A Short Report allows authors to publish the results of a small number of experiments, provided the conclusion is clear and justified, and the findings are novel and judged to be of high importance.
Rigorous analysis in two knockout mouse lines demonstrates that death receptor 6 is not required for axon degeneration or Schwann cell injury responses following peripheral nerve transection.
Vikash Verma, Patricia Wadsworth, Thomas J Maresca
TIRF imaging of CRISPR-edited human cells shows dynein–dynactin complexes move processively with motility parameters consistent with the presence of multi-dynein assemblies (>one dynein heavy chain dimer per dynactin) in cells.
Mahesh A Vibhute, Corbin Machatzke ... Hannes Mutschler
Structure-guided engineering of a bacterial retron enables intracellular production of a light-up DNA aptamer whose purified DNA retains dye-activated fluorescence, establishing retrons as a scalable route to cellular aptamer synthesis.
Visible light engages a non-visual, bZIP-dependent transcriptional pathway in peripheral tissues that communicates with the nervous system to shape behavioral plasticity and memory, enabling optogenetic-like gene control without photoreceptors.
Genetic perturbation of Afadin in the retina reveals its importance for the precise organization of the retinal layers while leaving neuronal fate and numbers unaffected.
Increased fucosylated IgG and reduced bisecting GlcNAc during HTNV convalescence may promote rapid recovery from hemorrhagic fever with renal syndrome.
Loss of endothelial Slit2 removes the chemo-attractive signal needed for Robo1-positive sympathetic axons to follow coronary vessels, resulting in reduced ventricular innervation.
Caleb CS Calhoun, Mary ES Capps ... Summer B Thyme
Sensitive brain activity mapping and behavioral profiling reveal most microexons are dispensable for early brain development but highlight a small subset with intriguing neural phenotypes for future study.
Jessel Ayra Plasencia, Sara Medina-Suárez ... Félix Machín
The cohesin subunit Scc1 returns and reconstitutes the complex with Smc1–Smc3 in late mitosis upon DNA double-strand breaks, although it does not participate in homologous recombination-driven MAT switching.
