A sex cell (green) can communicate with a different mating partner (purple) more efficiently when it sends out ligands (green circles) that cannot bind to receptors on its own surface. Image credit: Hadjivasiliou and Pomiankowski (CC BY 4.0)
Sexual reproduction, from birds to bees, relies on distinct classes of sex cells, known as gametes, fusing together. Most single cell organisms, rather than producing eggs and sperm, have similar sized gametes that fall into distinct ‘mating types’. However, only sex cells belonging to different mating types can fuse together and sexually reproduce.
At first glance, it seems illogical that cells from the same mating type cannot reproduce with each other, as this restricts eligible partners within a population and makes finding a mate more difficult. Yet the typical pattern amongst single cell organisms is still two distinct classes of sex cells, just as in birds and bees. How did the obsession with mating between two different types become favored during evolution?
One possibility is that cells with different mating types can recognize and communicate with each other more easily. Cells communicate by releasing proteins known as ligands, which bind to specific receptors found on the cell’s surface. Using mathematical modelling, Hadjivasiliou and Pomiankowski showed that natural selection typically favors ‘asymmetric’ signaling, whereby cells evolve to either produce receptor A with ligand B, or have the reverse pattern and produce receptor B with ligand A. These asymmetric mutants are favored because they avoid producing ligands that clog or activate the receptors on their own surface. As a result, different types of cells are better at recognizing each other and mating more quickly.
When cells sexually reproduce they exchange genetic material with each other to produce offspring with a combination of genes that differ to their own. However, if the genes coding for ligand and receptor pairs were constantly being ‘swapped’, this could lead to new combinations, and a loss of asymmetric signaling. Hadjivasiliou and Pomiankowski showed that for asymmetric signaling to evolve, natural selection favors the genes encoding these non-compatible ligand and receptor pairs to be closely linked within the genome. This ensures that the mis-matching ligand and receptor are inherited together, preventing cells from producing pairs which can bind to themselves.
This study provides an original way to address an evolutionary question which has long puzzled biologists. These findings raise further questions about how gametes evolved to become the sperm and egg, and how factors such as signaling between cells can determine the sex of more complex organisms, such as ourselves.
