Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Immunology and Inflammation

    Glutamine metabolism modulates chondrocyte inflammatory response

    Manoj Arra et al.
    Glutamine deprivation reprograms chondrocytes, attenuates inflammation, and such intervention may be protective against joint inflammation.
    1. Cell Biology

    Modular, cascade-like transcriptional program of regeneration in Stentor

    Pranidhi Sood et al.
    Regeneration of single Stentor coeruleus cells is accompanied by a program of gene expression that can be decomposed into distinct modules, showing a cascade-like organization, and involving genes with conserved function in development and cell cycle control.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Full spectrum flow cytometry reveals mesenchymal heterogeneity in first trimester placentae and phenotypic convergence in culture, providing insight into the origins of placental mesenchymal stromal cells

    Anna Leabourn Boss et al.
    Full spectrum flow cytometry reveals a high degree of placental mesenchymal cell heterogeneity, which is lost with culture, highlighting the importance of detailed ex vivo phenotyping to optimise the use of these cells in downstream applications.
    1. Computational and Systems Biology
    2. Ecology

    A systematic, complexity-reduction approach to dissect the kombucha tea microbiome

    Xiaoning Huang et al.
    Kombucha tea microbiome analysis demonstrates the identification, characterization and extrapolation of minimal cores as a promising framework for mechanistic investigation of microbiome behaviors.
    1. Neuroscience

    Connectomic analysis of the Drosophila lateral neuron clock cells reveals the synaptic basis of functional pacemaker classes

    Orie T Shafer et al.
    The most influential clocks within the Drosophila circadian clock neuron network form the fewest synapses within the network, and neurons that do not themselves contain molecular clocks mediate connections between those that do, suggesting a key role in timekeeping.
    1. Structural Biology and Molecular Biophysics

    Ancestral acetylcholine receptor β-subunit forms homopentamers that prime before opening spontaneously

    Christian JG Tessier et al.
    Reconstructed ancestral muscle-type acetylcholine receptor β-subunits readily form homopentameric ion channels that open spontaneously, and display functional hallmarks of the modern-day heteropentameric receptor despite being devoid of canonical agonist-binding sites.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Large protein complex interfaces have evolved to promote cotranslational assembly

    Mihaly Badonyi, Joseph A Marsh
    Analysis of protein interfaces suggests cotranslational assembly can be an adaptive process, likely serving to minimise non-specific interactions with other proteins in the cell.
    1. Immunology and Inflammation

    Natural killer (NK) cell-derived extracellular-vesicle shuttled microRNAs control T cell responses

    Sara G Dosil et al.
    Extracellular vesicles derived from natural killer cells contain a specific repertoire of microRNAs that promote Th1 responses.