Cancer Biology

Latest articles

1. 1. Cancer Biology

   Integrin β4 promotes DNA damage drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/Rac1

   Huan Fang, Wenlong Ren ... Ceshi Chen
2. 1. Cancer Biology
   2. Computational and Systems Biology

   Comprehensive characterization of tumor microenvironment in colorectal cancer via molecular analysis

   Xiangkun Wu, Hong Yan ... Li Liang

   Integrated molecular analysis demonstrated that colorectal cancer can be classified into four molecular subtypes (proliferative, immunomodulatory, immunosuppressed, and immune-excluded subtypes), providing valuable insight into the intricate relationship between tumor microenvironment heterogeneity and various clinical phenotypes.
3. 1. Cancer Biology

   Defining function of wild-type and three patient specific TP53 mutations in a zebrafish model of embryonal rhabdomyosarcoma

   Jiangfei Chen, Kunal Baxi ... Myron S Ignatius
4. 1. Cancer Biology

   Proteomic characteristics reveal the signatures and the risks of T1 colorectal cancer metastasis to lymph nodes

   Aojia Zhuang, Aobo Zhuang ... Chen Ding

   Based on the proteomics results, T1 CRC LNM prediction models were built using machine learning, the functional differences and biomarkers between LNM-negative and LNM-positive patients were revealed.
5. 1. Cancer Biology

   The CD73 immune checkpoint promotes tumor cell metabolic fitness

   David Allard, Isabelle Cousineau ... John Stagg
6. 1. Cancer Biology
   2. Genetics and Genomics

   MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer

   Changyu Zhu, Yadira M Soto-Feliciano ... Scott W Lowe
7. 1. Cancer Biology
   2. Computational and Systems Biology

   GENIUS: GEnome traNsformatIon and spatial representation of mUltiomicS data

   Mateo Sokač, Lars Dyrskjøt ... Nicolai J Birkbak
8. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis

   Juan J Apiz Saab, Lindsey N Dzierozynski ... Alexander Muir
9. 1. Cancer Biology
   2. Computational and Systems Biology

   Predictive nonlinear modeling of malignant myelopoiesis and tyrosine kinase inhibitor therapy

   Jonathan Rodriguez, Abdon Iniguez ... Richard A Van Etten

   A physiological mathematical model of chronic myeloid leukemia, validated by experiments in transgenic mice and clinical data, identifies mechanisms underlying the response to tyrosine kinase inhibitor therapy, predicts biomarkers of primary resistance, and suggests new strategies to improve treatment outcomes.
10. 1. Cancer Biology
    2. Evolutionary Biology

    Cancers adapt to their mutational load by buffering protein misfolding stress

    Susanne Tilk, Judith Frydman ... Dmitri Petrov