Cancer Biology

Latest articles

1. 1. Cancer Biology
   2. Developmental Biology

   Coopted temporal patterning governs cellular hierarchy, heterogeneity and metabolism in Drosophila neuroblast tumors

   Sara Genovese et al.

   About twenty temporal patterning genes are identified that drive an irreversible differentiation trajectory governing the heterogeneity and proliferative properties of cells in neural tumors with an early developmental origin.
2. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS

   Mary McMahon et al.

   Cancer-associated changes in small nucleolar RNAs and site-specific pseudouridine modifications impact ribosome activity.
3. 1. Cancer Biology
   2. Cell Biology

   Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin

   Qi Deng et al.

   Cartilage and bone tumors arise from chondrocyte or osteoblast progenitors but not differentiated cells or multipotent mesenchymal stem cells (MSCs) via the IHH-Wnt/β-Catenin pathway.
4. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Distinct mechanisms of microRNA sorting into cancer cell-derived extracellular vesicle subtypes

   Morayma M Temoche-Diaz et al.

   Biochemical fractionation of vesicle sub-populations and in vitro reconstitution studies reveal that Lupus La protein mediates the selective sorting of miR-122 into extracellular vesicles in vitro and in vivo.
5. 1. Cancer Biology

   FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy

   Carlos J Diaz Osterman et al.

   Genomic gains in ovarian cancer can promote cisplatin resistance via a FAK, Wnt/beta-catenin and Myc signaling pathway supporting pluripotency genes and tumorspheres that can acquire FAK dependence for survival.
6. 1. Cancer Biology

   Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance

   Matthew F Pech et al.

   CRISPR/Cas9 screens reveal a role for the ubiquitin ligase substrate adaptor DCAF15 in the immune surveillance of cancer cells by natural killer cells.
7. 1. Cancer Biology

   Mutationally-activated PI3’-kinase-α promotes de-differentiation of lung tumors initiated by the BRAF^V600E oncoprotein kinase

   J Edward van Veen et al.

   Two of the most commonly mutated growth factor pathways induce a deadly feature of lung adenocarcinoma.
8. 1. Cancer Biology
   2. Cell Biology

   Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress

   Anna Shemorry et al.

   Biochemical and biological studies reveal that caspases feed back onto the Unfolded Protein Response by cleaving the ER-stress sensor IRE1 to produce a cytoprotective N-terminal fragment that inhibits BAX-dependent apoptosis.
9. 1. Cancer Biology

   Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice

   Shun Kishimoto et al.

   Using noise suppression, real-time imaging of glucose metabolism is possible by 13C MRI and reveals previously undetected metabolic differences within tumors.
10. 1. Cancer Biology
    2. Cell Biology

    The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells

    Shaheen Kabir et al.

    Targeting the CRL5 ubiquitin ligase complex in combination with CDK9 or MCL1 inhibition could combat innate and acquired resistance of cancer cells to MCL1-targeting therapeutics.