Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Evolutionary Biology

    Wings and halteres act as coupled dual oscillators in flies

    Tanvi Deora et al.
    Flight system of flies is driven by wings and mechanosensory halteres that operate as independently driven but coupled oscillators, thereby imparting robustness against wing or thorax damage.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts

    Calvin Jon A Leonen et al.
    Chemically sumoylated histone H4 shows negative biochemical crosstalk with gene-activating histone acetylation and methylation marks, and directly inhibits RNA polymerase II-mediated gene transcription.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Rapid and sensitive detection of SARS-CoV-2 infection using quantitative peptide enrichment LC-MS analysis

    Andreas Hober et al.
    Immuno-affinity enrichment combined with liquid chromatography-mass spectrometry can be used to detect viral proteins to confirm the presence of SARS-CoV-2 in clinical samples.
    1. Neuroscience

    A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior

    Shankar Ramachandran et al.
    Investigation of neuromodulatory control of ethologically conserved area-restricted food search behavior shows that NLP-12 stimulation of the head motor circuit promotes food searching through the previously uncharacterized CKR-1 GPCR.
    1. Neuroscience

    Metabolomic profiling reveals a differential role for hippocampal glutathione reductase in infantile memory formation

    Benjamin Bessières et al.
    Hippocampal metabolomic analyses following episodic learning at different ages revealed a critical role for neuronal glutathione reductase activity in long-term infantile memory formation.
    1. Neuroscience

    Attention network modulation via tRNS correlates with attention gain

    Federica Contò et al.
    Parietal noninvasive brain stimulation during perceptual training causes a dramatic increase in learning that correlates with network-wide changes in functional connectivity, demonstrating the stimulation-induced physiological mechanisms leading to cognitive benefits.
    1. Cell Biology

    Proximity labeling identifies LOTUS domain proteins that promote the formation of perinuclear germ granules in C. elegans

    Ian F Price et al.
    A proximity labeling approach defines germ granule proteome in Caenorhabditis elegans, and identifies LOTUS domain proteins as key regulators of germ granule assembly.
    1. Neuroscience

    Circuits for integrating learned and innate valences in the insect brain

    Claire Eschbach et al.
    Electron-microscopy reconstruction and experimental investigation in Drosophila reveal how adaptive action emerges from the multi-level interactions between the output of the olfactory memory center and the innate olfactory pathway.
    1. Biochemistry and Chemical Biology

    The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics

    Astrid Kollewe et al.
    High-resolution proteomics in conjunction with biochemical and electrophysiological experiments revealed that the channel-kinase TRPM7 in rodent brain forms macromolecular complexes containing the metal transporters CNNM1-4 and a small G-protein ARL15.