Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Observation of persister cell histories reveals diverse modes of survival in antibiotic persistence

    Miki Umetani, Miho Fujisawa ... Yuichi Wakamoto
    Time-lapse analyses of millions of antibiotic-stressed Escherichia coli characterize the diverse single-cell dynamics of persister cells that depend on antibiotics, culture conditions, and pre-exposure history.
    1. Ecology

    Maternal behavior influences vocal practice and learning processes in the greater sac-winged bat

    Ahana Aurora Fernandez, Nora Serve ... Mirjam Knörnschild
    Non-tutorial feedback shapes song acquisition in a mammalian vocal learner.
    1. Medicine

    Transparency of research practices in cardiovascular literature

    Gabriel O Heckerman, Eileen Tzng ... Adrienne Mueller
    Based on a standardized screening process, the simple majority of reviewed cardiovascular research publications lack sufficient information needed for the study to be replicated or reproduced.
    1. Neuroscience

    Reproducibility of in vivo electrophysiological measurements in mice

    International Brain Laboratory, Kush Banga ... Yizi Zhang
    An electrophysiology dataset generated by 10 laboratories from mice during perceptual decision-making reveals that reproducibility of systems neuroscience data requires stringent histological and electrophysiological quality-control criteria and careful analytical choices.
    1. Neuroscience

    Selective attention and sensitivity to auditory disturbances in a virtually real classroom

    Orel Levy, Shirley Libman Hackmon ... Elana Zion Golumbic
    Neural and gaze-based metrics provide novel insights into individual differences in attention and distractability in a simulated classroom.
    1. Ecology

    Effects of blood meal source and seasonality on reproductive traits of Culex quinquefasciatus (Diptera: Culicidae)

    Kevin Alen Rucci, Gabriel Barco ... Adrián Díaz
    Interaction between blood meal source and seasonality shapes reproductive outputs in Culex quinquefasciatus mosquitoes, providing insight into mechanisms driving seasonal host shift.
    1. Genetics and Genomics
    2. Neuroscience

    Drosophila epidermal cells are intrinsically mechanosensitive and modulate nociceptive behavioral outputs

    Jiro Yoshino, Sonali S Mali ... Jay Z Parrish
    Epidermal mechanosensory responses contribute to acute detection of noxious mechanical stimuli and promote a form of prolonged mechanical hypersensitivity.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Rtf1 HMD domain facilitates global histone H2B monoubiquitination and regulates morphogenesis and virulence in the meningitis-causing pathogen Cryptococcus neoformans

    Yixuan Jiang, Ying Liang ... Youbao Zhao
    Rtf1 HMD is related to H2B ubiquitination and its downstream H3K4 methylation in both C. neoformans and C. deneoformans, thereby affecting its yeast-to-hypha transition and virulence.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Seasonally migratory songbirds have different historic population size characteristics than resident relatives

    Kevin Winker, Kira Delmore
    Paleodemographic analyses in a hypothesis-testing framework show that the major life-history trait of seasonal migration has strong effects on long-term effective population sizes in a clade of songbirds.
    1. Genetics and Genomics
    2. Neuroscience

    Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson’s disease

    Zachary Gaertner, Cameron Oram ... Rajeshwar Awatramani
    A high-resolution atlas of the mouse dopaminergic system was obtained using single-nuclei RNA sequencing and spatial transcriptomics revealing molecular changes in a prodromal model of Parkinson's disease.