Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    Expectation-driven gain modulation of preparatory spatial attention

    Dirk van Moorselaar, Stefan van der Stigchel
    Expectations about visual search difficulty enhance processing at attended locations by strengthening attentional signals rather than narrowing the spatial focus of attention.
    1. Genetics and Genomics
    2. Neuroscience

    The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit

    Elizabeth S Kitto, Shijiao Huang ... Scott F Leiser
    Genetic induction of the hypoxic response promotes longevity through a cell-nonautonomous neuronal to intestinal circuit governed by serotonin, tyramine/adrenaline, GABA, and neuropeptide signaling.
    1. Neuroscience

    The resource elasticity of control

    Levi Solomyak, Aviv Emanuel, Eran Eldar
    People effectively estimate how much their control is dependent on the resources they are willing or able to invest, whereas misjudging this relationship is linked to maladaptive behavior and psychopathology.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Spatial confinement induces oscillatory migration of epidermal keratinocytes and forms a three-compartment epithelial structure with epithelial–mesenchymal transition dynamics

    Takuma Nohara, Sota Itamoto ... Ken Natsuga
    Skin cells can preserve the original epithelium while forming a new one beneath 3 µm pores, with passage dependent on actin polymerization and restrained by Piezo1 and keratin 6.
    1. Evolutionary Biology

    Large inversions in Lake Malawi cichlids are associated with habitat, lineage, and sex determination

    Nikesh M Kumar, Taylor L Cooper ... Patrick T McGrath
    Structural variants acquired through ancient hybridization can supply the raw material for ecological divergence while providing the recombination-suppressed background in which sex determination systems operate.
    1. Developmental Biology

    Gcn5 and mTORC1 mediated regulation of autophagy controls Drosophila blood cell homeostasis

    Arjun Aji Reeja, Mincy Kunjumon ... Rohan Jayant Khadilkar
    Gcn5 and mTORC1 cooperatively regulate autophagy to integrate systemic nutritional cues and sustain blood cell homeostasis in Drosophila.
    1. Neuroscience

    Distinct neural representations of perceptual and numerical absence in the human brain

    Benjy Barnett, Stephen M Fleming
    A magnetoencephalography study reveals numerical zero relies on alternative cognitive representations to non-numerical absences in a perceptual detection task.
    1. Neuroscience

    Dopaminergic neurons linking threat processing to cardiac modulation and locomotor responses

    Masato Tsuji, Daisuke Jinkoma ... Kazuo Emoto
    Two pairs of dopaminergic neurons in the fly brain slow the heartbeat in response to threat, and this cardiac deceleration potentially promotes locomotion.
    1. Microbiology and Infectious Disease

    A novel mechanism for morphological change during bacterial sporulation based on programmed peptidoglycan degradation

    Carlos A Ramirez Carbo, Oihane Irazoki ... Beiyan Nan
    The rod-shaped Gram-negative bacterium Myxococcus xanthus forms spherical spores by degrading its peptidoglycan cell wall using two mutually regulating enzymes.
    1. Neuroscience

    Spectraplakin is required for dendritic microtubule organization via a tip-based mechanism in Drosophila

    Matthew Davies, Neeraja Sanal ... Sebastian Rumpf
    Genetic and microscopic analyses reveal that spectraplakin is required for uniform plus end-in organization of neuronal dendritic microtubules and that it acts in a localized and developmentally transient fashion.