Cancer Biology

Latest articles

1. 1. Cancer Biology
   2. Developmental Biology

   Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects

   Maja Solman et al.

   The transcriptomes of hematopoietic stem and progenitor cells of human juvenile myelomonocytic leukemia patients and a zebrafish model for Noonan syndrome reveal a common inflammatory response, which may have a causal role in associated myeloproliferative neoplasm.
2. 1. Cancer Biology
   2. Computational and Systems Biology

   Regulation of protein complex partners as a compensatory mechanism in aneuploid tumors

   Gökçe Senger et al.
3. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells

   David J Hosfield et al.
4. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells

   Yanchun Zhang et al.

   Beyond its well-accepted function in metastasis, non-receptor tyrosine kinase FER also controls ovarian tumor cell proliferation through FER-IRS4-AKT signaling axis, making itself as a promising druggable target for the disease.
5. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor targeting therapies

   Justin H Hwang et al.
6. 1. Cancer Biology

   Detection of malignant peripheral nerve sheath tumors in patients with neurofibromatosis using aneuploidy and mutation identification in plasma

   Austin K Mattox et al.

   Detection of aneuploidy and/or mutations in ctDNA may represent a promising approach to detecting patients with MPNST.
7. 1. Cancer Biology

   Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme

   Guillaume Jacquemin et al.

   Studies of organoid morphogenesis, combined with proteomics and molecular profiling, identify the THBS1-YAP axis as a signalling mechanism that mediates paracrine communication between tumour cells and their wildtype epithelial neighbours.
8. 1. Cancer Biology
   2. Genetics and Genomics

   Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs

   Antonio Cuevas-Navarro et al.

   Biochemical and genetic analysis of the functional relationship between RIT1 and its regulatory protein, LZTR1, across various model organisms helps define the substrate specificity of LZTR1 for RAS GTPases.
9. 1. Cancer Biology
   2. Cell Biology

   Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice

   Edward Fielder et al.
10. 1. Cancer Biology
    2. Immunology and Inflammation

    The oncoprotein BCL6 enables solid tumor cells to evade genotoxic stress

    Yanan Liu et al.

    Oncoprotein BCL6 confers tumor adaptive resistance to genotoxic stress through the IFN-BCL6-PTEN axis in solid tumors and presents a promising combinational target for chemo-sensitization.