Short Reports

A Short Report allows authors to publish the results of a small number of experiments, provided the conclusion is clear and justified, and the findings are novel and judged to be of high importance.

Latest articles

    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Transposase-assisted tagmentation of RNA/DNA hybrid duplexes

    Bo Lu et al.
    Tn5 transposase has direct tagmentation activity towards RNA/DNA hybrids, which is harnessed as a more convenient and faster RNA-seq library construction method and will benefit RNA and chromatin research.
    1. Computational and Systems Biology
    2. Neuroscience

    Stable task information from an unstable neural population

    Michael E Rule et al.
    Analysis and modelling of sensorimotor neural activity shows how ongoing plasticity and appropriately tuned weights can cope with substantial ongoing changes in the neural code.
    1. Genetics and Genomics
    2. Human Biology and Medicine

    Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging

    Sebastian I Arriola Apelo et al.
    Metabolic health and longevity can be separated by ovariectomy, which also protects female mice lacking hepatic mTORC2 from midlife mortality.
    1. Computational and Systems Biology
    2. Human Biology and Medicine

    SARS-CoV-2 strategically mimics proteolytic activation of human ENaC

    Praveen Anand et al.
    SARS-CoV-2 has evolved to cleverly mimic the FURIN-cleavage site in human ENaC-α, unlike any prior coronavirus strain, shedding new light on the Acute Respiratory Distress Syndrome (ARDS) in COVID-19 patients.
    1. Structural Biology and Molecular Biophysics

    Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity

    Lukas M Langer et al.
    First structural view of a substrate-bound PIKK (PI3K-related-kinase) by cryo-EM explains phosphorylation specificity toward a short amino-acid motif shared across the PIKK family and rationalizes PIKK auto-inhibition by regulatory domain.
    1. Cell Biology
    2. Neuroscience

    Synaptotagmin-1 is the Ca2+ sensor for fast striatal dopamine release

    Aditi Banerjee et al.
    Genetic and electrophysiological analyses reveal calcium-triggering mechanisms for dopamine release in the striatum that may enable fast and slow dopamine coding.
    1. Plant Biology

    Lack of evidence for associative learning in pea plants

    Kasey Markel
    A fully blinded replication of the most convincing report of associative learning in plants failed to reproduce the phenomenon.