eLife publishes research spanning malaria, tuberculosis, trypanosomiasis, HIV/AIDS and drug discovery. Decisions are made by journal editors who are active researchers in epidemiology and global health.
A common chromosome inversion in African malaria mosquito (Anopheles gambiae) is associated with differences in malaria infection, adult resting behavior and ecology, and may aid the most efficient vectors to evade malaria control.
The sickle cell trait strongly protects against not only retinopathy-positive cerebral malaria but also retinopathy-negative cerebral malaria, providing evidence that malarial parasites also contribute to retinopathy-negative cerebral malaria and are not innocent bystanders.
A field study coupled with a molecular analysis demonstrates that using hematophagous flies as 'flying syringes' could be used to investigate blood-borne pathogen diversity in wild vertebrates and act as an early detection tool of zoonotic pathogens.
Ending the TB epidemic requires scaling up access to new TB tools so that they can benefit the patients in low- and middle-income countries that need them the most.
In silico modelling of all available data shows that a twenty-day ascending-dose primaquine regimen could be safe to administer to G6PD deficient patients for the radical cure of vivax malaria.
Stochastic models able to reproduce both incidence and seroprevalence data for Zika outbreaks in the Pacific Islands estimate that the basic reproduction number (R0) is between 1.5 and 4.1.
Increasing levels of glucose-6-phosphate dehydrogenase deficiency are associated with decreasing risk of cerebral malaria, but with increased risk of severe malarial anaemia.
The global suitability for avian flu H5N1 in poultry is predicted and spatially cross-validated, highlighting areas where the disease can spread in the absence of prevention and control, and represent a public health threat.
We identify key strengths and limitations in use of viral genotyping and phenotyping to estimate pandemic risk from influenza A viruses, focusing on 3 traits, hemagglutinin binding specificity, hemagglutinin pH of activation, and polymerase complex efficiency.
A rigorous and transparent evaluation of mesenchymal stem cell therapy for sepsis suggests it may be efficacious, although the strength of these findings is tempered by threats to validity in the studies that were included.
