Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Computational and Systems Biology
    2. Ecology

    Microbes with higher metabolic independence are enriched in human gut microbiomes under stress

    Iva Veseli, Yiqun T Chen ... A Murat Eren
    Higher biosynthetic capacity of gut microbes in individuals diagnosed with noncommunicable diseases or taking antibiotics suggests that diversity loss and 'dysbiosis' result from microbiome restructuring in response to ecosystem disruption.
    1. Cell Biology

    Insufficiency of 40S ribosomal proteins, RPS26 and RPS25, negatively affects biosynthesis of polyglycine-containing proteins in fragile-X associated conditions

    Katarzyna Tutak, Izabela Broniarek ... Krzysztof Sobczak
    Identification of ribosomal proteins RPS26 and RPS25, along with chaperone TSR2, as new important modifiers in the noncanonical translation process linked to fragile X premutation disorders.
    1. Neuroscience

    Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans

    Rashi Pant, Kabilan Pitchaimuthu ... Brigitte Röder
    Rare individuals treated for congenital cataracts demonstrated shifts in the visual cortex’s excitatory/inhibitory balance even decades post-surgery, reflected by alterations in the neurotransmitter concentration ratio and aperiodic electroencephalogram activity.
    1. Computational and Systems Biology
    2. Neuroscience

    Sensorimotor delays constrain robust locomotion in a 3D kinematic model of fly walking

    Lili Karashchuk, Jing Shuang Li ... Bingni W Brunton
    A model that simulates realistic fly walking uses an anatomically-inspired layered architecture to achieve robust walking, quantifying the tolerance of this circuit to sensorimotor delays.
    1. Cell Biology
    2. Developmental Biology

    Rudhira-mediated microtubule stability controls TGFβ signaling during mouse vascular development

    Divyesh Joshi, Preeti Jindal ... Maneesha S Inamdar
    The precise integration of endothelial TGFβ signaling and microtubule stability directs cardiovascular development.
    1. Neuroscience

    Mapping serotonergic dynamics using drug-modulated molecular connectivity in rats

    Tudor M Ionescu, Mario Amend ... Kristina Herfert
    PET molecular connectivity is feasible, plausible, and delineates brain-wide pharmacologic effects not identified by BOLD functional connectivity.
    1. Cell Biology
    2. Medicine

    AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism

    Zongwang Zhang, Lixia Zheng ... Jing-Wei Xiong
    AARS2 safeguards cardiomyocytes against ischemic injury by modulating PKM2-driven energy metabolism, revealing the AARS2-PKM2 axis as a previously unrecognized cardioprotective pathway in myocardial infarction.
    1. Cell Biology

    scRNA-seq and scATAC-seq reveal that Sertoli cell mediates spermatogenesis disorders through stage-specific communications in non-obstructive azoospermia

    Shimin Wang, Hongxian Wang ... Dong Zhao
    The specific interaction between Sertoli cell subtypes and germ cell subpopulations mediates spermatogenesis disorders in non-obstructive azoospermia.
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    1. Immunology and Inflammation

    Thymic dendritic cell-derived IL-27p28 promotes the establishment of functional bias against IFN-γ production in newly generated CD4+ T cells through STAT1-related epigenetic mechanisms

    Jie Zhang, Hui Tang ... Yu Zhang
    Dendritic cell (DC)-derived IL-27 establishes CD4+ T cell bias against IFN-γ via STAT1 and epigenetics, linking thymic development to autoimmune mechanisms.
    1. Neuroscience

    Trends in self-citation rates in high-impact neurology, neuroscience, and psychiatry journals

    Matthew Rosenblatt, Saloni Mehta ... Dustin Scheinost
    Self-citation rates differed by geographic region, seniority, gender, and field, which may ultimately affect the perceived influence of authors in these subgroups in neuroscience literature.