Cancer Biology

Latest articles

1. 1. Cancer Biology
   2. Immunology and Inflammation

   NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte

   SM Nashir Udden et al.

   NOD-like receptor NLRP12 is a critical regulator of hepatocyte proliferation and its activation could be therapeutically used to suppress hepatocellular carcinoma.
2. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Novel RNA and DNA strand exchange activity of the PALB2 DNA Binding Domain and its critical role for DNA repair in cells

   Jaigeeth Deveryshetty et al.
3. 1. Cancer Biology
   2. Immunology and Inflammation

   CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors

   Andrea Walens et al.

   CCL5-dependent macrophage recruitment drives breast cancer recurrence through collagen deposition in residual tumors.
4. 1. Cancer Biology
   2. Genetics and Genomics

   Single-cell lineage tracing by endogenous mutations enriched in transposase accessible mitochondrial DNA

   Jin Xu et al.

   Epigenome and Mitochondrial Barcode of Lineage from Endogenous Mutations (EMBLEM) enable tracking cell lineage in combination with chromatin profile in ATAC-seq data.
5. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

   Mark R Sullivan et al.
6. 1. Cancer Biology
   2. Genetics and Genomics

   Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma

   Jianing Xu et al.

   A distinct class of kidney tumors is characterized not by patterns of somatic mutations, but by a distinct metabolism.
7. 1. Cancer Biology
   2. Cell Biology

   Opto-magnetic capture of individual cells based on visual phenotypes

   Loïc Binan et al.
8. 1. Cancer Biology

   Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization

   Harihar Basnet et al.

   Development and application of highly sensitive in situ transcriptomics method, Flura-seq, in identifying dynamic organ-specific transcriptomes in early stage breast cancer metastasis have been described.
9. 1. Cancer Biology
   2. Human Biology and Medicine

   Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition

   Andrew L Hong et al.

   Faithful models of RMC require SMARCB1 loss for survival, and genetic and small-molecule screens identify inhibition of the ubiquitin-proteasome system (UPS) as a potential therapeutic approach for SMARCB1 deficient cancers.
10. 1. Cancer Biology
    2. Developmental Biology

    A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion

    Katarina Valoskova et al.

    T antigen glycosylation, which marks metastatic cancer cells, is modulated on a small set of proteins by a conserved multipass transmembrane protein to allow tissue invasion by Drosophila macrophages.