Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Cell Biology
    2. Genes and Chromosomes

    Post-meiotic DNA double-strand breaks occur in Tetrahymena, and require Topoisomerase II and Spo11

    Takahiko Akematsu et al.
    The first genetic compelling evidence for post-meiotic DNA double-strand breaks and its relation to chromatin remodeling in haploid pronuclei is shown.
    Research Article Updated
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biophysics and Structural Biology
    2. Cell Biology

    9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments

    Svetlana O Dodonova et al.
    A molecular model of the assembled COPI coat, determined by cryo-electron tomography of an in vitro reconstituted budding reaction, reveals details of interactions mediating coat assembly and shows the binding site of ArfGAP2.
    Research Article Updated
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Epidemiology and Global Health
    2. Genomics and Evolutionary Biology

    The Anopheles gambiae 2La chromosome inversion is associated with susceptibility to Plasmodium falciparum in Africa

    Michelle M Riehle et al.
    A common chromosome inversion in African malaria mosquito (Anopheles gambiae) is associated with differences in malaria infection, adult resting behavior and ecology, and may aid the most efficient vectors to evade malaria control.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cancer Biology
    2. Cell Biology

    MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect

    Charles DeRossi et al.
    1. Genomics and Evolutionary Biology

    On the mechanistic nature of epistasis in a canonical cis-regulatory element

    Mato Lagator et al
    Thermodynamic framework accurately predicts the sign of epistasis and its environment dependence for a canonical cis-regulatory element.
    Research Article Updated
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    MeCP2 regulates Tet1-catalyzed demethylation, CTCF binding, and learning-dependent alternative splicing of the BDNF gene in Turtle

    Zhaoqing Zheng et al
    Loss of MeCP2 function negatively impacts Tet1 and CTCF binding thereby negatively impacting learning-dependent DNA methylation and alternative splicing regulation.
    Research Article Updated
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Genetic specification of left–right asymmetry in the diaphragm muscles and their motor innervation

    Camille Charoy et al
    Analysis of embryonic mouse diaphragm reveals muscle and nerve left–right asymmetries set by a Nodal-dependent genetic cascade, which imprints different molecular signatures to left and right motoneurons that shape their innervation pattern.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf