Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    Sensory experience controls dendritic structure and behavior by distinct pathways involving degenerins

    Sharon Inberg, Yael Iosilevskii ... Benjamin Podbilewicz
    Mechanosensory isolation of C. elegans nematodes independently induces homeostatic structural changes in the dendritic tree and differential response to mechanical stimulation, both these structural and behavioral outcomes are mediated by degenerins and do not affect presynaptic calcium dynamics.
    1. Neuroscience

    Projections from thalamic nucleus reuniens to hippocampal CA1 area participate in context fear extinction by affecting extinction-induced molecular remodeling of excitatory synapses

    Magdalena Ziółkowska, Narges Sotoudeh ... Kasia Radwanska
    Confocal and electron microscopy analyses reveal that contextual fear extinction induces structural remodeling of thalamic projections to the CA1 area of the hippocampus.
    1. Computational and Systems Biology
    2. Neuroscience

    Multisensory integration operates on correlated input from unimodal transient channels

    Cesare V Parise, Marc O Ernst
    Psychophysical experiments and computational modeling demonstrate the importance of transient, instead of sustained, channels for the integration of audiovisual signals.
    1. Neuroscience

    A double dissociation between semantic and spatial cognition in visual to default network pathways

    Tirso RJ Gonzalez Alam, Katya Krieger-Redwood ... Elizabeth Jefferies
    Default mode network and visual cortex are connected via two parallel pathways that differentially respond to the processing of visual scenes and semantic information about objects, reflecting domain-specific organisation.
    1. Neuroscience

    Multi-study fMRI outlooks on subcortical BOLD responses in the stop-signal paradigm

    Scott Isherwood, Sarah A Kemp ... Birte Forstmann
    A novel meta-analytical method aggregating five SST datasets does not find evidence for the innervation of the hyperdirect or indirect cortico-basal-ganglia pathways in successful response inhibition.
    1. Cell Biology
    2. Neuroscience

    Endopiriform neurons projecting to ventral CA1 are a critical node for recognition memory

    Naoki Yamawaki, Hande Login ... Asami Tanimura
    Unveiling the circuit organization and functional roles of endopiriform neurons projecting to the ventral CA1.
    1. Neuroscience

    Effects of noise and metabolic cost on cortical task representations

    Jake Patrick Stroud, Michal Wojcik ... Mate Lengyel
    The dynamical solutions exhibited by task-optimized recurrent neural networks, and their similarity to prefrontal cortex dynamics, depends strongly on the strength of neural noise and metabolic cost imposed during training.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant

    Patsy R Tomlinson, Rachel G Knox ... Robert K Semple
    PIK3R1 mutations that cause immunodeficiency through PI3-kinase hyperactivation also cause SHORT syndrome, due to PI3-kinase hypofunction, attributable to PI3-kinase destabilisation and outcompetition by mutant PIK3R1.
    1. Neuroscience

    Tripartite organization of brain state dynamics underlying spoken narrative comprehension

    Lanfang Liu, Jiahao Jiang ... Guosheng Ding
    Hidden Markov Modeling to fMRI data reveals how language comprehension arises from the dynamic interplay of large-scale brain networks.
    1. Immunology and Inflammation

    Syngeneic natural killer cell therapy activates dendritic and T cells in metastatic lungs and effectively treats low-burden metastases

    Shih-Wen Huang, Yein-Gei Lai ... Nan-Shih Liao
    IL-15/IL-12-conditioned syngeneic natural killer cells induce long-term survival of tumor-resected mice with established low-burden metastases via activation of dendritic and T cells in the metastatic lung.