Neuroscience

Neuroscience

eLife reviews research including brain function, neuronal circuits, synapses, sensory processing and motor pattern generation. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Neuroscience

    Complementary stable and dynamic prelimbic ensembles encode learned threat value underlying generalization and discrimination

    Marc E Normandin, Pedro M Ogallar ... Isabel A Muzzio
    Stable and dynamic prelimbic neurons preserve threat-generalization gradients despite ensemble turnover, supporting enduring representations of stimulus significance rather than freezing.
    1. Neuroscience

    A mechanistic theory of planning in prefrontal cortex

    Kristopher T Jensen, Peter T Doohan ... Timothy E Behrens
    Recently discovered sequence representations in prefrontal cortex can be combined with the ubiquitous principle of neural attractor dynamics to support planning in complex environments.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    An integrated human forebrain organoid reveals microglia-mediated CD8+ T cell recruitment and neuroimmune dysfunction in Alzheimer’s disease pathology

    Yilin Feng, Feifei Yu ... Shaohua Ma
    Human forebrain organoids reveal that amyloid-driven microglia recruit killer T cells via CCL5, forming a self-amplifying neuroinflammatory loop targetable by CCR5 or CXCR3 blockade.
    1. Neuroscience

    Multiplexed CRISPRi reveals a transcriptional switch between KLF activators and repressors in the maturing neocortex

    Ryan W Kirk, Liwei Sun ... Sacha B Nelson
    In mammalian neocortex, opposing Krüppel-like factor (KLF) transcription factors first activate and then repress a genetic program related to axon outgrowth, potentially contributing to loss of cortical axon outgrowth in the adult.
    1. Neuroscience

    A reinforcement learning framework for goal-directed stimulation of engineered neuronal networks

    Benedikt Maurer, Vaiva Vasiliauskaitė ... Stephan J Ihle
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Theta phase and theta-gamma coupling organise the spoken language network

    Haya Akkad, Daniel Bush ... Jenny Crinion
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Developmental Biology
    2. Neuroscience

    Glia regulate local retinoic acid levels to specify neuronal specialisation for high-acuity vision

    Manuela Lahne, Roxana Lungu ... Ryan B MacDonald
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Identifying Novel Estrogenic Mitochondrial Targets in Hypothalamic Proopiomelanocortin Neurons by Chemoproteomics

    Jian Qiu, Martha A Bosch ... Martin J Kelly
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Neuroscience

    Real-Time Embodied Experience Shapes High-Level Reasoning Under Altered Gravity

    Hélène Grandchamp des Raux, Tommaso Ghilardi ... Ori Ossmy
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    • Incomplete
    1. Neuroscience

    Single neurons detect spatiotemporal activity transitions through STP and EI imbalance

    Aditya Asopa, Upinder Singh Bhalla
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
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Highlights

    1. Neuroscience
    Image credit: tama66 (CC0)

    How monkeys carve up the visual world

    Binxu Wang
    1. Neuroscience
    Image credit: geralt (CC0)

    Understanding the cellular architecture of Huntington’s disease

    Dorian Pustina
    1. Neuroscience
    Merrilee Schultz (CC0 via unsplash)

    Stronger memories through smarter stimulation

    Justin Riddle

Senior editors

  1. Merritt Maduke
    Stanford University School of Medicine, United States
  2. Kenton J Swartz
    National Institute of Neurological Disorders and Stroke, NIH, United States
  3. Ma-Li Wong
    State University of New York Upstate Medical University, United States
  4. See more editors