Figures and data

Flowchart of data selection for cross-sectional analyses (left) and longitudinal analyses (right).


Sample characteristics.

Unadjusted and adjusted cross-sectional parameter estimates of self-reported total physical activity on brain structure and cognition.

Unadjusted and adjusted cross-sectional parameter estimates of accelerometer-derived average MET/day on brain structure.

Unadjusted and adjusted cross-sectional parameter estimates of self-reported moderate to vigorous physical activity (MVPA) on brain structure and cognition.

Graphical representation of two path analyses of the relationship between physical activity and A) cognitive function and B) BrainAGE (BA) at baseline, and physical capacity and cognitive function or BA at follow-up.
Age at baseline was used as covariate at both time points. No statistically significant effects of either PA at baseline on cognition at follow-up, nor of cognition at baseline on follow-up physical capacity can be observed. Model B shows a negative effect of structural brain ageing on physical capacity at follow-up, but no effect of PA at baseline on brain structural ageing pattern at follow-up. (Note. * p < .05; **p < .01; *** p < .001)

Directed acyclic graph for the effect of physical activity on hippocampal volume.

Unadjusted and adjusted cross-sectional parameter estimates of self-reported total and MVPA as well as objectively measured physical activity on left hippocampal volume.

Unadjusted and adjusted cross-sectional parameter estimates of self-reported total physical activity on brain structure and cognition of adults aged 30-60 years.

Unadjusted and adjusted cross-sectional parameter estimates of self-reported moderate to vigorous physical activity on brain structure and cognition in a sample aged 30-60 years.

Unadjusted and adjusted cross-sectional parameter estimates of accelerometer-derived average MET/day on brain structure of adults aged 30-60 years (n = 70).

Unadjusted and adjusted cross-sectional parameter estimates of accelerometer-derived average MET/day on brain structure of older adults (age >60 years, n = 151).

Unadjusted and adjusted cross-sectional parameter estimates of self-reported total physical activity on brain structure and cognition of men.

Unadjusted and adjusted cross-sectional parameter estimates of self-reported total physical activity on brain structure and cognition of women.

Unadjusted and adjusted cross-sectional parameter estimates of accelerometer-derived average MET/day on brain structure of men.

Unadjusted and adjusted cross-sectional parameter estimates of accelerometer-derived average MET/day on brain structure of women.

Unadjusted and adjusted cross-sectional parameter estimates of self-reported moderate to vigorous physical activity on brain structure and cognition in men.
