Sensory neuron. Image credit: Isabella Gavazzi (CC BY 4.0)
Humans see, hear, feel, taste and smell the world as spiking electrical signals in the brain encoded by sensory neurons. Sensory neurons learn from experience to adjust their activity when exposed repeatedly to the same stimuli. A loud noise or that strange taste in your mouth might be alarming at first but soon sensory neurons dial down their response as the sensations become familiar, saving energy.
This neural adaptation has been observed experimentally in individual cells, but it raises questions about how the brain deciphers signals from sensory neurons. How do downstream neurons learn whether the reduced activity from sensory neurons is a result of getting used to a feeling, or a signal encoding a weaker stimulus? The energy saved through neural adaptation cannot come at the expense of sensing the world less accurately. Neural networks in our brain have evidently evolved to code information in a way that is both efficient and accurate, and computational neuroscientists want to know how. There has been great interest in reproducing neural networks for machine learning, but computer models have not yet captured the mechanisms of neural coding with the same eloquence as the brain.
Gutierrez and Denève used computational models to test how networks of sensory neurons encode a sensible signal whilst adapting to new or repeated stimuli. The experiments showed that optimal neural networks are highly cooperative and share the load when encoding information. Individual neurons are more sensitive to certain stimuli but the information is encoded across the network so that if one neuron becomes fatigued, others receptive to the same stimuli can respond. In this way, the network is both responsive and reliable, producing a steady output which can be readily interpreted by downstream neurons.
Exploring how stimuli are encoded in the brain, Gutierrez and Denève have shown that the activity of one neuron does not represent the whole picture of neural adaptation. The brain has evolved to adapt to continuous stimuli for efficiency at both the level of individual neurons and across balanced networks of interconnected neurons. It takes many neurons to accurately represent the world, but only as a network can the brain sustain a steady picture.
