Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
In C. elegans, neuronic TRPA-1 senses bacterial accumulation by detecting indole production to up-regulate lysozyme genes via FOXO/DAF-16 in the intestine, thereby delaying microbial dysbiosis.
The ability of the therapeutic glucagon-like peptide-1 receptor agonist liraglutide to promote weight loss is partly dependent on signaling via PKA-dependent phosphorylation of the mTORC1 regulator protein Raptor.
Jeffrey Thompson, Yidi Wang ... Ulrich H von Andrian
A claims-based retrospective cohort study shows that patients who used bisphosphonates between 01/01/2019 and 02/29/2020 had dramatically reduced odds of SARS-CoV-2 testing, COVID-19 diagnosis, and COVID-19-related hospitalizations during the initial surge of the COVID-19 pandemic in the US.
The decrease in alpha rhythm amplitude in the parietal regions after the presentation of a deviant auditory stimulus gives rise to a part of the P300-evoked response.
Taylor N Medwig-Kinney, Brian A Kinney ... David Q Matus
Dynamic compartmentalization of the pro-invasive transcription factor NHR-67 reveals a role for members of the Groucho/TCF repressive complex in maintaining non-invasive cell fate in C. elegans.
Manfred G Kitzbichler, Daniel Martins ... Neil A Harrison
Revealing two distinct brain systems linked to obesity, this research illuminates the intricate relationship between obesity, brain microstructure and genetics with potential implications for treatment and prevention.
When reading natural passages with or without a question in mind, the time reading each word is explained by deep neural networks optimized for information-retrieval or word prediction tasks, respectively.
Chromatin profiling of Drosophila testes reveals activation of the transcriptional program of the germline, widespread changes in RNA polymerase progression, and the absence of chromosomal regulation across the X chromosome.
