Cancer Biology

Latest articles

1. 1. Cancer Biology
   2. Cell Biology

   Defective apoptotic cell contractility provokes sterile inflammation leading to liver damage and tumour suppression

   Linda Julian et al.
2. 1. Cancer Biology
   2. Developmental Biology

   An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma

   Rediet Zewdu et al.
3. 1. Cancer Biology
   2. Cell Biology

   The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

   Margaret E Torrence et al.

   ATF4 is a metabolic effector of mTORC1 signaling, co-opted to induce gene targets involved in amino acid synthesis, uptake, and tRNA charging, contributing to mTORC1-driven protein and glutathione synthesis.
4. 1. Cancer Biology
   2. Evolutionary Biology

   Pervasive duplication of tumor suppressors in Afrotherians during the evolution of large bodies and reduced cancer risk

   Juan M Vazquez, Vincent J Lynch

   Duplication of tumor suppressor genes contributed to the evolution of large, long-lived elephants.
5. 1. Cancer Biology

   Dissecting phenotypic transitions in metastatic disease via photoconversion-based isolation

   Yogev Sela et al.

   A photoconversion-based isolation technique enables systematic investigation of spatially distinct small metastases (microcolonies) versus large lesions (macrometastases).
6. 1. Cancer Biology
   2. Computational and Systems Biology

   shinyDepMap, a tool to identify targetable cancer genes and their functional connections from Cancer Dependency Map data

   Kenichi Shimada et al.

   shinyDepMap helps users explore the essentiality, selectivity, and function of the genes across hundreds of cancer cell lines and identify cancer drug targets.
7. 1. Cancer Biology
   2. Neuroscience

   Estrogen receptor alpha in the brain mediates tamoxifen-induced changes in physiology in mice

   Zhi Zhang et al.

   Estrogen receptor alpha in the hypothalamus is required for the effects of chronic tamoxifen treament on gene expression, thermoregulation, bone, and movement in mice.
8. 1. Cancer Biology
   2. Genetics and Genomics

   Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells

   Iris E Glykofridis et al.

   Knocking out Folliculin (FLCN) in human renal epithelial cells activates STAT1/2-mediated gene expression, independent of interferon, uncovering a tissue-specific process potentially relevant in the cancer syndrome Birt-Hogg-Dubé (BHD).
9. 1. Cancer Biology
   2. Immunology and Inflammation

   Human primed ILCPs support endothelial activation through NF-κB signaling

   Giulia Vanoni et al.

   Circulating human primed innate lymphoid cell precursors have the potential to functionally induce adhesion molecules' expression in endothelial cells and possibly support the immune cells' infiltration into the tumor site.
10. 1. Cancer Biology

    Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

    Sumiko Takao et al.

    Definition of leukemia gene expression mechanisms reveals general principles of cancer gene control and offers a pharmacologic strategy for its therapeutic reprogramming.