How to court a fly

Innate behaviors are behaviors that do not need to be learned. They include activities such as nest building in birds and web spinning in spiders. Another behavior that has been extensively studied, and which is generally considered to be innate, is courtship in fruit flies. Male fruit flies serenade potential mates by vibrating their wings to create a complex melody. This behavior is under the control of a gene called ‘fruitless’, which gives rise to several distinct proteins, including one that is unique to males. For many years, this protein – called Fru^M – was thought to be the master switch that activates courtship behavior.

But recent findings have challenged this idea. They show that although male flies that lack Fru^M fail to show courtship behaviors if raised in isolation, they can still learn them if raised in groups. This suggests that the role of Fru^M is more complex than previously thought. To determine how Fru^M controls courtship behavior, Chen et al. have used genetic tools to manipulate Fru^M activity in male flies at different stages of the life cycle and distinct cells of the nervous system.

The results revealed that Fru^M must be present during a critical period of development – but not adulthood – for male flies to court females. However, Fru^M strongly influences the type of courtship behavior the male flies display. The amount and location of Fru^M determines whether males show heterosexual, homosexual or bisexual courtship behaviors. Adult flies with lower levels of Fru^M show an increase in homosexual courtship and a decrease in heterosexual courtship.

These findings provide a fresh view on how a master gene can generate complex and flexible behaviors. They show that fruitless, and the Fru^M protein it encodes, work distinctly at different life cycles to modify the type of courtship behavior shown by male flies, rather than simply switching courtship behavior on and off. Exactly how Fru^M acts within the fruit fly brain to achieve these complex effects requires further investigation.