Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Cell Biology

    Novel mechanism for tubular injury in nephropathic cystinosis

    Swastika Sur, Maggie Kerwin ... Minnie M Sarwal
    ATP6V0A1 was identified as a key player in nephropathic cystinosis-related renal pathology, with antioxidants like ATX emerging as potential treatments to restore V0A1 expression, mitochondrial function, and balance autophagic processes.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Single-cell RNA sequencing of the holothurian regenerating intestine reveals the pluripotency of the coelomic epithelium

    Joshua G Medina-Feliciano, Griselle Valentín-Tirado ... José E Garcia-Arraras
    The intestinal coelomic epithelium provides dedifferentiated precursor cell populations that drive the adult holothurian intestinal regeneration.
    1. Ecology

    Genetic diversity affects ecosystem functions across trophic levels as much as species diversity, but in an opposite direction

    Laura Fargeot, Camille Poesy ... Blanchet Simon
    Genetic diversity is strongly associated with ecosystem functions across natural trophic chains, showing that it can be as important as species diversity.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition

    Gülnihal Kavaklioglu, Alexandra Podhornik ... Christian Seiser
    DNA hypomethylation in human tumor cells results in the activation of the LINE-1-derived RNA-binding protein L1TD1 and its interactions with LINE-1 transposons.
    1. Neuroscience

    Mesoscale functional organization and connectivity of color, disparity, and naturalistic texture in human second visual area

    Hailin Ai, Weiru Lin ... Peng Zhang
    V2 exhibits interdigitated columnar organizations for color and disparity that involved feedforward and feedback processing, while the texture selectivity is primarily driven by feedback modulations from V4.
    1. Neuroscience

    Two long-axis dimensions of hippocampal-cortical integration support memory function across the adult lifespan

    Kristin Nordin, Robin Pedersen ... Alireza Salami
    Multimodal imaging reveals overlapping gradients of hippocampal connectivity reflecting patterns of cortical function, dopamine receptor distribution, and individual differences in memory, with age-related dedifferentiation of gradient organization marking cognitive decline.
    1. Cell Biology
    2. Developmental Biology

    Rediscovering the rete ovarii, a secreting auxiliary structure to the ovary

    Dilara N Anbarci, Jennifer McKey ... Blanche Capel
    The rete ovarii is a complex secretory structure that may play an important role in ovarian homeostasis.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The genomic legacy of aurochs hybridisation in ancient and modern Iberian cattle

    Torsten Günther, Jacob Chisausky ... Cristina Valdiosera
    After their introduction to the Iberian peninsula, domestic cattle hybridised with mostly male wild aurochs for millennia until human actions likely ended this process about 4000 years ago.
    1. Developmental Biology

    The autophagy protein ATG14 safeguards against unscheduled pyroptosis activation to enable embryo transport during early pregnancy

    Pooja Popli, Arin K Oestreich ... Ramakrishna Kommagani
    Autophagy sustains oviduct homeostasis, modulates inflammation, and prevents excessive pyroptosis, ensuring efficient embryo transport and a well-balanced reproductive tract environment.