Cancer Biology

Latest articles

1. 1. Cancer Biology

   PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP

   Jiongke Wang, Yujie Shi ... Qianming Chen
2. 1. Cancer Biology

   Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics

   Inbal Avraham-Davidi, Simon Mages ... Aviv Regev
3. 1. Cancer Biology

   Multiethnic radiogenomics reveals low-abundancy microRNA signature in plasma-derived extracellular vesicles for early diagnosis and subtyping of pancreatic cancer

   Wenjie Shi, Jianying Xu ... Ulf Dietrich Kahlert
4. 1. Cancer Biology

   Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinoma

   Yang Peng, Jing Yang ... Liang Weng

   Derived from scRNA-seq, SLC26A3 is a potential therapeutic target to improve the efficacy of immunotherapy, as well as a potential diagnostic indicator to reduce post-surgical upstaging, for cervical adenocarcinoma.
5. 1. Cancer Biology

   Propionyl-CoA carboxylase subunit B regulates anti-tumor T cells in a pancreatic cancer mouse model

   Han V Han, Richard Efem ... Richard Z Lin

   Genome-wide CRISPR screen identified propionyl-CoA subunit B as a key regulator for anti-tumor T-cell activity in pancreatic cancer, which holds promise for advancing immunotherapy strategies in curing pancreatic cancer.
6. 1. Cancer Biology
   2. Immunology and Inflammation

   Unraveling the power of NAP-CNB’s machine learning-enhanced tumor neoantigen prediction

   Almudena Mendez-Perez, Andres M Acosta-Moreno ... Esteban Veiga

   NAP-CNB, a machine learning platform, accurately identifies tumor neoantigens, where higher tumor expression correlates with optimal antitumor activity, and multiantigen vaccination enhances immune responses.
7. 1. Cancer Biology
   2. Cell Biology

   Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis

   Zuzana Outla, Gizem Oyman-Eyrilmez ... Martin Gregor

   Plectin drives hepatocellular carcinoma progression and metastasis through cytoskeletal reorganization and oncogenic signaling, making it a promising therapeutic target for overcoming therapy resistance.
8. 1. Cancer Biology

   In vivo targeted and deterministic single cell malignant transformation

   Pierluigi Scerbo, Benjamin Tisserand ... Bertrand Ducos
9. 1. Cancer Biology
   2. Stem Cells and Regenerative Medicine

   Regulation of lung cancer initiation and progression by the stem cell determinant Musashi

   Alison G Barber, Cynthia M Quintero ... Tannishtha Reya

   The stem cell signal Msi2 plays a dual role in lung cancer, acting as a signal that is not only essential for initiation, but also for propagation of the tumor.
10. 1. Cancer Biology

    Notch signaling maintains a progenitor-like subclass of hepatocellular carcinoma

    Kerstin Seidel, Robert Piskol ... Chris Siebel