Research Articles

Latest articles

1. 1. Neuroscience

   Motor cortex can directly drive the globus pallidus neurons in a projection neuron type-dependent manner in the rat

   Fuyuki Karube et al.

   Globus pallidus neurons projecting to the striatum are preferentially activated by direct glutamatergic innervation from the motor cortex.
2. 1. Cell Biology

   Negative regulation of autophagy by UBA6-BIRC6–mediated ubiquitination of LC3

   Rui Jia, Juan S Bonifacino

   An ensemble of the ubiquitin-activating enzyme UBA6 and ubiquitin-conjugating enzyme/ubiquitin-ligase BIRC6 mediates ubiquitination of LC3, targeting the latter for proteasomal degradation and thus attenuating autophagic degradation of cellular substrates.
3. 1. Physics of Living Systems

   Length regulation of multiple flagella that self-assemble from a shared pool of components

   Thomas G Fai et al.

   In the microbe Chlamydomonas reinhardtii, a disassembly rate which depends on flagellar length provides an effective method to regulate the length of its two flagella.
4. 1. Cancer Biology
   2. Computational and Systems Biology

   A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity

   Adam C Palmer et al.
5. 1. Neuroscience

   Excitatory neurons are more disinhibited than inhibitory neurons by chloride dysregulation in the spinal dorsal horn

   Kwan Yeop Lee et al.
6. 1. Cancer Biology
   2. Cell Biology

   Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC

   Hao Zeng et al.
7. 1. Neuroscience

   Elevating acetyl-CoA levels reduces aspects of brain aging

   Antonio Currais et al.
8. 1. Developmental Biology
   2. Neuroscience

   Cerebellar nuclei excitatory neurons regulate developmental scaling of presynaptic Purkinje cell number and organ growth

   Ryan T Willett et al.
9. 1. Neuroscience

   Local axonal morphology guides the topography of interneuron myelination in mouse and human neocortex

   Jeffrey Stedehouder et al.
10. 1. Cell Biology
    2. Neuroscience

    A proline-rich motif on VGLUT1 reduces synaptic vesicle super-pool and spontaneous release frequency

    Xiao Min Zhang et al.

    In mammals, the vesicular glutamate transporter 1 acquired a proline-rich sequence that negatively regulates the spontaneous release of glutamate by reducing the exchange of synaptic vesicles along the axon.