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A Short Report allows authors to publish the results of a small number of experiments, provided the conclusion is clear and justified, and the findings are novel and judged to be of high importance.
Selective dendritic localization of mRNA in
mushroom body output neurons
Jessica Mitchell et al.
Specific mRNAs localize to the dendrites of
mushroom body output neurons.
Genetics and Genomics
Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study
Chiara Fallerini et al.
In the context of susceptibility to severe COVID-19, the observations of a study provide the basis for a personalized interferon-based therapy in patients with rare TLR7 variants.
Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task
Hongdian Yang et al.
Correlations among LC spiking, membrane potential in S1 cortex, and pupil diameter vary within individual trials of a tactile detection task.
Immunology and Inflammation
Opposing effects of T cell receptor signal strength on CD4 T cells responding to acute versus chronic viral infection
Marco Künzli et al.
T cell receptor signal strength correlates positively with Th1 generation during acute infection but negatively during chronic infection.
Dissecting phenotypic transitions in metastatic disease via photoconversion-based isolation
Yogev Sela et al.
A photoconversion-based isolation technique enables systematic investigation of spatially distinct small metastases (microcolonies) versus large lesions (macrometastases).
α-Synuclein plasma membrane localization correlates with cellular phosphatidylinositol polyphosphate levels
Reeba Susan Jacob et al.
Plasma membrane clusters of the Parkinson's disease protein α-synuclein colocalize with negatively charged phospholipids involved in endocytosis and exocytosis.
Preliminary paleohistological observations of the StW 573 (‘Little Foot’) skull
Amélie Beaudet et al.
Virtual investigation of the 3.67-million-year-old skull of 'Little Foot' using synchrotron radiation reveals histological details of Australopithecus dental and bone tissues.
Control of feeding by Piezo-mediated gut mechanosensation in
Soohong Min et al.
Gut-innervating sensory neurons detect large food volumes and inhibit feeding in
through the mechanically gated ion channel Piezo.
Chromosomes and Gene Expression
Foxc1 establishes enhancer accessibility for craniofacial cartilage differentiation
Pengfei Xu et al.
Foxc1 proteins prepare the genomes of neural crest-derived cells to facilitate their later development into the cartilages that support the embryonic face.
Epidemiology and Global Health
Protective effect of Mediterranean-type glucose-6-phosphate dehydrogenase deficiency against
Ghulam R Awab et al.
The Mediterranean variant of glucose-6-phosphate dehydrogenase deficiency confers a strong gene-dose proportional protective effect against symptomatic
malaria in the Pashtun ethnic group.
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