Cancer Biology

Latest articles

1. 1. Cancer Biology

   Breast Cancer: Slowing the growth of drug-resistant tumors

   Yingyi Zhang, Qianying Lu

   Using drugs that inhibit enzymes called CDK4/6 and CDK2 extends the G1 phase of the cell cycle and helps to slow the growth of drug-resistant breast cancer.
2. 1. Cell Biology
   2. Cancer Biology

   GMCL1 Controls 53BP1 Stability and Modulates Taxane Sensitivity

   Yuki Kito, Tania J González-Robles ... Michele Pagano
3. 1. Cancer Biology

   Multi-gradient permutation survival analysis identifies mitosis and immune signatures steadily associated with cancer patient prognosis

   Xinlei Cai, Yi Ye ... Hongbin Ji

   Genes steadily associated with prognosis define conserved mitotic and immune programs that robustly predict cancer patient survival and therapeutic resistance across tumor types.
4. 1. Cancer Biology

   Transcriptional subtypes on immune microenvironment and predicting postoperative recurrence and metastasis in human pheochromocytoma and paraganglioma

   Yang Liu, Xu Yan ... Lingyu Li

   Distinct transcriptional subtypes in PPGLs link molecular programs with immune context, providing biomarkers for recurrence risk and therapeutic targeting.
5. 1. Cancer Biology

   Endoscopic liquid biopsies of gastric fluid in a large human patient cohort reveal DNA content as a candidate tumor biomarker in gastric cancer

   Francine C Cadoná, Thais F Bartelli ... Emmanuel Dias-Neto

   Elevated gfDNA supports gastric cancer diagnosis and may guide management when combined with tissue biopsies, and in established cancer, higher gfDNA may predict better outcomes, potentially indicating immune-cell infiltration.
6. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Degradation of LMO2 in T cell leukaemia results in collateral breakdown of transcription complex partners and causes LMO2-dependent apoptosis

   Naphannop Sereesongsaeng, Carole Bataille ... Terence Rabbitts

   Antibody surrogate degraders of LMO2 indicate that transcription complexes are susceptible to drug discovery and are therefore druggable.
7. 1. Cancer Biology

   Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics

   Inbal Avraham-Davidi, Simon Mages ... Aviv Regev

   An integrative analysis of scRNA-seq and spatial transcriptomics provides complementary views into the biology of pre-clinical colorectal cancer models in mice with possible applications to the human system.
8. 1. Genetics and Genomics
   2. Cancer Biology

   Early Diagnosis and Prognostic Prediction of Colorectal Cancer through Plasma Methylation Regions

   Lingqin Zhu, Lang Yang ... Jianqiu Sheng
9. 1. Cancer Biology

   Mitochondrial Protein Carboxyl-Terminal Alanine-Threonine Tailing Promotes Glioblastoma Tumor Growth by Regulating Mitochondrial Function

   Bei Zhang, Ting Cai ... Zhihao Wu
10. 1. Genetics and Genomics
    2. Cancer Biology

    Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma

    Olivia G Waltner, April A Apfelbaum ... Scott N Furlan