A mandarin vole father and mother take care of their offspring. Image credit: Ma Huan (CC BY 4.0)
Parental care early in life is essential for normal development of the brain in humans and some other animals. It also lays the ground work for healthy behaviors later in life. Many studies have looked at the importance of a mother’s care, but less attention has been paid to the role played by fathers. Research shows that children who grow up without a father are at risk of emotional and behavioral problems later in life. But it is not clear how missing a father’s care affects brain development.
Oxytocin, a chemical produced by a part of the brain called the paraventricular nucleus, plays a key role in parental bonding. Another part of the brain called the prelimbic cortex regulates many emotions and many complex behaviors. Studying animals, like the mandarin vole, that form strong bonds with both parents is one way to learn more about how the loss of paternal care affects oxytocin or emotional and behavioral health.
Now, He et al. show that mandarin voles raised without a father are more anxious and socialize less with other voles than those raised with a father. The voles deprived of paternal care also have fewer oxytocin-producing cells in the paraventricular nucleus and fewer receptors for oxytocin in the prelimbic cortex. Injecting oxytocin into the prelimbic cortex eliminated the anxious and antisocial behavior seen in the voles lacking paternal care. Using a technique called optogenetics to restore the release of oxytocin in the prelimbic cortex reduced anxious behavior and restored normal social interactions. Using the same approach to interfere with communication between the paraventricular nucleus and prelimbic cortex in voles raised with a father also triggered anxious and antisocial behavior.
The experiments reveal that fathers play an important role in brain and behavioral development in mandarin voles. He et al. show that a lack of paternal care leads to deficits in oxytocin and a poor communication between the paraventricular nucleus and prelimbic cortex that contribute to emotional and social abnormalities in the voles. More studies are needed to determine father’s care has similar effects in humans. But if this relationship is confirmed, it might lead scientists to develop new strategies for treating psychiatric disorders in people deprived of paternal care.
