Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    Visual field map clusters in human frontoparietal cortex

    Wayne E Mackey et al.
    Topographic maps of space in frontal and parietal cortex are organized into clusters, similar to visual cortex, where multiple maps of polar angle share a confluent fovea.
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    1. Genomics and Evolutionary Biology
    2. Microbiology and Infectious Disease

    Exploiting CRISPR-Cas to manipulate Enterococcus faecalis populations

    Karthik Hullahalli et al.
    Conflicts between CRISPR-Cas systems and antibiotic resistance plasmids can be exploited to selectively eliminate antibiotic resistance from Enterococcus faecalis populations.
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    1. Cell Biology
    2. Neuroscience

    Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells

    David Moreno Delgado et al.
    1. Biophysics and Structural Biology
    2. Genes and Chromosomes

    Non-Canonical G-quadruplexes cause the hCEB1 minisatellite instability in Saccharomyces cerevisiae

    Aurèle Piazza et al.
    A combination of genetics and biophysical approaches identifies an overlapping set of sequences that form non-canonical G-quadruplex structures in vitro and induce genomic instability in cells.
    Research Article
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    1. Biochemistry

    Collagen induces activation of DDR1 through lateral dimer association and phosphorylation between dimers

    Victoria Juskaite et al.
    Ligand binding induces DDR1 kinase activity through recruitment of DDR1 receptors into signalling clusters in which phosphorylation occurs across different dimers.
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    1. Biophysics and Structural Biology

    Structural mechanism of ATP-independent transcription initiation by RNA polymerase I

    Yan Han et al.
    Structures of RNA polymerase I transcription machinery revealed a ratcheting motion within the complex in coordination with three distinct functional states, implicating a novel mechanism for promoter bubble opening in the absence of ATP hydrolysis.
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    1. Neuroscience

    Cerebellar re-encoding of self-generated head movements

    Guillaume P Dugué et al.
    The cerebellum encodes self-generated head rotations in a head posture-dependent manner, providing in particular a representation of how the head rotates about axes referenced relative to gravity.
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