Cancer Biology

Latest articles

1. 1. Cancer Biology

   Dissecting phenotypic transitions in metastatic disease via photoconversion-based isolation

   Yogev Sela et al.

   A photoconversion-based isolation technique enables systematic investigation of spatially distinct small metastases (microcolonies) versus large lesions (macrometastases).
2. 1. Cancer Biology
   2. Computational and Systems Biology

   shinyDepMap, a tool to identify targetable cancer genes and their functional connections from Cancer Dependency Map data

   Kenichi Shimada et al.

   shinyDepMap helps users explore the essentiality, selectivity, and function of the genes across hundreds of cancer cell lines and identify cancer drug targets.
3. 1. Cancer Biology
   2. Neuroscience

   Estrogen receptor alpha in the brain mediates tamoxifen-induced changes in physiology in mice

   Zhi Zhang et al.

   Estrogen receptor alpha in the hypothalamus is required for the effects of chronic tamoxifen treament on gene expression, thermoregulation, bone, and movement in mice.
4. 1. Cancer Biology
   2. Cell Biology

   The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

   Margaret E Torrence et al.
5. 1. Cancer Biology
   2. Genetics and Genomics

   Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells

   Iris E Glykofridis et al.

   Knocking out Folliculin (FLCN) in human renal epithelial cells activates STAT1/2-mediated gene expression, independent of interferon, uncovering a tissue-specific process potentially relevant in the cancer syndrome Birt-Hogg-Dubé (BHD).
6. 1. Cancer Biology
   2. Immunology and Inflammation

   Human primed ILCPs support endothelial activation through NF-κB signaling

   Giulia Vanoni et al.

   Circulating human primed innate lymphoid cell precursors have the potential to functionally induce adhesion molecules' expression in endothelial cells and possibly support the immune cells' infiltration into the tumor site.
7. 1. Cancer Biology

   Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

   Sumiko Takao et al.

   Definition of leukemia gene expression mechanisms reveals general principles of cancer gene control and offers a pharmacologic strategy for its therapeutic reprogramming.
8. 1. Cancer Biology
   2. Immunology and Inflammation

   Tissue-autonomous immune response regulates stress signaling during hypertrophy

   Robert Krautz et al.

   The immune effector Drosomycin buffers stress signaling in hypertrophic salivary glands to inhibit their disintegration, detection by the cellular immune response, and promotes further overgrowth.
9. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells

   Lavanya H Palavalli Parsons et al.

   PARP-7 is a mono(ADP-ribosyl) transferase that directs an extensive ADP-ribosylated proteome to control microtubule stability, and regulate ovarian cancer cell growth and motility.
10. 1. Cancer Biology

    SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance

    Maurizio Fazio et al.

    A genetic discovery screen for epigenetic factors accelerating melanoma development in vivo identifies SATB2 as a driver of tumor invasion and resistance to FDA-approved BRAF-targeted inhibitor Vemurafenib.