Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Cell Biology

    Stratification of enterochromaffin cells by single-cell expression analysis

    Yan Song, Linda J Fothergill ... Gene W Yeo
    Molecularly defined serotonin (enterochromaffin) cells of the gut lining were distinguished by single-cell expression analysis, in situ hybridization, and immunohistochemistry into 14 topographically organized clusters, with features implying that they are functionally distinct classes of serotonin cells.
    1. Ecology
    2. Evolutionary Biology

    Reconstructing the phylogeny and evolutionary history of freshwater fishes (Nemacheilidae) across Eurasia since early Eocene

    Vendula Bohlen Šlechtová, Tomáš Dvořák ... Joerg Bohlen
    The first comprehensive reconstruction of the evolutionary history of freshwater animals, on example of family Nemacheilidae, across Eurasia with the identification of the main tectonic, geological, and climatic factors influencing it has been described.
    1. Developmental Biology

    Mesenchymal Meis2 controls whisker development independently from trigeminal sensory innervation

    Mehmet Mahsum Kaplan, Erika Hudacova ... Ondrej Machon
    Meis2 transcription factor instructs the mesenchyme to initiate whisker formation in the epithelium.
    1. Microbiology and Infectious Disease

    Linalool combats Saprolegnia parasitica infections through direct killing of microbes and modulation of host immune system

    Tao Tang, Weiming Zhong ... Zhipeng Gao
    Linalool demonstrates dual antimicrobial and immunomodulatory actions against Saprolegnia parasitica.
    1. Neuroscience
    2. Physics of Living Systems

    Annihilation of action potentials induces electrical coupling between neurons

    Moritz Schloetter, Georg U Maret, Christoph J Kleineidam
    Action potentials of neurons expel a charge when they reach the axon terminal, and classical electrodynamics predict the resulting electric fields and its influence to other neurons by ephaptic coupling.
    1. Immunology and Inflammation

    CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cells

    Xiaoyu Meng, Yezhang Zhu ... Lie Wang
    CXXC1 is a pivotal epigenetic regulator that ensures Treg homeostasis and suppressive function by interacting with FOXP3 to modulate H3K4me3 deposition at key signature genes.
    1. Plant Biology

    The rhizobial effector NopT targets Nod factor receptors to regulate symbiosis in Lotus japonicus

    Hanbin Bao, Yanan Wang ... Yangrong Cao
    The rhizobial effector NopT and two Nod factor receptors of Lotus japonicus, NFR1 and NFR5, mutually interact to precisely regulate rhizobial symbiosis.
    1. Cell Biology

    Small-molecule activation of TFEB alleviates Niemann–Pick disease type C via promoting lysosomal exocytosis and biogenesis

    Kaili Du, Hongyu Chen ... Dan Li
    Small-molecule agonists of transcription factor EB alleviate Niemann–Pick disease type C via promoting lysosomal function.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Control of pili synthesis and putrescine homeostasis in Escherichia coli

    Iti Mehta, Jacob B Hogins ... Larry Reitzer
    Putrescine has a homeostatic network that controls pili synthesis and energy metabolism.
    1. Neuroscience

    Visual routines for detecting causal interactions are tuned to motion direction

    Sven Ohl, Martin Rolfs
    Visual adaptation in humans revealed that the perception of causality was tuned to the direction of motion while the adaptation transferred across different motion speeds and colors.