Neuronal and glial gradients in the cortex. Image credit: Jill Gregory (CC BY-NC-ND 4.0)
The brain has the ability to adapt after injury, a process known as plasticity. When one area sustains damage, for example following a car accident or stroke, other areas change their activity and structure to compensate. Understanding how this happens is critical to helping people recover from brain injuries. Certain factors may affect how well the brain can repair itself. These include how much the damaged area interacts with other areas, and which cell types different areas of the brain contain.
Froudist-Walsh et al. set out to determine how these factors influence recovery from brain injury in monkeys, whose brains are similar to our own. The monkeys had damage to a structure called the hippocampus. This part of the brain has a key role in memory, which is often impaired in patients with brain injuries. The hippocampus cannot repair itself because the brain has only a limited capacity to grow new neurons. Instead, the brain attempts to compensate for disruption to the hippocampus via changes in other, undamaged areas.
Using brain imaging, Froudist-Walsh et al. show that the types of changes that occur depend on how much time has passed since the injury. In the first three months, many areas of the brain change how much they coordinate their activity with other areas. Highly connected areas reduce their communication with other areas the most. In the long-term, the responses of brain areas depend more on which cell types they contain. Areas with more support cells known as “glia” – which supply nutrients and energy to neurons – are better able to adapt their connectivity up to a year after the injury.
These findings may ultimately benefit people who have suffered brain injuries after accidents or stroke. They suggest that stimulating intact brain areas may be helpful in the months immediately after an injury. By contrast, long-term therapy may need to focus more on structural repair. Future studies must build on these results to discover the best ways to induce successful recovery from brain injury.
