Systems genetics endeavours to understand how genetic diversity translates into phenotypic diversity. This involves studying how information is transmitted from the genome through RNA and proteins and beyond.
Inspired by early genetic studies in model organisms and humans demonstrating that complex traits – such as height and obesity – are influenced by many loci, systems genetics attempts to explain such variation at the organismal level and, critically, how this is influenced by environmental diversity as well as non-genetic and non-environmental factors.
There is also the challenge of dissecting how biological networks in different organs communicate with each other to determine organismal homeostasis. Systems genetics relies on the comprehensive multi-omics analysis of cells, tissues and organs, and attempts to integrate the information embedded in these networks so that we can better understand complex human diseases and other complex biological problems that remain somewhat intractable.
In recognition of major advances in the area of systems genetics, eLife is pleased to invite submissions for a Special Issue in this important area.
Areas of interest
We are particularly interested in research in the following areas:
- Gene-environment interactions
- Gene-gene interactions
- Interdependence among genes, environment and epigenetics
- Changes over time (development through aging)
- Predictive modelling and experimental validation
- Network biology
- Microbiome-host interactions
- Post-translational modifications
- Protein-protein interaction networks
- Gene regulatory networks
- Personalised/precision medicine
- Bioinformatics tools and analytical methods for integrating multi-omics data
Article types
Submissions of Research Articles, Short Reports, Tools and Resources, and Research Advances are welcomed to the Special Issue. Details about eLife's article types are available here.
Editors for the Systems Genetics Special Issue
David James, University of Sydney, eLife Senior Editor
eLife Senior Editor David James, University of Sydney, will oversee the manuscripts submitted for the Special Issue, alongside:
Guest editors:
David Ashbrook, University of Tennessee Health Science Center
Maroun Bou Sleiman, École polytechnique fédérale de Lausanne
Charles R Farber, University of Virginia School of Medicine
Tune Pers, Novo Nordisk Center
Christine Queitsch, University of Washington
Marcus Seldin, University of California, Irvine
Leah Solberg Woods, Wake Forest School of Medicine
Evan Williams, University of Luxembourg
About eLife
eLife is an interdisciplinary journal committed to improving the way research is reviewed and communicated.
We publish Reviewed Preprints that combine the advantages of preprints with the scrutiny offered by peer review.
Our new publishing process
Papers submitted to eLife will now follow our five step publishing model:
- Submission
- Peer review
- Publication
- Author revision
- Version of Record
In this process we no longer make accept/reject decisions after peer-review. Instead all papers invited for review will be published on our website as a Reviewed Preprint, accompanied by an eLife assessment and public reviews. Find out more about this process.
Peer Review
eLife works to improve the process of peer review so that it more effectively conveys the assessment of expert reviewers to authors, readers and other interested parties.
At the end of the peer review process, authors can submit a response to the assessment and reviews that can be published alongside the Reviewed Preprint.
After the Reviewed Preprint has been published, authors have the choice to either revise and resubmit or to declare the Reviewed Preprint as the final Version of Record.
Read more about our new process and publishing at eLife
Submit to the Special Issue
eLife is an interdisciplinary journal where active researchers handle all editorial decisions. We don’t artificially limit the number of articles we publish or have a set acceptance rate.
Rather, we rely on the judgement of the working researchers who serve as our editors to select papers for peer review and publication.
Peer review
Our goal is to make peer review faster (by reducing rounds of revisions), fairer and more open.
Submit to the Special Issue
Authors interested in being part of this Special Issue can submit their manuscripts via eLife’s submission system.
All authors should include a cover letter in their submission, highlighting that the paper is for consideration in this Special Issue and suggesting editors from the list above.
Papers will be published online when they’re ready.
Following feedback from our community, we have extended the deadline for submission to this Special Issue until March 31, 2023.
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