Comparison of Las1-Grc3, Ire1 and RNase L.
Comparison of structural assembly, activation and substrate recognition mechanisms of Las1-Grc3, Ire1 and RNase L. Two HEPN domains in Las1, Ire1 and RNase L are colored in pink and violet, respectively. Two PNK domains in Grc3, two Kinase domains in Ire1, and two Preudo-Kinase domains in RNase L, are colored in cyan and greencyan, respectively. The catalytic site is highlighted with a yellow box.