Cancer Biology

Latest articles

1. 1. Cell Biology
   2. Cancer Biology

   Transferred mitochondria accumulate reactive oxygen species, promoting proliferation

   Chelsea U Kidwell, Joseph R Casalini ... Minna Roh-Johnson

   Transferred mitochondria do not always regulate cell behavior by simply restoring mitochondrial function, but rather, transferred mitochondria are dysfunctional, initiating downstream signaling and proliferation in response to reactive oxygen species.
2. 1. Cancer Biology
   2. Computational and Systems Biology

   Interrogating the precancerous evolution of pathway dysfunction in lung squamous cell carcinoma using XTABLE

   Matthew Roberts, Julia Ogden ... Carlos Lopez-Garcia

   XTABLE is the first easy-to-use bioinformatic solution that has been conceived and designed solely to interrogate the transcriptomes of premalignant stages of lung squamous cell carcinoma (LUSC) and enhance the development of LUSC prevention and detection strategies.
3. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Multi-targeted therapy resistance via drug-induced secretome fucosylation

   Mark Borris D Aldonza, Junghwa Cha ... Yoosik Kim
4. 1. Cancer Biology
   2. Microbiology and Infectious Disease

   Evidence for virus-mediated oncogenesis in bladder cancers arising in solid organ transplant recipients

   Gabriel J Starrett, Kelly Yu ... Eric A Engels
5. 1. Cancer Biology
   2. Medicine

   A survey of open questions in adaptive therapy: Bridging mathematics and clinical translation

   Jeffrey West, Fred Adler ... Alexander RA Anderson

   Open questions of cancer adaptive therapy are discussed through the lens of mathematical modeling, categorized into three sections, (1) integrating appropriate components into mathematical models, (2) dosing protocol design and validation, and (3) challenges and opportunities in clinical translation.
6. 1. Cancer Biology
   2. Cell Biology

   Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion

   Elena Tomas Bort, Megan Daisy Joseph ... Richard Philip Grose
7. 1. Cancer Biology

   Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins

   Kexin Li, Qingji Huo ... Hiroki Yokota

   The anti-tumor action of engineered mesenchymal stem cells highlights the double-edged role of oncoproteins in osteosarcoma, and suggests the possibility of developing a novel strategy for protein-based cancer therapy.
8. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Mitochondrial redox adaptations enable alternative aspartate synthesis in SDH-deficient cells

   Madeleine L Hart, Evan Quon ... Lucas B Sullivan

   SDH-null cancer cells decrease mitochondrial complex I to drive rewired aspartate synthesis through reductive carboxylation and pyruvate carboxylase, supporting cell proliferation and tumor growth.
9. 1. Cancer Biology

   Kindlin-1 regulates IL-6 secretion and modulates the immune environment in breast cancer models

   Emily R Webb, Georgia L Dodd ... Valerie G Brunton

   New roles in anti-tumour immunity for the adhesion protein Kindlin-1 via regulation of cytokine secretion and T cell regulation.
10. 1. Stem Cells and Regenerative Medicine
    2. Cancer Biology

    Mesenchymal stem cell suppresses the efficacy of CAR-T toward killing lymphoma cells by modulating the microenvironment through stanniocalcin-1

    Rui Zhang, Qingxi Liu ... Wenjian Ma

    The stanniocalcin-1-dependent immunosuppressive roles of mesenchymal stem cell on chimeric antigen receptor modified T cell therapy.