A Short Report allows authors to publish the results of a small number of experiments, provided the conclusion is clear and justified, and the findings are novel and judged to be of high importance.
Genetic lineage tracing and live-cell imaging demonstrate that NeuroD1 does not convert microglia into neurons but instead promotes microglial apoptosis, challenging claims of in situ glia-to-neuron conversion.
Joel Kowalewski, Barbara F Baer-Imhoof ... Anandasankar Ray
Honey bee olfactory aversion can be modeled using machine learning to iteratively discover bee-selective repellents, validated in free-flying assays, that can potentially reduce contact with pesticides.
Social context modulates innate defensive behaviors in a rank- and threat-dependent manner, while threat experience reinforces social roles, revealing a bidirectional interplay between defensive and social behavior.
Jeevan Tewari, Benjamin W Dahl ... Jeffrey J Saucerman
Current general-purpose large language models generate signaling and metabolic networks with only modest accuracy relative to manually curated network models.
Minimally disruptive genetic code expansion enables faithful, site-specific labeling of G3BP1 and TDP-43, revealing native stress granule dynamics and ALS-linked protein behavior in live cells.
Eleonore Schiltz, Martijn Broux ... Haesler Sebastian
The representation of stimulus identity and experience is transformed from primary olfactory cortex to memory-related multisensory areas in the hippocampus.
Using computational and theoretical models shows how adult-neurogenesis and spike-timing-dependent plasticity balance the flexibility and stability of odor representations.
