Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Microbiology and Infectious Disease

    Heavy isotope labeling and mass spectrometry reveal unexpected remodeling of bacterial cell wall expansion in response to drugs

    Heiner Atze et al.
    Labeling with 13C and 15N in the absence of metabolic engineering enabled the exploration of peptidoglycan metabolism at a very fine level of detail based on kinetic characterization of isotopologues predicted to occur according to known recycling and biosynthesis pathways.
    1. Cell Biology
    2. Developmental Biology

    Androglobin, a chimeric mammalian globin, is required for male fertility

    Anna Keppner et al.
    Androglobin, a newly identified mammalian globin with a unique modular structure including a protease and calmodulin binding IQ domain within a circularly permuted globin domain, is implicated in murine spermatogenesis.
    1. Developmental Biology
    2. Evolutionary Biology

    An epithelial signalling centre in sharks supports homology of tooth morphogenesis in vertebrates

    Alexandre P Thiery et al.
    The development of diverse tooth shapes among vertebrates, from sharks to mammals, is a highly conserved process, utilising a similar dental signalling centre for more than 400 million years.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Visualizing molecules of functional human profilin

    Morgan L Pimm et al.
    Fluorescently-tagged profilin-1 behaves similar to the tag-free protein in biochemical and cell-based assays.
    1. Biochemistry and Chemical Biology

    A native chemical chaperone in the human eye lens

    Eugene Serebryany et al.
    The human eye lens imports and concentrates within itself a naturally abundant small molecule that inhibits cataract-associated aggregation of an eye lens protein before the aggregates get large enough to scatter light.