Cancer Biology

Cancer Biology

eLife reviews research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cancer Biology

    CPT1A mediates radiation sensitivity in colorectal cancer

    Zhenhui Chen, Lu Yu ... Yi Ding
    CPT1A downregulation enhances radioresistance in colorectal cancer (CRC) via FOXM1-mediated antioxidant response, making it a potential biomarker for radiosensitivity and a novel target for improving CRC radiotherapy.
    1. Genetics and Genomics
    2. Cancer Biology

    Functional characterization of all CDKN2A missense variants and comparison to in silico models of pathogenicity

    Hirokazu Kimura, Kamel Lahouel ... Nicholas J Roberts
    Revised
    Reviewed Preprint v2
    Updated
    1. Cancer Biology
    2. Evolutionary Biology

    High-density sampling reveals volume growth in human tumours

    Arman Angaji, Michel Owusu ... Johannes Berg
    Spatial genomics reveals the mode of evolution of a tumour based on the positions of mutations in high-resolution samples.
    1. Cancer Biology
    2. Evolutionary Biology

    Cancers adapt to their mutational load by buffering protein misfolding stress

    Susanne Tilk, Judith Frydman ... Dmitri A Petrov
    High mutational load tumors mitigate effects from protein-damaging mutations by up-regulating complexes that buffer against misfolding stress, revealing therapeutic vulnerabilities and suggesting disrupted proteostasis is a hallmark of somatic evolution.
    1. Cancer Biology

    Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies

    Sander Frank, Thomas Persse ... Peter S Nelson
    Not revised
    Reviewed Preprint v1

Senior editors

  1. Utpal Banerjee
    University of California, Los Angeles, United States
  2. Yamini Dalal
    National Cancer Institute, United States
  3. Eduardo Franco
    McGill University, Canada
  4. See more editors