Cancer Biology

Latest articles

1. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation

   Lizhi He et al.

   YAP and TAZ, the ultimate targets of the Hippo signaling pathway, are transcriptional co-activators of AP-1 proteins and STAT3 through which they are important for breast cellular transformation.
2. 1. Cancer Biology
   2. Medicine

   Cancer Immunotherapy: A promising platform for predicting toxicity

   Maria Ochoa de Olza

   Organ-on-chip approaches could help researchers to better predict the toxicity of cancer immunotherapy drugs.
3. 1. Cancer Biology
   2. Cell Biology

   Fine-tuned repression of Drp1 driven mitochondrial fission primes a 'stem/progenitor-like state' to support neoplastic transformation

   Brian Spurlock et al.
4. 1. Cancer Biology
   2. Neuroscience

   Stimulation of hypothalamic oxytocin neurons suppresses colorectal cancer progression in mice

   Susu Pan et al.
5. 1. Cancer Biology
   2. Cell Biology

   Identification of abscission checkpoint bodies as structures that regulate ESCRT factors to control abscission timing

   Lauren K Williams et al.

   Cytoplasmic bodies sequester important abscission machinery to delay completion of cytokinesis in response to mitotic errors.
6. 1. Cancer Biology

   Lipid droplets and ferritin heavy chain: a devilish liaison in human cancer cell radioresistance

   Luca Tirinato et al.
7. 1. Cancer Biology
   2. Computational and Systems Biology

   Integrated evaluation of telomerase activation and telomere maintenance across cancer cell lines

   Kevin Hu et al.
8. 1. Cancer Biology

   A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth

   Joanna L Gillis et al.

   A positive feedback loop between the androgen receptor and a key pentose phosphate pathway enzyme, 6PGD, in prostate cancer promotes tumour cell proliferation, survival and intracellular redox control.
9. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis

   Satoshi Takahashi et al.

   Interaction of the MLL and HBO1 complexes is a key nexus for leukemic transformation that can serve as a therapeutic target.
10. 1. Cancer Biology
    2. Medicine

    Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies

    S Jordan Kerns et al.

    Novel human models of the lung and intestine are described and validated as preclinical in vitro tools for predictive profiling of T-cell-bispecific antibodies with expected on-target off-tumor risk.