Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Medicine

    PSTPIP2 ameliorates aristolochic acid nephropathy by suppressing interleukin-19-mediated neutrophil extracellular trap formation

    Changlin Du, Chuanting Xu ... Taotao Ma
    PSTPIP2 reduced IL-19 secretion by inhibiting activation of the NF-κB pathway in renal tubular epithelial cells (RTECs), reducing the generation of neutrophil extracellular trap, which can participate in both aristolochic acid I-induced renal injury and apoptosis in RTECs.
    1. Cell Biology
    2. Physics of Living Systems

    The positioning mechanics of microtubule asters in Drosophila embryo explants

    Jorge de-Carvalho, Sham Tlili ... Ivo A Telley
    Using cytosolic explants from Drosophila syncytial embryos combined with quantitative microscopy and perturbations, the mechanical forces separating Drosophila microtubule asters are revealed.
    1. Neuroscience

    Tracking subjects' strategies in behavioural choice experiments at trial resolution

    Silvia Maggi, Rebecca M Hock ... Mark D Humphries
    1. Structural Biology and Molecular Biophysics

    Structure of the two-component S-layer of the archaeon Sulfolobus acidocaldarius

    Lavinia Gambelli, Mathew McLaren ... Bertram Daum
    CryoEM reveals the structure of a two-component archaeal S-layer, which sheds new light on archaeal cell biology.
    1. Computational and Systems Biology
    2. Neuroscience

    Endotaxis: A neuromorphic algorithm for mapping, goal-learning, navigation, and patrolling

    Tony Zhang, Matthew Rosenberg ... Markus Meister
    A neural circuit model reveals how biological brains may implement rapid learning and navigation in complex spaces.
    1. Genetics and Genomics

    Characterization of caffeine response regulatory variants in vascular endothelial cells

    Carly Boye, Cynthia A Kalita ... Francesca Luca
    Caffeine modulates the genetic risk for cardiovascular disease through changes in target gene expression, likely due to regulation of transcription factor binding.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis

    Pengfei Guo, Rebecca C Lim ... Hui Zhang
    EZH2 is regulated by a K20-methylation dependent proteolysis and this proteolysis process is negatively controlled by AKT-mediated S21 phosphorylation to establish a methylation-phosphorylation switch to control the PRC2 activity and hematopoiesis.
    1. Microbiology and Infectious Disease

    Host and viral determinants of airborne transmission of SARS-CoV-2 in the Syrian hamster

    Julia R Port, Dylan H Morris ... Vincent J Munster
    An experimental animal model provides further insights into the host and viral mechanisms underlying airborne transmission of SARS-CoV-2.
    1. Evolutionary Biology

    Evolutionary rate covariation is a reliable predictor of co-functional interactions but not necessarily physical interactions

    Jordan Little, Maria Chikina, Nathan L Clark
    Physical interactions are a minor contributor to the correlations in evolutionary rate over time that are observed between co-functional proteins.
    1. Cell Biology
    2. Genetics and Genomics

    A seven-sex species recognizes self and non-self mating-type via a novel protein complex

    Guanxiong Yan, Yang Ma ... Wei Miao
    A giant multifunctional protein complex mediates mating-type recognition through a non-ligand–receptor mechanism in a multisexual species.