Cancer Biology

Latest articles

1. 1. Cancer Biology

   Targeting Polθ Helicase with RP-3467: Preclinical Validation and Clinical Response in a gBRCA1 ovarian cancer patient with an acquired PARPi resistance mutation in TP53BP1

   Ezra Y Rosen, Marie-Claude Mathieu ... Agnel Sfeir
2. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in colorectal cancer

   Qian Wang, Liping Li ... Chuo Chen

   Catalytic inhibition of tankyrase induces tankyrase accumulation and rigidifies the β-catenin destruction complex, limiting its ability to suppress WNT signaling.
3. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

   Sarah M Chang, Muhammad Bin Munim ... Matthew G Vander Heiden

   Examining the metabolic response of cancer cells to nutrient depletion reveals how the cell NAD+/NADH ratio can determine what nutrient environments are compatible with cancer cell proliferation.
4. 1. Cancer Biology

   Impacts of mutation accumulation and order on tumor initiation revealed by engineered murine colorectal cancer organoids

   Yanping Li, Xiaoxin Xie ... Qionghua Zhu

   The temporal order of driver mutations influences colorectal cancer initiation in an immune-dependent manner, highlighting tumor–immune interactions as a context for evolutionary selection.
5. 1. Computational and Systems Biology
   2. Cancer Biology

   Heterogeneous, population-level drug-tolerant persisters exhibit ion-channel remodeling and ferroptosis susceptibility

   Corey E Hayford, Blake Baleami ... Leonard A Harris
6. 1. Cancer Biology
   2. Cell Biology

   Molecular and functional analysis of calcium binding by a cancer-linked calreticulin mutant

   Ishmael Nii Ayibontey Tagoe, Amanpreet Kaur ... Malini Raghavan

   Endoplasmic reticulum and cytosolic calcium levels, and store-operated calcium entry, are comparable in calreticulin-deficient cells rescued with either wild-type calreticulin or the myeloproliferative neoplasm-linked Del52 mutant.
7. 1. Cancer Biology

   An Itch Receptor Drives Melanoma

   Naina Gour, Aishwarya Atakkatan ... Xinzhong Dong
8. 1. Cancer Biology

   JAK-STAT pathway heterogeneity governs immunotherapy response in breast cancer

   Jianbo Zhou, Heng Zhang ... Fu Peng

   Multi-omics investigation identifies cell-type JAK-STAT heterogeneity as a predictive biomarker for PD-1 blockade in breast cancer.
9. 1. Cell Biology
   2. Cancer Biology

   P95-HER2 promotes metastatic progression by biasing MRTFA dependent signaling

   Joseph D Fernandes, Erin Bresnahan ... Joshua C Snyder
10. 1. Cancer Biology
    2. Evolutionary Biology

    Punctuated mutagenesis promotes multi-step evolutionary adaptation in human cancers

    Christopher J Graser, Wenbo Wu ... Franziska Michor

    Evolutionary modeling reveals that punctuated bursts of mutations facilitate fitness-valley crossing in cancer, promoting multi-step adaptation across complex fitness landscapes.