Short Reports

A Short Report allows authors to publish the results of a small number of experiments, provided the conclusion is clear and justified, and the findings are novel and judged to be of high importance.

Latest articles

    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Structure of the IL-27 quaternary receptor signaling complex

    Nathanael A Caveney et al.
    The cryogenic-electron microscopy structure of IL-27 bound to receptors, IL-27Rα and gp130, revealing a three-site assembly mechanism and overall topology and molecular details reminiscent of IL-6 but distinct from related IL-12 and IL-23.
    1. Ecology

    Regional opportunities for tundra conservation in the next 1000 years

    Stefan Kruse, Ulrike Herzschuh
    The treeline follows climate warming with a severe time lag, but migration rates are increasing so that only under ambitious mitigation efforts will 30% of original tundra areas remain in the north in the long run.
    1. Immunology and Inflammation
    2. Medicine

    The DNA sensors AIM2 and IFI16 are SLE autoantigens that bind neutrophil extracellular traps

    Brendan Antiochos et al.
    A novel extracellular role for cytoplasmic DNA sensors in shielding NET DNA from DNase-mediated degradation.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Genetic variation in ALDH4A1 is associated with muscle health over the lifespan and across species

    Osvaldo Villa et al.
    Leveraging the US Health and Retirement Study and C. elegans genetics reveals ALDH4A1/alh-6 as an evolutionarily conserved biomarker for normal muscle function over the lifespan.
    1. Developmental Biology
    2. Medicine

    VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development

    Derek C Sung et al.
    VE-cadherin is required for trophoblast invasion of the maternal decidua and spiral arteries.
    1. Developmental Biology
    2. Immunology and Inflammation

    A functional screen of RNA binding proteins identifies genes that promote or limit the accumulation of CD138+ plasma cells

    David J Turner et al.
    A genetic screening approach identifies RNA binding proteins that enhance or inhibit the accumulation of CD138+ plasma cells in vitro, and chimeric mouse models demonstrate that YTHDF2 promotes the accumulation of antibody secreting cells in vivo.
    1. Cancer Biology

    Detection of malignant peripheral nerve sheath tumors in patients with neurofibromatosis using aneuploidy and mutation identification in plasma

    Austin K Mattox et al.
    Detection of aneuploidy and/or mutations in ctDNA may represent a promising approach to detecting patients with MPNST.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Genetic variation of putative myokine signaling is dominated by biological sex and sex hormones

    Leandro M Velez et al.
    Genetic architecture of muscle secreted protein functions are dominated by sex.
    1. Medicine

    Utility of estimated pulse wave velocity for assessing vascular stiffness: comparison of methods

    Stefan Möstl et al.
    Novel blood pressure devices provide an estimated pulse wave velocity, which is no substitute for measured pulse wave velocity and clinicians should be aware that it only reflects trends derived from representative population samples based on age and blood pressure.