Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Elliot Howard-Spink, Tetsuro Matsuzawa ... Dora Biro
Long-term standardized data collection on wild western chimpanzees reveals late-life changes in stone tool use, and the extent of these changes varies between individuals.
Saloni Goyal, Divya Rajendran ... Athi N Naganathan
Polyphosphate, a universal stress response regulator, binds distinctively to different starting ensembles of the same protein leading to either condensates or aggregates that in turn can solubilize or further aggregate, showcasing their ability to finely control the assembly process.
Customized AlphaFold-based modeling of distinct functional states of the hERG channel, a major drug anti-target, significantly improves drug affinity predictions, enhancing cardiac safety screening for arrhythmia risk.
Joseph M Barnby, Jen Nguyen ... London Personality and Mood Disorders Consortium
Individuals with borderline personality disorder maintain rigid, distinct self-other representations, disrupting the bidirectional generalisation that underpins adaptive social learning and interpersonal trust.
Two lateral striatal subregions integrate the acquisition of stimulus-based decision-making in spatiotemporally and functionally different manners, challenging the prior model through a dominance change from the associative to sensorimotor subregions.
Claire Cooper, Daniel Parthier ... Dietmar Schmitz
The fine-tuning of mutual inhibition and disinhibition of sleep-regulating neurons and also the memory consolidation that occurs during NREM sleep are controlled by oscillations in serotonin levels.
In methicillin-resistant Staphylococcus aureus, evolution of bacteriophage resistance causes trade-offs that re-sensitize the bacteriato β-lactam antibiotics.
