Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Analysis of an essential motif in Mcm4 provides insights into replicative helicase double-hexamer formation and the first step requiring this intermediate during replication initiation.
A novel engineered protein that uncouples electrical signals from downstream biological responses in excitable cells provides a unique investigative tool with potential therapeutic applications.
Two anatomically and genetically distinct subtypes of spinal V2b neurons provide inhibition onto motor circuits and serve as a brake on locomotor speed.
USP49 can increase A3G protein expression and enhance its anti-HIV-1 activity, which is also correlated with hypermutations and affects the HIV-1 latent reservoir.
Targeting the CRL5 ubiquitin ligase complex in combination with CDK9 or MCL1 inhibition could combat innate and acquired resistance of cancer cells to MCL1-targeting therapeutics.
Telomeric TRF1 controls the transcriptional programmes of pluripotent stem cells by recruiting PRC2 to pluripotency and differentiation genes by controlling the expression of those gene sites and the binding of TERRA RNAs to them.
Polarizing susceptibilities to recurrent bladder infection are shaped by a duality in TNFɑ-mediated inflammation dynamics upon challenge infection that is dictated by the outcome of the initial infection.
