Cancer Biology

Cancer Biology

eLife reviews research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cell Biology
    2. Cancer Biology

    Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics

    David Papadopoli, Ranveer Palia ... Ivan Topisirovic
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cancer Biology
    2. Developmental Biology

    VGLL2 and TEAD1 fusion proteins identified in human sarcoma drive YAP/TAZ-independent tumorigenesis by engaging EP300

    Susu Guo, Xiaodi Hu ... Junhao Mao
    Characterization of recurrent fusion proteins in rhabdomyosarcoma identified a Hippo pathway-independent mechanism involving VGLL2 and TEAD1 driving oncogenic transformation.
    1. Cancer Biology

    Repression of the Wnt pathway effector TCF7L2 reverses lethal cachexia in mice with intestinal cancers

    Mei Ling Leong, Christiane Ruedl, Klaus Karjalainen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cancer Biology

    KDM5 demethylases suppress R-loop-mediated “viral mimicry” and DNA damage in breast cancer cells

    Lena Lau, Kurt Henderson ... Marie Classon
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cancer Biology

    The context-dependent epigenetic and organogenesis programs determine 3D vs. 2D cellular fitness of MYC-driven murine liver cancer cells

    Jie Fang, Shivendra Singh ... Jun Yang
    Drastic differences in genetic and epigenetic fitness of MYC-driven cancer cells in 3D vs 2D culture.
    Version of Record
    Research Article
    • Important
    • Convincing
    • Incomplete
    1. Cell Biology
    2. Cancer Biology

    Human RAP2A Homolog of the Drosophila Asymmetric Cell Division Regulator Rap2l Targets the Stemness of Glioblastoma Stem Cells

    Maribel Franco, Ricardo Gargini ... Ana Carmena
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cancer Biology

    Molecular Feature-Based Classification of Retroperitoneal Liposarcoma: A Prospective Cohort Study

    Mengmeng Xiao, Xiangji Li ... Li Min
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cancer Biology

    Defined cellular reprogramming of androgen receptor-active prostate cancer to neuroendocrine prostate cancer

    Shan Li, Kai Song ... John K Lee
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Cell Biology
    2. Cancer Biology

    Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP Signaling

    Rachel Nakagawa, Andrew Beardsley ... Andrei Goga
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cancer Biology
    2. Cell Biology

    Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications

    Ida Marie Boisen, Nadia Krarup Knudsen ... Martin Blomberg Jensen
    Testicular microcalcifications arise secondary to local alterations in mineral homeostasis, which in combination with impaired Sertoli cell function and reduced levels of mineralization inhibitors facilitate deposition of hydroxyapatite.
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Highlights

    1. Cancer Biology

    Reproducibility in Cancer Biology

    Edited by Roger J Davis et al.
    1. Cancer Biology
    2. Cell Biology

    Cell crowding and cancer

    Rui Hua, Jean X Jiang
    1. Cancer Biology
    2. Computational and Systems Biology

    eLife publishes final papers from the Reproducibility Project: Cancer Biology

    Timothy M Errington, Maya Mathur ... Brian A Nosek

Senior editors

  1. Yamini Dalal
    National Cancer Institute, United States
  2. Eduardo Franco
    McGill University, Canada
  3. Tony Ng
    King's College London, United Kingdom
  4. See more editors