Cancer Biology

Cancer Biology

eLife reviews research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cancer Biology
    2. Cell Biology

    ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma

    Kimberly J Morgan, Karen Doggett ... Joan K Heath
    ELYS, a multifunctional protein with critical roles in the cell cycle, is essential for the vigorous proliferation and survival of difficult-to-treat cancers carrying mutations in the KRAS oncogene, making it a compelling target for novel drug treatments.
    1. Cancer Biology
    2. Microbiology and Infectious Disease

    Beta human papillomavirus 8E6 promotes alternative end joining

    Changkun Hu, Taylor Bugbee ... Nicholas Wallace
    Human papillomavirus type 8 E6 promotes alternative end joining by compromising non-homologous end joining and homologous recombination.
    1. Cancer Biology

    Arginase 1 is a key driver of immune suppression in pancreatic cancer

    Rosa Elena Menjivar, Zeribe C Nwosu ... Marina Pasca di Magliano
    1. Cancer Biology

    Ras/MAPK signalling intensity defines subclonal fitness in a mouse model of hepatocellular carcinoma

    Anthony Lozano, Francois-Régis Souche ... Damien Grégoire
    Specific tissue environments provide selective pressures that give rise to distinct Ras oncogenic dosage in primary liver tumours and their metastatic-like outgrowths.
    1. Cancer Biology

    Oncogenic PKA signaling increases c-MYC protein expression through multiple targetable mechanisms

    Gary KL Chan, Samantha Maisel ... John D Gordan
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Inducible lncRNA transgenic mice reveal continual role of HOTAIR in promoting breast cancer metastasis

    Qing Ma, Liuyi Yang ... Howard Y Chang
    HOTAIR is required in an ongoing manner when it regulates epigenetic status and reprograms cancer cell gene expression in promoting breast cancer metastasis.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth

    Luca Costantino, Stefania Ferrari ... Maria Paola Costi
    The dimer destabilizers cause a dimer-to-monomer equilibrium shift favoring the human thymidylate synthase monomer more degradable by the proteasome, thus breaking the long-standing link between inhibition and enhanced expression of the protein to fight cancer drug resistance.
    1. Cancer Biology
    2. Immunology and Inflammation

    Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors

    Matheswaran Kandasamy, Uzi Gileadi ... Vincenzo Cerundolo
    Immunization with NY-ESO-1 S-FLU virus elicits a robust NY-ESO-1-specific CTL response and suppresses the NY-ESO-1-expressing tumour development and spontaneous metastasis.

Senior editors

  1. Utpal Banerjee
    University of California, Los Angeles, United States
  2. Wafik S El-Deiry
    Brown University, United States
  3. Eduardo Franco
    McGill University, Canada
  4. See more editors