Cancer Biology

Cancer Biology

eLife reviews research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Immunology and Inflammation
    2. Cancer Biology

    The 1000+ mouse project: large–scale spatiotemporal parametrization and modeling of preclinical cancer immunotherapies

    Adam L Kenet, Sooraj Achar ... Grégoire Altan-Bonnet
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Depletion of rRNA Methyltranferase METTL5 Enhances Anti-Tumor Immune Response via Neoantigen Generated from Cryptic Translation

    Yangyi Zhang, Xiaoyan Shi ... Hao Chen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cancer Biology

    A mediterranean-mimicking diet harnesses gut microbiota–derived 3-IAA to rejuvenate T cell

    Xin Yu, Wenge Li ... Qi Wu
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Solid
    1. Computational and Systems Biology
    2. Cancer Biology

    End-to-end proteogenomics for discovery of cryptic and non-canonical cancer proteoforms using long-read transcriptomics and multi-dimensional proteomics

    Katarzyna Kulej, Asher Preska Steinberg ... Alex Kentsis
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cancer Biology
    2. Computational and Systems Biology

    Single-cell atlas of AML reveals age-related gene regulatory networks in t(8;21) AML

    Jessica Whittle, Stefan Meyer ... Mudassar Iqbal
    A comprehensive single-cell atlas of AML uncovers regulatory networks and age-dependent molecular differences to advance the understanding of disease mechanisms and enable subtype-specific therapeutic strategies.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1+ TAMs

    Fangyuan Dong, Shan Zhang ... Shu-Heng Jiang
    Drug repurposing analyses show that citalopram exerts anti-tumor effects by targeting C5aR1 on tumor-associated macrophages to enhance phagocytosis and CD8+ T cell immunity.
    1. Cancer Biology

    Repression of PRMT activities sensitize human homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment

    Youyou Zhang, Mu Xu ... Xiaowen Hu
    Inhibiting PRMT1 and PRMT5 renders HR-proficient ovarian and breast cancers highly vulnerable to PARP inhibition by suppressing BRCAness and amplifying DNA-damage-driven innate immune signaling.
    1. Cancer Biology
    2. Cell Biology

    Mitochondrial protein carboxyl-terminal alanine-threonine tailing promotes human glioblastoma growth by regulating mitochondrial function

    Bei Zhang, Ting Cai ... Zhihao Wu
    The carboxyl-terminal alanine-threonine-tailed protein ATP5α helps glioblastoma mitochondria maintain a high membrane potential and keep the permeability transition pore closed, thereby promoting tumor growth and increasing resistance to apoptosis.
    1. Cancer Biology

    PTEN restrains SHH medulloblastma growth through cell autonomous and nonautonomous mechanisms

    Zhimin Lao, Salsabiel El Nagar ... Alexandra L Joyner
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Cancer Biology

    Identifying tissue states by spatial protein patterns related to chemotherapy response in triple-negative breast cancer

    Luciana M Luque, Mohammad Asif Khan ... Linus J Schumacher
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
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Highlights

    1. Cancer Biology

    Reproducibility in Cancer Biology

    Edited by Roger J Davis et al.
    1. Cancer Biology
    2. Computational and Systems Biology

    eLife publishes final papers from the Reproducibility Project: Cancer Biology

    Timothy M Errington, Maya Mathur ... Brian A Nosek
    1. Cancer Biology

    Toxicity: Fishing for protective compounds

    Giuliano Ciarimboli

Senior editors

  1. Yamini Dalal
    National Cancer Institute, United States
  2. Eduardo Franco
    McGill University, Canada
  3. Tony Ng
    King's College London, United Kingdom
  4. See more editors