Cancer Biology

Latest articles

1. 1. Cancer Biology

   Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells

   Bente Benedict et al.
2. 1. Cancer Biology

   CD95/Fas ligand mRNA is toxic to cells

   Will Putzbach et al.

   The mRNA of the apoptosis inducing death ligand CD95L/FasL kills cancer cells through RNAi after conversion into small RNAs that are loaded into the RNA-induced Silencing Complex.
3. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   UBE2G1 governs the destruction of cereblon neomorphic substrates

   Gang Lu et al.

   Cereblon-based small-molecule degraders rely on the sequential action of ubiquitin-conjugating enzymes UBE2G1 and UBE2D3 to assemble K48-linked polyubiquitin chains on cereblon neomorphic substrates, resulting in their proteasomal degradation.
4. 1. Cancer Biology

   Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota

   Kathryn Eaton et al.

   Editors' Summary: This Replication Study has reproduced some parts of the original paper but it also contains results that are not consistent with other parts of the original paper.
5. 1. Cancer Biology
   2. Human Biology and Medicine

   Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death

   Haley Hieronymus et al.

   The percentage of a tumor’s genome with alterations in copy number is correlated with increased mortality across a range of tumor types and can be measured using a clinically approved sequencing assay.
6. 1. Cancer Biology
   2. Cell Biology

   Aurora kinase A localises to mitochondria to control organelle dynamics and energy production

   Giulia Bertolin et al.

   AurkA is imported into mitochondria at interphase, and it induces organelle elongation and enhances ATP production when over-expressed.
7. 1. Cancer Biology
   2. Immunology and Inflammation

   Topography of cancer-associated immune cells in human solid tumors

   Jakob Nikolas Kather et al.

   Spatial patterns of lymphoid and myeloid cells in human solid tumors differ between cancer types, yielding a new classification of anti-tumor host response.
8. 1. Cancer Biology

   tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish

   Myron S Ignatius et al.

   Syngeneic tp53-null zebrafish develop a wide range of tumors that engraft into recipient animals with loss of Tp53 leading to increased metastasis in embryonal rhabdomyosarcoma (ERMS), likely accounting for increased aggression in TP53-inactivated human ERMS.
9. 1. Cancer Biology
   2. Stem Cells and Regenerative Medicine

   HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties

   Ethan V Abel et al.

   HNF1A, a risk factor gene for pancreatic ductal adenocarcinoma, is critical to maintaining pancreatic cancer stem cell properties through regulating POU5F1 (OCT4) expression, providing a novel role for HNF1A in maintenance of the disease.
10. 1. Cancer Biology
    2. Cell Biology

    An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer

    Ji Li et al.

    Splicing by QKI and RBFOX1 regulates the function of the actin-binding protein FLNB by creating an isoform frequently observed in human cancers that dictates tumor cell plasticity.