Cancer Biology

Cancer Biology

eLife publishes research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cancer Biology
    2. Immunology and Inflammation

    The newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer

    Alison Caldwell et al.
    A recently discovered contagious cancer in the Tasmanian devil has the potential to become widespread in the population due to the loss of histocompatibility antigens that are allogeneic to its hosts.
    1. Cancer Biology
    2. Immunology and Inflammation

    Contagious Cancers: A ‘devil’ of a problem

    Victoria L Hansen, Robert D Miller
    The discovery of a second facial tumor disease in the Tasmanian devil has provided insights into the emergence of contagious cancers.
    Insight
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    1. Cancer Biology
    2. Computational and Systems Biology

    Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes

    Jia-Ren Lin et al.
    t-CyCIF can be used to collect spatially-encoded, multiparametric data from fixed and embedded research or clinical specimens making it possible to probe the organization of tumors and tissues at a single-cell level.
    1. Cancer Biology
    2. Structural Biology and Molecular Biophysics

    Dynamics of human protein kinase Aurora A linked to drug selectivity

    Warintra Pitsawong et al.
    Slow conformational changes after drug binding rationalize selectivity, affinity and long on-target residence time for kinase inhibitors.
    1. Cancer Biology

    Pancreatic Cell Fate: To be or not to be

    Zhe Zhang, Elisabeth Hessmann
    Chromatin remodeling processes can drive acinar cell fate decisions.
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    1. Cancer Biology

    Arid1a restrains Kras-dependent changes in acinar cell identity

    Geulah Livshits et al.
    Arid1a loss in the pancreas enables an irreversible reprogramming of cell fate that is dependent on both cellular and genetic context.
    1. Cancer Biology

    BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions

    Nicolas Bery et al.
    A biosensor resource has been developed to monitor the intracellular interactions of RAS family proteins with effector molecules and the effects of inhibitors as an aid to drug development.

Highlights

    1. Cancer Biology

    Cell fate in the pancreas

    Zhe Zhang, Elisabeth Hessmann
    1. Cancer Biology

    Reproducibility in Cancer Biology

    Curated by Roger Davis et al.

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