A Short Report allows authors to publish the results of a small number of experiments, provided the conclusion is clear and justified, and the findings are novel and judged to be of high importance.
Jeevan Tewari, Benjamin W Dahl ... Jeffrey J Saucerman
Current general-purpose large language models generate signaling and metabolic networks with only modest accuracy relative to manually curated network models.
Minimally disruptive genetic code expansion enables faithful, site-specific labeling of G3BP1 and TDP-43, revealing native stress granule dynamics and ALS-linked protein behavior in live cells.
Eleonore Schiltz, Martijn Broux ... Haesler Sebastian
The representation of stimulus identity and experience is transformed from primary olfactory cortex to memory-related multisensory areas in the hippocampus.
Using computational and theoretical models shows how adult-neurogenesis and spike-timing-dependent plasticity balance the flexibility and stability of odor representations.
Transcriptomic heterogeneity in infective-stage surface proteins of Trypanosoma cruzi, particularly trans-sialidase-like superfamily members, suggests distinct expression profiles among individual parasites that may enhance immune evasion and infection adaptability.
Rigorous analysis in two knockout mouse lines demonstrates that death receptor 6 is not required for axon degeneration or Schwann cell injury responses following peripheral nerve transection.
Vikash Verma, Patricia Wadsworth, Thomas J Maresca
TIRF imaging of CRISPR-edited human cells shows dynein–dynactin complexes move processively with motility parameters consistent with the presence of multi-dynein assemblies (>one dynein heavy chain dimer per dynactin) in cells.
Mahesh A Vibhute, Corbin Machatzke ... Hannes Mutschler
Structure-guided engineering of a bacterial retron enables intracellular production of a light-up DNA aptamer whose purified DNA retains dye-activated fluorescence, establishing retrons as a scalable route to cellular aptamer synthesis.
Visible light engages a non-visual, bZIP-dependent transcriptional pathway in peripheral tissues that communicates with the nervous system to shape behavioral plasticity and memory, enabling optogenetic-like gene control without photoreceptors.
