Neuroscience

Neuroscience

eLife reviews research including brain function, neuronal circuits, synapses, sensory processing and motor pattern generation. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Neuroscience

    Untangling stability and gain modulation in cortical circuits with multiple interneuron classes

    Hannah Bos, Christoph Miehl ... Brent Doiron
    In recurrently connected cortical networks with different inhibitory neuron subtypes, circuit modulations can increase neuronal gain without compromising network stability.
    1. Neuroscience

    Neural substrates of cold nociception in Drosophila larva

    Atit A Patel, Albert Cardona, Daniel N Cox
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    A multiplex of connectome trajectories enables several connectivity patterns in parallel

    Parham Mostame, Jonathan Wirsich ... Sepideh Sadaghiani
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Immunology and Inflammation
    2. Neuroscience

    Microglia aging in the hippocampus advances through intermediate states that drive activation and cognitive decline

    Jeremy M Shea, Saul A Villeda
    During aging, microglia progress through intermediate cellular states, including stress response and translation upregulation states, that modulate subsequent activation and impact cognitive decline.
    1. Neuroscience

    A toolbox for ablating excitatory and inhibitory synapses

    Aida Bareghamyan, Changfeng Deng ... Don B Arnold
    Novel genetically encoded tools PFE3, paGFE3, and chGFE3 can be used to reversibly ablate excitatory synapses constitutively, and inhibitory synapses in a light- or chemically dependent manner.
    1. Neuroscience

    Leveraging place field repetition to understand positional versus nonpositional inputs to hippocampal field CA1

    William Hockeimer, Ruo-Yah Lai ... James J Knierim
    Place cells that show repeating place fields in geometrically similar locations of an environment modulate their firing rates differently in each field based on movement direction.
    1. Neuroscience

    Olfactory ensheathing cells from adult female rats are hybrid glia that promote neural repair

    Patricia E Phelps, Sung Min Ha ... Xia Yang
    To better understand how olfactory ensheathing cells modify spinal cord injury sites, single-cell RNA-sequencing was used to identify five OEC subtypes, progenitors, and novel genes associated with axonal outgrowth.
    1. Neuroscience

    Viral-mediated Oct4 overexpression and inhibition of Notch signaling synergistically induce neurogenic competence in mammalian Müller glia

    Nguyet Le, Sherine Awad ... Seth Blackshaw
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Neuroscience

    Rhythmic circuit function is more robust to changes in synaptic than intrinsic conductances

    Zachary Fournier, Leandro M Alonso, Eve Marder
    Modifications of the intrinsic currents in neuronal circuits are more likely to result in loss of function than changes in synaptic strength.
    1. Neuroscience

    Cholecystokinin modulates age-dependent Thalamocortical Neuroplasticity

    Xiao Li, Jingyu Feng ... Jufang He
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing

Highlights

    1. Neuroscience

    Neuropeptides and pain

    Weihua Cai, Arkady Khoutorsky
    1. Genetics and Genomics
    2. Neuroscience

    Targeting single neurons

    Brandon L Holder, Stephane Dissel

Senior editors

  1. Christian Büchel
    University Medical Center Hamburg-Eppendorf, Germany
  2. Merritt Maduke
    Stanford University School of Medicine, United States
  3. Tamar Makin
    University College London, United Kingdom
  4. See more editors