A Short Report allows authors to publish the results of a small number of experiments, provided the conclusion is clear and justified, and the findings are novel and judged to be of high importance.
A high-throughput chemical screen identifies ligands of the Kelch domain of E3 ligase KLHDC2 capable of being modified as proteolysis-targeting chimeras.
Rachel Kaletsky, Rebecca S Moore ... Coleen T Murphy
Deviating from established protocols is the most likely reason why Gainey et al. (2024) could not reproduce earlier results in a Caenorhabditis elegans transgenerational inheritance paradigm, and the earlier findings are also supported by tests with over 30 new genes.
A Sofia F Oliveira, Fiona L Kearns ... Adrian J Mulholland
Equilibrium and nonequilibrium simulations uncover how the fatty acid site in the SARS-CoV-2 spike modulates protein dynamics, revealing its intricate allosteric connections and the impact of glycans on these networks.
RIM-Deep enhances imaging depth in confocal microscopy enabling high-quality visualization of large cleared samples across various fields with minimal cost.
Sergio Casas-Tinto, Nuria Garcia-Guillen, María Losada-Perez
Genetic and lineage-tracing analyses reveal that neuropil-associated glia can directly transdifferentiate into neurons in the adultcentral nervous system (CNS) after injury, uncovering a previously unrecognised mechanism for CNS regeneration.
Cerebellar Purkinje cells make direct synapses within the parabrachial, vestibular, pontine central gray, and other brainstem nuclei that exhibit spatial gradients and cell specificity consistent with nuanced influences on diverse behaviors.
