A Short Report allows authors to publish the results of a small number of experiments, provided the conclusion is clear and justified, and the findings are novel and judged to be of high importance.
High-resolution mapping of RNA polymerase II transcripts shows that the directionality of mammalian promoters is determined by preferential transcriptional initiation and the opposing activities of Integrator and CDK9.
This time-shortened work flow improves sensitivity and specificity for the identification of bacteria in bone infections independently of bacterial culturability.
The 'low water' agar assay provides a reliable and practical high-throughput method for studying plant molecular signaling responses to drought stress.
Weiting Zhang, Karl Petri ... Jing-Ruey Joanna Yeh
Strategic pegRNA designs and other approaches mitigating 5' and 3' interactions within pegRNAs can often lead to substantial improvements in prime editing efficiency.
Broader global access to Paxlovid, coupled with appropriately timed treatment, can mitigate the severity and transmission of SARS-Cov-2 as the virus and the landscape of immunity continue to evolve.
Alexandra Stavsky, Leonardo A Parra-Rivas ... Daniel Gitler
Alpha-synuclein binding to the synapsin E-domain is essential and sufficient for their cooperation in attenuating synaptic-vesicle trafficking and neurotransmission.
Genetic and biochemical approaches reveal that mammalian cells possess a novel DDI2 and transcription-independent pathway for the rapid recovery of proteasome activity after clinically relevant pulse treatment with proteasome inhibitors.
