Cancer Biology

Latest articles

1. 1. Cancer Biology

   Tumor-promoting function of apoptotic caspases by an amplification loop involving ROS, macrophages and JNK in Drosophila

   Ernesto Pérez et al.

   The oncogenic Ras^V12 keeps cells mutant for the tumor suppressor scribble in an undead-like condition, which is required for an amplification loop that promotes tumorigenesis.
2. 1. Cancer Biology

   A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancer

   Song Liu et al.

   Coregulators mediate selective interactions between DNA-bound androgen receptor and other transcription factors, which control distinct prostate cancer biology, suggesting disruption of critical interactions in these complexes as a novel therapeutic strategy.
3. 1. Cancer Biology
   2. Cell Biology

   MELK is not necessary for the proliferation of basal-like breast cancer cells

   Hai-Tsang Huang et al.

   The inhibitory or deletion effect of MELK does not impair the proliferation of basal-like breast cancer cell lines.
4. 1. Biochemistry
   2. Cancer Biology

   The DREAM complex through its subunit Lin37 cooperates with Rb to initiate quiescence

   Christina FS Mages et al.

   Lin37 is essential for cell-cycle gene repression by the DREAM complex in cellular quiescence and a combined loss of Lin37 and Rb prevents cell-cycle exit in response to growth-limiting signals.
5. 1. Cancer Biology

   FXR1 regulates transcription and is required for growth of human cancer cells with TP53/FXR2 homozygous deletion

   Yichao Fan et al.

   Functional and mechanistic analyses of cancer cells containing homozygous deletion of TP53 and FXR2 reveal that inhibition of FXR1 blocks cell proliferation in a collateral lethality manner, opening an avenue to develop therapies targeting such cancers.
6. 1. Cancer Biology

   Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer

   Neel Shah et al.

   Epigenetic regulation of the glucocorticoid receptor in castration-resistant prostate cancer can be targeted via the use of BET bromodomain inhibitors.
7. 1. Cancer Biology
   2. Computational and Systems Biology

   Defining the biological basis of radiomic phenotypes in lung cancer

   Patrick Grossmann et al.

   Radiomics allows automated quantification of the radiographic phenotype of a tumor across diverse patient cohorts and is connected to the underlying molecular pathway activities, which together determine the clinical outcome.
8. 1. Cancer Biology

   Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition

   Alexander Muir et al.

   Cell culture models widely used in cancer research do not reflect metabolism in tumors; by altering culture systems to better model tumor metabolism we find that environmental cystine promotes tumor glutamine metabolism.
9. 1. Cancer Biology
   2. Computational and Systems Biology

   Radiomics: Rethinking the role of clinical imaging

   James PB O'Connor

   Radiomics has the potential to improve the management of cancer patients, but further research is required before it can be adopted into routine clinical practice.
10. 1. Cancer Biology
    2. Cell Biology

    PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex

    Arman Javadi et al.

    PTEN organizes multicellular architecture by non-catalytic scaffolding of spatially localized β-Arrestin1/ARHGAP21/Cdc42 protein complexes to control mitotic spindle orientation, multicellular configuration and lumen formation.