precancerous lesions.

   Veethika Pandey et al.
2. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53

   Liz Hernandez Borrero et al.

   Anti-tumor properties of sub-class of xanthine analogs involve restoration of p53 pathway transcriptome, independent of p53/p73, dependent on ATF3/ATF4 and Noxa in mutated-p53 tumors and the compounds trigger an S-phase checkpoint.
3. 1. Cancer Biology
   2. Computational and Systems Biology

   Structural basis of the effect of activating mutations on the EGF receptor

   Ioannis Galdadas et al.

   Computational methods reveal how mutations affect the conformational landscape of the kinase domain of EGFR resulting in abnormal signaling and provide a structural framework for ongoing drug discovery efforts on mutant-specific EGFR inhibition.
4. 1. Cancer Biology
   2. Medicine

   Association of human breast cancer CD44^-/CD24^- cells with delayed distant metastasis

   Xinbo Qiao et al.
5. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Non-canonical H3K79me2-dependent pathways promote the survival of MLL-rearranged leukemia

   William F Richter et al.

   FLT3-ITD/STAT5A signaling is more sensitive to Dot1L inhibition than the canonical MLL-fusion activated drivers of leukemogenesis, providing a potential therapeutic avenue for one of the most frequent lesions in leukemia.
6. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways

   Ryo Miyamoto et al.

   HOXA9 is a transcriptional maintenance factor for anti-apoptotic genes that accelerate MYC-driven leukemia.
7. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Autoregulatory control of microtubule binding in doublecortin-like kinase 1

   Regina L Agulto et al.
8. 1. Cancer Biology
   2. Developmental Biology

   E2F/Dp inactivation in fat body cells triggers systemic metabolic changes

   Maria Paula Zappia et al.

   The E2F/Dp transcription factors, which are key cell cycle regulators, can also mediate the regulation of carbohydrate metabolism in larva by controlling both systemic trehalose homeostasis and fat storage.
9. 1. Cancer Biology

   An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKi-resistant cells by modulating miR-335 expression

   Polona Safaric Tepes et al.

   Erlotinib-resistant AXL overexpressing cells are present in therapy-naive tumors, and expression of AXL in these cells is regulated through a stochastic mechanism centered on the epigenetic regulation of miR-335.
10. 1. Cancer Biology

    Acid-base transporters and pH dynamics in human breast carcinomas predict proliferative activity, metastasis, and survival

    Nicolai J Toft et al.

    Cellular acidity, capacity for net acid extrusion, and expression of acid-base transporters in human breast carcinomas independently predict variation in proliferative activity, lymph node metastasis, and patient survival.