Cancer Biology

Latest articles

1. 1. Cancer Biology

   Differentiated glioma cell-derived fibromodulin activates integrin-dependent Notch signaling in endothelial cells to promote tumor angiogenesis and growth

   Shreoshi Sengupta et al.

   Comprehensive proteomic investigation and functional studies unravel an essential role of differentiated glioma cell-secreted fibromodulin (FMOD) in regulating glioblastoma tumor growth by inducing angiogenesis by activating integrin-dependent Notch signaling in endothelial cells, highlighting FMOD as a potential therapeutic target.
2. 1. Cancer Biology

   Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery

   Laura M Sipe et al.
3. 1. Cancer Biology
   2. Cell Biology

   Global cellular response to chemical perturbation of PLK4 activity and abnormal centrosome number

   Johnny M Tkach et al.

   Genome-wide CRISPR screens in human cells identifies a role for TRIM37 in growth arrest after chemical inhibition of PLK4.
4. 1. Cancer Biology
   2. Cell Biology

   Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation

   Haoran Zhu et al.

   Cystathionine-β-synthase is a novel metabolic regulator of AKT-induced senescence and a potential tumor suppressor in gastric cancer pathogenesis which can be harnessed to target PI3K/AKT-driven cancers.
5. 1. Cancer Biology
   2. Cell Biology

   The integrated stress response remodels the microtubule organizing center to clear unfolded proteins following proteotoxic stress

   Brian Hurwitz et al.
6. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells

   David J Hosfield et al.

   Effective antiestrogens engage a new structural interaction to improve therapeutic antagonism in hormone-resistant breast cancer cells expressing Y537S estrogen receptor alpha.
7. 1. Cancer Biology
   2. Computational and Systems Biology

   Individualized discovery of rare cancer drivers in global network context

   Iurii Petrov, Andrey Alexeyenko

   Method NEAdriver employs knowledge from global networks to predict novel cancer driver genes in an individualized manner, which is done by accounting for mutations’ co-occurrence in each tumor genome and rigorous statistical evaluation.
8. 1. Cancer Biology
   2. Cell Biology

   Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice

   Edward Fielder et al.

   Late effects of radiation therapy in mice can be prevented by treatment with either senolytics navitoclax or quercetin plus dasatinib or the senostatic metformin.
9. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor-targeting therapies

   Justin H Hwang et al.

   A comprehensive molecular interrogation of CREB5 interactions identified changes in protein and chromatin interactions of FOXA1 that promoted therapy resistance in prostate cancer cells.
10. 1. Cancer Biology
    2. Computational and Systems Biology

    Regulation of protein complex partners as a compensatory mechanism in aneuploid tumors

    Gökçe Senger et al.

    Coordinated regulation of co-complex members compensates for aneuploidy-induced stoichiometric imbalances in human cancer.