Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite

    Abhinay Ramaprasad, Paul-Christian Burda ... Michael J Blackman
    The malaria parasite uses an enzyme called GDPD to absorb choline, an important nutrient, from the bloodstream and this is essential for the parasite to survive inside the red blood cell.
    1. Medicine

    Dysregulation of the PRUNE2/PCA3 genetic axis in human prostate cancer: from experimental discovery to validation in two independent patient cohorts

    Richard C Lauer, Marc Barry ... Wadih Arap
    PRUNE2/PCA3 axis dysregulation is an early, rather than late, event in prostate cancer tumorigenesis.
    1. Developmental Biology

    Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nanoarchitecture in flight muscles

    Florian Schueder, Pierre Mangeol ... Frank Schnorrer
    The two Drosophila titin homologs Sallimus and Projectin display a precise tandem arrangement in the sarcomere that may explain how sarcomere length is regulated outside of vertebrates.
    1. Cell Biology
    2. Neuroscience

    Gain-of-function variants in the ion channel gene TRPM3 underlie a spectrum of neurodevelopmental disorders

    Lydie Burglen, Evelien Van Hoeymissen ... Joris Vriens
    Newly identified gain-of-function variants indicate TRPM3 as the cause of a spectrum of autosomal dominant neurodevelopmental disorders with frequent cerebellar involvement in humans.
    1. Physics of Living Systems

    Geometric control of Myosin-II orientation during axis elongation

    Matthew F Lefebvre, Nikolas H Claussen ... Sebastian J Streichan
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Plasmodium infection disrupts the T follicular helper cell response to heterologous immunization

    Mary F Fontana, Erica Ollmann Saphire, Marion Pepper
    Flow cytometric analysis of antigen-specific B and T cell responses to heterologous immunization reveals intact dendritic cell function, but selective defects in germinal center formation, in mice with concurrent malaria.
    1. Cell Biology
    2. Neuroscience

    Growth cone advance requires EB1 as revealed by genomic replacement with a light-sensitive variant

    Alessandro Dema, Rabab A Charafeddine ... Torsten Wittmann