Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Developmental Biology
    2. Physics of Living Systems

    Spectral decomposition unlocks ascidian morphogenesis

    Joel Dokmegang, Emmanuel Faure ... Madhav Mani
    The blueprint and narrative of shape formation during early development can be objectively observed by quantifying and analyzing whole-embryo dynamics.
    1. Neuroscience

    Rate of brain aging associates with future executive function in Asian children and older adults

    Susan F Cheng, Wan Lin Yue ... Juan Helen Zhou
    A longitudinal, deep learning approach reveals challenges and opportunities in establishing brain age as an effective metric of aging, with particular consideration given to underrepresented populations in Asia.
    1. Developmental Biology
    2. Neuroscience

    Microglia are required for developmental specification of AgRP innervation in the hypothalamus of offspring exposed to maternal high-fat diet during lactation

    Haley N Mendoza-Romero, Jessica E Biddinger ... Richard Simerly
    Hypothalamic microglia play an essential role in mediating changes to feeding circuitry caused by exposure to maternal HFD that may contribute to developmental programming of metabolic phenotype.
    1. Microbiology and Infectious Disease

    Stumpy forms are the predominant transmissible forms of Trypanosoma brucei

    Jean Marc Tsagmo Ngoune, Parul Sharma ... Brice Rotureau
    According to experimental and field observations, stumpy forms appear to be the most adapted forms for African trypanosome transmission from the mammalian host to the tsetse fly in natural conditions.
    1. Neuroscience

    Predictive learning rules generate a cortical-like replay of probabilistic sensory experiences

    Toshitake Asabuki, Tomoki Fukai
    Biologically plausible synaptic plasticity rules enable recurrent neural networks to spontaneously replay sensory experiences with appropriate probabilistic structure.
    1. Neuroscience

    Morphology and ultrastructure of external sense organs of Drosophila larvae

    Vincent Richter, Anna Rist ... Andreas S Thum
    Advanced electron microscopy techniques have been applied to comprehensively describe the cellular details and ultrastructural characteristics of all sensilla within the external sensory system of Drosophila larvae.
    1. Neuroscience

    Four individually identified paired dopamine neurons signal taste punishment in larval Drosophila

    Denise Weber, Katrin Vogt ... Andreas S Thum
    A neurogenetic approach reveals the cellular division of labor between individual Drosophila larval dopaminergic neurons encoding an averive teaching signal, reflecting principles in the adult insect and vertebrate brain.
    1. Computational and Systems Biology
    2. Neuroscience

    A common alteration in effort-based decision-making in apathy, anhedonia, and late circadian rhythm

    Sara Z Mehrhof, Camilla L Nord
    Individuals with a late circadian rhythm show the same deficits in motivational decision-making as those with neuropsychiatric symptoms, but only when tested in the morning.
    1. Neuroscience

    Precise spatial tuning of visually driven alpha oscillations in human visual cortex

    Kenichi Yuasa, Iris IA Groen ... Jonathan Winawer
    Separating alpha oscillations from broadband activity reveals that alpha suppression in the human visual cortex is highly localized, and modulates cortical state in a manner consistent with exogenous spatial attention.
    1. Neuroscience

    Neural substrates of cold nociception in Drosophila larva

    Atit A Patel, Albert Cardona, Daniel N Cox
    Functional neural circuit dissection identifies sensorimotor responses to noxious cold in Drosophila larvae revealing complex mechanisms by which nervous systems sense and respond to cold.