Short Reports

A Short Report allows authors to publish the results of a small number of experiments, provided the conclusion is clear and justified, and the findings are novel and judged to be of high importance.

Latest articles

    1. Neuroscience

    Neurexins in serotonergic neurons regulate neuronal survival, serotonin transmission, and complex mouse behaviors

    Amy Cheung, Kotaro Konno ... Kensuke Futai
    Neurexins are presynaptic adhesion molecules in the serotonin system which regulate neuron survival and serotonin neuromodulation through active zone formation and serotonin release.
    1. Neuroscience

    Mechanotransduction events at the physiological site of touch detection

    Luke H Ziolkowski, Elena O Gracheva, Sviatoslav N Bagriantsev
    A novel experimental approach reveals how mechanical force acting on the skin is converted into electrical signaling in sensory neurons to evoke the sensation of touch.
    Short Report Updated
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    1. Genetics and Genomics
    2. Neuroscience

    Monoallelic CRMP1 gene variants cause neurodevelopmental disorder

    Ethiraj Ravindran, Nobuto Arashiki ... Angela M Kaindl
    Genetic finding of pathogenic CRMP1 variants in three unrelated individuals with neurodevelopmental disorder, supported by structural simulation, biochemical and proof-of-principle data highlights the key role of CRMP1 in the development and functioning of the nervous system in humans.
    Short Report Updated
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    1. Neuroscience

    Retinoic acid-gated BDNF synthesis in neuronal dendrites drives presynaptic homeostatic plasticity

    Shruti Thapliyal, Kristin L Arendt ... Lu Chen
    Synaptic silencing-induced homeostatic enhancement of presynaptic glutamate release is mediated by the postsynaptic retinoic acid-dependent brain-derived neurotrophic factor (BDNF) synthesis from dendritically targeted BDNF transcripts, leading to retrograde activation of presynaptic tropomyosin receptor kinase B receptors.
    Short Report Updated
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    1. Cell Biology
    2. Immunology and Inflammation

    Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death

    Jazlyn P Borges, Ragnhild SR Sætra ... Benjamin Ethan Steinberg
    Biochemical and microscopy-based approaches in mouse and human macrophages reveal that glycine cytoprotection acts at the level of the newly identified pan-death protein NINJ1 to inhibit multiple lytic cell death pathways, thereby resolving a long-standing mechanism of glycine cytoprotection.
    Short Report Updated
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    1. Biochemistry and Chemical Biology

    Discovery of a new class of reversible TEA domain transcription factor inhibitors with a novel binding mode

    Lu Hu, Yang Sun ... Xu Wu
    Crystal structural analysis reveals a novel reversible pan-inhibitor of TEA domains with enhanced potency adopts a unique binding mode.
    Short Report Updated
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    1. Computational and Systems Biology
    2. Immunology and Inflammation

    T cell receptor convergence is an indicator of antigen-specific T cell response in cancer immunotherapies

    Mingyao Pan, Bo Li
    Amino acid codon degeneracy indicates antigen-specific selection of the T cell receptors and is predictive of cancer immunotherapy outcomes.
    Short Report Updated
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    1. Structural Biology and Molecular Biophysics

    Structural and functional insights of the human peroxisomal ABC transporter ALDP

    Yutian Jia, Yanming Zhang ... Guanghui Yang
    The Cryo-EM structural and biochemical analysis provides a framework for understanding the working mechanism of ALDP.
    Short Report Updated
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    1. Neuroscience

    Visual experience has opposing influences on the quality of stimulus representation in adult primary visual cortex

    Brian B Jeon, Thomas Fuchs ... Sandra J Kuhlman
    Stimulus representation in primary visual cortex rebounds to its original state following therapeutic sensory deprivation in adults.