Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Computational and Systems Biology
    2. Genetics and Genomics

    Evaluation of in silico predictors on short nucleotide variants in HBA1, HBA2, and HBB associated with haemoglobinopathies

    Stella Tamana, Maria Xenophontos ... Petros Kountouris
    The calibration of decision thresholds will provide evidence for the optimal use of in silico predictors for the standardised classification of globin gene variants under the American College of Medical Genetics and Genomics/Association for Molecular Pathology framework.
    1. Neuroscience

    Oscillations support short latency co-firing of neurons during human episodic memory formation

    Frédéric Roux, George Parish ... Simon Hanslmayr
    Synchronization of neural firing in the medial temporal lobe at fast, but not slow, theta and gamma oscillations correlates with shorter latencies of co-firing and successful memory formation.
    1. Microbiology and Infectious Disease

    Glutamine synthetase mRNA releases sRNA from its 3′UTR to regulate carbon/nitrogen metabolic balance in Enterobacteriaceae

    Masatoshi Miyakoshi, Teppei Morita ... Kan Tanaka
    Under nitrogen limitation, Salmonella and Escherichia coli express a messenger RNA to translate glutamine synthetase, and concomitantly the messenger RNA produces a small RNA from its 3′ end to inhibit the translation of 2-oxoglutarate dehydrogenase of the TCA cycle.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    N6-methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast

    Radhika A Varier, Theodora Sideri ... Folkert J van Werven
    N6-methyladenosine (m6A) reader Pho92 is directed by Paf1C to meiotic mRNAs in an m6A-dependent and independent manner and promotes CCR4-NOT-mediated mRNA decay of m6A modified transcripts contingent on translation.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Molecular basis for the role of disulfide-linked αCTs in the activation of insulin-like growth factor 1 receptor and insulin receptor

    Jie Li, Jiayi Wu ... Eunhee Choi
    A critical role of aCT in the distinct activation mechanism of insulin receptor and insulin-like growth factor 1 receptor.
    1. Neuroscience

    Human hippocampal responses to network intracranial stimulation vary with theta phase

    Sarah M Lurie, James E Kragel ... Joel L Voss
    Human hippocampal connectivity to network afferents varies continuously with the phase of the local theta oscillation, confirming a putative mechanism by which neural oscillations modulate human hippocampal function.