Short Reports

A Short Report allows authors to publish the results of a small number of experiments, provided the conclusion is clear and justified, and the findings are novel and judged to be of high importance.

Latest articles

    1. Evolutionary Biology
    2. Neuroscience

    Connexins evolved after early chordates lost innexin diversity

    Georg Welzel, Stefan Schuster
    An in silico analysis of gap junction proteins supports the hypothesis that connexins replaced the primordial innexins in chordate gap junctions due to an evolutionary bottleneck.
    1. Cancer Biology
    2. Ecology

    Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe

    Daniel Garcia-Souto et al.
    Genome sequencing analysis dissects the origins and evolution of cancer transmission between clam species in the Seas of Southern Europe.
    1. Computational and Systems Biology
    2. Medicine

    A human-based multi-gene signature enables quantitative drug repurposing for metabolic disease

    James A Timmons et al.
    Optimising the use of transcriptomics enables screening of thousands of compounds and illustrates an approach that yields quantitative pharmacology at the single-gene and pathway level.
    1. Biochemistry and Chemical Biology

    Systematic investigation of the link between enzyme catalysis and cold adaptation

    Catherine Stark et al.
    Increased catalysis has been suggested to be an adaptive trait of enzymes to growth at lower temperature, but systematic analysis suggests that temperature exerts a weak selection pressure on enzyme rate enhancement, with observed variation arising from other evolutionary forces.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Human MAIT cells respond to and suppress HIV-1

    Chansavath Phetsouphanh et al.
    In depth phenotyping from tissues and in vitro activation studies reveal antiviral function of MAIT cells- with particular emphasis on HIV infection.
    1. Medicine

    Aging is associated with increased brain iron through cortex-derived hepcidin expression

    Tatsuya Sato et al.
    Aging is associated with mitochondrial and cytosolic iron accumulation in the brain, which is through increased local expression of hepcidin, and subsequent iron accumulation due to decreased iron export through ferroportin-1.
    1. Ecology
    2. Evolutionary Biology

    Reversal of the adipostat control of torpor during migration in hummingbirds

    Erich R Eberts et al.
    Ruby-throated hummingbirds switch from using torpor to survive nighttime energy emergencies in the breeding season to using it to spare fat stores and gain premigratory mass in the late summer.
    1. Medicine

    Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages

    Marcia A Munoz et al.
    As well as preventing bone loss, bisphosphonate drugs may boost early immune responses in the lung by acting directly on alveolar macrophages that form one of the first lines of defence against infection.
    1. Neuroscience

    Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice

    Julia A Kuhn et al.
    Intrathecal injection of CSF1 induces greater upregulation of spinal microglial genes in male versus female mice, however, Treg depletion enhances microglial activation and restores pain hypersensitivity in the female mice.
    1. Cell Biology

    Golgi membrane protein Erd1 Is essential for recycling a subset of Golgi glycosyltransferases

    Richa Sardana et al.
    Transmembrane protein Erd1 and the cytosolic receptor Vps74 cooperate to mediate early Golgi glycosyltransferase recycling in budding yeast.