Cancer Biology

Latest articles

1. 1. Cancer Biology

   Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment

   Alba Nicolas-Boluda et al.

   Tumor stiffness blocks T cell migration in tumors.
2. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Single-PanIN-seq unveils that ARID1A deficiency promotes pancreatic tumorigenesis by attenuating KRAS-induced senescence

   Shou Liu et al.

   ARID1A deficiency in SWI/SNF complex promotes pancreatic tumor development by upregulating ALDH protein levels to effectively reduce cellular reactive oxygen species levels, leading to the significant attenuation of oncogenic KRAS-induced senescence.
3. 1. Cancer Biology

   Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction

   M Ines Pascoal Ramos et al.
4. 1. Cancer Biology

   Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer

   Yusuke Inoue et al.
5. 1. Cancer Biology
   2. Cell Biology

   KSR1- and ERK-dependent translational regulation of the epithelial-to-mesenchymal transition

   Chaitra Rao et al.

   A key Ras-driven signaling pathway stimulates the preferential translation of an effector, EPSTI1, that is both necessary and sufficient for the epithelial-to-mesenchymal transition-like phenotype in colorectal cancer cells.
6. 1. Cancer Biology

   A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis

   Jia Li et al.

   A genome-wide in vivo CRISPR screen identifies an IL-20/IL20RA-mediated crosstalk between peritoneum mesothelial cells and ovarian cancer cells that promotes the formation of M1-like macrophages to prevent ovarian cancer metastasis.
7. 1. Cancer Biology

   Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer

   Andrea Sacchetti et al.

   Colon cancer cells disseminate and colonize distant organ sites along the invasion-metastasis cascade by transiently activating intermediate epithelial to mesenchymal transition states through distinct transcriptional trajectories.
8. 1. Cancer Biology
   2. Stem Cells and Regenerative Medicine

   RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis

   Máté Nászai et al.
9. 1. Cancer Biology
   2. Cell Biology

   A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma

   Alvaro Gonzalez Rajal et al.

   Platinum chemotherapy resistance is a complex process involving multiple signalling pathways and a novel, non-genetic, cell cycle-dependent mechanism that promotes tumour regrowth and highlights potential complications for combination therapies in human lung adenocarcinoma.
10. 1. Cancer Biology
    2. Cell Biology

    PHAROH lncRNA regulates Myc translation in hepatocellular carcinoma via sequestering TIAR

    Allen T Yu et al.

    PHAROH lncRNA is upregulated in hepatocellular carcinoma and functions by sequestering the translational suppressor TIAR via a 71 nucleotide hairpin to regulate c-MYC translation.