Cancer Biology

Cancer Biology

eLife publishes research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cancer Biology
    2. Developmental Biology

    Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects

    Maja Solman et al.
    The transcriptomes of hematopoietic stem and progenitor cells of human juvenile myelomonocytic leukemia patients and a zebrafish model for Noonan syndrome reveal a common inflammatory response, which may have a causal role in associated myeloproliferative neoplasm.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells

    Yanchun Zhang et al.
    Beyond its well-accepted function in metastasis, non-receptor tyrosine kinase FER also controls ovarian tumor cell proliferation through FER-IRS4-AKT signaling axis, making itself as a promising druggable target for the disease.
    1. Cancer Biology

    Detection of malignant peripheral nerve sheath tumors in patients with neurofibromatosis using aneuploidy and mutation identification in plasma

    Austin K Mattox et al.
    Detection of aneuploidy and/or mutations in ctDNA may represent a promising approach to detecting patients with MPNST.
    1. Cancer Biology

    Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme

    Guillaume Jacquemin et al.
    Studies of organoid morphogenesis, combined with proteomics and molecular profiling, identify the THBS1-YAP axis as a signalling mechanism that mediates paracrine communication between tumour cells and their wildtype epithelial neighbours.
    1. Cancer Biology
    2. Genetics and Genomics

    Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs

    Antonio Cuevas-Navarro et al.
    Biochemical and genetic analysis of the functional relationship between RIT1 and its regulatory protein, LZTR1, across various model organisms helps define the substrate specificity of LZTR1 for RAS GTPases.
    1. Cancer Biology
    2. Immunology and Inflammation

    The oncoprotein BCL6 enables solid tumor cells to evade genotoxic stress

    Yanan Liu et al.
    Oncoprotein BCL6 confers tumor adaptive resistance to genotoxic stress through the IFN-BCL6-PTEN axis in solid tumors and presents a promising combinational target for chemo-sensitization.

Senior editors

  1. Utpal Banerjee
    University of California, Los Angeles, United States
  2. Wafik S El-Deiry
    Brown University, United States
  3. Erica Golemis
    Fox Chase Cancer Center, United States
  4. See more editors