Cancer Biology

Latest articles

1. 1. Cancer Biology
   2. Cell Biology

   Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation

   Maxim I Maron et al.

   Biochemical, transcriptomic, and proteomic analyses reveal that protein arginine methyltransferases post-transcriptionally regulate intron detention—introns that persist in nuclear polyadenylated RNA—through methylation of RNA splicing and processing factors.
2. 1. Cancer Biology
   2. Ecology

   Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe

   Daniel Garcia-Souto et al.

   Genome sequencing analysis dissects the origins and evolution of cancer transmission between clam species in the Seas of Southern Europe.
3. 1. Cancer Biology
   2. Cell Biology

   Chromatin topology defines estradiol-primed progesterone receptor and PAX2 binding in endometrial cancer cells

   Alejandro La Greca et al.
4. 1. Cancer Biology
   2. Genetics and Genomics

   Crosstalk with keratinocytes causes GNAQ oncogene specificity in melanoma

   Oscar Urtatiz et al.

   G alpha q/11 signaling can either promote or inhibit melanocyte growth through a reversible switch that is controlled by the microenvironment and that shapes the mutational diversity of melanoma subtypes.
5. 1. Cancer Biology
   2. Genetics and Genomics

   Functional CDKN2A assay identifies frequent deleterious alleles misclassified as variants of uncertain significance

   Hirokazu Kimura et al.
6. 1. Cancer Biology
   2. Computational and Systems Biology

   Quantitative analysis of tumour spheroid structure

   Alexander P Browning et al.

   A novel quantitative framework to analyse the inner structure of tumour spheroids in terms of the mechanisms that underly growth.
7. 1. Cancer Biology

   Hyaluronic acid fuels pancreatic cancer cell growth

   Peter K Kim et al.

   Pancreatic cancers can utilize hyaluronic acid, an abundant extracellular matrix component in the tumor microenvironment, to fuel cancer cell metabolism and growth.
8. 1. Cancer Biology
   2. Cell Biology

   Single-cell transcriptome analysis identifies a unique tumor cell type producing multiple hormones in ectopic ACTH and CRH secreting pheochromocytoma

   Xuebin Zhang et al.

   A novel multi-hormones secreting chromaffin-like cell type was identified using single-cell RNA sequencing, suggesting the molecular mechanism of ectopic ACTH and CRH pheochromocytoma associated with Cushing’s syndrome.
9. 1. Cancer Biology
   2. Cell Biology

   Heat shock factor 1 (HSF1) cooperates with estrogen receptor α (ERα) in the regulation of estrogen action in breast cancer cells

   Natalia Vydra et al.

   Heat shock factor 1 is involved in estrogen-induced chromatin remodeling in estrogen receptor-positive breast cancer cells.
10. 1. Cancer Biology

    Extent, impact, and mitigation of batch effects in tumor biomarker studies using tissue microarrays

    Konrad H Stopsack et al.