Supplementary material

Marlon Cerf

Eduardo Franco

eLife Assessment
The study presents valuable findings on Mendelian randomization-phenome-wide association, with BMI associated with health outcomes, and there is a focus on sex differences. The phenotype and genotype data are convincing. The work will be of interest to researchers and clinicians in epidemiology, public health and medicine.

anonymous

Reviewer #2 (Public review):
Summary:
In this present Mendelian randomization-phenome-wide association study, the authors found BMI to be positively associated with many health-related conditions, such as heart disease, heart failure, and hypertensive heart disease. They also found sex differences in some traits, such as cancer, psychological disorders, and ApoB.
Strengths:
The use of the UK-biobank study with detailed phenotype and genotype information.
Comments on revisions:
I believe the authors have presented convincing arguments for the novelty and interpretation of their study. I have no additional comments.

A Sex-specific Mendelian Randomization-Phenome-Wide Association Study of Body Mass Index

Figures and data

Sex differences of body mass index on phenotypes in men (n: 167,020) and women (n: 194,174)

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