Cancer Biology

Cancer Biology

eLife reviews research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cancer Biology

    PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP

    Jiongke Wang, Yujie Shi ... Qianming Chen
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Incomplete
    1. Cancer Biology

    Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics

    Inbal Avraham-Davidi, Simon Mages ... Aviv Regev
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cancer Biology

    Multiethnic radiogenomics reveals low-abundancy microRNA signature in plasma-derived extracellular vesicles for early diagnosis and subtyping of pancreatic cancer

    Wenjie Shi, Jianying Xu ... Ulf Dietrich Kahlert
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cancer Biology

    Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinoma

    Yang Peng, Jing Yang ... Liang Weng
    Derived from scRNA-seq, SLC26A3 is a potential therapeutic target to improve the efficacy of immunotherapy, as well as a potential diagnostic indicator to reduce post-surgical upstaging, for cervical adenocarcinoma.
    1. Cancer Biology

    Propionyl-CoA carboxylase subunit B regulates anti-tumor T cells in a pancreatic cancer mouse model

    Han V Han, Richard Efem ... Richard Z Lin
    Genome-wide CRISPR screen identified propionyl-CoA subunit B as a key regulator for anti-tumor T-cell activity in pancreatic cancer, which holds promise for advancing immunotherapy strategies in curing pancreatic cancer.
    1. Cancer Biology
    2. Immunology and Inflammation

    Unraveling the power of NAP-CNB’s machine learning-enhanced tumor neoantigen prediction

    Almudena Mendez-Perez, Andres M Acosta-Moreno ... Esteban Veiga
    NAP-CNB, a machine learning platform, accurately identifies tumor neoantigens, where higher tumor expression correlates with optimal antitumor activity, and multiantigen vaccination enhances immune responses.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Cancer Biology
    2. Cell Biology

    Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis

    Zuzana Outla, Gizem Oyman-Eyrilmez ... Martin Gregor
    Plectin drives hepatocellular carcinoma progression and metastasis through cytoskeletal reorganization and oncogenic signaling, making it a promising therapeutic target for overcoming therapy resistance.
    1. Cancer Biology

    In vivo targeted and deterministic single cell malignant transformation

    Pierluigi Scerbo, Benjamin Tisserand ... Bertrand Ducos
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Incomplete
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    Regulation of lung cancer initiation and progression by the stem cell determinant Musashi

    Alison G Barber, Cynthia M Quintero ... Tannishtha Reya
    The stem cell signal Msi2 plays a dual role in lung cancer, acting as a signal that is not only essential for initiation, but also for propagation of the tumor.
    1. Cancer Biology

    Notch signaling maintains a progenitor-like subclass of hepatocellular carcinoma

    Kerstin Seidel, Robert Piskol ... Chris Siebel
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing

Senior editors

  1. Yamini Dalal
    National Cancer Institute, United States
  2. Wafik S El-Deiry
    Brown University, United States
  3. Eduardo Franco
    McGill University, Canada
  4. See more editors