Cancer Biology

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Cancer Biology

   The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma

   Ariunaa Bayanjargal, Cenny Taslim ... Emily R Theisen
2. 1. Cell Biology
   2. Cancer Biology

   Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics

   David Papadopoli, Ranveer Palia ... Ivan Topisirovic
3. 1. Immunology and Inflammation
   2. Cancer Biology

   The 1000+ mouse project: large–scale spatiotemporal parametrization and modeling of preclinical cancer immunotherapies

   Adam L Kenet, Sooraj Achar ... Grégoire Altan-Bonnet
4. 1. Cancer Biology

   A mediterranean-mimicking diet harnesses gut microbiota–derived 3-IAA to rejuvenate T cell

   Xin Yu, Wenge Li ... Qi Wu
5. 1. Chromosomes and Gene Expression
   2. Cancer Biology

   Depletion of rRNA Methyltranferase METTL5 Enhances Anti-Tumor Immune Response via Neoantigen Generated from Cryptic Translation

   Yangyi Zhang, Xiaoyan Shi ... Hao Chen
6. 1. Computational and Systems Biology
   2. Cancer Biology

   End-to-end proteogenomics for discovery of cryptic and non-canonical cancer proteoforms using long-read transcriptomics and multi-dimensional proteomics

   Katarzyna Kulej, Asher Preska Steinberg ... Alex Kentsis
7. 1. Cancer Biology
   2. Computational and Systems Biology

   Single-cell atlas of AML reveals age-related gene regulatory networks in t(8;21) AML

   Jessica Whittle, Stefan Meyer ... Mudassar Iqbal

   A comprehensive single-cell atlas of AML uncovers regulatory networks and age-dependent molecular differences to advance the understanding of disease mechanisms and enable subtype-specific therapeutic strategies.
8. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1⁺ TAMs

   Fangyuan Dong, Shan Zhang ... Shu-Heng Jiang

   Drug repurposing analyses show that citalopram exerts anti-tumor effects by targeting C5aR1 on tumor-associated macrophages to enhance phagocytosis and CD8⁺ T cell immunity.
9. 1. Cancer Biology

   Repression of PRMT activities sensitize human homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment

   Youyou Zhang, Mu Xu ... Xiaowen Hu

   Inhibiting PRMT1 and PRMT5 renders HR-proficient ovarian and breast cancers highly vulnerable to PARP inhibition by suppressing BRCAness and amplifying DNA-damage-driven innate immune signaling.
10. 1. Cancer Biology
    2. Cell Biology

    Mitochondrial protein carboxyl-terminal alanine-threonine tailing promotes human glioblastoma growth by regulating mitochondrial function

    Bei Zhang, Ting Cai ... Zhihao Wu

    The carboxyl-terminal alanine-threonine-tailed protein ATP5α helps glioblastoma mitochondria maintain a high membrane potential and keep the permeability transition pore closed, thereby promoting tumor growth and increasing resistance to apoptosis.