Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Immunology and Inflammation

    Diversity and functional specialization of oyster immune cells uncovered by integrative single-cell level investigations

    Sebastien De La Forest Divonne, Juliette Pouzadoux ... Emmanuel Vignal
    Single-cell and functional analyses uncover distinct immune cell types, revealing specialized functions and deepening insight into invertebrate cellular immunity.
    1. Medicine
    2. Microbiology and Infectious Disease

    HERV activation segregates ME/CFS from fibromyalgia while defining a novel nosologic entity

    Karen Giménez-Orenga, Eva Martín-Martínez ... Elisa Oltra
    Transcriptomic profiling of HERV elements at the loci level differentiates ME/CFS, fibromyalgia, and their overlap, revealing distinct immuno-epigenetic landscapes.
    1. Medicine

    Characterisation and comparison of semen microbiota and bacterial load in men with infertility, recurrent miscarriage, or proven fertility

    Shahriar Mowla, Linda Farahani ... Channa N Jayasena
    There are common seminal microbiome clusters in both healthy men and those with infertility and recurrent pregnancy loss, and some specific microbiota perturbations are associated with impaired semen quality.
    1. Immunology and Inflammation

    Comprehensive analysis of nasal IgA antibodies induced by intranasal administration of the SARS-CoV-2 spike protein

    Kentarou Waki, Hideki Tani ... Nobuyuki Kurosawa
    Analysis of monoclonal immunoglobulin A (IgA) antibodies after intranasal immunization highlights the crucial role of secretory IgA in mucosal immunity, enhancing our understanding of how intranasal vaccines can protect against SARS-CoV-2 infection.
    1. Neuroscience

    Dynamics of striatal action selection and reinforcement learning

    Jack W Lindsey, Jeffrey Markowitz ... Ashok Litwin-Kumar
    A theory of striatal synaptic plasticity separates activity related to learning and action execution into non-interfering subspaces.
    1. Neuroscience

    Non-feature-specific elevated responses and feature-specific backward replay in human brain induced by visual sequence exposure

    Tao He, Xizi Gong ... Fang Fang
    Visual sequence exposure induces non-feature-specific elevated responses and time-compressed feature-specific backward replay, revealing twofold brain plasticity in the human brain.
    1. Neuroscience

    Adolescent alcohol exposure promotes mechanical allodynia and alters synaptic function at inputs from the basolateral amygdala to the prelimbic cortex

    J Daniel Obray, Erik T Wilkes ... L Judson Chandler
    Adolescent alcohol exposure reduced basolateral amygdala-driven inhibition of pyramidal neurons projecting from the prefrontal cortex to the periaqueductal gray and increased inhibition of prefrontal parvalbumin interneurons.
    1. Cancer Biology
    2. Developmental Biology

    VGLL2 and TEAD1 fusion proteins identified in human sarcoma drive YAP/TAZ-independent tumorigenesis by engaging EP300

    Susu Guo, Xiaodi Hu ... Junhao Mao
    Characterization of recurrent fusion proteins in rhabdomyosarcoma identified a Hippo pathway-independent mechanism involving VGLL2 and TEAD1 driving oncogenic transformation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    SIRT2-mediated ACSS2 K271 deacetylation suppresses lipogenesis under nutrient stress

    Rezwana Karim, Wendi Teng ... Hening Lin
    A cross-talk is revealed between two branches of metabolisms, amino acid limitation suppressing fatty acid biosynthesis, via posttranslational modifications of an enzyme involved in fatty acid biosynthesis.
    1. Cell Biology

    MARK2 regulates Golgi apparatus reorientation by phosphorylation of CAMSAP2 in directional cell migratio

    Peipei Xu, Rui Zhang ... Wenxiang Meng
    MARK2-mediated phosphorylation of CAMSAP2 dynamically controls Golgi orientation by altering microtubule anchoring and polarity during directional cell migration.