Cancer Biology

eLife publishes research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Decisions are made by journal editors who are active researchers in cancer biology.

Latest articles

    1. Cancer Biology

    Synergistic interactions with PI3K inhibition that induce apoptosis

    Yaara Zwang et al
    A geneome-scale shRNA screen identifies five genes whose suppression promotes cell death upon PI3K inhibition both in vitro and in vivo, thus suggesting potential combination therapies involving PI3K inhibition.
    Research Article Updated
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    1. Cancer Biology

    Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3

    Ritu Chaudhary et al
    Functional and mechanistic analysis of p53-regulated lncRNA PINCR and its interacting RNA-binding protein Matrin 3 uncovers context-dependent regulation of specific p53 target genes during DNA damage.
    Research Article Updated
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    1. Cancer Biology

    Oncogene Regulation: Enhancers not required

    Ying Zheng, David Levens
    Laboratory mice with over half a megabase of DNA upstream of their Myc gene removed still thrive in the absence of stress.
    Insight
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    1. Cancer Biology
    2. Cell Biology

    Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma

    Giulia Fianco et al
    Retention of Caspase-8 confers a selective advantage to glioblastoma and represents a novel therapeutic target.
    Short Report
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    1. Cancer Biology

    Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth

    Kashyap Dave et al
    A tumor-specific regulatory region has been identified upstream of the Myc oncogene.
    Research Article
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    1. Cancer Biology
    2. Computational and Systems Biology

    Non-coding cancer driver candidates identified with a sample- and position-specific model of the somatic mutation rate

    Malene Juul et al
    A new statistical approach identifies non-coding regulatory regions of genes as driver candidates with recurrent mutations across cancer samples that associate with gene expression, patient survival or mutational phenotype.
    Research Article Updated
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    1. Cancer Biology
    2. Cell Biology

    TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2

    Amy T Ku et al
    Overexpression of TCF7L1 overrides oncogenic Ras-induced senescence, induces cell migration, and promotes growth of skin squamous cell carcinoma independently of its interaction with β-catenin.
    Research Article Updated
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    1. Cancer Biology

    Combined ALK and MDM2 inhibition increases antitumor activity and overcomes resistance in human ALK mutant neuroblastoma cell lines and xenograft models

    Hui Qin Wang et al
    The combination of ceritinib with CGM097 demonstrates remarkable antitumor activity in TP53 wild-type neuroblastoma models with ALK aberrations and is able to overcome the resistance acquired during ceritinib treatment.
    Research Article Updated
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    1. Cancer Biology
    2. Genes and Chromosomes

    Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance

    Rachel W Anantha et al
    Systematic analyses of natural variants and artificial mutants establish functional landscapes of BRCA1 for homology-directed repair (HDR) and therapy resistance and identify the BRCA1-PALB2 interaction as a key control point for HDR pathway choice.
    Research Article Updated
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    1. Cancer Biology
    2. Developmental Biology and Stem Cells

    Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ

    Lorenzo Rinaldi et al
    Dnmt3a and Dnmt3b are dispensable for epidermal homeostasis but act as potent tumor suppressors regarding skin squamous tumorigenesis.
    Research Article Updated
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