Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
A novel, non-invasive strategy combining radiomics and blood extracellular vesicle-derived microRNA profiling to sharpen pancreatic cancer diagnosis is introduced.
Probiotic P118 against Salmonella infections by directly antibacterial actions, inhibiting Salmonella colonization and invasion, attenuating macrophage pro-inflammatory responses, and modulating gut microbiota mediated by microbe-derived indole metabolites.
Isaïh Schwab-Mohamed, Manuel R Mercier ... Daniele Schön
Fine-grained neural dynamics underlying speech coordination are revealed using a real-time interactive synchronous speech task that dissociates functional roles within the dorsal language pathway.
Exercise intensity alone does not differentially reduce pain, but individual factors like fitness level and sex, along with opioid mechanisms, may influence exercise-induced pain relief.
Christina Alexandra Stephens, Niek van Hilten ... Michael Grabe
The majority of TMEM16 lipid scrambling occurs in the open groove associated with Ca2+ activation, but limited scrambling also occurs in the dimer interface independent of Ca2+.
Dominic WH Shayler, Kevin Stachelek ... David Cobrinik
Full-length single-cell RNA-sequencing provide insights into the earliest gene expression programs, the distinct mRNA transcript isoforms, and the retinoblastoma-related cell states associated with human cone and rod photoreceptor development.
Keratinocyte cytonemes mediate essential Notch signaling for proper skin maintenance, with their disruption leading to abnormal differentiation and hyperproliferation resembling human skin disease phenotypes.
