Neuroscience

Neuroscience

eLife publishes research including brain function, neuronal circuits, synapses, sensory processing and motor pattern generation. Decisions are made by journal editors who are active researchers in neuroscience.
Illustration by Davide Bonazzi

Latest articles

    1. Neuroscience

    Environmental stimuli shape microglial plasticity in glioma

    Stefano Garofalo et al.
    The microenvironment of brain tumors can be modulated by in vivo conditions that change the brain levels of BDNF and IL-15, with effects on innate immune cell activation.
    1. Neuroscience

    A postsynaptic PI3K-cII dependent signaling controller for presynaptic homeostatic plasticity

    Anna G Hauswirth et al.
    A screen encompassing all kinases and phosphatases reveals that PI3K-cII, PI3K-cIII and Rab11-dependent recycling endosomes comprise a novel, postsynaptic 'signaling controller' that is part of an integrated, trans-synaptic signaling system necessary for presynaptic homeostatic plasticity.
    1. Neuroscience

    Output variability across animals and levels in a motor system

    Angela Wenning et al.
    Population output variability in a motor control system varies across levels (CPG, motor neurons, muscles) and can be ascribed to life history differences among animals and in some cases to differences between bilaterally homologous elements.
    1. Neuroscience

    Astrocytic modulation of excitatory synaptic signaling in a mouse model of Rett syndrome

    Benjamin Rakela et al.
    Astrocytes impact neuronal signaling in brain dependent on status of the transcriptional repressor, Methyl CpG Binding Protein 2.
    1. Neuroscience

    Interactions between stimulus and response types are more strongly represented in the entorhinal cortex than in its upstream regions in rats

    Eun-Hye Park et al.
    Goal-directed interaction with objects and spatial navigation are subserved by the perirhinal-lateral entorhinal networks and the postrhinal-medial entorhinal networks, respectively, with action-based functional differentiation more strongly represented in the entorhinal cortex than its upstream.
    1. Cell Biology
    2. Neuroscience

    Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery

    Ting-Ya Chang et al.
    Hippocampal neurons undergo bi-stable behavior as neurites emerge, and the dominance of either state is determined by environmental mechanical properties and paxillin-associated cellular endocytic activities.

Highlights

    1. Neuroscience

    Making connections in the brain

    Alex TL Leong, Ed X Wu

Senior editors

  1. Richard Aldrich
    Richard Aldrich
    Senior Editor
  2. Timothy Behrens
    Timothy Behrens
    Senior Editor
  3. Catherine Dulac
    Catherine Dulac
    Senior Editor
  4. See more editors