Neuroscience

Latest articles

1. 1. Neuroscience

   Distinct neural representations of perceptual and numerical absence in the human brain

   Benjy Barnett, Stephen M Fleming
2. 1. Neuroscience

   Enhancer-AAVs allow genetic access to oligodendrocytes and diverse populations of astrocytes across species

   John K Mich, Smrithi Sunil ... Boaz P Levi
3. 1. Neuroscience

   Motor unit mechanisms of speed control in mouse locomotion

   Kyle Thomas, Rhuna Gibbs ... Samuel J Sober

   Recording the spiking activity of muscle fibers at high resolution in awake, behaving mice, reveals that locomotor speed is driven by highly variable subsets of motor units.
4. 1. Computational and Systems Biology
   2. Neuroscience

   Olfactory combinatorial coding supports risk–reward decision-making in Caenorhabditis elegans

   Md Zubayer Hossain Saad, William G Ryan ... Bruce A Bamber

   An odorant is encoded in the periphery as independent inputs of attractive and repulsive valence, which are then integrated and balanced to drive overall chemotactic behavior.
5. 1. Structural Biology and Molecular Biophysics
   2. Neuroscience

   Synaptic Organization of Surface AMPARs Changes by Brain Region and Tauopathy

   Rohit M Vaidya, Jiahao Zhang ... Paul R Selvin
6. 1. Neuroscience

   Complementary stable and dynamic prelimbic ensembles encode learned threat value underlying generalization and discrimination

   Marc E Normandin, Pedro M Ogallar ... Isabel A Muzzio

   Stable and dynamic prelimbic neurons preserve threat-generalization gradients despite ensemble turnover, supporting enduring representations of stimulus significance rather than freezing.
7. 1. Neuroscience

   A mechanistic theory of planning in prefrontal cortex

   Kristopher T Jensen, Peter T Doohan ... Timothy E Behrens

   Recently discovered sequence representations in prefrontal cortex can be combined with the ubiquitous principle of neural attractor dynamics to support planning in complex environments.
8. 1. Neuroscience

   Strong mnemonic prediction errors increase cognitive control, attention, and arousal

   Alice M Xue, Jenna Jokhani ... Anthony D Wagner

   Violations of strong memory-based predictions trigger a cascade of changes in cognitive control, attention, and arousal, with differential impacts on the encoding of unexpected information into memory.
9. 1. Neuroscience
   2. Stem Cells and Regenerative Medicine

   An integrated human forebrain organoid reveals microglia-mediated CD8⁺ T cell recruitment and neuroimmune dysfunction in Alzheimer’s disease pathology

   Yilin Feng, Feifei Yu ... Shaohua Ma

   Human forebrain organoids reveal that amyloid-driven microglia recruit killer T cells via CCL5, forming a self-amplifying neuroinflammatory loop targetable by CCR5 or CXCR3 blockade.
10. 1. Neuroscience

    Multiplexed CRISPRi reveals a transcriptional switch between KLF activators and repressors in the maturing neocortex

    Ryan W Kirk, Liwei Sun ... Sacha B Nelson

    In mammalian neocortex, opposing Krüppel-like factor (KLF) transcription factors first activate and then repress a genetic program related to axon outgrowth, potentially contributing to loss of cortical axon outgrowth in the adult.