Cancer Biology

Latest articles

1. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B

   Pieter A Roelofs et al.
2. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones

   Jay F Sarthy et al.

   Deposition of mutant oncohistones by alternative nucleosome assembly pathways results in dramatic local differences in histone methylation in pediatric diffuse midline gliomas.
3. 1. Cancer Biology
   2. Developmental Biology

   SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells

   Erik Oliemuller et al.

   SOX11+ breast tumours display reactivated embryonic developmental signalling and organogenetic features and are at elevated risk of developing metastases, so may benefit from more aggressive therapies.
4. 1. Cancer Biology
   2. Cell Biology

   MAPK activity dynamics regulate non-cell autonomous effects of oncogene expression

   Timothy J Aikin et al.

   The temporal patterns of MAPK activity differentially regulate cell autonomous and non-cell autonomous effects of oncogene expression.
5. 1. Cancer Biology
   2. Cell Biology

   Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling

   Yingqi Liu et al.

   PRMT7-mediated SHANK2 methylation regulates breast cancer metastasis by activating endosomal FAK signals, and may provide potential clues for tumour metastasis treatment strategies.
6. 1. Cancer Biology
   2. Cell Biology

   IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation

   Li Pan et al.
7. 1. Cancer Biology
   2. Cell Biology

   PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response

   Chiho Kim et al.

   Identification of PARP1 trapping as the major contributor of PARP1 inhibitor-induced innate immune response.
8. 1. Cancer Biology
   2. Stem Cells and Regenerative Medicine

   A single-cell atlas of the mouse and human prostate reveals heterogeneity and conservation of epithelial progenitors

   Laura Crowley et al.
9. 1. Cancer Biology
   2. Physics of Living Systems

   Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy

   Xin Cui et al.

   A biomimetic and patient-specific Glioblastoma-on-a-Chip microphysiological system provides an avenue for personalized screening of PD-1 immunotherapy and novel combinational therapies that maximize therapeutic outcomes in Glioblastoma patients.
10. 1. Cancer Biology

    Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer

    Patricia L Theard et al.

    Combined EGFR and SOS1 inhibition synergize to inhibit NSCLC spheroid growth.