Cancer Biology

Latest articles

1. 1. Cancer Biology
   2. Cell Biology

   Chimeric antigen receptors that trigger phagocytosis

   Meghan A Morrissey et al.

   A family of engineered immune receptors trigger internalization of cancer cells and antigen-coated targets.
2. 1. Cancer Biology
   2. Structural Biology and Molecular Biophysics

   Dynamics of human protein kinase Aurora A linked to drug selectivity

   Warintra Pitsawong et al.
3. 1. Cancer Biology
   2. Immunology and Inflammation

   Tumor-derived CSF-1 induces the NKG2D ligand RAE-1δ on tumor-infiltrating macrophages

   Thornton W Thompson et al.

   Macrophages respond to elevated levels of CSF-1 in tumor micro-environments by expressing a ligand for the NKG2D immunoreceptor.
4. 1. Cancer Biology
   2. Developmental Biology

   PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis

   Genevieve C Kendall et al.

   The basic helix-loop-helix transcription factor, HES3, acts downstream of the PAX3-FOXO1 fusion oncogene to impair muscle differentiation and promote tumorigenesis in rhabdomyosarcoma, a childhood muscle cancer.
5. 1. Cancer Biology
   2. Cell Biology

   The cJUN NH₂-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation

   Nomeda Girnius et al.

   Mutational inactivation of the JNK signaling pathway causes genomic instability and breast cancer development.
6. 1. Cancer Biology

   Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation

   Veronique Nogueira et al.

   Exploiting the metabolic consequences of Akt activation in prostate cancer for therapeutic interventions that circumvent Akt inhibition therapy.
7. 1. Cancer Biology
   2. Human Biology and Medicine

   MPDZ promotes DLL4-induced Notch signaling during angiogenesis

   Fabian Tetzlaff et al.

   The multiple PDZ domain protein recruits Notch ligands to Nectin-2, which increases Notch signaling activity during angiogenesis.
8. 1. Cancer Biology
   2. Cell Biology

   Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface

   Jeroen Claus et al.

   The clinically approved HER2 inhibitor lapatinib causes HER2 and HER3 kinase domains to dimerise in a non-canonical, symmetric orientation, providing a platform for oligomerisation and predisposing to receptor-driven cell proliferation.
9. 1. Cancer Biology
   2. Cell Biology

   Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation

   Pirita Pekkonen et al.

   The melanoma cell interaction with lymphatic endothelial cells promotes melanoma metastasis by inducing a reversible switch to invasively sprouting melanoma cells.
10. 1. Cancer Biology
    2. Cell Biology

    Wnt5a signaling induced phosphorylation increases APT1 activity and promotes melanoma metastatic behavior

    Rochelle Shirin Sadeghi et al.

    Phosphorylation of serine residues 209 and 210 on APT1 increases its depalmitoylating activity, promoting Wnt5a mediated melanoma cell invasion.