Cancer Biology

Latest articles

1. 1. Cancer Biology

   Multi-gradient Permutation Survival Analysis Identifies Mitosis and Immune Signatures Steadily Associated with Cancer Patient Prognosis

   Xinlei Cai, Yi Ye ... Hongbin Ji
2. 1. Cell Biology
   2. Cancer Biology

   Human RAP2A Homolog of the Drosophila Asymmetric Cell Division Regulator Rap2l Targets the Stemness of Glioblastoma Stem Cells

   Maribel Franco, Ricardo Gargini ... Ana Carmena
3. 1. Developmental Biology
   2. Cancer Biology

   Tumors mimic the niche to inhibit neighboring stem cell differentiation

   Yang Zhang, Yuejia Wang ... Shaowei Zhao
4. 1. Cancer Biology

   Causal associations between plasma proteins and prostate cancer: a Proteome-Wide Mendelian Randomization

   Chen Lin, Gu Yanlun ... Pang Xiaocong
5. 1. Cancer Biology

   TopBP1 biomolecular condensates as a new therapeutic target in advanced-stage colorectal cancer

   Laura Morano, Nadia Vezzio-Vié ... Jihane Basbous

   Pharmacological disruption of TopBP1 condensation impairs ATR signaling, promotes DNA damage and apoptosis, and enhances the efficacy of FOLFIRI chemotherapy in colorectal cancer.
6. 1. Cancer Biology

   Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain

   Cassandra C Taber, Wenguang He ... Michael Ohh

   A unique pathogenic mutation on the primary prolyl hydroxylase of the oxygen-sensing pathway compromises the capacity to hydroxylate the hypoxia-inducible factor's N-terminal oxygen-dependent degradation domain proline while retaining activity against the otherwise catalytically predominant C-terminal proline.
7. 1. Cancer Biology

   Blocking Osteoprotegerin Reprograms Cancer Associated Fibroblast to Promotes Immune Infiltration into the Tumor Microenvironment

   Yao Wang, Hara Apostolopoulou ... Anil Bhushan
8. 1. Cancer Biology
   2. Computational and Systems Biology

   BEHAV3D Tumor Profiler to map heterogeneous cancer cell behavior in the tumor microenvironment

   Emilio Rios-Jimenez, Anoek Zomer ... Maria Alieva

   BEHAV3D Tumor Profiler enables researchers without computational expertise to uncover heterogeneous cell behaviors and explore their relationships with microenvironmental features in intravital microscopy data.
9. 1. Chromosomes and Gene Expression
   2. Cancer Biology

   Degradation of LMO2 in T cell leukaemia results in collateral breakdown of transcription complex partners and causes LMO2-dependent apoptosis

   Naphannop Sereesongsaeng, Carole JR Bataille ... Terry H Rabbitts
10. 1. Cancer Biology

    KDM5 demethylases suppress R-loop-mediated ‘viral mimicry’ and DNA damage in breast cancer cells

    Lena Lau, Kurt Henderson ... Marie Classon

    KDM5 inhibition/disruption selectively induces R-loop-mediated DNA damage and innate immune activation in breast cancer cells, while sparing normal cells, unveiling a tumor-specific therapeutic vulnerability with broad translational potential.