A Short Report allows authors to publish the results of a small number of experiments, provided the conclusion is clear and justified, and the findings are novel and judged to be of high importance.
While persistent aggressive states in females are promoted by select cell types with recurrent connections (aIPg, pC1d+e), additional data and models are needed to explain the maintenance of these states.
Huanhuan Joyce Chen, Eric E Gardner ... Harold Varmus
A human pluripotent stem cell-based model demonstrates how TP53/RB1 loss and MYC overexpression drive aggressive, neuroendocrine small cell lung cancer progression and metastasis, enabling investigation of tumor heterogeneity and therapeutic response in a defined genetic context.
The selector gene mirror defines the far posterior wing domain in butterflies, revealing how ancestral axial subdivisions have been evolutionarily reduced in Drosophila.
A high-throughput chemical screen identifies ligands of the Kelch domain of E3 ligase KLHDC2 capable of being modified as proteolysis-targeting chimeras.
Rachel Kaletsky, Rebecca S Moore ... Coleen T Murphy
Deviating from established protocols is the most likely reason why Gainey et al. (2024) could not reproduce earlier results in a Caenorhabditis elegans transgenerational inheritance paradigm, and the earlier findings are also supported by tests with over 30 new genes.
A Sofia F Oliveira, Fiona L Kearns ... Adrian J Mulholland
Equilibrium and nonequilibrium simulations uncover how the fatty acid site in the SARS-CoV-2 spike modulates protein dynamics, revealing its intricate allosteric connections and the impact of glycans on these networks.
RIM-Deep enhances imaging depth in confocal microscopy enabling high-quality visualization of large cleared samples across various fields with minimal cost.
