Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Improving SARS-CoV-2 variants monitoring in the absence of genomic surveillance capabilities: a serological study in Bolivian blood donors in October 2021 and June 2022

    Lucia Inchauste, Elif Nurtop ... Stéphane Priet
    A pioneering Bolivian seroepidemiological study employed innovative serological and neutralization assays as highly effective complements to genomic surveillance, delivering critical insights into SARS-CoV-2 variant circulation and informing public health strategies.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Effective population size does not explain long-term variation in genome size and transposable element content in animals

    Alba Marino, Gautier Debaecker ... Benoit Nabholz
    A large-scale survey across animals reveals no general association between genome size expansion and the relaxation of natural selection.
    1. Neuroscience

    Mediodorsal thalamic nucleus mediates resistance to ethanol through Cav3.1 T-type Ca2+ regulation of neural activity

    Charles-francois V Latchoumane, Joon-Hyuk Lee ... Hee-Sup Shin
    The firing mode of mediodorsal thalamic neurons may act as a central switching mechanism for the level of arousal and consciousness in natural sleep and induced ethanol hypnosis in mice.
    1. Structural Biology and Molecular Biophysics

    Interpretable protein-DNA interactions captured by structure-sequence optimization

    Yafan Zhang, Irene Silvernail ... Xingcheng Lin
    A predictive biophysical model that integrates protein-DNA structures and sequences to accurately determine genomic binding sites and affinities of DNA-binding proteins.
    1. Neuroscience

    Integration of parallel pathways for flight control in a hawkmoth reflects prevalence and relevance of natural visual cues

    Ronja Bigge, Rebecca Grittner, Anna Lisa Stöckl
    In vision-based flight control of hummingbird hawkmoths, the visual field partitions by natural cue prevalence into an optic flow and dorsal directional pathway, which integrate according to their relevance for flight safety.
    1. Neuroscience

    POMC neurons control fertility through differential signaling of MC4R in kisspeptin neurons

    Rajae Talbi, Todd L Stincic ... Victor M Navarro
    Reproductive impairments in obese MC4R-deficient individuals are due to the absence of melanocortin signaling on Kiss1 neurons and not to their metabolic condition.
    1. Developmental Biology

    Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals

    Yi Wu, Weilin Guo ... Tao Yu
    Pu.1-P53 axis controls the turnover and maintenance of microglia by cell competition.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A whole-organism landscape of X-inactivation in humans

    Bjorn Gylemo, Maike Bensberg, Colm E Nestor
    Genetic analyses of rare non-mosaic females define X-inactivation status for 380 genes and uncover widespread X-chromosome skewing in the general population, providing insights into sex-biased traits and X-linked disease expression.
    1. Cell Biology
    2. Neuroscience

    The myeloid cell-driven transdifferentiation of endothelial cells into pericytes promotes the restoration of BBB function and brain self-repair after stroke

    Tingbo Li, Ling Yang ... Jie-Min Jia
    Changes in the pericyte pool after stroke affect the restoration of the blood-brain barrier function and brain self-repair, and offer a new approach to therapy.
    1. Structural Biology and Molecular Biophysics

    Structure of human PIEZO1 and its slow-inactivating channelopathy mutants

    Yuanyue Shan, Xinyi Guo ... Duanqing Pei
    The architectures of human PIEZO1 and its slow-inactivating channelopathy mutants with or without its auxiliary subunit MDFIC reveal the inactivation mechanism of PIEZO channels.