Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Biochemistry and Chemical Biology

    Lipid polarity gradient formed by ω-hydroxy lipids in tear film prevents dry eye disease

    Masatoshi Miyamoto et al.
    (O-Acyl)-ω-hydroxy fatty acids and their derivatives, produced by the fatty acid ω-hydroxylase Cyp4f39, form a lipid polarity gradient in the lipid layer of the tear film and prevent dry eye.
    1. Neuroscience

    Separable gain control of ongoing and evoked activity in the visual cortex by serotonergic input

    Zohre Azimi et al.
    Serotonergic input to visual cortex controls ongoing and evoked activity in a separable manner via distinct receptor pathways.
    1. Cell Biology

    A protein quality control pathway at the mitochondrial outer membrane

    Meredith B Metzger et al.
    Temperature-sensitive mitochondrial outer membrane proteins used as novel quality control substrates reveal a unique mitochondria-associated degradation pathway consisting of both cytosolic and mitochondrial ubiquitin-proteasome system machinery.
    1. Immunology and Inflammation

    Reversible promoter methylation determines fluctuating expression of acute phase proteins

    Shi-Chao Zhang et al.
    DNA methylation status can be exploited to finely and reversibly tune the expression of highly inducible genes with CpG-poor promoters in response to environmental cues.
    1. Neuroscience

    Incomplete vesicular docking limits synaptic strength under high release probability conditions

    Gerardo Malagon et al.
    The probability of occupancy of individual synaptic release sites at rest sets an upper limit to synaptic output when increasing action potential related calcium entry.
    1. Microbiology and Infectious Disease

    An atypical DYRK kinase connects quorum-sensing with posttranscriptional gene regulation in Trypanosoma brucei

    Mathieu Cayla et al.
    A trypanosome DYRK kinase that exhibits fundamental differences to conventional DYRK family regulation links parasite quorum sensing, signal transduction and developmental gene expression.
    1. Neuroscience

    Social structure learning in human anterior insula

    Tatiana Lau et al.
    A domain-general structure learning mechanism, supported by anterior insula, moves beyond explicit category labels and dyadic similarity as the sole inputs to social group representations and predicts ally-choice behavior.
    1. Human Biology and Medicine
    2. Stem Cells and Regenerative Medicine

    Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence

    Nicola Alessio et al.
    Protein IGFBP-4 acts as a genotoxic stress mediator that, entering into circulation after its secretion by senescent cells, could promote further senescence phenomena in non-injured cells thus impairing tissues’ homeostasis.
    1. Cell Biology
    2. Developmental Biology

    Endogenous siRNAs promote proteostasis and longevity in germline-less Caenorhabditis elegans

    Moran Cohen-Berkman et al.
    Endo-siRNAs slow down the rate of aging and enable the maintenance of a responsive heat shock response in aging germline-less Caenorhabditis elegans.