Cancer Biology

Cancer Biology

eLife reviews research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Immunology and Inflammation
    2. Cancer Biology

    Integrin-deficient T cell leukemia accumulates in the central nervous system

    Samantha Y Lux, Cynthia Chen ... Susan R Schwab
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Cancer Biology

    Restraint of melanoma progression by cells in the local skin environment

    Yilun Ma, Mohita Tagore ... Richard M White
    Keratinocytes, which activate an EMT-like program in the skin, can prevent melanoma invasion, highlighting how changes in the tumor microenvironment can act as restraining forces in cancer.
    1. Cell Biology
    2. Cancer Biology

    DuoHexaBody-CD37 induces direct cytotoxic signaling in diffuse large B-cell lymphoma

    Simar Pal Singh, Kumar Mangalam ... Annemiek B van Spriel
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Epigenetic and 3D Genome Changes Drive Primary Trastuzumab Resistance in HER2+ Breast Cancer

    Ningjun Duan, Yijia Hua ... Yongmei Yin
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma

    Ariunaa Bayanjargal, Cenny Taslim ... Emily Rose Theisen
    A discrete helix in the fusion oncoprotein DNA binding domain shifts binding preferences toward long and dense GGAA repeats, which promotes transcriptional hub formation and drives EWSR1::FLI1-mediated gene regulation.
    1. Cancer Biology

    JAK-STAT Pathway Heterogeneity Governs Immunotherapy Response in Breast Cancer

    Jianbo Zhou, Heng Zhang ... Fu Peng
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Cancer Biology
    2. Physics of Living Systems

    Heterotypic interfacial tension between oncogenic and wild-type populations forms the mechanical basis of tissue-specific oncogenesis in epithelia

    Amrapali Datta, Phanindra Dewan ... Medhavi Vishwakarma
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Cancer Biology

    Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis

    Patrick B Jonker, Mumina Sadullozoda ... Alexander Muir
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

    Sarah M Chang, Muhammad Bin Munim ... Matthew G Vander Heiden
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Molidustat Targets a Synthetic Lethal Vulnerability in APC-Mutant Colorectal Cancer through GSTP1 and PHD2 Co-Inhibition

    Chiara Asselborn, Agata N Makar ... Alexander von Kriegsheim
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
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Highlights

    1. Cancer Biology
    2. Cell Biology

    Chemotherapy: Lipid balance and chemoresistance in cancer cells

    Kaori Kanemaru, Yoshikazu Nakamura
    1. Cancer Biology

    Breast Cancer: Slowing the growth of drug-resistant tumors

    Yingyi Zhang, Qianying Lu
    1. Cancer Biology

    Transcription Factor-Dependent Cancers: Targeting chromatin remodeling complexes to treat uveal melanoma

    Jonas A Nilsson

Senior editors

  1. Eduardo Franco
    McGill University, Canada
  2. Caigang Liu
    Shengjing Hospital of China Medical University, China
  3. Tony Ng
    King's College London, United Kingdom
  4. See more editors