Cancer Biology

Cancer Biology

eLife publishes research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cancer Biology
    2. Cell Biology

    Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression

    Qiangqiang Liu et al.
    SIAH2 and OTUD5 orchestrate DBC1 ubiquitination and degradation under hypoxic conditions.
    1. Cancer Biology
    2. Genetics and Genomics

    Unsupervised detection of fragment length signatures of circulating tumor DNA using non-negative matrix factorization

    Gabriel Renaud et al.
    Non-negative Matrix Factorization is a powerful strategy for unsupervised analysis of cell-free DNA that enables simultaneous estimation of the blood tumor fraction and the fragment length distribution of circulating tumor DNA.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Polysome-CAGE of TCL1-driven chronic lymphocytic leukemia revealed multiple N-terminally altered epigenetic regulators and a translation stress signature

    Ariel Ogran et al.
    Examination of the changes in the transcription start site selection in TCL1-driven chronic lymphocytic leukemia and their impact on mRNA translation revealed a marked elevation of intra-genic cryptic promoters, which are predicted to generate multiple N-terminally truncated or modified proteins.
    1. Cancer Biology

    Robust and Efficient Assessment of Potency (REAP) as a quantitative tool for dose-response curve estimation

    Shouhao Zhou et al.
    A novel approach together with a user-friendly web-based analytic tool, coined 'REAP', was proposed to improve the quantitative assessment of dose-response relationship and drug potency.
    1. Cancer Biology

    Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery

    Laura M Sipe et al.
    Bariatric surgery reversed obesity-exacerbated tumor burden and increased efficacy of anti-PD-L1 immunotherapy.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context

    Samuel A Kerk et al.
    Inhibition of GOT2 drives growth inhibitory reductive stress that can be rescued by electron acceptors in vitro, whereas GOT2 inhibition in endogenous or transplanted tumor models is tolerated without consequence, highlighting the importance of context when studying tumor metabolism.
    1. Cancer Biology
    2. Cell Biology

    The integrated stress response remodels the microtubule-organizing center to clear unfolded proteins following proteotoxic stress

    Brian Hurwitz et al.
    In response to proteotoxic stress, squamous cell carcinoma cells hijack the integrated stress response to promote recovery by bolstering protection of microtubule dynamics.
    1. Cancer Biology

    Differentiated glioma cell-derived fibromodulin activates integrin-dependent Notch signaling in endothelial cells to promote tumor angiogenesis and growth

    Shreoshi Sengupta et al.
    Comprehensive proteomic investigation and functional studies unravel an essential role of differentiated glioma cell-secreted fibromodulin (FMOD) in regulating glioblastoma tumor growth by inducing angiogenesis by activating integrin-dependent Notch signaling in endothelial cells, highlighting FMOD as a potential therapeutic target.

Senior editors

  1. Wafik S El-Deiry
    Brown University, United States
  2. Erica Golemis
    Fox Chase Cancer Center, United States
  3. Richard M White
    Memorial Sloan Kettering Cancer Center, United States
  4. See more editors