Cancer Biology

Latest articles

1. 1. Cancer Biology

   Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma

   Allison N Lau et al.
2. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   AR phosphorylation and CHK2 kinase activity regulates IR-stabilized AR–CHK2 interaction and prostate cancer survival

   Huy Q Ta et al.

   CHK2 directly binds the AR to mediate transient suppression of AR activity and thus loss of CHK2 function in prostate cancer increases AR activity, DNA damage response and radiation resistance.
3. 1. Cancer Biology

   PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer

   Andrä Brunner et al.

   DNA-PK and PTEN protect breast cancer cells from lethal replication stress induced by the WEE1 inhibitor AZD1775 and constitute new potential biomarkers for AZD1775 sensitivity.
4. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I

   Zoe A Stephenson et al.

   A novel toxicophore, a 1H-1,2,3-triazole, has been identified in a wide-number of therapeutically-relevant compounds, including two anti-cancer chemotherapeutics, which inhibits mitochondria function and is mechanistically linked to adverse cardiac-cell events.
5. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Anti-Cancer Drugs: The mitochondrial paradox

   Sophie L Penman et al.

   A structural motif that is found in two cancer drugs may be responsible for their ability to tackle cancers and for the side-effects caused by the drugs.
6. 1. Cancer Biology

   Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

   Caroline Contat et al.

   In lung adenocarcinoma, deleting one glucose transporter, whether it is Glut1 or Glut3 is insufficient, whereas their dual deletion reduces tumor growth.
7. 1. Cancer Biology

   The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer

   Zane A Gibbs et al.

   Anomalous expression of the testis protein ZNF165 in cancer cells promotes assembly of a neomorphic transcriptional complex that modulates transcription of TGFβ target genes to support tumor cell survival.
8. 1. Cancer Biology
   2. Human Biology and Medicine

   MEIS-mediated suppression of human prostate cancer growth and metastasis through HOXB13-dependent regulation of proteoglycans

   Calvin VanOpstall et al.
9. 1. Cancer Biology

   MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation

   Seiji Arai et al.

   MARCH5 mediates a pathway driving MCL1 degradation in response to cellular stress, which sensitizes to BH3 mimetic drugs targeting BCLXL and provides a broadly effective therapeutic strategy for solid tumors.
10. 1. Cancer Biology
    2. Computational and Systems Biology

    Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions

    Christopher J Lord et al.

    Computational approach to identify reproducible genetic interactions in cancer reveals that they are enriched among protein–protein interaction pairs.