Cancer Biology

Latest articles

1. 1. Cancer Biology
   2. Computational and Systems Biology

   Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions

   Christopher J Lord et al.
2. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I

   Zoe A Stephenson et al.
3. 1. Cancer Biology
   2. Genetics and Genomics

   A highly accurate platform for clone-specific mutation discovery enables the study of active mutational processes

   Mohammad KaramiNejadRanjbar et al.

   A robust library preparation and variant calling strategy (DigiPico/MutLX) eliminates false positive single nucleotide variants from picogram quantities of DNA following whole genome amplification.
4. 1. Cancer Biology
   2. Genetics and Genomics

   Tumor Evolution: Finding the mutations that drive resistance

   Nadine Bley

   Mutations that allow tumors to evolve and become resistant to treatment can be readily identified with a new sequencing approach.
5. 1. Cancer Biology
   2. Genetics and Genomics

   Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing

   Timour Baslan et al.

   Copy number alteration heterogeneity exists in many shapes and forms in breast cancer genomes and single-cell genomics is a powerful tool to further our understanding of its nature and significance.
6. 1. Cancer Biology
   2. Human Biology and Medicine

   Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation

   Tim DD Somerville et al.

   A major consequence of ductal-to-squamous lineage transition in pancreatic cancer cells is to augment inflammation, which may explain the exceptionally poor clinical outcomes of squamous-subtype tumors.
7. 1. Cancer Biology
   2. Immunology and Inflammation

   The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy

   Aaron R Lim et al.

   Diverse components of the tumor microenvironment affect T cell metabolism in ways that are crucial to improving immunotherapy.
8. 1. Cancer Biology
   2. Physics of Living Systems

   Collective forces of tumor spheroids in three-dimensional biopolymer networks

   Christoph Mark et al.

   The forces that multicellular tumor aggregates exert on their environment lead to non-linear, scale-invariant tissue deformations far away from the tumor, which can be exploited to quantify its collective contractility.
9. 1. Cancer Biology
   2. Cell Biology

   TMEM87a/Elkin1, a component of a novel mechanoelectrical transduction pathway, modulates melanoma adhesion and migration

   Amrutha Patkunarajah et al.

   A novel mechanoelectrical transduction pathway can regulate the interactions of melanoma cells and their surrounding microenvironment, impacting both migration and cell dissociation from organotypic spheroids.
10. 1. Cancer Biology

    Replication Study: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

    John Kerwin et al.

    Editors' Summary: This Replication Study has reproduced some parts of the original paper but it also contains results that are not consistent with other parts of the original paper.