Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Lys417 regulates the opening and closing of SARS-CoV-2 spike protein, allowing SARS-CoV-2 to maintain a delicate balance between infectiousness and evading host immune response.
Rebecca EK Mandt, Madeline R Luth ... Amanda K Lukens
The mutational flexibility of the antimalarial target dihydroorotate dehydrogenase thwarts the use of collateral sensitivity as a strategy to suppress the evolution of resistance.
The coactivity of cortical neurons in associative learning recruits them as associative memory cells based on their synapse interconnections by neuroligin-3-mediated synapse formation, which endorses the first order and the second order of associative memory.
Reanalysis reveals the impact of quality control and differential analysis methods on the discovery of disease-associated genes on the first Alzheimer's disease single-nucleus RNA-seq dataset.
Fear memory intensity modulates brain connectivity patterns, with stronger memories causing a pronounced reduction in interregional coordinated activity and isolation of the amygdala from other key regions.
In C. elegans, neuronic TRPA-1 senses bacterial accumulation by detecting indole production to up-regulate lysozyme genes via FOXO/DAF-16 in the intestine, thereby delaying microbial dysbiosis.
The ability of the therapeutic glucagon-like peptide-1 receptor agonist liraglutide to promote weight loss is partly dependent on signaling via PKA-dependent phosphorylation of the mTORC1 regulator protein Raptor.
