Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Computational and Systems Biology
    2. Neuroscience

    Subunit exchange enhances information retention by CaMKII in dendritic spines

    Dilawar Singh, Upinder Singh Bhalla
    Due to subunit-exchange, CaMKII can store information at diverse time-scales and might play a central role in the memory maintenance.
    1. Structural Biology and Molecular Biophysics

    The CryoEM structure of the Saccharomyces cerevisiae ribosome maturation factor Rea1

    Piotr Sosnowski et al.
    The high-resolution structure of Rea1, an essential ribosome maturation factor in Saccharomyces cerevisiae, explains how the ATPase domain is regulated and reveals the linker domain, the mechanical element carrying out ribosome remodeling.
    1. Structural Biology and Molecular Biophysics

    CryoEM structures of open dimers of gyrase A in complex with DNA illuminate mechanism of strand passage

    Katarzyna M Soczek et al.
    CryoEM structures of open gyrase A dimers and DNA in two states representing steps either prior to or after passage through the DNA-gate, show where a putative T-segment is found.
    1. Immunology and Inflammation

    A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death

    Shigetoshi Yokoyama et al.
    A novel pathway was discovered for cellular uptake of LPS through secretory protein secretoglobin3A2 and a receptor syndecan-1, causing activation of non-canonical inflammasome pathway leading to pyroptosis of cancer cells.
    1. Neuroscience

    Spatial sampling in human visual cortex is modulated by both spatial and feature-based attention

    Daniel Marten van Es et al.
    The sampling of visual space is not only warped by attention towards locations but also depends on attended features.
    1. Developmental Biology
    2. Physics of Living Systems

    Theoretical tool bridging cell polarities with development of robust morphologies

    Silas Boye Nissen et al.
    Biological shapes and morphological transitions can emerge from combining directed interactions between cells with apical-basal and planar cell polarity.