Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Ernie Yulyaningsih, Jung H Suh ... Pascal E Sanchez
DNL343, a brain-penetrant integrated stress response inhibitor, reduces neurodegeneration in mouse models and identifies biomarker candidates for assessing treatment responses in clinical settings.
Stefan Passlick, Ghanim Ullah, Christian Henneberger
Synaptic glutamate release is potentiated by short metabolic failure whereas longer durations of energy depletion lead to a postsynaptic failure of synaptic transmission.
Comparative structural analysis and biochemical characterization unraveled the mechanisms behind enzymatic substrate selectivity, leading to an amplified theanine yield through active mutant protein screening, thus refining strategies for theanine production.
Vglut2-based glutamatergic signaling in central noradrenergic neurons is dispensable for baseline breathing and hypercapnic, hypoxic chemosensory reflexes, which challenges the current understanding of central noradrenergic neurons in breathing control.
OsNF-YB7, an ortholog of Arabidopsis LEC1, is a negative regulator of Chl biosynthesis in rice embryos by interacting with OsGLK1 to inhibit the transactivity of OsGLK1.
Prominin 1 and Tweety Homology 1, two proteins that regulate membrane shape in neural and neuroepithelial cells, have shared evolutionary history and both cause cells to secrete extracellular vesicles.
PPI-hotspotID, trained using an automated machine-learning framework, AutoGluon, on the largest PPI-hot spot dataset to date, detects hot spots beyond protein–protein interfaces, uncovering druggable interactions to aid design of PPI-modulating therapeutics.
Structural studies reveal the mechanism by which the mRNA nuclear export machinery engages with nascent transcripts through interaction with the cap binding complex.
