Cancer Biology

Latest articles

1. 1. Cancer Biology
   2. Cell Biology

   A versatile system to record cell-cell interactions

   Rui Tang et al.

   A novel reporter system that employs cell surface antigen-nanobody pairing enables physical interaction-dependent labeling and functional modification between diverse cell types.
2. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells

   Xiao Ling Li et al.

   Discovery and initial characterization of a conserved small protein translated from a transcript annotated as a human long non-coding RNA.
3. 1. Cancer Biology

   eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis

   Hang Ruan et al.

   Genetic and transcriptomic analyses revealed that eIF4E S209 phosphorylation enables Myc and mutant KRAS cooperation in colon cancer through stress- and glutamine-dependent growth and addiction.
4. 1. Cancer Biology

   Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma

   Nataša Pavlović et al.

   Inhibiting IRE1α decreases tumor cell proliferation and migration in hepatocellular carcinoma, therefore components of this ER-stress pathway may be therapeutically relevant for liver cancer.
5. 1. Cancer Biology

   Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

   Keerthana Gnanapradeepan et al.

   Enhanced metabolic efficiency associated with the tumor-predisposing African-centric p53 variant.
6. 1. Cancer Biology
   2. Immunology and Inflammation

   The effects of age and systemic metabolism on anti-tumor T cell responses

   Jefte M Drijvers et al.

   A comprehensive literature review delineates the current knowledge of how systemic context, such as age and obesity, can impact CD8⁺ T cell function, anti-tumor immunity, and immunotherapy responsiveness.
7. 1. Cancer Biology

   Protein phase separation and its role in tumorigenesis

   Shan Jiang et al.

   The current understanding of phase separation is summarized and its emerging roles in cancer are discussed in detail.
8. 1. Cancer Biology

   Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen

   Hao Zhang et al.

   The HOXA9 reporter and genetic screens facilitated the functional interrogation of the HOXA9 regulome and advanced our understanding of the molecular regulation network in HOXA9-driven leukemia.
9. 1. Cancer Biology
   2. Genetics and Genomics

   Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway

   Annie Wai Yeeng Chai et al.

   Genome-wide CRISPR/Cas9 screens enable the identification of actionable vulnerabilities of oral squamous cell carcinoma, and their unique dependencies on YAP1 and WWTR1 of the Hippo pathway.
10. 1. Cancer Biology
    2. Immunology and Inflammation

    Cytotoxic T-cells mediate exercise-induced reductions in tumor growth

    Helene Rundqvist et al.

    Exercise can induce metabolic changes that strikingly impact cytotoxic T cell function and in turn affect cancer progression.