Short Reports

A Short Report allows authors to publish the results of a small number of experiments, provided the conclusion is clear and justified, and the findings are novel and judged to be of high importance.

Latest articles

    1. Genetics and Genomics

    Enhancing CRISPR prime editing by reducing misfolded pegRNA interactions

    Weiting Zhang, Karl Petri ... Jing-Ruey Joanna Yeh
    Strategic pegRNA designs and other approaches mitigating 5' and 3' interactions within pegRNAs can often lead to substantial improvements in prime editing efficiency.
    1. Neuroscience

    Adult-born granule cells modulate CA2 network activity during retrieval of developmental memories of the mother

    Blake J Laham, Isha R Gore ... Elizabeth Gould
    Adult-born granule cell projections are necessary for CA2 network activity and retrieval of developmental social memories.
    1. Cancer Biology

    Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

    Keene L Abbott, Ahmed Ali ... Matthew G Vander Heiden
    Assessing metabolites in renal cell carcinoma and kidney tissue suggests cancers adapt rather than dictate nutrient availability.
    1. Epidemiology and Global Health

    A retrospective cohort study of Paxlovid efficacy depending on treatment time in hospitalized COVID-19 patients

    Zhanwei Du, Lin Wang ... Lauren A Meyers
    Broader global access to Paxlovid, coupled with appropriately timed treatment, can mitigate the severity and transmission of SARS-Cov-2 as the virus and the landscape of immunity continue to evolve.
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    1. Neuroscience

    Drift of neural ensembles driven by slow fluctuations of intrinsic excitability

    Geoffroy Delamare, Yosif Zaki ... Claudia Clopath
    Internal neural variability can induce drift of memory ensembles through synaptic plasticity, allowing for encoding of temporal information.
    1. Cell Biology
    2. Neuroscience

    Synapsin E-domain is essential for α-synuclein function

    Alexandra Stavsky, Leonardo A Parra-Rivas ... Daniel Gitler
    Alpha-synuclein binding to the synapsin E-domain is essential and sufficient for their cooperation in attenuating synaptic-vesicle trafficking and neurotransmission.
    1. Cancer Biology
    2. Cell Biology

    Early recovery of proteasome activity in cells pulse-treated with proteasome inhibitors is independent of DDI2

    Ibtisam Ibtisam, Alexei F Kisselev
    Genetic and biochemical approaches reveal that mammalian cells possess a novel DDI2 and transcription-independent pathway for the rapid recovery of proteasome activity after clinically relevant pulse treatment with proteasome inhibitors.
    1. Neuroscience

    Stimulation of VTA dopamine inputs to LH upregulates orexin neuronal activity in a DRD2-dependent manner

    Masaya Harada, Laia Serratosa Capdevila ... Tommaso Patriarchi
    Optogenetic manipulation and photometry recordings in the lateral hypothalamus show how interactions between dopamine and orexin systems underlie reward expectation revealing dopaminergic modulation of orexinergic activity via D2 receptors.
    1. Neuroscience

    The pelvic organs receive no parasympathetic innervation

    Margaux Sivori, Bowen Dempsey ... Jean-François Brunet
    Of the two divisions proposed long ago to describe the autonomic nervous system, thoraco-lumbar sympathetic and cranio-sacral parasympathetic, the latter finds no support from transcriptionally defined neuron types.
    1. Computational and Systems Biology

    Sensitive remote homology search by local alignment of small positional embeddings from protein language models

    Sean R Johnson, Meghana Peshwa, Zhiyi Sun
    Protein language deep learning models can quickly and accurately translate amino acid sequences into profile hidden Markov models or a structure alphabet, dramatically improving remote homology search sensitivity without compromising space or time efficiency.