A Short Report allows authors to publish the results of a small number of experiments, provided the conclusion is clear and justified, and the findings are novel and judged to be of high importance.
Neurexins are presynaptic adhesion molecules in the serotonin system which regulate neuron survival and serotonin neuromodulation through active zone formation and serotonin release.
Luke H Ziolkowski, Elena O Gracheva, Sviatoslav N Bagriantsev
A novel experimental approach reveals how mechanical force acting on the skin is converted into electrical signaling in sensory neurons to evoke the sensation of touch.
Ethiraj Ravindran, Nobuto Arashiki ... Angela M Kaindl
Genetic finding of pathogenic CRMP1 variants in three unrelated individuals with neurodevelopmental disorder, supported by structural simulation, biochemical and proof-of-principle data highlights the key role of CRMP1 in the development and functioning of the nervous system in humans.
Synaptic silencing-induced homeostatic enhancement of presynaptic glutamate release is mediated by the postsynaptic retinoic acid-dependent brain-derived neurotrophic factor (BDNF) synthesis from dendritically targeted BDNF transcripts, leading to retrograde activation of presynaptic tropomyosin receptor kinase B receptors.
Jazlyn P Borges, Ragnhild SR Sætra ... Benjamin Ethan Steinberg
Biochemical and microscopy-based approaches in mouse and human macrophages reveal that glycine cytoprotection acts at the level of the newly identified pan-death protein NINJ1 to inhibit multiple lytic cell death pathways, thereby resolving a long-standing mechanism of glycine cytoprotection.
