Cancer Biology

Latest articles

1. 1. Cancer Biology

   KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D

   Sawan Kumar Jha et al.

   Both VEGF-C and VEGF-D can be activated by KLK3/PSA and Cathepsin D, producing two novel VEGF-C forms and the known VEGFR-2-specific form of VEGF-D.
2. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer

   Yun Pyo Kang et al.

   By increasing intracellular cysteine levels, NRF2 engages a tumor suppressive metabolic pathway mediated by cysteine dioxygenase 1.
3. 1. Cancer Biology

   Replication Study: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

   Anthony Essex et al.

   Editors' Summary: This Replication Study has reproduced important parts of the original paper.
4. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs

   Bert van de Kooij et al.

   The human NimA-related kinases (Neks) recognize divergent substrate motifs, and include Nek10 as a dual-specificity serine/tyrosine kinase, and Nek6, Nek7 and Nek9 as amplifiers of the Plk1 phospho-motif.
5. 1. Cancer Biology
   2. Cell Biology

   DDR2 controls breast tumor stiffness and metastasis by regulating integrin mediated mechanotransduction in CAFs

   Samantha VH Bayer et al.

   The action of the collagen receptor DDR2 in CAFs regulates Rap1-Talin1 mediated Integrin mechanotransduction in breast tumors to impact tumor stiffness and metastases.
6. 1. Cancer Biology

   Biomarkers: Improving survival prediction for melanoma

   Mykyta Artomov

   The survival of patients with cutaneous melanoma can be accurately predicted using just four DNA methylation marks.
7. 1. Cancer Biology

   A four-DNA methylation biomarker is a superior predictor of survival of patients with cutaneous melanoma

   Wenna Guo et al.

   This four-DNA methylation signature demonstrates potential as a novel independent prognostic indicator for risk-stratifying patients with CM.
8. 1. Cancer Biology

   NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma

   Ganapati V Hegde et al.
9. 1. Cancer Biology
   2. Cell Biology

   Club cells form lung adenocarcinomas and maintain the alveoli of adult mice

   Magda Spella et al.
10. 1. Cancer Biology
    2. Cell Biology

    Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancer

    Christina R Adams et al.

    The GLI2 transcription factor is a master regulator of the aggressive basal-like subtype of pancreatic cancer and enables adaptation to oncogenic KRAS ablation.