Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Indole produced during dysbiosis mediates host–microorganism chemical communication

    Rui-Qiu Yang, Yong-Hong Chen ... Cheng-Gang Zou
    In C. elegans, neuronic TRPA-1 senses bacterial accumulation by detecting indole production to up-regulate lysozyme genes via FOXO/DAF-16 in the intestine, thereby delaying microbial dysbiosis.
    1. Cell Biology
    2. Medicine

    Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide

    Thao DV Le, Dianxin Liu ... Julio E Ayala
    The ability of the therapeutic glucagon-like peptide-1 receptor agonist liraglutide to promote weight loss is partly dependent on signaling via PKA-dependent phosphorylation of the mTORC1 regulator protein Raptor.
    1. Epidemiology and Global Health
    2. Medicine

    Association between bisphosphonate use and COVID-19 related outcomes

    Jeffrey Thompson, Yidi Wang ... Ulrich H von Andrian
    A claims-based retrospective cohort study shows that patients who used bisphosphonates between 01/01/2019 and 02/29/2020 had dramatically reduced odds of SARS-CoV-2 testing, COVID-19 diagnosis, and COVID-19-related hospitalizations during the initial surge of the COVID-19 pandemic in the US.
    1. Neuroscience

    Event-related modulation of alpha rhythm explains the auditory P300-evoked response in EEG

    Alina Studenova, Carina Forster ... Vadim Nikulin
    The decrease in alpha rhythm amplitude in the parietal regions after the presentation of a deviant auditory stimulus gives rise to a part of the P300-evoked response.
    1. Neuroscience

    Catecholaminergic neuromodulation and selective attention jointly shape perceptual decision-making

    Stijn A Nuiten, Jan Willem de Gee ... Simon van Gaal
    Pharmacologically elevated catecholamine levels and spatial attention jointly shape perceptual decision-making, revealed by unique, similar, and interactive effects on behavior, drift diffusion modeling parameters, and electrophysiology.
    1. Developmental Biology

    Dynamic compartmentalization of the pro-invasive transcription factor NHR-67 reveals a role for Groucho in regulating a proliferative-invasive cellular switch in C. elegans

    Taylor N Medwig-Kinney, Brian A Kinney ... David Q Matus
    Dynamic compartmentalization of the pro-invasive transcription factor NHR-67 reveals a role for members of the Groucho/TCF repressive complex in maintaining non-invasive cell fate in C. elegans.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The genomic footprint of social stratification in admixing American populations

    Alex Mas Sandoval, Sara Mathieson, Matteo Fumagalli
    1. Neuroscience

    Two human brain systems micro-structurally associated with obesity

    Manfred G Kitzbichler, Daniel Martins ... Neil A Harrison
    Revealing two distinct brain systems linked to obesity, this research illuminates the intricate relationship between obesity, brain microstructure and genetics with potential implications for treatment and prevention.
    1. Neuroscience

    Human attention during goal-directed reading comprehension relies on task optimization

    Jiajie Zou, Yuran Zhang ... Nai Ding
    When reading natural passages with or without a question in mind, the time reading each word is explained by deep neural networks optimized for information-retrieval or word prediction tasks, respectively.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Chromosome-specific maturation of the epigenome in the Drosophila male germline

    James T Anderson, Steven Henikoff, Kami Ahmad
    Chromatin profiling of Drosophila testes reveals activation of the transcriptional program of the germline, widespread changes in RNA polymerase progression, and the absence of chromosomal regulation across the X chromosome.