Cancer Biology

Latest articles

1. 1. Cancer Biology
   2. Genetics and Genomics

   Mismatch repair-signature mutations activate gene enhancers across human colorectal cancer epigenomes

   Stevephen Hung et al.

   Non-coding mutations in microsatellite-instable (MSI) colorectal tumors are prevalent and activate cancer-specific enhancers, thereby disrupting gene expression control.
2. 1. Cancer Biology
   2. Human Biology and Medicine

   FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells

   Nathalie Javidi-Sharifi et al.

   Inhibition of FGF2-FGFR1 signaling in bone marrow stroma attenuates secretion of FGF2-laden exosomes and subsequent protection of leukemia cells.
3. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Cellular acidosis triggers human MondoA transcriptional activity by driving mitochondrial ATP production

   Blake R Wilde et al.

   The MondoA transcription factor localizes to the outer mitochondrial membrane where it coordinates an adaptive transcriptional response to elevated cellular energy represented by high cytoplasmic glucose and high mitochondrial ATP.
4. 1. Cancer Biology
   2. Cell Biology

   Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation

   Cong-Hui Yao et al.

   In addition to increasing glycolysis, some proliferating cells exhibiting the Warburg effect also increase oxidative phosphorylation through mitochondrial fusion.
5. 1. Cancer Biology

   Different genetic mechanisms mediate spontaneous versus UVR-induced malignant melanoma

   Blake Ferguson et al.
6. 1. Cancer Biology

   GREB1 amplifies androgen receptor output in human prostate cancer and contributes to antiandrogen resistance

   Eugine Lee et al.

   Prostate cancer cells maintain heterogeneous androgen receptor transcriptional activity through upregulation of AR-regulated coactivator GREB1, and cells with high activity rapidly develop resistance to antiandrogen therapy in a GREB1-dependent manner.
7. 1. Cancer Biology

   The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells

   Sean W Fanning et al.

   Bazedoxifene's SERD activities enable it to resist the impact of activating ESR1 mutations in breast cancer.
8. 1. Cancer Biology

   Breast Cancer: Targeting mutant estrogen receptors

   Suzanne E Wardell et al.

   A drug used in hormone replacement therapy can target estrogen receptors that have become resistant to breast cancer treatments.
9. 1. Cancer Biology

   miR-34a is a microRNA safeguard for Citrobacter-induced inflammatory colon oncogenesis

   Lihua Wang et al.

   miR-34a prevents inflammation-induced colonic regeneration from oncogenesis by simultaneously targeting processes in both immune and epithelial cells, including T helper 17 cell differentiation, recruitment, and IL-17 induced epithelial proliferation.
10. 1. Cancer Biology

    FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer

    Soledad A Camolotto et al.

    Lineage specifiers FoxA1 and FoxA2 control lung cancer growth and identity by activating gastric differentiation and suppressing squamous cell carcinoma transdifferentiation.