Cancer Biology

Latest articles

1. 1. Cancer Biology
   2. Cell Biology

   Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression

   Qiangqiang Liu et al.

   SIAH2 and OTUD5 orchestrate DBC1 ubiquitination and degradation under hypoxic conditions.
2. 1. Cancer Biology
   2. Genetics and Genomics

   Unsupervised detection of fragment length signatures of circulating tumor DNA using non-negative matrix factorization

   Gabriel Renaud et al.

   Non-negative Matrix Factorization is a powerful strategy for unsupervised analysis of cell-free DNA that enables simultaneous estimation of the blood tumor fraction and the fragment length distribution of circulating tumor DNA.
3. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Polysome-CAGE of TCL1-driven chronic lymphocytic leukemia revealed multiple N-terminally altered epigenetic regulators and a translation stress signature

   Ariel Ogran et al.

   Examination of the changes in the transcription start site selection in TCL1-driven chronic lymphocytic leukemia and their impact on mRNA translation revealed a marked elevation of intra-genic cryptic promoters, which are predicted to generate multiple N-terminally truncated or modified proteins.
4. 1. Cancer Biology

   Robust and Efficient Assessment of Potency (REAP) as a quantitative tool for dose-response curve estimation

   Shouhao Zhou et al.

   A novel approach together with a user-friendly web-based analytic tool, coined 'REAP', was proposed to improve the quantitative assessment of dose-response relationship and drug potency.
5. 1. Cancer Biology

   Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery

   Laura M Sipe et al.

   Bariatric surgery reversed obesity-exacerbated tumor burden and increased efficacy of anti-PD-L1 immunotherapy.
6. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context

   Samuel A Kerk et al.

   Inhibition of GOT2 drives growth inhibitory reductive stress that can be rescued by electron acceptors in vitro, whereas GOT2 inhibition in endogenous or transplanted tumor models is tolerated without consequence, highlighting the importance of context when studying tumor metabolism.
7. 1. Cancer Biology
   2. Computational and Systems Biology

   Mapping the single-cell landscape of acral melanoma and analysis of the molecular regulatory network of the tumor microenvironments

   Zan He et al.
8. 1. Cancer Biology
   2. Cell Biology

   The integrated stress response remodels the microtubule-organizing center to clear unfolded proteins following proteotoxic stress

   Brian Hurwitz et al.

   In response to proteotoxic stress, squamous cell carcinoma cells hijack the integrated stress response to promote recovery by bolstering protection of microtubule dynamics.
9. 1. Cancer Biology

   AR-V7 exhibits non-canonical mechanisms of nuclear import and chromatin engagement in castrate-resistant prostate cancer

   Seaho Kim et al.
10. 1. Cancer Biology

    Differentiated glioma cell-derived fibromodulin activates integrin-dependent Notch signaling in endothelial cells to promote tumor angiogenesis and growth

    Shreoshi Sengupta et al.

    Comprehensive proteomic investigation and functional studies unravel an essential role of differentiated glioma cell-secreted fibromodulin (FMOD) in regulating glioblastoma tumor growth by inducing angiogenesis by activating integrin-dependent Notch signaling in endothelial cells, highlighting FMOD as a potential therapeutic target.