Cancer Biology

Latest articles

1. 1. Cancer Biology

   Replication Study: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

   Hongyan Wang et al.

   Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
2. 1. Cancer Biology

   Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma

   Chun-Chun Cheng et al.

   The cancer testis antigen COX6B2 enhances cytochrome c oxidase activity thereby promoting proliferation and survival in cancer cells and represents a therapeutic target for inhibiting oxidative phosphorylation selectively in tumors.
3. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B

   Pieter A Roelofs et al.

   The antiviral and genomic DNA deaminase APOBEC3B is repressed in normal cells by PRC1.6/E2F6 and DREAM/E2F4 complexes and deregulation of this axis provides a unifying mechanism for overexpression in cancer.
4. 1. Cancer Biology
   2. Computational and Systems Biology

   Dynamics of nevus development implicate cell cooperation in the growth arrest of transformed melanocytes

   Rolando Ruiz-Vega et al.

   Spontaneous growth arrest of transformed melanocytes (resulting in benign “moles”) does not result from cell-autonomous oncogene-induced senescence, but can be explained by collective mechanisms used in normal tissue size control.
5. 1. Cancer Biology

   Repurposing of KLF5 activates a cell cycle signature during the progression from a precursor state to oesophageal adenocarcinoma

   Connor Rogerson et al.

   Genome-wide redistribution of KLF5 binding leads to activation of a cell cycle gene expression programme and proliferation control in oesophageal cancer.
6. 1. Cancer Biology
   2. Cell Biology

   Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis

   Yen-Lin Huang et al.

   Inhibition of ITGA2-mediated cancer cell-collagen interaction or targeting focal adhesion kinase activity may present an opportunity for therapeutic intervention of metastatic spread in ovarian cancer.
7. 1. Cancer Biology
   2. Cell Biology

   A versatile system to record cell-cell interactions

   Rui Tang et al.
8. 1. Cancer Biology

   A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer

   Haojie Jin et al.

   Combination of glutaminase inhibitor CB-839 and ASCT2 inhibitor V-9302 showed efficient antitumor effect against glutamine addicted liver cancer cells via glutathione depletion and reactive oxygen species (ROS) induction.
9. 1. Cancer Biology
   2. Stem Cells and Regenerative Medicine

   A single-cell atlas of the mouse and human prostate reveals heterogeneity and conservation of epithelial progenitors

   Laura Crowley et al.

   Single-cell analyses identify distinct epithelial populations that are conserved between the adult mouse and human prostate, including populations with properties of multipotent progenitors in organoid formation and tissue reconstitution assays.
10. 1. Cancer Biology
    2. Cell Biology

    IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation

    Li Pan et al.

    Unbiased analyses highlight context-specific crosstalk between Notch, DNA damage response genes, and PP2A, and provide a roadmap for understanding how Notch induces squamous cell differentiation.