Cancer Biology

Latest articles

1. 1. Cancer Biology

   Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation

   Liuqun Zhao, Tanel Punga, Suparna Sanyal
2. 1. Cancer Biology

   The context-dependent epigenetic and organogenesis programs determine 3D vs. 2D cellular fitness of MYC-driven murine liver cancer cells

   Jun Yang, Jie Fang ... Shondra Pruett-Miller
3. 1. Cancer Biology
   2. Genetics and Genomics

   Combinatorial CRISPR screen reveals FYN and KDM4 as targets for synergistic drug combination for treating triple negative breast cancer

   Tackhoon Kim, Byung-Sun Park ... Timothy Lu

   Pairwise CRISPR screen identified FYN and KDM4 as key regulator of tyrosine kinase inhibitor resistance in triple negative breast cancer (TNBC).
4. 1. Cancer Biology
   2. Evolutionary Biology

   Cancer-immune coevolution dictated by antigenic mutation accumulation

   Long Wang, Christo Morison, Weini Huang
5. 1. Cancer Biology
   2. Genetics and Genomics

   Functional characterization of all CDKN2A missense variants and comparison to in silico models of pathogenicity

   Hirokazu Kimura, Kamel Lahouel ... Nicholas Jason Roberts

   High-throughput characterization of all possible CDKN2A missense variants identifies functionally deleterious variants and establishes accuracy of variant effect predictors.
6. 1. Developmental Biology
   2. Cancer Biology

   VGLL2 and TEAD1 fusion proteins drive YAP/TAZ-independent tumorigenesis by engaging p300

   Susu Guo, Xiaodi Hu ... Junhao Mao
7. 1. Computational and Systems Biology
   2. Cancer Biology

   Decoding Liver Cancer Prognosis: From Multi-omics Subtypes, Prognostic Models to Single Cell Validation

   Yanbin Wang, Yuqi Wu ... Yanmei Zou
8. 1. Genetics and Genomics
   2. Cancer Biology

   Transcriptional pattern enriched for synaptic signaling is associated with shorter survival of patients with high-grade serous ovarian cancer

   Arkajyoti Bhattacharya, Thijs S Stutvoet ... Rudolf SN Fehrmann
9. 1. Cancer Biology
   2. Developmental Biology

   Oncogenic and teratogenic effects of Trp53^Y217C, an inflammation-prone mouse model of the human hotspot mutant TP53^Y220C

   Sara Jaber, Eliana Eldawra ... Franck Toledo

   In a mouse model of the hotspot mutant TP53^Y220C, the mutant p53 exhibited oncogenic gain of function in males and teratogenic gain of function in females, both correlated with inflammation.
10. 1. Cancer Biology

    Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism

    Weijie Wu, Miao Yu ... Hongquan Zhang

    Tumor-suppressive protein FRMD8 inhibits breast cancer progression by regulating the level of ERα and has the possibility to be a potential target for overcoming tamoxifen treatment resistance.