Cancer Biology

Latest articles

1. 1. Cancer Biology
   2. Computational and Systems Biology

   A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity

   Adam C Palmer et al.

   Drugs in a curative chemotherapy regimen are independently effective and resisted by different mechanisms, so cancer cells have little chance of surviving all drugs, and this benefit occurs without synergistic interactions.
2. 1. Cancer Biology
   2. Cell Biology

   Junction Mapper is a novel computer vision tool to decipher cell-cell contact phenotypes

   Helena Brezovjakova et al.
3. 1. Cancer Biology

   Philosophy of Biology: Characterizing causality in cancer

   Elena Rondeau et al.

   Ideas about causality from philosophy can help scientists to better understand how cancerous tumors grow and spread in the body.
4. 1. Cancer Biology
   2. Genetics and Genomics

   Antigen presentation and tumor immunogenicity in cancer immunotherapy response prediction

   Shixiang Wang et al.

   Tumor immunogenicity is quantified with a novel method, and the resulting tumor immunogenicity score is an effective tumor-inherent biomarker for prediction of response to immune checkpoint inhibitors.
5. 1. Cancer Biology

   Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts

   Tushar D Bhagat et al.

   Lactate in pancreatic cancer micro-environment can lead to TET enzyme activation and loss of DNA methylation seen in cancer associated fibroblasts.
6. 1. Cancer Biology
   2. Cell Biology

   Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC

   Hao Zeng et al.
7. 1. Cancer Biology
   2. Computational and Systems Biology

   Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome

   Amanda B Abildgaard et al.

   Biophysical modeling, performed in silico, can predict the abundance, metabolic stability, and function of MLH1 inside living cells.
8. 1. Cancer Biology
   2. Microbiology and Infectious Disease

   A single clonal lineage of transmissible cancer identified in two marine mussel species in South America and Europe

   Marisa A Yonemitsu et al.

   A transmissible cancer that arose in a marine mussel spread from a single animal to become a global pathogen affecting two other mussel species in both Europe and South America.
9. 1. Cancer Biology
   2. Human Biology and Medicine

   Improving drug discovery using image-based multiparametric analysis of the epigenetic landscape

   Chen Farhy et al.
10. 1. Cancer Biology
    2. Developmental Biology

    Coopted temporal patterning governs cellular hierarchy, heterogeneity and metabolism in Drosophila neuroblast tumors

    Sara Genovese et al.

    About twenty temporal patterning genes are identified that drive an irreversible differentiation trajectory governing the heterogeneity and proliferative properties of cells in neural tumors with an early developmental origin.