A Short Report allows authors to publish the results of a small number of experiments, provided the conclusion is clear and justified, and the findings are novel and judged to be of high importance.
Full-length, autoinhibited LRRK2 assembles into distinct, shorter microtubule-bound filaments via a previously unobserved N-terminal repeat interface, revealing new structural states with potential therapeutic implications.
scRNA+TCR-seq technology identifies a high proportion of dual TCR Treg cells in both lymphoid and non-lymphoid tissues of mice, revealing their tissue specificity, TCR repertoire characteristics, and functional phenotypes.
Evidence for H. naledi and increasing recognition of meaning-making behavior across the later Pleistocene suggests that the hominin emotional, socio-cognitive niche is broader and more significant than previously thought.
Climbing fiber activity gates the acquisition phase of motor learning but becomes nonessential for memory consolidation or performance once proficiency is achieved.
Marie-Alphée Laurent, Corentin Jacques ... Bruno Rossion
There is a striking correspondence between face-selective neural increases vs decreases of fMRI BOLD signal and spikes in neighboring human fusiform gyrus regions.
While persistent aggressive states in females are promoted by select cell types with recurrent connections (aIPg, pC1d+e), additional data and models are needed to explain the maintenance of these states.
Huanhuan Joyce Chen, Eric E Gardner ... Harold Varmus
A human pluripotent stem cell-based model demonstrates how TP53/RB1 loss and MYC overexpression drive aggressive, neuroendocrine small cell lung cancer progression and metastasis, enabling investigation of tumor heterogeneity and therapeutic response in a defined genetic context.
The selector gene mirror defines the far posterior wing domain in butterflies, revealing how ancestral axial subdivisions have been evolutionarily reduced in Drosophila.
A high-throughput chemical screen identifies ligands of the Kelch domain of E3 ligase KLHDC2 capable of being modified as proteolysis-targeting chimeras.
