Epidemiology and Global Health

eLife publishes research spanning malaria, tuberculosis, trypanosomiasis, HIV/AIDS and drug discovery. Decisions are made by journal editors who are active researchers in epidemiology and global health.

Latest articles

    1. Epidemiology and Global Health

    Evidence from a natural experiment that malaria parasitemia is pathogenic in retinopathy-negative cerebral malaria

    Dylan S Small et al
    The sickle cell trait strongly protects against not only retinopathy-positive cerebral malaria but also retinopathy-negative cerebral malaria, providing evidence that malarial parasites also contribute to retinopathy-negative cerebral malaria and are not innocent bystanders.
    Short Report
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    1. Ecology
    2. Epidemiology and Global Health

    Tracking zoonotic pathogens using blood-sucking flies as 'flying syringes'

    Paul-Yannick Bitome-Essono et al
    A field study coupled with a molecular analysis demonstrates that using hematophagous flies as 'flying syringes' could be used to investigate blood-borne pathogen diversity in wild vertebrates and act as an early detection tool of zoonotic pathogens.
    Tools and Resources Updated
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    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Point of View: Tuberculosis innovations mean little if they cannot save lives

    Madhukar Pai, Jennifer Furin
    Ending the TB epidemic requires scaling up access to new TB tools so that they can benefit the patients in low- and middle-income countries that need them the most.
    Feature Article
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    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    Modelling primaquine-induced haemolysis in G6PD deficiency

    James Watson et al
    In silico modelling of all available data shows that a twenty-day ascending-dose primaquine regimen could be safe to administer to G6PD deficient patients for the radical cure of vivax malaria.
    Research Article Updated
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    1. Epidemiology and Global Health

    Structure in the variability of the basic reproductive number (R0) for Zika epidemics in the Pacific islands

    Clara Champagne et al
    Stochastic models able to reproduce both incidence and seroprevalence data for Zika outbreaks in the Pacific Islands estimate that the basic reproduction number (R0) is between 1.5 and 4.1.
    Research Article Updated
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    1. Epidemiology and Global Health
    2. Genomics and Evolutionary Biology

    Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia

    Geraldine M Clarke et al
    Increasing levels of glucose-6-phosphate dehydrogenase deficiency are associated with decreasing risk of cerebral malaria, but with increased risk of severe malarial anaemia.
    Research Article
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    1. Epidemiology and Global Health

    Global mapping of highly pathogenic avian influenza H5N1 and H5Nx clade 2.3.4.4 viruses with spatial cross-validation

    Madhur S Dhingra et al
    The global suitability for avian flu H5N1 in poultry is predicted and spatially cross-validated, highlighting areas where the disease can spread in the absence of prevention and control, and represent a public health threat.
    Research Article Updated
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    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Science Forum: Viral factors in influenza pandemic risk assessment

    Marc Lipsitch et al
    We identify key strengths and limitations in use of viral genotyping and phenotyping to estimate pandemic risk from influenza A viruses, focusing on 3 traits, hemagglutinin binding specificity, hemagglutinin pH of activation, and polymerase complex efficiency.
    Feature Article Updated
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    1. Epidemiology and Global Health
    2. Human Biology and Medicine

    Evaluating mesenchymal stem cell therapy for sepsis with preclinical meta-analyses prior to initiating a first-in-human trial

    Manoj M Lalu et al
    A rigorous and transparent evaluation of mesenchymal stem cell therapy for sepsis suggests it may be efficacious, although the strength of these findings is tempered by threats to validity in the studies that were included.
    Research Article Updated
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    1. Epidemiology and Global Health
    2. Genomics and Evolutionary Biology

    A transmission-virulence evolutionary trade-off explains attenuation of HIV-1 in Uganda

    François Blanquart et al
    Analysis of epidemiological data reveals that viral loads in newly HIV-1 infected individuals in Uganda have declined for two decades, and evolutionary modelling shows that attenuation of the virus explains this decline.
    Research Article Updated
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