Cancer Biology

Latest articles

1. 1. Cancer Biology

   KDM5 demethylases suppress R-loop-mediated ‘viral mimicry’ and DNA damage in breast cancer cells

   Lena Lau, Kurt Henderson ... Marie Classon

   KDM5 inhibition/disruption selectively induces R-loop-mediated DNA damage and innate immune activation in breast cancer cells, while sparing normal cells, unveiling a tumor-specific therapeutic vulnerability with broad translational potential.
2. 1. Cancer Biology

   Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females

   Megan E Patton, Sherwin Kelekar ... Sayeepriyadarshini Anakk
3. 1. Cancer Biology
   2. Evolutionary Biology

   Cancer–immune coevolution dictated by antigenic mutation accumulation

   Long Wang, Christo Morison, Weini Huang

   Genetic information in cancer cells reveals the strength of cancer–immune interactions in an individual-based stochastic model, which captures explicit interactions between cancer and effector cells.
4. 1. Cancer Biology
   2. Evolutionary Biology

   Punctuated mutagenesis promotes multi-step evolutionary adaptation in human cancers

   Christopher Graser, Wenbo Wu ... Franziska Michor
5. 1. Cancer Biology

   Low-dose chemotherapy combined with delayed immunotherapy in the neoadjuvant treatment of non-small cell lung cancer and dynamic monitoring of the drug response in peripheral blood

   Chaoyang Liang, Qi Song ... Bo Yang
6. 1. Cancer Biology

   Mitochondrial stress-induced protein carboxyl-terminal alanine threonine tailing (msiCAT-tailing) facilitates glioblastoma tumorigenesis through the modulation of mitochondrial functions

   Bei Zhang, Ting Cai ... Zhihao Wu
7. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Telomeres control human telomerase (TERT) expression through non-telomeric TRF2

   Antara Sengupta, Soujanya Vinayagamurthy ... Shantanu Chowdhury

   Telomere length controls hTERT expression by modulating TRF2 distribution and PRC2-mediated repression, highlighting a self-regulatory mechanism in cancer.
8. 1. Cancer Biology

   Transcription Factor-Dependent Cancers: Targeting chromatin remodeling complexes to treat uveal melanoma

   Jonas A Nilsson

   A novel compound that inhibits the BAF chromatin remodeling complex causes regression in an animal model of the incurable cancer uveal melanoma.
9. 1. Microbiology and Infectious Disease
   2. Cancer Biology

   RadD from Fusobacterium nucleatum Engages NKp46 to Promote Antitumor Cytotoxicity

   Ahmed Rishiq, Johanna Galski ... Ofer Mandelboim
10. 1. Chromosomes and Gene Expression
    2. Cancer Biology

    Rearrangement of 3D genome organization in breast cancer epithelial - mesenchymal transition and metastasis organotropism

    Priyojit Das, Rebeca San Martin ... Rachel Patton McCord