Short Reports

A Short Report allows authors to publish the results of a small number of experiments, provided the conclusion is clear and justified, and the findings are novel and judged to be of high importance.

Latest articles

    1. Structural Biology and Molecular Biophysics

    Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain

    Zhicheng Zuo et al.
    The catalytic activation of the Cas9 HNH domain involves a unique conformational change in the ββα-metal motif that is collectively driven by the interactions with the metal ions and DNA.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    An elusive electron shuttle from a facultative anaerobe

    Emily Mevers et al.
    The identification of ACNQ as an extracellular electron shuttle solves a longstanding problem in bacterial physiology and provides new tool for bioenergy development.
    1. Neuroscience

    Anosognosia for hemiplegia as a tripartite disconnection syndrome

    Valentina Pacella et al.
    High-level disorders, such as motor awareness, are not localised in the brain but emerge from the interaction between brain circuits.
    1. Cancer Biology

    R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma

    Jeroen Overman et al.
    Identification of the R(+)-propranolol enantiomer as an inhibitor of the SOX18 transcription factor activity breaks open potential of drug repurposing in vascular diseases.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Ancient origins of arthropod moulting pathway components

    André Luiz de Oliveira et al.
    Evolutionary reconstruction of the ecdysis pathway shows that its major elements are present in the majority of metazoans, providing evidence that they originated much earlier than currently assumed.
    1. Neuroscience

    Distinct roles of striatal direct and indirect pathways in value-based decision making

    Shinae Kwak, Min Whan Jung
    The direct and indirect pathways of the dorsal striatum play indispensable roles in value-dependent action selection and value learning, respectively.
    1. Structural Biology and Molecular Biophysics

    HDX-MS reveals nucleotide-dependent, anti-correlated opening and closure of SecA and SecY channels of the bacterial translocon

    Zainab Ahdash et al.
    Hydrogen-deuterium exchange mass spectrometry reveals nucleotide-driven conformational regulation of Sec protein-channel to help impose directionality for protein transport through the Sec complex.
    1. Physics of Living Systems

    Swimming eukaryotic microorganisms exhibit a universal speed distribution

    Maciej Lisicki et al.
    Analysis of published studies reveals that flagellates and ciliates separately exhibit log-normal distributions of swimming speeds, and rescaling by the mean speed of each collapses them to a universal relationship.