Cancer Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   USP28 deletion and small molecule inhibition destabilises c-MYC and elicits regression of squamous cell lung carcinoma

   E Josue Ruiz et al.
2. 1. Cancer Biology
   2. Cell Biology

   Fine-tuned repression of Drp1-driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformation

   Brian Spurlock et al.

   A mitochondria-based 'priming' of stemness happens by fine-tuned repression of the level or activity of the master regulator of mitochondrial fission, Drp1, which supports carcinogen-induced transformation in a keratinocyte model.
3. 1. Cancer Biology

   Lipid droplets and ferritin heavy chain: a devilish liaison in human cancer cell radioresistance

   Luca Tirinato et al.

   Lipid Droplet accumulation is a fingerprint shared by different human cancer radioresistant cells and their biogenesis strongly depend on FTH1 presence.
4. 1. Cancer Biology
   2. Cell Biology

   Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion

   Akikazu Harada et al.
5. 1. Cancer Biology
   2. Medicine

   Mutation analysis links angioimmunoblastic T-cell lymphoma to clonal hematopoiesis and smoking

   Shuhua Cheng et al.

   Comparative analysis establishes genetic links among angioimmunoblastic T-cell lymphoma (AITL), clonal hematopoiesis, and concomitant hematologic malignancies, and provides insights into the cell of origin, etiology, and biomarker discovery for AITL.
6. 1. Cancer Biology
   2. Genetics and Genomics

   Risk Modeling: Predicting cancer risk based on family history

   Michelle F Jacobs

   A new software package provides more accurate cancer risk prediction profiles and has the ability to integrate more genes and cancer types in the future.
7. 1. Cancer Biology
   2. Genetics and Genomics

   Multi-syndrome, multi-gene risk modeling for individuals with a family history of cancer with the novel R package PanelPRO

   Gavin Lee et al.

   A comprehensive package for pedigree-based risk modeling, with a highly optimized computational back-end, extends existing models beyond syndrome-specific approaches and incorporates data from panel studies by allowing for an arbitrary number of gene and syndrome associations.
8. 1. Cancer Biology

   Innate immune activation by checkpoint inhibition in human patient-derived lung cancer tissues

   Teresa WM Fan et al.

   Pembrolizumab activates innate immune metabolism and function in primary human non-small cell lung cancer, whereas Pembrolizumab and beta-glucan synergize in enhancing immune metabolism and tumoridical action in brain-metastasized lung cancer.
9. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation

   Lizhi He et al.

   YAP and TAZ, the ultimate targets of the Hippo signaling pathway, are transcriptional co-activators of AP-1 proteins and STAT3 through which they are important for breast cellular transformation.
10. 1. Cancer Biology
    2. Medicine

    Cancer Immunotherapy: A promising platform for predicting toxicity

    Maria Ochoa de Olza

    Organ-on-chip approaches could help researchers to better predict the toxicity of cancer immunotherapy drugs.