Epidemiology and Global Health

Latest articles

1. 1. Epidemiology and Global Health

   High infectiousness immediately before COVID-19 symptom onset highlights the importance of continued contact tracing

   William S Hart et al.

   Fitting a mechanistic model to data from SARS-CoV-2 source-recipient pairs generates improved estimates of changes in infectiousness during infection, indicating substantial transmission shortly before symptom onset.
2. 1. Epidemiology and Global Health

   Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection

   Allison Koenecke et al.

   Patients exposed to ⍺1-AR antagonists have reduced risks of mechanical ventilation and death in lower respiratory tract infection-related illnesses, highlighting the need for prospective trials assessing ⍺1-AR antagonists' effectiveness in COVID-19.
3. 1. Epidemiology and Global Health

   Alcohol consumption in the general population is associated with structural changes in multiple organ systems

   Evangelos Evangelou et al.

   The results imply that there is not a safe threshold below which there are no toxic effects of alcohol.
4. 1. Epidemiology and Global Health

   FnCas9 based CRISPR diagnostic for rapid and accurate detection of major SARS-CoV2 variants on a paper strip

   Manoj Kumar et al.
5. 1. Epidemiology and Global Health

   Asymptomatic Bordetella pertussis infections in a longitudinal cohort of young African infants and their mothers

   Christopher J Gill et al.

   Longitudinal qPCR-based pertussis surveillance of a low-resource African cohort reveals frequent asymptomatic pertussis infections in both young infants and mothers and suggests possible early warning signals for epidemic outbreaks.
6. 1. Epidemiology and Global Health

   Convalescent plasma use in the United States was inversely correlated with COVID-19 mortality

   Arturo Casadevall et al.
7. 1. Epidemiology and Global Health
   2. Medicine

   Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population

   Heli Julkunen et al.

   Metabolic biomarkers measured from single blood test can identify apparently healthy people at high susceptibility for developing severe pneumonia, and may also be useful for preventive COVID-19 screening.
8. 1. Epidemiology and Global Health
   2. Medicine

   An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk

   Torsten Dahlén et al.

   The relationship between blood groups and disease is detangled, without preconceived ideas, using population-wide data, with millions of participants and lifetime follow-up, identifying not only previously known relationships but also new insights.
9. 1. Epidemiology and Global Health
   2. Microbiology and Infectious Disease

   Systematic screening of viral and human genetic variation identifies antiretroviral resistance and immune escape link

   Huyen Nguyen et al.

   The presence of certain HLA alleles drives the emergence or maintenance of otherwise deleterious drug-resistant mutations in patients living with HIV, even when the patient is antiretroviral treatment naïve.
10. 1. Epidemiology and Global Health
    2. Medicine

    Mapping the endemicity and seasonality of clinical malaria for intervention targeting in Haiti using routine case data

    Ewan Cameron et al.

    A demonstration of the power of routine case data and statistical modelling to guide the allocation of anti-malarial interventions in a resource-constrained setting.