Neuroscience

Neuroscience

eLife publishes research including brain function, neuronal circuits, synapses, sensory processing and motor pattern generation. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Neuroscience

    A critical re-evaluation of fMRI signatures of motor sequence learning

    Eva Berlot et al.
    A systematic assessment of previously proposed fMRI metrics of motor sequence learning reveals widespread activity reductions and subtle multivariate pattern changes outside of primary motor cortex.
    1. Developmental Biology
    2. Neuroscience

    Transverse sinus injections drive robust whole-brain expression of transgenes

    Ali S Hamodi et al.
    A new viral injection method targets the transverse sinuses to achieve robust whole-brain delivery of single or multiple genes in multiple mammalian species early in development.
    1. Neuroscience

    Dopaminergic modulation of the exploration/exploitation trade-off in human decision-making

    Karima Chakroun et al.
    Dopamine attenuates exploration during decision-making via a reduction of neural tracking of uncertainty.
    1. Neuroscience

    Hyperalignment: Modeling shared information encoded in idiosyncratic cortical topographies

    James V Haxby et al.
    Hyperalignment provides a conceptual framework for cortical architecture that captures how shared information is encoded in idiosyncratic cortical topographies that preserve vector geometry for population response and connectivity patterns.
    1. Neuroscience

    Temperature compensation in a small rhythmic circuit

    Leandro M Alonso, Eve Marder
    1. Neuroscience

    MeCP2 in cholinergic interneurons of nucleus accumbens regulates fear learning

    Ying Zhang et al.
    Robust fear learning deficits and decreased tonic activity of NAc cholinergic interneurons caused by depletion of MeCP2 could be attributed to an elevation in α2-containing GABAA receptors.
    1. Neuroscience

    Axon-dependent expression of YAP/TAZ mediates Schwann cell remyelination but not proliferation after nerve injury

    Matthew Grove et al.
    YAP and TAZ, potent concoproteins and therapeutic targets in cancer therapy, are essential for Schwann cells to support peripheral nerve regeneration.
    1. Neuroscience

    Hippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adults

    Alexandra N Trelle et al.
    The strength of pattern completion during memory retrieval, indexed by hippocampal activity and cortical reinstatement, explains within- and across-individual variability in episodic memory in older adults.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Disease-associated mutations in the human TRPM3 render the channel overactive via two distinct mechanisms

    Siyuan Zhao et al.
    Disease-associated mutants of the TRPM3 ion channel are overactive, and they are inhibited by the antiepileptic medication primidone, offering a potential therapeutic intervention to treat this channelopathy.

Highlights

    1. Neuroscience

    Motor Performance: Acetylcholine in action

    Erin M Wall, Sarah C Woolley
    1. Genetics and Genomics
    2. Neuroscience

    Why the young sleep longer

    Budhaditya Chowdhury, Orie T Shafer

Senior editors

  1. Jonathan A Cooper
    Jonathan A Cooper
    Fred Hutchinson Cancer Research Center, United States
  2. John Huguenard
    Stanford University School of Medicine, United States
  3. Richard Ivry
    University of California, Berkeley, United States
  4. See more editors