Cancer Biology

Cancer Biology

eLife reviews research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cell Biology
    2. Cancer Biology

    PRMT1-Mediated Metabolic Reprogramming Promotes Leukemogenesis

    Hairui Su, Yong Sun ... Xinyang Zhao
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cancer Biology

    Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab-resistant HER2-positive breast cancer

    Yijia Hua, Ningjun Duan ... Yongmei Yin
    Targeting cysteine metabolism could provide novel strategies for treating trastuzumab-resistant HER2-positive breast cancer.
    1. Cancer Biology

    Reduced mitochondrial transcription sensitizes acute myeloid leukemia cells to BCL-2 inhibition

    Laleh S Arabanian, Jenni Adamsson ... Claes M Gustafsson
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cancer Biology

    Ferroptosis-related genes mediate tumor microenvironment and prognosis in triple-negative breast cancer via integrated RNA-seq analysis

    Xuantong Gong, Lishuang Gu ... Yong Wang
    Integrated single-cell RNA-seq analysis identifies ferroptosis-driven tumor microenvironment features, enabling a prognostic risk model and therapeutic targets to advance precision medicine for triple-negative breast cancer.
    1. Cancer Biology
    2. Cell Biology

    Image-based identification and isolation of micronucleated cells to dissect cellular consequences

    Lucian DiPeso, Sriram Pendyala ... Emily M Hatch
    The development of an automated micronucleus segmentation program enables population-level comparisons between cells with and without micronuclei and defines a highly limited response to micronucleus formation or rupture.
    1. Cell Biology
    2. Cancer Biology

    Uev1A counteracts oncogenic Ras stimuli in both polyploid and diploid cells

    Qi Zhang, Yunfeng Wang ... Shaowei Zhao
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cancer Biology

    NOLC1 Suppresses Immuno-chemotherapy by Inhibiting p53-mediated Ferroptosis in Gastric Cancer

    Shengsheng Zhao, Ji Lin ... Weijian Sun
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Solid
    1. Cancer Biology

    Inhibition of p38-MK2 pathway enhances the efficacy of microtubule inhibitors in breast cancer cells

    Yu-Chia Chen, Mamoru Takada ... Aussie Suzuki
    Inhibiting the p38 MAPK-MK2 signaling pathway significantly boosts the efficacy of microtubule-targeting agents specifically in breast cancer cells, highlighting a potential new therapeutic strategy for improved cancer treatment.
    1. Cell Biology
    2. Cancer Biology

    GMCL1 Controls 53BP1 Stability and Modulates Paclitaxel Sensitivity in Cancer

    Yuki Kito, Tania J González-Robles ... Michele Pagano
    Not revised
    Reviewed Preprint v1
    • Inadequate
    1. Cancer Biology
    2. Medicine

    Molecular feature-based classification of retroperitoneal liposarcoma: a prospective cohort study

    Mengmeng Xiao, Xiangji Li ... Li Min
    Identification of two molecularly distinct retroperitoneal liposarcoma subtypes, stratifiable via LEP and PTTG1 biomarkers, enables prognosis prediction and informs precision surgical strategies to improve clinical outcomes.
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Highlights

    1. Cancer Biology

    Reproducibility in Cancer Biology

    Edited by Roger J Davis et al.
    1. Cancer Biology
    2. Computational and Systems Biology

    eLife publishes final papers from the Reproducibility Project: Cancer Biology

    Timothy M Errington, Maya Mathur ... Brian A Nosek
    1. Cancer Biology

    Toxicity: Fishing for protective compounds

    Giuliano Ciarimboli

Senior editors

  1. Yamini Dalal
    National Cancer Institute, United States
  2. Eduardo Franco
    McGill University, Canada
  3. Tony Ng
    King's College London, United Kingdom
  4. See more editors