Cancer Biology

Latest articles

1. 1. Cell Biology
   2. Cancer Biology

   Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP Signaling

   Rachel Nakagawa, Andrew Beardsley ... Andrei Goga
2. 1. Cancer Biology
   2. Cell Biology

   Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications

   Ida Marie Boisen, Nadia Krarup Knudsen ... Martin Blomberg Jensen

   Testicular microcalcifications arise secondary to local alterations in mineral homeostasis, which in combination with impaired Sertoli cell function and reduced levels of mineralization inhibitors facilitate deposition of hydroxyapatite.
3. 1. Cancer Biology

   Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab resistant HER2 positive breast cancer

   Yijia Hua, Ningjun Duan ... Yongmei Yin
4. 1. Cancer Biology

   Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis

   Patrick B Jonker, Mumina Sadullozoda ... Alexander Muir
5. 1. Cell Biology
   2. Cancer Biology

   A single cysteine residue in vimentin regulates long non-coding RNA XIST to suppress epithelial-mesenchymal transition and stemness in breast cancer

   Saima Usman, W Andrew Yeudall ... Ahmad Waseem
6. 1. Cancer Biology

   TAK1-mediated phosphorylation of PLCE1 represses PIP2 hydrolysis to impede esophageal squamous cancer metastasis

   Qianqian Ju, Wenjing Sheng ... Cheng Sun

   TAK1 plays a negative role in esophageal squamous cancer cell metastasis, which depends on the TAK1-induced phosphorylation of PLCE1 at S1060 and subsequent inhibition of PIP2 hydrolysis.
7. 1. Cell Biology
   2. Cancer Biology

   RUNX2 Isoform II Protects Cancer Cells from Ferroptosis and Apoptosis by Promoting PRDX2 Expression in Oral Squamous Cell Carcinoma

   Junjun Huang, Rong Jia, Jihua Guo
8. 1. Cell Biology
   2. Cancer Biology

   DuoHexaBody-CD37 induces direct cytotoxic signaling in diffuse large B-cell lymphoma

   Simar Pal Singh, Michelle D van den Beukel ... Annemiek B van Spriel
9. 1. Cancer Biology
   2. Cell Biology

   Breast Cancer: How cell crowding causes cancer cells to spread

   Rui Hua, Jean X Jiang

   Cell crowding causes high-grade breast cancer cells to become more invasive by activating a molecular switch that causes the cells to shrink and spread.
10. 1. Cancer Biology
    2. Cell Biology

    Cell crowding activates pro-invasive mechanotransduction pathway in high-grade DCIS via TRPV4 inhibition and cell volume reduction

    Xiangning Bu, Nathanael Ashby ... Inhee Chung

    Cell crowding drives a pro-invasive mechanotransduction pathway in high-grade DCIS, inducing TRPV4 inhibition, calcium and cell volume reduction, and increased invasion, with compensatory plasma-membrane TRPV4 relocation indicating pathway activation.