Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Huazhen Wang, Ludivine Bertonnier-Brouty ... Qi Dai
Hamlet regulates heterotypic epithelial fusion by controlling spatial and temporal expression of known and novel epithelial regulators like Wnt and Tl pathway components, a mechanism potentially conserved through evolution.
Nicolas N Rieser, Milena Ronchetti ... Stephan CF Neuhauss
The neuropeptide galanin modulates whole-brain activity and stress responses in zebrafish, revealing a complex, receptor-dependent role in seizure regulation with implications for epilepsy, and related neurological disorders.
Morgane Batzenschlager, Beatrice Lace ... Thomas Ott
Imaging deep root tissues with a combination of cell-cycle reporters reveals that a cortical cell file traversed by symbiotic bacteria exhibits reduced proliferative potential and enters a prolonged G2 phase.
Fabienne Maassen, Vu Thuy Khanh Le-Trilling ... Mirko Trilling
Through the destabilization of CIITA, the human cytomegalovirus-encoded protein pUS28 antagonizes the expression of the HLA-II molecules CD74/Ii, HLA-DR, HLA-DQ, HLA-DM, and HLA-DP, diminishing the activation of HCMV-specific CD4+ T cells and reducing their secretion of antiviral cytokines.
CCR4 expression in Tregs is critical for limiting proinflammatory Th1 cell-mediated immune responses and atherosclerosis by maintaining the suppressive and migratory functions of Tregs.
Magnetic resonance imaging, through its sensitivity to ionic environments that modulate membrane potential, enables noninvasive assessment of biological systems.